4V2QA

Ironing out their differences: dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase
Total Genus 249
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
249
sequence length
666
structure length
612
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDELQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHETDTLVDRLAEFEKRLSDRLENEMTAVRVLYEVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE
publication title Ironing Out Their Differences: Dissecting the Structural Determinants of a Phenylalanine Aminomutase and Ammonia Lyase.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
total genus 249
structure length 612
sequence length 666
chains with identical sequence B
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2014-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4v2qA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4v2qA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4v2qA02
2O7EA 3GTDA 1YISA 1GKMA 3QBPA 1C3CA 4CQ5A 4C5UA 1GK3A 3R6YA 1Q5NA 1T6JA 1W27A 5EYTA 4ADLA 4APBA 5F91A 5HW2A 1AUWA 4C5RA 2J91A 4APAA 1XWOA 3BHGA 1J3UA 1DOFA 4MX2A 3R6VA 3C8TA 2VD6A 1FURA 1YFEA 3CZOA 1K62A 5F92A 1I0AA 5EYVA 3KDYA 1KQ7A 4C5SA 2NYNA 3RRPA 4NLEA 1GKJA 1FUQA 2PFMA 1VDKA 2X75A 3GZHA 4NSLA 4C6GA 4ADMA 1YFMA 2RJSA 2QGAB 1FUPA 1DCNA 1HY0A 1TJUA 2PTSA 4EEIA 1JSWA 2O6YA 3RD8A 1K7WA 3KDZA 1EB4A 3OCFA 2O78A 3TV2A 2O7FA 4V2RA 2E9FA 2PTRA 2OHYA 4HGVA 4BAAA 3OCEA 2FUSA 1GK2A 1TJVA 2O7BA 2HVGA 1U15A 4FFXA 3R6QA 3NZ4A 3E04A 1B8FA 1TJWA 2PTQA 1FUOA 1Y2MA 5D6BA 4BABA 4EFCA 1T6PA 1TJ7A 2NYFA 2YIIA 3UNVA 2QVEA 1U16A 2O7DA 3NO9A 1C3UA 2RJRA 4V2QA 1HY1A 4FLCA 1RE5A
chains in the Genus database with same CATH superfamily
2Y0NA 2O7EA 3GTDA 1YISA 1GKMA 3QBPA 2LTHA 1C3CA 4CQ5A 4C5UA 2MQAA 1GK3A 3R6YA 3GTGA 1Q5NA 1T6JA 3LR8A 1SFOA 1W27A 5EYTA 2F5JA 4ADLA 4APBA 5F91A 5HW2A 2EZAA 2HWGA 1AUWA 4C5RA 2E2HA 1YNND 5M0IA 2AQLA 1TWAA 2J91A 4APAA 3GTMA 2X0PA 1XWOA 3BHGA 1J3UA 2JA6A 1TWGA 2A69D 3U44A 1DOFA 1Y1VA 1XMDA 4MX2A 3R6VA 1SMYD 1YNJD 2X0OA 5IZ2A 1I6VD 2NVXA 2K3NA 3C8TA 2VD6A 3U4QA 3CRW1 3CRVA 1FURA 1YFEA 3CZOA 3LR2A 2O5JD 1K62A 5F92A 3FKIA 2A6ED 2YU9A 1ZYRD 1XMCA 1I0AA 1I3QA 1ZYMA 2LKMB 3EZAA 3KDYA 5EYVA 1KQ7A 4C5SA 2NYNA 3RRPA 4NLEA 5H8WA 1GKJA 4QIWA 2LPIA 1FUQA 1I50A 4A15A 2PFMA 2EZCA 2LYIA 1R9TA 2R7ZA 2EZBA 1VDKA 2X75A 3GZHA 2FELA 2B63A 4NSLA 4C6GA 4ADMA 1YFMA 2RJSA 2FENA 2QGAB 3GTQA 1XL7A 3EZBA 2MX9A 4CEIA 1DCNA 1FUPA 1HY0A 1TJUA 2PTSA 4WNLA 1IW7D 2FIPA 1TWHA 4EEIA 1JSWA 2O6YA 2X0QA 3RD8A 1K7WA 2VK9A 3GTJA 3KDZA 1TWFA 1EB4A 3OCFA 3GTPA 2O78A 1EZBA 2LPJA 3TV2A 2O7FA 2A68D 4V2RA 3H0GA 2R92A 2E9FA 3LR6A 2PTRA 2R93A 2HROA 2OHYA 4HGVA 2VL7A 4FBSA 3GTLA 4BAAA 3OCEA 2FUSA 2MX8A 1EZAA 2CW0D 1GK2A 2A6HD 3LRDA 2JA5A 1HQMD 1TJVA 2O7BA 4C2MA 4CEHA 3GTKA 2VUMA 2HVGA 2N3EA 1U15A 4FFXA 3R6QA 3NZ4A 3E04A 1B8FA 1TJWA 5M0JA 2N1DB 2PTQA 1FUOA 2K3QA 2VSFA 1Y2MA 2E2IA 5D6BA 4BABA 1WCMA 4EFCA 2FIOA 1T6PA 1TWCA 1TJ7A 2YIIA 2NYFA 3UNVA 2QVEA 1U16A 2O7DA 3NO9A 1XLYA 1C3UA 2RJRA 2JA7A 2BE5D 1Y1WA 2MP0A 2K3OA 2NVYA 4V2QA 1K83A 1HY1A 1XL8A 4FLCA 3GTOA 1RE5A 4CEJA 3EZEA 3CQZA
chains in the Genus database with same CATH topology
2O7EA 3GTDA 1YISA 1GKMA 3QBPA 1C3CA 4CQ5A 4C5UA 1GK3A 3R6YA 1Q5NA 1T6JA 1W27A 5EYTA 4ADLA 4APBA 5F91A 5HW2A 1AUWA 4C5RA 2J91A 4APAA 1XWOA 3BHGA 1J3UA 1DOFA 4MX2A 3R6VA 3C8TA 2VD6A 1FURA 1YFEA 3CZOA 1K62A 5F92A 1I0AA 5EYVA 3KDYA 1KQ7A 4C5SA 2NYNA 3RRPA 4NLEA 1GKJA 1FUQA 2PFMA 1VDKA 2X75A 3GZHA 4NSLA 4C6GA 4ADMA 1YFMA 2RJSA 2QGAB 1FUPA 1DCNA 1HY0A 1TJUA 2PTSA 4EEIA 1JSWA 2O6YA 3RD8A 1K7WA 3KDZA 1EB4A 3OCFA 2O78A 3TV2A 2O7FA 4V2RA 2E9FA 2PTRA 2OHYA 4HGVA 4BAAA 3OCEA 2FUSA 1GK2A 1TJVA 2O7BA 2HVGA 1U15A 4FFXA 3R6QA 3NZ4A 3E04A 1B8FA 1TJWA 2PTQA 1FUOA 1Y2MA 5D6BA 4BABA 4EFCA 1T6PA 1TJ7A 2NYFA 2YIIA 3UNVA 2QVEA 1U16A 2O7DA 3NO9A 1C3UA 2RJRA 4V2QA 1HY1A 4FLCA 1RE5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2O7E A;  3GTD A;  1YIS A;  1GKM A;  3QBP A;  1C3C A;  4CQ5 A;  4C5U A;  1GK3 A;  3R6Y A;  1Q5N A;  1T6J A;  1W27 A;  5EYT A;  4ADL A;  4APB A;  5F91 A;  5HW2 A;  1AUW A;  4C5R A;  2J91 A;  4APA A;  1XWO A;  3BHG A;  1J3U A;  1DOF A;  4MX2 A;  3R6V A;  3C8T A;  2VD6 A;  1FUR A;  1YFE A;  3CZO A;  1K62 A;  5F92 A;  1I0A A;  5EYV A;  3KDY A;  1KQ7 A;  4C5S A;  2NYN A;  3RRP A;  4NLE A;  1GKJ A;  1FUQ A;  2PFM A;  1VDK A;  2X75 A;  3GZH A;  4NSL A;  4C6G A;  4ADM A;  1YFM A;  2RJS A;  2QGA B;  1FUP A;  1DCN A;  1HY0 A;  1TJU A;  2PTS A;  4EEI A;  1JSW A;  2O6Y A;  3RD8 A;  1K7W A;  3KDZ A;  1EB4 A;  3OCF A;  2O78 A;  3TV2 A;  2O7F A;  4V2R A;  2E9F A;  2PTR A;  2OHY A;  4HGV A;  4BAA A;  3OCE A;  2FUS A;  1GK2 A;  1TJV A;  2O7B A;  2HVG A;  1U15 A;  4FFX A;  3R6Q A;  3NZ4 A;  3E04 A;  1B8F A;  1TJW A;  2PTQ A;  1FUO A;  1Y2M A;  5D6B A;  4BAB A;  4EFC A;  1T6P A;  1TJ7 A;  2NYF A;  2YII A;  3UNV A;  2QVE A;  1U16 A;  2O7D A;  3NO9 A;  1C3U A;  2RJR A;  4V2Q A;  1HY1 A;  4FLC A;  1RE5 A; 
#chains in the Genus database with same CATH topology
 2Y0N A;  2O7E A;  3GTD A;  1YIS A;  1GKM A;  3QBP A;  2LTH A;  1C3C A;  4CQ5 A;  4C5U A;  2MQA A;  1GK3 A;  3R6Y A;  3GTG A;  1Q5N A;  1T6J A;  3LR8 A;  1SFO A;  1W27 A;  5EYT A;  2F5J A;  4ADL A;  4APB A;  5F91 A;  5HW2 A;  2EZA A;  2HWG A;  1AUW A;  4C5R A;  2E2H A;  1YNN D;  5M0I A;  2AQL A;  1TWA A;  2J91 A;  4APA A;  3GTM A;  2X0P A;  1XWO A;  3BHG A;  1J3U A;  2JA6 A;  1TWG A;  2A69 D;  3U44 A;  1DOF A;  1Y1V A;  1XMD A;  4MX2 A;  3R6V A;  1SMY D;  1YNJ D;  2X0O A;  5IZ2 A;  1I6V D;  2NVX A;  2K3N A;  3C8T A;  2VD6 A;  3U4Q A;  3CRW 1;  3CRV A;  1FUR A;  1YFE A;  3CZO A;  3LR2 A;  2O5J D;  1K62 A;  5F92 A;  3FKI A;  2A6E D;  2YU9 A;  1ZYR D;  1XMC A;  1I0A A;  1I3Q A;  1ZYM A;  2LKM B;  3EZA A;  3KDY A;  5EYV A;  1KQ7 A;  4C5S A;  2NYN A;  3RRP A;  4NLE A;  5H8W A;  1GKJ A;  4QIW A;  2LPI A;  1FUQ A;  1I50 A;  4A15 A;  2PFM A;  2EZC A;  2LYI A;  1R9T A;  2R7Z A;  2EZB A;  1VDK A;  2X75 A;  3GZH A;  2FEL A;  2B63 A;  4NSL A;  4C6G A;  4ADM A;  1YFM A;  2RJS A;  2FEN A;  2QGA B;  3GTQ A;  1XL7 A;  3EZB A;  2MX9 A;  4CEI A;  1DCN A;  1FUP A;  1HY0 A;  1TJU A;  2PTS A;  4WNL A;  1IW7 D;  2FIP A;  1TWH A;  4EEI A;  1JSW A;  2O6Y A;  2X0Q A;  3RD8 A;  1K7W A;  2VK9 A;  3GTJ A;  3KDZ A;  1TWF A;  1EB4 A;  3OCF A;  3GTP A;  2O78 A;  1EZB A;  2LPJ A;  3TV2 A;  2O7F A;  2A68 D;  4V2R A;  3H0G A;  2R92 A;  2E9F A;  3LR6 A;  2PTR A;  2R93 A;  2HRO A;  2OHY A;  4HGV A;  2VL7 A;  4FBS A;  3GTL A;  4BAA A;  3OCE A;  2FUS A;  2MX8 A;  1EZA A;  2CW0 D;  1GK2 A;  2A6H D;  3LRD A;  2JA5 A;  1HQM D;  1TJV A;  2O7B A;  4C2M A;  4CEH A;  3GTK A;  2VUM A;  2HVG A;  2N3E A;  1U15 A;  4FFX A;  3R6Q A;  3NZ4 A;  3E04 A;  1B8F A;  1TJW A;  5M0J A;  2N1D B;  2PTQ A;  1FUO A;  2K3Q A;  2VSF A;  1Y2M A;  2E2I A;  5D6B A;  4BAB A;  1WCM A;  4EFC A;  2FIO A;  1T6P A;  1TWC A;  1TJ7 A;  2YII A;  2NYF A;  3UNV A;  2QVE A;  1U16 A;  2O7D A;  3NO9 A;  1XLY A;  1C3U A;  2RJR A;  2JA7 A;  2BE5 D;  1Y1W A;  2MP0 A;  2K3O A;  2NVY A;  4V2Q A;  1K83 A;  1HY1 A;  1XL8 A;  4FLC A;  3GTO A;  1RE5 A;  4CEJ A;  3EZE A;  3CQZ A; 
#chains in the Genus database with same CATH homology
 2O7E A;  3GTD A;  1YIS A;  1GKM A;  3QBP A;  1C3C A;  4CQ5 A;  4C5U A;  1GK3 A;  3R6Y A;  1Q5N A;  1T6J A;  1W27 A;  5EYT A;  4ADL A;  4APB A;  5F91 A;  5HW2 A;  1AUW A;  4C5R A;  2J91 A;  4APA A;  1XWO A;  3BHG A;  1J3U A;  1DOF A;  4MX2 A;  3R6V A;  3C8T A;  2VD6 A;  1FUR A;  1YFE A;  3CZO A;  1K62 A;  5F92 A;  1I0A A;  5EYV A;  3KDY A;  1KQ7 A;  4C5S A;  2NYN A;  3RRP A;  4NLE A;  1GKJ A;  1FUQ A;  2PFM A;  1VDK A;  2X75 A;  3GZH A;  4NSL A;  4C6G A;  4ADM A;  1YFM A;  2RJS A;  2QGA B;  1FUP A;  1DCN A;  1HY0 A;  1TJU A;  2PTS A;  4EEI A;  1JSW A;  2O6Y A;  3RD8 A;  1K7W A;  3KDZ A;  1EB4 A;  3OCF A;  2O78 A;  3TV2 A;  2O7F A;  4V2R A;  2E9F A;  2PTR A;  2OHY A;  4HGV A;  4BAA A;  3OCE A;  2FUS A;  1GK2 A;  1TJV A;  2O7B A;  2HVG A;  1U15 A;  4FFX A;  3R6Q A;  3NZ4 A;  3E04 A;  1B8F A;  1TJW A;  2PTQ A;  1FUO A;  1Y2M A;  5D6B A;  4BAB A;  4EFC A;  1T6P A;  1TJ7 A;  2NYF A;  2YII A;  3UNV A;  2QVE A;  1U16 A;  2O7D A;  3NO9 A;  1C3U A;  2RJR A;  4V2Q A;  1HY1 A;  4FLC A;  1RE5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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