4X46A

X-ray structure thymidine phosphorylase from salmonella typhimurium complex with so4 at 2.19 a
Total Genus 149
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
149
sequence length
440
structure length
440
Chain Sequence
MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLNLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGFDIFPDDNRFREIIQDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITGSILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGQLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPSDFVENYDKYLPTAMLSKAVYADTEGFISAMDTRALGMAVVSMGGGRRQASDTIDYSVGFTDMARLGDSIDGQRPLAVIHAKDEASWQEAAKAVKAAIILDDKAPASTPSVYRRITE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title X-RAY structure thymidine phosphorylase from Salmonella typhimurium complex with SO4 at 2.19 A
rcsb
molecule tags Transferase
source organism Salmonella enterica subsp. enterica serovar typhimurium
molecule keywords Thymidine phosphorylase
total genus 149
structure length 440
sequence length 440
chains with identical sequence B
ec nomenclature ec 2.4.2.4: Thymidine phosphorylase.
pdb deposition date 2014-12-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
A PF07831 PYNP_C Pyrimidine nucleoside phosphorylase C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 4x46A01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 4x46A02
3.90.1170.30 Alpha Beta Alpha-Beta Complex Aldehyde Oxidoreductase; domain 3 Pyrimidine nucleoside phosphorylase-like, C-terminal domain 4x46A03
4LHMA 2GVQA 4N5VA 1UOUA 1ZVWA 1O17A 2BPQA 4HKMA 4GA5A 5BNEA 4ZTVA 4YYYA 4GKMA 2WK6A 3QR9A 5BO2A 4ZOKA 3TWPA 2ELCA 1AZYA 3GBRA 2TPTA 4YEKA 1BRWA 3UU1A 4EADA 4OWVA 4N8QA 1ZYKA 1KHDA 1V8GA 4GA6A 1VQUA 4GIUA 3QSAA 4X46A 4XR5A 3R6CA 5C1RA 5EP8A 5BYTA 4X5BA 3QS8A 4EAFA 4ZOFA 4OWUA 4M0RA 4ZOJA 3H5QA 4X58A 4MUOA 1KGZA 4X5AA 2WK5A 1ZXYA 4OWNA 1OTPA 3QQSA 4OWSA 4N93A 5EY3A 4GA4A 4X5CA 5BO3A 4X5DA 4X59A 4GTNA 1GXBA 5C7SA 4YI7A 4IJ1A 2DSJA 4X5EA 3R88A 4OWOA 4OWMA 5C2LA 2J0FA 4OWQA
chains in the Genus database with same CATH superfamily
4C7ZA 4LHMA 1QPRA 2B7PA 1VQNH 3CCMH 3NVVC 3AN1A 5MLCO 3I56H 1M90J 1NVIE 3CC2H 1VQMH 2GVQA 4N5VA 1UOUA 3PIPJ 1ZVWA 1YITH 3CMAH 1K73J 1O17A 2BPQA 1QPOA 2E3TA 4HKMA 2OMDA 2QA4H 1Q81J 4GA5A 5BNEA 1NVJA 1N61B 4UY8M 1O4UA 3FAHA 4ZTVA 4YYYA 4KWWA 2QEXH 5HUPA 4IOCJ 4C7YA 4GKMA 1N5XA 2PA2A 2WK6A 4I9AA 3QR9A 5BO2A 3CCLH 4ZOKA 4USAA 3TWPA 2ELCA 3SR6C 1AZYA 1N63B 4WFNJ 5JVGJ 1S72H 3CD6H 3GNNA 5GAHN 4WF9J 4WFBJ 3CF5J 3GBRA 5GADN 4WCEJ 3CCVH 1YIJH 5DM7J 3CC4H 3BIIE 4US9A 1Y69K 1VQ6H 2TPTA 3CPWH 1FFVB 1WYGA 3FC4A 3RPFA 4YEKA 1BRWA 3CCUH 1VQ8H 3NVZC 1FO4A 1DGJA 3UU1A 3NS1C 4EADA 1VQPH 4OWVA 4C80A 1K8AJ 1QPQA 1FIQC 2W3RB 2ZJPJ 3WO1A 4N8QA 3I55H 1ZYKA 1JRPB 1FM0E 2Q5WE 2ZJQJ 3CCRH 1FMAE 1KHDA 1V8GA 4GA6A 3WNZA 1YJNH 3C2EA 3EUB4 3C2RA 1VQUA 4GIUA 1YJ9H 5JVHJ 2W55B 3QSAA 1M1KJ 3CCJH 4X46A 1Q7YJ 3PAJA 3J7ZM 1YTDA 2JBMA 4XR5A 1NJIJ 1RF8B 3AMZA 3L4PA 1YTEA 3TQVA 2W54B 5AYXA 3L0GA 3G71H 1VQ5H 1VQLH 3VMMA 1RRZA 3CCSH 5AN9F 1VQOH 4ZOHA 4U67J 3R6CA 5C1RA 5EP8A 5BYTA 1N60B 1Q86J 1VQKH 4X5BA 1QVFH 3DLLJ 5AYYA 3PIOJ 3QS8A 3ETRC 1WKIA 3CXCH 4EAFA 1N62B 1VLBA 3B9JC 1W2BH 1KQSH 1SB3A 3CMEH 5HULA 1VQ7H 1VDVA 3NVWC 4ZOFA 2I1OA 1YI2H 2W3SB 4OWUA 4AP8A 4M0RA 3CC7H 4ZOJA 3H5QA 1YHQH 4US8A 4X58A 1N5WB 3C2OA 3NVYC 4KWVA 1VQ9H 5GAEN 1JJ2H 4MUOA 5DM6J 4IO9J 1QPNA 5AYZA 1KC8J 5H1SO 5HL7J 3NRZC 1KGZA 4X5AA 1ZXIB 2WK5A 3AM9A 1V97A 1ZXYA 2B7QA 4OWNA 1OTPA 3QQSA 1KD1J 1VQ4H 1QVGH 4OWSA 1N8RJ 1QAPA 5GAGN 4N93A 2B7NA 2WP4A 1YJWH 5EY3A 3CCEH 2ZJRJ 4GA4A 4X5CA 4F3FC 5BO3A 4WFAJ 1FFUB 4X5DA 1JROB 3WO0A 4X59A 2OTLH 4GTNA 3C2VA 2QIEA 1GXBA 5C7SA 1RM6A 1YTKA 4YI7A 2I14A 3C2FA 3G6EH 3G4SH 5HUOA 4IJ1A 5MPOC 2DSJA 3OW2H 3CCQH 1Q82J 4IOAJ 4X5EA 3R88A 4OWOA 1SIJA 2OTJH 4OWMA 5C2LA 2J0FA 1X1OA 1K9MJ 4OWQA
chains in the Genus database with same CATH topology
4LHMA 2GVQA 4N5VA 1UOUA 1ZVWA 1O17A 2BPQA 4HKMA 4GA5A 5BNEA 4ZTVA 4YYYA 4GKMA 2WK6A 3QR9A 5BO2A 4ZOKA 3TWPA 2ELCA 1AZYA 3GBRA 2TPTA 4YEKA 1BRWA 3UU1A 4EADA 4OWVA 4N8QA 1ZYKA 1KHDA 1V8GA 4GA6A 1VQUA 4GIUA 3QSAA 4X46A 4XR5A 3R6CA 5C1RA 5EP8A 5BYTA 4X5BA 3QS8A 4EAFA 4ZOFA 4OWUA 4M0RA 4ZOJA 3H5QA 4X58A 4MUOA 1KGZA 4X5AA 2WK5A 1ZXYA 4OWNA 1OTPA 3QQSA 4OWSA 4N93A 5EY3A 4GA4A 4X5CA 5BO3A 4X5DA 4X59A 4GTNA 1GXBA 5C7SA 4YI7A 4IJ1A 2DSJA 4X5EA 3R88A 4OWOA 4OWMA 5C2LA 2J0FA 4OWQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LHM A;  2GVQ A;  4N5V A;  1UOU A;  1ZVW A;  1O17 A;  2BPQ A;  4HKM A;  4GA5 A;  5BNE A;  4ZTV A;  4YYY A;  4GKM A;  2WK6 A;  3QR9 A;  5BO2 A;  4ZOK A;  3TWP A;  2ELC A;  1AZY A;  3GBR A;  2TPT A;  4YEK A;  1BRW A;  3UU1 A;  4EAD A;  4OWV A;  4N8Q A;  1ZYK A;  1KHD A;  1V8G A;  4GA6 A;  1VQU A;  4GIU A;  3QSA A;  4X46 A;  4XR5 A;  3R6C A;  5C1R A;  5EP8 A;  5BYT A;  4X5B A;  3QS8 A;  4EAF A;  4ZOF A;  4OWU A;  4M0R A;  4ZOJ A;  3H5Q A;  4X58 A;  4MUO A;  1KGZ A;  4X5A A;  2WK5 A;  1ZXY A;  4OWN A;  1OTP A;  3QQS A;  4OWS A;  4N93 A;  5EY3 A;  4GA4 A;  4X5C A;  5BO3 A;  4X5D A;  4X59 A;  4GTN A;  1GXB A;  5C7S A;  4YI7 A;  4IJ1 A;  2DSJ A;  4X5E A;  3R88 A;  4OWO A;  4OWM A;  5C2L A;  2J0F A;  4OWQ A; 
#chains in the Genus database with same CATH topology
 4C7Z A;  4LHM A;  1QPR A;  2B7P A;  1VQN H;  3CCM H;  3NVV C;  3AN1 A;  5MLC O;  3I56 H;  1M90 J;  1NVI E;  3CC2 H;  1VQM H;  2GVQ A;  4N5V A;  1UOU A;  3PIP J;  1ZVW A;  1YIT H;  3CMA H;  1K73 J;  1O17 A;  2BPQ A;  1QPO A;  2E3T A;  4HKM A;  2OMD A;  2QA4 H;  1Q81 J;  4GA5 A;  5BNE A;  1NVJ A;  1N61 B;  4UY8 M;  1O4U A;  3FAH A;  4ZTV A;  4YYY A;  4KWW A;  2QEX H;  5HUP A;  4IOC J;  4C7Y A;  4GKM A;  1N5X A;  2PA2 A;  2WK6 A;  4I9A A;  3QR9 A;  5BO2 A;  3CCL H;  4ZOK A;  4USA A;  3TWP A;  2ELC A;  3SR6 C;  1AZY A;  1N63 B;  4WFN J;  5JVG J;  1S72 H;  3CD6 H;  3GNN A;  5GAH N;  4WF9 J;  4WFB J;  3CF5 J;  3GBR A;  5GAD N;  4WCE J;  3CCV H;  1YIJ H;  5DM7 J;  3CC4 H;  3BII E;  4US9 A;  1Y69 K;  1VQ6 H;  2TPT A;  3CPW H;  1FFV B;  1WYG A;  3FC4 A;  3RPF A;  4YEK A;  1BRW A;  3CCU H;  1VQ8 H;  3NVZ C;  1FO4 A;  1DGJ A;  3UU1 A;  3NS1 C;  4EAD A;  1VQP H;  4OWV A;  4C80 A;  1K8A J;  1QPQ A;  1FIQ C;  2W3R B;  2ZJP J;  3WO1 A;  4N8Q A;  3I55 H;  1ZYK A;  1JRP B;  1FM0 E;  2Q5W E;  2ZJQ J;  3CCR H;  1FMA E;  1KHD A;  1V8G A;  4GA6 A;  3WNZ A;  1YJN H;  3C2E A;  3EUB 4;  3C2R A;  1VQU A;  4GIU A;  1YJ9 H;  5JVH J;  2W55 B;  3QSA A;  1M1K J;  3CCJ H;  4X46 A;  1Q7Y J;  3PAJ A;  3J7Z M;  1YTD A;  2JBM A;  4XR5 A;  1NJI J;  1RF8 B;  3AMZ A;  3L4P A;  1YTE A;  3TQV A;  2W54 B;  5AYX A;  3L0G A;  3G71 H;  1VQ5 H;  1VQL H;  3VMM A;  1RRZ A;  3CCS H;  5AN9 F;  1VQO H;  4ZOH A;  4U67 J;  3R6C A;  5C1R A;  5EP8 A;  5BYT A;  1N60 B;  1Q86 J;  1VQK H;  4X5B A;  1QVF H;  3DLL J;  5AYY A;  3PIO J;  3QS8 A;  3ETR C;  1WKI A;  3CXC H;  4EAF A;  1N62 B;  1VLB A;  3B9J C;  1W2B H;  1KQS H;  1SB3 A;  3CME H;  5HUL A;  1VQ7 H;  1VDV A;  3NVW C;  4ZOF A;  2I1O A;  1YI2 H;  2W3S B;  4OWU A;  4AP8 A;  4M0R A;  3CC7 H;  4ZOJ A;  3H5Q A;  1YHQ H;  4US8 A;  4X58 A;  1N5W B;  3C2O A;  3NVY C;  4KWV A;  1VQ9 H;  5GAE N;  1JJ2 H;  4MUO A;  5DM6 J;  4IO9 J;  1QPN A;  5AYZ A;  1KC8 J;  5H1S O;  5HL7 J;  3NRZ C;  1KGZ A;  4X5A A;  1ZXI B;  2WK5 A;  3AM9 A;  1V97 A;  1ZXY A;  2B7Q A;  4OWN A;  1OTP A;  3QQS A;  1KD1 J;  1VQ4 H;  1QVG H;  4OWS A;  1N8R J;  1QAP A;  5GAG N;  4N93 A;  2B7N A;  2WP4 A;  1YJW H;  5EY3 A;  3CCE H;  2ZJR J;  4GA4 A;  4X5C A;  4F3F C;  5BO3 A;  4WFA J;  1FFU B;  4X5D A;  1JRO B;  3WO0 A;  4X59 A;  2OTL H;  4GTN A;  3C2V A;  2QIE A;  1GXB A;  5C7S A;  1RM6 A;  1YTK A;  4YI7 A;  2I14 A;  3C2F A;  3G6E H;  3G4S H;  5HUO A;  4IJ1 A;  5MPO C;  2DSJ A;  3OW2 H;  3CCQ H;  1Q82 J;  4IOA J;  4X5E A;  3R88 A;  4OWO A;  1SIJ A;  2OTJ H;  4OWM A;  5C2L A;  2J0F A;  1X1O A;  1K9M J;  4OWQ A; 
#chains in the Genus database with same CATH homology
 4LHM A;  2GVQ A;  4N5V A;  1UOU A;  1ZVW A;  1O17 A;  2BPQ A;  4HKM A;  4GA5 A;  5BNE A;  4ZTV A;  4YYY A;  4GKM A;  2WK6 A;  3QR9 A;  5BO2 A;  4ZOK A;  3TWP A;  2ELC A;  1AZY A;  3GBR A;  2TPT A;  4YEK A;  1BRW A;  3UU1 A;  4EAD A;  4OWV A;  4N8Q A;  1ZYK A;  1KHD A;  1V8G A;  4GA6 A;  1VQU A;  4GIU A;  3QSA A;  4X46 A;  4XR5 A;  3R6C A;  5C1R A;  5EP8 A;  5BYT A;  4X5B A;  3QS8 A;  4EAF A;  4ZOF A;  4OWU A;  4M0R A;  4ZOJ A;  3H5Q A;  4X58 A;  4MUO A;  1KGZ A;  4X5A A;  2WK5 A;  1ZXY A;  4OWN A;  1OTP A;  3QQS A;  4OWS A;  4N93 A;  5EY3 A;  4GA4 A;  4X5C A;  5BO3 A;  4X5D A;  4X59 A;  4GTN A;  1GXB A;  5C7S A;  4YI7 A;  4IJ1 A;  2DSJ A;  4X5E A;  3R88 A;  4OWO A;  4OWM A;  5C2L A;  2J0F A;  4OWQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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