1I6VD

Thermus aquaticus core rna polymerase-rifampicin complex
Total Genus 181
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
181
sequence length
1234
structure length
1174
Chain Sequence
KEVRKVRIALASPEKIRSWSYGEVEKPETEAKVCERCAVEVTRSIVRRYRMAHIELATPAAHIWFVKDVPSKIATLLDLSATELEQVLYFNKYIVLDPKAAVLDAVPVEKRQLLTDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIDARMGAEAIQELLKELDLEKLERELLEEMKHPSRARRAKARKRLEVVRAFLDSGNRPEWMILEAVPVLPPDATSDLNDLYRRLINRNNRLKKLLAQGAPEIIIRNEKRMLQEAVDAVIDNGRRGSPVTNPGSERPLRSLTDILSGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKRMALELFKPFLLKKMEEKAFAPNVKAARRMLERQRDIKDEVWDALEEVIHGKVVLLNRAPTLHRLGIQAFQPVLVEGQSIQLHPLVCEAFNADFDGDQMAVHVPLSSFAQAEARIQMLSAHNLLSPASGEPLAKPSRDIILGLYYITQVRKEKKGAGMAFATPEEALAAYERGEVALNAPIVVAGRETSVGRLKFVFANPDEALLAVAHGLLDLQDTVTTRYLGRRLETSPGRILFARIVGEAVGDEKVAQELIQMDVPQEKNSLKDLVYQAFLRLGMEKTARLLDALKYYGFTLSTTSGITIGIDDAVIPEEKQRYLEEADRKLRQIEQAYEMGFLTDRERYDQVIQLWTETTEKVTQAVFNNFEENYPFNPLYVMAQSGARGNPQQIRQLCGMRGLMQKPSGETFEVPVRSSFREGLTVLEYFISSHGARKGGADTALRTADSGYLTRKLVDVAHEIVVREADCGTTNYISVPLFQMDEVTRTLRLRKRSDIESGLYGRVLAREVEALGRRLEEGRYLSLEDVHFLIKAAEAGEVREVPVRSPLTCQTRYGVCQKCYGYDLSMARPVSIGEAVGVVAAESIGEPGTQLTMRTGTDITQGLPRVIELFEARRPKAKAVISEIDGVVRIEEGEDRLSVFVESEGFSKEYKLPKDARLLVKDGDYVEAGQPLTRGAIDPHQLLEAKGPEAVERYLVDEIQKVYRAQGVKLHDKHIEIVVRQMLKYVEVTDPGDSRLLEGQVLEKWDVEALNERLIAVPVAWKPLLMGVTKSALSTKSWLSAASFQNTTHVLTEAAIAGKKDELIGLKENVILGRLIPAGTGSDFVRFTQVVDQRTLKAIE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural mechanism for rifampicin inhibition of bacterial rna polymerase.
pubmed doi rcsb
molecule tags Transcription
molecule keywords DNA-DIRECTED RNA POLYMERASE
total genus 181
structure length 1174
sequence length 1234
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2001-03-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF00623 RNA_pol_Rpb1_2 RNA polymerase Rpb1, domain 2
D PF04983 RNA_pol_Rpb1_3 RNA polymerase Rpb1, domain 3
D PF04998 RNA_pol_Rpb1_5 RNA polymerase Rpb1, domain 5
D PF05000 RNA_pol_Rpb1_4 RNA polymerase Rpb1, domain 4
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.132.30 Mainly Alpha Orthogonal Bundle Topoisomerase I; Chain A, domain 4 Topoisomerase I; Chain A, domain 4 1i6vD03
1.10.274.100 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Enzyme I; Chain A, domain 2 1i6vD02
3.90.105.30 Alpha Beta Alpha-Beta Complex Molybdopterin biosynthesis moea protein, domain 2 Molybdopterin biosynthesis moea protein, domain 2 1i6vD05
2NVYA 2BE5D 2A6HD 3CQZA 4C2MA 2E2IA 1R9TA 2R92A 1HQMD 2E2HA 1TWFA 1TWHA 1YNJD 1SFOA 3FKIA 2PMZA 2O5JD 1ZYRD 2JA5A 1Y1WA 3GTQA 1TWCA 2R7ZA 2JA6A 1WCMA 1I3QA 1I50A 3GTKA 2Y0SA 1Y1VA 3GTLA 3GTOA 2R93A 1TWGA 2A69D 3HKZA 4QIWA 3GTPA 2JA7A 2A68D 3H0GA 2B63A 2WAQA 3GTMA 2WB1A 1SMYD 2VUMA 1I6VD 1IW7D 2CW0D 1TWAA 4AYBA 2YU9A 3GTGA 2NVXA 1YNND 1K83A 2A6ED 3GTJA
chains in the Genus database with same CATH superfamily
1G8RA 3K57A 5D8HB 4FYDA 2HWGA 1K4TA 3EZEA 4CEJA 2R4GA 1A36A 1WQHA 4BAAA 4NOMA 2LPJA 4EJ3A 4D3ZA 1TL8A 3DU5A 2JA6A 2N1DB 3LR8A 1TWCA 2LYIA 4Q5VA 3GTKA 4C6GA 4IP9A 2LKMB 2NRPA 3LR2A 3GTLA 2R93A 2NQVA 5IZ2A 4NWBA 1Y2MA 4FGUA 5ERVA 3GTPA 2B63A 2NQNA 3GTMA 2FIPA 1IW7D 3LF9A 2NRSA 4D3YA 1TGOA 3GTGA 2HROA 4NOKA 2FTSA 5ERQA 1R5ZA 3JSYA 5ERRA 5G2RA 1SEUA 4O26A 4AHCA 3EZAA 4KC6A 2EZCA 2JA5A 2R7ZA 1I3QA 4U90A 1RR8C 2Y0SA 2NQUA 1WU2A 2LTHA 3EZBA 3K5NA 1TWGA 1WQGA 2A69D 3HKZA 4LMOA 2FIOA 2N3EA 5D6GA 1R49A 1A31A 1W27A 1WQFA 2A68D 1MIUA 1T6JA 2WAQA 2NQSA 2WB1A 2VUMA 2CW0D 4PD0A 4H3TA 1RRJA 4FXDA 3LRDA 4PD1A 4TK4A 2YIIA 4AYBA 1EH1A 4BABA 1Y698 1YNND 1K83A 3SJRA 2A6ED 1R9TA 5MLC9 3GTJA 2NVYA 2X0QA 4CEHA 3K59A 2NQMA 5ERTA 2BE5D 4C2MA 4KAWX 1EJ9A 2E2IA 2MX9A 1A35A 2R92A 1HQMD 3MAQA 1GE9A 4CQ5A 2X0PA 1DD5A 1T3EA 1TWHA 1YNJD 1SFOA 2K3OA 2X0OA 4U91A 5JSBB 2O5JD 2F4QA 1Y1WA 5ERSA 1EZAA 1I50A 3M4AA 4KB2A 3U44A 4KDDA 4IP8A 1T6PA 4F3EA 1NH3A 4QIWA 2K3QA 2MX8A 4V2QA 2JA7A 1V9MA 1Q8IA 1I6VD 4C5RA 1TWAA 4TK1A 1SC7A 4GFQA 5G2SA 2YU9A 3WVOA 3U4QA 1UZ5A 3K5LA 2NQRA 4QCLA 4KB4A 1T8IA 3NZ4A 3K5MA 2A6HD 3CQZA 2LPIA 1LPQA 1IS1A 1XI8A 2FU3A 2Y0NA 2E2HA 4FBSA 1TWFA 4OYDB 2NROA 4L8IA 2AQLA 3IAYA 2EZBA 3FKIA 2PMZA 2NQQA 1ZYRD 4C5SA 4NOLA 3GTQA 3K58A 1WCMA 1EZBA 2X3LA 5C9HA 2F5JA 2B9SB 2MQAA 1Y1VA 4AN8A 3GTOA 4CEIA 1G8LA 4V2RA 3P9AA 1K4SA 1ZYMA 3DU6A 2K3NA 5CQGA 3KYLA 5ERUA 2EZAA 2MP0A 3H0GA 4C5UA 1ISEA 1SMYD 4TK3A 4Q5GA 2NQKA 4JLRC 3LR6A 1EK8A 2VK9A 3LHPS 2NVXA 5JSNB 3K5OA 1FC5A
chains in the Genus database with same CATH topology
1G8RA 3K57A 5D8HB 4FYDA 1K4TA 4CEJA 2R4GA 1A36A 1WQHA 4NOMA 2LPJA 4EJ3A 4D3ZA 1TL8A 3DU5A 2JA6A 2N1DB 3LR8A 1TWCA 2LYIA 4Q5VA 3GTKA 4IP9A 2LKMB 2NRPA 3LR2A 3GTLA 2R93A 2NQVA 5IZ2A 4NWBA 4FGUA 5ERVA 3GTPA 2B63A 2NQNA 3GTMA 2FIPA 1IW7D 3LF9A 2NRSA 4D3YA 1TGOA 3GTGA 4NOKA 2FTSA 5ERQA 1R5ZA 3JSYA 5ERRA 5G2RA 1SEUA 4O26A 4AHCA 4KC6A 2JA5A 2R7ZA 1I3QA 4U90A 1RR8C 2Y0SA 2NQUA 1WU2A 2LTHA 3K5NA 1TWGA 1WQGA 2A69D 3HKZA 4LMOA 2FIOA 2N3EA 5D6GA 1R49A 1A31A 1WQFA 2A68D 1MIUA 2WAQA 2NQSA 2WB1A 2VUMA 2CW0D 4PD0A 4H3TA 1RRJA 4FXDA 3LRDA 4PD1A 4TK4A 4AYBA 1EH1A 1Y698 1YNND 1K83A 3SJRA 2A6ED 1R9TA 5MLC9 3GTJA 2NVYA 2X0QA 4CEHA 3K59A 2NQMA 5ERTA 2BE5D 4C2MA 4KAWX 1EJ9A 2E2IA 2MX9A 1A35A 2R92A 1HQMD 3MAQA 1GE9A 2X0PA 1DD5A 1T3EA 1TWHA 1YNJD 1SFOA 2K3OA 2X0OA 4U91A 5JSBB 2O5JD 2F4QA 1Y1WA 5ERSA 1I50A 3M4AA 4KB2A 3U44A 4KDDA 4IP8A 4F3EA 1NH3A 4QIWA 2K3QA 2MX8A 2JA7A 1V9MA 1Q8IA 1I6VD 1TWAA 4TK1A 1SC7A 4GFQA 5G2SA 2YU9A 3WVOA 3U4QA 1UZ5A 3K5LA 2NQRA 4QCLA 4KB4A 1T8IA 3K5MA 2A6HD 3CQZA 2LPIA 1LPQA 1IS1A 1XI8A 2FU3A 2Y0NA 2E2HA 4FBSA 1TWFA 4OYDB 2NROA 4L8IA 2AQLA 3IAYA 3FKIA 2PMZA 2NQQA 1ZYRD 4NOLA 3GTQA 3K58A 1WCMA 2X3LA 5C9HA 2F5JA 2B9SB 2MQAA 1Y1VA 4AN8A 3GTOA 4CEIA 1G8LA 3P9AA 1K4SA 2K3NA 3DU6A 5ERUA 5CQGA 3KYLA 3H0GA 1ISEA 1SMYD 4TK3A 4Q5GA 2NQKA 4JLRC 3LR6A 1EK8A 2VK9A 3LHPS 2NVXA 5JSNB 3K5OA 1FC5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NVY A;  2BE5 D;  2A6H D;  3CQZ A;  4C2M A;  2E2I A;  1R9T A;  2R92 A;  1HQM D;  2E2H A;  1TWF A;  1TWH A;  1YNJ D;  1SFO A;  3FKI A;  2PMZ A;  2O5J D;  1ZYR D;  2JA5 A;  1Y1W A;  3GTQ A;  1TWC A;  2R7Z A;  2JA6 A;  1WCM A;  1I3Q A;  1I50 A;  3GTK A;  2Y0S A;  1Y1V A;  3GTL A;  3GTO A;  2R93 A;  1TWG A;  2A69 D;  3HKZ A;  4QIW A;  3GTP A;  2JA7 A;  2A68 D;  3H0G A;  2B63 A;  2WAQ A;  3GTM A;  2WB1 A;  1SMY D;  2VUM A;  1I6V D;  1IW7 D;  2CW0 D;  1TWA A;  4AYB A;  2YU9 A;  3GTG A;  2NVX A;  1YNN D;  1K83 A;  2A6E D;  3GTJ A; 
#chains in the Genus database with same CATH topology
 1G8R A;  3K57 A;  5D8H B;  4FYD A;  2HWG A;  1K4T A;  3EZE A;  4CEJ A;  2R4G A;  1A36 A;  1WQH A;  4BAA A;  4NOM A;  2LPJ A;  4EJ3 A;  4D3Z A;  1TL8 A;  3DU5 A;  2JA6 A;  2N1D B;  3LR8 A;  1TWC A;  2LYI A;  4Q5V A;  3GTK A;  4C6G A;  4IP9 A;  2LKM B;  2NRP A;  3LR2 A;  3GTL A;  2R93 A;  2NQV A;  5IZ2 A;  4NWB A;  1Y2M A;  4FGU A;  5ERV A;  3GTP A;  2B63 A;  2NQN A;  3GTM A;  2FIP A;  1IW7 D;  3LF9 A;  2NRS A;  4D3Y A;  1TGO A;  3GTG A;  2HRO A;  4NOK A;  2FTS A;  5ERQ A;  1R5Z A;  3JSY A;  5ERR A;  5G2R A;  1SEU A;  4O26 A;  4AHC A;  3EZA A;  4KC6 A;  2EZC A;  2JA5 A;  2R7Z A;  1I3Q A;  4U90 A;  1RR8 C;  2Y0S A;  2NQU A;  1WU2 A;  2LTH A;  3EZB A;  3K5N A;  1TWG A;  1WQG A;  2A69 D;  3HKZ A;  4LMO A;  2FIO A;  2N3E A;  5D6G A;  1R49 A;  1A31 A;  1W27 A;  1WQF A;  2A68 D;  1MIU A;  1T6J A;  2WAQ A;  2NQS A;  2WB1 A;  2VUM A;  2CW0 D;  4PD0 A;  4H3T A;  1RRJ A;  4FXD A;  3LRD A;  4PD1 A;  4TK4 A;  2YII A;  4AYB A;  1EH1 A;  4BAB A;  1Y69 8;  1YNN D;  1K83 A;  3SJR A;  2A6E D;  1R9T A;  5MLC 9;  3GTJ A;  2NVY A;  2X0Q A;  4CEH A;  3K59 A;  2NQM A;  5ERT A;  2BE5 D;  4C2M A;  4KAW X;  1EJ9 A;  2E2I A;  2MX9 A;  1A35 A;  2R92 A;  1HQM D;  3MAQ A;  1GE9 A;  4CQ5 A;  2X0P A;  1DD5 A;  1T3E A;  1TWH A;  1YNJ D;  1SFO A;  2K3O A;  2X0O A;  4U91 A;  5JSB B;  2O5J D;  2F4Q A;  1Y1W A;  5ERS A;  1EZA A;  1I50 A;  3M4A A;  4KB2 A;  3U44 A;  4KDD A;  4IP8 A;  1T6P A;  4F3E A;  1NH3 A;  4QIW A;  2K3Q A;  2MX8 A;  4V2Q A;  2JA7 A;  1V9M A;  1Q8I A;  1I6V D;  4C5R A;  1TWA A;  4TK1 A;  1SC7 A;  4GFQ A;  5G2S A;  2YU9 A;  3WVO A;  3U4Q A;  1UZ5 A;  3K5L A;  2NQR A;  4QCL A;  4KB4 A;  1T8I A;  3NZ4 A;  3K5M A;  2A6H D;  3CQZ A;  2LPI A;  1LPQ A;  1IS1 A;  1XI8 A;  2FU3 A;  2Y0N A;  2E2H A;  4FBS A;  1TWF A;  4OYD B;  2NRO A;  4L8I A;  2AQL A;  3IAY A;  2EZB A;  3FKI A;  2PMZ A;  2NQQ A;  1ZYR D;  4C5S A;  4NOL A;  3GTQ A;  3K58 A;  1WCM A;  1EZB A;  2X3L A;  5C9H A;  2F5J A;  2B9S B;  2MQA A;  1Y1V A;  4AN8 A;  3GTO A;  4CEI A;  1G8L A;  4V2R A;  3P9A A;  1K4S A;  1ZYM A;  3DU6 A;  2K3N A;  5CQG A;  3KYL A;  5ERU A;  2EZA A;  2MP0 A;  3H0G A;  4C5U A;  1ISE A;  1SMY D;  4TK3 A;  4Q5G A;  2NQK A;  4JLR C;  3LR6 A;  1EK8 A;  2VK9 A;  3LHP S;  2NVX A;  5JSN B;  3K5O A;  1FC5 A; 
#chains in the Genus database with same CATH homology
 1G8R A;  3K57 A;  5D8H B;  4FYD A;  1K4T A;  4CEJ A;  2R4G A;  1A36 A;  1WQH A;  4NOM A;  2LPJ A;  4EJ3 A;  4D3Z A;  1TL8 A;  3DU5 A;  2JA6 A;  2N1D B;  3LR8 A;  1TWC A;  2LYI A;  4Q5V A;  3GTK A;  4IP9 A;  2LKM B;  2NRP A;  3LR2 A;  3GTL A;  2R93 A;  2NQV A;  5IZ2 A;  4NWB A;  4FGU A;  5ERV A;  3GTP A;  2B63 A;  2NQN A;  3GTM A;  2FIP A;  1IW7 D;  3LF9 A;  2NRS A;  4D3Y A;  1TGO A;  3GTG A;  4NOK A;  2FTS A;  5ERQ A;  1R5Z A;  3JSY A;  5ERR A;  5G2R A;  1SEU A;  4O26 A;  4AHC A;  4KC6 A;  2JA5 A;  2R7Z A;  1I3Q A;  4U90 A;  1RR8 C;  2Y0S A;  2NQU A;  1WU2 A;  2LTH A;  3K5N A;  1TWG A;  1WQG A;  2A69 D;  3HKZ A;  4LMO A;  2FIO A;  2N3E A;  5D6G A;  1R49 A;  1A31 A;  1WQF A;  2A68 D;  1MIU A;  2WAQ A;  2NQS A;  2WB1 A;  2VUM A;  2CW0 D;  4PD0 A;  4H3T A;  1RRJ A;  4FXD A;  3LRD A;  4PD1 A;  4TK4 A;  4AYB A;  1EH1 A;  1Y69 8;  1YNN D;  1K83 A;  3SJR A;  2A6E D;  1R9T A;  5MLC 9;  3GTJ A;  2NVY A;  2X0Q A;  4CEH A;  3K59 A;  2NQM A;  5ERT A;  2BE5 D;  4C2M A;  4KAW X;  1EJ9 A;  2E2I A;  2MX9 A;  1A35 A;  2R92 A;  1HQM D;  3MAQ A;  1GE9 A;  2X0P A;  1DD5 A;  1T3E A;  1TWH A;  1YNJ D;  1SFO A;  2K3O A;  2X0O A;  4U91 A;  5JSB B;  2O5J D;  2F4Q A;  1Y1W A;  5ERS A;  1I50 A;  3M4A A;  4KB2 A;  3U44 A;  4KDD A;  4IP8 A;  4F3E A;  1NH3 A;  4QIW A;  2K3Q A;  2MX8 A;  2JA7 A;  1V9M A;  1Q8I A;  1I6V D;  1TWA A;  4TK1 A;  1SC7 A;  4GFQ A;  5G2S A;  2YU9 A;  3WVO A;  3U4Q A;  1UZ5 A;  3K5L A;  2NQR A;  4QCL A;  4KB4 A;  1T8I A;  3K5M A;  2A6H D;  3CQZ A;  2LPI A;  1LPQ A;  1IS1 A;  1XI8 A;  2FU3 A;  2Y0N A;  2E2H A;  4FBS A;  1TWF A;  4OYD B;  2NRO A;  4L8I A;  2AQL A;  3IAY A;  3FKI A;  2PMZ A;  2NQQ A;  1ZYR D;  4NOL A;  3GTQ A;  3K58 A;  1WCM A;  2X3L A;  5C9H A;  2F5J A;  2B9S B;  2MQA A;  1Y1V A;  4AN8 A;  3GTO A;  4CEI A;  1G8L A;  3P9A A;  1K4S A;  2K3N A;  3DU6 A;  5ERU A;  5CQG A;  3KYL A;  3H0G A;  1ISE A;  1SMY D;  4TK3 A;  4Q5G A;  2NQK A;  4JLR C;  3LR6 A;  1EK8 A;  2VK9 A;  3LHP S;  2NVX A;  5JSN B;  3K5O A;  1FC5 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...