2WK5A

Structural features of native human thymidine phosphorylase and in complex with 5-iodouracil
Total Genus 145
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
145
sequence length
448
structure length
448
Chain Sequence
EPKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of Native Human Thymidine Phosphorylase and in Complex with 5-Iodouracil.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords THYMIDINE PHOSPHORYLASE
total genus 145
structure length 448
sequence length 448
chains with identical sequence B, C, D
ec nomenclature ec 2.4.2.4: Thymidine phosphorylase.
pdb deposition date 2009-06-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
A PF07831 PYNP_C Pyrimidine nucleoside phosphorylase C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 2wk5A01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 2wk5A02
3.90.1170.30 Alpha Beta Alpha-Beta Complex Aldehyde Oxidoreductase; domain 3 Pyrimidine nucleoside phosphorylase-like, C-terminal domain 2wk5A03
4GIUA 4X5EA 5C2LA 4HKMA 4N5VA 4OWUA 4OWOA 4OWMA 5BYTA 4GA6A 2BPQA 4ZOFA 3QR9A 4EAFA 4IJ1A 2DSJA 1ZVWA 4X59A 3H5QA 3R6CA 1O17A 2GVQA 4X5AA 3QQSA 1AZYA 4ZTVA 1V8GA 5C1RA 5C7SA 5BNEA 4XR5A 2WK5A 4N8QA 1GXBA 1OTPA 4M0RA 4X5BA 5BO3A 4OWQA 5EP8A 3UU1A 4GA5A 2TPTA 4GA4A 3QS8A 4X5CA 4YI7A 3R88A 4OWNA 4X5DA 1UOUA 4ZOJA 2ELCA 2J0FA 1KGZA 4GKMA 4X58A 4YYYA 5BO2A 4ZOKA 4EADA 4X46A 4LHMA 4YEKA 1KHDA 1BRWA 3GBRA 4MUOA 4OWSA 3QSAA 1VQUA 1ZXYA 4OWVA 4GTNA 5EY3A 2WK6A 4N93A 1ZYKA 3TWPA
chains in the Genus database with same CATH superfamily
2W55B 1S72H 4KWVA 3SR6C 3C2OA 4C80A 4GIUA 4X5EA 1WYGA 5C2LA 2OTJH 1VQ7H 4HKMA 1FMAE 4N5VA 4OWUA 5HL7J 4OWOA 4IOCJ 4OWMA 4WFBJ 2OMDA 1ZXIB 5MLCO 3G6EH 1W2BH 5BYTA 1YI2H 1YITH 1Q82J 1M1KJ 1YHQH 5GAHN 2QEXH 1VQPH 3CC4H 1YTEA 3PIOJ 2I14A 3CCLH 3CCEH 3CCUH 4GA6A 1FM0E 1KC8J 2BPQA 3CPWH 3AN1A 5HUPA 4ZOFA 1QPRA 3QR9A 3G4SH 3CMAH 4EAFA 3CC2H 4UY8M 1KQSH 3CCMH 4IJ1A 1Q7YJ 2DSJA 1ZVWA 1N63B 4X59A 1JRPB 3H5QA 5HUOA 1K8AJ 5HULA 3R6CA 1YTDA 1QAPA 1O17A 1O4UA 3C2VA 2GVQA 4X5AA 3NS1C 1FFVB 3QQSA 1AZYA 1DGJA 3OW2H 4ZTVA 1V8GA 2B7QA 5AYXA 5C1RA 3I55H 5C7SA 2JBMA 5BNEA 5JVGJ 4XR5A 2WK5A 1VQ4H 4N8QA 4WF9J 1FFUB 1GXBA 1QVFH 1VQ9H 3CF5J 1OTPA 3CXCH 4M0RA 1JJ2H 4C7YA 3CCSH 1RM6A 4X5BA 2OTLH 3CCJH 2QA4H 5AN9F 1FO4A 1YJ9H 5BO3A 5MPOC 1YTKA 4WCEJ 4OWQA 3I56H 5EP8A 1QPQA 3UU1A 1NVIE 2I1OA 3PIPJ 3FC4A 1N60B 1K73J 1VQNH 4GA5A 4IO9J 1JROB 2TPTA 1NVJA 4GA4A 3BIIE 2B7NA 4USAA 3PAJA 3QS8A 1Y69K 3J7ZM 4KWWA 4X5CA 4YI7A 3R88A 2QIEA 4OWNA 4X5DA 3CC7H 1VLBA 1UOUA 1SIJA 1Q81J 3VMMA 3L4PA 4ZOJA 2ELCA 2J0FA 1KGZA 1YIJH 3NVZC 2ZJQJ 1VQ5H 4GKMA 4X58A 5AYYA 4YYYA 3DLLJ 5BO2A 3CCVH 3WO0A 4I9AA 3RPFA 1V97A 1N61B 3ETRC 1VQLH 4ZOKA 4EADA 5H1SO 4X46A 1YJNH 2W54B 4US8A 3WO1A 3NVYC 1X1OA 2W3RB 1WKIA 5DM6J 3CCRH 1VQMH 4U67J 3G71H 4LHMA 3NVWC 5GADN 4IOAJ 1QPNA 5AYZA 1QVGH 1N5XA 4YEKA 3L0GA 2ZJRJ 1KHDA 4US9A 1YJWH 2E3TA 3C2FA 5GAGN 3CCQH 1RF8B 1FIQC 3C2RA 4AP8A 1BRWA 3GBRA 4MUOA 1QPOA 4OWSA 3QSAA 4WFAJ 1VQUA 3B9JC 4C7ZA 1ZXYA 1N5WB 2WP4A 1N62B 3CD6H 4ZOHA 4OWVA 2PA2A 3AM9A 3TQVA 1Q86J 1VQ6H 5GAEN 1KD1J 3EUB4 3CMEH 1SB3A 3GNNA 3NRZC 3C2EA 5JVHJ 4GTNA 5DM7J 3AMZA 5EY3A 1VQOH 1N8RJ 1K9MJ 2WK6A 4N93A 1VQ8H 1NJIJ 3NVVC 3WNZA 1VQKH 2Q5WE 2B7PA 4WFNJ 4F3FC 2ZJPJ 1ZYKA 1M90J 2W3SB 3TWPA 3FAHA 1RRZA 1VDVA
chains in the Genus database with same CATH topology
4GIUA 4X5EA 5C2LA 4HKMA 4N5VA 4OWUA 4OWOA 4OWMA 5BYTA 4GA6A 2BPQA 4ZOFA 3QR9A 4EAFA 4IJ1A 2DSJA 1ZVWA 4X59A 3H5QA 3R6CA 1O17A 2GVQA 4X5AA 3QQSA 1AZYA 4ZTVA 1V8GA 5C1RA 5C7SA 5BNEA 4XR5A 2WK5A 4N8QA 1GXBA 1OTPA 4M0RA 4X5BA 5BO3A 4OWQA 5EP8A 3UU1A 4GA5A 2TPTA 4GA4A 3QS8A 4X5CA 4YI7A 3R88A 4OWNA 4X5DA 1UOUA 4ZOJA 2ELCA 2J0FA 1KGZA 4GKMA 4X58A 4YYYA 5BO2A 4ZOKA 4EADA 4X46A 4LHMA 4YEKA 1KHDA 1BRWA 3GBRA 4MUOA 4OWSA 3QSAA 1VQUA 1ZXYA 4OWVA 4GTNA 5EY3A 2WK6A 4N93A 1ZYKA 3TWPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4GIU A;  4X5E A;  5C2L A;  4HKM A;  4N5V A;  4OWU A;  4OWO A;  4OWM A;  5BYT A;  4GA6 A;  2BPQ A;  4ZOF A;  3QR9 A;  4EAF A;  4IJ1 A;  2DSJ A;  1ZVW A;  4X59 A;  3H5Q A;  3R6C A;  1O17 A;  2GVQ A;  4X5A A;  3QQS A;  1AZY A;  4ZTV A;  1V8G A;  5C1R A;  5C7S A;  5BNE A;  4XR5 A;  2WK5 A;  4N8Q A;  1GXB A;  1OTP A;  4M0R A;  4X5B A;  5BO3 A;  4OWQ A;  5EP8 A;  3UU1 A;  4GA5 A;  2TPT A;  4GA4 A;  3QS8 A;  4X5C A;  4YI7 A;  3R88 A;  4OWN A;  4X5D A;  1UOU A;  4ZOJ A;  2ELC A;  2J0F A;  1KGZ A;  4GKM A;  4X58 A;  4YYY A;  5BO2 A;  4ZOK A;  4EAD A;  4X46 A;  4LHM A;  4YEK A;  1KHD A;  1BRW A;  3GBR A;  4MUO A;  4OWS A;  3QSA A;  1VQU A;  1ZXY A;  4OWV A;  4GTN A;  5EY3 A;  2WK6 A;  4N93 A;  1ZYK A;  3TWP A; 
#chains in the Genus database with same CATH topology
 2W55 B;  1S72 H;  4KWV A;  3SR6 C;  3C2O A;  4C80 A;  4GIU A;  4X5E A;  1WYG A;  5C2L A;  2OTJ H;  1VQ7 H;  4HKM A;  1FMA E;  4N5V A;  4OWU A;  5HL7 J;  4OWO A;  4IOC J;  4OWM A;  4WFB J;  2OMD A;  1ZXI B;  5MLC O;  3G6E H;  1W2B H;  5BYT A;  1YI2 H;  1YIT H;  1Q82 J;  1M1K J;  1YHQ H;  5GAH N;  2QEX H;  1VQP H;  3CC4 H;  1YTE A;  3PIO J;  2I14 A;  3CCL H;  3CCE H;  3CCU H;  4GA6 A;  1FM0 E;  1KC8 J;  2BPQ A;  3CPW H;  3AN1 A;  5HUP A;  4ZOF A;  1QPR A;  3QR9 A;  3G4S H;  3CMA H;  4EAF A;  3CC2 H;  4UY8 M;  1KQS H;  3CCM H;  4IJ1 A;  1Q7Y J;  2DSJ A;  1ZVW A;  1N63 B;  4X59 A;  1JRP B;  3H5Q A;  5HUO A;  1K8A J;  5HUL A;  3R6C A;  1YTD A;  1QAP A;  1O17 A;  1O4U A;  3C2V A;  2GVQ A;  4X5A A;  3NS1 C;  1FFV B;  3QQS A;  1AZY A;  1DGJ A;  3OW2 H;  4ZTV A;  1V8G A;  2B7Q A;  5AYX A;  5C1R A;  3I55 H;  5C7S A;  2JBM A;  5BNE A;  5JVG J;  4XR5 A;  2WK5 A;  1VQ4 H;  4N8Q A;  4WF9 J;  1FFU B;  1GXB A;  1QVF H;  1VQ9 H;  3CF5 J;  1OTP A;  3CXC H;  4M0R A;  1JJ2 H;  4C7Y A;  3CCS H;  1RM6 A;  4X5B A;  2OTL H;  3CCJ H;  2QA4 H;  5AN9 F;  1FO4 A;  1YJ9 H;  5BO3 A;  5MPO C;  1YTK A;  4WCE J;  4OWQ A;  3I56 H;  5EP8 A;  1QPQ A;  3UU1 A;  1NVI E;  2I1O A;  3PIP J;  3FC4 A;  1N60 B;  1K73 J;  1VQN H;  4GA5 A;  4IO9 J;  1JRO B;  2TPT A;  1NVJ A;  4GA4 A;  3BII E;  2B7N A;  4USA A;  3PAJ A;  3QS8 A;  1Y69 K;  3J7Z M;  4KWW A;  4X5C A;  4YI7 A;  3R88 A;  2QIE A;  4OWN A;  4X5D A;  3CC7 H;  1VLB A;  1UOU A;  1SIJ A;  1Q81 J;  3VMM A;  3L4P A;  4ZOJ A;  2ELC A;  2J0F A;  1KGZ A;  1YIJ H;  3NVZ C;  2ZJQ J;  1VQ5 H;  4GKM A;  4X58 A;  5AYY A;  4YYY A;  3DLL J;  5BO2 A;  3CCV H;  3WO0 A;  4I9A A;  3RPF A;  1V97 A;  1N61 B;  3ETR C;  1VQL H;  4ZOK A;  4EAD A;  5H1S O;  4X46 A;  1YJN H;  2W54 B;  4US8 A;  3WO1 A;  3NVY C;  1X1O A;  2W3R B;  1WKI A;  5DM6 J;  3CCR H;  1VQM H;  4U67 J;  3G71 H;  4LHM A;  3NVW C;  5GAD N;  4IOA J;  1QPN A;  5AYZ A;  1QVG H;  1N5X A;  4YEK A;  3L0G A;  2ZJR J;  1KHD A;  4US9 A;  1YJW H;  2E3T A;  3C2F A;  5GAG N;  3CCQ H;  1RF8 B;  1FIQ C;  3C2R A;  4AP8 A;  1BRW A;  3GBR A;  4MUO A;  1QPO A;  4OWS A;  3QSA A;  4WFA J;  1VQU A;  3B9J C;  4C7Z A;  1ZXY A;  1N5W B;  2WP4 A;  1N62 B;  3CD6 H;  4ZOH A;  4OWV A;  2PA2 A;  3AM9 A;  3TQV A;  1Q86 J;  1VQ6 H;  5GAE N;  1KD1 J;  3EUB 4;  3CME H;  1SB3 A;  3GNN A;  3NRZ C;  3C2E A;  5JVH J;  4GTN A;  5DM7 J;  3AMZ A;  5EY3 A;  1VQO H;  1N8R J;  1K9M J;  2WK6 A;  4N93 A;  1VQ8 H;  1NJI J;  3NVV C;  3WNZ A;  1VQK H;  2Q5W E;  2B7P A;  4WFN J;  4F3F C;  2ZJP J;  1ZYK A;  1M90 J;  2W3S B;  3TWP A;  3FAH A;  1RRZ A;  1VDV A; 
#chains in the Genus database with same CATH homology
 4GIU A;  4X5E A;  5C2L A;  4HKM A;  4N5V A;  4OWU A;  4OWO A;  4OWM A;  5BYT A;  4GA6 A;  2BPQ A;  4ZOF A;  3QR9 A;  4EAF A;  4IJ1 A;  2DSJ A;  1ZVW A;  4X59 A;  3H5Q A;  3R6C A;  1O17 A;  2GVQ A;  4X5A A;  3QQS A;  1AZY A;  4ZTV A;  1V8G A;  5C1R A;  5C7S A;  5BNE A;  4XR5 A;  2WK5 A;  4N8Q A;  1GXB A;  1OTP A;  4M0R A;  4X5B A;  5BO3 A;  4OWQ A;  5EP8 A;  3UU1 A;  4GA5 A;  2TPT A;  4GA4 A;  3QS8 A;  4X5C A;  4YI7 A;  3R88 A;  4OWN A;  4X5D A;  1UOU A;  4ZOJ A;  2ELC A;  2J0F A;  1KGZ A;  4GKM A;  4X58 A;  4YYY A;  5BO2 A;  4ZOK A;  4EAD A;  4X46 A;  4LHM A;  4YEK A;  1KHD A;  1BRW A;  3GBR A;  4MUO A;  4OWS A;  3QSA A;  1VQU A;  1ZXY A;  4OWV A;  4GTN A;  5EY3 A;  2WK6 A;  4N93 A;  1ZYK A;  3TWP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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