3NZ4A

Crystal structure of a taxus phenylalanine aminomutase
Total Genus 257
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
257
sequence length
670
structure length
653
Chain Sequence
SRSHVKDILGLINTFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNQLSELQESLIRCLLAGVFTKGCASSVDELPATVTRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATALASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQDLSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTDEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFGSILALHKETDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSRFLPFYRFVRDELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFLG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Mechanistic, mutational, and structural evaluation of a taxus phenylalanine aminomutase.
pubmed doi rcsb
molecule tags Lyase
source organism Taxus canadensis
molecule keywords Phenylalanine ammonia-lyase
total genus 257
structure length 653
sequence length 670
chains with identical sequence B
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2010-07-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 3nz4A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3nz4A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3nz4A02
1YISA 2X75A 1YFMA 4EFCA 1B8FA 1Y2MA 1U15A 2RJSA 3TV2A 3OCFA 3GZHA 1GK3A 5HW2A 4HGVA 3C8TA 3UNVA 2J91A 1I0AA 4V2QA 1FUQA 2PTSA 4BABA 1HY0A 1K7WA 2PTQA 2PTRA 1HY1A 1C3UA 1DCNA 4C5UA 5EYVA 4V2RA 1YFEA 3BHGA 1TJWA 1TJVA 4EEIA 1GKMA 1T6PA 3R6QA 3RRPA 1GKJA 4ADMA 2OHYA 3R6VA 3NZ4A 4BAAA 3RD8A 1RE5A 5F91A 1JSWA 5F92A 3R6YA 1XWOA 1EB4A 3QBPA 1FUPA 4C5SA 1AUWA 1C3CA 3OCEA 3E04A 1J3UA 1DOFA 2E9FA 2O6YA 3CZOA 4C6GA 1T6JA 4MX2A 2YIIA 1TJUA 2HVGA 2QVEA 1FUOA 2O7FA 3GTDA 4APAA 1TJ7A 4ADLA 4C5RA 4FFXA 5D6BA 1Q5NA 1VDKA 1KQ7A 2VD6A 3KDYA 1GK2A 2NYFA 4NSLA 2FUSA 4APBA 2O7BA 2NYNA 2O7EA 5EYTA 4CQ5A 1FURA 3KDZA 2QGAB 3NO9A 1K62A 2PFMA 1W27A 2O7DA 2O78A 4NLEA 2RJRA 4FLCA 1U16A
chains in the Genus database with same CATH superfamily
1YISA 2X75A 1YFMA 4EFCA 2NVXA 1B8FA 1Y2MA 1U15A 2RJSA 3GTPA 2LPJA 2VSFA 1U16A 3LR2A 3TV2A 3FKIA 2MP0A 3OCFA 3GZHA 1GK3A 5HW2A 1XL7A 4HGVA 2EZCA 1TWHA 3C8TA 2FIPA 4CEJA 2EZAA 2LTHA 3UNVA 1XL8A 2J91A 1I0AA 4QIWA 1I50A 4V2QA 1YNJD 1FUQA 3EZAA 2CW0D 2PTSA 2MQAA 3LR8A 4BABA 1HY0A 1K7WA 2HROA 2PTQA 2PTRA 2A6HD 1SFOA 1EZAA 3LRDA 1HY1A 2K3QA 1C3UA 4FLCA 1DCNA 4C5UA 5EYVA 2FELA 4V2RA 2K3OA 1YFEA 3BHGA 2R7ZA 2JA7A 3GTKA 1TJWA 5H8WA 1YNND 1TJVA 2K3NA 1XMDA 2VK9A 2A6ED 4EEIA 4WNLA 1GKMA 1T6PA 3R6QA 3RRPA 2N1DB 1IW7D 3GTLA 1GKJA 2MX8A 1TWAA 4ADMA 2NVYA 5M0JA 2OHYA 2FIOA 4CEIA 3R6VA 3NZ4A 4BAAA 3RD8A 1RE5A 5F91A 2HWGA 2VUMA 1JSWA 3GTMA 5F92A 2X0PA 3R6YA 4A15A 3GTOA 5IZ2A 1XLYA 1XWOA 2X0OA 1EB4A 3QBPA 1WCMA 1Y1VA 2YU9A 1FUPA 1ZYMA 4C5SA 2R93A 1AUWA 1EZBA 3GTGA 1C3CA 3OCEA 2AQLA 1TWGA 3E04A 1J3UA 2X0QA 1DOFA 2E9FA 2O6YA 3CZOA 2O5JD 4C6GA 5M0IA 2LPIA 2B63A 1T6JA 2VL7A 3EZBA 2E2IA 4MX2A 2YIIA 1TJUA 2HVGA 2QVEA 2E2HA 1FUOA 2A68D 2O7FA 3LR6A 3GTDA 3CRVA 4APAA 3CRW1 1TJ7A 2N3EA 2A69D 3GTJA 4ADLA 1SMYD 4C5RA 4FFXA 1R9TA 5D6BA 1Q5NA 4C2MA 1KQ7A 1VDKA 2VD6A 1I3QA 3KDYA 2LYIA 1GK2A 1I6VD 3U4QA 2JA6A 2NYFA 1ZYRD 2EZBA 1XMCA 2FUSA 1Y1WA 4NSLA 4APBA 2O7BA 2NYNA 2BE5D 2O7EA 3CQZA 2F5JA 3U44A 5EYTA 2JA5A 4CQ5A 1FURA 3H0GA 2Y0NA 2R92A 1HQMD 3EZEA 2LKMB 2QGAB 3GTQA 3KDZA 4FBSA 3NO9A 1K62A 1K83A 2PFMA 2FENA 2MX9A 1W27A 2O7DA 2O78A 4NLEA 2RJRA 1TWCA 1TWFA 4CEHA
chains in the Genus database with same CATH topology
1YISA 2X75A 1YFMA 4EFCA 1B8FA 1Y2MA 1U15A 2RJSA 3TV2A 3OCFA 3GZHA 1GK3A 5HW2A 4HGVA 3C8TA 3UNVA 2J91A 1I0AA 4V2QA 1FUQA 2PTSA 4BABA 1HY0A 1K7WA 2PTQA 2PTRA 1HY1A 1C3UA 1DCNA 4C5UA 5EYVA 4V2RA 1YFEA 3BHGA 1TJWA 1TJVA 4EEIA 1GKMA 1T6PA 3R6QA 3RRPA 1GKJA 4ADMA 2OHYA 3R6VA 3NZ4A 4BAAA 3RD8A 1RE5A 5F91A 1JSWA 5F92A 3R6YA 1XWOA 1EB4A 3QBPA 1FUPA 4C5SA 1AUWA 1C3CA 3OCEA 3E04A 1J3UA 1DOFA 2E9FA 2O6YA 3CZOA 4C6GA 1T6JA 4MX2A 2YIIA 1TJUA 2HVGA 2QVEA 1FUOA 2O7FA 3GTDA 4APAA 1TJ7A 4ADLA 4C5RA 4FFXA 5D6BA 1Q5NA 1VDKA 1KQ7A 2VD6A 3KDYA 1GK2A 2NYFA 4NSLA 2FUSA 4APBA 2O7BA 2NYNA 2O7EA 5EYTA 4CQ5A 1FURA 3KDZA 2QGAB 3NO9A 1K62A 2PFMA 1W27A 2O7DA 2O78A 4NLEA 2RJRA 4FLCA 1U16A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YIS A;  2X75 A;  1YFM A;  4EFC A;  1B8F A;  1Y2M A;  1U15 A;  2RJS A;  3TV2 A;  3OCF A;  3GZH A;  1GK3 A;  5HW2 A;  4HGV A;  3C8T A;  3UNV A;  2J91 A;  1I0A A;  4V2Q A;  1FUQ A;  2PTS A;  4BAB A;  1HY0 A;  1K7W A;  2PTQ A;  2PTR A;  1HY1 A;  1C3U A;  1DCN A;  4C5U A;  5EYV A;  4V2R A;  1YFE A;  3BHG A;  1TJW A;  1TJV A;  4EEI A;  1GKM A;  1T6P A;  3R6Q A;  3RRP A;  1GKJ A;  4ADM A;  2OHY A;  3R6V A;  3NZ4 A;  4BAA A;  3RD8 A;  1RE5 A;  5F91 A;  1JSW A;  5F92 A;  3R6Y A;  1XWO A;  1EB4 A;  3QBP A;  1FUP A;  4C5S A;  1AUW A;  1C3C A;  3OCE A;  3E04 A;  1J3U A;  1DOF A;  2E9F A;  2O6Y A;  3CZO A;  4C6G A;  1T6J A;  4MX2 A;  2YII A;  1TJU A;  2HVG A;  2QVE A;  1FUO A;  2O7F A;  3GTD A;  4APA A;  1TJ7 A;  4ADL A;  4C5R A;  4FFX A;  5D6B A;  1Q5N A;  1VDK A;  1KQ7 A;  2VD6 A;  3KDY A;  1GK2 A;  2NYF A;  4NSL A;  2FUS A;  4APB A;  2O7B A;  2NYN A;  2O7E A;  5EYT A;  4CQ5 A;  1FUR A;  3KDZ A;  2QGA B;  3NO9 A;  1K62 A;  2PFM A;  1W27 A;  2O7D A;  2O78 A;  4NLE A;  2RJR A;  4FLC A;  1U16 A; 
#chains in the Genus database with same CATH topology
 1YIS A;  2X75 A;  1YFM A;  4EFC A;  2NVX A;  1B8F A;  1Y2M A;  1U15 A;  2RJS A;  3GTP A;  2LPJ A;  2VSF A;  1U16 A;  3LR2 A;  3TV2 A;  3FKI A;  2MP0 A;  3OCF A;  3GZH A;  1GK3 A;  5HW2 A;  1XL7 A;  4HGV A;  2EZC A;  1TWH A;  3C8T A;  2FIP A;  4CEJ A;  2EZA A;  2LTH A;  3UNV A;  1XL8 A;  2J91 A;  1I0A A;  4QIW A;  1I50 A;  4V2Q A;  1YNJ D;  1FUQ A;  3EZA A;  2CW0 D;  2PTS A;  2MQA A;  3LR8 A;  4BAB A;  1HY0 A;  1K7W A;  2HRO A;  2PTQ A;  2PTR A;  2A6H D;  1SFO A;  1EZA A;  3LRD A;  1HY1 A;  2K3Q A;  1C3U A;  4FLC A;  1DCN A;  4C5U A;  5EYV A;  2FEL A;  4V2R A;  2K3O A;  1YFE A;  3BHG A;  2R7Z A;  2JA7 A;  3GTK A;  1TJW A;  5H8W A;  1YNN D;  1TJV A;  2K3N A;  1XMD A;  2VK9 A;  2A6E D;  4EEI A;  4WNL A;  1GKM A;  1T6P A;  3R6Q A;  3RRP A;  2N1D B;  1IW7 D;  3GTL A;  1GKJ A;  2MX8 A;  1TWA A;  4ADM A;  2NVY A;  5M0J A;  2OHY A;  2FIO A;  4CEI A;  3R6V A;  3NZ4 A;  4BAA A;  3RD8 A;  1RE5 A;  5F91 A;  2HWG A;  2VUM A;  1JSW A;  3GTM A;  5F92 A;  2X0P A;  3R6Y A;  4A15 A;  3GTO A;  5IZ2 A;  1XLY A;  1XWO A;  2X0O A;  1EB4 A;  3QBP A;  1WCM A;  1Y1V A;  2YU9 A;  1FUP A;  1ZYM A;  4C5S A;  2R93 A;  1AUW A;  1EZB A;  3GTG A;  1C3C A;  3OCE A;  2AQL A;  1TWG A;  3E04 A;  1J3U A;  2X0Q A;  1DOF A;  2E9F A;  2O6Y A;  3CZO A;  2O5J D;  4C6G A;  5M0I A;  2LPI A;  2B63 A;  1T6J A;  2VL7 A;  3EZB A;  2E2I A;  4MX2 A;  2YII A;  1TJU A;  2HVG A;  2QVE A;  2E2H A;  1FUO A;  2A68 D;  2O7F A;  3LR6 A;  3GTD A;  3CRV A;  4APA A;  3CRW 1;  1TJ7 A;  2N3E A;  2A69 D;  3GTJ A;  4ADL A;  1SMY D;  4C5R A;  4FFX A;  1R9T A;  5D6B A;  1Q5N A;  4C2M A;  1KQ7 A;  1VDK A;  2VD6 A;  1I3Q A;  3KDY A;  2LYI A;  1GK2 A;  1I6V D;  3U4Q A;  2JA6 A;  2NYF A;  1ZYR D;  2EZB A;  1XMC A;  2FUS A;  1Y1W A;  4NSL A;  4APB A;  2O7B A;  2NYN A;  2BE5 D;  2O7E A;  3CQZ A;  2F5J A;  3U44 A;  5EYT A;  2JA5 A;  4CQ5 A;  1FUR A;  3H0G A;  2Y0N A;  2R92 A;  1HQM D;  3EZE A;  2LKM B;  2QGA B;  3GTQ A;  3KDZ A;  4FBS A;  3NO9 A;  1K62 A;  1K83 A;  2PFM A;  2FEN A;  2MX9 A;  1W27 A;  2O7D A;  2O78 A;  4NLE A;  2RJR A;  1TWC A;  1TWF A;  4CEH A; 
#chains in the Genus database with same CATH homology
 1YIS A;  2X75 A;  1YFM A;  4EFC A;  1B8F A;  1Y2M A;  1U15 A;  2RJS A;  3TV2 A;  3OCF A;  3GZH A;  1GK3 A;  5HW2 A;  4HGV A;  3C8T A;  3UNV A;  2J91 A;  1I0A A;  4V2Q A;  1FUQ A;  2PTS A;  4BAB A;  1HY0 A;  1K7W A;  2PTQ A;  2PTR A;  1HY1 A;  1C3U A;  1DCN A;  4C5U A;  5EYV A;  4V2R A;  1YFE A;  3BHG A;  1TJW A;  1TJV A;  4EEI A;  1GKM A;  1T6P A;  3R6Q A;  3RRP A;  1GKJ A;  4ADM A;  2OHY A;  3R6V A;  3NZ4 A;  4BAA A;  3RD8 A;  1RE5 A;  5F91 A;  1JSW A;  5F92 A;  3R6Y A;  1XWO A;  1EB4 A;  3QBP A;  1FUP A;  4C5S A;  1AUW A;  1C3C A;  3OCE A;  3E04 A;  1J3U A;  1DOF A;  2E9F A;  2O6Y A;  3CZO A;  4C6G A;  1T6J A;  4MX2 A;  2YII A;  1TJU A;  2HVG A;  2QVE A;  1FUO A;  2O7F A;  3GTD A;  4APA A;  1TJ7 A;  4ADL A;  4C5R A;  4FFX A;  5D6B A;  1Q5N A;  1VDK A;  1KQ7 A;  2VD6 A;  3KDY A;  1GK2 A;  2NYF A;  4NSL A;  2FUS A;  4APB A;  2O7B A;  2NYN A;  2O7E A;  5EYT A;  4CQ5 A;  1FUR A;  3KDZ A;  2QGA B;  3NO9 A;  1K62 A;  2PFM A;  1W27 A;  2O7D A;  2O78 A;  4NLE A;  2RJR A;  4FLC A;  1U16 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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