The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
159
|
sequence length |
446
|
structure length |
446
|
Chain Sequence |
KQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGAGAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPLPFAELVLP
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Structural Basis for Non-Competitive Product Inhibition in Human Thymidine Phosphorylase: Implications for Drug Design.
pubmed doi rcsb |
| molecule tags |
Transferase
|
| source organism |
Homo sapiens
|
| molecule keywords |
THYMIDINE PHOSPHORYLASE
|
| total genus |
159
|
| structure length |
446
|
| sequence length |
446
|
| chains with identical sequence |
B, C, D
|
| ec nomenclature |
ec
2.4.2.4: Thymidine phosphorylase. |
| pdb deposition date | 2006-08-02 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00591 | Glycos_transf_3 | Glycosyl transferase family, a/b domain |
| A | PF02885 | Glycos_trans_3N | Glycosyl transferase family, helical bundle domain |
| A | PF07831 | PYNP_C | Pyrimidine nucleoside phosphorylase C-terminal domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Up-down Bundle | Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 | Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C | ||
| Alpha Beta | 3-Layer(aba) Sandwich | Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 | Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain | ||
| Alpha Beta | Alpha-Beta Complex | Aldehyde Oxidoreductase; domain 3 | Pyrimidine nucleoside phosphorylase-like, C-terminal domain |
#chains in the Genus database with same CATH superfamily 2TPT A; 5BNE A; 4OWO A; 4ZOF A; 4OWV A; 4X5D A; 4X46 A; 4M0R A; 1KGZ A; 4ZOK A; 2DSJ A; 4GKM A; 4YEK A; 3QR9 A; 4OWN A; 4HKM A; 5C1R A; 4N8Q A; 4X5A A; 2GVQ A; 5BO3 A; 4XR5 A; 5BO2 A; 4ZOJ A; 4GA6 A; 1O17 A; 4X5C A; 4OWM A; 4ZTV A; 3TWP A; 4EAD A; 5C7S A; 4X5B A; 1BRW A; 3QS8 A; 2J0F A; 5BYT A; 1UOU A; 4MUO A; 2WK5 A; 4N5V A; 3H5Q A; 1KHD A; 3UU1 A; 3GBR A; 4OWU A; 5C2L A; 1OTP A; 4LHM A; 3R88 A; 1V8G A; 3QSA A; 4GIU A; 1AZY A; 5EP8 A; 4N93 A; 3QQS A; 3R6C A; 4IJ1 A; 5EY3 A; 1GXB A; 2BPQ A; 4OWS A; 2ELC A; 4X58 A; 1VQU A; 4YYY A; 4X5E A; 1ZXY A; 1ZYK A; 4OWQ A; 4EAF A; 1ZVW A; 4GA4 A; 4GA5 A; 2WK6 A; 4GTN A; 4X59 A; 4YI7 A; #chains in the Genus database with same CATH topology 1VQM H; 4KWW A; 4US9 A; 2TPT A; 1KQS H; 2JBM A; 1VQ4 H; 3CCJ H; 5BNE A; 1VLB A; 4C7Y A; 4US8 A; 3EUB 4; 2I1O A; 4OWO A; 1NVI E; 3CME H; 4ZOF A; 5AN9 F; 1JRP B; 3CPW H; 2W54 B; 1Q7Y J; 1NJI J; 4OWV A; 3NVY C; 2W55 B; 3VMM A; 4X5D A; 2W3S B; 2W3R B; 3BII E; 3OW2 H; 5GAH N; 4USA A; 1KD1 J; 4X46 A; 1VQ8 H; 3CCL H; 1N8R J; 4M0R A; 2PA2 A; 4C7Z A; 1KGZ A; 4ZOK A; 2DSJ A; 3CCE H; 1FFV B; 4WCE J; 4IOC J; 1VQ9 H; 4GKM A; 1YTE A; 2B7Q A; 3NS1 C; 3CCR H; 4YEK A; 3C2F A; 1M1K J; 3QR9 A; 1VQP H; 5HUO A; 4OWN A; 1ZXI B; 4AP8 A; 1Q82 J; 1VQK H; 5AYY A; 1YIT H; 1QVG H; 4HKM A; 1SB3 A; 1N63 B; 2QEX H; 5C1R A; 1X1O A; 3CC2 H; 1K9M J; 4UY8 M; 3TQV A; 3CCU H; 1Y69 K; 4N8Q A; 4X5A A; 2B7N A; 3CC7 H; 2GVQ A; 5BO3 A; 5GAG N; 1YHQ H; 3CCM H; 1N61 B; 1M90 J; 5JVG J; 4XR5 A; 1JRO B; 1YIJ H; 5BO2 A; 1W2B H; 1QVF H; 4ZOJ A; 1Q86 J; 1RF8 B; 4GA6 A; 3FAH A; 1O17 A; 4X5C A; 3CCS H; 3PIO J; 4IO9 J; 2OTJ H; 1N62 B; 1VQN H; 1KC8 J; 5MLC O; 4OWM A; 1RM6 A; 3B9J C; 1N5X A; 4ZTV A; 5DM7 J; 1JJ2 H; 3TWP A; 4EAD A; 3C2V A; 1Q81 J; 3PAJ A; 5C7S A; 3CCV H; 1YTD A; 5H1S O; 1YJW H; 3J7Z M; 4F3F C; 3G6E H; 1FO4 A; 3CC4 H; 4X5B A; 3AN1 A; 3CF5 J; 1BRW A; 5DM6 J; 3SR6 C; 1QPO A; 2ZJR J; 2Q5W E; 3QS8 A; 1VQ5 H; 1V97 A; 4WFN J; 2J0F A; 2E3T A; 1VDV A; 2OTL H; 5AYX A; 3NVZ C; 3DLL J; 5BYT A; 1UOU A; 1K73 J; 4MUO A; 1SIJ A; 2WK5 A; 1QPR A; 4N5V A; 3H5Q A; 3I56 H; 1WYG A; 1KHD A; 4KWV A; 3AM9 A; 3UU1 A; 3GBR A; 3WO1 A; 4OWU A; 1YJ9 H; 5C2L A; 1OTP A; 2QIE A; 2OMD A; 3RPF A; 1N5W B; 1K8A J; 4LHM A; 1VQ6 H; 1O4U A; 1VQL H; 3WNZ A; 3I55 H; 3R88 A; 2I14 A; 1V8G A; 5HUL A; 4WFB J; 4WFA J; 4ZOH A; 3QSA A; 1NVJ A; 4GIU A; 1AZY A; 3G4S H; 5EP8 A; 1YTK A; 4C80 A; 4N93 A; 3QQS A; 2B7P A; 3CCQ H; 3R6C A; 1FIQ C; 3FC4 A; 4IOA J; 3ETR C; 4IJ1 A; 5AYZ A; 3CXC H; 1YI2 H; 5EY3 A; 3L0G A; 5HL7 J; 3C2R A; 4WF9 J; 1S72 H; 3NVV C; 1GXB A; 2BPQ A; 4OWS A; 2ELC A; 1DGJ A; 1WKI A; 1FFU B; 2ZJQ J; 4X58 A; 1VQU A; 1QPN A; 3GNN A; 4YYY A; 4I9A A; 4X5E A; 1QAP A; 1ZXY A; 1ZYK A; 1N60 B; 3L4P A; 3WO0 A; 1RRZ A; 2WP4 A; 4OWQ A; 1QPQ A; 3C2O A; 3G71 H; 4EAF A; 5HUP A; 3AMZ A; 3CMA H; 3CD6 H; 4U67 J; 1YJN H; 5MPO C; 5GAD N; 3PIP J; 5GAE N; 1VQO H; 1ZVW A; 3C2E A; 1FM0 E; 4GA4 A; 2ZJP J; 4GA5 A; 1FMA E; 1VQ7 H; 5JVH J; 3NVW C; 3NRZ C; 2WK6 A; 4GTN A; 4X59 A; 4YI7 A; 2QA4 H; #chains in the Genus database with same CATH homology 2TPT A; 5BNE A; 4OWO A; 4ZOF A; 4OWV A; 4X5D A; 4X46 A; 4M0R A; 1KGZ A; 4ZOK A; 2DSJ A; 4GKM A; 4YEK A; 3QR9 A; 4OWN A; 4HKM A; 5C1R A; 4N8Q A; 4X5A A; 2GVQ A; 5BO3 A; 4XR5 A; 5BO2 A; 4ZOJ A; 4GA6 A; 1O17 A; 4X5C A; 4OWM A; 4ZTV A; 3TWP A; 4EAD A; 5C7S A; 4X5B A; 1BRW A; 3QS8 A; 2J0F A; 5BYT A; 1UOU A; 4MUO A; 2WK5 A; 4N5V A; 3H5Q A; 1KHD A; 3UU1 A; 3GBR A; 4OWU A; 5C2L A; 1OTP A; 4LHM A; 3R88 A; 1V8G A; 3QSA A; 4GIU A; 1AZY A; 5EP8 A; 4N93 A; 3QQS A; 3R6C A; 4IJ1 A; 5EY3 A; 1GXB A; 2BPQ A; 4OWS A; 2ELC A; 4X58 A; 1VQU A; 4YYY A; 4X5E A; 1ZXY A; 1ZYK A; 4OWQ A; 4EAF A; 1ZVW A; 4GA4 A; 4GA5 A; 2WK6 A; 4GTN A; 4X59 A; 4YI7 A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
