4C5UA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 255
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
255
sequence length
669
structure length
641
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTKVDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSASGDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRAALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHKDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE
total genus 255
structure length 641
sequence length 669
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c5uA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c5uA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c5uA02
1XWOA 2PFMA 2O7EA 1TJ7A 4V2QA 2PTQA 4ADLA 1B8FA 3GZHA 5HW2A 4HGVA 1AUWA 3R6VA 2O7FA 1YFMA 1YISA 4FFXA 1T6JA 1GK3A 4MX2A 1GK2A 1C3UA 3R6QA 1HY0A 2QGAB 1W27A 3NO9A 3C8TA 3UNVA 1EB4A 1I0AA 1TJWA 1DCNA 4APAA 3BHGA 5EYVA 1FUOA 1FUPA 4APBA 3KDYA 1KQ7A 2NYNA 2X75A 5F92A 4BABA 4CQ5A 2O7DA 1U15A 3R6YA 1Q5NA 1T6PA 2PTRA 2QVEA 4NLEA 1Y2MA 1GKMA 5EYTA 1FUQA 4FLCA 1JSWA 4V2RA 1U16A 2PTSA 1VDKA 3E04A 2HVGA 4NSLA 3RD8A 1K7WA 1C3CA 3OCFA 4C6GA 4C5RA 3QBPA 2RJSA 4C5UA 5F91A 2O6YA 2E9FA 2YIIA 1HY1A 3GTDA 2NYFA 1J3UA 4C5SA 1TJVA 2O78A 1YFEA 1K62A 4EEIA 1TJUA 4EFCA 1RE5A 3NZ4A 2J91A 2FUSA 3OCEA 4ADMA 3RRPA 5D6BA 3CZOA 1DOFA 2RJRA 3TV2A 1FURA 2VD6A 2OHYA 2O7BA 4BAAA 3KDZA 1GKJA
chains in the Genus database with same CATH superfamily
1XWOA 1GKJA 2PFMA 2VK9A 2O7EA 1YNND 2FELA 2LKMB 4V2QA 5IZ2A 1TJ7A 3LR8A 2A68D 2PTQA 4ADLA 1B8FA 2MX8A 1EZAA 3GZHA 4HGVA 5HW2A 2CW0D 3GTGA 1AUWA 3R6VA 2EZAA 2O7FA 3GTMA 1TWAA 2FIOA 3LR2A 1WCMA 1YFMA 1YISA 4FFXA 1EZBA 1T6JA 1GK3A 4MX2A 1I6VD 3LRDA 1GK2A 4C2MA 1YNJD 2N3EA 1TWCA 1I3QA 1C3UA 1HY0A 2QGAB 1W27A 3NO9A 3R6QA 4A15A 4CEHA 3U44A 3C8TA 1TWFA 3UNVA 1EB4A 5M0JA 1I0AA 2HWGA 1TJWA 2K3NA 4QIWA 1DCNA 2JA6A 3BHGA 5EYVA 2LPIA 1FUOA 1FUPA 3EZAA 1XL7A 4APAA 3KDYA 1KQ7A 2NYNA 4APBA 2X75A 5F92A 2LTHA 1ZYRD 4BABA 1I50A 3H0GA 4CQ5A 2YU9A 2O7DA 2O5JD 2JA5A 1U15A 5F91A 3R6YA 5M0IA 2VSFA 2MP0A 3LR6A 1Q5NA 2B63A 1T6PA 2PTRA 1XLYA 2E2IA 1ZYMA 2QVEA 1Y1WA 4NLEA 1Y2MA 2AQLA 1GKMA 5EYTA 1FUQA 2N1DB 4FLCA 2X0QA 2FENA 1IW7D 2EZCA 4WNLA 1JSWA 1SMYD 2R93A 4V2RA 1U16A 2LPJA 4CEIA 2PTSA 1VDKA 3E04A 3FKIA 2K3OA 3GTJA 2HVGA 3GTPA 1Y1VA 4NSLA 3RD8A 1K7WA 1C3CA 1XL8A 1TWGA 2A6HD 3OCFA 2BE5D 4C6GA 3GTLA 4C5RA 3GTQA 3QBPA 3U4QA 2RJSA 4C5UA 5H8WA 2EZBA 1SFOA 2R92A 2NVXA 2YIIA 1HY1A 2E9FA 2O6YA 3GTKA 3GTDA 3KDZA 2A69D 2F5JA 2LYIA 2NYFA 1J3UA 2NVYA 1K83A 3GTOA 4C5SA 1TJVA 2VUMA 2O78A 2X0PA 2JA7A 1YFEA 3CQZA 1K62A 3EZEA 1R9TA 4CEJA 4EEIA 3CRW1 2MQAA 1TJUA 2Y0NA 4EFCA 1RE5A 2MX9A 3NZ4A 2J91A 1TWHA 2FUSA 2X0OA 2R7ZA 2FIPA 3OCEA 2HROA 4ADMA 1XMDA 3CRVA 3RRPA 5D6BA 3CZOA 1DOFA 3EZBA 2RJRA 3TV2A 2K3QA 1HQMD 1FURA 2VD6A 2OHYA 2O7BA 4BAAA 1XMCA 2E2HA 2VL7A 4FBSA 2A6ED
chains in the Genus database with same CATH topology
1XWOA 2PFMA 2O7EA 1TJ7A 4V2QA 2PTQA 4ADLA 1B8FA 3GZHA 5HW2A 4HGVA 1AUWA 3R6VA 2O7FA 1YFMA 1YISA 4FFXA 1T6JA 1GK3A 4MX2A 1GK2A 1C3UA 3R6QA 1HY0A 2QGAB 1W27A 3NO9A 3C8TA 3UNVA 1EB4A 1I0AA 1TJWA 1DCNA 4APAA 3BHGA 5EYVA 1FUOA 1FUPA 4APBA 3KDYA 1KQ7A 2NYNA 2X75A 5F92A 4BABA 4CQ5A 2O7DA 1U15A 3R6YA 1Q5NA 1T6PA 2PTRA 2QVEA 4NLEA 1Y2MA 1GKMA 5EYTA 1FUQA 4FLCA 1JSWA 4V2RA 1U16A 2PTSA 1VDKA 3E04A 2HVGA 4NSLA 3RD8A 1K7WA 1C3CA 3OCFA 4C6GA 4C5RA 3QBPA 2RJSA 4C5UA 5F91A 2O6YA 2E9FA 2YIIA 1HY1A 3GTDA 2NYFA 1J3UA 4C5SA 1TJVA 2O78A 1YFEA 1K62A 4EEIA 1TJUA 4EFCA 1RE5A 3NZ4A 2J91A 2FUSA 3OCEA 4ADMA 3RRPA 5D6BA 3CZOA 1DOFA 2RJRA 3TV2A 1FURA 2VD6A 2OHYA 2O7BA 4BAAA 3KDZA 1GKJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XWO A;  2PFM A;  2O7E A;  1TJ7 A;  4V2Q A;  2PTQ A;  4ADL A;  1B8F A;  3GZH A;  5HW2 A;  4HGV A;  1AUW A;  3R6V A;  2O7F A;  1YFM A;  1YIS A;  4FFX A;  1T6J A;  1GK3 A;  4MX2 A;  1GK2 A;  1C3U A;  3R6Q A;  1HY0 A;  2QGA B;  1W27 A;  3NO9 A;  3C8T A;  3UNV A;  1EB4 A;  1I0A A;  1TJW A;  1DCN A;  4APA A;  3BHG A;  5EYV A;  1FUO A;  1FUP A;  4APB A;  3KDY A;  1KQ7 A;  2NYN A;  2X75 A;  5F92 A;  4BAB A;  4CQ5 A;  2O7D A;  1U15 A;  3R6Y A;  1Q5N A;  1T6P A;  2PTR A;  2QVE A;  4NLE A;  1Y2M A;  1GKM A;  5EYT A;  1FUQ A;  4FLC A;  1JSW A;  4V2R A;  1U16 A;  2PTS A;  1VDK A;  3E04 A;  2HVG A;  4NSL A;  3RD8 A;  1K7W A;  1C3C A;  3OCF A;  4C6G A;  4C5R A;  3QBP A;  2RJS A;  4C5U A;  5F91 A;  2O6Y A;  2E9F A;  2YII A;  1HY1 A;  3GTD A;  2NYF A;  1J3U A;  4C5S A;  1TJV A;  2O78 A;  1YFE A;  1K62 A;  4EEI A;  1TJU A;  4EFC A;  1RE5 A;  3NZ4 A;  2J91 A;  2FUS A;  3OCE A;  4ADM A;  3RRP A;  5D6B A;  3CZO A;  1DOF A;  2RJR A;  3TV2 A;  1FUR A;  2VD6 A;  2OHY A;  2O7B A;  4BAA A;  3KDZ A;  1GKJ A; 
#chains in the Genus database with same CATH topology
 1XWO A;  1GKJ A;  2PFM A;  2VK9 A;  2O7E A;  1YNN D;  2FEL A;  2LKM B;  4V2Q A;  5IZ2 A;  1TJ7 A;  3LR8 A;  2A68 D;  2PTQ A;  4ADL A;  1B8F A;  2MX8 A;  1EZA A;  3GZH A;  4HGV A;  5HW2 A;  2CW0 D;  3GTG A;  1AUW A;  3R6V A;  2EZA A;  2O7F A;  3GTM A;  1TWA A;  2FIO A;  3LR2 A;  1WCM A;  1YFM A;  1YIS A;  4FFX A;  1EZB A;  1T6J A;  1GK3 A;  4MX2 A;  1I6V D;  3LRD A;  1GK2 A;  4C2M A;  1YNJ D;  2N3E A;  1TWC A;  1I3Q A;  1C3U A;  1HY0 A;  2QGA B;  1W27 A;  3NO9 A;  3R6Q A;  4A15 A;  4CEH A;  3U44 A;  3C8T A;  1TWF A;  3UNV A;  1EB4 A;  5M0J A;  1I0A A;  2HWG A;  1TJW A;  2K3N A;  4QIW A;  1DCN A;  2JA6 A;  3BHG A;  5EYV A;  2LPI A;  1FUO A;  1FUP A;  3EZA A;  1XL7 A;  4APA A;  3KDY A;  1KQ7 A;  2NYN A;  4APB A;  2X75 A;  5F92 A;  2LTH A;  1ZYR D;  4BAB A;  1I50 A;  3H0G A;  4CQ5 A;  2YU9 A;  2O7D A;  2O5J D;  2JA5 A;  1U15 A;  5F91 A;  3R6Y A;  5M0I A;  2VSF A;  2MP0 A;  3LR6 A;  1Q5N A;  2B63 A;  1T6P A;  2PTR A;  1XLY A;  2E2I A;  1ZYM A;  2QVE A;  1Y1W A;  4NLE A;  1Y2M A;  2AQL A;  1GKM A;  5EYT A;  1FUQ A;  2N1D B;  4FLC A;  2X0Q A;  2FEN A;  1IW7 D;  2EZC A;  4WNL A;  1JSW A;  1SMY D;  2R93 A;  4V2R A;  1U16 A;  2LPJ A;  4CEI A;  2PTS A;  1VDK A;  3E04 A;  3FKI A;  2K3O A;  3GTJ A;  2HVG A;  3GTP A;  1Y1V A;  4NSL A;  3RD8 A;  1K7W A;  1C3C A;  1XL8 A;  1TWG A;  2A6H D;  3OCF A;  2BE5 D;  4C6G A;  3GTL A;  4C5R A;  3GTQ A;  3QBP A;  3U4Q A;  2RJS A;  4C5U A;  5H8W A;  2EZB A;  1SFO A;  2R92 A;  2NVX A;  2YII A;  1HY1 A;  2E9F A;  2O6Y A;  3GTK A;  3GTD A;  3KDZ A;  2A69 D;  2F5J A;  2LYI A;  2NYF A;  1J3U A;  2NVY A;  1K83 A;  3GTO A;  4C5S A;  1TJV A;  2VUM A;  2O78 A;  2X0P A;  2JA7 A;  1YFE A;  3CQZ A;  1K62 A;  3EZE A;  1R9T A;  4CEJ A;  4EEI A;  3CRW 1;  2MQA A;  1TJU A;  2Y0N A;  4EFC A;  1RE5 A;  2MX9 A;  3NZ4 A;  2J91 A;  1TWH A;  2FUS A;  2X0O A;  2R7Z A;  2FIP A;  3OCE A;  2HRO A;  4ADM A;  1XMD A;  3CRV A;  3RRP A;  5D6B A;  3CZO A;  1DOF A;  3EZB A;  2RJR A;  3TV2 A;  2K3Q A;  1HQM D;  1FUR A;  2VD6 A;  2OHY A;  2O7B A;  4BAA A;  1XMC A;  2E2H A;  2VL7 A;  4FBS A;  2A6E D; 
#chains in the Genus database with same CATH homology
 1XWO A;  2PFM A;  2O7E A;  1TJ7 A;  4V2Q A;  2PTQ A;  4ADL A;  1B8F A;  3GZH A;  5HW2 A;  4HGV A;  1AUW A;  3R6V A;  2O7F A;  1YFM A;  1YIS A;  4FFX A;  1T6J A;  1GK3 A;  4MX2 A;  1GK2 A;  1C3U A;  3R6Q A;  1HY0 A;  2QGA B;  1W27 A;  3NO9 A;  3C8T A;  3UNV A;  1EB4 A;  1I0A A;  1TJW A;  1DCN A;  4APA A;  3BHG A;  5EYV A;  1FUO A;  1FUP A;  4APB A;  3KDY A;  1KQ7 A;  2NYN A;  2X75 A;  5F92 A;  4BAB A;  4CQ5 A;  2O7D A;  1U15 A;  3R6Y A;  1Q5N A;  1T6P A;  2PTR A;  2QVE A;  4NLE A;  1Y2M A;  1GKM A;  5EYT A;  1FUQ A;  4FLC A;  1JSW A;  4V2R A;  1U16 A;  2PTS A;  1VDK A;  3E04 A;  2HVG A;  4NSL A;  3RD8 A;  1K7W A;  1C3C A;  3OCF A;  4C6G A;  4C5R A;  3QBP A;  2RJS A;  4C5U A;  5F91 A;  2O6Y A;  2E9F A;  2YII A;  1HY1 A;  3GTD A;  2NYF A;  1J3U A;  4C5S A;  1TJV A;  2O78 A;  1YFE A;  1K62 A;  4EEI A;  1TJU A;  4EFC A;  1RE5 A;  3NZ4 A;  2J91 A;  2FUS A;  3OCE A;  4ADM A;  3RRP A;  5D6B A;  3CZO A;  1DOF A;  2RJR A;  3TV2 A;  1FUR A;  2VD6 A;  2OHY A;  2O7B A;  4BAA A;  3KDZ A;  1GKJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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