4X46A

X-ray structure thymidine phosphorylase from salmonella typhimurium complex with so4 at 2.19 a
Total Genus 149
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
149
sequence length
440
structure length
440
Chain Sequence
MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLNLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGFDIFPDDNRFREIIQDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITGSILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGQLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPSDFVENYDKYLPTAMLSKAVYADTEGFISAMDTRALGMAVVSMGGGRRQASDTIDYSVGFTDMARLGDSIDGQRPLAVIHAKDEASWQEAAKAVKAAIILDDKAPASTPSVYRRITE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title X-RAY structure thymidine phosphorylase from Salmonella typhimurium complex with SO4 at 2.19 A
rcsb
molecule tags Transferase
source organism Salmonella enterica subsp. enterica serovar typhimurium
molecule keywords Thymidine phosphorylase
total genus 149
structure length 440
sequence length 440
chains with identical sequence B
ec nomenclature ec 2.4.2.4: Thymidine phosphorylase.
pdb deposition date 2014-12-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
A PF07831 PYNP_C Pyrimidine nucleoside phosphorylase C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 4x46A01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 4x46A02
3.90.1170.30 Alpha Beta Alpha-Beta Complex Aldehyde Oxidoreductase; domain 3 Pyrimidine nucleoside phosphorylase-like, C-terminal domain 4x46A03
1UOUA 4OWVA 4X5CA 2J0FA 4YEKA 4OWSA 5BO3A 3H5QA 4GKMA 4ZOKA 1ZXYA 2WK5A 4YYYA 5C7SA 4EAFA 3QQSA 4X58A 4ZOJA 4MUOA 4X46A 1VQUA 3R6CA 1ZYKA 1ZVWA 4ZTVA 1KHDA 4YI7A 5BO2A 4N5VA 4GA5A 1AZYA 3TWPA 1OTPA 1BRWA 3QS8A 4GA6A 4GIUA 4OWUA 3R88A 4M0RA 5C2LA 2GVQA 4HKMA 4N93A 2BPQA 2WK6A 4EADA 5BNEA 4OWNA 5C1RA 2ELCA 4OWQA 5BYTA 2DSJA 4X5DA 4X5AA 4OWMA 4XR5A 4LHMA 4N8QA 4X59A 1V8GA 4ZOFA 3GBRA 1GXBA 3QR9A 2TPTA 3UU1A 4X5BA 4GTNA 4OWOA 3QSAA 5EP8A 4IJ1A 1KGZA 4GA4A 1O17A 5EY3A 4X5EA
chains in the Genus database with same CATH superfamily
5GAEN 4U67J 1N60B 3NVWC 1SB3A 1KQSH 1UOUA 2W3SB 3I56H 3CCVH 4IOAJ 5H1SO 4OWVA 4X5CA 5DM7J 3G71H 1YJNH 3WNZA 1Q7YJ 5HULA 2J0FA 1VQ9H 4YEKA 3C2EA 1QPNA 2ZJQJ 4OWSA 4IOCJ 1YI2H 1VQNH 5BO3A 1Y69K 1N8RJ 3H5QA 5MLCO 3CCLH 1VQMH 1QPQA 1QPRA 4GKMA 2QA4H 2B7PA 5HUOA 3VMMA 4US8A 3CMAH 4ZOKA 1FFUB 3TQVA 3J7ZM 1ZXYA 1DGJA 2WK5A 4YYYA 2WP4A 5C7SA 3FC4A 3L4PA 5HUPA 3WO0A 5MPOC 4WFBJ 1N63B 3CCEH 4EAFA 3WO1A 3CCMH 1VQPH 3QQSA 1M90J 1VQ8H 1RRZA 1VQKH 4X58A 1Q82J 1N62B 4ZOJA 4KWVA 1VLBA 4MUOA 1YITH 2Q5WE 2B7NA 2OTLH 1QPOA 4X46A 4WFNJ 4WF9J 1O4UA 4KWWA 1VQUA 3R6CA 2W54B 1ZYKA 1ZVWA 4USAA 3RPFA 4ZTVA 3C2FA 1KHDA 2I1OA 3C2VA 4YI7A 2QEXH 3CCQH 3CF5J 1QVGH 2QIEA 1N61B 5DM6J 5BO2A 1YIJH 3CPWH 4N5VA 1JROB 1YTKA 4GA5A 1AZYA 3NRZC 3NVVC 3TWPA 1K8AJ 1VQ7H 5AYXA 2ZJPJ 1OTPA 5JVGJ 1JJ2H 1BRWA 3QS8A 4I9AA 4GA6A 1WYGA 3C2RA 4WFAJ 5JVHJ 3BIIE 3EUB4 3NS1C 3PAJA 5GAGN 4GIUA 4OWUA 1QAPA 5AN9F 3R88A 3CCUH 1M1KJ 1VQLH 3FAHA 1FO4A 3PIOJ 2B7QA 4M0RA 4AP8A 5C2LA 3CCRH 3CC7H 1KC8J 2OMDA 5HL7J 1VQ4H 1YTDA 2GVQA 3CCSH 2W55B 4HKMA 3AMZA 4N93A 2BPQA 1N5WB 3SR6C 1RM6A 2ZJRJ 1FFVB 3NVZC 1KD1J 1NVJA 2PA2A 2WK6A 1FM0E 3OW2H 3L0GA 5GAHN 3B9JC 4EADA 1NJIJ 5BNEA 4OWNA 1WKIA 5AYZA 3ETRC 4WCEJ 5C1RA 2ELCA 4ZOHA 4OWQA 3PIPJ 1VQ5H 1JRPB 4C7YA 4UY8M 1FMAE 1X1OA 3I55H 3CC2H 4F3FC 1VQ6H 2JBMA 1Q86J 5BYTA 1FIQC 1YHQH 2DSJA 5GADN 3C2OA 4X5DA 3AN1A 1S72H 3AM9A 2OTJH 1NVIE 4X5AA 1K73J 1RF8B 4OWMA 4XR5A 1YTEA 1Q81J 4LHMA 2I14A 1K9MJ 1N5XA 4N8QA 4X59A 3GNNA 1YJWH 1V8GA 4ZOFA 3G6EH 1W2BH 1YJ9H 3DLLJ 3CCJH 4US9A 3GBRA 1GXBA 3QR9A 2TPTA 3CC4H 3CD6H 1QVFH 3UU1A 4X5BA 4IO9J 4GTNA 4OWOA 3QSAA 2W3RB 5AYYA 5EP8A 4C7ZA 4IJ1A 1KGZA 3NVYC 3CXCH 1ZXIB 1SIJA 1V97A 4C80A 4GA4A 1O17A 1VDVA 5EY3A 2E3TA 1VQOH 3CMEH 4X5EA 3G4SH
chains in the Genus database with same CATH topology
1UOUA 4OWVA 4X5CA 2J0FA 4YEKA 4OWSA 5BO3A 3H5QA 4GKMA 4ZOKA 1ZXYA 2WK5A 4YYYA 5C7SA 4EAFA 3QQSA 4X58A 4ZOJA 4MUOA 4X46A 1VQUA 3R6CA 1ZYKA 1ZVWA 4ZTVA 1KHDA 4YI7A 5BO2A 4N5VA 4GA5A 1AZYA 3TWPA 1OTPA 1BRWA 3QS8A 4GA6A 4GIUA 4OWUA 3R88A 4M0RA 5C2LA 2GVQA 4HKMA 4N93A 2BPQA 2WK6A 4EADA 5BNEA 4OWNA 5C1RA 2ELCA 4OWQA 5BYTA 2DSJA 4X5DA 4X5AA 4OWMA 4XR5A 4LHMA 4N8QA 4X59A 1V8GA 4ZOFA 3GBRA 1GXBA 3QR9A 2TPTA 3UU1A 4X5BA 4GTNA 4OWOA 3QSAA 5EP8A 4IJ1A 1KGZA 4GA4A 1O17A 5EY3A 4X5EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1UOU A;  4OWV A;  4X5C A;  2J0F A;  4YEK A;  4OWS A;  5BO3 A;  3H5Q A;  4GKM A;  4ZOK A;  1ZXY A;  2WK5 A;  4YYY A;  5C7S A;  4EAF A;  3QQS A;  4X58 A;  4ZOJ A;  4MUO A;  4X46 A;  1VQU A;  3R6C A;  1ZYK A;  1ZVW A;  4ZTV A;  1KHD A;  4YI7 A;  5BO2 A;  4N5V A;  4GA5 A;  1AZY A;  3TWP A;  1OTP A;  1BRW A;  3QS8 A;  4GA6 A;  4GIU A;  4OWU A;  3R88 A;  4M0R A;  5C2L A;  2GVQ A;  4HKM A;  4N93 A;  2BPQ A;  2WK6 A;  4EAD A;  5BNE A;  4OWN A;  5C1R A;  2ELC A;  4OWQ A;  5BYT A;  2DSJ A;  4X5D A;  4X5A A;  4OWM A;  4XR5 A;  4LHM A;  4N8Q A;  4X59 A;  1V8G A;  4ZOF A;  3GBR A;  1GXB A;  3QR9 A;  2TPT A;  3UU1 A;  4X5B A;  4GTN A;  4OWO A;  3QSA A;  5EP8 A;  4IJ1 A;  1KGZ A;  4GA4 A;  1O17 A;  5EY3 A;  4X5E A; 
#chains in the Genus database with same CATH topology
 5GAE N;  4U67 J;  1N60 B;  3NVW C;  1SB3 A;  1KQS H;  1UOU A;  2W3S B;  3I56 H;  3CCV H;  4IOA J;  5H1S O;  4OWV A;  4X5C A;  5DM7 J;  3G71 H;  1YJN H;  3WNZ A;  1Q7Y J;  5HUL A;  2J0F A;  1VQ9 H;  4YEK A;  3C2E A;  1QPN A;  2ZJQ J;  4OWS A;  4IOC J;  1YI2 H;  1VQN H;  5BO3 A;  1Y69 K;  1N8R J;  3H5Q A;  5MLC O;  3CCL H;  1VQM H;  1QPQ A;  1QPR A;  4GKM A;  2QA4 H;  2B7P A;  5HUO A;  3VMM A;  4US8 A;  3CMA H;  4ZOK A;  1FFU B;  3TQV A;  3J7Z M;  1ZXY A;  1DGJ A;  2WK5 A;  4YYY A;  2WP4 A;  5C7S A;  3FC4 A;  3L4P A;  5HUP A;  3WO0 A;  5MPO C;  4WFB J;  1N63 B;  3CCE H;  4EAF A;  3WO1 A;  3CCM H;  1VQP H;  3QQS A;  1M90 J;  1VQ8 H;  1RRZ A;  1VQK H;  4X58 A;  1Q82 J;  1N62 B;  4ZOJ A;  4KWV A;  1VLB A;  4MUO A;  1YIT H;  2Q5W E;  2B7N A;  2OTL H;  1QPO A;  4X46 A;  4WFN J;  4WF9 J;  1O4U A;  4KWW A;  1VQU A;  3R6C A;  2W54 B;  1ZYK A;  1ZVW A;  4USA A;  3RPF A;  4ZTV A;  3C2F A;  1KHD A;  2I1O A;  3C2V A;  4YI7 A;  2QEX H;  3CCQ H;  3CF5 J;  1QVG H;  2QIE A;  1N61 B;  5DM6 J;  5BO2 A;  1YIJ H;  3CPW H;  4N5V A;  1JRO B;  1YTK A;  4GA5 A;  1AZY A;  3NRZ C;  3NVV C;  3TWP A;  1K8A J;  1VQ7 H;  5AYX A;  2ZJP J;  1OTP A;  5JVG J;  1JJ2 H;  1BRW A;  3QS8 A;  4I9A A;  4GA6 A;  1WYG A;  3C2R A;  4WFA J;  5JVH J;  3BII E;  3EUB 4;  3NS1 C;  3PAJ A;  5GAG N;  4GIU A;  4OWU A;  1QAP A;  5AN9 F;  3R88 A;  3CCU H;  1M1K J;  1VQL H;  3FAH A;  1FO4 A;  3PIO J;  2B7Q A;  4M0R A;  4AP8 A;  5C2L A;  3CCR H;  3CC7 H;  1KC8 J;  2OMD A;  5HL7 J;  1VQ4 H;  1YTD A;  2GVQ A;  3CCS H;  2W55 B;  4HKM A;  3AMZ A;  4N93 A;  2BPQ A;  1N5W B;  3SR6 C;  1RM6 A;  2ZJR J;  1FFV B;  3NVZ C;  1KD1 J;  1NVJ A;  2PA2 A;  2WK6 A;  1FM0 E;  3OW2 H;  3L0G A;  5GAH N;  3B9J C;  4EAD A;  1NJI J;  5BNE A;  4OWN A;  1WKI A;  5AYZ A;  3ETR C;  4WCE J;  5C1R A;  2ELC A;  4ZOH A;  4OWQ A;  3PIP J;  1VQ5 H;  1JRP B;  4C7Y A;  4UY8 M;  1FMA E;  1X1O A;  3I55 H;  3CC2 H;  4F3F C;  1VQ6 H;  2JBM A;  1Q86 J;  5BYT A;  1FIQ C;  1YHQ H;  2DSJ A;  5GAD N;  3C2O A;  4X5D A;  3AN1 A;  1S72 H;  3AM9 A;  2OTJ H;  1NVI E;  4X5A A;  1K73 J;  1RF8 B;  4OWM A;  4XR5 A;  1YTE A;  1Q81 J;  4LHM A;  2I14 A;  1K9M J;  1N5X A;  4N8Q A;  4X59 A;  3GNN A;  1YJW H;  1V8G A;  4ZOF A;  3G6E H;  1W2B H;  1YJ9 H;  3DLL J;  3CCJ H;  4US9 A;  3GBR A;  1GXB A;  3QR9 A;  2TPT A;  3CC4 H;  3CD6 H;  1QVF H;  3UU1 A;  4X5B A;  4IO9 J;  4GTN A;  4OWO A;  3QSA A;  2W3R B;  5AYY A;  5EP8 A;  4C7Z A;  4IJ1 A;  1KGZ A;  3NVY C;  3CXC H;  1ZXI B;  1SIJ A;  1V97 A;  4C80 A;  4GA4 A;  1O17 A;  1VDV A;  5EY3 A;  2E3T A;  1VQO H;  3CME H;  4X5E A;  3G4S H; 
#chains in the Genus database with same CATH homology
 1UOU A;  4OWV A;  4X5C A;  2J0F A;  4YEK A;  4OWS A;  5BO3 A;  3H5Q A;  4GKM A;  4ZOK A;  1ZXY A;  2WK5 A;  4YYY A;  5C7S A;  4EAF A;  3QQS A;  4X58 A;  4ZOJ A;  4MUO A;  4X46 A;  1VQU A;  3R6C A;  1ZYK A;  1ZVW A;  4ZTV A;  1KHD A;  4YI7 A;  5BO2 A;  4N5V A;  4GA5 A;  1AZY A;  3TWP A;  1OTP A;  1BRW A;  3QS8 A;  4GA6 A;  4GIU A;  4OWU A;  3R88 A;  4M0R A;  5C2L A;  2GVQ A;  4HKM A;  4N93 A;  2BPQ A;  2WK6 A;  4EAD A;  5BNE A;  4OWN A;  5C1R A;  2ELC A;  4OWQ A;  5BYT A;  2DSJ A;  4X5D A;  4X5A A;  4OWM A;  4XR5 A;  4LHM A;  4N8Q A;  4X59 A;  1V8G A;  4ZOF A;  3GBR A;  1GXB A;  3QR9 A;  2TPT A;  3UU1 A;  4X5B A;  4GTN A;  4OWO A;  3QSA A;  5EP8 A;  4IJ1 A;  1KGZ A;  4GA4 A;  1O17 A;  5EY3 A;  4X5E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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