1UOUA

Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
sequence length
446
structure length
438
Chain Sequence
PKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGALRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPLPFAELVLPP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Human Thymidine Phosphorylase in Complex with a Small Molecule Inhibitor
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords THYMIDINE PHOSPHORYLASE
total genus 159
structure length 438
sequence length 446
ec nomenclature ec 2.4.2.4: Thymidine phosphorylase.
pdb deposition date 2003-09-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
A PF07831 PYNP_C Pyrimidine nucleoside phosphorylase C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 1uouA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 1uouA02
3.90.1170.30 Alpha Beta Alpha-Beta Complex Aldehyde Oxidoreductase; domain 3 Pyrimidine nucleoside phosphorylase-like, C-terminal domain 1uouA03
4OWQA 4IJ1A 4GTNA 4OWMA 4ZOFA 5C2LA 4OWVA 3QR9A 4YI7A 4XR5A 2TPTA 1ZYKA 5BYTA 4OWSA 4OWNA 4N8QA 5BO2A 4X46A 4GA5A 3QQSA 2GVQA 5C7SA 4X58A 4X5CA 1KGZA 1OTPA 4EADA 4X5AA 5EP8A 4M0RA 2J0FA 2WK6A 4OWOA 2DSJA 5EY3A 4MUOA 3QSAA 4EAFA 4ZTVA 4ZOKA 3R88A 5BO3A 4N5VA 3QS8A 3UU1A 2WK5A 4YEKA 3TWPA 2ELCA 4OWUA 5C1RA 4X5DA 5BNEA 1GXBA 1BRWA 4X5BA 2BPQA 4HKMA 4N93A 3GBRA 1UOUA 4X59A 4LHMA 4GA6A 1VQUA 1ZVWA 4GKMA 1O17A 1ZXYA 4GIUA 3R6CA 1V8GA 3H5QA 1AZYA 4GA4A 1KHDA 4X5EA 4YYYA 4ZOJA
chains in the Genus database with same CATH superfamily
2ZJQJ 5JVHJ 4OWQA 4IJ1A 5HUOA 4GTNA 4OWMA 4ZOFA 5C2LA 1VLBA 2W54B 3AMZA 3ETRC 1Y69K 5GADN 4WF9J 1K9MJ 4OWVA 1YTKA 3CCEH 3QR9A 3SR6C 4YI7A 3CC4H 4XR5A 1ZYKA 2TPTA 5BYTA 3PIOJ 4AP8A 4OWSA 4OWNA 4N8QA 1Q81J 4GA5A 4X46A 5BO2A 3C2EA 3QQSA 2GVQA 3NRZC 4X5CA 4X58A 5C7SA 1KGZA 1OTPA 4EADA 2WP4A 1JRPB 1N62B 1RM6A 1YI2H 2I14A 3CMAH 2JBMA 1N5XA 2E3TA 3PAJA 4C7YA 3CXCH 3L0GA 4X5AA 3CCUH 1SIJA 1YJWH 4WCEJ 4UY8M 2B7NA 5EP8A 4M0RA 3L4PA 2J0FA 1WKIA 3NVYC 5HUPA 3TQVA 1FM0E 4USAA 2WK6A 3C2RA 1NJIJ 4OWOA 2Q5WE 1K73J 2DSJA 1FO4A 2QA4H 1QAPA 5EY3A 3NS1C 3RPFA 3PIPJ 4MUOA 3CCSH 1W2BH 3QSAA 4EAFA 1KC8J 4ZTVA 3WO1A 1NVIE 1DGJA 1QPRA 1VQLH 4IOAJ 1M1KJ 3CC7H 4I9AA 1RF8B 4ZOKA 3R88A 1Q86J 2ZJRJ 1FFVB 4WFBJ 5BO3A 3C2VA 2OTJH 5AYYA 1FMAE 1RRZA 4N5VA 1YJNH 3QS8A 3UU1A 1QPQA 2ZJPJ 1N63B 2W55B 3I56H 1Q7YJ 1VQ7H 3CCLH 3NVWC 3C2FA 5GAHN 2WK5A 1VDVA 4YEKA 4ZOHA 1VQOH 1M90J 3TWPA 4F3FC 5GAGN 1VQ9H 5H1SO 4C7ZA 1ZXIB 1YITH 2OTLH 5HULA 2ELCA 1YJ9H 5HL7J 1FIQC 1VQ6H 1YTDA 3CCRH 4OWUA 1N60B 3FAHA 4U67J 5C1RA 4X5DA 5BNEA 2W3SB 2W3RB 4US9A 1V97A 3CCVH 1YIJH 1FFUB 3FC4A 3AM9A 1SB3A 3G6EH 1O4UA 3CCQH 1VQ4H 1GXBA 4KWWA 3OW2H 1BRWA 1QPNA 4IO9J 1QVGH 3J7ZM 1VQNH 4X5BA 1K8AJ 1VQ5H 4C80A 3DLLJ 4US8A 2BPQA 4HKMA 1NVJA 5DM6J 5GAEN 4N93A 1QPOA 1X1OA 2OMDA 3GBRA 1UOUA 3G71H 1KD1J 5DM7J 2B7QA 4X59A 4LHMA 5AYXA 5MPOC 4GA6A 3CF5J 1N5WB 3G4SH 1YHQH 1WYGA 1S72H 1JJ2H 3VMMA 2QIEA 1N61B 1VQ8H 3EUB4 3CPWH 1VQUA 1ZVWA 4KWVA 3NVVC 3I55H 3BIIE 4GKMA 1Q82J 5AN9F 3WNZA 4WFAJ 1O17A 2PA2A 1JROB 1ZXYA 3CCJH 4GIUA 1YTEA 5AYZA 3R6CA 5MLCO 3CCMH 2B7PA 1V8GA 1VQKH 3AN1A 3CMEH 3C2OA 3H5QA 3B9JC 4IOCJ 1AZYA 4GA4A 3GNNA 3CD6H 1N8RJ 2QEXH 1QVFH 2I1OA 1VQPH 4WFNJ 1VQMH 1KQSH 3NVZC 5JVGJ 3CC2H 3WO0A 1KHDA 4X5EA 4YYYA 4ZOJA
chains in the Genus database with same CATH topology
4OWQA 4IJ1A 4GTNA 4OWMA 4ZOFA 5C2LA 4OWVA 3QR9A 4YI7A 4XR5A 2TPTA 1ZYKA 5BYTA 4OWSA 4OWNA 4N8QA 5BO2A 4X46A 4GA5A 3QQSA 2GVQA 5C7SA 4X58A 4X5CA 1KGZA 1OTPA 4EADA 4X5AA 5EP8A 4M0RA 2J0FA 2WK6A 4OWOA 2DSJA 5EY3A 4MUOA 3QSAA 4EAFA 4ZTVA 4ZOKA 3R88A 5BO3A 4N5VA 3QS8A 3UU1A 2WK5A 4YEKA 3TWPA 2ELCA 4OWUA 5C1RA 4X5DA 5BNEA 1GXBA 1BRWA 4X5BA 2BPQA 4HKMA 4N93A 3GBRA 1UOUA 4X59A 4LHMA 4GA6A 1VQUA 1ZVWA 4GKMA 1O17A 1ZXYA 4GIUA 3R6CA 1V8GA 3H5QA 1AZYA 4GA4A 1KHDA 4X5EA 4YYYA 4ZOJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OWQ A;  4IJ1 A;  4GTN A;  4OWM A;  4ZOF A;  5C2L A;  4OWV A;  3QR9 A;  4YI7 A;  4XR5 A;  2TPT A;  1ZYK A;  5BYT A;  4OWS A;  4OWN A;  4N8Q A;  5BO2 A;  4X46 A;  4GA5 A;  3QQS A;  2GVQ A;  5C7S A;  4X58 A;  4X5C A;  1KGZ A;  1OTP A;  4EAD A;  4X5A A;  5EP8 A;  4M0R A;  2J0F A;  2WK6 A;  4OWO A;  2DSJ A;  5EY3 A;  4MUO A;  3QSA A;  4EAF A;  4ZTV A;  4ZOK A;  3R88 A;  5BO3 A;  4N5V A;  3QS8 A;  3UU1 A;  2WK5 A;  4YEK A;  3TWP A;  2ELC A;  4OWU A;  5C1R A;  4X5D A;  5BNE A;  1GXB A;  1BRW A;  4X5B A;  2BPQ A;  4HKM A;  4N93 A;  3GBR A;  1UOU A;  4X59 A;  4LHM A;  4GA6 A;  1VQU A;  1ZVW A;  4GKM A;  1O17 A;  1ZXY A;  4GIU A;  3R6C A;  1V8G A;  3H5Q A;  1AZY A;  4GA4 A;  1KHD A;  4X5E A;  4YYY A;  4ZOJ A; 
#chains in the Genus database with same CATH topology
 2ZJQ J;  5JVH J;  4OWQ A;  4IJ1 A;  5HUO A;  4GTN A;  4OWM A;  4ZOF A;  5C2L A;  1VLB A;  2W54 B;  3AMZ A;  3ETR C;  1Y69 K;  5GAD N;  4WF9 J;  1K9M J;  4OWV A;  1YTK A;  3CCE H;  3QR9 A;  3SR6 C;  4YI7 A;  3CC4 H;  4XR5 A;  1ZYK A;  2TPT A;  5BYT A;  3PIO J;  4AP8 A;  4OWS A;  4OWN A;  4N8Q A;  1Q81 J;  4GA5 A;  4X46 A;  5BO2 A;  3C2E A;  3QQS A;  2GVQ A;  3NRZ C;  4X5C A;  4X58 A;  5C7S A;  1KGZ A;  1OTP A;  4EAD A;  2WP4 A;  1JRP B;  1N62 B;  1RM6 A;  1YI2 H;  2I14 A;  3CMA H;  2JBM A;  1N5X A;  2E3T A;  3PAJ A;  4C7Y A;  3CXC H;  3L0G A;  4X5A A;  3CCU H;  1SIJ A;  1YJW H;  4WCE J;  4UY8 M;  2B7N A;  5EP8 A;  4M0R A;  3L4P A;  2J0F A;  1WKI A;  3NVY C;  5HUP A;  3TQV A;  1FM0 E;  4USA A;  2WK6 A;  3C2R A;  1NJI J;  4OWO A;  2Q5W E;  1K73 J;  2DSJ A;  1FO4 A;  2QA4 H;  1QAP A;  5EY3 A;  3NS1 C;  3RPF A;  3PIP J;  4MUO A;  3CCS H;  1W2B H;  3QSA A;  4EAF A;  1KC8 J;  4ZTV A;  3WO1 A;  1NVI E;  1DGJ A;  1QPR A;  1VQL H;  4IOA J;  1M1K J;  3CC7 H;  4I9A A;  1RF8 B;  4ZOK A;  3R88 A;  1Q86 J;  2ZJR J;  1FFV B;  4WFB J;  5BO3 A;  3C2V A;  2OTJ H;  5AYY A;  1FMA E;  1RRZ A;  4N5V A;  1YJN H;  3QS8 A;  3UU1 A;  1QPQ A;  2ZJP J;  1N63 B;  2W55 B;  3I56 H;  1Q7Y J;  1VQ7 H;  3CCL H;  3NVW C;  3C2F A;  5GAH N;  2WK5 A;  1VDV A;  4YEK A;  4ZOH A;  1VQO H;  1M90 J;  3TWP A;  4F3F C;  5GAG N;  1VQ9 H;  5H1S O;  4C7Z A;  1ZXI B;  1YIT H;  2OTL H;  5HUL A;  2ELC A;  1YJ9 H;  5HL7 J;  1FIQ C;  1VQ6 H;  1YTD A;  3CCR H;  4OWU A;  1N60 B;  3FAH A;  4U67 J;  5C1R A;  4X5D A;  5BNE A;  2W3S B;  2W3R B;  4US9 A;  1V97 A;  3CCV H;  1YIJ H;  1FFU B;  3FC4 A;  3AM9 A;  1SB3 A;  3G6E H;  1O4U A;  3CCQ H;  1VQ4 H;  1GXB A;  4KWW A;  3OW2 H;  1BRW A;  1QPN A;  4IO9 J;  1QVG H;  3J7Z M;  1VQN H;  4X5B A;  1K8A J;  1VQ5 H;  4C80 A;  3DLL J;  4US8 A;  2BPQ A;  4HKM A;  1NVJ A;  5DM6 J;  5GAE N;  4N93 A;  1QPO A;  1X1O A;  2OMD A;  3GBR A;  1UOU A;  3G71 H;  1KD1 J;  5DM7 J;  2B7Q A;  4X59 A;  4LHM A;  5AYX A;  5MPO C;  4GA6 A;  3CF5 J;  1N5W B;  3G4S H;  1YHQ H;  1WYG A;  1S72 H;  1JJ2 H;  3VMM A;  2QIE A;  1N61 B;  1VQ8 H;  3EUB 4;  3CPW H;  1VQU A;  1ZVW A;  4KWV A;  3NVV C;  3I55 H;  3BII E;  4GKM A;  1Q82 J;  5AN9 F;  3WNZ A;  4WFA J;  1O17 A;  2PA2 A;  1JRO B;  1ZXY A;  3CCJ H;  4GIU A;  1YTE A;  5AYZ A;  3R6C A;  5MLC O;  3CCM H;  2B7P A;  1V8G A;  1VQK H;  3AN1 A;  3CME H;  3C2O A;  3H5Q A;  3B9J C;  4IOC J;  1AZY A;  4GA4 A;  3GNN A;  3CD6 H;  1N8R J;  2QEX H;  1QVF H;  2I1O A;  1VQP H;  4WFN J;  1VQM H;  1KQS H;  3NVZ C;  5JVG J;  3CC2 H;  3WO0 A;  1KHD A;  4X5E A;  4YYY A;  4ZOJ A; 
#chains in the Genus database with same CATH homology
 4OWQ A;  4IJ1 A;  4GTN A;  4OWM A;  4ZOF A;  5C2L A;  4OWV A;  3QR9 A;  4YI7 A;  4XR5 A;  2TPT A;  1ZYK A;  5BYT A;  4OWS A;  4OWN A;  4N8Q A;  5BO2 A;  4X46 A;  4GA5 A;  3QQS A;  2GVQ A;  5C7S A;  4X58 A;  4X5C A;  1KGZ A;  1OTP A;  4EAD A;  4X5A A;  5EP8 A;  4M0R A;  2J0F A;  2WK6 A;  4OWO A;  2DSJ A;  5EY3 A;  4MUO A;  3QSA A;  4EAF A;  4ZTV A;  4ZOK A;  3R88 A;  5BO3 A;  4N5V A;  3QS8 A;  3UU1 A;  2WK5 A;  4YEK A;  3TWP A;  2ELC A;  4OWU A;  5C1R A;  4X5D A;  5BNE A;  1GXB A;  1BRW A;  4X5B A;  2BPQ A;  4HKM A;  4N93 A;  3GBR A;  1UOU A;  4X59 A;  4LHM A;  4GA6 A;  1VQU A;  1ZVW A;  4GKM A;  1O17 A;  1ZXY A;  4GIU A;  3R6C A;  1V8G A;  3H5Q A;  1AZY A;  4GA4 A;  1KHD A;  4X5E A;  4YYY A;  4ZOJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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