1AZYA

Structural and theoretical studies suggest domain movement produces an active conformation of thymidine phosphorylase
Total Genus 145
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
145
sequence length
440
structure length
440
Chain Sequence
LFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENNWQEAAKAVKAAIKLADKAPESTPTVYRRISE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and theoretical studies suggest domain movement produces an active conformation of thymidine phosphorylase.
pubmed doi rcsb
molecule tags Glycosyltransferase
molecule keywords THYMIDINE PHOSPHORYLASE
total genus 145
structure length 440
sequence length 440
chains with identical sequence B
ec nomenclature ec 2.4.2.4: Thymidine phosphorylase.
pdb deposition date 1997-11-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
A PF07831 PYNP_C Pyrimidine nucleoside phosphorylase C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 1azyA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 1azyA02
3.90.1170.30 Alpha Beta Alpha-Beta Complex Aldehyde Oxidoreductase; domain 3 Pyrimidine nucleoside phosphorylase-like, C-terminal domain 1azyA03
4EAFA 2GVQA 5C2LA 1O17A 5BO3A 1ZYKA 4ZOKA 1BRWA 4GIUA 3R88A 3QS8A 2DSJA 1KGZA 4OWNA 4OWUA 1VQUA 5BYTA 2BPQA 4IJ1A 4X5DA 5C7SA 4GA4A 4YI7A 4ZOJA 4HKMA 4X46A 2WK6A 4X5EA 3R6CA 4EADA 1OTPA 2J0FA 4LHMA 5EP8A 4GA6A 4ZOFA 4X5BA 3H5QA 5C1RA 5EY3A 4OWSA 4X5CA 1KHDA 4ZTVA 1ZXYA 4N8QA 3TWPA 3QQSA 1UOUA 2WK5A 5BO2A 4OWQA 1ZVWA 4OWOA 1AZYA 4GKMA 4XR5A 3GBRA 4N5VA 4X5AA 5BNEA 4M0RA 4MUOA 4X58A 4OWVA 2TPTA 3QR9A 2ELCA 4GTNA 4OWMA 1V8GA 4N93A 4X59A 4YYYA 3UU1A 3QSAA 1GXBA 4YEKA 4GA5A
chains in the Genus database with same CATH superfamily
4EAFA 3B9JC 1VQ8H 2B7QA 3G4SH 3CCJH 2GVQA 1VQ5H 5AYZA 3RPFA 3G71H 5C2LA 3AM9A 3CCVH 1O17A 1M1KJ 1RRZA 1VQ7H 5BO3A 1ZYKA 1VQOH 4ZOKA 2W54B 4C7ZA 3CPWH 1BRWA 4GIUA 3NS1C 3R88A 3QS8A 3NVZC 1N60B 3J7ZM 1YHQH 1Q81J 1O4UA 1VQPH 1VQKH 3CCUH 1RM6A 2OTJH 4WFNJ 1NVIE 2DSJA 1JROB 5HUOA 3FAHA 3WO0A 1YJWH 1Q82J 1KGZA 1WYGA 4OWNA 3I56H 4WCEJ 1NVJA 4OWUA 1K8AJ 5GAHN 1QVFH 3CMAH 1N5XA 2JBMA 3CD6H 1VQUA 1FM0E 1K73J 5BYTA 4U67J 3CC2H 3PAJA 3CCMH 2W3SB 1YIJH 2BPQA 5GADN 3C2EA 4USAA 5MPOC 4IJ1A 3PIOJ 4X5DA 1DGJA 5C7SA 1X1OA 3SR6C 4GA4A 4YI7A 1FO4A 4ZOJA 4HKMA 1FFUB 1FMAE 3L4PA 4IOAJ 5GAEN 1M90J 2ZJPJ 4X46A 2WK6A 4UY8M 1KD1J 4X5EA 5DM7J 5JVGJ 1Q7YJ 2WP4A 4US9A 1VQLH 5HULA 4IOCJ 3ETRC 3C2RA 3R6CA 2ZJQJ 4EADA 1QPOA 1OTPA 1N61B 1VQNH 2J0FA 1YTEA 4LHMA 1YJ9H 5H1SO 5EP8A 4GA6A 3NVYC 1NJIJ 2ZJRJ 4ZOFA 4X5BA 5AYXA 3H5QA 1Q86J 3EUB4 5HL7J 5C1RA 5EY3A 4OWSA 3TQVA 3CCEH 4X5CA 3CXCH 2I1OA 1KQSH 2W55B 1KHDA 4ZTVA 1VQMH 4IO9J 4KWWA 1ZXYA 2I14A 4F3FC 3FC4A 4N8QA 3TWPA 1Y69K 3QQSA 1UOUA 4AP8A 5HUPA 3AN1A 2WK5A 2W3RB 1VLBA 5BO2A 4OWQA 4WFBJ 1ZVWA 3C2VA 3WO1A 1VQ6H 1YTDA 3C2OA 3DLLJ 2B7PA 4OWOA 2QEXH 1QVGH 1YJNH 1AZYA 4GKMA 2Q5WE 4KWVA 2OTLH 4XR5A 3GBRA 1JRPB 1QPQA 4C7YA 3G6EH 3CF5J 5JVHJ 4N5VA 3OW2H 3CCRH 1YTKA 1RF8B 4X5AA 5BNEA 1VQ9H 3CMEH 4M0RA 4MUOA 4X58A 3AMZA 4OWVA 1QPRA 1FIQC 1SB3A 1V97A 1N5WB 1QAPA 5GAGN 4WFAJ 1W2BH 1VDVA 4US8A 3C2FA 3GNNA 2TPTA 3QR9A 1ZXIB 1SIJA 3L0GA 3WNZA 2ELCA 4GTNA 5AYYA 2PA2A 1KC8J 3CC7H 3NVWC 4OWMA 1V8GA 1N8RJ 3I55H 5MLCO 4N93A 3CCSH 3NVVC 3PIPJ 3BIIE 4C80A 5AN9F 1N63B 5DM6J 4X59A 1YITH 1JJ2H 2QIEA 1N62B 1VQ4H 2E3TA 4I9AA 2QA4H 1S72H 1K9MJ 4YYYA 4WF9J 1YI2H 2B7NA 1WKIA 2OMDA 3NRZC 1FFVB 3UU1A 3QSAA 1QPNA 1GXBA 3VMMA 4YEKA 3CCQH 4ZOHA 3CCLH 3CC4H 4GA5A
chains in the Genus database with same CATH topology
4EAFA 2GVQA 5C2LA 1O17A 5BO3A 1ZYKA 4ZOKA 1BRWA 4GIUA 3R88A 3QS8A 2DSJA 1KGZA 4OWNA 4OWUA 1VQUA 5BYTA 2BPQA 4IJ1A 4X5DA 5C7SA 4GA4A 4YI7A 4ZOJA 4HKMA 4X46A 2WK6A 4X5EA 3R6CA 4EADA 1OTPA 2J0FA 4LHMA 5EP8A 4GA6A 4ZOFA 4X5BA 3H5QA 5C1RA 5EY3A 4OWSA 4X5CA 1KHDA 4ZTVA 1ZXYA 4N8QA 3TWPA 3QQSA 1UOUA 2WK5A 5BO2A 4OWQA 1ZVWA 4OWOA 1AZYA 4GKMA 4XR5A 3GBRA 4N5VA 4X5AA 5BNEA 4M0RA 4MUOA 4X58A 4OWVA 2TPTA 3QR9A 2ELCA 4GTNA 4OWMA 1V8GA 4N93A 4X59A 4YYYA 3UU1A 3QSAA 1GXBA 4YEKA 4GA5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EAF A;  2GVQ A;  5C2L A;  1O17 A;  5BO3 A;  1ZYK A;  4ZOK A;  1BRW A;  4GIU A;  3R88 A;  3QS8 A;  2DSJ A;  1KGZ A;  4OWN A;  4OWU A;  1VQU A;  5BYT A;  2BPQ A;  4IJ1 A;  4X5D A;  5C7S A;  4GA4 A;  4YI7 A;  4ZOJ A;  4HKM A;  4X46 A;  2WK6 A;  4X5E A;  3R6C A;  4EAD A;  1OTP A;  2J0F A;  4LHM A;  5EP8 A;  4GA6 A;  4ZOF A;  4X5B A;  3H5Q A;  5C1R A;  5EY3 A;  4OWS A;  4X5C A;  1KHD A;  4ZTV A;  1ZXY A;  4N8Q A;  3TWP A;  3QQS A;  1UOU A;  2WK5 A;  5BO2 A;  4OWQ A;  1ZVW A;  4OWO A;  1AZY A;  4GKM A;  4XR5 A;  3GBR A;  4N5V A;  4X5A A;  5BNE A;  4M0R A;  4MUO A;  4X58 A;  4OWV A;  2TPT A;  3QR9 A;  2ELC A;  4GTN A;  4OWM A;  1V8G A;  4N93 A;  4X59 A;  4YYY A;  3UU1 A;  3QSA A;  1GXB A;  4YEK A;  4GA5 A; 
#chains in the Genus database with same CATH topology
 4EAF A;  3B9J C;  1VQ8 H;  2B7Q A;  3G4S H;  3CCJ H;  2GVQ A;  1VQ5 H;  5AYZ A;  3RPF A;  3G71 H;  5C2L A;  3AM9 A;  3CCV H;  1O17 A;  1M1K J;  1RRZ A;  1VQ7 H;  5BO3 A;  1ZYK A;  1VQO H;  4ZOK A;  2W54 B;  4C7Z A;  3CPW H;  1BRW A;  4GIU A;  3NS1 C;  3R88 A;  3QS8 A;  3NVZ C;  1N60 B;  3J7Z M;  1YHQ H;  1Q81 J;  1O4U A;  1VQP H;  1VQK H;  3CCU H;  1RM6 A;  2OTJ H;  4WFN J;  1NVI E;  2DSJ A;  1JRO B;  5HUO A;  3FAH A;  3WO0 A;  1YJW H;  1Q82 J;  1KGZ A;  1WYG A;  4OWN A;  3I56 H;  4WCE J;  1NVJ A;  4OWU A;  1K8A J;  5GAH N;  1QVF H;  3CMA H;  1N5X A;  2JBM A;  3CD6 H;  1VQU A;  1FM0 E;  1K73 J;  5BYT A;  4U67 J;  3CC2 H;  3PAJ A;  3CCM H;  2W3S B;  1YIJ H;  2BPQ A;  5GAD N;  3C2E A;  4USA A;  5MPO C;  4IJ1 A;  3PIO J;  4X5D A;  1DGJ A;  5C7S A;  1X1O A;  3SR6 C;  4GA4 A;  4YI7 A;  1FO4 A;  4ZOJ A;  4HKM A;  1FFU B;  1FMA E;  3L4P A;  4IOA J;  5GAE N;  1M90 J;  2ZJP J;  4X46 A;  2WK6 A;  4UY8 M;  1KD1 J;  4X5E A;  5DM7 J;  5JVG J;  1Q7Y J;  2WP4 A;  4US9 A;  1VQL H;  5HUL A;  4IOC J;  3ETR C;  3C2R A;  3R6C A;  2ZJQ J;  4EAD A;  1QPO A;  1OTP A;  1N61 B;  1VQN H;  2J0F A;  1YTE A;  4LHM A;  1YJ9 H;  5H1S O;  5EP8 A;  4GA6 A;  3NVY C;  1NJI J;  2ZJR J;  4ZOF A;  4X5B A;  5AYX A;  3H5Q A;  1Q86 J;  3EUB 4;  5HL7 J;  5C1R A;  5EY3 A;  4OWS A;  3TQV A;  3CCE H;  4X5C A;  3CXC H;  2I1O A;  1KQS H;  2W55 B;  1KHD A;  4ZTV A;  1VQM H;  4IO9 J;  4KWW A;  1ZXY A;  2I14 A;  4F3F C;  3FC4 A;  4N8Q A;  3TWP A;  1Y69 K;  3QQS A;  1UOU A;  4AP8 A;  5HUP A;  3AN1 A;  2WK5 A;  2W3R B;  1VLB A;  5BO2 A;  4OWQ A;  4WFB J;  1ZVW A;  3C2V A;  3WO1 A;  1VQ6 H;  1YTD A;  3C2O A;  3DLL J;  2B7P A;  4OWO A;  2QEX H;  1QVG H;  1YJN H;  1AZY A;  4GKM A;  2Q5W E;  4KWV A;  2OTL H;  4XR5 A;  3GBR A;  1JRP B;  1QPQ A;  4C7Y A;  3G6E H;  3CF5 J;  5JVH J;  4N5V A;  3OW2 H;  3CCR H;  1YTK A;  1RF8 B;  4X5A A;  5BNE A;  1VQ9 H;  3CME H;  4M0R A;  4MUO A;  4X58 A;  3AMZ A;  4OWV A;  1QPR A;  1FIQ C;  1SB3 A;  1V97 A;  1N5W B;  1QAP A;  5GAG N;  4WFA J;  1W2B H;  1VDV A;  4US8 A;  3C2F A;  3GNN A;  2TPT A;  3QR9 A;  1ZXI B;  1SIJ A;  3L0G A;  3WNZ A;  2ELC A;  4GTN A;  5AYY A;  2PA2 A;  1KC8 J;  3CC7 H;  3NVW C;  4OWM A;  1V8G A;  1N8R J;  3I55 H;  5MLC O;  4N93 A;  3CCS H;  3NVV C;  3PIP J;  3BII E;  4C80 A;  5AN9 F;  1N63 B;  5DM6 J;  4X59 A;  1YIT H;  1JJ2 H;  2QIE A;  1N62 B;  1VQ4 H;  2E3T A;  4I9A A;  2QA4 H;  1S72 H;  1K9M J;  4YYY A;  4WF9 J;  1YI2 H;  2B7N A;  1WKI A;  2OMD A;  3NRZ C;  1FFV B;  3UU1 A;  3QSA A;  1QPN A;  1GXB A;  3VMM A;  4YEK A;  3CCQ H;  4ZOH A;  3CCL H;  3CC4 H;  4GA5 A; 
#chains in the Genus database with same CATH homology
 4EAF A;  2GVQ A;  5C2L A;  1O17 A;  5BO3 A;  1ZYK A;  4ZOK A;  1BRW A;  4GIU A;  3R88 A;  3QS8 A;  2DSJ A;  1KGZ A;  4OWN A;  4OWU A;  1VQU A;  5BYT A;  2BPQ A;  4IJ1 A;  4X5D A;  5C7S A;  4GA4 A;  4YI7 A;  4ZOJ A;  4HKM A;  4X46 A;  2WK6 A;  4X5E A;  3R6C A;  4EAD A;  1OTP A;  2J0F A;  4LHM A;  5EP8 A;  4GA6 A;  4ZOF A;  4X5B A;  3H5Q A;  5C1R A;  5EY3 A;  4OWS A;  4X5C A;  1KHD A;  4ZTV A;  1ZXY A;  4N8Q A;  3TWP A;  3QQS A;  1UOU A;  2WK5 A;  5BO2 A;  4OWQ A;  1ZVW A;  4OWO A;  1AZY A;  4GKM A;  4XR5 A;  3GBR A;  4N5V A;  4X5A A;  5BNE A;  4M0R A;  4MUO A;  4X58 A;  4OWV A;  2TPT A;  3QR9 A;  2ELC A;  4GTN A;  4OWM A;  1V8G A;  4N93 A;  4X59 A;  4YYY A;  3UU1 A;  3QSA A;  1GXB A;  4YEK A;  4GA5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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