4C5UA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 255
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
255
sequence length
669
structure length
641
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTKVDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSASGDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRAALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHKDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMMONIA-LYASE
publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 255
structure length 641
sequence length 669
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c5uA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c5uA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c5uA02
1Q5NA 4NLEA 1U15A 1FUPA 5F92A 2O7BA 3BHGA 3KDYA 1T6JA 2O78A 3NO9A 4HGVA 2PFMA 4C5UA 3RD8A 1C3CA 1TJVA 3R6YA 1HY1A 4V2QA 2O7DA 2HVGA 1GKJA 1XWOA 5EYTA 1I0AA 4BAAA 1YFEA 2RJRA 1J3UA 4C6GA 1FURA 5F91A 1Y2MA 2OHYA 4FLCA 3GTDA 5D6BA 4MX2A 1RE5A 1KQ7A 3GZHA 3C8TA 3CZOA 3UNVA 1HY0A 2PTQA 4C5SA 4EFCA 2QVEA 1K62A 3QBPA 4APBA 1TJ7A 2NYFA 5HW2A 3OCEA 1TJWA 1GKMA 4APAA 1T6PA 2O6YA 1GK2A 1K7WA 4CQ5A 1DCNA 2PTSA 2X75A 3R6VA 2NYNA 2FUSA 1B8FA 2E9FA 3TV2A 1W27A 1VDKA 2VD6A 2YIIA 1DOFA 5EYVA 3NZ4A 1TJUA 1U16A 4ADLA 1C3UA 1JSWA 2J91A 3E04A 4FFXA 3RRPA 4V2RA 4C5RA 1GK3A 4EEIA 1YISA 1FUOA 2RJSA 1EB4A 4NSLA 1FUQA 4ADMA 1AUWA 3R6QA 2QGAB 3KDZA 2PTRA 3OCFA 2O7FA 1YFMA 4BABA 2O7EA
chains in the Genus database with same CATH superfamily
2YU9A 1I3QA 3CRVA 3LR2A 1Q5NA 3GTQA 1SFOA 4NLEA 1R9TA 4C2MA 4CEHA 1U15A 1FUPA 2A69D 2K3OA 5F92A 2A6ED 2O7BA 3BHGA 5M0JA 2MQAA 1ZYMA 1TWHA 3GTJA 1K83A 5IZ2A 3KDYA 1T6JA 2O78A 3NO9A 1I6VD 2LPJA 4HGVA 2PFMA 2HWGA 4C5UA 3RD8A 2LYIA 2Y0NA 1C3CA 1HQMD 1YNJD 1TJVA 3R6YA 1HY1A 4A15A 4V2QA 5H8WA 2O7DA 2HVGA 2NVYA 2JA7A 1GKJA 1Y1WA 2FENA 2K3NA 2FIPA 1XWOA 1I0AA 4BAAA 3GTLA 1YFEA 2RJRA 5EYTA 1J3UA 2R93A 1TWFA 4C6GA 3GTMA 1FURA 5F91A 1Y2MA 2R92A 3U4QA 2OHYA 2N1DB 1EZAA 4FLCA 3GTDA 5D6BA 3CRW1 4MX2A 2AQLA 1RE5A 1KQ7A 3LR8A 3EZAA 2BE5D 3GZHA 2E2HA 3C8TA 3CZOA 2MX8A 3GTGA 3UNVA 1HY0A 3H0GA 2PTQA 2EZAA 4C5SA 2F5JA 4EFCA 2LTHA 2NVXA 2QVEA 1XLYA 1YFMA 1K62A 3QBPA 2X0QA 4APBA 1TJ7A 2NYFA 2A68D 5HW2A 4CEJA 3OCEA 1TJWA 1GKMA 1I50A 1XMCA 4APAA 1T6PA 2O6YA 2MP0A 1TWCA 1GK2A 1K7WA 4CQ5A 1DCNA 2VK9A 2PTSA 2E2IA 2X0OA 2X75A 3R6VA 2NYNA 4WNLA 2LPIA 2FUSA 1B8FA 2A6HD 2E9FA 3LRDA 3TV2A 1TWAA 2JA6A 1EZBA 1W27A 2O5JD 1VDKA 2VD6A 2YIIA 1DOFA 5EYVA 1SMYD 1YNND 5M0IA 3NZ4A 4QIWA 2LKMB 2EZCA 1TJUA 1U16A 2FIOA 1TWGA 4ADLA 1C3UA 2B63A 2R7ZA 2VL7A 1JSWA 3CQZA 2J91A 3E04A 4FFXA 1Y1VA 3RRPA 4V2RA 4C5RA 3GTKA 1GK3A 4EEIA 1ZYRD 2CW0D 2O7EA 1YISA 3U44A 1FUOA 4FBSA 2RJSA 1EB4A 2K3QA 4NSLA 2FELA 1FUQA 4ADMA 1WCMA 1AUWA 3R6QA 2VUMA 2VSFA 2N3EA 2HROA 3GTOA 3FKIA 1XL8A 2MX9A 3GTPA 2QGAB 1XL7A 1XMDA 3LR6A 3EZBA 2PTRA 4CEIA 3KDZA 3OCFA 2EZBA 2O7FA 2JA5A 3EZEA 4BABA 2X0PA 1IW7D
chains in the Genus database with same CATH topology
1Q5NA 4NLEA 1U15A 1FUPA 5F92A 2O7BA 3BHGA 3KDYA 1T6JA 2O78A 3NO9A 4HGVA 2PFMA 4C5UA 3RD8A 1C3CA 1TJVA 3R6YA 1HY1A 4V2QA 2O7DA 2HVGA 1GKJA 1XWOA 5EYTA 1I0AA 4BAAA 1YFEA 2RJRA 1J3UA 4C6GA 1FURA 5F91A 1Y2MA 2OHYA 4FLCA 3GTDA 5D6BA 4MX2A 1RE5A 1KQ7A 3GZHA 3C8TA 3CZOA 3UNVA 1HY0A 2PTQA 4C5SA 4EFCA 2QVEA 1K62A 3QBPA 4APBA 1TJ7A 2NYFA 5HW2A 3OCEA 1TJWA 1GKMA 4APAA 1T6PA 2O6YA 1GK2A 1K7WA 4CQ5A 1DCNA 2PTSA 2X75A 3R6VA 2NYNA 2FUSA 1B8FA 2E9FA 3TV2A 1W27A 1VDKA 2VD6A 2YIIA 1DOFA 5EYVA 3NZ4A 1TJUA 1U16A 4ADLA 1C3UA 1JSWA 2J91A 3E04A 4FFXA 3RRPA 4V2RA 4C5RA 1GK3A 4EEIA 1YISA 1FUOA 2RJSA 1EB4A 4NSLA 1FUQA 4ADMA 1AUWA 3R6QA 2QGAB 3KDZA 2PTRA 3OCFA 2O7FA 1YFMA 4BABA 2O7EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Q5N A;  4NLE A;  1U15 A;  1FUP A;  5F92 A;  2O7B A;  3BHG A;  3KDY A;  1T6J A;  2O78 A;  3NO9 A;  4HGV A;  2PFM A;  4C5U A;  3RD8 A;  1C3C A;  1TJV A;  3R6Y A;  1HY1 A;  4V2Q A;  2O7D A;  2HVG A;  1GKJ A;  1XWO A;  5EYT A;  1I0A A;  4BAA A;  1YFE A;  2RJR A;  1J3U A;  4C6G A;  1FUR A;  5F91 A;  1Y2M A;  2OHY A;  4FLC A;  3GTD A;  5D6B A;  4MX2 A;  1RE5 A;  1KQ7 A;  3GZH A;  3C8T A;  3CZO A;  3UNV A;  1HY0 A;  2PTQ A;  4C5S A;  4EFC A;  2QVE A;  1K62 A;  3QBP A;  4APB A;  1TJ7 A;  2NYF A;  5HW2 A;  3OCE A;  1TJW A;  1GKM A;  4APA A;  1T6P A;  2O6Y A;  1GK2 A;  1K7W A;  4CQ5 A;  1DCN A;  2PTS A;  2X75 A;  3R6V A;  2NYN A;  2FUS A;  1B8F A;  2E9F A;  3TV2 A;  1W27 A;  1VDK A;  2VD6 A;  2YII A;  1DOF A;  5EYV A;  3NZ4 A;  1TJU A;  1U16 A;  4ADL A;  1C3U A;  1JSW A;  2J91 A;  3E04 A;  4FFX A;  3RRP A;  4V2R A;  4C5R A;  1GK3 A;  4EEI A;  1YIS A;  1FUO A;  2RJS A;  1EB4 A;  4NSL A;  1FUQ A;  4ADM A;  1AUW A;  3R6Q A;  2QGA B;  3KDZ A;  2PTR A;  3OCF A;  2O7F A;  1YFM A;  4BAB A;  2O7E A; 
#chains in the Genus database with same CATH topology
 2YU9 A;  1I3Q A;  3CRV A;  3LR2 A;  1Q5N A;  3GTQ A;  1SFO A;  4NLE A;  1R9T A;  4C2M A;  4CEH A;  1U15 A;  1FUP A;  2A69 D;  2K3O A;  5F92 A;  2A6E D;  2O7B A;  3BHG A;  5M0J A;  2MQA A;  1ZYM A;  1TWH A;  3GTJ A;  1K83 A;  5IZ2 A;  3KDY A;  1T6J A;  2O78 A;  3NO9 A;  1I6V D;  2LPJ A;  4HGV A;  2PFM A;  2HWG A;  4C5U A;  3RD8 A;  2LYI A;  2Y0N A;  1C3C A;  1HQM D;  1YNJ D;  1TJV A;  3R6Y A;  1HY1 A;  4A15 A;  4V2Q A;  5H8W A;  2O7D A;  2HVG A;  2NVY A;  2JA7 A;  1GKJ A;  1Y1W A;  2FEN A;  2K3N A;  2FIP A;  1XWO A;  1I0A A;  4BAA A;  3GTL A;  1YFE A;  2RJR A;  5EYT A;  1J3U A;  2R93 A;  1TWF A;  4C6G A;  3GTM A;  1FUR A;  5F91 A;  1Y2M A;  2R92 A;  3U4Q A;  2OHY A;  2N1D B;  1EZA A;  4FLC A;  3GTD A;  5D6B A;  3CRW 1;  4MX2 A;  2AQL A;  1RE5 A;  1KQ7 A;  3LR8 A;  3EZA A;  2BE5 D;  3GZH A;  2E2H A;  3C8T A;  3CZO A;  2MX8 A;  3GTG A;  3UNV A;  1HY0 A;  3H0G A;  2PTQ A;  2EZA A;  4C5S A;  2F5J A;  4EFC A;  2LTH A;  2NVX A;  2QVE A;  1XLY A;  1YFM A;  1K62 A;  3QBP A;  2X0Q A;  4APB A;  1TJ7 A;  2NYF A;  2A68 D;  5HW2 A;  4CEJ A;  3OCE A;  1TJW A;  1GKM A;  1I50 A;  1XMC A;  4APA A;  1T6P A;  2O6Y A;  2MP0 A;  1TWC A;  1GK2 A;  1K7W A;  4CQ5 A;  1DCN A;  2VK9 A;  2PTS A;  2E2I A;  2X0O A;  2X75 A;  3R6V A;  2NYN A;  4WNL A;  2LPI A;  2FUS A;  1B8F A;  2A6H D;  2E9F A;  3LRD A;  3TV2 A;  1TWA A;  2JA6 A;  1EZB A;  1W27 A;  2O5J D;  1VDK A;  2VD6 A;  2YII A;  1DOF A;  5EYV A;  1SMY D;  1YNN D;  5M0I A;  3NZ4 A;  4QIW A;  2LKM B;  2EZC A;  1TJU A;  1U16 A;  2FIO A;  1TWG A;  4ADL A;  1C3U A;  2B63 A;  2R7Z A;  2VL7 A;  1JSW A;  3CQZ A;  2J91 A;  3E04 A;  4FFX A;  1Y1V A;  3RRP A;  4V2R A;  4C5R A;  3GTK A;  1GK3 A;  4EEI A;  1ZYR D;  2CW0 D;  2O7E A;  1YIS A;  3U44 A;  1FUO A;  4FBS A;  2RJS A;  1EB4 A;  2K3Q A;  4NSL A;  2FEL A;  1FUQ A;  4ADM A;  1WCM A;  1AUW A;  3R6Q A;  2VUM A;  2VSF A;  2N3E A;  2HRO A;  3GTO A;  3FKI A;  1XL8 A;  2MX9 A;  3GTP A;  2QGA B;  1XL7 A;  1XMD A;  3LR6 A;  3EZB A;  2PTR A;  4CEI A;  3KDZ A;  3OCF A;  2EZB A;  2O7F A;  2JA5 A;  3EZE A;  4BAB A;  2X0P A;  1IW7 D; 
#chains in the Genus database with same CATH homology
 1Q5N A;  4NLE A;  1U15 A;  1FUP A;  5F92 A;  2O7B A;  3BHG A;  3KDY A;  1T6J A;  2O78 A;  3NO9 A;  4HGV A;  2PFM A;  4C5U A;  3RD8 A;  1C3C A;  1TJV A;  3R6Y A;  1HY1 A;  4V2Q A;  2O7D A;  2HVG A;  1GKJ A;  1XWO A;  5EYT A;  1I0A A;  4BAA A;  1YFE A;  2RJR A;  1J3U A;  4C6G A;  1FUR A;  5F91 A;  1Y2M A;  2OHY A;  4FLC A;  3GTD A;  5D6B A;  4MX2 A;  1RE5 A;  1KQ7 A;  3GZH A;  3C8T A;  3CZO A;  3UNV A;  1HY0 A;  2PTQ A;  4C5S A;  4EFC A;  2QVE A;  1K62 A;  3QBP A;  4APB A;  1TJ7 A;  2NYF A;  5HW2 A;  3OCE A;  1TJW A;  1GKM A;  4APA A;  1T6P A;  2O6Y A;  1GK2 A;  1K7W A;  4CQ5 A;  1DCN A;  2PTS A;  2X75 A;  3R6V A;  2NYN A;  2FUS A;  1B8F A;  2E9F A;  3TV2 A;  1W27 A;  1VDK A;  2VD6 A;  2YII A;  1DOF A;  5EYV A;  3NZ4 A;  1TJU A;  1U16 A;  4ADL A;  1C3U A;  1JSW A;  2J91 A;  3E04 A;  4FFX A;  3RRP A;  4V2R A;  4C5R A;  1GK3 A;  4EEI A;  1YIS A;  1FUO A;  2RJS A;  1EB4 A;  4NSL A;  1FUQ A;  4ADM A;  1AUW A;  3R6Q A;  2QGA B;  3KDZ A;  2PTR A;  3OCF A;  2O7F A;  1YFM A;  4BAB A;  2O7E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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