4C5UA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 255
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
255
sequence length
669
structure length
641
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTKVDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSASGDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRAALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHKDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE
publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
total genus 255
structure length 641
sequence length 669
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c5uA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c5uA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c5uA02
2QVEA 3NZ4A 2RJSA 5EYTA 1FUQA 1C3UA 1TJVA 4APAA 1TJ7A 3R6VA 1C3CA 1GK3A 3R6YA 1T6JA 2NYNA 2O7FA 4EEIA 1TJWA 2NYFA 3C8TA 1FUPA 1FURA 5HW2A 4C5SA 1YFEA 4FLCA 2RJRA 3KDYA 4FFXA 2O6YA 2O7BA 4HGVA 2E9FA 2VD6A 4ADMA 2PFMA 1U16A 1HY1A 1DCNA 2PTRA 3GZHA 4C5UA 3BHGA 3OCEA 4MX2A 3R6QA 2FUSA 2J91A 1GKJA 3RD8A 1J3UA 3QBPA 2O78A 4ADLA 2O7EA 1GK2A 4BABA 2HVGA 3TV2A 4APBA 1YFMA 2QGAB 3CZOA 5F92A 1VDKA 1XWOA 1EB4A 1K62A 3KDZA 1B8FA 1K7WA 1AUWA 1Q5NA 1YISA 4C6GA 2PTQA 4CQ5A 1T6PA 2YIIA 1GKMA 1TJUA 4NSLA 4EFCA 4NLEA 3OCFA 2X75A 1Y2MA 4BAAA 5F91A 1I0AA 1RE5A 4V2QA 3GTDA 3RRPA 4V2RA 1HY0A 1JSWA 5EYVA 2O7DA 2PTSA 3UNVA 2OHYA 1KQ7A 1W27A 3E04A 1U15A 1FUOA 5D6BA 3NO9A 1DOFA 4C5RA
chains in the Genus database with same CATH superfamily
2QVEA 3U4QA 2CW0D 3U44A 3NZ4A 2RJSA 3EZAA 1SFOA 2E2IA 5EYTA 1FUQA 5M0JA 2A6HD 3EZEA 3CQZA 1C3UA 1TJVA 4APAA 2Y0NA 1TJ7A 4WNLA 2R7ZA 3R6VA 2X0OA 1C3CA 2MQAA 1GK3A 3R6YA 1T6JA 2NYNA 2O7FA 4EEIA 1TJWA 2NYFA 3C8TA 1TWAA 1FUPA 2LKMB 2K3NA 2MX8A 1FURA 5HW2A 2HWGA 4C5SA 2VL7A 2LPIA 1YFEA 1WCMA 3EZBA 4FLCA 2RJRA 3KDYA 4FFXA 2O6YA 2O7BA 4HGVA 2X0PA 2E9FA 2VD6A 1TWHA 2VUMA 3LR2A 4ADMA 2PFMA 3LR8A 2LTHA 1U16A 1XMDA 2R93A 1DCNA 1HY1A 2PTRA 3CRW1 3GZHA 4C5UA 5IZ2A 2N3EA 3BHGA 3OCEA 1HQMD 2LYIA 2FUSA 2J91A 4MX2A 3R6QA 2JA6A 1GKJA 1R9TA 2X0QA 1J3UA 3RD8A 3QBPA 3GTJA 1I3QA 2O78A 4ADLA 2FELA 1TWFA 1ZYMA 2FENA 2O7EA 1GK2A 3GTGA 4CEIA 2E2HA 2HROA 4BABA 2HVGA 2F5JA 3TV2A 1TWCA 3GTKA 4APBA 1K83A 2MP0A 1Y1VA 1EZAA 2NVYA 1XL8A 1YFMA 2QGAB 4C2MA 2NVXA 1XMCA 3CZOA 5F92A 1VDKA 3GTPA 1XWOA 1EB4A 4QIWA 3GTLA 1Y1WA 2VSFA 3LR6A 3GTMA 1I50A 2A6ED 2K3OA 1I6VD 1K62A 3KDZA 1B8FA 1K7WA 1AUWA 2B63A 3GTQA 2FIOA 3FKIA 2O5JD 1Q5NA 4CEHA 2EZAA 4C6GA 1YISA 2PTQA 4CQ5A 1ZYRD 1T6PA 2YIIA 2A69D 1GKMA 1EZBA 1TJUA 1YNND 4NLEA 4NSLA 3OCFA 4EFCA 2EZCA 1Y2MA 2X75A 4BAAA 5F91A 1I0AA 2JA7A 1XLYA 2EZBA 1RE5A 1XL7A 4V2QA 2A68D 3GTDA 1IW7D 3RRPA 3LRDA 4V2RA 1HY0A 5M0IA 1JSWA 2N1DB 4CEJA 5EYVA 1YNJD 2VK9A 2O7DA 2LPJA 2PTSA 3GTOA 2BE5D 3UNVA 2K3QA 4FBSA 2OHYA 2R92A 1W27A 1KQ7A 2FIPA 3E04A 1U15A 2YU9A 3CRVA 1FUOA 5D6BA 2MX9A 3H0GA 4A15A 1SMYD 2JA5A 3NO9A 5H8WA 2AQLA 1DOFA 4C5RA 1TWGA
chains in the Genus database with same CATH topology
2QVEA 3NZ4A 2RJSA 5EYTA 1FUQA 1C3UA 1TJVA 4APAA 1TJ7A 3R6VA 1C3CA 1GK3A 3R6YA 1T6JA 2NYNA 2O7FA 4EEIA 1TJWA 2NYFA 3C8TA 1FUPA 1FURA 5HW2A 4C5SA 1YFEA 4FLCA 2RJRA 3KDYA 4FFXA 2O6YA 2O7BA 4HGVA 2E9FA 2VD6A 4ADMA 2PFMA 1U16A 1HY1A 1DCNA 2PTRA 3GZHA 4C5UA 3BHGA 3OCEA 4MX2A 3R6QA 2FUSA 2J91A 1GKJA 3RD8A 1J3UA 3QBPA 2O78A 4ADLA 2O7EA 1GK2A 4BABA 2HVGA 3TV2A 4APBA 1YFMA 2QGAB 3CZOA 5F92A 1VDKA 1XWOA 1EB4A 1K62A 3KDZA 1B8FA 1K7WA 1AUWA 1Q5NA 1YISA 4C6GA 2PTQA 4CQ5A 1T6PA 2YIIA 1GKMA 1TJUA 4NSLA 4EFCA 4NLEA 3OCFA 2X75A 1Y2MA 4BAAA 5F91A 1I0AA 1RE5A 4V2QA 3GTDA 3RRPA 4V2RA 1HY0A 1JSWA 5EYVA 2O7DA 2PTSA 3UNVA 2OHYA 1KQ7A 1W27A 3E04A 1U15A 1FUOA 5D6BA 3NO9A 1DOFA 4C5RA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2QVE A;  3NZ4 A;  2RJS A;  5EYT A;  1FUQ A;  1C3U A;  1TJV A;  4APA A;  1TJ7 A;  3R6V A;  1C3C A;  1GK3 A;  3R6Y A;  1T6J A;  2NYN A;  2O7F A;  4EEI A;  1TJW A;  2NYF A;  3C8T A;  1FUP A;  1FUR A;  5HW2 A;  4C5S A;  1YFE A;  4FLC A;  2RJR A;  3KDY A;  4FFX A;  2O6Y A;  2O7B A;  4HGV A;  2E9F A;  2VD6 A;  4ADM A;  2PFM A;  1U16 A;  1HY1 A;  1DCN A;  2PTR A;  3GZH A;  4C5U A;  3BHG A;  3OCE A;  4MX2 A;  3R6Q A;  2FUS A;  2J91 A;  1GKJ A;  3RD8 A;  1J3U A;  3QBP A;  2O78 A;  4ADL A;  2O7E A;  1GK2 A;  4BAB A;  2HVG A;  3TV2 A;  4APB A;  1YFM A;  2QGA B;  3CZO A;  5F92 A;  1VDK A;  1XWO A;  1EB4 A;  1K62 A;  3KDZ A;  1B8F A;  1K7W A;  1AUW A;  1Q5N A;  1YIS A;  4C6G A;  2PTQ A;  4CQ5 A;  1T6P A;  2YII A;  1GKM A;  1TJU A;  4NSL A;  4EFC A;  4NLE A;  3OCF A;  2X75 A;  1Y2M A;  4BAA A;  5F91 A;  1I0A A;  1RE5 A;  4V2Q A;  3GTD A;  3RRP A;  4V2R A;  1HY0 A;  1JSW A;  5EYV A;  2O7D A;  2PTS A;  3UNV A;  2OHY A;  1KQ7 A;  1W27 A;  3E04 A;  1U15 A;  1FUO A;  5D6B A;  3NO9 A;  1DOF A;  4C5R A; 
#chains in the Genus database with same CATH topology
 2QVE A;  3U4Q A;  2CW0 D;  3U44 A;  3NZ4 A;  2RJS A;  3EZA A;  1SFO A;  2E2I A;  5EYT A;  1FUQ A;  5M0J A;  2A6H D;  3EZE A;  3CQZ A;  1C3U A;  1TJV A;  4APA A;  2Y0N A;  1TJ7 A;  4WNL A;  2R7Z A;  3R6V A;  2X0O A;  1C3C A;  2MQA A;  1GK3 A;  3R6Y A;  1T6J A;  2NYN A;  2O7F A;  4EEI A;  1TJW A;  2NYF A;  3C8T A;  1TWA A;  1FUP A;  2LKM B;  2K3N A;  2MX8 A;  1FUR A;  5HW2 A;  2HWG A;  4C5S A;  2VL7 A;  2LPI A;  1YFE A;  1WCM A;  3EZB A;  4FLC A;  2RJR A;  3KDY A;  4FFX A;  2O6Y A;  2O7B A;  4HGV A;  2X0P A;  2E9F A;  2VD6 A;  1TWH A;  2VUM A;  3LR2 A;  4ADM A;  2PFM A;  3LR8 A;  2LTH A;  1U16 A;  1XMD A;  2R93 A;  1DCN A;  1HY1 A;  2PTR A;  3CRW 1;  3GZH A;  4C5U A;  5IZ2 A;  2N3E A;  3BHG A;  3OCE A;  1HQM D;  2LYI A;  2FUS A;  2J91 A;  4MX2 A;  3R6Q A;  2JA6 A;  1GKJ A;  1R9T A;  2X0Q A;  1J3U A;  3RD8 A;  3QBP A;  3GTJ A;  1I3Q A;  2O78 A;  4ADL A;  2FEL A;  1TWF A;  1ZYM A;  2FEN A;  2O7E A;  1GK2 A;  3GTG A;  4CEI A;  2E2H A;  2HRO A;  4BAB A;  2HVG A;  2F5J A;  3TV2 A;  1TWC A;  3GTK A;  4APB A;  1K83 A;  2MP0 A;  1Y1V A;  1EZA A;  2NVY A;  1XL8 A;  1YFM A;  2QGA B;  4C2M A;  2NVX A;  1XMC A;  3CZO A;  5F92 A;  1VDK A;  3GTP A;  1XWO A;  1EB4 A;  4QIW A;  3GTL A;  1Y1W A;  2VSF A;  3LR6 A;  3GTM A;  1I50 A;  2A6E D;  2K3O A;  1I6V D;  1K62 A;  3KDZ A;  1B8F A;  1K7W A;  1AUW A;  2B63 A;  3GTQ A;  2FIO A;  3FKI A;  2O5J D;  1Q5N A;  4CEH A;  2EZA A;  4C6G A;  1YIS A;  2PTQ A;  4CQ5 A;  1ZYR D;  1T6P A;  2YII A;  2A69 D;  1GKM A;  1EZB A;  1TJU A;  1YNN D;  4NLE A;  4NSL A;  3OCF A;  4EFC A;  2EZC A;  1Y2M A;  2X75 A;  4BAA A;  5F91 A;  1I0A A;  2JA7 A;  1XLY A;  2EZB A;  1RE5 A;  1XL7 A;  4V2Q A;  2A68 D;  3GTD A;  1IW7 D;  3RRP A;  3LRD A;  4V2R A;  1HY0 A;  5M0I A;  1JSW A;  2N1D B;  4CEJ A;  5EYV A;  1YNJ D;  2VK9 A;  2O7D A;  2LPJ A;  2PTS A;  3GTO A;  2BE5 D;  3UNV A;  2K3Q A;  4FBS A;  2OHY A;  2R92 A;  1W27 A;  1KQ7 A;  2FIP A;  3E04 A;  1U15 A;  2YU9 A;  3CRV A;  1FUO A;  5D6B A;  2MX9 A;  3H0G A;  4A15 A;  1SMY D;  2JA5 A;  3NO9 A;  5H8W A;  2AQL A;  1DOF A;  4C5R A;  1TWG A; 
#chains in the Genus database with same CATH homology
 2QVE A;  3NZ4 A;  2RJS A;  5EYT A;  1FUQ A;  1C3U A;  1TJV A;  4APA A;  1TJ7 A;  3R6V A;  1C3C A;  1GK3 A;  3R6Y A;  1T6J A;  2NYN A;  2O7F A;  4EEI A;  1TJW A;  2NYF A;  3C8T A;  1FUP A;  1FUR A;  5HW2 A;  4C5S A;  1YFE A;  4FLC A;  2RJR A;  3KDY A;  4FFX A;  2O6Y A;  2O7B A;  4HGV A;  2E9F A;  2VD6 A;  4ADM A;  2PFM A;  1U16 A;  1HY1 A;  1DCN A;  2PTR A;  3GZH A;  4C5U A;  3BHG A;  3OCE A;  4MX2 A;  3R6Q A;  2FUS A;  2J91 A;  1GKJ A;  3RD8 A;  1J3U A;  3QBP A;  2O78 A;  4ADL A;  2O7E A;  1GK2 A;  4BAB A;  2HVG A;  3TV2 A;  4APB A;  1YFM A;  2QGA B;  3CZO A;  5F92 A;  1VDK A;  1XWO A;  1EB4 A;  1K62 A;  3KDZ A;  1B8F A;  1K7W A;  1AUW A;  1Q5N A;  1YIS A;  4C6G A;  2PTQ A;  4CQ5 A;  1T6P A;  2YII A;  1GKM A;  1TJU A;  4NSL A;  4EFC A;  4NLE A;  3OCF A;  2X75 A;  1Y2M A;  4BAA A;  5F91 A;  1I0A A;  1RE5 A;  4V2Q A;  3GTD A;  3RRP A;  4V2R A;  1HY0 A;  1JSW A;  5EYV A;  2O7D A;  2PTS A;  3UNV A;  2OHY A;  1KQ7 A;  1W27 A;  3E04 A;  1U15 A;  1FUO A;  5D6B A;  3NO9 A;  1DOF A;  4C5R A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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