The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
130
|
sequence length |
365
|
structure length |
364
|
Chain Sequence |
SLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Structure of 'linkerless' hydroxamic acid inhibitor-HDAC8 complex confirms the formation of an isoform-specific subpocket.
pubmed doi rcsb |
| molecule keywords |
Histone deacetylase 8
|
| molecule tags |
Hydrolase
|
| source organism |
Homo sapiens
|
| total genus |
130
|
| structure length |
364
|
| sequence length |
365
|
| chains with identical sequence |
B
|
| ec nomenclature |
ec
3.5.1.98: Histone deacetylase. |
| pdb deposition date | 2015-12-15 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00850 | Hist_deacetyl | Histone deacetylase domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | 3-Layer(aba) Sandwich | Arginase; Chain A | Histone deacetylase domain |
#chains in the Genus database with same CATH superfamily 1W22 A; 5G0H A; 1ZZ1 A; 5D1D A; 4BZ9 A; 4CQF A; 3EZT A; 3SFF A; 3EWF A; 3ZNS A; 5THU A; 5G12 A; 5D1C A; 5IWG A; 4ZUP A; 5FUE A; 4QA4 A; 1C3R A; 5EEK A; 5EFJ D; 1C3S A; 5G3W A; 5G10 A; 4QA2 A; 5EFK B; 5G11 A; 3MEN A; 1VKG A; 4ZUO A; 5THV A; 5EEN A; 4QA1 A; 3C0Y A; 5EFG A; 2VCG A; 5G0J A; 4LXZ A; 5THT A; 5EFB D; 3EW8 A; 5EEI A; 5BWZ A; 5G13 A; 3Q9E A; 4BZ8 A; 4QA7 A; 3F0R A; 2VQW G; 4QA6 A; 1T64 A; 5EFH A; 5D1B A; 3F07 A; 3Q9B A; 2VQV A; 3MZ7 A; 5G1C A; 4BZ5 A; 4QA0 A; 2V5W A; 2VQQ A; 5EF7 A; 3ZNR A; 5G0G A; 3C0Z A; 4RN2 A; 4BKX B; 5FCW A; 4ZUM A; 3MAX A; 4CBY A; 5A2S A; 3C10 A; 3F06 A; 5LI3 A; 5DC6 A; 2V5X A; 3RQD A; 4ZUR A; 4CBT A; 4BZ6 A; 2VQJ A; 3Q9C A; 5ICN B; 4RN0 A; 3Q9F A; 5EEM A; 4ZUN A; 5EEF A; 5DC7 A; 4QA3 A; 4RN1 A; 5DC5 A; 1ZZ0 A; 1T69 A; 5G1A A; 5G0X A; 5JI5 A; 1T67 A; 3MZ3 A; 2VQM A; 3MZ4 A; 5DC8 A; 1ZZ3 A; 4ZUQ A; 4LY1 A; 5G17 A; 5IX0 A; 5THS A; 3SFH A; 3MZ6 A; 5G1B A; 1C3P A; 5EF8 A; 3EZP A; 4QA5 A; 2VQO A; 4BZ7 A; 5G0Y A; 4A69 A; 2GH6 A; 5G0I A; 5EFN A; #chains in the Genus database with same CATH topology 3E8Z A; 1W22 A; 5G0H A; 1ZZ1 A; 5D1D A; 4FCK A; 4BZ9 A; 1P8O A; 4CQF A; 3EZT A; 3SFF A; 3EWF A; 3ZNS A; 5THU A; 4RHL A; 1R1O A; 5G12 A; 2EIV A; 5D1C A; 1T4T A; 3F80 A; 5IWG A; 4ZUP A; 3DJ8 A; 3THE A; 4MXR A; 3SL1 A; 5FUE A; 4QA4 A; 1C3R A; 1T5G A; 5EEK A; 5EFJ D; 1HQ5 A; 1C3S A; 3GMZ A; 5HJ9 A; 1T4P A; 1GQ6 A; 1P8R A; 2PLL A; 5G3W A; 5G10 A; 1TA1 A; 1WVB A; 4QA2 A; 4Q3R C; 1HQF A; 5EFK B; 1HQH A; 5CEV A; 4ITY A; 5G11 A; 1TBJ A; 1VKG A; 3MEN A; 4IE2 A; 4MYF A; 1P8M A; 4I06 A; 4MYL A; 4ZUO A; 3SKK A; 3CEV A; 5THV A; 4GSZ A; 3TH7 A; 4IU1 A; 4DZ4 A; 5EEN A; 3C0Y A; 4QA1 A; 2VCG A; 1XFK A; 5EFG A; 4RHQ A; 5G0J A; 1TBH A; 4LXZ A; 5THT A; 5EFB D; 3EW8 A; 5EEI A; 1P8Q A; 1GQ7 A; 5BWZ A; 5G13 A; 3Q9E A; 4GSM A; 1ZPE A; 4HZE A; 4BZ8 A; 1P8P A; 3MMR A; 3NIQ A; 4QA7 A; 4RHJ A; 1WOG A; 2ZAV A; 3F0R A; 2VQW G; 1T4R A; 4QA6 A; 1T64 A; 4RHI A; 5D1B A; 3F07 A; 3Q9B A; 4Q3Q A; 5EFH A; 1D3V A; 4MYN A; 2A0M A; 1HQX A; 3E9B A; 4Q3V A; 2VQV A; 3MZ7 A; 1T5F A; 4IXU A; 3LHL A; 5G1C A; 4BZ5 A; 1CEV A; 2AEB A; 2CEV A; 4QA0 A; 2V5W A; 4Q40 A; 1TBL A; 4IE1 A; 4CEV A; 2VQQ A; 5EF7 A; 2RLA A; 1WVA A; 3ZNR A; 4Q3R A; 5G0G A; 3C0Z A; 4Q42 A; 4RN2 A; 4BKX B; 1RLA A; 5FCW A; 3MJL A; 4ZUM A; 4RLA A; 1WOH A; 1P8N A; 1HQG A; 3KV2 A; 3MAX A; 3NIO A; 1PQ3 A; 2EF5 A; 4FCI A; 4IU5 A; 4Q3T A; 3E6V A; 4CBY A; 5A2S A; 3C10 A; 4HXQ A; 3THJ A; 3F06 A; 3E6K A; 4RHM A; 3RLA A; 5LI3 A; 3PZL A; 5DC6 A; 2V5X A; 3GN0 A; 3RQD A; 4ZUR A; 3LP7 A; 4GWC A; 4CBT A; 4BZ6 A; 2VQJ A; 3Q9C A; 5ICN B; 1WOI A; 4HWW A; 3Q9F A; 3LP4 A; 4RN0 A; 5EEM A; 4GWD A; 4ZUN A; 4IU0 A; 4Q3S A; 5EEF A; 3NIP A; 4IU4 A; 4IE3 A; 4QA3 A; 1ZZ0 A; 2PHO A; 1T69 A; 3M1R A; 4RN1 A; 5DC7 A; 4Q3U A; 5DC5 A; 5G1A A; 5G0X A; 5JI5 A; 1T67 A; 3SL0 A; 4Q41 A; 3MZ3 A; 2VQM A; 3E8Q A; 3MZ4 A; 1T4S A; 5RLA A; 3MFW A; 4G3H A; 5DC8 A; 1ZZ3 A; 4ZUQ A; 5HJA A; 4LY1 A; 5G17 A; 4GSV A; 4Q3P A; 2PHA A; 2EF4 A; 5IX0 A; 5THS A; 4MYK A; 3SFH A; 3MZ6 A; 5G1B A; 1C3P A; 5EF8 A; 3EZP A; 4QA5 A; 3MFV A; 3TF3 A; 1P8S A; 2VQO A; 4BZ7 A; 4IXV A; 5G0Y A; 4A69 A; 1ZPG A; 4RHK A; 2GH6 A; 5G0I A; 3SJT A; 3THH A; 5EFN A; #chains in the Genus database with same CATH homology 1W22 A; 5G0H A; 1ZZ1 A; 5D1D A; 4BZ9 A; 4CQF A; 3EZT A; 3SFF A; 3EWF A; 3ZNS A; 5THU A; 5G12 A; 5D1C A; 5IWG A; 4ZUP A; 5FUE A; 4QA4 A; 1C3R A; 5EEK A; 5EFJ D; 1C3S A; 5G3W A; 5G10 A; 4QA2 A; 5EFK B; 5G11 A; 3MEN A; 1VKG A; 4ZUO A; 5THV A; 5EEN A; 4QA1 A; 3C0Y A; 5EFG A; 2VCG A; 5G0J A; 4LXZ A; 5THT A; 5EFB D; 3EW8 A; 5EEI A; 5BWZ A; 5G13 A; 3Q9E A; 4BZ8 A; 4QA7 A; 3F0R A; 2VQW G; 4QA6 A; 1T64 A; 5EFH A; 5D1B A; 3F07 A; 3Q9B A; 2VQV A; 3MZ7 A; 5G1C A; 4BZ5 A; 4QA0 A; 2V5W A; 2VQQ A; 5EF7 A; 3ZNR A; 5G0G A; 3C0Z A; 4RN2 A; 4BKX B; 5FCW A; 4ZUM A; 3MAX A; 4CBY A; 5A2S A; 3C10 A; 3F06 A; 5LI3 A; 5DC6 A; 2V5X A; 3RQD A; 4ZUR A; 4CBT A; 4BZ6 A; 2VQJ A; 3Q9C A; 5ICN B; 4RN0 A; 3Q9F A; 5EEM A; 4ZUN A; 5EEF A; 5DC7 A; 4QA3 A; 4RN1 A; 5DC5 A; 1ZZ0 A; 1T69 A; 5G1A A; 5G0X A; 5JI5 A; 1T67 A; 3MZ3 A; 2VQM A; 3MZ4 A; 5DC8 A; 1ZZ3 A; 4ZUQ A; 4LY1 A; 5G17 A; 5IX0 A; 5THS A; 3SFH A; 3MZ6 A; 5G1B A; 1C3P A; 5EF8 A; 3EZP A; 4QA5 A; 2VQO A; 4BZ7 A; 5G0Y A; 4A69 A; 2GH6 A; 5G0I A; 5EFN A;
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