3NZ4A

Crystal structure of a taxus phenylalanine aminomutase
Total Genus 257
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
257
sequence length
670
structure length
653
Chain Sequence
SRSHVKDILGLINTFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNQLSELQESLIRCLLAGVFTKGCASSVDELPATVTRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATALASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQDLSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTDEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFGSILALHKETDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSRFLPFYRFVRDELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFLG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Mechanistic, mutational, and structural evaluation of a taxus phenylalanine aminomutase.
pubmed doi rcsb
source organism Taxus canadensis
molecule tags Lyase
molecule keywords Phenylalanine ammonia-lyase
total genus 257
structure length 653
sequence length 670
chains with identical sequence B
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2010-07-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 3nz4A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3nz4A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3nz4A02
1EB4A 2O7FA 1TJUA 1J3UA 1TJWA 1FUQA 2O7BA 2NYFA 1Y2MA 4EEIA 5F92A 3E04A 3GTDA 4NSLA 2RJRA 4FLCA 3GZHA 4ADMA 2FUSA 3NO9A 5D6BA 2PTQA 1HY1A 1Q5NA 4ADLA 1YFEA 4APAA 1KQ7A 2OHYA 1DCNA 3QBPA 3TV2A 2J91A 1TJVA 4C6GA 4C5UA 3R6QA 4NLEA 1GKMA 1TJ7A 2O6YA 1K7WA 3UNVA 4CQ5A 3R6YA 4BABA 2X75A 1C3UA 2HVGA 2O7EA 5EYVA 3BHGA 1HY0A 2O7DA 3CZOA 2PFMA 4V2QA 1VDKA 2O78A 4BAAA 1FUOA 3OCFA 4MX2A 1JSWA 2NYNA 1W27A 1YISA 1T6PA 4HGVA 3C8TA 2E9FA 3OCEA 4FFXA 1RE5A 4EFCA 1I0AA 3RRPA 1GK2A 5HW2A 4C5SA 1GKJA 2QVEA 2VD6A 1AUWA 1DOFA 1GK3A 2PTRA 5EYTA 2YIIA 3KDYA 1FURA 1U15A 1XWOA 1B8FA 2PTSA 4APBA 1T6JA 4V2RA 3KDZA 4C5RA 1YFMA 3NZ4A 1U16A 2QGAB 3R6VA 2RJSA 3RD8A 1C3CA 1K62A 1FUPA 5F91A
chains in the Genus database with same CATH superfamily
4A15A 1EB4A 1ZYRD 2JA5A 2VK9A 1XL7A 2O7FA 1TJUA 2MX9A 1J3UA 2X0PA 1TJWA 1FUQA 2O7BA 1I50A 2K3QA 3GTPA 2NYFA 1Y2MA 2K3OA 4EEIA 1XLYA 5F92A 3E04A 2JA6A 3GTDA 2EZBA 3EZBA 1SMYD 3CRW1 4NSLA 2RJRA 4FLCA 2FENA 2BE5D 3GZHA 4ADMA 2R92A 2FUSA 2R93A 2E2HA 3NO9A 1K83A 2CW0D 5D6BA 2FIPA 2PTQA 1HY1A 1Q5NA 1I3QA 2VSFA 2EZCA 5M0JA 4ADLA 1TWCA 1YFEA 3LR8A 3CRVA 4APAA 2FELA 1YNJD 1KQ7A 1SFOA 3LR6A 2F5JA 2OHYA 3LR2A 2A6ED 2JA7A 1DCNA 3QBPA 2YU9A 3TV2A 2J91A 1TJVA 1R9TA 1TWFA 4C6GA 2VL7A 1TWAA 4C5UA 4NLEA 3R6QA 1GKMA 1TJ7A 2O6YA 1K7WA 3UNVA 4CQ5A 2NVYA 1XMDA 3R6YA 1IW7D 2A68D 2HWGA 4BABA 3GTKA 4QIWA 1ZYMA 2X75A 2LTHA 1C3UA 2HVGA 2Y0NA 2A69D 2MP0A 2MQAA 3H0GA 1Y1VA 3U44A 2O7EA 3LRDA 5EYVA 3BHGA 3U4QA 1HY0A 2O7DA 3CZOA 2PFMA 4V2QA 2O5JD 1VDKA 2K3NA 2O78A 2X0OA 1YNND 4BAAA 1FUOA 3OCFA 3GTOA 3GTMA 1XL8A 1JSWA 4MX2A 2NYNA 1EZAA 1W27A 2VUMA 1YISA 5H8WA 4C2MA 1T6PA 4HGVA 3C8TA 1TWGA 2E9FA 3OCEA 1EZBA 2LPIA 4FFXA 1RE5A 4FBSA 4EFCA 1I0AA 2A6HD 4CEHA 1Y1WA 3RRPA 2AQLA 3FKIA 1I6VD 1GK2A 2MX8A 5HW2A 4C5SA 3GTQA 1XMCA 1GKJA 3GTGA 2QVEA 2VD6A 2LYIA 1AUWA 1DOFA 1GK3A 3GTJA 2PTRA 5EYTA 2N3EA 2FIOA 2LKMB 2YIIA 5IZ2A 1HQMD 4WNLA 5M0IA 3CQZA 1WCMA 2R7ZA 3KDYA 1FURA 3EZEA 4CEJA 1U15A 2X0QA 1XWOA 1B8FA 2PTSA 4APBA 1T6JA 4V2RA 3KDZA 2B63A 4C5RA 3GTLA 1YFMA 4CEIA 2EZAA 3NZ4A 1U16A 2QGAB 3R6VA 2LPJA 2HROA 2E2IA 2RJSA 3RD8A 1C3CA 2N1DB 1K62A 3EZAA 1TWHA 1FUPA 2NVXA 5F91A
chains in the Genus database with same CATH topology
1EB4A 2O7FA 1TJUA 1J3UA 1TJWA 1FUQA 2O7BA 2NYFA 1Y2MA 4EEIA 5F92A 3E04A 3GTDA 4NSLA 2RJRA 4FLCA 3GZHA 4ADMA 2FUSA 3NO9A 5D6BA 2PTQA 1HY1A 1Q5NA 4ADLA 1YFEA 4APAA 1KQ7A 2OHYA 1DCNA 3QBPA 3TV2A 2J91A 1TJVA 4C6GA 4C5UA 3R6QA 4NLEA 1GKMA 1TJ7A 2O6YA 1K7WA 3UNVA 4CQ5A 3R6YA 4BABA 2X75A 1C3UA 2HVGA 2O7EA 5EYVA 3BHGA 1HY0A 2O7DA 3CZOA 2PFMA 4V2QA 1VDKA 2O78A 4BAAA 1FUOA 3OCFA 4MX2A 1JSWA 2NYNA 1W27A 1YISA 1T6PA 4HGVA 3C8TA 2E9FA 3OCEA 4FFXA 1RE5A 4EFCA 1I0AA 3RRPA 1GK2A 5HW2A 4C5SA 1GKJA 2QVEA 2VD6A 1AUWA 1DOFA 1GK3A 2PTRA 5EYTA 2YIIA 3KDYA 1FURA 1U15A 1XWOA 1B8FA 2PTSA 4APBA 1T6JA 4V2RA 3KDZA 4C5RA 1YFMA 3NZ4A 1U16A 2QGAB 3R6VA 2RJSA 3RD8A 1C3CA 1K62A 1FUPA 5F91A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EB4 A;  2O7F A;  1TJU A;  1J3U A;  1TJW A;  1FUQ A;  2O7B A;  2NYF A;  1Y2M A;  4EEI A;  5F92 A;  3E04 A;  3GTD A;  4NSL A;  2RJR A;  4FLC A;  3GZH A;  4ADM A;  2FUS A;  3NO9 A;  5D6B A;  2PTQ A;  1HY1 A;  1Q5N A;  4ADL A;  1YFE A;  4APA A;  1KQ7 A;  2OHY A;  1DCN A;  3QBP A;  3TV2 A;  2J91 A;  1TJV A;  4C6G A;  4C5U A;  3R6Q A;  4NLE A;  1GKM A;  1TJ7 A;  2O6Y A;  1K7W A;  3UNV A;  4CQ5 A;  3R6Y A;  4BAB A;  2X75 A;  1C3U A;  2HVG A;  2O7E A;  5EYV A;  3BHG A;  1HY0 A;  2O7D A;  3CZO A;  2PFM A;  4V2Q A;  1VDK A;  2O78 A;  4BAA A;  1FUO A;  3OCF A;  4MX2 A;  1JSW A;  2NYN A;  1W27 A;  1YIS A;  1T6P A;  4HGV A;  3C8T A;  2E9F A;  3OCE A;  4FFX A;  1RE5 A;  4EFC A;  1I0A A;  3RRP A;  1GK2 A;  5HW2 A;  4C5S A;  1GKJ A;  2QVE A;  2VD6 A;  1AUW A;  1DOF A;  1GK3 A;  2PTR A;  5EYT A;  2YII A;  3KDY A;  1FUR A;  1U15 A;  1XWO A;  1B8F A;  2PTS A;  4APB A;  1T6J A;  4V2R A;  3KDZ A;  4C5R A;  1YFM A;  3NZ4 A;  1U16 A;  2QGA B;  3R6V A;  2RJS A;  3RD8 A;  1C3C A;  1K62 A;  1FUP A;  5F91 A; 
#chains in the Genus database with same CATH topology
 4A15 A;  1EB4 A;  1ZYR D;  2JA5 A;  2VK9 A;  1XL7 A;  2O7F A;  1TJU A;  2MX9 A;  1J3U A;  2X0P A;  1TJW A;  1FUQ A;  2O7B A;  1I50 A;  2K3Q A;  3GTP A;  2NYF A;  1Y2M A;  2K3O A;  4EEI A;  1XLY A;  5F92 A;  3E04 A;  2JA6 A;  3GTD A;  2EZB A;  3EZB A;  1SMY D;  3CRW 1;  4NSL A;  2RJR A;  4FLC A;  2FEN A;  2BE5 D;  3GZH A;  4ADM A;  2R92 A;  2FUS A;  2R93 A;  2E2H A;  3NO9 A;  1K83 A;  2CW0 D;  5D6B A;  2FIP A;  2PTQ A;  1HY1 A;  1Q5N A;  1I3Q A;  2VSF A;  2EZC A;  5M0J A;  4ADL A;  1TWC A;  1YFE A;  3LR8 A;  3CRV A;  4APA A;  2FEL A;  1YNJ D;  1KQ7 A;  1SFO A;  3LR6 A;  2F5J A;  2OHY A;  3LR2 A;  2A6E D;  2JA7 A;  1DCN A;  3QBP A;  2YU9 A;  3TV2 A;  2J91 A;  1TJV A;  1R9T A;  1TWF A;  4C6G A;  2VL7 A;  1TWA A;  4C5U A;  4NLE A;  3R6Q A;  1GKM A;  1TJ7 A;  2O6Y A;  1K7W A;  3UNV A;  4CQ5 A;  2NVY A;  1XMD A;  3R6Y A;  1IW7 D;  2A68 D;  2HWG A;  4BAB A;  3GTK A;  4QIW A;  1ZYM A;  2X75 A;  2LTH A;  1C3U A;  2HVG A;  2Y0N A;  2A69 D;  2MP0 A;  2MQA A;  3H0G A;  1Y1V A;  3U44 A;  2O7E A;  3LRD A;  5EYV A;  3BHG A;  3U4Q A;  1HY0 A;  2O7D A;  3CZO A;  2PFM A;  4V2Q A;  2O5J D;  1VDK A;  2K3N A;  2O78 A;  2X0O A;  1YNN D;  4BAA A;  1FUO A;  3OCF A;  3GTO A;  3GTM A;  1XL8 A;  1JSW A;  4MX2 A;  2NYN A;  1EZA A;  1W27 A;  2VUM A;  1YIS A;  5H8W A;  4C2M A;  1T6P A;  4HGV A;  3C8T A;  1TWG A;  2E9F A;  3OCE A;  1EZB A;  2LPI A;  4FFX A;  1RE5 A;  4FBS A;  4EFC A;  1I0A A;  2A6H D;  4CEH A;  1Y1W A;  3RRP A;  2AQL A;  3FKI A;  1I6V D;  1GK2 A;  2MX8 A;  5HW2 A;  4C5S A;  3GTQ A;  1XMC A;  1GKJ A;  3GTG A;  2QVE A;  2VD6 A;  2LYI A;  1AUW A;  1DOF A;  1GK3 A;  3GTJ A;  2PTR A;  5EYT A;  2N3E A;  2FIO A;  2LKM B;  2YII A;  5IZ2 A;  1HQM D;  4WNL A;  5M0I A;  3CQZ A;  1WCM A;  2R7Z A;  3KDY A;  1FUR A;  3EZE A;  4CEJ A;  1U15 A;  2X0Q A;  1XWO A;  1B8F A;  2PTS A;  4APB A;  1T6J A;  4V2R A;  3KDZ A;  2B63 A;  4C5R A;  3GTL A;  1YFM A;  4CEI A;  2EZA A;  3NZ4 A;  1U16 A;  2QGA B;  3R6V A;  2LPJ A;  2HRO A;  2E2I A;  2RJS A;  3RD8 A;  1C3C A;  2N1D B;  1K62 A;  3EZA A;  1TWH A;  1FUP A;  2NVX A;  5F91 A; 
#chains in the Genus database with same CATH homology
 1EB4 A;  2O7F A;  1TJU A;  1J3U A;  1TJW A;  1FUQ A;  2O7B A;  2NYF A;  1Y2M A;  4EEI A;  5F92 A;  3E04 A;  3GTD A;  4NSL A;  2RJR A;  4FLC A;  3GZH A;  4ADM A;  2FUS A;  3NO9 A;  5D6B A;  2PTQ A;  1HY1 A;  1Q5N A;  4ADL A;  1YFE A;  4APA A;  1KQ7 A;  2OHY A;  1DCN A;  3QBP A;  3TV2 A;  2J91 A;  1TJV A;  4C6G A;  4C5U A;  3R6Q A;  4NLE A;  1GKM A;  1TJ7 A;  2O6Y A;  1K7W A;  3UNV A;  4CQ5 A;  3R6Y A;  4BAB A;  2X75 A;  1C3U A;  2HVG A;  2O7E A;  5EYV A;  3BHG A;  1HY0 A;  2O7D A;  3CZO A;  2PFM A;  4V2Q A;  1VDK A;  2O78 A;  4BAA A;  1FUO A;  3OCF A;  4MX2 A;  1JSW A;  2NYN A;  1W27 A;  1YIS A;  1T6P A;  4HGV A;  3C8T A;  2E9F A;  3OCE A;  4FFX A;  1RE5 A;  4EFC A;  1I0A A;  3RRP A;  1GK2 A;  5HW2 A;  4C5S A;  1GKJ A;  2QVE A;  2VD6 A;  1AUW A;  1DOF A;  1GK3 A;  2PTR A;  5EYT A;  2YII A;  3KDY A;  1FUR A;  1U15 A;  1XWO A;  1B8F A;  2PTS A;  4APB A;  1T6J A;  4V2R A;  3KDZ A;  4C5R A;  1YFM A;  3NZ4 A;  1U16 A;  2QGA B;  3R6V A;  2RJS A;  3RD8 A;  1C3C A;  1K62 A;  1FUP A;  5F91 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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