The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
122
|
sequence length |
364
|
structure length |
356
|
Chain Sequence |
LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGEYGLGYDCPATEGIFDYAAAIGEATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| molecule tags |
Hydrolase
|
| molecule keywords |
Histone deacetylase 8
|
| publication title |
Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders.
pubmed doi rcsb |
| source organism |
Homo sapiens
|
| total genus |
122
|
| structure length |
356
|
| sequence length |
364
|
| chains with identical sequence |
B
|
| ec nomenclature |
ec
3.5.1.98: Histone deacetylase. |
| pdb deposition date | 2015-08-04 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00850 | Hist_deacetyl | Histone deacetylase domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | 3-Layer(aba) Sandwich | Arginase; Chain A | Histone deacetylase domain |
#chains in the Genus database with same CATH superfamily 5JI5 A; 1C3P A; 4CBT A; 5G12 A; 5G0I A; 5EFB D; 4RN1 A; 3F0R A; 2VQO A; 3EW8 A; 5EEK A; 5THT A; 5ICN B; 3MZ4 A; 5LI3 A; 1T64 A; 5G0J A; 5DC6 A; 2VQV A; 5THS A; 1ZZ3 A; 4BZ5 A; 4RN2 A; 4ZUR A; 5EEM A; 3MZ7 A; 5THV A; 3ZNR A; 5EFK B; 3EZT A; 5EEI A; 3MAX A; 4ZUQ A; 4BZ9 A; 4QA5 A; 4QA4 A; 5G1C A; 3RQD A; 4ZUO A; 5G0X A; 3ZNS A; 3C10 A; 5D1D A; 5FCW A; 4QA1 A; 5G13 A; 4BKX B; 3SFF A; 3MEN A; 1C3S A; 5FUE A; 4ZUN A; 4LXZ A; 3EWF A; 4QA2 A; 4QA7 A; 4QA6 A; 5EF8 A; 3Q9E A; 5G11 A; 3Q9F A; 5EFN A; 4BZ8 A; 5G17 A; 4CQF A; 3Q9B A; 5D1C A; 4BZ6 A; 4ZUP A; 4ZUM A; 5A2S A; 5EEF A; 4QA0 A; 5G0H A; 5IX0 A; 3SFH A; 5G1A A; 5G0G A; 5IWG A; 5EFG A; 5G3W A; 4BZ7 A; 4A69 A; 1ZZ1 A; 2V5W A; 4CBY A; 4LY1 A; 5EF7 A; 1W22 A; 1ZZ0 A; 3C0Z A; 3C0Y A; 3MZ6 A; 1VKG A; 5G0Y A; 5G1B A; 2GH6 A; 5DC8 A; 2VQJ A; 3MZ3 A; 4QA3 A; 3F06 A; 5BWZ A; 1C3R A; 3EZP A; 5EFJ D; 5D1B A; 1T67 A; 3F07 A; 2VQW G; 5EFH A; 5THU A; 4RN0 A; 2V5X A; 5G10 A; 5DC7 A; 3Q9C A; 2VQQ A; 2VQM A; 5EEN A; 5DC5 A; 1T69 A; 2VCG A; #chains in the Genus database with same CATH topology 5JI5 A; 1C3P A; 4CBT A; 5G12 A; 2CEV A; 5G0I A; 5EFB D; 3THE A; 3GMZ A; 4RN1 A; 3E9B A; 1TA1 A; 1HQF A; 1P8Q A; 3F0R A; 4IE3 A; 4MYN A; 1T5G A; 2VQO A; 3EW8 A; 4RHI A; 5EEK A; 5THT A; 3MZ4 A; 5ICN B; 4IU5 A; 1T64 A; 3PZL A; 5G0J A; 4RHK A; 5LI3 A; 5DC6 A; 1WVB A; 3SL0 A; 2PLL A; 2VQV A; 2PHA A; 5THS A; 1ZZ3 A; 4Q3P A; 4BZ5 A; 4Q3R C; 4HWW A; 4RN2 A; 4ZUR A; 3KV2 A; 1T4P A; 3MMR A; 3F80 A; 3MZ7 A; 5EEM A; 5THV A; 3ZNR A; 5EFK B; 3EZT A; 3LHL A; 5EEI A; 4MXR A; 3E6V A; 1HQX A; 3MAX A; 4ZUQ A; 4Q40 A; 1T4R A; 4BZ9 A; 2EF5 A; 1XFK A; 4QA5 A; 1ZPE A; 4QA4 A; 5G1C A; 3RQD A; 4ZUO A; 4Q3V A; 1T5F A; 3E8Q A; 3M1R A; 5G0X A; 3ZNS A; 1P8P A; 3C10 A; 4GSV A; 5D1D A; 4RHJ A; 5FCW A; 2RLA A; 4QA1 A; 5G13 A; 3SKK A; 4BKX B; 3MFV A; 4ITY A; 1CEV A; 1WOG A; 3MEN A; 4RHL A; 3SFF A; 1C3S A; 5FUE A; 3RLA A; 1RLA A; 1PQ3 A; 1TBH A; 1D3V A; 4LXZ A; 3EWF A; 4ZUN A; 1P8O A; 4QA2 A; 5HJ9 A; 4QA7 A; 1P8N A; 3MFW A; 4GSZ A; 4QA6 A; 3THJ A; 4GSM A; 5EF8 A; 4MYK A; 3Q9E A; 3DJ8 A; 4Q42 A; 5G11 A; 3Q9F A; 5EFN A; 4BZ8 A; 5G17 A; 2AEB A; 3Q9B A; 4CQF A; 5D1C A; 4MYF A; 4BZ6 A; 3TF3 A; 3CEV A; 4ZUP A; 4ZUM A; 5A2S A; 3NIP A; 4CEV A; 4QA0 A; 1HQ5 A; 5EEF A; 2EF4 A; 3NIQ A; 5G0H A; 5IX0 A; 2EIV A; 3SFH A; 4FCI A; 5G1A A; 1T4S A; 4Q3Q A; 3E6K A; 5G0G A; 1P8S A; 5IWG A; 1R1O A; 1WOH A; 5EFG A; 5G3W A; 4BZ7 A; 4DZ4 A; 1HQG A; 4A69 A; 1ZPG A; 4FCK A; 3THH A; 1ZZ1 A; 5RLA A; 2V5W A; 4RLA A; 4LY1 A; 4CBY A; 1GQ6 A; 5EF7 A; 1W22 A; 1ZZ0 A; 3GN0 A; 4IXU A; 3C0Z A; 2PHO A; 3E8Z A; 3C0Y A; 3MZ6 A; 1GQ7 A; 1WVA A; 1VKG A; 5G0Y A; 5G1B A; 1P8M A; 3SL1 A; 2GH6 A; 1P8R A; 5DC8 A; 2VQJ A; 3MZ3 A; 3LP4 A; 4QA3 A; 3F06 A; 1TBJ A; 2ZAV A; 5BWZ A; 1C3R A; 4Q3R A; 3EZP A; 5EFJ D; 3MJL A; 4MYL A; 5D1B A; 4GWD A; 1T67 A; 4HXQ A; 4Q41 A; 4I06 A; 3F07 A; 4GWC A; 2VQW G; 5CEV A; 3TH7 A; 4RHQ A; 1HQH A; 4IU1 A; 4IXV A; 4IU4 A; 4Q3T A; 4RHM A; 4Q3S A; 5EFH A; 5THU A; 3SJT A; 4IU0 A; 1WOI A; 4RN0 A; 2V5X A; 5G10 A; 1TBL A; 5DC7 A; 3Q9C A; 4G3H A; 2VQQ A; 1T4T A; 5HJA A; 4HZE A; 2VQM A; 4IE1 A; 4IE2 A; 3LP7 A; 5EEN A; 3NIO A; 4Q3U A; 5DC5 A; 1T69 A; 2A0M A; 2VCG A; #chains in the Genus database with same CATH homology 5JI5 A; 1C3P A; 4CBT A; 5G12 A; 5G0I A; 5EFB D; 4RN1 A; 3F0R A; 2VQO A; 3EW8 A; 5EEK A; 5THT A; 5ICN B; 3MZ4 A; 5LI3 A; 1T64 A; 5G0J A; 5DC6 A; 2VQV A; 5THS A; 1ZZ3 A; 4BZ5 A; 4RN2 A; 4ZUR A; 5EEM A; 3MZ7 A; 5THV A; 3ZNR A; 5EFK B; 3EZT A; 5EEI A; 3MAX A; 4ZUQ A; 4BZ9 A; 4QA5 A; 4QA4 A; 5G1C A; 3RQD A; 4ZUO A; 5G0X A; 3ZNS A; 3C10 A; 5D1D A; 5FCW A; 4QA1 A; 5G13 A; 4BKX B; 3SFF A; 3MEN A; 1C3S A; 5FUE A; 4ZUN A; 4LXZ A; 3EWF A; 4QA2 A; 4QA7 A; 4QA6 A; 5EF8 A; 3Q9E A; 5G11 A; 3Q9F A; 5EFN A; 4BZ8 A; 5G17 A; 4CQF A; 3Q9B A; 5D1C A; 4BZ6 A; 4ZUP A; 4ZUM A; 5A2S A; 5EEF A; 4QA0 A; 5G0H A; 5IX0 A; 3SFH A; 5G1A A; 5G0G A; 5IWG A; 5EFG A; 5G3W A; 4BZ7 A; 4A69 A; 1ZZ1 A; 2V5W A; 4CBY A; 4LY1 A; 5EF7 A; 1W22 A; 1ZZ0 A; 3C0Z A; 3C0Y A; 3MZ6 A; 1VKG A; 5G0Y A; 5G1B A; 2GH6 A; 5DC8 A; 2VQJ A; 3MZ3 A; 4QA3 A; 3F06 A; 5BWZ A; 1C3R A; 3EZP A; 5EFJ D; 5D1B A; 1T67 A; 3F07 A; 2VQW G; 5EFH A; 5THU A; 4RN0 A; 2V5X A; 5G10 A; 5DC7 A; 3Q9C A; 2VQQ A; 2VQM A; 5EEN A; 5DC5 A; 1T69 A; 2VCG A;
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