5THVA

Crystal structure of g305a hdac8 in complex with m344
Total Genus 132

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
132
sequence length
362
structure length
349
Chain Sequence
VPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQDSIEYGLTEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGAYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHV
5010015020025030030025020015010050
020406080100120Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
AH1 (22-31)TII1 (34-37)TVIII1 (32-35)S8 (297-301)AH2 (37-48)3H2 (93-96)3H1 (50-53)TI1 (136-139)AH5 (108-128)S2 (55-57)EMPTYAH4 (73-84)TI6 (266-269)TII2 (105-108)TIV5 (272-275)AH9 (281-293)TIV2 (149-152)AH6 (157-166)TIV1 (131-134)TI2 (141-144)TIV3 (166-169)TII5 (232-235)TI3 (145-148)TVIII3 (169-172)TI'1 (150-153)AH8 (237-255)TVIII2 (153-156)AH7 (183-189)S4 (172-176)S5 (195-202)TI4 (189-192)TIV4 (192-195)TII3 (204-207)3H3 (220-222)TI5 (213-216)TII4 (222-225)S6 (226-231)S7 (259-263)TII6 (269-272)3H4 (337-339)TI7 (334-337)TVIa2 (340-343)TI8 (341-344)AH3 (64-69)S3 (133-136)TVIa1 (207-210)AH10 (308-323)Updating...
connected with : NaN
molecule tags Hydrolase
source organism Homo sapiens
publication title Structural and Functional Influence of the Glycine-Rich Loop G302GGGY on the Catalytic Tyrosine of Histone Deacetylase 8.
pubmed doi rcsb
molecule keywords Histone deacetylase 8
total genus 132
structure length 349
sequence length 362
chains with identical sequence B
ec nomenclature ec 3.5.1.98: Histone deacetylase.
pdb deposition date 2016-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00850 Hist_deacetyl Histone deacetylase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.800.20 Alpha Beta 3-Layer(aba) Sandwich Arginase; Chain A Histone deacetylase domain 5thvA00
3RQDA 3Q9EA 3MZ4A 1W22A 3C0YA 2VQQA 5G0IA 5G1BA 4QA6A 3MAXA 5EFHA 2VQJA 3EZTA 3MENA 5D1BA 5G1CA 5EFJD 3SFHA 1T69A 2V5WA 5ICNB 2VQWG 4BZ7A 5EFKB 3Q9BA 3MZ7A 5D1CA 4LXZA 2VQOA 5THVA 3F0RA 1ZZ1A 5BWZA 4ZUNA 4BZ5A 3EW8A 4CQFA 5G0YA 4ZUMA 3ZNSA 3EZPA 5EFBD 4CBTA 4QA4A 1C3SA 5EEIA 5EFNA 1ZZ0A 5EEFA 1T67A 5EEMA 4ZURA 1T64A 5DC5A 5G0XA 5G3WA 4QA1A 5EF7A 5G12A 3Q9CA 4QA2A 2VCGA 4RN0A 3SFFA 4QA7A 5THUA 4LY1A 5THSA 4RN1A 3F06A 4CBYA 5EF8A 1ZZ3A 5D1DA 4BZ6A 2VQVA 2GH6A 4ZUPA 5G11A 5EENA 5IX0A 1VKGA 4BZ9A 1C3RA 4ZUOA 5G10A 5THTA 3MZ6A 3ZNRA 3Q9FA 3C10A 5EFGA 5IWGA 3C0ZA 5G0HA 5DC7A 5FCWA 5G13A 5EEKA 4QA0A 4BKXB 4QA5A 5G0JA 4ZUQA 5LI3A 5DC8A 4BZ8A 4RN2A 3MZ3A 5A2SA 5JI5A 5FUEA 2VQMA 4QA3A 5DC6A 5G0GA 3EWFA 4A69A 5G17A 2V5XA 1C3PA 3F07A 5G1AA
chains in the Genus database with same CATH superfamily
4IU1A 3RQDA 1T5GA 3Q9EA 1HQFA 4Q3RA 1TBLA 3MZ4A 4MYFA 1XFKA 1W22A 5CEVA 4MYLA 4RHIA 4RHJA 3C0YA 3F80A 4GSZA 3MFWA 1HQHA 2VQQA 4IE2A 3E8ZA 5G0IA 4CEVA 1P8PA 5G1BA 4QA6A 4Q3VA 3MAXA 5EFHA 2VQJA 4Q3SA 3SL1A 3CEVA 3EZTA 3MENA 1T4RA 4IU0A 5D1BA 1P8NA 5EFJD 5G1CA 4RHKA 3SFHA 1T69A 1D3VA 3SJTA 2RLAA 2V5WA 1ZPEA 5ICNB 2VQWG 4BZ7A 5EFKB 4IU4A 3MZ7A 3Q9BA 3E8QA 4LXZA 2VQOA 1CEVA 5D1CA 4Q3RC 5THVA 4Q41A 2EIVA 1PQ3A 4IE1A 3F0RA 4GWCA 1ZZ1A 2AEBA 5BWZA 4ZUNA 5RLAA 4BZ5A 3EW8A 4CQFA 5G0YA 4ZUMA 4MXRA 3ZNSA 3EZPA 3E6VA 5EFBD 2EF5A 4CBTA 4QA4A 1HQGA 1C3SA 3MJLA 4GSVA 4IU5A 5EEIA 1ZZ0A 1WVAA 1T67A 3PZLA 4Q42A 1T64A 5DC5A 5EEFA 2EF4A 3NIPA 5EEMA 4ZURA 5G0XA 5G3WA 3MMRA 1WVBA 4QA1A 3GMZA 4Q3UA 3Q9CA 4RHQA 3KV2A 5EF7A 5G12A 4FCKA 2ZAVA 3TH7A 4QA2A 2VCGA 4RN0A 1P8OA 3SFFA 4QA7A 5THUA 4LY1A 4RHMA 5THSA 3LHLA 1WOGA 3MFVA 4ITYA 1P8MA 4RN1A 3F06A 4CBYA 3LP7A 4Q3PA 5EF8A 1ZZ3A 5D1DA 4BZ6A 2VQVA 1RLAA 2GH6A 3DJ8A 4HZEA 5EENA 4ZUPA 1VKGA 5G11A 3E6KA 4BZ9A 1C3RA 4ZUOA 5G10A 4G3HA 4GWDA 5THTA 3NIQA 3MZ6A 5HJ9A 3Q9FA 4FCIA 1TBJA 1P8RA 3C10A 4IXVA 5EFGA 3ZNRA 4GSMA 1P8SA 5IWGA 3TF3A 3THJA 4DZ4A 3C0ZA 1TA1A 3GN0A 4HXQA 1T4TA 4MYKA 5DC7A 5FCWA 4RHLA 5EEKA 5G0HA 5G13A 4QA0A 2PHAA 1T4SA 3LP4A 4BKXB 1GQ6A 4I06A 2PHOA 4Q3QA 4QA5A 5G0JA 4IXUA 4ZUQA 5LI3A 5DC8A 4BZ8A 3NIOA 5EFNA 1GQ7A 4RN2A 5IX0A 3MZ3A 1WOHA 5A2SA 3RLAA 1WOIA 4Q3TA 4HWWA 3THHA 5JI5A 5FUEA 2VQMA 4QA3A 1P8QA 2CEVA 3SL0A 3E9BA 5DC6A 1T4PA 4IE3A 5G0GA 3EWFA 1TBHA 2PLLA 1T5FA 4A69A 1R1OA 2A0MA 3M1RA 5G17A 4MYNA 3SKKA 5HJAA 2V5XA 1C3PA 3THEA 3F07A 1HQXA 4Q40A 5G1AA 1HQ5A 1ZPGA 4RLAA
chains in the Genus database with same CATH topology
3RQDA 3Q9EA 3MZ4A 1W22A 3C0YA 2VQQA 5G0IA 5G1BA 4QA6A 3MAXA 5EFHA 2VQJA 3EZTA 3MENA 5D1BA 5G1CA 5EFJD 3SFHA 1T69A 2V5WA 5ICNB 2VQWG 4BZ7A 5EFKB 3Q9BA 3MZ7A 5D1CA 4LXZA 2VQOA 5THVA 3F0RA 1ZZ1A 5BWZA 4ZUNA 4BZ5A 3EW8A 4CQFA 5G0YA 4ZUMA 3ZNSA 3EZPA 5EFBD 4CBTA 4QA4A 1C3SA 5EEIA 5EFNA 1ZZ0A 5EEFA 1T67A 5EEMA 4ZURA 1T64A 5DC5A 5G0XA 5G3WA 4QA1A 5EF7A 5G12A 3Q9CA 4QA2A 2VCGA 4RN0A 3SFFA 4QA7A 5THUA 4LY1A 5THSA 4RN1A 3F06A 4CBYA 5EF8A 1ZZ3A 5D1DA 4BZ6A 2VQVA 2GH6A 4ZUPA 5G11A 5EENA 5IX0A 1VKGA 4BZ9A 1C3RA 4ZUOA 5G10A 5THTA 3MZ6A 3ZNRA 3Q9FA 3C10A 5EFGA 5IWGA 3C0ZA 5G0HA 5DC7A 5FCWA 5G13A 5EEKA 4QA0A 4BKXB 4QA5A 5G0JA 4ZUQA 5LI3A 5DC8A 4BZ8A 4RN2A 3MZ3A 5A2SA 5JI5A 5FUEA 2VQMA 4QA3A 5DC6A 5G0GA 3EWFA 4A69A 5G17A 2V5XA 1C3PA 3F07A 5G1AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3RQD A;  3Q9E A;  3MZ4 A;  1W22 A;  3C0Y A;  2VQQ A;  5G0I A;  5G1B A;  4QA6 A;  3MAX A;  5EFH A;  2VQJ A;  3EZT A;  3MEN A;  5D1B A;  5G1C A;  5EFJ D;  3SFH A;  1T69 A;  2V5W A;  5ICN B;  2VQW G;  4BZ7 A;  5EFK B;  3Q9B A;  3MZ7 A;  5D1C A;  4LXZ A;  2VQO A;  5THV A;  3F0R A;  1ZZ1 A;  5BWZ A;  4ZUN A;  4BZ5 A;  3EW8 A;  4CQF A;  5G0Y A;  4ZUM A;  3ZNS A;  3EZP A;  5EFB D;  4CBT A;  4QA4 A;  1C3S A;  5EEI A;  5EFN A;  1ZZ0 A;  5EEF A;  1T67 A;  5EEM A;  4ZUR A;  1T64 A;  5DC5 A;  5G0X A;  5G3W A;  4QA1 A;  5EF7 A;  5G12 A;  3Q9C A;  4QA2 A;  2VCG A;  4RN0 A;  3SFF A;  4QA7 A;  5THU A;  4LY1 A;  5THS A;  4RN1 A;  3F06 A;  4CBY A;  5EF8 A;  1ZZ3 A;  5D1D A;  4BZ6 A;  2VQV A;  2GH6 A;  4ZUP A;  5G11 A;  5EEN A;  5IX0 A;  1VKG A;  4BZ9 A;  1C3R A;  4ZUO A;  5G10 A;  5THT A;  3MZ6 A;  3ZNR A;  3Q9F A;  3C10 A;  5EFG A;  5IWG A;  3C0Z A;  5G0H A;  5DC7 A;  5FCW A;  5G13 A;  5EEK A;  4QA0 A;  4BKX B;  4QA5 A;  5G0J A;  4ZUQ A;  5LI3 A;  5DC8 A;  4BZ8 A;  4RN2 A;  3MZ3 A;  5A2S A;  5JI5 A;  5FUE A;  2VQM A;  4QA3 A;  5DC6 A;  5G0G A;  3EWF A;  4A69 A;  5G17 A;  2V5X A;  1C3P A;  3F07 A;  5G1A A; 
#chains in the Genus database with same CATH topology
 4IU1 A;  3RQD A;  1T5G A;  3Q9E A;  1HQF A;  4Q3R A;  1TBL A;  3MZ4 A;  4MYF A;  1XFK A;  1W22 A;  5CEV A;  4MYL A;  4RHI A;  4RHJ A;  3C0Y A;  3F80 A;  4GSZ A;  3MFW A;  1HQH A;  2VQQ A;  4IE2 A;  3E8Z A;  5G0I A;  4CEV A;  1P8P A;  5G1B A;  4QA6 A;  4Q3V A;  3MAX A;  5EFH A;  2VQJ A;  4Q3S A;  3SL1 A;  3CEV A;  3EZT A;  3MEN A;  1T4R A;  4IU0 A;  5D1B A;  1P8N A;  5EFJ D;  5G1C A;  4RHK A;  3SFH A;  1T69 A;  1D3V A;  3SJT A;  2RLA A;  2V5W A;  1ZPE A;  5ICN B;  2VQW G;  4BZ7 A;  5EFK B;  4IU4 A;  3MZ7 A;  3Q9B A;  3E8Q A;  4LXZ A;  2VQO A;  1CEV A;  5D1C A;  4Q3R C;  5THV A;  4Q41 A;  2EIV A;  1PQ3 A;  4IE1 A;  3F0R A;  4GWC A;  1ZZ1 A;  2AEB A;  5BWZ A;  4ZUN A;  5RLA A;  4BZ5 A;  3EW8 A;  4CQF A;  5G0Y A;  4ZUM A;  4MXR A;  3ZNS A;  3EZP A;  3E6V A;  5EFB D;  2EF5 A;  4CBT A;  4QA4 A;  1HQG A;  1C3S A;  3MJL A;  4GSV A;  4IU5 A;  5EEI A;  1ZZ0 A;  1WVA A;  1T67 A;  3PZL A;  4Q42 A;  1T64 A;  5DC5 A;  5EEF A;  2EF4 A;  3NIP A;  5EEM A;  4ZUR A;  5G0X A;  5G3W A;  3MMR A;  1WVB A;  4QA1 A;  3GMZ A;  4Q3U A;  3Q9C A;  4RHQ A;  3KV2 A;  5EF7 A;  5G12 A;  4FCK A;  2ZAV A;  3TH7 A;  4QA2 A;  2VCG A;  4RN0 A;  1P8O A;  3SFF A;  4QA7 A;  5THU A;  4LY1 A;  4RHM A;  5THS A;  3LHL A;  1WOG A;  3MFV A;  4ITY A;  1P8M A;  4RN1 A;  3F06 A;  4CBY A;  3LP7 A;  4Q3P A;  5EF8 A;  1ZZ3 A;  5D1D A;  4BZ6 A;  2VQV A;  1RLA A;  2GH6 A;  3DJ8 A;  4HZE A;  5EEN A;  4ZUP A;  1VKG A;  5G11 A;  3E6K A;  4BZ9 A;  1C3R A;  4ZUO A;  5G10 A;  4G3H A;  4GWD A;  5THT A;  3NIQ A;  3MZ6 A;  5HJ9 A;  3Q9F A;  4FCI A;  1TBJ A;  1P8R A;  3C10 A;  4IXV A;  5EFG A;  3ZNR A;  4GSM A;  1P8S A;  5IWG A;  3TF3 A;  3THJ A;  4DZ4 A;  3C0Z A;  1TA1 A;  3GN0 A;  4HXQ A;  1T4T A;  4MYK A;  5DC7 A;  5FCW A;  4RHL A;  5EEK A;  5G0H A;  5G13 A;  4QA0 A;  2PHA A;  1T4S A;  3LP4 A;  4BKX B;  1GQ6 A;  4I06 A;  2PHO A;  4Q3Q A;  4QA5 A;  5G0J A;  4IXU A;  4ZUQ A;  5LI3 A;  5DC8 A;  4BZ8 A;  3NIO A;  5EFN A;  1GQ7 A;  4RN2 A;  5IX0 A;  3MZ3 A;  1WOH A;  5A2S A;  3RLA A;  1WOI A;  4Q3T A;  4HWW A;  3THH A;  5JI5 A;  5FUE A;  2VQM A;  4QA3 A;  1P8Q A;  2CEV A;  3SL0 A;  3E9B A;  5DC6 A;  1T4P A;  4IE3 A;  5G0G A;  3EWF A;  1TBH A;  2PLL A;  1T5F A;  4A69 A;  1R1O A;  2A0M A;  3M1R A;  5G17 A;  4MYN A;  3SKK A;  5HJA A;  2V5X A;  1C3P A;  3THE A;  3F07 A;  1HQX A;  4Q40 A;  5G1A A;  1HQ5 A;  1ZPG A;  4RLA A; 
#chains in the Genus database with same CATH homology
 3RQD A;  3Q9E A;  3MZ4 A;  1W22 A;  3C0Y A;  2VQQ A;  5G0I A;  5G1B A;  4QA6 A;  3MAX A;  5EFH A;  2VQJ A;  3EZT A;  3MEN A;  5D1B A;  5G1C A;  5EFJ D;  3SFH A;  1T69 A;  2V5W A;  5ICN B;  2VQW G;  4BZ7 A;  5EFK B;  3Q9B A;  3MZ7 A;  5D1C A;  4LXZ A;  2VQO A;  5THV A;  3F0R A;  1ZZ1 A;  5BWZ A;  4ZUN A;  4BZ5 A;  3EW8 A;  4CQF A;  5G0Y A;  4ZUM A;  3ZNS A;  3EZP A;  5EFB D;  4CBT A;  4QA4 A;  1C3S A;  5EEI A;  5EFN A;  1ZZ0 A;  5EEF A;  1T67 A;  5EEM A;  4ZUR A;  1T64 A;  5DC5 A;  5G0X A;  5G3W A;  4QA1 A;  5EF7 A;  5G12 A;  3Q9C A;  4QA2 A;  2VCG A;  4RN0 A;  3SFF A;  4QA7 A;  5THU A;  4LY1 A;  5THS A;  4RN1 A;  3F06 A;  4CBY A;  5EF8 A;  1ZZ3 A;  5D1D A;  4BZ6 A;  2VQV A;  2GH6 A;  4ZUP A;  5G11 A;  5EEN A;  5IX0 A;  1VKG A;  4BZ9 A;  1C3R A;  4ZUO A;  5G10 A;  5THT A;  3MZ6 A;  3ZNR A;  3Q9F A;  3C10 A;  5EFG A;  5IWG A;  3C0Z A;  5G0H A;  5DC7 A;  5FCW A;  5G13 A;  5EEK A;  4QA0 A;  4BKX B;  4QA5 A;  5G0J A;  4ZUQ A;  5LI3 A;  5DC8 A;  4BZ8 A;  4RN2 A;  3MZ3 A;  5A2S A;  5JI5 A;  5FUE A;  2VQM A;  4QA3 A;  5DC6 A;  5G0G A;  3EWF A;  4A69 A;  5G17 A;  2V5X A;  1C3P A;  3F07 A;  5G1A A; 
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