5THU | Genus

Total Genus 134

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	134
sequence length	365
structure length	358
Chain Sequence	LVPVYIYSPEYVSMCDSKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGAGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVVI

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hydrolase
source organism	Homo sapiens
publication title	Structural and Functional Influence of the Glycine-Rich Loop G302GGGY on the Catalytic Tyrosine of Histone Deacetylase 8. pubmed doi rcsb
molecule keywords	Histone deacetylase 8
total genus	134
structure length	358
sequence length	365
chains with identical sequence	B
ec nomenclature	ec 3.5.1.98: Histone deacetylase.
pdb deposition date	2016-09-30

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00850	Hist_deacetyl	Histone deacetylase domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.800.20	Alpha Beta	3-Layer(aba) Sandwich	Arginase; Chain A	Histone deacetylase domain	5thuA00

4RN0A 5EFHA 5EEFA 2VQVA 4QA3A 5G11A 1C3RA 3Q9CA 1T69A 2V5XA 3C0YA 1C3SA 3C10A 5G1BA 5THVA 4RN2A 3C0ZA 5G10A 5THSA 3F0RA 3MZ6A 5EFGA 5EEMA 5THTA 5G0IA 4BZ8A 3F06A 4QA0A 2GH6A 4ZUNA 5EENA 3Q9EA 5G17A 4BZ7A 5G12A 4ZUMA 2VQOA 4QA6A 1ZZ0A 5EEKA 4BZ5A 4ZUQA 3MZ3A 3ZNSA 3RQDA 3ZNRA 5EFNA 4CBTA 1VKGA 3SFFA 4BZ6A 4QA7A 5EF7A 5BWZA 1ZZ1A 3MZ7A 5FCWA 5EEIA 5DC6A 5EFKB 3Q9FA 3MENA 5EFJD 2VQJA 1W22A 3EWFA 5DC7A 5EF8A 2VQQA 2VCGA 4LY1A 1ZZ3A 5EFBD 5A2SA 3MZ4A 4QA2A 5FUEA 5D1BA 5THUA 3EW8A 4BZ9A 3EZPA 3F07A 5DC5A 5IX0A 5G0GA 4RN1A 5G0JA 4QA1A 5DC8A 4QA5A 5JI5A 5G0HA 1T64A 4LXZA 4ZUPA 5D1DA 4BKXB 3MAXA 4ZURA 5IWGA 5G3WA 3EZTA 4CQFA 3Q9BA 2VQMA 5LI3A 5G1AA 2V5WA 4A69A 5ICNB 4CBYA 5D1CA 4ZUOA 3SFHA 1C3PA 5G0XA 5G13A 4QA4A 1T67A 2VQWG 5G1CA 5G0YA
chains in the Genus database with same CATH superfamily

4Q3UA 1P8SA 4RN0A 5EFHA 4Q3SA 3THJA 1WOIA 5EEFA 4MXRA 2VQVA 4QA3A 5G11A 1C3RA 3Q9CA 1T69A 2V5XA 3C0YA 1C3SA 3C10A 4HWWA 5G1BA 5THVA 4RN2A 1T4PA 1XFKA 1P8RA 3C0ZA 4FCIA 5G10A 3E6VA 4IXUA 5THSA 4HXQA 1R1OA 3F0RA 3MZ6A 5RLAA 5EFGA 5EEMA 1WOHA 3E8QA 5THTA 4RHQA 5G0IA 4BZ8A 3F06A 3SJTA 2A0MA 4QA0A 2CEVA 2GH6A 3E6KA 4ZUNA 4GWCA 5EENA 3Q9EA 5G17A 2PHOA 4BZ7A 4HZEA 4IE2A 5G12A 4I06A 4RHIA 2VQOA 4QA6A 4ZUMA 1TBJA 1PQ3A 1ZZ0A 4RHLA 3CEVA 1TBLA 5EEKA 4BZ5A 3MZ3A 3ZNSA 4ZUQA 1T5GA 5HJ9A 1RLAA 3RQDA 3LHLA 4Q3QA 4Q40A 3SL1A 3THEA 5EFNA 3NIQA 3ZNRA 2ZAVA 4GWDA 4CBTA 1VKGA 3SFFA 4BZ6A 4QA7A 5EF7A 3GN0A 4GSZA 5BWZA 1ZZ1A 1T5FA 3MMRA 3TF3A 3MZ7A 4Q3RC 5FCWA 4ITYA 4Q3PA 5DC6A 5EEIA 5EFKB 2EF4A 3MENA 3NIOA 3Q9FA 5EFJD 4IU5A 3DJ8A 2VQJA 4Q3VA 1W22A 3EWFA 1TA1A 4RHMA 5DC7A 5EF8A 2VQQA 2VCGA 4IU1A 4LY1A 4RLAA 4IU0A 4CEVA 1ZZ3A 3MFWA 5EFBD 5A2SA 1WOGA 4MYNA 3MZ4A 4QA2A 4RHJA 1P8NA 2PLLA 4FCKA 5FUEA 4IE3A 5D1BA 1HQHA 1HQFA 4GSVA 3THHA 2EIVA 5THUA 3NIPA 5CEVA 1HQ5A 1T4TA 3EW8A 4BZ9A 4Q42A 3LP7A 3EZPA 4MYFA 3F07A 5DC5A 3TH7A 5IX0A 1GQ6A 1WVAA 1HQXA 1T4RA 5G0GA 4RN1A 5G0JA 4QA1A 1TBHA 1T4SA 1ZPGA 4MYLA 5DC8A 5HJAA 1GQ7A 4GSMA 4QA5A 5JI5A 5G0HA 4Q3TA 4Q41A 4DZ4A 1T64A 4IU4A 1CEVA 3SKKA 3PZLA 2EF5A 4LXZA 4ZUPA 4G3HA 5D1DA 3RLAA 1ZPEA 4BKXB 3MAXA 4IE1A 4ZURA 5IWGA 5G3WA 4Q3RA 3EZTA 4CQFA 3E9BA 3Q9BA 1P8PA 2PHAA 3E8ZA 2VQMA 3KV2A 2AEBA 5LI3A 4MYKA 5G1AA 2V5WA 4A69A 5ICNB 1WVBA 3LP4A 3M1RA 4IXVA 3GMZA 4CBYA 5D1CA 1D3VA 4RHKA 4ZUOA 3MFVA 3MJLA 1HQGA 3SFHA 1P8QA 1C3PA 2RLAA 5G0XA 5G13A 4QA4A 1T67A 1P8OA 1P8MA 3F80A 3SL0A 2VQWG 5G1CA 5G0YA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 4RN0 A;  5EFH A;  5EEF A;  2VQV A;  4QA3 A;  5G11 A;  1C3R A;  3Q9C A;  1T69 A;  2V5X A;  3C0Y A;  1C3S A;  3C10 A;  5G1B A;  5THV A;  4RN2 A;  3C0Z A;  5G10 A;  5THS A;  3F0R A;  3MZ6 A;  5EFG A;  5EEM A;  5THT A;  5G0I A;  4BZ8 A;  3F06 A;  4QA0 A;  2GH6 A;  4ZUN A;  5EEN A;  3Q9E A;  5G17 A;  4BZ7 A;  5G12 A;  4ZUM A;  2VQO A;  4QA6 A;  1ZZ0 A;  5EEK A;  4BZ5 A;  4ZUQ A;  3MZ3 A;  3ZNS A;  3RQD A;  3ZNR A;  5EFN A;  4CBT A;  1VKG A;  3SFF A;  4BZ6 A;  4QA7 A;  5EF7 A;  5BWZ A;  1ZZ1 A;  3MZ7 A;  5FCW A;  5EEI A;  5DC6 A;  5EFK B;  3Q9F A;  3MEN A;  5EFJ D;  2VQJ A;  1W22 A;  3EWF A;  5DC7 A;  5EF8 A;  2VQQ A;  2VCG A;  4LY1 A;  1ZZ3 A;  5EFB D;  5A2S A;  3MZ4 A;  4QA2 A;  5FUE A;  5D1B A;  5THU A;  3EW8 A;  4BZ9 A;  3EZP A;  3F07 A;  5DC5 A;  5IX0 A;  5G0G A;  4RN1 A;  5G0J A;  4QA1 A;  5DC8 A;  4QA5 A;  5JI5 A;  5G0H A;  1T64 A;  4LXZ A;  4ZUP A;  5D1D A;  4BKX B;  3MAX A;  4ZUR A;  5IWG A;  5G3W A;  3EZT A;  4CQF A;  3Q9B A;  2VQM A;  5LI3 A;  5G1A A;  2V5W A;  4A69 A;  5ICN B;  4CBY A;  5D1C A;  4ZUO A;  3SFH A;  1C3P A;  5G0X A;  5G13 A;  4QA4 A;  1T67 A;  2VQW G;  5G1C A;  5G0Y A; 
#chains in the Genus database with same CATH topology
 4Q3U A;  1P8S A;  4RN0 A;  5EFH A;  4Q3S A;  3THJ A;  1WOI A;  5EEF A;  4MXR A;  2VQV A;  4QA3 A;  5G11 A;  1C3R A;  3Q9C A;  1T69 A;  2V5X A;  3C0Y A;  1C3S A;  3C10 A;  4HWW A;  5G1B A;  5THV A;  4RN2 A;  1T4P A;  1XFK A;  1P8R A;  3C0Z A;  4FCI A;  5G10 A;  3E6V A;  4IXU A;  5THS A;  4HXQ A;  1R1O A;  3F0R A;  3MZ6 A;  5RLA A;  5EFG A;  5EEM A;  1WOH A;  3E8Q A;  5THT A;  4RHQ A;  5G0I A;  4BZ8 A;  3F06 A;  3SJT A;  2A0M A;  4QA0 A;  2CEV A;  2GH6 A;  3E6K A;  4ZUN A;  4GWC A;  5EEN A;  3Q9E A;  5G17 A;  2PHO A;  4BZ7 A;  4HZE A;  4IE2 A;  5G12 A;  4I06 A;  4RHI A;  2VQO A;  4QA6 A;  4ZUM A;  1TBJ A;  1PQ3 A;  1ZZ0 A;  4RHL A;  3CEV A;  1TBL A;  5EEK A;  4BZ5 A;  3MZ3 A;  3ZNS A;  4ZUQ A;  1T5G A;  5HJ9 A;  1RLA A;  3RQD A;  3LHL A;  4Q3Q A;  4Q40 A;  3SL1 A;  3THE A;  5EFN A;  3NIQ A;  3ZNR A;  2ZAV A;  4GWD A;  4CBT A;  1VKG A;  3SFF A;  4BZ6 A;  4QA7 A;  5EF7 A;  3GN0 A;  4GSZ A;  5BWZ A;  1ZZ1 A;  1T5F A;  3MMR A;  3TF3 A;  3MZ7 A;  4Q3R C;  5FCW A;  4ITY A;  4Q3P A;  5DC6 A;  5EEI A;  5EFK B;  2EF4 A;  3MEN A;  3NIO A;  3Q9F A;  5EFJ D;  4IU5 A;  3DJ8 A;  2VQJ A;  4Q3V A;  1W22 A;  3EWF A;  1TA1 A;  4RHM A;  5DC7 A;  5EF8 A;  2VQQ A;  2VCG A;  4IU1 A;  4LY1 A;  4RLA A;  4IU0 A;  4CEV A;  1ZZ3 A;  3MFW A;  5EFB D;  5A2S A;  1WOG A;  4MYN A;  3MZ4 A;  4QA2 A;  4RHJ A;  1P8N A;  2PLL A;  4FCK A;  5FUE A;  4IE3 A;  5D1B A;  1HQH A;  1HQF A;  4GSV A;  3THH A;  2EIV A;  5THU A;  3NIP A;  5CEV A;  1HQ5 A;  1T4T A;  3EW8 A;  4BZ9 A;  4Q42 A;  3LP7 A;  3EZP A;  4MYF A;  3F07 A;  5DC5 A;  3TH7 A;  5IX0 A;  1GQ6 A;  1WVA A;  1HQX A;  1T4R A;  5G0G A;  4RN1 A;  5G0J A;  4QA1 A;  1TBH A;  1T4S A;  1ZPG A;  4MYL A;  5DC8 A;  5HJA A;  1GQ7 A;  4GSM A;  4QA5 A;  5JI5 A;  5G0H A;  4Q3T A;  4Q41 A;  4DZ4 A;  1T64 A;  4IU4 A;  1CEV A;  3SKK A;  3PZL A;  2EF5 A;  4LXZ A;  4ZUP A;  4G3H A;  5D1D A;  3RLA A;  1ZPE A;  4BKX B;  3MAX A;  4IE1 A;  4ZUR A;  5IWG A;  5G3W A;  4Q3R A;  3EZT A;  4CQF A;  3E9B A;  3Q9B A;  1P8P A;  2PHA A;  3E8Z A;  2VQM A;  3KV2 A;  2AEB A;  5LI3 A;  4MYK A;  5G1A A;  2V5W A;  4A69 A;  5ICN B;  1WVB A;  3LP4 A;  3M1R A;  4IXV A;  3GMZ A;  4CBY A;  5D1C A;  1D3V A;  4RHK A;  4ZUO A;  3MFV A;  3MJL A;  1HQG A;  3SFH A;  1P8Q A;  1C3P A;  2RLA A;  5G0X A;  5G13 A;  4QA4 A;  1T67 A;  1P8O A;  1P8M A;  3F80 A;  3SL0 A;  2VQW G;  5G1C A;  5G0Y A; 
#chains in the Genus database with same CATH homology
 4RN0 A;  5EFH A;  5EEF A;  2VQV A;  4QA3 A;  5G11 A;  1C3R A;  3Q9C A;  1T69 A;  2V5X A;  3C0Y A;  1C3S A;  3C10 A;  5G1B A;  5THV A;  4RN2 A;  3C0Z A;  5G10 A;  5THS A;  3F0R A;  3MZ6 A;  5EFG A;  5EEM A;  5THT A;  5G0I A;  4BZ8 A;  3F06 A;  4QA0 A;  2GH6 A;  4ZUN A;  5EEN A;  3Q9E A;  5G17 A;  4BZ7 A;  5G12 A;  4ZUM A;  2VQO A;  4QA6 A;  1ZZ0 A;  5EEK A;  4BZ5 A;  4ZUQ A;  3MZ3 A;  3ZNS A;  3RQD A;  3ZNR A;  5EFN A;  4CBT A;  1VKG A;  3SFF A;  4BZ6 A;  4QA7 A;  5EF7 A;  5BWZ A;  1ZZ1 A;  3MZ7 A;  5FCW A;  5EEI A;  5DC6 A;  5EFK B;  3Q9F A;  3MEN A;  5EFJ D;  2VQJ A;  1W22 A;  3EWF A;  5DC7 A;  5EF8 A;  2VQQ A;  2VCG A;  4LY1 A;  1ZZ3 A;  5EFB D;  5A2S A;  3MZ4 A;  4QA2 A;  5FUE A;  5D1B A;  5THU A;  3EW8 A;  4BZ9 A;  3EZP A;  3F07 A;  5DC5 A;  5IX0 A;  5G0G A;  4RN1 A;  5G0J A;  4QA1 A;  5DC8 A;  4QA5 A;  5JI5 A;  5G0H A;  1T64 A;  4LXZ A;  4ZUP A;  5D1D A;  4BKX B;  3MAX A;  4ZUR A;  5IWG A;  5G3W A;  3EZT A;  4CQF A;  3Q9B A;  2VQM A;  5LI3 A;  5G1A A;  2V5W A;  4A69 A;  5ICN B;  4CBY A;  5D1C A;  4ZUO A;  3SFH A;  1C3P A;  5G0X A;  5G13 A;  4QA4 A;  1T67 A;  2VQW G;  5G1C A;  5G0Y A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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5THUA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations