The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
181
|
sequence length |
1234
|
structure length |
1174
|
Chain Sequence |
KEVRKVRIALASPEKIRSWSYGEVEKPETEAKVCERCAVEVTRSIVRRYRMAHIELATPAAHIWFVKDVPSKIATLLDLSATELEQVLYFNKYIVLDPKAAVLDAVPVEKRQLLTDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIDARMGAEAIQELLKELDLEKLERELLEEMKHPSRARRAKARKRLEVVRAFLDSGNRPEWMILEAVPVLPPDATSDLNDLYRRLINRNNRLKKLLAQGAPEIIIRNEKRMLQEAVDAVIDNGRRGSPVTNPGSERPLRSLTDILSGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKRMALELFKPFLLKKMEEKAFAPNVKAARRMLERQRDIKDEVWDALEEVIHGKVVLLNRAPTLHRLGIQAFQPVLVEGQSIQLHPLVCEAFNADFDGDQMAVHVPLSSFAQAEARIQMLSAHNLLSPASGEPLAKPSRDIILGLYYITQVRKEKKGAGMAFATPEEALAAYERGEVALNAPIVVAGRETSVGRLKFVFANPDEALLAVAHGLLDLQDTVTTRYLGRRLETSPGRILFARIVGEAVGDEKVAQELIQMDVPQEKNSLKDLVYQAFLRLGMEKTARLLDALKYYGFTLSTTSGITIGIDDAVIPEEKQRYLEEADRKLRQIEQAYEMGFLTDRERYDQVIQLWTETTEKVTQAVFNNFEENYPFNPLYVMAQSGARGNPQQIRQLCGMRGLMQKPSGETFEVPVRSSFREGLTVLEYFISSHGARKGGADTALRTADSGYLTRKLVDVAHEIVVREADCGTTNYISVPLFQMDEVTRTLRLRKRSDIESGLYGRVLAREVEALGRRLEEGRYLSLEDVHFLIKAAEAGEVREVPVRSPLTCQTRYGVCQKCYGYDLSMARPVSIGEAVGVVAAESIGEPGTQLTMRTGTDITQGLPRVIELFEARRPKAKAVISEIDGVVRIEEGEDRLSVFVESEGFSKEYKLPKDARLLVKDGDYVEAGQPLTRGAIDPHQLLEAKGPEAVERYLVDEIQKVYRAQGVKLHDKHIEIVVRQMLKYVEVTDPGDSRLLEGQVLEKWDVEALNERLIAVPVAWKPLLMGVTKSALSTKSWLSAASFQNTTHVLTEAAIAGKKDELIGLKENVILGRLIPAGTGSDFVRFTQVVDQRTLKAIE
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Structural mechanism for rifampicin inhibition of bacterial rna polymerase.
pubmed doi rcsb |
| molecule keywords |
DNA-DIRECTED RNA POLYMERASE
|
| molecule tags |
Transcription
|
| total genus |
181
|
| structure length |
1174
|
| sequence length |
1234
|
| ec nomenclature |
ec
2.7.7.6: DNA-directed RNA polymerase. |
| pdb deposition date | 2001-03-05 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| D | PF00623 | RNA_pol_Rpb1_2 | RNA polymerase Rpb1, domain 2 |
| D | PF04983 | RNA_pol_Rpb1_3 | RNA polymerase Rpb1, domain 3 |
| D | PF04998 | RNA_pol_Rpb1_5 | RNA polymerase Rpb1, domain 5 |
| D | PF05000 | RNA_pol_Rpb1_4 | RNA polymerase Rpb1, domain 4 |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Orthogonal Bundle | Topoisomerase I; Chain A, domain 4 | Topoisomerase I; Chain A, domain 4 | ||
| Mainly Alpha | Orthogonal Bundle | Enzyme I; Chain A, domain 2 | Enzyme I; Chain A, domain 2 | ||
| Alpha Beta | Alpha-Beta Complex | Molybdopterin biosynthesis moea protein, domain 2 | Molybdopterin biosynthesis moea protein, domain 2 |
#chains in the Genus database with same CATH superfamily 4QIW A; 1ZYR D; 2YU9 A; 2JA5 A; 1SMY D; 1IW7 D; 1TWH A; 2A6E D; 1TWA A; 3GTO A; 2Y0S A; 2JA6 A; 2WAQ A; 3GTM A; 3GTP A; 1Y1W A; 3CQZ A; 1I3Q A; 1I50 A; 2E2H A; 3H0G A; 4AYB A; 3FKI A; 2E2I A; 2NVY A; 2PMZ A; 1R9T A; 1Y1V A; 1TWF A; 3GTL A; 1TWC A; 2A69 D; 2R92 A; 2CW0 D; 2B63 A; 3GTG A; 1HQM D; 2A68 D; 2WB1 A; 2VUM A; 1YNJ D; 3GTQ A; 2R93 A; 2A6H D; 3HKZ A; 2O5J D; 3GTK A; 4C2M A; 2R7Z A; 1K83 A; 2JA7 A; 1YNN D; 1I6V D; 2NVX A; 1SFO A; 1TWG A; 2BE5 D; 3GTJ A; 1WCM A; #chains in the Genus database with same CATH topology 4QIW A; 4D3Z A; 2YU9 A; 3LHP S; 1IW7 D; 5G2R A; 1TWA A; 3GTO A; 5G2S A; 2Y0S A; 1ISE A; 4FBS A; 1FC5 A; 2NQS A; 4EJ3 A; 1IS1 A; 4TK4 A; 4OYD B; 3IAY A; 4AYB A; 4IP8 A; 1W27 A; 1XI8 A; 1EZA A; 2HRO A; 3K5N A; 5CQG A; 1GE9 A; 2FIP A; 2LTH A; 3NZ4 A; 3K5O A; 3JSY A; 4NWB A; 3GTL A; 1TWC A; 2YII A; 4QCL A; 1WU2 A; 4CEJ A; 1TL8 A; 1A31 A; 3K5M A; 1EZB A; 2R93 A; 3GTQ A; 2EZB A; 2NQK A; 4BAA A; 5IZ2 A; 2B9S B; 3GTK A; 4C6G A; 2NQR A; 1YNN D; 1G8R A; 2K3Q A; 5ERS A; 5ERT A; 1I6V D; 3SJR A; 2HWG A; 3GTJ A; 1WCM A; 4Q5G A; 1EK8 A; 2N3E A; 1R49 A; 1SC7 A; 1SMY D; 2A6E D; 2VK9 A; 1A36 A; 2NRO A; 1ZYM A; 2JA6 A; 4H3T A; 2K3N A; 1T3E A; 1Y1W A; 1A35 A; 1RR8 C; 4LMO A; 3KYL A; 2X0Q A; 1EJ9 A; 4PD1 A; 3FKI A; 3LR2 A; 1Y1V A; 1TWF A; 2MX9 A; 2NQU A; 2CW0 D; 2R4G A; 4NOK A; 5C9H A; 3U4Q A; 1V9M A; 4NOM A; 2LPI A; 2X0O A; 1T6P A; 2FIO A; 2A68 D; 5D8H B; 1YNJ D; 3LF9 A; 2F4Q A; 4F3E A; 2A6H D; 2FU3 A; 4IP9 A; 1Y69 8; 2X0P A; 1MIU A; 1EH1 A; 1K83 A; 1SEU A; 1NH3 A; 4V2Q A; 4FGU A; 4CQ5 A; 1K4S A; 1SFO A; 1TWG A; 4C5R A; 2LKM B; 2NQV A; 1ZYR D; 2JA5 A; 3DU5 A; 3K5L A; 1K4T A; 1G8L A; 2NQM A; 4TK3 A; 4L8I A; 2NRP A; 5ERQ A; 2WAQ A; 3GTM A; 1WQH A; 3CQZ A; 4PD0 A; 1I3Q A; 5JSB B; 3EZE A; 3H0G A; 4KB2 A; 1DD5 A; 1T8I A; 2MX8 A; 1WQG A; 4BAB A; 2E2I A; 4GFQ A; 3K57 A; 3LRD A; 4U91 A; 1R9T A; 2N1D B; 4FYD A; 1LPQ A; 5ERU A; 2A69 D; 4KC6 A; 4JLR C; 1HQM D; 4KDD A; 5ERV A; 2K3O A; 2WB1 A; 3K58 A; 2VUM A; 1R5Z A; 3K59 A; 2NRS A; 4Q5V A; 5ERR A; 2JA7 A; 2NQQ A; 2F5J A; 2MQA A; 4C5S A; 2R92 A; 2E2H A; 2FTS A; 1TWH A; 2LYI A; 1Y2M A; 4CEI A; 3P9A A; 3WVO A; 3GTP A; 4O26 A; 2EZC A; 3EZB A; 2X3L A; 4D3Y A; 3U44 A; 1I50 A; 4NOL A; 4C5U A; 1T6J A; 5D6G A; 1Q8I A; 3EZA A; 3M4A A; 2NVY A; 2PMZ A; 1RRJ A; 4CEH A; 3DU6 A; 2B63 A; 4AHC A; 5MLC 9; 4KAW X; 2EZA A; 3LR6 A; 4FXD A; 4V2R A; 3GTG A; 2AQL A; 4KB4 A; 5JSN B; 3MAQ A; 1WQF A; 2MP0 A; 3LR8 A; 2O5J D; 4C2M A; 1UZ5 A; 2R7Z A; 2NQN A; 1TGO A; 4TK1 A; 2LPJ A; 2Y0N A; 2NVX A; 4U90 A; 2BE5 D; 4AN8 A; 3HKZ A; #chains in the Genus database with same CATH homology 4QIW A; 4D3Z A; 2YU9 A; 3LHP S; 1IW7 D; 5G2R A; 1TWA A; 3GTO A; 5G2S A; 2Y0S A; 1ISE A; 4FBS A; 1FC5 A; 2NQS A; 4EJ3 A; 1IS1 A; 4TK4 A; 4OYD B; 3IAY A; 4AYB A; 4IP8 A; 1XI8 A; 3K5N A; 5CQG A; 1GE9 A; 2FIP A; 2LTH A; 3JSY A; 3K5O A; 4NWB A; 3GTL A; 1TWC A; 4QCL A; 4CEJ A; 1TL8 A; 1A31 A; 3K5M A; 2NQK A; 2R93 A; 3GTQ A; 5IZ2 A; 2B9S B; 3GTK A; 2NQR A; 1YNN D; 1G8R A; 2K3Q A; 5ERS A; 5ERT A; 1I6V D; 3SJR A; 3GTJ A; 1WCM A; 4Q5G A; 1EK8 A; 2N3E A; 1R49 A; 1SC7 A; 1SMY D; 2A6E D; 2VK9 A; 1A36 A; 2NRO A; 2JA6 A; 4H3T A; 2K3N A; 1T3E A; 1Y1W A; 1A35 A; 1RR8 C; 4LMO A; 3KYL A; 2X0Q A; 1EJ9 A; 4PD1 A; 3FKI A; 3LR2 A; 1Y1V A; 1TWF A; 2MX9 A; 2NQU A; 2CW0 D; 2R4G A; 4NOK A; 5C9H A; 3U4Q A; 1V9M A; 4NOM A; 2LPI A; 2X0O A; 2FIO A; 5D8H B; 2A68 D; 1YNJ D; 3LF9 A; 2F4Q A; 4F3E A; 2A6H D; 2FU3 A; 4IP9 A; 1Y69 8; 2X0P A; 1MIU A; 1EH1 A; 1K83 A; 1SEU A; 1NH3 A; 4FGU A; 1K4S A; 1SFO A; 1TWG A; 2LKM B; 2NQV A; 1ZYR D; 2JA5 A; 3DU5 A; 3K5L A; 1K4T A; 1G8L A; 2NQM A; 4TK3 A; 4L8I A; 2NRP A; 5ERQ A; 2WAQ A; 3GTM A; 1WQH A; 3CQZ A; 4PD0 A; 1I3Q A; 5JSB B; 3H0G A; 4KB2 A; 1DD5 A; 1T8I A; 2MX8 A; 1WQG A; 2E2I A; 4GFQ A; 3K57 A; 3LRD A; 4U91 A; 1R9T A; 2N1D B; 4FYD A; 1LPQ A; 5ERU A; 2A69 D; 4KC6 A; 4JLR C; 1HQM D; 4KDD A; 5ERV A; 2K3O A; 2WB1 A; 3K58 A; 2VUM A; 1R5Z A; 3K59 A; 2NRS A; 4Q5V A; 5ERR A; 2JA7 A; 2NQQ A; 2F5J A; 2MQA A; 2R92 A; 2E2H A; 2FTS A; 1TWH A; 2LYI A; 4CEI A; 3P9A A; 3WVO A; 3GTP A; 4O26 A; 2X3L A; 4D3Y A; 3U44 A; 1I50 A; 4NOL A; 5D6G A; 1Q8I A; 3M4A A; 2NVY A; 2PMZ A; 1RRJ A; 4CEH A; 3DU6 A; 2B63 A; 4AHC A; 5MLC 9; 4KAW X; 3LR6 A; 1WU2 A; 4FXD A; 3GTG A; 2AQL A; 4KB4 A; 5JSN B; 3MAQ A; 1WQF A; 3LR8 A; 2O5J D; 4C2M A; 1UZ5 A; 2R7Z A; 2NQN A; 1TGO A; 4TK1 A; 2LPJ A; 2Y0N A; 2NVX A; 4U90 A; 2BE5 D; 4AN8 A; 3HKZ A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
