5A2S | Genus

Total Genus 137

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	137
sequence length	380
structure length	380
Chain Sequence	TTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPANRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQ

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Hydrolase
source organism	Homo sapiens
publication title	Potent, Selective, and Cns-Penetrant Tetrasubstituted Cyclopropane Class Iia Histone Deacetylase (Hdac) Inhibitors. pubmed doi rcsb
molecule keywords	HISTONE DEACETYLASE 4
total genus	137
structure length	380
sequence length	380
chains with identical sequence	B
ec nomenclature	ec 3.5.1.98: Histone deacetylase.
pdb deposition date	2015-05-22

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00850	Hist_deacetyl	Histone deacetylase domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.800.20	Alpha Beta	3-Layer(aba) Sandwich	Arginase; Chain A	Histone deacetylase domain	5a2sA00

5G0HA 5G1CA 5EF7A 5EEMA 5JI5A 5THVA 5EF8A 1T69A 3SFHA 3Q9EA 3EWFA 4QA3A 5D1CA 4RN0A 4CBYA 1C3RA 5ICNB 4BZ6A 5EFHA 1ZZ1A 4RN2A 2VQJA 3C10A 5EENA 4ZUNA 5BWZA 5G0XA 4QA2A 4BZ9A 4ZUPA 5IWGA 5G10A 2VQOA 5DC6A 4CQFA 5EEIA 3EW8A 5DC5A 3SFFA 1T64A 2VQMA 5EFNA 5G0JA 3C0YA 5G13A 3MZ3A 4ZUMA 5D1BA 3F07A 1W22A 3F0RA 5THSA 4BZ7A 3F06A 1ZZ3A 5EFBD 5EFJD 2VQWG 5G11A 4BZ5A 4BZ8A 2VCGA 2V5WA 3ZNRA 5G1BA 5IX0A 5EFGA 4LXZA 5G0GA 5G0IA 5EEKA 5G17A 5LI3A 3C0ZA 3RQDA 3MENA 3Q9CA 5G3WA 1C3PA 4BKXB 5FUEA 5G1AA 5EFKB 2VQQA 3EZTA 3MZ6A 4ZUQA 4A69A 5G12A 1T67A 3MAXA 3MZ7A 5D1DA 4QA5A 5G0YA 2GH6A 1VKGA 4QA6A 4QA0A 1ZZ0A 1C3SA 4RN1A 5EEFA 3ZNSA 5THUA 5A2SA 5DC8A 4ZURA 3Q9FA 2V5XA 4QA1A 3MZ4A 5FCWA 4LY1A 5DC7A 4QA7A 4CBTA 3Q9BA 5THTA 4QA4A 3EZPA 4ZUOA 2VQVA
chains in the Genus database with same CATH superfamily

5G0HA 4HZEA 1WVBA 4MYKA 3MFWA 5G1CA 5EF7A 1T4SA 4RHQA 5EEMA 5JI5A 5THVA 1D3VA 1T69A 5EF8A 3SFHA 3Q9EA 3THJA 2PHAA 3EWFA 5RLAA 4QA3A 1WVAA 4RLAA 1P8PA 2CEVA 5D1CA 4RN0A 2RLAA 4CBYA 1C3RA 5ICNB 5CEVA 4BZ6A 4DZ4A 4HWWA 1HQFA 3DJ8A 5EFHA 1CEVA 4IU0A 1P8MA 4CEVA 1ZZ1A 3PZLA 2VQJA 1WOHA 3C10A 4FCKA 4RN2A 4ITYA 5EENA 4ZUNA 5G0XA 4Q3QA 4Q40A 5BWZA 4QA2A 4BZ9A 4ZUPA 5IWGA 3KV2A 5G10A 1T4TA 3TF3A 2VQOA 5DC6A 4CQFA 5EEIA 3SJTA 1GQ6A 4Q3TA 1TBHA 2PLLA 1RLAA 3EW8A 5DC5A 4RHIA 3SFFA 1P8OA 3THHA 1T64A 4ZUOA 2VQMA 5EFNA 5G0JA 3C0YA 5G13A 3MZ3A 4ZUMA 1PQ3A 3F80A 5D1BA 3F07A 1W22A 3F0RA 4IXUA 4Q3PA 3E6VA 5THSA 4IE2A 4BZ7A 3F06A 1ZZ3A 2ZAVA 3LP4A 5EFBD 5EFJD 2VQWG 5G11A 1HQGA 4IE3A 3RLAA 4RHJA 4BZ8A 4RHLA 4BZ5A 4Q3UA 1T5GA 2VCGA 4Q42A 2V5WA 2AEBA 2EF5A 1ZPEA 3ZNRA 5G1BA 3TH7A 4MYNA 5IX0A 5EFGA 1WOGA 4IU1A 3M1RA 1P8RA 1HQHA 4IE1A 4LXZA 1P8SA 1T5FA 3CEVA 4IU4A 4MYLA 3GN0A 5EEKA 5G0GA 5G17A 5G0IA 3C0ZA 5HJAA 3SKKA 3RQDA 3MENA 1TA1A 2PHOA 3Q9CA 5G3WA 4Q3RA 1C3PA 1TBJA 4BKXB 2EIVA 3SL0A 3NIQA 5FUEA 1GQ7A 5G1AA 5EFKB 3E8QA 2VQQA 3EZTA 3MZ6A 4ZUQA 4A69A 5G12A 4I06A 1T67A 3MAXA 3GMZA 1HQXA 4MYFA 3E6KA 3MZ7A 1P8NA 5LI3A 1ZPGA 1WOIA 5D1DA 4G3HA 4QA5A 4Q3VA 5G0YA 2GH6A 1VKGA 4QA6A 4GSZA 4QA0A 1TBLA 1ZZ0A 4Q41A 1R1OA 1C3SA 4Q3RC 4RN1A 3MJLA 3E9BA 3LHLA 5EEFA 2A0MA 3ZNSA 4MXRA 5THUA 4GWCA 5A2SA 5DC8A 3THEA 2EF4A 1XFKA 4ZURA 3SL1A 4IXVA 3MMRA 3NIOA 3LP7A 3Q9FA 4FCIA 4GSMA 2V5XA 3MFVA 4HXQA 5HJ9A 4RHKA 4QA1A 4GSVA 1T4RA 3MZ4A 1HQ5A 5FCWA 4LY1A 3E8ZA 4RHMA 3NIPA 5DC7A 4GWDA 1T4PA 4QA7A 4CBTA 3Q9BA 1P8QA 5THTA 4Q3SA 4QA4A 3EZPA 4IU5A 2VQVA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 5G0H A;  5G1C A;  5EF7 A;  5EEM A;  5JI5 A;  5THV A;  5EF8 A;  1T69 A;  3SFH A;  3Q9E A;  3EWF A;  4QA3 A;  5D1C A;  4RN0 A;  4CBY A;  1C3R A;  5ICN B;  4BZ6 A;  5EFH A;  1ZZ1 A;  4RN2 A;  2VQJ A;  3C10 A;  5EEN A;  4ZUN A;  5BWZ A;  5G0X A;  4QA2 A;  4BZ9 A;  4ZUP A;  5IWG A;  5G10 A;  2VQO A;  5DC6 A;  4CQF A;  5EEI A;  3EW8 A;  5DC5 A;  3SFF A;  1T64 A;  2VQM A;  5EFN A;  5G0J A;  3C0Y A;  5G13 A;  3MZ3 A;  4ZUM A;  5D1B A;  3F07 A;  1W22 A;  3F0R A;  5THS A;  4BZ7 A;  3F06 A;  1ZZ3 A;  5EFB D;  5EFJ D;  2VQW G;  5G11 A;  4BZ5 A;  4BZ8 A;  2VCG A;  2V5W A;  3ZNR A;  5G1B A;  5IX0 A;  5EFG A;  4LXZ A;  5G0G A;  5G0I A;  5EEK A;  5G17 A;  5LI3 A;  3C0Z A;  3RQD A;  3MEN A;  3Q9C A;  5G3W A;  1C3P A;  4BKX B;  5FUE A;  5G1A A;  5EFK B;  2VQQ A;  3EZT A;  3MZ6 A;  4ZUQ A;  4A69 A;  5G12 A;  1T67 A;  3MAX A;  3MZ7 A;  5D1D A;  4QA5 A;  5G0Y A;  2GH6 A;  1VKG A;  4QA6 A;  4QA0 A;  1ZZ0 A;  1C3S A;  4RN1 A;  5EEF A;  3ZNS A;  5THU A;  5A2S A;  5DC8 A;  4ZUR A;  3Q9F A;  2V5X A;  4QA1 A;  3MZ4 A;  5FCW A;  4LY1 A;  5DC7 A;  4QA7 A;  4CBT A;  3Q9B A;  5THT A;  4QA4 A;  3EZP A;  4ZUO A;  2VQV A; 
#chains in the Genus database with same CATH topology
 5G0H A;  4HZE A;  1WVB A;  4MYK A;  3MFW A;  5G1C A;  5EF7 A;  1T4S A;  4RHQ A;  5EEM A;  5JI5 A;  5THV A;  1D3V A;  1T69 A;  5EF8 A;  3SFH A;  3Q9E A;  3THJ A;  2PHA A;  3EWF A;  5RLA A;  4QA3 A;  1WVA A;  4RLA A;  1P8P A;  2CEV A;  5D1C A;  4RN0 A;  2RLA A;  4CBY A;  1C3R A;  5ICN B;  5CEV A;  4BZ6 A;  4DZ4 A;  4HWW A;  1HQF A;  3DJ8 A;  5EFH A;  1CEV A;  4IU0 A;  1P8M A;  4CEV A;  1ZZ1 A;  3PZL A;  2VQJ A;  1WOH A;  3C10 A;  4FCK A;  4RN2 A;  4ITY A;  5EEN A;  4ZUN A;  5G0X A;  4Q3Q A;  4Q40 A;  5BWZ A;  4QA2 A;  4BZ9 A;  4ZUP A;  5IWG A;  3KV2 A;  5G10 A;  1T4T A;  3TF3 A;  2VQO A;  5DC6 A;  4CQF A;  5EEI A;  3SJT A;  1GQ6 A;  4Q3T A;  1TBH A;  2PLL A;  1RLA A;  3EW8 A;  5DC5 A;  4RHI A;  3SFF A;  1P8O A;  3THH A;  1T64 A;  4ZUO A;  2VQM A;  5EFN A;  5G0J A;  3C0Y A;  5G13 A;  3MZ3 A;  4ZUM A;  1PQ3 A;  3F80 A;  5D1B A;  3F07 A;  1W22 A;  3F0R A;  4IXU A;  4Q3P A;  3E6V A;  5THS A;  4IE2 A;  4BZ7 A;  3F06 A;  1ZZ3 A;  2ZAV A;  3LP4 A;  5EFB D;  5EFJ D;  2VQW G;  5G11 A;  1HQG A;  4IE3 A;  3RLA A;  4RHJ A;  4BZ8 A;  4RHL A;  4BZ5 A;  4Q3U A;  1T5G A;  2VCG A;  4Q42 A;  2V5W A;  2AEB A;  2EF5 A;  1ZPE A;  3ZNR A;  5G1B A;  3TH7 A;  4MYN A;  5IX0 A;  5EFG A;  1WOG A;  4IU1 A;  3M1R A;  1P8R A;  1HQH A;  4IE1 A;  4LXZ A;  1P8S A;  1T5F A;  3CEV A;  4IU4 A;  4MYL A;  3GN0 A;  5EEK A;  5G0G A;  5G17 A;  5G0I A;  3C0Z A;  5HJA A;  3SKK A;  3RQD A;  3MEN A;  1TA1 A;  2PHO A;  3Q9C A;  5G3W A;  4Q3R A;  1C3P A;  1TBJ A;  4BKX B;  2EIV A;  3SL0 A;  3NIQ A;  5FUE A;  1GQ7 A;  5G1A A;  5EFK B;  3E8Q A;  2VQQ A;  3EZT A;  3MZ6 A;  4ZUQ A;  4A69 A;  5G12 A;  4I06 A;  1T67 A;  3MAX A;  3GMZ A;  1HQX A;  4MYF A;  3E6K A;  3MZ7 A;  1P8N A;  5LI3 A;  1ZPG A;  1WOI A;  5D1D A;  4G3H A;  4QA5 A;  4Q3V A;  5G0Y A;  2GH6 A;  1VKG A;  4QA6 A;  4GSZ A;  4QA0 A;  1TBL A;  1ZZ0 A;  4Q41 A;  1R1O A;  1C3S A;  4Q3R C;  4RN1 A;  3MJL A;  3E9B A;  3LHL A;  5EEF A;  2A0M A;  3ZNS A;  4MXR A;  5THU A;  4GWC A;  5A2S A;  5DC8 A;  3THE A;  2EF4 A;  1XFK A;  4ZUR A;  3SL1 A;  4IXV A;  3MMR A;  3NIO A;  3LP7 A;  3Q9F A;  4FCI A;  4GSM A;  2V5X A;  3MFV A;  4HXQ A;  5HJ9 A;  4RHK A;  4QA1 A;  4GSV A;  1T4R A;  3MZ4 A;  1HQ5 A;  5FCW A;  4LY1 A;  3E8Z A;  4RHM A;  3NIP A;  5DC7 A;  4GWD A;  1T4P A;  4QA7 A;  4CBT A;  3Q9B A;  1P8Q A;  5THT A;  4Q3S A;  4QA4 A;  3EZP A;  4IU5 A;  2VQV A; 
#chains in the Genus database with same CATH homology
 5G0H A;  5G1C A;  5EF7 A;  5EEM A;  5JI5 A;  5THV A;  5EF8 A;  1T69 A;  3SFH A;  3Q9E A;  3EWF A;  4QA3 A;  5D1C A;  4RN0 A;  4CBY A;  1C3R A;  5ICN B;  4BZ6 A;  5EFH A;  1ZZ1 A;  4RN2 A;  2VQJ A;  3C10 A;  5EEN A;  4ZUN A;  5BWZ A;  5G0X A;  4QA2 A;  4BZ9 A;  4ZUP A;  5IWG A;  5G10 A;  2VQO A;  5DC6 A;  4CQF A;  5EEI A;  3EW8 A;  5DC5 A;  3SFF A;  1T64 A;  2VQM A;  5EFN A;  5G0J A;  3C0Y A;  5G13 A;  3MZ3 A;  4ZUM A;  5D1B A;  3F07 A;  1W22 A;  3F0R A;  5THS A;  4BZ7 A;  3F06 A;  1ZZ3 A;  5EFB D;  5EFJ D;  2VQW G;  5G11 A;  4BZ5 A;  4BZ8 A;  2VCG A;  2V5W A;  3ZNR A;  5G1B A;  5IX0 A;  5EFG A;  4LXZ A;  5G0G A;  5G0I A;  5EEK A;  5G17 A;  5LI3 A;  3C0Z A;  3RQD A;  3MEN A;  3Q9C A;  5G3W A;  1C3P A;  4BKX B;  5FUE A;  5G1A A;  5EFK B;  2VQQ A;  3EZT A;  3MZ6 A;  4ZUQ A;  4A69 A;  5G12 A;  1T67 A;  3MAX A;  3MZ7 A;  5D1D A;  4QA5 A;  5G0Y A;  2GH6 A;  1VKG A;  4QA6 A;  4QA0 A;  1ZZ0 A;  1C3S A;  4RN1 A;  5EEF A;  3ZNS A;  5THU A;  5A2S A;  5DC8 A;  4ZUR A;  3Q9F A;  2V5X A;  4QA1 A;  3MZ4 A;  5FCW A;  4LY1 A;  5DC7 A;  4QA7 A;  4CBT A;  3Q9B A;  5THT A;  4QA4 A;  3EZP A;  4ZUO A;  2VQV A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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5A2SA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations