5EF8A

Crystal structure of danio rerio histone deacetylase 6 catalytic domain 2 in complex with panobinostat
Total Genus 143
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
143
sequence length
357
structure length
357
Chain Sequence
PITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGDSPPSLDHLTPLKTSATVSINNVLRAHAPFWSSLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Hdac6 protein
publication title Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
pubmed doi rcsb
source organism Danio rerio
total genus 143
structure length 357
sequence length 357
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2015-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5ef8A00
5FCWA 5DC6A 5JI5A 4QA4A 4LXZA 4QA2A 3Q9EA 5G3WA 5ICNB 2V5XA 5EEIA 1T67A 4QA7A 4ZUOA 4BKXB 5EFJD 4RN0A 4ZUQA 5EF8A 3SFHA 5THVA 4QA1A 3MZ3A 5G0HA 1C3SA 5G13A 2VQQA 1C3PA 5DC8A 3C0ZA 5THTA 3RQDA 5DC5A 5EF7A 4ZUNA 4CBYA 4QA3A 5D1CA 5G17A 5EEFA 5BWZA 3EW8A 5EEMA 3F06A 3MZ4A 4LY1A 5THUA 5EEKA 4BZ9A 2VQOA 4RN2A 2VQMA 3Q9CA 1VKGA 4RN1A 3F0RA 5G11A 3MZ7A 1ZZ0A 3F07A 4ZURA 4CBTA 2V5WA 4ZUPA 5G1CA 1C3RA 3SFFA 1ZZ3A 5EFKB 5LI3A 4BZ6A 4QA6A 5G0XA 3Q9FA 5EFBD 5D1DA 4BZ7A 3Q9BA 2VCGA 4CQFA 3MZ6A 1ZZ1A 4QA5A 2GH6A 2VQWG 1T64A 3ZNRA 5IX0A 3C10A 4BZ8A 4A69A 2VQVA 4BZ5A 3EZTA 5A2SA 5EENA 5D1BA 3ZNSA 5G1AA 4QA0A 5G10A 5G1BA 3C0YA 5G12A 5IWGA 5G0IA 1W22A 2VQJA 4ZUMA 5G0GA 5EFHA 5DC7A 3EWFA 3MAXA 3EZPA 1T69A 5G0YA 5FUEA 5EFGA 5G0JA 5THSA 5EFNA 3MENA
chains in the Genus database with same CATH superfamily
4Q3UA 1WOHA 3E6VA 5FCWA 5DC6A 5JI5A 4QA4A 3LP4A 4LXZA 4G3HA 4QA2A 3Q9EA 1T4RA 3NIOA 4RHMA 5G3WA 5ICNB 2V5XA 4IE2A 1TBJA 2PHAA 4GSVA 4CEVA 5EEIA 1T67A 3LP7A 1RLAA 1HQFA 1HQXA 4MYKA 4QA7A 4ZUOA 4BKXB 5EFJD 3KV2A 4RN0A 4ZUQA 5CEVA 5EF8A 4IU1A 3THEA 3SFHA 5THVA 4QA1A 3MZ3A 5G0HA 4HWWA 4Q40A 3NIQA 3SKKA 4I06A 1C3SA 5G13A 1CEVA 2VQQA 1C3PA 5DC8A 3C0ZA 5THTA 3THHA 4GWDA 3RQDA 5DC5A 5EF7A 4ZUNA 3TF3A 4RHKA 4CBYA 1HQ5A 4Q3SA 4RHLA 4RHQA 4QA3A 1P8SA 5D1CA 4Q3RA 5G17A 2EF4A 5EEFA 1ZPGA 5BWZA 1WVBA 3EW8A 1GQ7A 4Q3VA 3GN0A 5EEMA 1P8NA 2A0MA 2EF5A 4Q3PA 1P8MA 3DJ8A 4IE1A 4RHIA 3F06A 4Q41A 3MZ4A 1TBHA 4LY1A 5THUA 4GWCA 4FCKA 3THJA 5EEKA 4BZ9A 2VQOA 4RN2A 2VQMA 3Q9CA 3TH7A 1VKGA 3LHLA 3M1RA 3SL1A 4RN1A 3F0RA 3SJTA 4FCIA 1R1OA 1T4TA 3GMZA 4MYNA 1GQ6A 4IE3A 4Q3RC 5G11A 3MZ7A 4IU5A 1ZZ0A 3F07A 4ZURA 1D3VA 3F80A 2V5WA 4ZUPA 4CBTA 5G1CA 1C3RA 3SFFA 1ZZ3A 2AEBA 5EFKB 5LI3A 1TA1A 3NIPA 4BZ6A 4QA6A 1P8PA 5G0XA 3Q9FA 3CEVA 3RLAA 4DZ4A 3E6KA 3E9BA 5EFBD 4Q3QA 1XFKA 5D1DA 4BZ7A 3Q9BA 3E8QA 4HZEA 2CEVA 2VCGA 4CQFA 2EIVA 3MZ6A 1P8RA 1ZZ1A 4QA5A 1HQGA 2GH6A 1P8OA 1P8QA 2VQWG 3E8ZA 3MFWA 4RHJA 1T64A 4IU4A 3SL0A 3ZNRA 5IX0A 3MJLA 3C10A 4Q3TA 4GSZA 4A69A 2VQVA 4BZ8A 1WVAA 5RLAA 3EZTA 4BZ5A 5A2SA 1TBLA 5EENA 5D1BA 1PQ3A 1T5FA 5HJ9A 3ZNSA 4MYFA 5G1AA 1HQHA 2PLLA 4QA0A 1WOGA 5G10A 1T5GA 5G1BA 2ZAVA 3C0YA 4MXRA 1WOIA 3MMRA 3PZLA 3MFVA 1T4PA 5G12A 5IWGA 5G0IA 1ZPEA 4IXVA 1W22A 2VQJA 5HJAA 4ZUMA 1T4SA 4ITYA 5G0GA 4IXUA 5EFHA 4IU0A 5DC7A 3EWFA 3MAXA 2PHOA 3EZPA 4GSMA 1T69A 5G0YA 5FUEA 5EFGA 2RLAA 5G0JA 5THSA 5EFNA 4RLAA 4MYLA 4Q42A 3MENA 4HXQA
chains in the Genus database with same CATH topology
5FCWA 5DC6A 5JI5A 4QA4A 4LXZA 4QA2A 3Q9EA 5G3WA 5ICNB 2V5XA 5EEIA 1T67A 4QA7A 4ZUOA 4BKXB 5EFJD 4RN0A 4ZUQA 5EF8A 3SFHA 5THVA 4QA1A 3MZ3A 5G0HA 1C3SA 5G13A 2VQQA 1C3PA 5DC8A 3C0ZA 5THTA 3RQDA 5DC5A 5EF7A 4ZUNA 4CBYA 4QA3A 5D1CA 5G17A 5EEFA 5BWZA 3EW8A 5EEMA 3F06A 3MZ4A 4LY1A 5THUA 5EEKA 4BZ9A 2VQOA 4RN2A 2VQMA 3Q9CA 1VKGA 4RN1A 3F0RA 5G11A 3MZ7A 1ZZ0A 3F07A 4ZURA 4CBTA 2V5WA 4ZUPA 5G1CA 1C3RA 3SFFA 1ZZ3A 5EFKB 5LI3A 4BZ6A 4QA6A 5G0XA 3Q9FA 5EFBD 5D1DA 4BZ7A 3Q9BA 2VCGA 4CQFA 3MZ6A 1ZZ1A 4QA5A 2GH6A 2VQWG 1T64A 3ZNRA 5IX0A 3C10A 4BZ8A 4A69A 2VQVA 4BZ5A 3EZTA 5A2SA 5EENA 5D1BA 3ZNSA 5G1AA 4QA0A 5G10A 5G1BA 3C0YA 5G12A 5IWGA 5G0IA 1W22A 2VQJA 4ZUMA 5G0GA 5EFHA 5DC7A 3EWFA 3MAXA 3EZPA 1T69A 5G0YA 5FUEA 5EFGA 5G0JA 5THSA 5EFNA 3MENA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5FCW A;  5DC6 A;  5JI5 A;  4QA4 A;  4LXZ A;  4QA2 A;  3Q9E A;  5G3W A;  5ICN B;  2V5X A;  5EEI A;  1T67 A;  4QA7 A;  4ZUO A;  4BKX B;  5EFJ D;  4RN0 A;  4ZUQ A;  5EF8 A;  3SFH A;  5THV A;  4QA1 A;  3MZ3 A;  5G0H A;  1C3S A;  5G13 A;  2VQQ A;  1C3P A;  5DC8 A;  3C0Z A;  5THT A;  3RQD A;  5DC5 A;  5EF7 A;  4ZUN A;  4CBY A;  4QA3 A;  5D1C A;  5G17 A;  5EEF A;  5BWZ A;  3EW8 A;  5EEM A;  3F06 A;  3MZ4 A;  4LY1 A;  5THU A;  5EEK A;  4BZ9 A;  2VQO A;  4RN2 A;  2VQM A;  3Q9C A;  1VKG A;  4RN1 A;  3F0R A;  5G11 A;  3MZ7 A;  1ZZ0 A;  3F07 A;  4ZUR A;  4CBT A;  2V5W A;  4ZUP A;  5G1C A;  1C3R A;  3SFF A;  1ZZ3 A;  5EFK B;  5LI3 A;  4BZ6 A;  4QA6 A;  5G0X A;  3Q9F A;  5EFB D;  5D1D A;  4BZ7 A;  3Q9B A;  2VCG A;  4CQF A;  3MZ6 A;  1ZZ1 A;  4QA5 A;  2GH6 A;  2VQW G;  1T64 A;  3ZNR A;  5IX0 A;  3C10 A;  4BZ8 A;  4A69 A;  2VQV A;  4BZ5 A;  3EZT A;  5A2S A;  5EEN A;  5D1B A;  3ZNS A;  5G1A A;  4QA0 A;  5G10 A;  5G1B A;  3C0Y A;  5G12 A;  5IWG A;  5G0I A;  1W22 A;  2VQJ A;  4ZUM A;  5G0G A;  5EFH A;  5DC7 A;  3EWF A;  3MAX A;  3EZP A;  1T69 A;  5G0Y A;  5FUE A;  5EFG A;  5G0J A;  5THS A;  5EFN A;  3MEN A; 
#chains in the Genus database with same CATH topology
 4Q3U A;  1WOH A;  3E6V A;  5FCW A;  5DC6 A;  5JI5 A;  4QA4 A;  3LP4 A;  4LXZ A;  4G3H A;  4QA2 A;  3Q9E A;  1T4R A;  3NIO A;  4RHM A;  5G3W A;  5ICN B;  2V5X A;  4IE2 A;  1TBJ A;  2PHA A;  4GSV A;  4CEV A;  5EEI A;  1T67 A;  3LP7 A;  1RLA A;  1HQF A;  1HQX A;  4MYK A;  4QA7 A;  4ZUO A;  4BKX B;  5EFJ D;  3KV2 A;  4RN0 A;  4ZUQ A;  5CEV A;  5EF8 A;  4IU1 A;  3THE A;  3SFH A;  5THV A;  4QA1 A;  3MZ3 A;  5G0H A;  4HWW A;  4Q40 A;  3NIQ A;  3SKK A;  4I06 A;  1C3S A;  5G13 A;  1CEV A;  2VQQ A;  1C3P A;  5DC8 A;  3C0Z A;  5THT A;  3THH A;  4GWD A;  3RQD A;  5DC5 A;  5EF7 A;  4ZUN A;  3TF3 A;  4RHK A;  4CBY A;  1HQ5 A;  4Q3S A;  4RHL A;  4RHQ A;  4QA3 A;  1P8S A;  5D1C A;  4Q3R A;  5G17 A;  2EF4 A;  5EEF A;  1ZPG A;  5BWZ A;  1WVB A;  3EW8 A;  1GQ7 A;  4Q3V A;  3GN0 A;  5EEM A;  1P8N A;  2A0M A;  2EF5 A;  4Q3P A;  1P8M A;  3DJ8 A;  4IE1 A;  4RHI A;  3F06 A;  4Q41 A;  3MZ4 A;  1TBH A;  4LY1 A;  5THU A;  4GWC A;  4FCK A;  3THJ A;  5EEK A;  4BZ9 A;  2VQO A;  4RN2 A;  2VQM A;  3Q9C A;  3TH7 A;  1VKG A;  3LHL A;  3M1R A;  3SL1 A;  4RN1 A;  3F0R A;  3SJT A;  4FCI A;  1R1O A;  1T4T A;  3GMZ A;  4MYN A;  1GQ6 A;  4IE3 A;  4Q3R C;  5G11 A;  3MZ7 A;  4IU5 A;  1ZZ0 A;  3F07 A;  4ZUR A;  1D3V A;  3F80 A;  2V5W A;  4ZUP A;  4CBT A;  5G1C A;  1C3R A;  3SFF A;  1ZZ3 A;  2AEB A;  5EFK B;  5LI3 A;  1TA1 A;  3NIP A;  4BZ6 A;  4QA6 A;  1P8P A;  5G0X A;  3Q9F A;  3CEV A;  3RLA A;  4DZ4 A;  3E6K A;  3E9B A;  5EFB D;  4Q3Q A;  1XFK A;  5D1D A;  4BZ7 A;  3Q9B A;  3E8Q A;  4HZE A;  2CEV A;  2VCG A;  4CQF A;  2EIV A;  3MZ6 A;  1P8R A;  1ZZ1 A;  4QA5 A;  1HQG A;  2GH6 A;  1P8O A;  1P8Q A;  2VQW G;  3E8Z A;  3MFW A;  4RHJ A;  1T64 A;  4IU4 A;  3SL0 A;  3ZNR A;  5IX0 A;  3MJL A;  3C10 A;  4Q3T A;  4GSZ A;  4A69 A;  2VQV A;  4BZ8 A;  1WVA A;  5RLA A;  3EZT A;  4BZ5 A;  5A2S A;  1TBL A;  5EEN A;  5D1B A;  1PQ3 A;  1T5F A;  5HJ9 A;  3ZNS A;  4MYF A;  5G1A A;  1HQH A;  2PLL A;  4QA0 A;  1WOG A;  5G10 A;  1T5G A;  5G1B A;  2ZAV A;  3C0Y A;  4MXR A;  1WOI A;  3MMR A;  3PZL A;  3MFV A;  1T4P A;  5G12 A;  5IWG A;  5G0I A;  1ZPE A;  4IXV A;  1W22 A;  2VQJ A;  5HJA A;  4ZUM A;  1T4S A;  4ITY A;  5G0G A;  4IXU A;  5EFH A;  4IU0 A;  5DC7 A;  3EWF A;  3MAX A;  2PHO A;  3EZP A;  4GSM A;  1T69 A;  5G0Y A;  5FUE A;  5EFG A;  2RLA A;  5G0J A;  5THS A;  5EFN A;  4RLA A;  4MYL A;  4Q42 A;  3MEN A;  4HXQ A; 
#chains in the Genus database with same CATH homology
 5FCW A;  5DC6 A;  5JI5 A;  4QA4 A;  4LXZ A;  4QA2 A;  3Q9E A;  5G3W A;  5ICN B;  2V5X A;  5EEI A;  1T67 A;  4QA7 A;  4ZUO A;  4BKX B;  5EFJ D;  4RN0 A;  4ZUQ A;  5EF8 A;  3SFH A;  5THV A;  4QA1 A;  3MZ3 A;  5G0H A;  1C3S A;  5G13 A;  2VQQ A;  1C3P A;  5DC8 A;  3C0Z A;  5THT A;  3RQD A;  5DC5 A;  5EF7 A;  4ZUN A;  4CBY A;  4QA3 A;  5D1C A;  5G17 A;  5EEF A;  5BWZ A;  3EW8 A;  5EEM A;  3F06 A;  3MZ4 A;  4LY1 A;  5THU A;  5EEK A;  4BZ9 A;  2VQO A;  4RN2 A;  2VQM A;  3Q9C A;  1VKG A;  4RN1 A;  3F0R A;  5G11 A;  3MZ7 A;  1ZZ0 A;  3F07 A;  4ZUR A;  4CBT A;  2V5W A;  4ZUP A;  5G1C A;  1C3R A;  3SFF A;  1ZZ3 A;  5EFK B;  5LI3 A;  4BZ6 A;  4QA6 A;  5G0X A;  3Q9F A;  5EFB D;  5D1D A;  4BZ7 A;  3Q9B A;  2VCG A;  4CQF A;  3MZ6 A;  1ZZ1 A;  4QA5 A;  2GH6 A;  2VQW G;  1T64 A;  3ZNR A;  5IX0 A;  3C10 A;  4BZ8 A;  4A69 A;  2VQV A;  4BZ5 A;  3EZT A;  5A2S A;  5EEN A;  5D1B A;  3ZNS A;  5G1A A;  4QA0 A;  5G10 A;  5G1B A;  3C0Y A;  5G12 A;  5IWG A;  5G0I A;  1W22 A;  2VQJ A;  4ZUM A;  5G0G A;  5EFH A;  5DC7 A;  3EWF A;  3MAX A;  3EZP A;  1T69 A;  5G0Y A;  5FUE A;  5EFG A;  5G0J A;  5THS A;  5EFN A;  3MEN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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