4V2QA

Ironing out their differences: dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase
Total Genus 249
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
249
sequence length
666
structure length
612
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDELQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHETDTLVDRLAEFEKRLSDRLENEMTAVRVLYEVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGF
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Ironing Out Their Differences: Dissecting the Structural Determinants of a Phenylalanine Aminomutase and Ammonia Lyase.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE
total genus 249
structure length 612
sequence length 666
chains with identical sequence B
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2014-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4v2qA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4v2qA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4v2qA02
2E9FA 1C3UA 2O6YA 1HY0A 3KDZA 5HW2A 1TJVA 3TV2A 2FUSA 4MX2A 3NZ4A 1DCNA 1KQ7A 4EFCA 1GK3A 2O7EA 1TJWA 3C8TA 4NLEA 1W27A 5EYVA 1EB4A 3GZHA 1K62A 1TJ7A 1K7WA 3RD8A 1YFEA 3R6VA 4APAA 5F91A 3OCEA 1I0AA 1C3CA 3E04A 1T6JA 1XWOA 1GK2A 2YIIA 2HVGA 2PTRA 2PTQA 3GTDA 4BABA 4BAAA 2RJSA 3NO9A 3R6QA 2O7DA 1FURA 5F92A 2O7FA 1T6PA 2OHYA 3QBPA 1J3UA 4V2RA 2O7BA 4ADLA 2RJRA 2X75A 1FUPA 4V2QA 4FLCA 1GKJA 1AUWA 3RRPA 1HY1A 2PFMA 1U15A 1U16A 4HGVA 1RE5A 2J91A 3OCFA 3BHGA 1DOFA 1FUQA 3R6YA 1Q5NA 1B8FA 1GKMA 4C5UA 1VDKA 5D6BA 2VD6A 5EYTA 4NSLA 4EEIA 2NYFA 2O78A 4C5SA 2NYNA 4ADMA 1YISA 4FFXA 1JSWA 4APBA 3KDYA 4C6GA 1Y2MA 1FUOA 3CZOA 2PTSA 1YFMA 1TJUA 2QGAB 3UNVA 4CQ5A 4C5RA 2QVEA
chains in the Genus database with same CATH superfamily
2E9FA 1C3UA 2CW0D 2LPJA 1HY0A 2O6YA 3KDZA 5HW2A 1I3QA 1HQMD 3U4QA 1TJVA 3TV2A 2FUSA 2O5JD 4MX2A 3NZ4A 2MX8A 1DCNA 1KQ7A 4EFCA 1GK3A 2O7EA 2AQLA 3GTOA 2FENA 2R92A 1TJWA 2MP0A 3C8TA 1EZBA 4NLEA 1W27A 2N1DB 2VL7A 2JA6A 1ZYRD 1R9TA 5EYVA 1EB4A 3GZHA 1K62A 1TJ7A 2R7ZA 1K7WA 3EZBA 3RD8A 2VSFA 3GTMA 1YFEA 3R6VA 4APAA 5F91A 3OCEA 2VK9A 2YU9A 1C3CA 1I0AA 3E04A 1XL8A 2FIOA 1YNND 1T6JA 1SMYD 1TWHA 1XWOA 3CRW1 1GK2A 2YIIA 2LPIA 2HVGA 2PTRA 2X0PA 2PTQA 3GTDA 4BABA 4BAAA 4APBA 1K83A 2RJSA 2A6HD 3NO9A 1I6VD 3GTJA 1XMCA 2MQAA 3R6QA 2O7DA 4WNLA 1FURA 5F92A 2LYIA 5M0IA 2O7FA 1T6PA 2OHYA 3QBPA 1J3UA 2MX9A 4V2RA 3GTLA 2JA5A 2O7BA 4ADLA 2RJRA 2X75A 1FUPA 4V2QA 2VUMA 4FLCA 4FBSA 4QIWA 1SFOA 1GKJA 3GTQA 1AUWA 3GTPA 1EZAA 3RRPA 1I50A 4C2MA 1Y1WA 1HY1A 3CRVA 1Y1VA 2PFMA 1ZYMA 5H8WA 1U15A 2X0QA 1U16A 4HGVA 2EZAA 1RE5A 2E2IA 2J91A 3GTGA 2K3OA 3BHGA 3OCFA 2NVYA 2F5JA 1DOFA 1FUQA 3U44A 3R6YA 1Q5NA 2BE5D 3H0GA 2E2HA 2R93A 2QVEA 4CEIA 1TWAA 1B8FA 1GKMA 2K3QA 2K3NA 4C5UA 1VDKA 3GTKA 2HROA 5D6BA 5M0JA 2VD6A 2HWGA 2B63A 5EYTA 4NSLA 4EEIA 2A69D 2LTHA 1XL7A 3EZEA 2FIPA 2NYFA 2O78A 4C5SA 4A15A 2N3EA 2A6ED 1TWCA 2NYNA 1WCMA 4ADMA 1YISA 4FFXA 5IZ2A 1JSWA 2EZBA 3LR6A 3KDYA 4C6GA 1TWGA 3EZAA 2NVXA 1Y2MA 3CQZA 3LRDA 2EZCA 2X0OA 2JA7A 1FUOA 1XLYA 3CZOA 2Y0NA 2LKMB 3FKIA 1YNJD 2PTSA 3LR2A 2FELA 1XMDA 1YFMA 1IW7D 1TJUA 2QGAB 4CEHA 3UNVA 3LR8A 4CQ5A 4CEJA 4C5RA 2A68D 1TWFA
chains in the Genus database with same CATH topology
2E9FA 1C3UA 2O6YA 1HY0A 3KDZA 5HW2A 1TJVA 3TV2A 2FUSA 4MX2A 3NZ4A 1DCNA 1KQ7A 4EFCA 1GK3A 2O7EA 1TJWA 3C8TA 4NLEA 1W27A 5EYVA 1EB4A 3GZHA 1K62A 1TJ7A 1K7WA 3RD8A 1YFEA 3R6VA 4APAA 5F91A 3OCEA 1I0AA 1C3CA 3E04A 1T6JA 1XWOA 1GK2A 2YIIA 2HVGA 2PTRA 2PTQA 3GTDA 4BABA 4BAAA 2RJSA 3NO9A 3R6QA 2O7DA 1FURA 5F92A 2O7FA 1T6PA 2OHYA 3QBPA 1J3UA 4V2RA 2O7BA 4ADLA 2RJRA 2X75A 1FUPA 4V2QA 4FLCA 1GKJA 1AUWA 3RRPA 1HY1A 2PFMA 1U15A 1U16A 4HGVA 1RE5A 2J91A 3OCFA 3BHGA 1DOFA 1FUQA 3R6YA 1Q5NA 1B8FA 1GKMA 4C5UA 1VDKA 5D6BA 2VD6A 5EYTA 4NSLA 4EEIA 2NYFA 2O78A 4C5SA 2NYNA 4ADMA 1YISA 4FFXA 1JSWA 4APBA 3KDYA 4C6GA 1Y2MA 1FUOA 3CZOA 2PTSA 1YFMA 1TJUA 2QGAB 3UNVA 4CQ5A 4C5RA 2QVEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2E9F A;  1C3U A;  2O6Y A;  1HY0 A;  3KDZ A;  5HW2 A;  1TJV A;  3TV2 A;  2FUS A;  4MX2 A;  3NZ4 A;  1DCN A;  1KQ7 A;  4EFC A;  1GK3 A;  2O7E A;  1TJW A;  3C8T A;  4NLE A;  1W27 A;  5EYV A;  1EB4 A;  3GZH A;  1K62 A;  1TJ7 A;  1K7W A;  3RD8 A;  1YFE A;  3R6V A;  4APA A;  5F91 A;  3OCE A;  1I0A A;  1C3C A;  3E04 A;  1T6J A;  1XWO A;  1GK2 A;  2YII A;  2HVG A;  2PTR A;  2PTQ A;  3GTD A;  4BAB A;  4BAA A;  2RJS A;  3NO9 A;  3R6Q A;  2O7D A;  1FUR A;  5F92 A;  2O7F A;  1T6P A;  2OHY A;  3QBP A;  1J3U A;  4V2R A;  2O7B A;  4ADL A;  2RJR A;  2X75 A;  1FUP A;  4V2Q A;  4FLC A;  1GKJ A;  1AUW A;  3RRP A;  1HY1 A;  2PFM A;  1U15 A;  1U16 A;  4HGV A;  1RE5 A;  2J91 A;  3OCF A;  3BHG A;  1DOF A;  1FUQ A;  3R6Y A;  1Q5N A;  1B8F A;  1GKM A;  4C5U A;  1VDK A;  5D6B A;  2VD6 A;  5EYT A;  4NSL A;  4EEI A;  2NYF A;  2O78 A;  4C5S A;  2NYN A;  4ADM A;  1YIS A;  4FFX A;  1JSW A;  4APB A;  3KDY A;  4C6G A;  1Y2M A;  1FUO A;  3CZO A;  2PTS A;  1YFM A;  1TJU A;  2QGA B;  3UNV A;  4CQ5 A;  4C5R A;  2QVE A; 
#chains in the Genus database with same CATH topology
 2E9F A;  1C3U A;  2CW0 D;  2LPJ A;  1HY0 A;  2O6Y A;  3KDZ A;  5HW2 A;  1I3Q A;  1HQM D;  3U4Q A;  1TJV A;  3TV2 A;  2FUS A;  2O5J D;  4MX2 A;  3NZ4 A;  2MX8 A;  1DCN A;  1KQ7 A;  4EFC A;  1GK3 A;  2O7E A;  2AQL A;  3GTO A;  2FEN A;  2R92 A;  1TJW A;  2MP0 A;  3C8T A;  1EZB A;  4NLE A;  1W27 A;  2N1D B;  2VL7 A;  2JA6 A;  1ZYR D;  1R9T A;  5EYV A;  1EB4 A;  3GZH A;  1K62 A;  1TJ7 A;  2R7Z A;  1K7W A;  3EZB A;  3RD8 A;  2VSF A;  3GTM A;  1YFE A;  3R6V A;  4APA A;  5F91 A;  3OCE A;  2VK9 A;  2YU9 A;  1C3C A;  1I0A A;  3E04 A;  1XL8 A;  2FIO A;  1YNN D;  1T6J A;  1SMY D;  1TWH A;  1XWO A;  3CRW 1;  1GK2 A;  2YII A;  2LPI A;  2HVG A;  2PTR A;  2X0P A;  2PTQ A;  3GTD A;  4BAB A;  4BAA A;  4APB A;  1K83 A;  2RJS A;  2A6H D;  3NO9 A;  1I6V D;  3GTJ A;  1XMC A;  2MQA A;  3R6Q A;  2O7D A;  4WNL A;  1FUR A;  5F92 A;  2LYI A;  5M0I A;  2O7F A;  1T6P A;  2OHY A;  3QBP A;  1J3U A;  2MX9 A;  4V2R A;  3GTL A;  2JA5 A;  2O7B A;  4ADL A;  2RJR A;  2X75 A;  1FUP A;  4V2Q A;  2VUM A;  4FLC A;  4FBS A;  4QIW A;  1SFO A;  1GKJ A;  3GTQ A;  1AUW A;  3GTP A;  1EZA A;  3RRP A;  1I50 A;  4C2M A;  1Y1W A;  1HY1 A;  3CRV A;  1Y1V A;  2PFM A;  1ZYM A;  5H8W A;  1U15 A;  2X0Q A;  1U16 A;  4HGV A;  2EZA A;  1RE5 A;  2E2I A;  2J91 A;  3GTG A;  2K3O A;  3BHG A;  3OCF A;  2NVY A;  2F5J A;  1DOF A;  1FUQ A;  3U44 A;  3R6Y A;  1Q5N A;  2BE5 D;  3H0G A;  2E2H A;  2R93 A;  2QVE A;  4CEI A;  1TWA A;  1B8F A;  1GKM A;  2K3Q A;  2K3N A;  4C5U A;  1VDK A;  3GTK A;  2HRO A;  5D6B A;  5M0J A;  2VD6 A;  2HWG A;  2B63 A;  5EYT A;  4NSL A;  4EEI A;  2A69 D;  2LTH A;  1XL7 A;  3EZE A;  2FIP A;  2NYF A;  2O78 A;  4C5S A;  4A15 A;  2N3E A;  2A6E D;  1TWC A;  2NYN A;  1WCM A;  4ADM A;  1YIS A;  4FFX A;  5IZ2 A;  1JSW A;  2EZB A;  3LR6 A;  3KDY A;  4C6G A;  1TWG A;  3EZA A;  2NVX A;  1Y2M A;  3CQZ A;  3LRD A;  2EZC A;  2X0O A;  2JA7 A;  1FUO A;  1XLY A;  3CZO A;  2Y0N A;  2LKM B;  3FKI A;  1YNJ D;  2PTS A;  3LR2 A;  2FEL A;  1XMD A;  1YFM A;  1IW7 D;  1TJU A;  2QGA B;  4CEH A;  3UNV A;  3LR8 A;  4CQ5 A;  4CEJ A;  4C5R A;  2A68 D;  1TWF A; 
#chains in the Genus database with same CATH homology
 2E9F A;  1C3U A;  2O6Y A;  1HY0 A;  3KDZ A;  5HW2 A;  1TJV A;  3TV2 A;  2FUS A;  4MX2 A;  3NZ4 A;  1DCN A;  1KQ7 A;  4EFC A;  1GK3 A;  2O7E A;  1TJW A;  3C8T A;  4NLE A;  1W27 A;  5EYV A;  1EB4 A;  3GZH A;  1K62 A;  1TJ7 A;  1K7W A;  3RD8 A;  1YFE A;  3R6V A;  4APA A;  5F91 A;  3OCE A;  1I0A A;  1C3C A;  3E04 A;  1T6J A;  1XWO A;  1GK2 A;  2YII A;  2HVG A;  2PTR A;  2PTQ A;  3GTD A;  4BAB A;  4BAA A;  2RJS A;  3NO9 A;  3R6Q A;  2O7D A;  1FUR A;  5F92 A;  2O7F A;  1T6P A;  2OHY A;  3QBP A;  1J3U A;  4V2R A;  2O7B A;  4ADL A;  2RJR A;  2X75 A;  1FUP A;  4V2Q A;  4FLC A;  1GKJ A;  1AUW A;  3RRP A;  1HY1 A;  2PFM A;  1U15 A;  1U16 A;  4HGV A;  1RE5 A;  2J91 A;  3OCF A;  3BHG A;  1DOF A;  1FUQ A;  3R6Y A;  1Q5N A;  1B8F A;  1GKM A;  4C5U A;  1VDK A;  5D6B A;  2VD6 A;  5EYT A;  4NSL A;  4EEI A;  2NYF A;  2O78 A;  4C5S A;  2NYN A;  4ADM A;  1YIS A;  4FFX A;  1JSW A;  4APB A;  3KDY A;  4C6G A;  1Y2M A;  1FUO A;  3CZO A;  2PTS A;  1YFM A;  1TJU A;  2QGA B;  3UNV A;  4CQ5 A;  4C5R A;  2QVE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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