1I6VD

Thermus aquaticus core rna polymerase-rifampicin complex
Total Genus 181
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
181
sequence length
1234
structure length
1174
Chain Sequence
KEVRKVRIALASPEKIRSWSYGEVEKPETEAKVCERCAVEVTRSIVRRYRMAHIELATPAAHIWFVKDVPSKIATLLDLSATELEQVLYFNKYIVLDPKAAVLDAVPVEKRQLLTDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIDARMGAEAIQELLKELDLEKLERELLEEMKHPSRARRAKARKRLEVVRAFLDSGNRPEWMILEAVPVLPPDATSDLNDLYRRLINRNNRLKKLLAQGAPEIIIRNEKRMLQEAVDAVIDNGRRGSPVTNPGSERPLRSLTDILSGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKRMALELFKPFLLKKMEEKAFAPNVKAARRMLERQRDIKDEVWDALEEVIHGKVVLLNRAPTLHRLGIQAFQPVLVEGQSIQLHPLVCEAFNADFDGDQMAVHVPLSSFAQAEARIQMLSAHNLLSPASGEPLAKPSRDIILGLYYITQVRKEKKGAGMAFATPEEALAAYERGEVALNAPIVVAGRETSVGRLKFVFANPDEALLAVAHGLLDLQDTVTTRYLGRRLETSPGRILFARIVGEAVGDEKVAQELIQMDVPQEKNSLKDLVYQAFLRLGMEKTARLLDALKYYGFTLSTTSGITIGIDDAVIPEEKQRYLEEADRKLRQIEQAYEMGFLTDRERYDQVIQLWTETTEKVTQAVFNNFEENYPFNPLYVMAQSGARGNPQQIRQLCGMRGLMQKPSGETFEVPVRSSFREGLTVLEYFISSHGARKGGADTALRTADSGYLTRKLVDVAHEIVVREADCGTTNYISVPLFQMDEVTRTLRLRKRSDIESGLYGRVLAREVEALGRRLEEGRYLSLEDVHFLIKAAEAGEVREVPVRSPLTCQTRYGVCQKCYGYDLSMARPVSIGEAVGVVAAESIGEPGTQLTMRTGTDITQGLPRVIELFEARRPKAKAVISEIDGVVRIEEGEDRLSVFVESEGFSKEYKLPKDARLLVKDGDYVEAGQPLTRGAIDPHQLLEAKGPEAVERYLVDEIQKVYRAQGVKLHDKHIEIVVRQMLKYVEVTDPGDSRLLEGQVLEKWDVEALNERLIAVPVAWKPLLMGVTKSALSTKSWLSAASFQNTTHVLTEAAIAGKKDELIGLKENVILGRLIPAGTGSDFVRFTQVVDQRTLKAIE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural mechanism for rifampicin inhibition of bacterial rna polymerase.
pubmed doi rcsb
molecule tags Transcription
molecule keywords DNA-DIRECTED RNA POLYMERASE
total genus 181
structure length 1174
sequence length 1234
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2001-03-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF00623 RNA_pol_Rpb1_2 RNA polymerase Rpb1, domain 2
D PF04983 RNA_pol_Rpb1_3 RNA polymerase Rpb1, domain 3
D PF04998 RNA_pol_Rpb1_5 RNA polymerase Rpb1, domain 5
D PF05000 RNA_pol_Rpb1_4 RNA polymerase Rpb1, domain 4
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.132.30 Mainly Alpha Orthogonal Bundle Topoisomerase I; Chain A, domain 4 Topoisomerase I; Chain A, domain 4 1i6vD03
1.10.274.100 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Enzyme I; Chain A, domain 2 1i6vD02
3.90.105.30 Alpha Beta Alpha-Beta Complex Molybdopterin biosynthesis moea protein, domain 2 Molybdopterin biosynthesis moea protein, domain 2 1i6vD05
1HQMD 2WAQA 2CW0D 1Y1WA 1TWFA 2A69D 2NVYA 3FKIA 3GTGA 2NVXA 2JA6A 3HKZA 2A68D 2R93A 2R92A 2R7ZA 3H0GA 4QIWA 4C2MA 2E2HA 3GTJA 2B63A 2BE5D 1IW7D 2A6ED 3GTLA 3GTQA 3GTPA 1TWAA 2YU9A 2E2IA 2JA7A 1SMYD 1Y1VA 2WB1A 3GTKA 1TWGA 2PMZA 1I3QA 3CQZA 1WCMA 1I50A 1I6VD 2O5JD 1TWCA 1YNJD 1YNND 3GTMA 1K83A 2JA5A 3GTOA 1ZYRD 2A6HD 1SFOA 4AYBA 1TWHA 1R9TA 2Y0SA 2VUMA
chains in the Genus database with same CATH superfamily
1A31A 2NQSA 4KC6A 3LRDA 1SEUA 4FXDA 3DU5A 4NWBA 2MP0A 4AHCA 3EZBA 2A68D 2R93A 2R92A 2R7ZA 1RRJA 2FIPA 4C5UA 4IP9A 4KB2A 5JSBB 1K4SA 3IAYA 2F4QA 1W27A 4V2RA 2AQLA 1T6PA 2K3QA 4F3EA 1EJ9A 1TWAA 3K5LA 2X0QA 2MX8A 1Y1VA 4V2QA 4H3TA 4CQ5A 1DD5A 1I3QA 3LR6A 1EK8A 3DU6A 2X0PA 2FU3A 1I50A 1WQGA 3SJRA 2YIIA 2MQAA 4TK1A 4TK3A 4Q5GA 2JA5A 2EZAA 5G2RA 5D6GA 3MAQA 2A6HD 3K5MA 3K58A 2FIOA 4PD1A 4CEJA 2Y0SA 5ERRA 4NOMA 3FKIA 2NQKA 4BAAA 4C5SA 2FTSA 4EJ3A 4KDDA 2JA6A 1NH3A 5C9HA 1ISEA 4Q5VA 1IW7D 1EH1A 2EZCA 3P9AA 1T3EA 4L8IA 2NQMA 1EZBA 2EZBA 2B9SB 1T8IA 3GTQA 2N1DB 4PD0A 5D8HB 2YU9A 3NZ4A 2NQVA 2NRPA 1A35A 4AN8A 5ERUA 4FGUA 1T6JA 3U44A 3CQZA 1WCMA 1UZ5A 1I6VD 3U4QA 2O5JD 2X0OA 2NQNA 1Y698 2NROA 3LHPS 1SFOA 2K3NA 1SC7A 2VUMA 1G8LA 2LPIA 4GFQA 4D3ZA 2LYIA 2NVXA 3EZAA 3JSYA 1Y2MA 1Q8IA 4QIWA 3LR8A 5MLC9 3M4AA 2B63A 2BE5D 1TGOA 3K5OA 2A6ED 1IS1A 2Y0NA 2NRSA 3GTLA 1WQHA 4O26A 4NOLA 3GTPA 2N3EA 2E2IA 2JA7A 1SMYD 2WB1A 4OYDB 1R49A 4D3YA 2F5JA 2VK9A 4C5RA 1TWGA 2PMZA 5ERVA 4CEHA 1MIUA 1LPQA 1TWCA 1EZAA 3GTMA 1FC5A 3GTOA 4FBSA 3K59A 1ZYMA 1TWHA 1R9TA 4TK4A 1R5ZA 1HQMD 2WAQA 2CW0D 3WVOA 1TWFA 2A69D 2NVYA 3KYLA 1TL8A 1Y1WA 2NQUA 3GTGA 1WQFA 3K5NA 3HKZA 2NQRA 5JSNB 3H0GA 3K57A 4C2MA 2X3LA 2K3OA 2LKMB 2E2HA 3GTJA 4U90A 1XI8A 1A36A 2HWGA 2LTHA 1V9MA 4LMOA 1GE9A 3EZEA 2HROA 4KB4A 5ERSA 5ERTA 1WU2A 3LR2A 4BABA 4U91A 3GTKA 5IZ2A 4JLRC 5CQGA 1K4TA 4IP8A 2MX9A 4NOKA 3LF9A 1G8RA 1YNJD 1YNND 4QCLA 2LPJA 2R4GA 2NQQA 1K83A 4CEIA 5ERQA 5G2SA 1ZYRD 1RR8C 4FYDA 4AYBA 4C6GA 4KAWX
chains in the Genus database with same CATH topology
1A31A 2NQSA 4KC6A 3LRDA 1SEUA 4FXDA 3DU5A 4NWBA 4AHCA 2A68D 2R93A 2R92A 2R7ZA 1RRJA 2FIPA 4IP9A 4KB2A 5JSBB 1K4SA 3IAYA 2F4QA 2AQLA 2K3QA 4F3EA 1EJ9A 1TWAA 3K5LA 2X0QA 2MX8A 1Y1VA 4H3TA 1DD5A 1I3QA 3LR6A 1EK8A 3DU6A 2X0PA 2FU3A 1I50A 1WQGA 3SJRA 2MQAA 4TK1A 4TK3A 4Q5GA 2JA5A 5G2RA 5D6GA 3MAQA 2A6HD 3K5MA 3K58A 2FIOA 4PD1A 4CEJA 2Y0SA 5ERRA 4NOMA 3FKIA 2NQKA 2FTSA 4EJ3A 4KDDA 2JA6A 1NH3A 5C9HA 1ISEA 4Q5VA 1IW7D 1EH1A 3P9AA 1T3EA 4L8IA 2NQMA 2B9SB 1T8IA 3GTQA 2N1DB 4PD0A 5D8HB 2YU9A 2NQVA 2NRPA 1A35A 4AN8A 5ERUA 4FGUA 3U44A 3CQZA 1WCMA 1UZ5A 1I6VD 3U4QA 2O5JD 2X0OA 2NQNA 1Y698 2NROA 3LHPS 1SFOA 2K3NA 1SC7A 2VUMA 1G8LA 2LPIA 4GFQA 4D3ZA 2LYIA 2NVXA 3JSYA 1Q8IA 4QIWA 3LR8A 5MLC9 3M4AA 2B63A 2BE5D 1TGOA 3K5OA 2A6ED 1IS1A 2Y0NA 2NRSA 3GTLA 1WQHA 4O26A 4NOLA 3GTPA 2N3EA 2E2IA 2JA7A 1SMYD 2WB1A 4OYDB 1R49A 4D3YA 2F5JA 2VK9A 1TWGA 2PMZA 5ERVA 4CEHA 1MIUA 1LPQA 1TWCA 3GTMA 1FC5A 3GTOA 4FBSA 3K59A 1TWHA 1R9TA 4TK4A 1R5ZA 1HQMD 2WAQA 2CW0D 3WVOA 1TWFA 2A69D 2NVYA 3KYLA 1TL8A 1Y1WA 2NQUA 3GTGA 1WQFA 3K5NA 3HKZA 2NQRA 5JSNB 3H0GA 3K57A 4C2MA 2X3LA 2K3OA 2LKMB 2E2HA 3GTJA 4U90A 1XI8A 1A36A 2LTHA 1V9MA 4LMOA 1GE9A 5ERSA 4KB4A 5ERTA 1WU2A 3LR2A 4U91A 3GTKA 5IZ2A 4JLRC 5CQGA 1K4TA 4IP8A 2MX9A 4NOKA 3LF9A 1G8RA 1YNJD 1YNND 4QCLA 2LPJA 2R4GA 2NQQA 1K83A 4CEIA 5ERQA 5G2SA 1ZYRD 1RR8C 4FYDA 4AYBA 4KAWX
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HQM D;  2WAQ A;  2CW0 D;  1Y1W A;  1TWF A;  2A69 D;  2NVY A;  3FKI A;  3GTG A;  2NVX A;  2JA6 A;  3HKZ A;  2A68 D;  2R93 A;  2R92 A;  2R7Z A;  3H0G A;  4QIW A;  4C2M A;  2E2H A;  3GTJ A;  2B63 A;  2BE5 D;  1IW7 D;  2A6E D;  3GTL A;  3GTQ A;  3GTP A;  1TWA A;  2YU9 A;  2E2I A;  2JA7 A;  1SMY D;  1Y1V A;  2WB1 A;  3GTK A;  1TWG A;  2PMZ A;  1I3Q A;  3CQZ A;  1WCM A;  1I50 A;  1I6V D;  2O5J D;  1TWC A;  1YNJ D;  1YNN D;  3GTM A;  1K83 A;  2JA5 A;  3GTO A;  1ZYR D;  2A6H D;  1SFO A;  4AYB A;  1TWH A;  1R9T A;  2Y0S A;  2VUM A; 
#chains in the Genus database with same CATH topology
 1A31 A;  2NQS A;  4KC6 A;  3LRD A;  1SEU A;  4FXD A;  3DU5 A;  4NWB A;  2MP0 A;  4AHC A;  3EZB A;  2A68 D;  2R93 A;  2R92 A;  2R7Z A;  1RRJ A;  2FIP A;  4C5U A;  4IP9 A;  4KB2 A;  5JSB B;  1K4S A;  3IAY A;  2F4Q A;  1W27 A;  4V2R A;  2AQL A;  1T6P A;  2K3Q A;  4F3E A;  1EJ9 A;  1TWA A;  3K5L A;  2X0Q A;  2MX8 A;  1Y1V A;  4V2Q A;  4H3T A;  4CQ5 A;  1DD5 A;  1I3Q A;  3LR6 A;  1EK8 A;  3DU6 A;  2X0P A;  2FU3 A;  1I50 A;  1WQG A;  3SJR A;  2YII A;  2MQA A;  4TK1 A;  4TK3 A;  4Q5G A;  2JA5 A;  2EZA A;  5G2R A;  5D6G A;  3MAQ A;  2A6H D;  3K5M A;  3K58 A;  2FIO A;  4PD1 A;  4CEJ A;  2Y0S A;  5ERR A;  4NOM A;  3FKI A;  2NQK A;  4BAA A;  4C5S A;  2FTS A;  4EJ3 A;  4KDD A;  2JA6 A;  1NH3 A;  5C9H A;  1ISE A;  4Q5V A;  1IW7 D;  1EH1 A;  2EZC A;  3P9A A;  1T3E A;  4L8I A;  2NQM A;  1EZB A;  2EZB A;  2B9S B;  1T8I A;  3GTQ A;  2N1D B;  4PD0 A;  5D8H B;  2YU9 A;  3NZ4 A;  2NQV A;  2NRP A;  1A35 A;  4AN8 A;  5ERU A;  4FGU A;  1T6J A;  3U44 A;  3CQZ A;  1WCM A;  1UZ5 A;  1I6V D;  3U4Q A;  2O5J D;  2X0O A;  2NQN A;  1Y69 8;  2NRO A;  3LHP S;  1SFO A;  2K3N A;  1SC7 A;  2VUM A;  1G8L A;  2LPI A;  4GFQ A;  4D3Z A;  2LYI A;  2NVX A;  3EZA A;  3JSY A;  1Y2M A;  1Q8I A;  4QIW A;  3LR8 A;  5MLC 9;  3M4A A;  2B63 A;  2BE5 D;  1TGO A;  3K5O A;  2A6E D;  1IS1 A;  2Y0N A;  2NRS A;  3GTL A;  1WQH A;  4O26 A;  4NOL A;  3GTP A;  2N3E A;  2E2I A;  2JA7 A;  1SMY D;  2WB1 A;  4OYD B;  1R49 A;  4D3Y A;  2F5J A;  2VK9 A;  4C5R A;  1TWG A;  2PMZ A;  5ERV A;  4CEH A;  1MIU A;  1LPQ A;  1TWC A;  1EZA A;  3GTM A;  1FC5 A;  3GTO A;  4FBS A;  3K59 A;  1ZYM A;  1TWH A;  1R9T A;  4TK4 A;  1R5Z A;  1HQM D;  2WAQ A;  2CW0 D;  3WVO A;  1TWF A;  2A69 D;  2NVY A;  3KYL A;  1TL8 A;  1Y1W A;  2NQU A;  3GTG A;  1WQF A;  3K5N A;  3HKZ A;  2NQR A;  5JSN B;  3H0G A;  3K57 A;  4C2M A;  2X3L A;  2K3O A;  2LKM B;  2E2H A;  3GTJ A;  4U90 A;  1XI8 A;  1A36 A;  2HWG A;  2LTH A;  1V9M A;  4LMO A;  1GE9 A;  3EZE A;  2HRO A;  4KB4 A;  5ERS A;  5ERT A;  1WU2 A;  3LR2 A;  4BAB A;  4U91 A;  3GTK A;  5IZ2 A;  4JLR C;  5CQG A;  1K4T A;  4IP8 A;  2MX9 A;  4NOK A;  3LF9 A;  1G8R A;  1YNJ D;  1YNN D;  4QCL A;  2LPJ A;  2R4G A;  2NQQ A;  1K83 A;  4CEI A;  5ERQ A;  5G2S A;  1ZYR D;  1RR8 C;  4FYD A;  4AYB A;  4C6G A;  4KAW X; 
#chains in the Genus database with same CATH homology
 1A31 A;  2NQS A;  4KC6 A;  3LRD A;  1SEU A;  4FXD A;  3DU5 A;  4NWB A;  4AHC A;  2A68 D;  2R93 A;  2R92 A;  2R7Z A;  1RRJ A;  2FIP A;  4IP9 A;  4KB2 A;  5JSB B;  1K4S A;  3IAY A;  2F4Q A;  2AQL A;  2K3Q A;  4F3E A;  1EJ9 A;  1TWA A;  3K5L A;  2X0Q A;  2MX8 A;  1Y1V A;  4H3T A;  1DD5 A;  1I3Q A;  3LR6 A;  1EK8 A;  3DU6 A;  2X0P A;  2FU3 A;  1I50 A;  1WQG A;  3SJR A;  2MQA A;  4TK1 A;  4TK3 A;  4Q5G A;  2JA5 A;  5G2R A;  5D6G A;  3MAQ A;  2A6H D;  3K5M A;  3K58 A;  2FIO A;  4PD1 A;  4CEJ A;  2Y0S A;  5ERR A;  4NOM A;  3FKI A;  2NQK A;  2FTS A;  4EJ3 A;  4KDD A;  2JA6 A;  1NH3 A;  5C9H A;  1ISE A;  4Q5V A;  1IW7 D;  1EH1 A;  3P9A A;  1T3E A;  4L8I A;  2NQM A;  2B9S B;  1T8I A;  3GTQ A;  2N1D B;  4PD0 A;  5D8H B;  2YU9 A;  2NQV A;  2NRP A;  1A35 A;  4AN8 A;  5ERU A;  4FGU A;  3U44 A;  3CQZ A;  1WCM A;  1UZ5 A;  1I6V D;  3U4Q A;  2O5J D;  2X0O A;  2NQN A;  1Y69 8;  2NRO A;  3LHP S;  1SFO A;  2K3N A;  1SC7 A;  2VUM A;  1G8L A;  2LPI A;  4GFQ A;  4D3Z A;  2LYI A;  2NVX A;  3JSY A;  1Q8I A;  4QIW A;  3LR8 A;  5MLC 9;  3M4A A;  2B63 A;  2BE5 D;  1TGO A;  3K5O A;  2A6E D;  1IS1 A;  2Y0N A;  2NRS A;  3GTL A;  1WQH A;  4O26 A;  4NOL A;  3GTP A;  2N3E A;  2E2I A;  2JA7 A;  1SMY D;  2WB1 A;  4OYD B;  1R49 A;  4D3Y A;  2F5J A;  2VK9 A;  1TWG A;  2PMZ A;  5ERV A;  4CEH A;  1MIU A;  1LPQ A;  1TWC A;  3GTM A;  1FC5 A;  3GTO A;  4FBS A;  3K59 A;  1TWH A;  1R9T A;  4TK4 A;  1R5Z A;  1HQM D;  2WAQ A;  2CW0 D;  3WVO A;  1TWF A;  2A69 D;  2NVY A;  3KYL A;  1TL8 A;  1Y1W A;  2NQU A;  3GTG A;  1WQF A;  3K5N A;  3HKZ A;  2NQR A;  5JSN B;  3H0G A;  3K57 A;  4C2M A;  2X3L A;  2K3O A;  2LKM B;  2E2H A;  3GTJ A;  4U90 A;  1XI8 A;  1A36 A;  2LTH A;  1V9M A;  4LMO A;  1GE9 A;  5ERS A;  4KB4 A;  5ERT A;  1WU2 A;  3LR2 A;  4U91 A;  3GTK A;  5IZ2 A;  4JLR C;  5CQG A;  1K4T A;  4IP8 A;  2MX9 A;  4NOK A;  3LF9 A;  1G8R A;  1YNJ D;  1YNN D;  4QCL A;  2LPJ A;  2R4G A;  2NQQ A;  1K83 A;  4CEI A;  5ERQ A;  5G2S A;  1ZYR D;  1RR8 C;  4FYD A;  4AYB A;  4KAW X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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