4V2QA

Ironing out their differences: dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase
Total Genus 249
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
249
sequence length
666
structure length
612
Chain Sequence
b'SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDELQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHETDTLVDRLAEFEKRLSDRLENEMTAVRVLYEVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGF'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMMONIA-LYASE
publication title Ironing Out Their Differences: Dissecting the Structural Determinants of a Phenylalanine Aminomutase and Ammonia Lyase.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 249
structure length 612
sequence length 666
chains with identical sequence B
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2014-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4v2qA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4v2qA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4v2qA02
1TJVA 1EB4A 1FUQA 1Q5NA 3E04A 2HVGA 2RJSA 1T6PA 2OHYA 4APAA 2YIIA 1AUWA 2O7FA 2QVEA 4APBA 3R6VA 3CZOA 4CQ5A 4NLEA 4FFXA 4EFCA 3C8TA 1C3UA 2PTRA 5D6BA 1YISA 4C5UA 1FURA 4HGVA 2PTQA 1Y2MA 2NYNA 3OCEA 3RRPA 1J3UA 2O6YA 1JSWA 1GKJA 1I0AA 3KDZA 1TJ7A 2VD6A 1W27A 2O7BA 4NSLA 3KDYA 2PTSA 3BHGA 4FLCA 5F92A 4ADLA 3R6YA 3NO9A 3R6QA 4BABA 1GKMA 5F91A 2O78A 1DCNA 2PFMA 1DOFA 3RD8A 3TV2A 1XWOA 2O7EA 1YFMA 1TJWA 2E9FA 3GZHA 1C3CA 2QGAB 2X75A 1FUPA 1HY0A 1K7WA 1VDKA 4MX2A 1RE5A 1K62A 1B8FA 4C5SA 1GK3A 4V2RA 2O7DA 3QBPA 5EYTA 4C6GA 2RJRA 2J91A 1HY1A 3NZ4A 3OCFA 1YFEA 4C5RA 1GK2A 2FUSA 4EEIA 4BAAA 1TJUA 4ADMA 5EYVA 1U16A 2NYFA 1KQ7A 3GTDA 1FUOA 3UNVA 1T6JA 1U15A 5HW2A 4V2QA
chains in the Genus database with same CATH superfamily
2LTHA 2EZBA 2Y0NA 2X0OA 4C2MA 3CRVA 1TJVA 2EZAA 1EB4A 1FUQA 1Q5NA 1XMDA 3E04A 2R92A 2HVGA 2RJSA 1YNND 1T6PA 2OHYA 4APAA 2YIIA 3GTMA 3LRDA 2K3NA 1AUWA 1WCMA 2O7FA 2O5JD 2QVEA 4APBA 1EZAA 3R6VA 3CZOA 4CQ5A 1EZBA 1TWCA 4FFXA 1SMYD 2MX9A 4NLEA 3EZBA 1XL7A 4EFCA 3C8TA 1C3UA 2PTRA 5D6BA 1K83A 2FELA 2HWGA 4C5UA 2BE5D 1YISA 2JA6A 1Y1VA 1FURA 4HGVA 2FIPA 2PTQA 1Y2MA 2FIOA 1SFOA 2NYNA 3CRW1 3OCEA 2VUMA 2JA7A 3RRPA 1J3UA 2O6YA 1JSWA 2N1DB 1GKJA 2MP0A 1ZYMA 2VSFA 5H8WA 2MX8A 3CQZA 1I0AA 3KDZA 2FENA 1TWHA 1Y1WA 2A69D 2EZCA 1TJ7A 2VD6A 2LYIA 1YNJD 1W27A 4CEIA 3U44A 5F92A 3U4QA 1I6VD 2O7BA 3GTKA 2X0PA 4NSLA 2LKMB 3FKIA 3GTJA 3KDYA 2PTSA 2CW0D 3EZEA 1I50A 2JA5A 3BHGA 2X0QA 4FLCA 4ADLA 2VL7A 4FBSA 3R6YA 3NO9A 3R6QA 4BABA 1GKMA 2A68D 3GTOA 5F91A 2O78A 1DCNA 2PFMA 1DOFA 2E2HA 3RD8A 3TV2A 1XWOA 3EZAA 3LR8A 1YFMA 2R93A 2O7EA 1I3QA 4A15A 2N3EA 1TJWA 3H0GA 1XMCA 2E9FA 2VK9A 5IZ2A 1HQMD 2YU9A 1TWAA 1C3CA 3GZHA 2QGAB 2X75A 1FUPA 1HY0A 1K7WA 1IW7D 2A6ED 1VDKA 4MX2A 1RE5A 1K62A 3GTGA 1B8FA 3GTPA 3GTLA 2F5JA 3LR6A 4C5SA 1GK3A 4CEJA 2E2IA 4WNLA 4V2RA 2O7DA 3QBPA 5EYTA 4C6GA 2RJRA 2LPJA 2J91A 2K3OA 5M0IA 1HY1A 5M0JA 1XLYA 1TWGA 3NZ4A 3OCFA 1YFEA 4C5RA 3LR2A 1ZYRD 2R7ZA 1GK2A 2FUSA 4EEIA 4QIWA 1XL8A 4BAAA 1TJUA 4ADMA 2MQAA 5EYVA 4CEHA 1U16A 1R9TA 2B63A 2NYFA 2NVYA 1KQ7A 3GTDA 2NVXA 1FUOA 2A6HD 2HROA 3UNVA 1T6JA 1U15A 2K3QA 1TWFA 5HW2A 4V2QA 2AQLA 3GTQA 2LPIA
chains in the Genus database with same CATH topology
1TJVA 1EB4A 1FUQA 1Q5NA 3E04A 2HVGA 2RJSA 1T6PA 2OHYA 4APAA 2YIIA 1AUWA 2O7FA 2QVEA 4APBA 3R6VA 3CZOA 4CQ5A 4NLEA 4FFXA 4EFCA 3C8TA 1C3UA 2PTRA 5D6BA 1YISA 4C5UA 1FURA 4HGVA 2PTQA 1Y2MA 2NYNA 3OCEA 3RRPA 1J3UA 2O6YA 1JSWA 1GKJA 1I0AA 3KDZA 1TJ7A 2VD6A 1W27A 2O7BA 4NSLA 3KDYA 2PTSA 3BHGA 4FLCA 5F92A 4ADLA 3R6YA 3NO9A 3R6QA 4BABA 1GKMA 5F91A 2O78A 1DCNA 2PFMA 1DOFA 3RD8A 3TV2A 1XWOA 2O7EA 1YFMA 1TJWA 2E9FA 3GZHA 1C3CA 2QGAB 2X75A 1FUPA 1HY0A 1K7WA 1VDKA 4MX2A 1RE5A 1K62A 1B8FA 4C5SA 1GK3A 4V2RA 2O7DA 3QBPA 5EYTA 4C6GA 2RJRA 2J91A 1HY1A 3NZ4A 3OCFA 1YFEA 4C5RA 1GK2A 2FUSA 4EEIA 4BAAA 1TJUA 4ADMA 5EYVA 1U16A 2NYFA 1KQ7A 3GTDA 1FUOA 3UNVA 1T6JA 1U15A 5HW2A 4V2QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TJV A;  1EB4 A;  1FUQ A;  1Q5N A;  3E04 A;  2HVG A;  2RJS A;  1T6P A;  2OHY A;  4APA A;  2YII A;  1AUW A;  2O7F A;  2QVE A;  4APB A;  3R6V A;  3CZO A;  4CQ5 A;  4NLE A;  4FFX A;  4EFC A;  3C8T A;  1C3U A;  2PTR A;  5D6B A;  1YIS A;  4C5U A;  1FUR A;  4HGV A;  2PTQ A;  1Y2M A;  2NYN A;  3OCE A;  3RRP A;  1J3U A;  2O6Y A;  1JSW A;  1GKJ A;  1I0A A;  3KDZ A;  1TJ7 A;  2VD6 A;  1W27 A;  2O7B A;  4NSL A;  3KDY A;  2PTS A;  3BHG A;  4FLC A;  5F92 A;  4ADL A;  3R6Y A;  3NO9 A;  3R6Q A;  4BAB A;  1GKM A;  5F91 A;  2O78 A;  1DCN A;  2PFM A;  1DOF A;  3RD8 A;  3TV2 A;  1XWO A;  2O7E A;  1YFM A;  1TJW A;  2E9F A;  3GZH A;  1C3C A;  2QGA B;  2X75 A;  1FUP A;  1HY0 A;  1K7W A;  1VDK A;  4MX2 A;  1RE5 A;  1K62 A;  1B8F A;  4C5S A;  1GK3 A;  4V2R A;  2O7D A;  3QBP A;  5EYT A;  4C6G A;  2RJR A;  2J91 A;  1HY1 A;  3NZ4 A;  3OCF A;  1YFE A;  4C5R A;  1GK2 A;  2FUS A;  4EEI A;  4BAA A;  1TJU A;  4ADM A;  5EYV A;  1U16 A;  2NYF A;  1KQ7 A;  3GTD A;  1FUO A;  3UNV A;  1T6J A;  1U15 A;  5HW2 A;  4V2Q A; 
#chains in the Genus database with same CATH topology
 2LTH A;  2EZB A;  2Y0N A;  2X0O A;  4C2M A;  3CRV A;  1TJV A;  2EZA A;  1EB4 A;  1FUQ A;  1Q5N A;  1XMD A;  3E04 A;  2R92 A;  2HVG A;  2RJS A;  1YNN D;  1T6P A;  2OHY A;  4APA A;  2YII A;  3GTM A;  3LRD A;  2K3N A;  1AUW A;  1WCM A;  2O7F A;  2O5J D;  2QVE A;  4APB A;  1EZA A;  3R6V A;  3CZO A;  4CQ5 A;  1EZB A;  1TWC A;  4FFX A;  1SMY D;  2MX9 A;  4NLE A;  3EZB A;  1XL7 A;  4EFC A;  3C8T A;  1C3U A;  2PTR A;  5D6B A;  1K83 A;  2FEL A;  2HWG A;  4C5U A;  2BE5 D;  1YIS A;  2JA6 A;  1Y1V A;  1FUR A;  4HGV A;  2FIP A;  2PTQ A;  1Y2M A;  2FIO A;  1SFO A;  2NYN A;  3CRW 1;  3OCE A;  2VUM A;  2JA7 A;  3RRP A;  1J3U A;  2O6Y A;  1JSW A;  2N1D B;  1GKJ A;  2MP0 A;  1ZYM A;  2VSF A;  5H8W A;  2MX8 A;  3CQZ A;  1I0A A;  3KDZ A;  2FEN A;  1TWH A;  1Y1W A;  2A69 D;  2EZC A;  1TJ7 A;  2VD6 A;  2LYI A;  1YNJ D;  1W27 A;  4CEI A;  3U44 A;  5F92 A;  3U4Q A;  1I6V D;  2O7B A;  3GTK A;  2X0P A;  4NSL A;  2LKM B;  3FKI A;  3GTJ A;  3KDY A;  2PTS A;  2CW0 D;  3EZE A;  1I50 A;  2JA5 A;  3BHG A;  2X0Q A;  4FLC A;  4ADL A;  2VL7 A;  4FBS A;  3R6Y A;  3NO9 A;  3R6Q A;  4BAB A;  1GKM A;  2A68 D;  3GTO A;  5F91 A;  2O78 A;  1DCN A;  2PFM A;  1DOF A;  2E2H A;  3RD8 A;  3TV2 A;  1XWO A;  3EZA A;  3LR8 A;  1YFM A;  2R93 A;  2O7E A;  1I3Q A;  4A15 A;  2N3E A;  1TJW A;  3H0G A;  1XMC A;  2E9F A;  2VK9 A;  5IZ2 A;  1HQM D;  2YU9 A;  1TWA A;  1C3C A;  3GZH A;  2QGA B;  2X75 A;  1FUP A;  1HY0 A;  1K7W A;  1IW7 D;  2A6E D;  1VDK A;  4MX2 A;  1RE5 A;  1K62 A;  3GTG A;  1B8F A;  3GTP A;  3GTL A;  2F5J A;  3LR6 A;  4C5S A;  1GK3 A;  4CEJ A;  2E2I A;  4WNL A;  4V2R A;  2O7D A;  3QBP A;  5EYT A;  4C6G A;  2RJR A;  2LPJ A;  2J91 A;  2K3O A;  5M0I A;  1HY1 A;  5M0J A;  1XLY A;  1TWG A;  3NZ4 A;  3OCF A;  1YFE A;  4C5R A;  3LR2 A;  1ZYR D;  2R7Z A;  1GK2 A;  2FUS A;  4EEI A;  4QIW A;  1XL8 A;  4BAA A;  1TJU A;  4ADM A;  2MQA A;  5EYV A;  4CEH A;  1U16 A;  1R9T A;  2B63 A;  2NYF A;  2NVY A;  1KQ7 A;  3GTD A;  2NVX A;  1FUO A;  2A6H D;  2HRO A;  3UNV A;  1T6J A;  1U15 A;  2K3Q A;  1TWF A;  5HW2 A;  4V2Q A;  2AQL A;  3GTQ A;  2LPI A; 
#chains in the Genus database with same CATH homology
 1TJV A;  1EB4 A;  1FUQ A;  1Q5N A;  3E04 A;  2HVG A;  2RJS A;  1T6P A;  2OHY A;  4APA A;  2YII A;  1AUW A;  2O7F A;  2QVE A;  4APB A;  3R6V A;  3CZO A;  4CQ5 A;  4NLE A;  4FFX A;  4EFC A;  3C8T A;  1C3U A;  2PTR A;  5D6B A;  1YIS A;  4C5U A;  1FUR A;  4HGV A;  2PTQ A;  1Y2M A;  2NYN A;  3OCE A;  3RRP A;  1J3U A;  2O6Y A;  1JSW A;  1GKJ A;  1I0A A;  3KDZ A;  1TJ7 A;  2VD6 A;  1W27 A;  2O7B A;  4NSL A;  3KDY A;  2PTS A;  3BHG A;  4FLC A;  5F92 A;  4ADL A;  3R6Y A;  3NO9 A;  3R6Q A;  4BAB A;  1GKM A;  5F91 A;  2O78 A;  1DCN A;  2PFM A;  1DOF A;  3RD8 A;  3TV2 A;  1XWO A;  2O7E A;  1YFM A;  1TJW A;  2E9F A;  3GZH A;  1C3C A;  2QGA B;  2X75 A;  1FUP A;  1HY0 A;  1K7W A;  1VDK A;  4MX2 A;  1RE5 A;  1K62 A;  1B8F A;  4C5S A;  1GK3 A;  4V2R A;  2O7D A;  3QBP A;  5EYT A;  4C6G A;  2RJR A;  2J91 A;  1HY1 A;  3NZ4 A;  3OCF A;  1YFE A;  4C5R A;  1GK2 A;  2FUS A;  4EEI A;  4BAA A;  1TJU A;  4ADM A;  5EYV A;  1U16 A;  2NYF A;  1KQ7 A;  3GTD A;  1FUO A;  3UNV A;  1T6J A;  1U15 A;  5HW2 A;  4V2Q A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...