4C5UA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 255
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
255
sequence length
669
structure length
641
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTKVDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSASGDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRAALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHKDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE
total genus 255
structure length 641
sequence length 669
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c5uA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c5uA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c5uA02
3R6YA 2RJSA 4EFCA 5F91A 1Y2MA 4FLCA 4NSLA 2QVEA 1YFMA 1U15A 2NYNA 4MX2A 1T6JA 1XWOA 4APBA 2X75A 1GKMA 2RJRA 5D6BA 1Q5NA 1YISA 2PTRA 1DCNA 4BAAA 1HY1A 1C3CA 3RRPA 5EYVA 3OCEA 1EB4A 4C5RA 1RE5A 1J3UA 3R6QA 4V2QA 1T6PA 1C3UA 2HVGA 4C5UA 2O7DA 4ADMA 1YFEA 2O78A 1AUWA 1GK3A 3OCFA 4APAA 3QBPA 2O7FA 1TJWA 2O7BA 1W27A 2O7EA 4C6GA 1FURA 2OHYA 1K7WA 1TJVA 2PFMA 4BABA 1FUOA 3BHGA 3UNVA 1HY0A 3KDYA 1DOFA 4V2RA 1I0AA 4HGVA 1U16A 3RD8A 2J91A 2VD6A 1TJUA 1TJ7A 1JSWA 1KQ7A 2O6YA 1GKJA 3E04A 4C5SA 1FUPA 3NZ4A 1VDKA 5EYTA 3CZOA 5HW2A 2YIIA 3KDZA 1K62A 3C8TA 4ADLA 2PTQA 3GZHA 3NO9A 4CQ5A 3TV2A 2PTSA 1B8FA 3R6VA 4EEIA 5F92A 3GTDA 2NYFA 1FUQA 2FUSA 2E9FA 2QGAB 1GK2A 4FFXA 4NLEA
chains in the Genus database with same CATH superfamily
3R6YA 3LR6A 2RJSA 2LPIA 2A68D 2FIPA 4EFCA 2A6HD 5F91A 1Y2MA 3EZEA 5IZ2A 2K3OA 1TWGA 2B63A 2AQLA 2QVEA 4FLCA 2MP0A 1YFMA 4NSLA 2E2IA 4CEHA 2EZCA 1U15A 2NYNA 4MX2A 2YU9A 2NVYA 1T6JA 1TWAA 1XWOA 1K83A 2EZBA 1I6VD 2X75A 4APBA 4QIWA 2HROA 1GKMA 2RJRA 2CW0D 5D6BA 1Q5NA 1YISA 2PTRA 1DCNA 2E2HA 2JA7A 4BAAA 1HY1A 1C3CA 2LYIA 3RRPA 5EYVA 1TWCA 2VK9A 1EZBA 3OCEA 2X0OA 2VUMA 1EB4A 2HWGA 3EZBA 2F5JA 4C5RA 3LR8A 2FELA 1WCMA 1RE5A 1J3UA 3R6QA 1T6PA 4V2QA 1C3UA 2N1DB 2O5JD 1Y1WA 2HVGA 1IW7D 4C5UA 2O7DA 4ADMA 1YFEA 2O78A 2Y0NA 1AUWA 4CEJA 1GK3A 3OCFA 3QBPA 4APAA 2O7FA 1TJWA 2O7BA 1YNND 1W27A 2X0QA 3GTOA 2NVXA 3GTMA 1SMYD 1R9TA 2N3EA 1I50A 2O7EA 4C6GA 1FURA 2EZAA 2OHYA 1K7WA 1TJVA 3CQZA 2PFMA 4BABA 2A6ED 1TWFA 1XL8A 2A69D 1FUOA 1XLYA 3GTPA 1XL7A 1SFOA 2R7ZA 2VL7A 3BHGA 4C2MA 3UNVA 1HY0A 3KDYA 5M0IA 4FBSA 1DOFA 1YNJD 4V2RA 1ZYRD 2MX9A 4CEIA 3LR2A 3U4QA 1I0AA 4HGVA 2R92A 1U16A 3RD8A 2J91A 3CRW1 2LKMB 2VD6A 3GTKA 1TJUA 1HQMD 1TJ7A 1JSWA 1KQ7A 3GTGA 2O6YA 1GKJA 3E04A 2FENA 4C5SA 1FUPA 3NZ4A 1VDKA 4A15A 5EYTA 1ZYMA 2LPJA 3GTQA 3CZOA 5HW2A 3GTJA 2K3NA 1Y1VA 3GTLA 2JA5A 2MQAA 2BE5D 2YIIA 3KDZA 2MX8A 1K62A 3C8TA 2R93A 4ADLA 3EZAA 2PTQA 3LRDA 3CRVA 3GZHA 3NO9A 5M0JA 1EZAA 4CQ5A 3TV2A 3U44A 2PTSA 3FKIA 1B8FA 4WNLA 2FIOA 3R6VA 4EEIA 5F92A 3GTDA 2NYFA 1FUQA 2FUSA 2X0PA 2K3QA 2E9FA 2QGAB 1XMDA 5H8WA 2JA6A 3H0GA 2LTHA 1I3QA 1GK2A 1TWHA 1XMCA 4FFXA 4NLEA 2VSFA
chains in the Genus database with same CATH topology
3R6YA 2RJSA 4EFCA 5F91A 1Y2MA 4FLCA 4NSLA 2QVEA 1YFMA 1U15A 2NYNA 4MX2A 1T6JA 1XWOA 4APBA 2X75A 1GKMA 2RJRA 5D6BA 1Q5NA 1YISA 2PTRA 1DCNA 4BAAA 1HY1A 1C3CA 3RRPA 5EYVA 3OCEA 1EB4A 4C5RA 1RE5A 1J3UA 3R6QA 4V2QA 1T6PA 1C3UA 2HVGA 4C5UA 2O7DA 4ADMA 1YFEA 2O78A 1AUWA 1GK3A 3OCFA 4APAA 3QBPA 2O7FA 1TJWA 2O7BA 1W27A 2O7EA 4C6GA 1FURA 2OHYA 1K7WA 1TJVA 2PFMA 4BABA 1FUOA 3BHGA 3UNVA 1HY0A 3KDYA 1DOFA 4V2RA 1I0AA 4HGVA 1U16A 3RD8A 2J91A 2VD6A 1TJUA 1TJ7A 1JSWA 1KQ7A 2O6YA 1GKJA 3E04A 4C5SA 1FUPA 3NZ4A 1VDKA 5EYTA 3CZOA 5HW2A 2YIIA 3KDZA 1K62A 3C8TA 4ADLA 2PTQA 3GZHA 3NO9A 4CQ5A 3TV2A 2PTSA 1B8FA 3R6VA 4EEIA 5F92A 3GTDA 2NYFA 1FUQA 2FUSA 2E9FA 2QGAB 1GK2A 4FFXA 4NLEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3R6Y A;  2RJS A;  4EFC A;  5F91 A;  1Y2M A;  4FLC A;  4NSL A;  2QVE A;  1YFM A;  1U15 A;  2NYN A;  4MX2 A;  1T6J A;  1XWO A;  4APB A;  2X75 A;  1GKM A;  2RJR A;  5D6B A;  1Q5N A;  1YIS A;  2PTR A;  1DCN A;  4BAA A;  1HY1 A;  1C3C A;  3RRP A;  5EYV A;  3OCE A;  1EB4 A;  4C5R A;  1RE5 A;  1J3U A;  3R6Q A;  4V2Q A;  1T6P A;  1C3U A;  2HVG A;  4C5U A;  2O7D A;  4ADM A;  1YFE A;  2O78 A;  1AUW A;  1GK3 A;  3OCF A;  4APA A;  3QBP A;  2O7F A;  1TJW A;  2O7B A;  1W27 A;  2O7E A;  4C6G A;  1FUR A;  2OHY A;  1K7W A;  1TJV A;  2PFM A;  4BAB A;  1FUO A;  3BHG A;  3UNV A;  1HY0 A;  3KDY A;  1DOF A;  4V2R A;  1I0A A;  4HGV A;  1U16 A;  3RD8 A;  2J91 A;  2VD6 A;  1TJU A;  1TJ7 A;  1JSW A;  1KQ7 A;  2O6Y A;  1GKJ A;  3E04 A;  4C5S A;  1FUP A;  3NZ4 A;  1VDK A;  5EYT A;  3CZO A;  5HW2 A;  2YII A;  3KDZ A;  1K62 A;  3C8T A;  4ADL A;  2PTQ A;  3GZH A;  3NO9 A;  4CQ5 A;  3TV2 A;  2PTS A;  1B8F A;  3R6V A;  4EEI A;  5F92 A;  3GTD A;  2NYF A;  1FUQ A;  2FUS A;  2E9F A;  2QGA B;  1GK2 A;  4FFX A;  4NLE A; 
#chains in the Genus database with same CATH topology
 3R6Y A;  3LR6 A;  2RJS A;  2LPI A;  2A68 D;  2FIP A;  4EFC A;  2A6H D;  5F91 A;  1Y2M A;  3EZE A;  5IZ2 A;  2K3O A;  1TWG A;  2B63 A;  2AQL A;  2QVE A;  4FLC A;  2MP0 A;  1YFM A;  4NSL A;  2E2I A;  4CEH A;  2EZC A;  1U15 A;  2NYN A;  4MX2 A;  2YU9 A;  2NVY A;  1T6J A;  1TWA A;  1XWO A;  1K83 A;  2EZB A;  1I6V D;  2X75 A;  4APB A;  4QIW A;  2HRO A;  1GKM A;  2RJR A;  2CW0 D;  5D6B A;  1Q5N A;  1YIS A;  2PTR A;  1DCN A;  2E2H A;  2JA7 A;  4BAA A;  1HY1 A;  1C3C A;  2LYI A;  3RRP A;  5EYV A;  1TWC A;  2VK9 A;  1EZB A;  3OCE A;  2X0O A;  2VUM A;  1EB4 A;  2HWG A;  3EZB A;  2F5J A;  4C5R A;  3LR8 A;  2FEL A;  1WCM A;  1RE5 A;  1J3U A;  3R6Q A;  1T6P A;  4V2Q A;  1C3U A;  2N1D B;  2O5J D;  1Y1W A;  2HVG A;  1IW7 D;  4C5U A;  2O7D A;  4ADM A;  1YFE A;  2O78 A;  2Y0N A;  1AUW A;  4CEJ A;  1GK3 A;  3OCF A;  3QBP A;  4APA A;  2O7F A;  1TJW A;  2O7B A;  1YNN D;  1W27 A;  2X0Q A;  3GTO A;  2NVX A;  3GTM A;  1SMY D;  1R9T A;  2N3E A;  1I50 A;  2O7E A;  4C6G A;  1FUR A;  2EZA A;  2OHY A;  1K7W A;  1TJV A;  3CQZ A;  2PFM A;  4BAB A;  2A6E D;  1TWF A;  1XL8 A;  2A69 D;  1FUO A;  1XLY A;  3GTP A;  1XL7 A;  1SFO A;  2R7Z A;  2VL7 A;  3BHG A;  4C2M A;  3UNV A;  1HY0 A;  3KDY A;  5M0I A;  4FBS A;  1DOF A;  1YNJ D;  4V2R A;  1ZYR D;  2MX9 A;  4CEI A;  3LR2 A;  3U4Q A;  1I0A A;  4HGV A;  2R92 A;  1U16 A;  3RD8 A;  2J91 A;  3CRW 1;  2LKM B;  2VD6 A;  3GTK A;  1TJU A;  1HQM D;  1TJ7 A;  1JSW A;  1KQ7 A;  3GTG A;  2O6Y A;  1GKJ A;  3E04 A;  2FEN A;  4C5S A;  1FUP A;  3NZ4 A;  1VDK A;  4A15 A;  5EYT A;  1ZYM A;  2LPJ A;  3GTQ A;  3CZO A;  5HW2 A;  3GTJ A;  2K3N A;  1Y1V A;  3GTL A;  2JA5 A;  2MQA A;  2BE5 D;  2YII A;  3KDZ A;  2MX8 A;  1K62 A;  3C8T A;  2R93 A;  4ADL A;  3EZA A;  2PTQ A;  3LRD A;  3CRV A;  3GZH A;  3NO9 A;  5M0J A;  1EZA A;  4CQ5 A;  3TV2 A;  3U44 A;  2PTS A;  3FKI A;  1B8F A;  4WNL A;  2FIO A;  3R6V A;  4EEI A;  5F92 A;  3GTD A;  2NYF A;  1FUQ A;  2FUS A;  2X0P A;  2K3Q A;  2E9F A;  2QGA B;  1XMD A;  5H8W A;  2JA6 A;  3H0G A;  2LTH A;  1I3Q A;  1GK2 A;  1TWH A;  1XMC A;  4FFX A;  4NLE A;  2VSF A; 
#chains in the Genus database with same CATH homology
 3R6Y A;  2RJS A;  4EFC A;  5F91 A;  1Y2M A;  4FLC A;  4NSL A;  2QVE A;  1YFM A;  1U15 A;  2NYN A;  4MX2 A;  1T6J A;  1XWO A;  4APB A;  2X75 A;  1GKM A;  2RJR A;  5D6B A;  1Q5N A;  1YIS A;  2PTR A;  1DCN A;  4BAA A;  1HY1 A;  1C3C A;  3RRP A;  5EYV A;  3OCE A;  1EB4 A;  4C5R A;  1RE5 A;  1J3U A;  3R6Q A;  4V2Q A;  1T6P A;  1C3U A;  2HVG A;  4C5U A;  2O7D A;  4ADM A;  1YFE A;  2O78 A;  1AUW A;  1GK3 A;  3OCF A;  4APA A;  3QBP A;  2O7F A;  1TJW A;  2O7B A;  1W27 A;  2O7E A;  4C6G A;  1FUR A;  2OHY A;  1K7W A;  1TJV A;  2PFM A;  4BAB A;  1FUO A;  3BHG A;  3UNV A;  1HY0 A;  3KDY A;  1DOF A;  4V2R A;  1I0A A;  4HGV A;  1U16 A;  3RD8 A;  2J91 A;  2VD6 A;  1TJU A;  1TJ7 A;  1JSW A;  1KQ7 A;  2O6Y A;  1GKJ A;  3E04 A;  4C5S A;  1FUP A;  3NZ4 A;  1VDK A;  5EYT A;  3CZO A;  5HW2 A;  2YII A;  3KDZ A;  1K62 A;  3C8T A;  4ADL A;  2PTQ A;  3GZH A;  3NO9 A;  4CQ5 A;  3TV2 A;  2PTS A;  1B8F A;  3R6V A;  4EEI A;  5F92 A;  3GTD A;  2NYF A;  1FUQ A;  2FUS A;  2E9F A;  2QGA B;  1GK2 A;  4FFX A;  4NLE A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...