4C5UA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 255
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
255
sequence length
669
structure length
641
Chain Sequence
b'SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTKVDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSASGDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRAALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHKDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMMONIA-LYASE
publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 255
structure length 641
sequence length 669
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c5uA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c5uA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c5uA02
1GK2A 4FLCA 3R6QA 3RRPA 3OCEA 5EYTA 1VDKA 4NLEA 5EYVA 2O7FA 2NYFA 1DOFA 2O7BA 1GKMA 1T6JA 1HY1A 1K7WA 2O78A 3BHGA 2E9FA 2RJSA 3OCFA 4MX2A 2PFMA 1T6PA 5F91A 4BAAA 1U16A 1FUPA 3KDYA 4C5UA 1W27A 2VD6A 2O7EA 5HW2A 1RE5A 2O7DA 3TV2A 3NO9A 2OHYA 1YISA 1C3UA 4CQ5A 3R6YA 4APAA 2RJRA 2NYNA 1TJUA 3GZHA 4FFXA 1KQ7A 4V2QA 4ADLA 1JSWA 1YFMA 1K62A 4V2RA 2PTSA 1Y2MA 1U15A 1TJ7A 4C5SA 1TJWA 2PTQA 1I0AA 3C8TA 2QGAB 1FUOA 4NSLA 2O6YA 1AUWA 2J91A 4HGVA 1GKJA 2HVGA 3QBPA 5D6BA 1GK3A 4ADMA 1J3UA 3R6VA 3NZ4A 1C3CA 1B8FA 1Q5NA 3CZOA 1EB4A 5F92A 1DCNA 2PTRA 3GTDA 3KDZA 1XWOA 4C6GA 2QVEA 2YIIA 1TJVA 2X75A 4BABA 4C5RA 1FURA 2FUSA 4EFCA 4EEIA 4APBA 1FUQA 3UNVA 1YFEA 3RD8A 3E04A 1HY0A
chains in the Genus database with same CATH superfamily
2A69D 1GK2A 2VL7A 4CEIA 1Y1WA 2LPJA 3LRDA 4FBSA 2LTHA 1YNJD 2A6HD 4FLCA 3R6QA 3RRPA 3OCEA 5EYTA 1VDKA 4NLEA 5EYVA 2O7FA 3GTQA 2VUMA 2NYFA 1DOFA 1XMCA 2O7BA 1GKMA 2A6ED 4CEJA 1T6JA 5M0IA 2F5JA 3GTGA 1I6VD 1HY1A 1K7WA 2O78A 3BHGA 2E9FA 1TWAA 3CRVA 2RJSA 3OCFA 4MX2A 5H8WA 2PFMA 1Y1VA 4A15A 1T6PA 5F91A 4BAAA 1U16A 2AQLA 1FUPA 1EZAA 3FKIA 3LR8A 1XMDA 2MX8A 4C5UA 3KDYA 2N1DB 1TWFA 3EZBA 2FENA 1W27A 2R7ZA 2VD6A 2O7EA 5HW2A 3GTLA 1RE5A 2O7DA 1WCMA 2JA6A 3NO9A 3TV2A 1IW7D 2OHYA 1XLYA 1YISA 1C3UA 1TWCA 4CQ5A 3GTOA 3R6YA 4APAA 5IZ2A 2JA5A 2RJRA 2VK9A 1TWHA 1R9TA 2NYNA 2X0OA 1TJUA 3GZHA 1HQMD 4FFXA 1KQ7A 4V2QA 2E2HA 3GTKA 2K3NA 4ADLA 1JSWA 2MX9A 4QIWA 1K62A 4V2RA 1YFMA 2PTSA 2LYIA 1Y2MA 1YNND 2E2IA 2LPIA 1TJ7A 1U15A 4C5SA 1TJWA 2PTQA 1I0AA 2FELA 1TWGA 3C8TA 2FIPA 2X0QA 4CEHA 2B63A 1SFOA 2QGAB 2Y0NA 1FUOA 4NSLA 2O6YA 1AUWA 2J91A 1SMYD 2R92A 2K3QA 2MQAA 4HGVA 1GKJA 2HVGA 3QBPA 5D6BA 1K83A 1GK3A 3H0GA 4ADMA 2K3OA 2FIOA 4WNLA 2MP0A 2YU9A 2X0PA 2HROA 3U4QA 1J3UA 3R6VA 3NZ4A 1C3CA 1B8FA 3U44A 1Q5NA 1EB4A 3CZOA 1DCNA 5F92A 2N3EA 2BE5D 1ZYMA 2PTRA 2LKMB 3GTDA 1I3QA 1XL8A 3KDZA 3GTJA 2R93A 1XWOA 1XL7A 4C6GA 2QVEA 3CQZA 1I50A 2CW0D 2YIIA 1TJVA 3EZAA 2NVYA 3LR2A 2JA7A 2X75A 4BABA 2A68D 3CRW1 4C5RA 2HWGA 4C2MA 1FURA 2FUSA 1EZBA 2NVXA 2EZBA 2VSFA 4EFCA 3EZEA 5M0JA 4EEIA 4APBA 2O5JD 1FUQA 3UNVA 1YFEA 3LR6A 3RD8A 3GTPA 3E04A 2EZCA 1HY0A 2EZAA 1ZYRD 3GTMA
chains in the Genus database with same CATH topology
1GK2A 4FLCA 3R6QA 3RRPA 3OCEA 5EYTA 1VDKA 4NLEA 5EYVA 2O7FA 2NYFA 1DOFA 2O7BA 1GKMA 1T6JA 1HY1A 1K7WA 2O78A 3BHGA 2E9FA 2RJSA 3OCFA 4MX2A 2PFMA 1T6PA 5F91A 4BAAA 1U16A 1FUPA 3KDYA 4C5UA 1W27A 2VD6A 2O7EA 5HW2A 1RE5A 2O7DA 3TV2A 3NO9A 2OHYA 1YISA 1C3UA 4CQ5A 3R6YA 4APAA 2RJRA 2NYNA 1TJUA 3GZHA 4FFXA 1KQ7A 4V2QA 4ADLA 1JSWA 1YFMA 1K62A 4V2RA 2PTSA 1Y2MA 1U15A 1TJ7A 4C5SA 1TJWA 2PTQA 1I0AA 3C8TA 2QGAB 1FUOA 4NSLA 2O6YA 1AUWA 2J91A 4HGVA 1GKJA 2HVGA 3QBPA 5D6BA 1GK3A 4ADMA 1J3UA 3R6VA 3NZ4A 1C3CA 1B8FA 1Q5NA 3CZOA 1EB4A 5F92A 1DCNA 2PTRA 3GTDA 3KDZA 1XWOA 4C6GA 2QVEA 2YIIA 1TJVA 2X75A 4BABA 4C5RA 1FURA 2FUSA 4EFCA 4EEIA 4APBA 1FUQA 3UNVA 1YFEA 3RD8A 3E04A 1HY0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1GK2 A;  4FLC A;  3R6Q A;  3RRP A;  3OCE A;  5EYT A;  1VDK A;  4NLE A;  5EYV A;  2O7F A;  2NYF A;  1DOF A;  2O7B A;  1GKM A;  1T6J A;  1HY1 A;  1K7W A;  2O78 A;  3BHG A;  2E9F A;  2RJS A;  3OCF A;  4MX2 A;  2PFM A;  1T6P A;  5F91 A;  4BAA A;  1U16 A;  1FUP A;  3KDY A;  4C5U A;  1W27 A;  2VD6 A;  2O7E A;  5HW2 A;  1RE5 A;  2O7D A;  3TV2 A;  3NO9 A;  2OHY A;  1YIS A;  1C3U A;  4CQ5 A;  3R6Y A;  4APA A;  2RJR A;  2NYN A;  1TJU A;  3GZH A;  4FFX A;  1KQ7 A;  4V2Q A;  4ADL A;  1JSW A;  1YFM A;  1K62 A;  4V2R A;  2PTS A;  1Y2M A;  1U15 A;  1TJ7 A;  4C5S A;  1TJW A;  2PTQ A;  1I0A A;  3C8T A;  2QGA B;  1FUO A;  4NSL A;  2O6Y A;  1AUW A;  2J91 A;  4HGV A;  1GKJ A;  2HVG A;  3QBP A;  5D6B A;  1GK3 A;  4ADM A;  1J3U A;  3R6V A;  3NZ4 A;  1C3C A;  1B8F A;  1Q5N A;  3CZO A;  1EB4 A;  5F92 A;  1DCN A;  2PTR A;  3GTD A;  3KDZ A;  1XWO A;  4C6G A;  2QVE A;  2YII A;  1TJV A;  2X75 A;  4BAB A;  4C5R A;  1FUR A;  2FUS A;  4EFC A;  4EEI A;  4APB A;  1FUQ A;  3UNV A;  1YFE A;  3RD8 A;  3E04 A;  1HY0 A; 
#chains in the Genus database with same CATH topology
 2A69 D;  1GK2 A;  2VL7 A;  4CEI A;  1Y1W A;  2LPJ A;  3LRD A;  4FBS A;  2LTH A;  1YNJ D;  2A6H D;  4FLC A;  3R6Q A;  3RRP A;  3OCE A;  5EYT A;  1VDK A;  4NLE A;  5EYV A;  2O7F A;  3GTQ A;  2VUM A;  2NYF A;  1DOF A;  1XMC A;  2O7B A;  1GKM A;  2A6E D;  4CEJ A;  1T6J A;  5M0I A;  2F5J A;  3GTG A;  1I6V D;  1HY1 A;  1K7W A;  2O78 A;  3BHG A;  2E9F A;  1TWA A;  3CRV A;  2RJS A;  3OCF A;  4MX2 A;  5H8W A;  2PFM A;  1Y1V A;  4A15 A;  1T6P A;  5F91 A;  4BAA A;  1U16 A;  2AQL A;  1FUP A;  1EZA A;  3FKI A;  3LR8 A;  1XMD A;  2MX8 A;  4C5U A;  3KDY A;  2N1D B;  1TWF A;  3EZB A;  2FEN A;  1W27 A;  2R7Z A;  2VD6 A;  2O7E A;  5HW2 A;  3GTL A;  1RE5 A;  2O7D A;  1WCM A;  2JA6 A;  3NO9 A;  3TV2 A;  1IW7 D;  2OHY A;  1XLY A;  1YIS A;  1C3U A;  1TWC A;  4CQ5 A;  3GTO A;  3R6Y A;  4APA A;  5IZ2 A;  2JA5 A;  2RJR A;  2VK9 A;  1TWH A;  1R9T A;  2NYN A;  2X0O A;  1TJU A;  3GZH A;  1HQM D;  4FFX A;  1KQ7 A;  4V2Q A;  2E2H A;  3GTK A;  2K3N A;  4ADL A;  1JSW A;  2MX9 A;  4QIW A;  1K62 A;  4V2R A;  1YFM A;  2PTS A;  2LYI A;  1Y2M A;  1YNN D;  2E2I A;  2LPI A;  1TJ7 A;  1U15 A;  4C5S A;  1TJW A;  2PTQ A;  1I0A A;  2FEL A;  1TWG A;  3C8T A;  2FIP A;  2X0Q A;  4CEH A;  2B63 A;  1SFO A;  2QGA B;  2Y0N A;  1FUO A;  4NSL A;  2O6Y A;  1AUW A;  2J91 A;  1SMY D;  2R92 A;  2K3Q A;  2MQA A;  4HGV A;  1GKJ A;  2HVG A;  3QBP A;  5D6B A;  1K83 A;  1GK3 A;  3H0G A;  4ADM A;  2K3O A;  2FIO A;  4WNL A;  2MP0 A;  2YU9 A;  2X0P A;  2HRO A;  3U4Q A;  1J3U A;  3R6V A;  3NZ4 A;  1C3C A;  1B8F A;  3U44 A;  1Q5N A;  1EB4 A;  3CZO A;  1DCN A;  5F92 A;  2N3E A;  2BE5 D;  1ZYM A;  2PTR A;  2LKM B;  3GTD A;  1I3Q A;  1XL8 A;  3KDZ A;  3GTJ A;  2R93 A;  1XWO A;  1XL7 A;  4C6G A;  2QVE A;  3CQZ A;  1I50 A;  2CW0 D;  2YII A;  1TJV A;  3EZA A;  2NVY A;  3LR2 A;  2JA7 A;  2X75 A;  4BAB A;  2A68 D;  3CRW 1;  4C5R A;  2HWG A;  4C2M A;  1FUR A;  2FUS A;  1EZB A;  2NVX A;  2EZB A;  2VSF A;  4EFC A;  3EZE A;  5M0J A;  4EEI A;  4APB A;  2O5J D;  1FUQ A;  3UNV A;  1YFE A;  3LR6 A;  3RD8 A;  3GTP A;  3E04 A;  2EZC A;  1HY0 A;  2EZA A;  1ZYR D;  3GTM A; 
#chains in the Genus database with same CATH homology
 1GK2 A;  4FLC A;  3R6Q A;  3RRP A;  3OCE A;  5EYT A;  1VDK A;  4NLE A;  5EYV A;  2O7F A;  2NYF A;  1DOF A;  2O7B A;  1GKM A;  1T6J A;  1HY1 A;  1K7W A;  2O78 A;  3BHG A;  2E9F A;  2RJS A;  3OCF A;  4MX2 A;  2PFM A;  1T6P A;  5F91 A;  4BAA A;  1U16 A;  1FUP A;  3KDY A;  4C5U A;  1W27 A;  2VD6 A;  2O7E A;  5HW2 A;  1RE5 A;  2O7D A;  3TV2 A;  3NO9 A;  2OHY A;  1YIS A;  1C3U A;  4CQ5 A;  3R6Y A;  4APA A;  2RJR A;  2NYN A;  1TJU A;  3GZH A;  4FFX A;  1KQ7 A;  4V2Q A;  4ADL A;  1JSW A;  1YFM A;  1K62 A;  4V2R A;  2PTS A;  1Y2M A;  1U15 A;  1TJ7 A;  4C5S A;  1TJW A;  2PTQ A;  1I0A A;  3C8T A;  2QGA B;  1FUO A;  4NSL A;  2O6Y A;  1AUW A;  2J91 A;  4HGV A;  1GKJ A;  2HVG A;  3QBP A;  5D6B A;  1GK3 A;  4ADM A;  1J3U A;  3R6V A;  3NZ4 A;  1C3C A;  1B8F A;  1Q5N A;  3CZO A;  1EB4 A;  5F92 A;  1DCN A;  2PTR A;  3GTD A;  3KDZ A;  1XWO A;  4C6G A;  2QVE A;  2YII A;  1TJV A;  2X75 A;  4BAB A;  4C5R A;  1FUR A;  2FUS A;  4EFC A;  4EEI A;  4APB A;  1FUQ A;  3UNV A;  1YFE A;  3RD8 A;  3E04 A;  1HY0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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