4V2QA

Ironing out their differences: dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase
Total Genus 249
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
249
sequence length
666
structure length
612
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDELQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHETDTLVDRLAEFEKRLSDRLENEMTAVRVLYEVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGF
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Ironing Out Their Differences: Dissecting the Structural Determinants of a Phenylalanine Aminomutase and Ammonia Lyase.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE
total genus 249
structure length 612
sequence length 666
chains with identical sequence B
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2014-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4v2qA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4v2qA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4v2qA02
3RRPA 1FURA 3GZHA 2PFMA 2O7BA 2FUSA 1RE5A 4ADLA 1I0AA 3UNVA 2PTQA 3R6YA 4EFCA 1T6JA 4EEIA 1J3UA 4APBA 3QBPA 4HGVA 3R6QA 1GKJA 2HVGA 2O7FA 5EYVA 1VDKA 4FFXA 1Y2MA 1Q5NA 3RD8A 3OCFA 4FLCA 3OCEA 1DCNA 4V2QA 4C5UA 2VD6A 2RJSA 1TJWA 3C8TA 3E04A 1B8FA 2NYNA 3KDYA 4NLEA 1XWOA 2O78A 3R6VA 1DOFA 4ADMA 1C3UA 1AUWA 1W27A 1HY1A 2OHYA 1FUPA 1K62A 2X75A 1FUOA 2J91A 4C5SA 1YFMA 5D6BA 4MX2A 5HW2A 2NYFA 1FUQA 1TJ7A 1T6PA 2PTRA 3BHGA 1EB4A 1U16A 1GK2A 1GKMA 1U15A 1TJVA 2RJRA 5F92A 3GTDA 2PTSA 2QGAB 3NZ4A 4BAAA 5F91A 2E9FA 2QVEA 3KDZA 1JSWA 4V2RA 1YFEA 4CQ5A 4APAA 1C3CA 4BABA 3CZOA 1K7WA 2O7EA 1TJUA 3TV2A 4C6GA 1GK3A 5EYTA 1KQ7A 3NO9A 2YIIA 2O6YA 1YISA 4C5RA 4NSLA 2O7DA 1HY0A
chains in the Genus database with same CATH superfamily
2LKMB 3U44A 3RRPA 1FURA 2BE5D 3GZHA 1XMDA 5H8WA 2PFMA 3H0GA 3EZEA 4QIWA 2O7BA 2FUSA 2CW0D 3CQZA 1SFOA 5M0IA 3GTQA 2A6HD 1RE5A 1IW7D 4ADLA 1K83A 1I0AA 3UNVA 4CEHA 1XL8A 2PTQA 2JA6A 3R6YA 4EFCA 2FELA 1T6JA 1I3QA 2YU9A 4EEIA 1I6VD 1J3UA 2R93A 4APBA 3QBPA 2MX9A 4HGVA 1Y1VA 4FBSA 3R6QA 1GKJA 2HVGA 2F5JA 2O7FA 5EYVA 1VDKA 1TWFA 1WCMA 4C2MA 4FFXA 1Y2MA 1TWCA 1Q5NA 3OCFA 4FLCA 3OCEA 3RD8A 4V2QA 2LYIA 1DCNA 2JA5A 4C5UA 2VD6A 3GTMA 1XMCA 2RJSA 2X0OA 3LR6A 1TJWA 3C8TA 1Y1WA 2VSFA 1R9TA 3E04A 2O5JD 1YNJD 2VK9A 3CRW1 2EZAA 3EZBA 1B8FA 1YNND 2NYNA 3FKIA 3KDYA 3EZAA 2VUMA 4NLEA 1XWOA 2R7ZA 2E2IA 2O78A 3R6VA 3GTKA 5IZ2A 1DOFA 2JA7A 4ADMA 4A15A 1HQMD 1C3UA 1AUWA 1EZBA 2X0QA 1W27A 1HY1A 2OHYA 2NVYA 1FUPA 3CRVA 1K62A 2X75A 2Y0NA 1FUOA 2J91A 1TWAA 2A69D 2B63A 1I50A 4C5SA 1YFMA 2A6ED 3GTOA 5D6BA 4MX2A 5HW2A 2FIOA 2LPIA 2MX8A 2NYFA 3GTPA 1FUQA 1TJ7A 1T6PA 2PTRA 2FENA 3BHGA 2VL7A 2HROA 1TWHA 2X0PA 1EB4A 1GK2A 1U16A 1GKMA 1U15A 2MP0A 1TJVA 2K3OA 2RJRA 5F92A 3GTDA 2PTSA 2QGAB 2EZCA 2EZBA 3NZ4A 4BAAA 2K3QA 5F91A 3GTJA 2HWGA 2E9FA 2FIPA 2QVEA 1JSWA 3KDZA 1XLYA 4V2RA 3GTLA 4CEJA 1SMYD 2N1DB 2MQAA 2R92A 2E2HA 1YFEA 4CQ5A 1ZYMA 2N3EA 4APAA 1C3CA 4WNLA 4BABA 3CZOA 1K7WA 1XL7A 2O7EA 1TJUA 2K3NA 3U4QA 3LRDA 4CEIA 3LR2A 4C6GA 3TV2A 1GK3A 5EYTA 1EZAA 1KQ7A 2LTHA 3NO9A 1TWGA 2A68D 2LPJA 1ZYRD 2YIIA 3GTGA 2O6YA 1YISA 2AQLA 4C5RA 5M0JA 3LR8A 2NVXA 4NSLA 2O7DA 1HY0A
chains in the Genus database with same CATH topology
3RRPA 1FURA 3GZHA 2PFMA 2O7BA 2FUSA 1RE5A 4ADLA 1I0AA 3UNVA 2PTQA 3R6YA 4EFCA 1T6JA 4EEIA 1J3UA 4APBA 3QBPA 4HGVA 3R6QA 1GKJA 2HVGA 2O7FA 5EYVA 1VDKA 4FFXA 1Y2MA 1Q5NA 3RD8A 3OCFA 4FLCA 3OCEA 1DCNA 4V2QA 4C5UA 2VD6A 2RJSA 1TJWA 3C8TA 3E04A 1B8FA 2NYNA 3KDYA 4NLEA 1XWOA 2O78A 3R6VA 1DOFA 4ADMA 1C3UA 1AUWA 1W27A 1HY1A 2OHYA 1FUPA 1K62A 2X75A 1FUOA 2J91A 4C5SA 1YFMA 5D6BA 4MX2A 5HW2A 2NYFA 1FUQA 1TJ7A 1T6PA 2PTRA 3BHGA 1EB4A 1U16A 1GK2A 1GKMA 1U15A 1TJVA 2RJRA 5F92A 3GTDA 2PTSA 2QGAB 3NZ4A 4BAAA 5F91A 2E9FA 2QVEA 3KDZA 1JSWA 4V2RA 1YFEA 4CQ5A 4APAA 1C3CA 4BABA 3CZOA 1K7WA 2O7EA 1TJUA 3TV2A 4C6GA 1GK3A 5EYTA 1KQ7A 3NO9A 2YIIA 2O6YA 1YISA 4C5RA 4NSLA 2O7DA 1HY0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3RRP A;  1FUR A;  3GZH A;  2PFM A;  2O7B A;  2FUS A;  1RE5 A;  4ADL A;  1I0A A;  3UNV A;  2PTQ A;  3R6Y A;  4EFC A;  1T6J A;  4EEI A;  1J3U A;  4APB A;  3QBP A;  4HGV A;  3R6Q A;  1GKJ A;  2HVG A;  2O7F A;  5EYV A;  1VDK A;  4FFX A;  1Y2M A;  1Q5N A;  3RD8 A;  3OCF A;  4FLC A;  3OCE A;  1DCN A;  4V2Q A;  4C5U A;  2VD6 A;  2RJS A;  1TJW A;  3C8T A;  3E04 A;  1B8F A;  2NYN A;  3KDY A;  4NLE A;  1XWO A;  2O78 A;  3R6V A;  1DOF A;  4ADM A;  1C3U A;  1AUW A;  1W27 A;  1HY1 A;  2OHY A;  1FUP A;  1K62 A;  2X75 A;  1FUO A;  2J91 A;  4C5S A;  1YFM A;  5D6B A;  4MX2 A;  5HW2 A;  2NYF A;  1FUQ A;  1TJ7 A;  1T6P A;  2PTR A;  3BHG A;  1EB4 A;  1U16 A;  1GK2 A;  1GKM A;  1U15 A;  1TJV A;  2RJR A;  5F92 A;  3GTD A;  2PTS A;  2QGA B;  3NZ4 A;  4BAA A;  5F91 A;  2E9F A;  2QVE A;  3KDZ A;  1JSW A;  4V2R A;  1YFE A;  4CQ5 A;  4APA A;  1C3C A;  4BAB A;  3CZO A;  1K7W A;  2O7E A;  1TJU A;  3TV2 A;  4C6G A;  1GK3 A;  5EYT A;  1KQ7 A;  3NO9 A;  2YII A;  2O6Y A;  1YIS A;  4C5R A;  4NSL A;  2O7D A;  1HY0 A; 
#chains in the Genus database with same CATH topology
 2LKM B;  3U44 A;  3RRP A;  1FUR A;  2BE5 D;  3GZH A;  1XMD A;  5H8W A;  2PFM A;  3H0G A;  3EZE A;  4QIW A;  2O7B A;  2FUS A;  2CW0 D;  3CQZ A;  1SFO A;  5M0I A;  3GTQ A;  2A6H D;  1RE5 A;  1IW7 D;  4ADL A;  1K83 A;  1I0A A;  3UNV A;  4CEH A;  1XL8 A;  2PTQ A;  2JA6 A;  3R6Y A;  4EFC A;  2FEL A;  1T6J A;  1I3Q A;  2YU9 A;  4EEI A;  1I6V D;  1J3U A;  2R93 A;  4APB A;  3QBP A;  2MX9 A;  4HGV A;  1Y1V A;  4FBS A;  3R6Q A;  1GKJ A;  2HVG A;  2F5J A;  2O7F A;  5EYV A;  1VDK A;  1TWF A;  1WCM A;  4C2M A;  4FFX A;  1Y2M A;  1TWC A;  1Q5N A;  3OCF A;  4FLC A;  3OCE A;  3RD8 A;  4V2Q A;  2LYI A;  1DCN A;  2JA5 A;  4C5U A;  2VD6 A;  3GTM A;  1XMC A;  2RJS A;  2X0O A;  3LR6 A;  1TJW A;  3C8T A;  1Y1W A;  2VSF A;  1R9T A;  3E04 A;  2O5J D;  1YNJ D;  2VK9 A;  3CRW 1;  2EZA A;  3EZB A;  1B8F A;  1YNN D;  2NYN A;  3FKI A;  3KDY A;  3EZA A;  2VUM A;  4NLE A;  1XWO A;  2R7Z A;  2E2I A;  2O78 A;  3R6V A;  3GTK A;  5IZ2 A;  1DOF A;  2JA7 A;  4ADM A;  4A15 A;  1HQM D;  1C3U A;  1AUW A;  1EZB A;  2X0Q A;  1W27 A;  1HY1 A;  2OHY A;  2NVY A;  1FUP A;  3CRV A;  1K62 A;  2X75 A;  2Y0N A;  1FUO A;  2J91 A;  1TWA A;  2A69 D;  2B63 A;  1I50 A;  4C5S A;  1YFM A;  2A6E D;  3GTO A;  5D6B A;  4MX2 A;  5HW2 A;  2FIO A;  2LPI A;  2MX8 A;  2NYF A;  3GTP A;  1FUQ A;  1TJ7 A;  1T6P A;  2PTR A;  2FEN A;  3BHG A;  2VL7 A;  2HRO A;  1TWH A;  2X0P A;  1EB4 A;  1GK2 A;  1U16 A;  1GKM A;  1U15 A;  2MP0 A;  1TJV A;  2K3O A;  2RJR A;  5F92 A;  3GTD A;  2PTS A;  2QGA B;  2EZC A;  2EZB A;  3NZ4 A;  4BAA A;  2K3Q A;  5F91 A;  3GTJ A;  2HWG A;  2E9F A;  2FIP A;  2QVE A;  1JSW A;  3KDZ A;  1XLY A;  4V2R A;  3GTL A;  4CEJ A;  1SMY D;  2N1D B;  2MQA A;  2R92 A;  2E2H A;  1YFE A;  4CQ5 A;  1ZYM A;  2N3E A;  4APA A;  1C3C A;  4WNL A;  4BAB A;  3CZO A;  1K7W A;  1XL7 A;  2O7E A;  1TJU A;  2K3N A;  3U4Q A;  3LRD A;  4CEI A;  3LR2 A;  4C6G A;  3TV2 A;  1GK3 A;  5EYT A;  1EZA A;  1KQ7 A;  2LTH A;  3NO9 A;  1TWG A;  2A68 D;  2LPJ A;  1ZYR D;  2YII A;  3GTG A;  2O6Y A;  1YIS A;  2AQL A;  4C5R A;  5M0J A;  3LR8 A;  2NVX A;  4NSL A;  2O7D A;  1HY0 A; 
#chains in the Genus database with same CATH homology
 3RRP A;  1FUR A;  3GZH A;  2PFM A;  2O7B A;  2FUS A;  1RE5 A;  4ADL A;  1I0A A;  3UNV A;  2PTQ A;  3R6Y A;  4EFC A;  1T6J A;  4EEI A;  1J3U A;  4APB A;  3QBP A;  4HGV A;  3R6Q A;  1GKJ A;  2HVG A;  2O7F A;  5EYV A;  1VDK A;  4FFX A;  1Y2M A;  1Q5N A;  3RD8 A;  3OCF A;  4FLC A;  3OCE A;  1DCN A;  4V2Q A;  4C5U A;  2VD6 A;  2RJS A;  1TJW A;  3C8T A;  3E04 A;  1B8F A;  2NYN A;  3KDY A;  4NLE A;  1XWO A;  2O78 A;  3R6V A;  1DOF A;  4ADM A;  1C3U A;  1AUW A;  1W27 A;  1HY1 A;  2OHY A;  1FUP A;  1K62 A;  2X75 A;  1FUO A;  2J91 A;  4C5S A;  1YFM A;  5D6B A;  4MX2 A;  5HW2 A;  2NYF A;  1FUQ A;  1TJ7 A;  1T6P A;  2PTR A;  3BHG A;  1EB4 A;  1U16 A;  1GK2 A;  1GKM A;  1U15 A;  1TJV A;  2RJR A;  5F92 A;  3GTD A;  2PTS A;  2QGA B;  3NZ4 A;  4BAA A;  5F91 A;  2E9F A;  2QVE A;  3KDZ A;  1JSW A;  4V2R A;  1YFE A;  4CQ5 A;  4APA A;  1C3C A;  4BAB A;  3CZO A;  1K7W A;  2O7E A;  1TJU A;  3TV2 A;  4C6G A;  1GK3 A;  5EYT A;  1KQ7 A;  3NO9 A;  2YII A;  2O6Y A;  1YIS A;  4C5R A;  4NSL A;  2O7D A;  1HY0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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