3NZ4A

Crystal structure of a taxus phenylalanine aminomutase
Total Genus 257
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
257
sequence length
670
structure length
653
Chain Sequence
SRSHVKDILGLINTFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNQLSELQESLIRCLLAGVFTKGCASSVDELPATVTRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATALASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQDLSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTDEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFGSILALHKETDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSRFLPFYRFVRDELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFLG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Mechanistic, mutational, and structural evaluation of a taxus phenylalanine aminomutase.
pubmed doi rcsb
source organism Taxus canadensis
molecule tags Lyase
molecule keywords Phenylalanine ammonia-lyase
total genus 257
structure length 653
sequence length 670
chains with identical sequence B
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2010-07-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 3nz4A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3nz4A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3nz4A02
3UNVA 5F91A 3GTDA 4CQ5A 1W27A 1JSWA 3C8TA 1VDKA 2OHYA 1YISA 3KDZA 4EEIA 3R6VA 3NO9A 3QBPA 2RJSA 1TJWA 5D6BA 4HGVA 1HY0A 5EYVA 1I0AA 1Y2MA 1GK3A 1U16A 3NZ4A 4ADMA 1KQ7A 3E04A 3TV2A 3OCEA 1DOFA 1C3UA 2O7BA 1YFEA 4V2QA 2O78A 2PTRA 2QVEA 2RJRA 2FUSA 2PTSA 2E9FA 1T6PA 4APAA 1RE5A 2QGAB 2NYFA 4MX2A 3OCFA 1TJ7A 5EYTA 5F92A 4C5SA 1YFMA 2PFMA 3CZOA 4ADLA 1TJVA 1U15A 2VD6A 1HY1A 3RD8A 1T6JA 1FUQA 4C5UA 2J91A 2O7EA 2PTQA 1K62A 1C3CA 1XWOA 4BAAA 1FUOA 2O6YA 1FUPA 4FLCA 2NYNA 3BHGA 1J3UA 1K7WA 4BABA 1EB4A 4C5RA 1FURA 1GK2A 4NLEA 1GKJA 3RRPA 1DCNA 3R6YA 1TJUA 4NSLA 3R6QA 4APBA 3KDYA 5HW2A 2HVGA 4C6GA 4EFCA 4V2RA 2O7FA 2O7DA 4FFXA 1Q5NA 2X75A 1GKMA 1B8FA 1AUWA 2YIIA 3GZHA
chains in the Genus database with same CATH superfamily
3UNVA 1R9TA 2VUMA 1TWGA 5F91A 3GTLA 3GTDA 4CQ5A 1I50A 1W27A 1JSWA 3C8TA 1VDKA 2OHYA 1EZAA 2A6HD 2MQAA 1YISA 1TWFA 3GTOA 1I6VD 1Y1WA 3KDZA 3LR2A 2EZAA 4EEIA 4A15A 2JA5A 1SFOA 1YNJD 2JA6A 2N1DB 3R6VA 4CEIA 2EZBA 1WCMA 3EZBA 3NO9A 2K3OA 1YNND 3GTPA 3QBPA 1TWAA 1TJWA 2RJSA 2LYIA 5D6BA 4HGVA 1HY0A 3CRW1 5EYVA 1I0AA 1Y2MA 1Y1VA 1GK3A 1U16A 5M0JA 3NZ4A 4ADMA 2E2HA 2LPJA 1KQ7A 3CQZA 2VK9A 3U4QA 3E04A 5M0IA 2LKMB 3TV2A 2HWGA 3OCEA 1DOFA 2X0OA 1C3UA 1ZYMA 2O7BA 1YFEA 1TWHA 4V2QA 2O78A 2PTRA 2QVEA 2RJRA 2FUSA 2PTSA 2A69D 1IW7D 2Y0NA 2B63A 3GTQA 2LTHA 2E9FA 5H8WA 1T6PA 4APAA 3GTMA 2R7ZA 1RE5A 1ZYRD 2QGAB 2NYFA 4MX2A 2VL7A 2A6ED 3LR6A 1TJ7A 2A68D 3OCFA 5EYTA 5F92A 4C5SA 1YFMA 2PFMA 3CZOA 4ADLA 1TJVA 2F5JA 2X0QA 2CW0D 1XMCA 3H0GA 1U15A 2VD6A 1HY1A 2O5JD 1I3QA 3RD8A 1T6JA 1FUQA 3FKIA 4C5UA 2J91A 2BE5D 2FELA 2O7EA 5IZ2A 2PTQA 2LPIA 2FENA 1XLYA 2E2IA 1C3CA 1K62A 4BAAA 1FUOA 1XWOA 1SMYD 2K3NA 2O6YA 1FUPA 3GTJA 2R92A 1XL7A 3GTGA 4FLCA 3EZEA 2NYNA 2VSFA 2HROA 1TWCA 3BHGA 1XMDA 2YU9A 2R93A 4FBSA 1K83A 4CEHA 1HQMD 3EZAA 4QIWA 2AQLA 3LR8A 3GTKA 4BABA 1J3UA 1EZBA 2EZCA 1K7WA 3CRVA 2FIOA 1EB4A 4C5RA 1FURA 1GK2A 2K3QA 4NLEA 1GKJA 2FIPA 3RRPA 4C2MA 2MX9A 1DCNA 3R6YA 1TJUA 1XL8A 4NSLA 3R6QA 4APBA 3KDYA 5HW2A 3LRDA 4CEJA 2MP0A 2HVGA 4C6GA 3U44A 4EFCA 2NVYA 2NVXA 2X0PA 4V2RA 2O7FA 2O7DA 4FFXA 1Q5NA 2X75A 1GKMA 1B8FA 2JA7A 2MX8A 1AUWA 2YIIA 4WNLA 2N3EA 3GZHA
chains in the Genus database with same CATH topology
3UNVA 5F91A 3GTDA 4CQ5A 1W27A 1JSWA 3C8TA 1VDKA 2OHYA 1YISA 3KDZA 4EEIA 3R6VA 3NO9A 3QBPA 2RJSA 1TJWA 5D6BA 4HGVA 1HY0A 5EYVA 1I0AA 1Y2MA 1GK3A 1U16A 3NZ4A 4ADMA 1KQ7A 3E04A 3TV2A 3OCEA 1DOFA 1C3UA 2O7BA 1YFEA 4V2QA 2O78A 2PTRA 2QVEA 2RJRA 2FUSA 2PTSA 2E9FA 1T6PA 4APAA 1RE5A 2QGAB 2NYFA 4MX2A 3OCFA 1TJ7A 5EYTA 5F92A 4C5SA 1YFMA 2PFMA 3CZOA 4ADLA 1TJVA 1U15A 2VD6A 1HY1A 3RD8A 1T6JA 1FUQA 4C5UA 2J91A 2O7EA 2PTQA 1K62A 1C3CA 1XWOA 4BAAA 1FUOA 2O6YA 1FUPA 4FLCA 2NYNA 3BHGA 1J3UA 1K7WA 4BABA 1EB4A 4C5RA 1FURA 1GK2A 4NLEA 1GKJA 3RRPA 1DCNA 3R6YA 1TJUA 4NSLA 3R6QA 4APBA 3KDYA 5HW2A 2HVGA 4C6GA 4EFCA 4V2RA 2O7FA 2O7DA 4FFXA 1Q5NA 2X75A 1GKMA 1B8FA 1AUWA 2YIIA 3GZHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3UNV A;  5F91 A;  3GTD A;  4CQ5 A;  1W27 A;  1JSW A;  3C8T A;  1VDK A;  2OHY A;  1YIS A;  3KDZ A;  4EEI A;  3R6V A;  3NO9 A;  3QBP A;  2RJS A;  1TJW A;  5D6B A;  4HGV A;  1HY0 A;  5EYV A;  1I0A A;  1Y2M A;  1GK3 A;  1U16 A;  3NZ4 A;  4ADM A;  1KQ7 A;  3E04 A;  3TV2 A;  3OCE A;  1DOF A;  1C3U A;  2O7B A;  1YFE A;  4V2Q A;  2O78 A;  2PTR A;  2QVE A;  2RJR A;  2FUS A;  2PTS A;  2E9F A;  1T6P A;  4APA A;  1RE5 A;  2QGA B;  2NYF A;  4MX2 A;  3OCF A;  1TJ7 A;  5EYT A;  5F92 A;  4C5S A;  1YFM A;  2PFM A;  3CZO A;  4ADL A;  1TJV A;  1U15 A;  2VD6 A;  1HY1 A;  3RD8 A;  1T6J A;  1FUQ A;  4C5U A;  2J91 A;  2O7E A;  2PTQ A;  1K62 A;  1C3C A;  1XWO A;  4BAA A;  1FUO A;  2O6Y A;  1FUP A;  4FLC A;  2NYN A;  3BHG A;  1J3U A;  1K7W A;  4BAB A;  1EB4 A;  4C5R A;  1FUR A;  1GK2 A;  4NLE A;  1GKJ A;  3RRP A;  1DCN A;  3R6Y A;  1TJU A;  4NSL A;  3R6Q A;  4APB A;  3KDY A;  5HW2 A;  2HVG A;  4C6G A;  4EFC A;  4V2R A;  2O7F A;  2O7D A;  4FFX A;  1Q5N A;  2X75 A;  1GKM A;  1B8F A;  1AUW A;  2YII A;  3GZH A; 
#chains in the Genus database with same CATH topology
 3UNV A;  1R9T A;  2VUM A;  1TWG A;  5F91 A;  3GTL A;  3GTD A;  4CQ5 A;  1I50 A;  1W27 A;  1JSW A;  3C8T A;  1VDK A;  2OHY A;  1EZA A;  2A6H D;  2MQA A;  1YIS A;  1TWF A;  3GTO A;  1I6V D;  1Y1W A;  3KDZ A;  3LR2 A;  2EZA A;  4EEI A;  4A15 A;  2JA5 A;  1SFO A;  1YNJ D;  2JA6 A;  2N1D B;  3R6V A;  4CEI A;  2EZB A;  1WCM A;  3EZB A;  3NO9 A;  2K3O A;  1YNN D;  3GTP A;  3QBP A;  1TWA A;  1TJW A;  2RJS A;  2LYI A;  5D6B A;  4HGV A;  1HY0 A;  3CRW 1;  5EYV A;  1I0A A;  1Y2M A;  1Y1V A;  1GK3 A;  1U16 A;  5M0J A;  3NZ4 A;  4ADM A;  2E2H A;  2LPJ A;  1KQ7 A;  3CQZ A;  2VK9 A;  3U4Q A;  3E04 A;  5M0I A;  2LKM B;  3TV2 A;  2HWG A;  3OCE A;  1DOF A;  2X0O A;  1C3U A;  1ZYM A;  2O7B A;  1YFE A;  1TWH A;  4V2Q A;  2O78 A;  2PTR A;  2QVE A;  2RJR A;  2FUS A;  2PTS A;  2A69 D;  1IW7 D;  2Y0N A;  2B63 A;  3GTQ A;  2LTH A;  2E9F A;  5H8W A;  1T6P A;  4APA A;  3GTM A;  2R7Z A;  1RE5 A;  1ZYR D;  2QGA B;  2NYF A;  4MX2 A;  2VL7 A;  2A6E D;  3LR6 A;  1TJ7 A;  2A68 D;  3OCF A;  5EYT A;  5F92 A;  4C5S A;  1YFM A;  2PFM A;  3CZO A;  4ADL A;  1TJV A;  2F5J A;  2X0Q A;  2CW0 D;  1XMC A;  3H0G A;  1U15 A;  2VD6 A;  1HY1 A;  2O5J D;  1I3Q A;  3RD8 A;  1T6J A;  1FUQ A;  3FKI A;  4C5U A;  2J91 A;  2BE5 D;  2FEL A;  2O7E A;  5IZ2 A;  2PTQ A;  2LPI A;  2FEN A;  1XLY A;  2E2I A;  1C3C A;  1K62 A;  4BAA A;  1FUO A;  1XWO A;  1SMY D;  2K3N A;  2O6Y A;  1FUP A;  3GTJ A;  2R92 A;  1XL7 A;  3GTG A;  4FLC A;  3EZE A;  2NYN A;  2VSF A;  2HRO A;  1TWC A;  3BHG A;  1XMD A;  2YU9 A;  2R93 A;  4FBS A;  1K83 A;  4CEH A;  1HQM D;  3EZA A;  4QIW A;  2AQL A;  3LR8 A;  3GTK A;  4BAB A;  1J3U A;  1EZB A;  2EZC A;  1K7W A;  3CRV A;  2FIO A;  1EB4 A;  4C5R A;  1FUR A;  1GK2 A;  2K3Q A;  4NLE A;  1GKJ A;  2FIP A;  3RRP A;  4C2M A;  2MX9 A;  1DCN A;  3R6Y A;  1TJU A;  1XL8 A;  4NSL A;  3R6Q A;  4APB A;  3KDY A;  5HW2 A;  3LRD A;  4CEJ A;  2MP0 A;  2HVG A;  4C6G A;  3U44 A;  4EFC A;  2NVY A;  2NVX A;  2X0P A;  4V2R A;  2O7F A;  2O7D A;  4FFX A;  1Q5N A;  2X75 A;  1GKM A;  1B8F A;  2JA7 A;  2MX8 A;  1AUW A;  2YII A;  4WNL A;  2N3E A;  3GZH A; 
#chains in the Genus database with same CATH homology
 3UNV A;  5F91 A;  3GTD A;  4CQ5 A;  1W27 A;  1JSW A;  3C8T A;  1VDK A;  2OHY A;  1YIS A;  3KDZ A;  4EEI A;  3R6V A;  3NO9 A;  3QBP A;  2RJS A;  1TJW A;  5D6B A;  4HGV A;  1HY0 A;  5EYV A;  1I0A A;  1Y2M A;  1GK3 A;  1U16 A;  3NZ4 A;  4ADM A;  1KQ7 A;  3E04 A;  3TV2 A;  3OCE A;  1DOF A;  1C3U A;  2O7B A;  1YFE A;  4V2Q A;  2O78 A;  2PTR A;  2QVE A;  2RJR A;  2FUS A;  2PTS A;  2E9F A;  1T6P A;  4APA A;  1RE5 A;  2QGA B;  2NYF A;  4MX2 A;  3OCF A;  1TJ7 A;  5EYT A;  5F92 A;  4C5S A;  1YFM A;  2PFM A;  3CZO A;  4ADL A;  1TJV A;  1U15 A;  2VD6 A;  1HY1 A;  3RD8 A;  1T6J A;  1FUQ A;  4C5U A;  2J91 A;  2O7E A;  2PTQ A;  1K62 A;  1C3C A;  1XWO A;  4BAA A;  1FUO A;  2O6Y A;  1FUP A;  4FLC A;  2NYN A;  3BHG A;  1J3U A;  1K7W A;  4BAB A;  1EB4 A;  4C5R A;  1FUR A;  1GK2 A;  4NLE A;  1GKJ A;  3RRP A;  1DCN A;  3R6Y A;  1TJU A;  4NSL A;  3R6Q A;  4APB A;  3KDY A;  5HW2 A;  2HVG A;  4C6G A;  4EFC A;  4V2R A;  2O7F A;  2O7D A;  4FFX A;  1Q5N A;  2X75 A;  1GKM A;  1B8F A;  1AUW A;  2YII A;  3GZH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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