The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
145
|
sequence length |
370
|
structure length |
369
|
Chain Sequence |
HHAIGYVWNTLYGWVDTGTGSLAAANLTARMQPISHHLAHPDTKRRFHELVCASGQIEHLTPIAAVAATDADILRAHSAAHLENMKRVSNLPTGGDTGDGITMMGNGGLEIARLSAGGAVELTRRVATGELSAGYALVNPPGHHAPHNAAMGFCIFNNTSVAAGYARAVLGMERVAILDWDVHHGNGTQDIWWNDPSVLTISLHQHLCFPPDSGYSTERGAGNGHGYNINVPLPPGSGNAAYLHAMDQVVLPALRAYRPQLIIVGSGFDASMLDPLARMMVTADGFRQMARRTIDCAADICDGRIVFVQEGGYSPHYLPFCGLAVIEELTGVRSLPDPYHEFLAGMGGNTLLDAERAAIEIVPLLADIR
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
The thermodynamic signature of ligand binding to histone deacetylase-like amidohydrolases is most sensitive to the flexibility in the L2-loop lining the active site pocket.
pubmed doi rcsb |
| molecule tags |
Hydrolase
|
| source organism |
Alcaligenes
|
| molecule keywords |
HISTONE DEACETYLASE-LIKE AMIDOHYDROLASE
|
| total genus |
145
|
| structure length |
369
|
| sequence length |
370
|
| chains with identical sequence |
B
|
| ec nomenclature |
ec
3.5.1.4: Amidase. |
| pdb deposition date | 2016-03-24 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00850 | Hist_deacetyl | Histone deacetylase domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | 3-Layer(aba) Sandwich | Arginase; Chain A | Histone deacetylase domain |
#chains in the Genus database with same CATH superfamily 5DC7 A; 5EEF A; 3Q9B A; 4QA6 A; 5EF8 A; 4ZUR A; 2VQV A; 4BZ5 A; 4LY1 A; 5DC8 A; 5G1A A; 5EFB D; 5IWG A; 3MEN A; 5EFN A; 5THT A; 3F06 A; 5LI3 A; 3C0Z A; 5DC6 A; 4QA5 A; 2V5W A; 4ZUM A; 4RN2 A; 3F0R A; 5G0H A; 1W22 A; 2VQW G; 3Q9E A; 4BZ7 A; 5A2S A; 1ZZ3 A; 5IX0 A; 3MZ3 A; 4QA7 A; 4QA1 A; 5DC5 A; 5G17 A; 3EWF A; 3EZP A; 3MZ6 A; 5JI5 A; 1VKG A; 3EZT A; 5EEK A; 2GH6 A; 5G12 A; 2V5X A; 1C3S A; 2VQM A; 4A69 A; 5G0X A; 4BKX B; 5ICN B; 4BZ8 A; 4CBY A; 5G1B A; 5EF7 A; 1T64 A; 3SFH A; 2VQJ A; 3MAX A; 5EEM A; 5D1B A; 1T69 A; 5EEN A; 5G10 A; 5G13 A; 4BZ6 A; 4ZUP A; 1C3R A; 5FCW A; 5BWZ A; 5EFJ D; 1ZZ1 A; 5G11 A; 5EFG A; 4BZ9 A; 5G3W A; 5G0I A; 5THS A; 4CBT A; 4QA2 A; 5THV A; 3ZNS A; 2VCG A; 4QA3 A; 5G1C A; 5EFK B; 5EFH A; 1C3P A; 3RQD A; 3EW8 A; 4CQF A; 4ZUO A; 3C10 A; 3MZ7 A; 5THU A; 5D1D A; 4QA0 A; 4LXZ A; 4RN1 A; 2VQQ A; 3F07 A; 3Q9C A; 3C0Y A; 5FUE A; 5D1C A; 5G0G A; 5G0Y A; 3MZ4 A; 5G0J A; 1ZZ0 A; 4RN0 A; 3ZNR A; 1T67 A; 5EEI A; 4QA4 A; 3SFF A; 3Q9F A; 4ZUN A; 4ZUQ A; 2VQO A; #chains in the Genus database with same CATH topology 5DC7 A; 4Q3R A; 5EEF A; 3THJ A; 4HWW A; 3Q9B A; 4QA6 A; 5EF8 A; 3M1R A; 4ZUR A; 2VQV A; 4BZ5 A; 4CEV A; 4LY1 A; 5DC8 A; 4IE3 A; 1TA1 A; 1P8P A; 5G1A A; 5EFB D; 2RLA A; 3MEN A; 5IWG A; 4Q3U A; 3MFW A; 4RHJ A; 5EFN A; 5THT A; 1P8N A; 1HQX A; 1R1O A; 3E8Q A; 2PHA A; 3F06 A; 4IU1 A; 4IXV A; 5LI3 A; 3C0Z A; 4IXU A; 1T4P A; 4MXR A; 5DC6 A; 4QA5 A; 2V5W A; 4GWC A; 4Q3P A; 4ZUM A; 4MYK A; 1WVB A; 3DJ8 A; 4RN2 A; 3F0R A; 5G0H A; 1W22 A; 1GQ6 A; 2VQW G; 3MMR A; 3Q9E A; 1GQ7 A; 4Q3R C; 4BZ7 A; 5A2S A; 1ZZ3 A; 3RLA A; 4Q3V A; 4IU0 A; 3SL1 A; 5IX0 A; 3MZ3 A; 4QA7 A; 4QA1 A; 5DC5 A; 5G17 A; 3EWF A; 2EF4 A; 3EZP A; 3MZ6 A; 3NIO A; 4DZ4 A; 1WOG A; 5JI5 A; 4IU5 A; 1VKG A; 3EZT A; 1HQH A; 2GH6 A; 3MJL A; 4RLA A; 4RHL A; 2V5X A; 5EEK A; 1C3S A; 5G12 A; 1PQ3 A; 4GSZ A; 3TH7 A; 1RLA A; 2VQM A; 2ZAV A; 4MYL A; 5G0X A; 3GMZ A; 4A69 A; 4BKX B; 5ICN B; 1HQG A; 4BZ8 A; 1ZPE A; 3NIP A; 4CBY A; 3SL0 A; 5G1B A; 5EF7 A; 1T64 A; 1P8O A; 1P8R A; 4I06 A; 4RHM A; 3E8Z A; 1T4S A; 2VQJ A; 3LP4 A; 4MYF A; 3SFH A; 3MAX A; 4G3H A; 3PZL A; 4IU4 A; 5EEM A; 5D1B A; 4IE1 A; 5RLA A; 1T69 A; 5HJA A; 2PHO A; 5EEN A; 5G10 A; 1WOI A; 3NIQ A; 1TBH A; 1ZPG A; 5G13 A; 4BZ6 A; 4ZUP A; 1C3R A; 5FCW A; 5BWZ A; 1WOH A; 5EFJ D; 1ZZ1 A; 3GN0 A; 1D3V A; 5G11 A; 5EFG A; 4BZ9 A; 5G3W A; 3TF3 A; 5G0I A; 1WVA A; 5THS A; 4CBT A; 1TBJ A; 4QA2 A; 1T5F A; 4HXQ A; 5THV A; 3ZNS A; 1HQ5 A; 5CEV A; 2VCG A; 2CEV A; 4ITY A; 4QA3 A; 5G1C A; 4FCK A; 1XFK A; 1C3P A; 5EFH A; 5EFK B; 3RQD A; 3EW8 A; 4CQF A; 4ZUO A; 4GSM A; 3C10 A; 2EIV A; 4Q3Q A; 3MZ7 A; 5THU A; 3KV2 A; 3E6V A; 4MYN A; 4Q40 A; 4Q3T A; 5D1D A; 4RHQ A; 3SKK A; 4GWD A; 2EF5 A; 3THH A; 4QA0 A; 4FCI A; 5HJ9 A; 4LXZ A; 4RN1 A; 2VQQ A; 3F07 A; 3Q9C A; 3CEV A; 1P8Q A; 3C0Y A; 5FUE A; 1CEV A; 1TBL A; 4GSV A; 4RHK A; 5D1C A; 5G0G A; 2A0M A; 3F80 A; 3LHL A; 5G0Y A; 3MZ4 A; 1P8S A; 3E9B A; 5G0J A; 1P8M A; 4Q3S A; 1ZZ0 A; 4Q42 A; 3MFV A; 4RN0 A; 4IE2 A; 3SJT A; 1HQF A; 2AEB A; 3ZNR A; 1T67 A; 5EEI A; 4HZE A; 3LP7 A; 1T5G A; 4QA4 A; 3E6K A; 3SFF A; 2PLL A; 1T4T A; 3Q9F A; 4ZUN A; 4ZUQ A; 4RHI A; 4Q41 A; 1T4R A; 3THE A; 2VQO A; #chains in the Genus database with same CATH homology 5DC7 A; 5EEF A; 3Q9B A; 4QA6 A; 5EF8 A; 4ZUR A; 2VQV A; 4BZ5 A; 4LY1 A; 5DC8 A; 5G1A A; 5EFB D; 5IWG A; 3MEN A; 5EFN A; 5THT A; 3F06 A; 5LI3 A; 3C0Z A; 5DC6 A; 4QA5 A; 2V5W A; 4ZUM A; 4RN2 A; 3F0R A; 5G0H A; 1W22 A; 2VQW G; 3Q9E A; 4BZ7 A; 5A2S A; 1ZZ3 A; 5IX0 A; 3MZ3 A; 4QA7 A; 4QA1 A; 5DC5 A; 5G17 A; 3EWF A; 3EZP A; 3MZ6 A; 5JI5 A; 1VKG A; 3EZT A; 5EEK A; 2GH6 A; 5G12 A; 2V5X A; 1C3S A; 2VQM A; 4A69 A; 5G0X A; 4BKX B; 5ICN B; 4BZ8 A; 4CBY A; 5G1B A; 5EF7 A; 1T64 A; 3SFH A; 2VQJ A; 3MAX A; 5EEM A; 5D1B A; 1T69 A; 5EEN A; 5G10 A; 5G13 A; 4BZ6 A; 4ZUP A; 1C3R A; 5FCW A; 5BWZ A; 5EFJ D; 1ZZ1 A; 5G11 A; 5EFG A; 4BZ9 A; 5G3W A; 5G0I A; 5THS A; 4CBT A; 4QA2 A; 5THV A; 3ZNS A; 2VCG A; 4QA3 A; 5G1C A; 5EFK B; 5EFH A; 1C3P A; 3RQD A; 3EW8 A; 4CQF A; 4ZUO A; 3C10 A; 3MZ7 A; 5THU A; 5D1D A; 4QA0 A; 4LXZ A; 4RN1 A; 2VQQ A; 3F07 A; 3Q9C A; 3C0Y A; 5FUE A; 5D1C A; 5G0G A; 5G0Y A; 3MZ4 A; 5G0J A; 1ZZ0 A; 4RN0 A; 3ZNR A; 1T67 A; 5EEI A; 4QA4 A; 3SFF A; 3Q9F A; 4ZUN A; 4ZUQ A; 2VQO A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
