1UOUA

Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor
Total Genus 159
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
sequence length
446
structure length
438
Chain Sequence
PKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGALRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPLPFAELVLPP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Crystal Structure of Human Thymidine Phosphorylase in Complex with a Small Molecule Inhibitor
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords THYMIDINE PHOSPHORYLASE
total genus 159
structure length 438
sequence length 446
ec nomenclature ec 2.4.2.4: Thymidine phosphorylase.
pdb deposition date 2003-09-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
A PF07831 PYNP_C Pyrimidine nucleoside phosphorylase C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 1uouA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 1uouA02
3.90.1170.30 Alpha Beta Alpha-Beta Complex Aldehyde Oxidoreductase; domain 3 Pyrimidine nucleoside phosphorylase-like, C-terminal domain 1uouA03
4ZOFA 1AZYA 4LHMA 3QQSA 4EADA 4OWSA 4X5BA 4GKMA 4IJ1A 1KHDA 4X5EA 1OTPA 2WK6A 4OWQA 4GIUA 4M0RA 4ZOKA 4N93A 4X58A 4GA5A 5EY3A 1GXBA 4N8QA 5BYTA 3TWPA 4X59A 2TPTA 1KGZA 1ZVWA 4X5AA 1V8GA 1BRWA 4X5CA 4GA6A 4OWOA 4ZOJA 3QSAA 4YI7A 2DSJA 4MUOA 4EAFA 3QR9A 5BO3A 2ELCA 3GBRA 4OWNA 4N5VA 2BPQA 1UOUA 4OWVA 2WK5A 5C7SA 4X5DA 1O17A 4GA4A 3R88A 4OWMA 4HKMA 2GVQA 2J0FA 5BNEA 4YEKA 3UU1A 4XR5A 3R6CA 5C1RA 4ZTVA 4YYYA 4X46A 5C2LA 4OWUA 5EP8A 5BO2A 1ZYKA 1VQUA 1ZXYA 3QS8A 3H5QA 4GTNA
chains in the Genus database with same CATH superfamily
4ZOFA 1SB3A 2QA4H 5AYXA 4WFAJ 1N5WB 5AN9F 1AZYA 4LHMA 3QQSA 4AP8A 1S72H 4EADA 5H1SO 1W2BH 4OWSA 3NVZC 5HUPA 3WO0A 4C7ZA 5GAGN 1FMAE 1YJ9H 5JVGJ 4X5BA 3OW2H 1Q7YJ 5GAEN 4KWVA 1VQ5H 1KC8J 4GKMA 1RM6A 3BIIE 1N5XA 2E3TA 4IJ1A 1QPQA 1YTEA 1KHDA 1QPNA 4USAA 4X5EA 3NVYC 3AMZA 3NVWC 1OTPA 2WK6A 3ETRC 1QVFH 2W3SB 4WFBJ 2QEXH 1YJNH 5HL7J 1N61B 2OMDA 3NS1C 1VDVA 2WP4A 5JVHJ 3FAHA 3SR6C 4OWQA 1NVIE 2W3RB 1YTDA 1M1KJ 2I1OA 1N60B 3FC4A 3CCEH 4GIUA 1VQMH 2I14A 1QPRA 4M0RA 1YJWH 4ZOKA 1FO4A 4N93A 4X58A 3CCSH 2W55B 4GA5A 1QVGH 5EY3A 1K9MJ 1VQ8H 1FFUB 1GXBA 4N8QA 5BYTA 3TWPA 3CC2H 1VLBA 3EUB4 4X59A 2TPTA 3PIOJ 1KGZA 1ZVWA 1N62B 4X5AA 1V8GA 1BRWA 2B7NA 1VQNH 1RF8B 3CMEH 3PAJA 1VQOH 1KD1J 1JRPB 1ZXIB 4X5CA 1QPOA 4IOCJ 4GA6A 1DGJA 1Y69K 4OWOA 2B7QA 4ZOJA 3J7ZM 4IOAJ 3QSAA 1Q82J 1NJIJ 2ZJRJ 1QAPA 4YI7A 2DSJA 3VMMA 5MLCO 1VQ9H 1VQ6H 4MUOA 4EAFA 4WCEJ 3CMAH 3QR9A 4UY8M 1YTKA 5BO3A 2ELCA 2B7PA 3CCMH 3GBRA 4OWNA 3AM9A 1VQLH 4N5VA 3CC4H 2BPQA 5AYZA 2OTLH 1UOUA 3CCUH 4OWVA 4I9AA 2WK5A 2PA2A 1FM0E 2JBMA 3CCQH 5C7SA 4X5DA 1K8AJ 3CC7H 1O17A 1N63B 4IO9J 4GA4A 3R88A 4WFNJ 1Q86J 3B9JC 3CXCH 4OWMA 1VQKH 1YI2H 3G71H 4HKMA 2OTJH 2GVQA 4ZOHA 2J0FA 4C80A 5BNEA 3TQVA 1JROB 4YEKA 1M90J 3C2RA 3GNNA 3WO1A 3C2VA 4US9A 5HUOA 3UU1A 1SIJA 2ZJPJ 3CF5J 1KQSH 4XR5A 4F3FC 3R6CA 3I56H 3CCRH 3CCVH 1WYGA 5C1RA 5HULA 5DM7J 3C2EA 4ZTVA 4YYYA 3NRZC 5MPOC 4X46A 3AN1A 5C2LA 1FIQC 4OWUA 2ZJQJ 1VQ7H 3RPFA 4WF9J 1N8RJ 5EP8A 1VQ4H 5BO2A 5GADN 3DLLJ 3L4PA 5AYYA 1YIJH 4KWWA 1ZYKA 3NVVC 3G4SH 1NVJA 3C2OA 3CPWH 2Q5WE 3PIPJ 3G6EH 1O4UA 1Q81J 1RRZA 4US8A 1VQUA 1K73J 1VQPH 1ZXYA 3L0GA 4C7YA 5DM6J 1JJ2H 1FFVB 3CD6H 2QIEA 3I55H 2W54B 3QS8A 3WNZA 1YITH 3C2FA 1WKIA 3CCLH 1YHQH 4U67J 3H5QA 4GTNA 1V97A 5GAHN 1X1OA 3CCJH
chains in the Genus database with same CATH topology
4ZOFA 1AZYA 4LHMA 3QQSA 4EADA 4OWSA 4X5BA 4GKMA 4IJ1A 1KHDA 4X5EA 1OTPA 2WK6A 4OWQA 4GIUA 4M0RA 4ZOKA 4N93A 4X58A 4GA5A 5EY3A 1GXBA 4N8QA 5BYTA 3TWPA 4X59A 2TPTA 1KGZA 1ZVWA 4X5AA 1V8GA 1BRWA 4X5CA 4GA6A 4OWOA 4ZOJA 3QSAA 4YI7A 2DSJA 4MUOA 4EAFA 3QR9A 5BO3A 2ELCA 3GBRA 4OWNA 4N5VA 2BPQA 1UOUA 4OWVA 2WK5A 5C7SA 4X5DA 1O17A 4GA4A 3R88A 4OWMA 4HKMA 2GVQA 2J0FA 5BNEA 4YEKA 3UU1A 4XR5A 3R6CA 5C1RA 4ZTVA 4YYYA 4X46A 5C2LA 4OWUA 5EP8A 5BO2A 1ZYKA 1VQUA 1ZXYA 3QS8A 3H5QA 4GTNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZOF A;  1AZY A;  4LHM A;  3QQS A;  4EAD A;  4OWS A;  4X5B A;  4GKM A;  4IJ1 A;  1KHD A;  4X5E A;  1OTP A;  2WK6 A;  4OWQ A;  4GIU A;  4M0R A;  4ZOK A;  4N93 A;  4X58 A;  4GA5 A;  5EY3 A;  1GXB A;  4N8Q A;  5BYT A;  3TWP A;  4X59 A;  2TPT A;  1KGZ A;  1ZVW A;  4X5A A;  1V8G A;  1BRW A;  4X5C A;  4GA6 A;  4OWO A;  4ZOJ A;  3QSA A;  4YI7 A;  2DSJ A;  4MUO A;  4EAF A;  3QR9 A;  5BO3 A;  2ELC A;  3GBR A;  4OWN A;  4N5V A;  2BPQ A;  1UOU A;  4OWV A;  2WK5 A;  5C7S A;  4X5D A;  1O17 A;  4GA4 A;  3R88 A;  4OWM A;  4HKM A;  2GVQ A;  2J0F A;  5BNE A;  4YEK A;  3UU1 A;  4XR5 A;  3R6C A;  5C1R A;  4ZTV A;  4YYY A;  4X46 A;  5C2L A;  4OWU A;  5EP8 A;  5BO2 A;  1ZYK A;  1VQU A;  1ZXY A;  3QS8 A;  3H5Q A;  4GTN A; 
#chains in the Genus database with same CATH topology
 4ZOF A;  1SB3 A;  2QA4 H;  5AYX A;  4WFA J;  1N5W B;  5AN9 F;  1AZY A;  4LHM A;  3QQS A;  4AP8 A;  1S72 H;  4EAD A;  5H1S O;  1W2B H;  4OWS A;  3NVZ C;  5HUP A;  3WO0 A;  4C7Z A;  5GAG N;  1FMA E;  1YJ9 H;  5JVG J;  4X5B A;  3OW2 H;  1Q7Y J;  5GAE N;  4KWV A;  1VQ5 H;  1KC8 J;  4GKM A;  1RM6 A;  3BII E;  1N5X A;  2E3T A;  4IJ1 A;  1QPQ A;  1YTE A;  1KHD A;  1QPN A;  4USA A;  4X5E A;  3NVY C;  3AMZ A;  3NVW C;  1OTP A;  2WK6 A;  3ETR C;  1QVF H;  2W3S B;  4WFB J;  2QEX H;  1YJN H;  5HL7 J;  1N61 B;  2OMD A;  3NS1 C;  1VDV A;  2WP4 A;  5JVH J;  3FAH A;  3SR6 C;  4OWQ A;  1NVI E;  2W3R B;  1YTD A;  1M1K J;  2I1O A;  1N60 B;  3FC4 A;  3CCE H;  4GIU A;  1VQM H;  2I14 A;  1QPR A;  4M0R A;  1YJW H;  4ZOK A;  1FO4 A;  4N93 A;  4X58 A;  3CCS H;  2W55 B;  4GA5 A;  1QVG H;  5EY3 A;  1K9M J;  1VQ8 H;  1FFU B;  1GXB A;  4N8Q A;  5BYT A;  3TWP A;  3CC2 H;  1VLB A;  3EUB 4;  4X59 A;  2TPT A;  3PIO J;  1KGZ A;  1ZVW A;  1N62 B;  4X5A A;  1V8G A;  1BRW A;  2B7N A;  1VQN H;  1RF8 B;  3CME H;  3PAJ A;  1VQO H;  1KD1 J;  1JRP B;  1ZXI B;  4X5C A;  1QPO A;  4IOC J;  4GA6 A;  1DGJ A;  1Y69 K;  4OWO A;  2B7Q A;  4ZOJ A;  3J7Z M;  4IOA J;  3QSA A;  1Q82 J;  1NJI J;  2ZJR J;  1QAP A;  4YI7 A;  2DSJ A;  3VMM A;  5MLC O;  1VQ9 H;  1VQ6 H;  4MUO A;  4EAF A;  4WCE J;  3CMA H;  3QR9 A;  4UY8 M;  1YTK A;  5BO3 A;  2ELC A;  2B7P A;  3CCM H;  3GBR A;  4OWN A;  3AM9 A;  1VQL H;  4N5V A;  3CC4 H;  2BPQ A;  5AYZ A;  2OTL H;  1UOU A;  3CCU H;  4OWV A;  4I9A A;  2WK5 A;  2PA2 A;  1FM0 E;  2JBM A;  3CCQ H;  5C7S A;  4X5D A;  1K8A J;  3CC7 H;  1O17 A;  1N63 B;  4IO9 J;  4GA4 A;  3R88 A;  4WFN J;  1Q86 J;  3B9J C;  3CXC H;  4OWM A;  1VQK H;  1YI2 H;  3G71 H;  4HKM A;  2OTJ H;  2GVQ A;  4ZOH A;  2J0F A;  4C80 A;  5BNE A;  3TQV A;  1JRO B;  4YEK A;  1M90 J;  3C2R A;  3GNN A;  3WO1 A;  3C2V A;  4US9 A;  5HUO A;  3UU1 A;  1SIJ A;  2ZJP J;  3CF5 J;  1KQS H;  4XR5 A;  4F3F C;  3R6C A;  3I56 H;  3CCR H;  3CCV H;  1WYG A;  5C1R A;  5HUL A;  5DM7 J;  3C2E A;  4ZTV A;  4YYY A;  3NRZ C;  5MPO C;  4X46 A;  3AN1 A;  5C2L A;  1FIQ C;  4OWU A;  2ZJQ J;  1VQ7 H;  3RPF A;  4WF9 J;  1N8R J;  5EP8 A;  1VQ4 H;  5BO2 A;  5GAD N;  3DLL J;  3L4P A;  5AYY A;  1YIJ H;  4KWW A;  1ZYK A;  3NVV C;  3G4S H;  1NVJ A;  3C2O A;  3CPW H;  2Q5W E;  3PIP J;  3G6E H;  1O4U A;  1Q81 J;  1RRZ A;  4US8 A;  1VQU A;  1K73 J;  1VQP H;  1ZXY A;  3L0G A;  4C7Y A;  5DM6 J;  1JJ2 H;  1FFV B;  3CD6 H;  2QIE A;  3I55 H;  2W54 B;  3QS8 A;  3WNZ A;  1YIT H;  3C2F A;  1WKI A;  3CCL H;  1YHQ H;  4U67 J;  3H5Q A;  4GTN A;  1V97 A;  5GAH N;  1X1O A;  3CCJ H; 
#chains in the Genus database with same CATH homology
 4ZOF A;  1AZY A;  4LHM A;  3QQS A;  4EAD A;  4OWS A;  4X5B A;  4GKM A;  4IJ1 A;  1KHD A;  4X5E A;  1OTP A;  2WK6 A;  4OWQ A;  4GIU A;  4M0R A;  4ZOK A;  4N93 A;  4X58 A;  4GA5 A;  5EY3 A;  1GXB A;  4N8Q A;  5BYT A;  3TWP A;  4X59 A;  2TPT A;  1KGZ A;  1ZVW A;  4X5A A;  1V8G A;  1BRW A;  4X5C A;  4GA6 A;  4OWO A;  4ZOJ A;  3QSA A;  4YI7 A;  2DSJ A;  4MUO A;  4EAF A;  3QR9 A;  5BO3 A;  2ELC A;  3GBR A;  4OWN A;  4N5V A;  2BPQ A;  1UOU A;  4OWV A;  2WK5 A;  5C7S A;  4X5D A;  1O17 A;  4GA4 A;  3R88 A;  4OWM A;  4HKM A;  2GVQ A;  2J0F A;  5BNE A;  4YEK A;  3UU1 A;  4XR5 A;  3R6C A;  5C1R A;  4ZTV A;  4YYY A;  4X46 A;  5C2L A;  4OWU A;  5EP8 A;  5BO2 A;  1ZYK A;  1VQU A;  1ZXY A;  3QS8 A;  3H5Q A;  4GTN A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...