2J0FA

Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implication for drug design
Total Genus 159
50100150200250300350400020406080100120140160
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
sequence length
446
structure length
446
Chain Sequence
KQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGAGAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPLPFAELVLP
50100150200250300350400400300200100
050100150Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYTVIII1 (64-67)TVIII2 (159-162)AH6 (154-159)AH3 (68-81)TIV2 (190-193)AH10 (245-262)AH4 (85-97)3H1 (106-108)TI1 (108-111)TII'1 (148-151)TI3 (188-191)TI2 (109-112)TII1 (120-123)AH5 (124-136)S1 (113-117)AH7 (170-180)TIV3 (203-206)AH12 (300-317)S2 (140-143)TII2 (161-164)S3 (182-185)AH8 (193-203)AH9 (211-225)S4 (229-235)TVIII3 (227-230)AH15 (354-362)TVIII4 (240-243)S5 (266-272)AH13 (323-336)AH14 (338-350)AH16 (365-371)TI4 (416-419)S7 (377-383)S8 (387-392)AH17 (394-404)TII5 (432-435)S10 (429-431)TIV7 (408-411)S9 (420-423)TII4 (426-429)AH2 (51-63)AH11 (284-295)TIV1 (97-100)TIV4 (207-210)S11 (435-442)TIV5 (237-240)S6 (280-282)TIV6 (320-323)AH1 (36-45)Updating...
connected with : NaN
molecule tags Transferase
source organism Homo sapiens
publication title Structural Basis for Non-Competitive Product Inhibition in Human Thymidine Phosphorylase: Implications for Drug Design.
pubmed doi rcsb
molecule keywords THYMIDINE PHOSPHORYLASE
total genus 159
structure length 446
sequence length 446
chains with identical sequence B, C, D
ec nomenclature ec 2.4.2.4: Thymidine phosphorylase.
pdb deposition date 2006-08-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
A PF07831 PYNP_C Pyrimidine nucleoside phosphorylase C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 2j0fA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 2j0fA02
3.90.1170.30 Alpha Beta Alpha-Beta Complex Aldehyde Oxidoreductase; domain 3 Pyrimidine nucleoside phosphorylase-like, C-terminal domain 2j0fA03
5EP8A 3R6CA 3GBRA 5C7SA 4ZOKA 4YI7A 2TPTA 4GKMA 4X58A 1V8GA 4X59A 4OWMA 5BO2A 4YYYA 4EADA 1ZVWA 4GA4A 3UU1A 5BYTA 1AZYA 5EY3A 4OWNA 4ZOJA 1KHDA 4X5BA 4EAFA 1VQUA 4X46A 1ZYKA 4XR5A 2DSJA 1ZXYA 4GA5A 4GTNA 2WK6A 4OWOA 4YEKA 2BPQA 2ELCA 1OTPA 1GXBA 4OWSA 1KGZA 3R88A 3QQSA 5C2LA 3QSAA 3QS8A 4N5VA 5C1RA 4MUOA 4M0RA 5BO3A 3QR9A 4X5DA 4ZOFA 4GA6A 2J0FA 4GIUA 4X5CA 1O17A 2WK5A 4X5AA 2GVQA 4OWVA 4N93A 1UOUA 4IJ1A 3H5QA 4OWQA 3TWPA 4ZTVA 4HKMA 4N8QA 4X5EA 5BNEA 1BRWA 4OWUA 4LHMA
chains in the Genus database with same CATH superfamily
5EP8A 4C7YA 1VLBA 3CCEH 5HL7J 3CC4H 3CMAH 3C2EA 1KD1J 1VQ4H 1VQNH 1Q81J 1N8RJ 2W3SB 1K73J 3R6CA 1FMAE 3GBRA 3G4SH 3C2FA 3C2VA 3EUB4 1FIQC 3CCMH 3CCJH 1VQ7H 5MPOC 1SB3A 5C7SA 1Q86J 3CCLH 4ZOKA 3CCUH 4YI7A 3J7ZM 2TPTA 4GKMA 4KWWA 5AYYA 1M90J 4ZOHA 1NVIE 4X58A 3VMMA 1V8GA 3OW2H 4X59A 1RM6A 5HUPA 3FC4A 3I56H 3I55H 1QPQA 5AYZA 3CCSH 3PIPJ 4OWMA 3CMEH 1VQLH 5BO2A 1X1OA 4YYYA 1O4UA 4EADA 1ZVWA 4US8A 2W55B 1K8AJ 2QA4H 1JJ2H 2W54B 2B7QA 1DGJA 2B7PA 1QPOA 1RRZA 3B9JC 4KWVA 3PIOJ 1YTEA 4GA4A 4WF9J 1N61B 3CF5J 1KC8J 1VQ8H 3UU1A 5H1SO 5BYTA 1AZYA 4IO9J 1M1KJ 1FM0E 5EY3A 1WKIA 4WFAJ 4I9AA 2QIEA 2OTLH 3DLLJ 1N63B 4OWNA 2B7NA 3AMZA 3AM9A 2WP4A 3TQVA 1Q82J 4ZOJA 2W3RB 1KHDA 5HULA 4X5BA 4EAFA 3NVYC 1VQUA 4AP8A 4X46A 5JVHJ 3RPFA 1QVGH 3CD6H 1RF8B 2ZJQJ 1ZYKA 4C80A 3NVVC 3G71H 1YIJH 4XR5A 2DSJA 3PAJA 4WFNJ 5DM7J 1ZXYA 1N60B 4UY8M 4U67J 2I1OA 3NVZC 1VQOH 1VQ5H 1ZXIB 3ETRC 1FFUB 5GAGN 4GA5A 3CCVH 3FAHA 3GNNA 4GTNA 5GAHN 1JRPB 1YHQH 3NVWC 2WK6A 1YTKA 1YJNH 1K9MJ 1N62B 3SR6C 3G6EH 1QVFH 4OWOA 4YEKA 1YJWH 2JBMA 4IOAJ 3AN1A 1VQ9H 5AYXA 3CCRH 2OMDA 5GAEN 2BPQA 2ZJRJ 2ELCA 2I14A 1OTPA 1GXBA 1FFVB 4OWSA 1KGZA 3R88A 3BIIE 3CXCH 1QAPA 2E3TA 4F3FC 3QQSA 5AN9F 5C2LA 3QSAA 3QS8A 1VQKH 4N5VA 2OTJH 5C1RA 4MUOA 4IOCJ 4M0RA 5BO3A 3QR9A 3C2OA 3WO0A 5JVGJ 4X5DA 1NVJA 3WO1A 4ZOFA 3CCQH 4GA6A 2J0FA 1N5WB 2QEXH 1W2BH 4GIUA 3C2RA 2PA2A 3NRZC 4X5CA 1VQPH 1O17A 2WK5A 1S72H 1YTDA 1YJ9H 4X5AA 1YI2H 1YITH 4USAA 2GVQA 1QPRA 1FO4A 4OWVA 4WFBJ 4N93A 3CC7H 1V97A 3WNZA 1Y69K 1JROB 5GADN 1KQSH 3CC2H 1Q7YJ 1UOUA 1N5XA 3L0GA 4IJ1A 1QPNA 4C7ZA 5MLCO 3H5QA 4OWQA 3TWPA 4ZTVA 4HKMA 5HUOA 4N8QA 1VDVA 1WYGA 3NS1C 4X5EA 3CPWH 5BNEA 5DM6J 1BRWA 2Q5WE 2ZJPJ 4OWUA 4WCEJ 1VQMH 1NJIJ 1SIJA 4LHMA 4US9A 1VQ6H 3L4PA
chains in the Genus database with same CATH topology
5EP8A 3R6CA 3GBRA 5C7SA 4ZOKA 4YI7A 2TPTA 4GKMA 4X58A 1V8GA 4X59A 4OWMA 5BO2A 4YYYA 4EADA 1ZVWA 4GA4A 3UU1A 5BYTA 1AZYA 5EY3A 4OWNA 4ZOJA 1KHDA 4X5BA 4EAFA 1VQUA 4X46A 1ZYKA 4XR5A 2DSJA 1ZXYA 4GA5A 4GTNA 2WK6A 4OWOA 4YEKA 2BPQA 2ELCA 1OTPA 1GXBA 4OWSA 1KGZA 3R88A 3QQSA 5C2LA 3QSAA 3QS8A 4N5VA 5C1RA 4MUOA 4M0RA 5BO3A 3QR9A 4X5DA 4ZOFA 4GA6A 2J0FA 4GIUA 4X5CA 1O17A 2WK5A 4X5AA 2GVQA 4OWVA 4N93A 1UOUA 4IJ1A 3H5QA 4OWQA 3TWPA 4ZTVA 4HKMA 4N8QA 4X5EA 5BNEA 1BRWA 4OWUA 4LHMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5EP8 A;  3R6C A;  3GBR A;  5C7S A;  4ZOK A;  4YI7 A;  2TPT A;  4GKM A;  4X58 A;  1V8G A;  4X59 A;  4OWM A;  5BO2 A;  4YYY A;  4EAD A;  1ZVW A;  4GA4 A;  3UU1 A;  5BYT A;  1AZY A;  5EY3 A;  4OWN A;  4ZOJ A;  1KHD A;  4X5B A;  4EAF A;  1VQU A;  4X46 A;  1ZYK A;  4XR5 A;  2DSJ A;  1ZXY A;  4GA5 A;  4GTN A;  2WK6 A;  4OWO A;  4YEK A;  2BPQ A;  2ELC A;  1OTP A;  1GXB A;  4OWS A;  1KGZ A;  3R88 A;  3QQS A;  5C2L A;  3QSA A;  3QS8 A;  4N5V A;  5C1R A;  4MUO A;  4M0R A;  5BO3 A;  3QR9 A;  4X5D A;  4ZOF A;  4GA6 A;  2J0F A;  4GIU A;  4X5C A;  1O17 A;  2WK5 A;  4X5A A;  2GVQ A;  4OWV A;  4N93 A;  1UOU A;  4IJ1 A;  3H5Q A;  4OWQ A;  3TWP A;  4ZTV A;  4HKM A;  4N8Q A;  4X5E A;  5BNE A;  1BRW A;  4OWU A;  4LHM A; 
#chains in the Genus database with same CATH topology
 5EP8 A;  4C7Y A;  1VLB A;  3CCE H;  5HL7 J;  3CC4 H;  3CMA H;  3C2E A;  1KD1 J;  1VQ4 H;  1VQN H;  1Q81 J;  1N8R J;  2W3S B;  1K73 J;  3R6C A;  1FMA E;  3GBR A;  3G4S H;  3C2F A;  3C2V A;  3EUB 4;  1FIQ C;  3CCM H;  3CCJ H;  1VQ7 H;  5MPO C;  1SB3 A;  5C7S A;  1Q86 J;  3CCL H;  4ZOK A;  3CCU H;  4YI7 A;  3J7Z M;  2TPT A;  4GKM A;  4KWW A;  5AYY A;  1M90 J;  4ZOH A;  1NVI E;  4X58 A;  3VMM A;  1V8G A;  3OW2 H;  4X59 A;  1RM6 A;  5HUP A;  3FC4 A;  3I56 H;  3I55 H;  1QPQ A;  5AYZ A;  3CCS H;  3PIP J;  4OWM A;  3CME H;  1VQL H;  5BO2 A;  1X1O A;  4YYY A;  1O4U A;  4EAD A;  1ZVW A;  4US8 A;  2W55 B;  1K8A J;  2QA4 H;  1JJ2 H;  2W54 B;  2B7Q A;  1DGJ A;  2B7P A;  1QPO A;  1RRZ A;  3B9J C;  4KWV A;  3PIO J;  1YTE A;  4GA4 A;  4WF9 J;  1N61 B;  3CF5 J;  1KC8 J;  1VQ8 H;  3UU1 A;  5H1S O;  5BYT A;  1AZY A;  4IO9 J;  1M1K J;  1FM0 E;  5EY3 A;  1WKI A;  4WFA J;  4I9A A;  2QIE A;  2OTL H;  3DLL J;  1N63 B;  4OWN A;  2B7N A;  3AMZ A;  3AM9 A;  2WP4 A;  3TQV A;  1Q82 J;  4ZOJ A;  2W3R B;  1KHD A;  5HUL A;  4X5B A;  4EAF A;  3NVY C;  1VQU A;  4AP8 A;  4X46 A;  5JVH J;  3RPF A;  1QVG H;  3CD6 H;  1RF8 B;  2ZJQ J;  1ZYK A;  4C80 A;  3NVV C;  3G71 H;  1YIJ H;  4XR5 A;  2DSJ A;  3PAJ A;  4WFN J;  5DM7 J;  1ZXY A;  1N60 B;  4UY8 M;  4U67 J;  2I1O A;  3NVZ C;  1VQO H;  1VQ5 H;  1ZXI B;  3ETR C;  1FFU B;  5GAG N;  4GA5 A;  3CCV H;  3FAH A;  3GNN A;  4GTN A;  5GAH N;  1JRP B;  1YHQ H;  3NVW C;  2WK6 A;  1YTK A;  1YJN H;  1K9M J;  1N62 B;  3SR6 C;  3G6E H;  1QVF H;  4OWO A;  4YEK A;  1YJW H;  2JBM A;  4IOA J;  3AN1 A;  1VQ9 H;  5AYX A;  3CCR H;  2OMD A;  5GAE N;  2BPQ A;  2ZJR J;  2ELC A;  2I14 A;  1OTP A;  1GXB A;  1FFV B;  4OWS A;  1KGZ A;  3R88 A;  3BII E;  3CXC H;  1QAP A;  2E3T A;  4F3F C;  3QQS A;  5AN9 F;  5C2L A;  3QSA A;  3QS8 A;  1VQK H;  4N5V A;  2OTJ H;  5C1R A;  4MUO A;  4IOC J;  4M0R A;  5BO3 A;  3QR9 A;  3C2O A;  3WO0 A;  5JVG J;  4X5D A;  1NVJ A;  3WO1 A;  4ZOF A;  3CCQ H;  4GA6 A;  2J0F A;  1N5W B;  2QEX H;  1W2B H;  4GIU A;  3C2R A;  2PA2 A;  3NRZ C;  4X5C A;  1VQP H;  1O17 A;  2WK5 A;  1S72 H;  1YTD A;  1YJ9 H;  4X5A A;  1YI2 H;  1YIT H;  4USA A;  2GVQ A;  1QPR A;  1FO4 A;  4OWV A;  4WFB J;  4N93 A;  3CC7 H;  1V97 A;  3WNZ A;  1Y69 K;  1JRO B;  5GAD N;  1KQS H;  3CC2 H;  1Q7Y J;  1UOU A;  1N5X A;  3L0G A;  4IJ1 A;  1QPN A;  4C7Z A;  5MLC O;  3H5Q A;  4OWQ A;  3TWP A;  4ZTV A;  4HKM A;  5HUO A;  4N8Q A;  1VDV A;  1WYG A;  3NS1 C;  4X5E A;  3CPW H;  5BNE A;  5DM6 J;  1BRW A;  2Q5W E;  2ZJP J;  4OWU A;  4WCE J;  1VQM H;  1NJI J;  1SIJ A;  4LHM A;  4US9 A;  1VQ6 H;  3L4P A; 
#chains in the Genus database with same CATH homology
 5EP8 A;  3R6C A;  3GBR A;  5C7S A;  4ZOK A;  4YI7 A;  2TPT A;  4GKM A;  4X58 A;  1V8G A;  4X59 A;  4OWM A;  5BO2 A;  4YYY A;  4EAD A;  1ZVW A;  4GA4 A;  3UU1 A;  5BYT A;  1AZY A;  5EY3 A;  4OWN A;  4ZOJ A;  1KHD A;  4X5B A;  4EAF A;  1VQU A;  4X46 A;  1ZYK A;  4XR5 A;  2DSJ A;  1ZXY A;  4GA5 A;  4GTN A;  2WK6 A;  4OWO A;  4YEK A;  2BPQ A;  2ELC A;  1OTP A;  1GXB A;  4OWS A;  1KGZ A;  3R88 A;  3QQS A;  5C2L A;  3QSA A;  3QS8 A;  4N5V A;  5C1R A;  4MUO A;  4M0R A;  5BO3 A;  3QR9 A;  4X5D A;  4ZOF A;  4GA6 A;  2J0F A;  4GIU A;  4X5C A;  1O17 A;  2WK5 A;  4X5A A;  2GVQ A;  4OWV A;  4N93 A;  1UOU A;  4IJ1 A;  3H5Q A;  4OWQ A;  3TWP A;  4ZTV A;  4HKM A;  4N8Q A;  4X5E A;  5BNE A;  1BRW A;  4OWU A;  4LHM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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