3NZ4A

Crystal structure of a taxus phenylalanine aminomutase
Total Genus 257
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
257
sequence length
670
structure length
653
Chain Sequence
SRSHVKDILGLINTFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNQLSELQESLIRCLLAGVFTKGCASSVDELPATVTRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATALASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQDLSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTDEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFGSILALHKETDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSRFLPFYRFVRDELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFLG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Lyase
molecule keywords Phenylalanine ammonia-lyase
publication title Mechanistic, mutational, and structural evaluation of a taxus phenylalanine aminomutase.
pubmed doi rcsb
source organism Taxus canadensis
total genus 257
structure length 653
sequence length 670
chains with identical sequence B
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2010-07-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 3nz4A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3nz4A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3nz4A02
4ADMA 1T6PA 4BABA 4BAAA 1FUPA 1C3CA 1FUQA 1TJWA 2YIIA 4FLCA 3E04A 3RRPA 1B8FA 3UNVA 4EEIA 1Q5NA 4APAA 2VD6A 1GKJA 2PTSA 2O7EA 1GK3A 3NZ4A 1U15A 1GKMA 2NYNA 1AUWA 1J3UA 1YFEA 3R6YA 2FUSA 2E9FA 1VDKA 1HY1A 2HVGA 2PFMA 2RJSA 1XWOA 1EB4A 5EYVA 5F92A 4C5SA 2O7FA 4HGVA 2OHYA 1U16A 2RJRA 5F91A 2QVEA 3BHGA 4APBA 5D6BA 3TV2A 3GTDA 1T6JA 1I0AA 3QBPA 3KDZA 2QGAB 4C5RA 1YFMA 2O7DA 1TJUA 2O6YA 1FUOA 3RD8A 4CQ5A 1JSWA 1DOFA 1Y2MA 1KQ7A 1TJ7A 4ADLA 3NO9A 1YISA 1RE5A 3R6VA 4V2RA 4NSLA 2PTQA 4FFXA 1TJVA 3C8TA 2J91A 2NYFA 4NLEA 1K7WA 3R6QA 3OCFA 1W27A 4EFCA 5HW2A 4MX2A 2PTRA 1FURA 5EYTA 3KDYA 2X75A 3GZHA 4C6GA 2O78A 3OCEA 3CZOA 1HY0A 4C5UA 2O7BA 1GK2A 4V2QA 1C3UA 1DCNA 1K62A
chains in the Genus database with same CATH superfamily
1HQMD 2JA6A 3CRVA 5H8WA 4ADMA 1TWAA 1R9TA 1T6PA 2VK9A 3GTQA 2N3EA 4BABA 1XMDA 2R93A 4BAAA 1IW7D 1FUPA 2BE5D 1C3CA 1FUQA 1TJWA 2YIIA 3GTJA 4FLCA 3E04A 3RRPA 2A68D 2MX8A 1B8FA 3UNVA 1TWCA 4EEIA 2A69D 1Q5NA 4APAA 2LPIA 2VD6A 1GKJA 3U44A 4WNLA 2PTSA 3GTLA 1SMYD 1I6VD 1ZYMA 2FIOA 2O7EA 2K3QA 1YNJD 2EZAA 3LR2A 1GK3A 4QIWA 1Y1VA 3NZ4A 1U15A 1GKMA 2Y0NA 1EZAA 2NYNA 1AUWA 1J3UA 1K83A 1YFEA 3R6YA 2FUSA 2LPJA 2E9FA 1VDKA 1HY1A 1XWOA 2HVGA 2PFMA 2RJSA 5M0IA 1EB4A 5EYVA 3GTPA 2E2HA 2K3OA 3H0GA 2O5JD 4C5SA 1ZYRD 4FBSA 2O7FA 4HGVA 5F92A 2A6HD 1U16A 2OHYA 2FIPA 2RJRA 5F91A 2QVEA 3BHGA 2MX9A 4APBA 2F5JA 1TWHA 5D6BA 3TV2A 2X0OA 2FELA 2EZBA 3CQZA 1SFOA 2NVXA 3GTDA 4CEIA 1T6JA 2E2IA 1I0AA 2MQAA 3QBPA 3KDZA 2X0PA 2VUMA 2QGAB 4CEHA 4C5RA 2LYIA 3EZEA 1YFMA 2O7DA 2VL7A 3LR8A 1TJUA 1WCMA 2O6YA 1FUOA 3CRW1 3RD8A 1YNND 4CQ5A 1JSWA 1DOFA 1Y2MA 1KQ7A 1TJ7A 4CEJA 4ADLA 3NO9A 1YISA 1RE5A 3R6VA 1XLYA 4V2RA 4NSLA 2A6ED 1XL7A 1XMCA 2PTQA 4FFXA 2N1DB 1TJVA 3LRDA 3C8TA 1I50A 2JA7A 2CW0D 2J91A 2HWGA 1K62A 2NYFA 2B63A 4NLEA 2X0QA 1K7WA 2AQLA 2LTHA 3R6QA 4A15A 2NVYA 3LR6A 2R92A 2LKMB 2K3NA 2HROA 2JA5A 3EZBA 1I3QA 1XL8A 3OCFA 2MP0A 1W27A 5M0JA 4EFCA 5HW2A 4MX2A 2FENA 2PTRA 1FURA 5EYTA 3KDYA 1TWGA 3U4QA 2X75A 3FKIA 1TWFA 3GZHA 2EZCA 3EZAA 4C6GA 3GTKA 2O78A 3OCEA 1EZBA 2YU9A 3CZOA 1HY0A 2R7ZA 2VSFA 4C5UA 4C2MA 1GK2A 3GTGA 2O7BA 3GTMA 4V2QA 1C3UA 5IZ2A 1DCNA 3GTOA 1Y1WA
chains in the Genus database with same CATH topology
4ADMA 1T6PA 4BABA 4BAAA 1FUPA 1C3CA 1FUQA 1TJWA 2YIIA 4FLCA 3E04A 3RRPA 1B8FA 3UNVA 4EEIA 1Q5NA 4APAA 2VD6A 1GKJA 2PTSA 2O7EA 1GK3A 3NZ4A 1U15A 1GKMA 2NYNA 1AUWA 1J3UA 1YFEA 3R6YA 2FUSA 2E9FA 1VDKA 1HY1A 2HVGA 2PFMA 2RJSA 1XWOA 1EB4A 5EYVA 5F92A 4C5SA 2O7FA 4HGVA 2OHYA 1U16A 2RJRA 5F91A 2QVEA 3BHGA 4APBA 5D6BA 3TV2A 3GTDA 1T6JA 1I0AA 3QBPA 3KDZA 2QGAB 4C5RA 1YFMA 2O7DA 1TJUA 2O6YA 1FUOA 3RD8A 4CQ5A 1JSWA 1DOFA 1Y2MA 1KQ7A 1TJ7A 4ADLA 3NO9A 1YISA 1RE5A 3R6VA 4V2RA 4NSLA 2PTQA 4FFXA 1TJVA 3C8TA 2J91A 2NYFA 4NLEA 1K7WA 3R6QA 3OCFA 1W27A 4EFCA 5HW2A 4MX2A 2PTRA 1FURA 5EYTA 3KDYA 2X75A 3GZHA 4C6GA 2O78A 3OCEA 3CZOA 1HY0A 4C5UA 2O7BA 1GK2A 4V2QA 1C3UA 1DCNA 1K62A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ADM A;  1T6P A;  4BAB A;  4BAA A;  1FUP A;  1C3C A;  1FUQ A;  1TJW A;  2YII A;  4FLC A;  3E04 A;  3RRP A;  1B8F A;  3UNV A;  4EEI A;  1Q5N A;  4APA A;  2VD6 A;  1GKJ A;  2PTS A;  2O7E A;  1GK3 A;  3NZ4 A;  1U15 A;  1GKM A;  2NYN A;  1AUW A;  1J3U A;  1YFE A;  3R6Y A;  2FUS A;  2E9F A;  1VDK A;  1HY1 A;  2HVG A;  2PFM A;  2RJS A;  1XWO A;  1EB4 A;  5EYV A;  5F92 A;  4C5S A;  2O7F A;  4HGV A;  2OHY A;  1U16 A;  2RJR A;  5F91 A;  2QVE A;  3BHG A;  4APB A;  5D6B A;  3TV2 A;  3GTD A;  1T6J A;  1I0A A;  3QBP A;  3KDZ A;  2QGA B;  4C5R A;  1YFM A;  2O7D A;  1TJU A;  2O6Y A;  1FUO A;  3RD8 A;  4CQ5 A;  1JSW A;  1DOF A;  1Y2M A;  1KQ7 A;  1TJ7 A;  4ADL A;  3NO9 A;  1YIS A;  1RE5 A;  3R6V A;  4V2R A;  4NSL A;  2PTQ A;  4FFX A;  1TJV A;  3C8T A;  2J91 A;  2NYF A;  4NLE A;  1K7W A;  3R6Q A;  3OCF A;  1W27 A;  4EFC A;  5HW2 A;  4MX2 A;  2PTR A;  1FUR A;  5EYT A;  3KDY A;  2X75 A;  3GZH A;  4C6G A;  2O78 A;  3OCE A;  3CZO A;  1HY0 A;  4C5U A;  2O7B A;  1GK2 A;  4V2Q A;  1C3U A;  1DCN A;  1K62 A; 
#chains in the Genus database with same CATH topology
 1HQM D;  2JA6 A;  3CRV A;  5H8W A;  4ADM A;  1TWA A;  1R9T A;  1T6P A;  2VK9 A;  3GTQ A;  2N3E A;  4BAB A;  1XMD A;  2R93 A;  4BAA A;  1IW7 D;  1FUP A;  2BE5 D;  1C3C A;  1FUQ A;  1TJW A;  2YII A;  3GTJ A;  4FLC A;  3E04 A;  3RRP A;  2A68 D;  2MX8 A;  1B8F A;  3UNV A;  1TWC A;  4EEI A;  2A69 D;  1Q5N A;  4APA A;  2LPI A;  2VD6 A;  1GKJ A;  3U44 A;  4WNL A;  2PTS A;  3GTL A;  1SMY D;  1I6V D;  1ZYM A;  2FIO A;  2O7E A;  2K3Q A;  1YNJ D;  2EZA A;  3LR2 A;  1GK3 A;  4QIW A;  1Y1V A;  3NZ4 A;  1U15 A;  1GKM A;  2Y0N A;  1EZA A;  2NYN A;  1AUW A;  1J3U A;  1K83 A;  1YFE A;  3R6Y A;  2FUS A;  2LPJ A;  2E9F A;  1VDK A;  1HY1 A;  1XWO A;  2HVG A;  2PFM A;  2RJS A;  5M0I A;  1EB4 A;  5EYV A;  3GTP A;  2E2H A;  2K3O A;  3H0G A;  2O5J D;  4C5S A;  1ZYR D;  4FBS A;  2O7F A;  4HGV A;  5F92 A;  2A6H D;  1U16 A;  2OHY A;  2FIP A;  2RJR A;  5F91 A;  2QVE A;  3BHG A;  2MX9 A;  4APB A;  2F5J A;  1TWH A;  5D6B A;  3TV2 A;  2X0O A;  2FEL A;  2EZB A;  3CQZ A;  1SFO A;  2NVX A;  3GTD A;  4CEI A;  1T6J A;  2E2I A;  1I0A A;  2MQA A;  3QBP A;  3KDZ A;  2X0P A;  2VUM A;  2QGA B;  4CEH A;  4C5R A;  2LYI A;  3EZE A;  1YFM A;  2O7D A;  2VL7 A;  3LR8 A;  1TJU A;  1WCM A;  2O6Y A;  1FUO A;  3CRW 1;  3RD8 A;  1YNN D;  4CQ5 A;  1JSW A;  1DOF A;  1Y2M A;  1KQ7 A;  1TJ7 A;  4CEJ A;  4ADL A;  3NO9 A;  1YIS A;  1RE5 A;  3R6V A;  1XLY A;  4V2R A;  4NSL A;  2A6E D;  1XL7 A;  1XMC A;  2PTQ A;  4FFX A;  2N1D B;  1TJV A;  3LRD A;  3C8T A;  1I50 A;  2JA7 A;  2CW0 D;  2J91 A;  2HWG A;  1K62 A;  2NYF A;  2B63 A;  4NLE A;  2X0Q A;  1K7W A;  2AQL A;  2LTH A;  3R6Q A;  4A15 A;  2NVY A;  3LR6 A;  2R92 A;  2LKM B;  2K3N A;  2HRO A;  2JA5 A;  3EZB A;  1I3Q A;  1XL8 A;  3OCF A;  2MP0 A;  1W27 A;  5M0J A;  4EFC A;  5HW2 A;  4MX2 A;  2FEN A;  2PTR A;  1FUR A;  5EYT A;  3KDY A;  1TWG A;  3U4Q A;  2X75 A;  3FKI A;  1TWF A;  3GZH A;  2EZC A;  3EZA A;  4C6G A;  3GTK A;  2O78 A;  3OCE A;  1EZB A;  2YU9 A;  3CZO A;  1HY0 A;  2R7Z A;  2VSF A;  4C5U A;  4C2M A;  1GK2 A;  3GTG A;  2O7B A;  3GTM A;  4V2Q A;  1C3U A;  5IZ2 A;  1DCN A;  3GTO A;  1Y1W A; 
#chains in the Genus database with same CATH homology
 4ADM A;  1T6P A;  4BAB A;  4BAA A;  1FUP A;  1C3C A;  1FUQ A;  1TJW A;  2YII A;  4FLC A;  3E04 A;  3RRP A;  1B8F A;  3UNV A;  4EEI A;  1Q5N A;  4APA A;  2VD6 A;  1GKJ A;  2PTS A;  2O7E A;  1GK3 A;  3NZ4 A;  1U15 A;  1GKM A;  2NYN A;  1AUW A;  1J3U A;  1YFE A;  3R6Y A;  2FUS A;  2E9F A;  1VDK A;  1HY1 A;  2HVG A;  2PFM A;  2RJS A;  1XWO A;  1EB4 A;  5EYV A;  5F92 A;  4C5S A;  2O7F A;  4HGV A;  2OHY A;  1U16 A;  2RJR A;  5F91 A;  2QVE A;  3BHG A;  4APB A;  5D6B A;  3TV2 A;  3GTD A;  1T6J A;  1I0A A;  3QBP A;  3KDZ A;  2QGA B;  4C5R A;  1YFM A;  2O7D A;  1TJU A;  2O6Y A;  1FUO A;  3RD8 A;  4CQ5 A;  1JSW A;  1DOF A;  1Y2M A;  1KQ7 A;  1TJ7 A;  4ADL A;  3NO9 A;  1YIS A;  1RE5 A;  3R6V A;  4V2R A;  4NSL A;  2PTQ A;  4FFX A;  1TJV A;  3C8T A;  2J91 A;  2NYF A;  4NLE A;  1K7W A;  3R6Q A;  3OCF A;  1W27 A;  4EFC A;  5HW2 A;  4MX2 A;  2PTR A;  1FUR A;  5EYT A;  3KDY A;  2X75 A;  3GZH A;  4C6G A;  2O78 A;  3OCE A;  3CZO A;  1HY0 A;  4C5U A;  2O7B A;  1GK2 A;  4V2Q A;  1C3U A;  1DCN A;  1K62 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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