4V2QA

Ironing out their differences: dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase
Total Genus 249
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
249
sequence length
666
structure length
612
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDELQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHETDTLVDRLAEFEKRLSDRLENEMTAVRVLYEVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMMONIA-LYASE
publication title Ironing Out Their Differences: Dissecting the Structural Determinants of a Phenylalanine Aminomutase and Ammonia Lyase.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 249
structure length 612
sequence length 666
chains with identical sequence B
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2014-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4v2qA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4v2qA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4v2qA02
1T6JA 4CQ5A 3C8TA 1YFEA 1U15A 4C6GA 1HY0A 4C5RA 4EFCA 5EYVA 1C3UA 2QGAB 2OHYA 1Y2MA 3NZ4A 2X75A 2J91A 1FUQA 3CZOA 2PTQA 1JSWA 4BABA 1U16A 3OCFA 2O7FA 2PFMA 1FUPA 4V2RA 2E9FA 1GKJA 2PTRA 5EYTA 4ADLA 5HW2A 2QVEA 2VD6A 1EB4A 5F92A 2O6YA 1HY1A 4FFXA 1GK3A 1I0AA 2NYNA 2RJRA 4MX2A 4V2QA 2O7DA 1KQ7A 1K7WA 1RE5A 1TJVA 4FLCA 3GZHA 1VDKA 1YISA 4APBA 4BAAA 1K62A 5D6BA 1XWOA 4APAA 4HGVA 1TJ7A 4NLEA 2O78A 1FUOA 1J3UA 1DCNA 3GTDA 2YIIA 2FUSA 1TJWA 1FURA 1C3CA 5F91A 1TJUA 3R6QA 2HVGA 3RRPA 1YFMA 1GKMA 2NYFA 1W27A 3R6YA 3BHGA 3NO9A 2PTSA 1T6PA 1DOFA 1B8FA 1GK2A 2O7EA 3RD8A 3KDZA 4C5UA 1Q5NA 3UNVA 2RJSA 3KDYA 4C5SA 1AUWA 3QBPA 3TV2A 2O7BA 3R6VA 4ADMA 4EEIA 3OCEA 3E04A 4NSLA
chains in the Genus database with same CATH superfamily
2CW0D 3GTLA 1SFOA 1T6JA 4CQ5A 3C8TA 1XLYA 2BE5D 2A6HD 3LRDA 3U44A 1ZYMA 2LPIA 1YFEA 1U15A 2A69D 4A15A 2F5JA 4C6GA 3CRVA 1HY0A 3EZAA 1EZAA 2X0QA 4C5RA 5EYVA 2LPJA 4EFCA 1C3UA 3GTPA 2QGAB 4WNLA 5M0JA 2OHYA 1K83A 1Y2MA 2LYIA 3NZ4A 2X75A 3LR6A 2J91A 1EZBA 1YNND 1FUQA 2AQLA 2PTQA 3CZOA 4BABA 2Y0NA 1JSWA 1U16A 2HWGA 3OCFA 2NVXA 2R92A 2O7FA 4FBSA 3LR8A 2PFMA 1IW7D 1XL7A 1FUPA 5H8WA 4V2RA 2NVYA 2E9FA 1GKJA 2PTRA 5EYTA 2JA7A 4ADLA 5HW2A 1XL8A 2JA5A 1ZYRD 2QVEA 2N1DB 2K3NA 2E2IA 2MX8A 2VD6A 2YU9A 1EB4A 5F92A 2O6YA 1HY1A 3CQZA 4FFXA 2O5JD 1GK3A 2VL7A 1I0AA 2NYNA 2VUMA 3EZEA 2RJRA 4MX2A 4V2QA 1SMYD 2O7DA 1K7WA 1KQ7A 2VK9A 2EZCA 1RE5A 2X0OA 1TJVA 4FLCA 2B63A 3GZHA 2JA6A 4CEHA 1VDKA 1R9TA 2VSFA 1YISA 4APBA 4BAAA 1I50A 1K62A 3EZBA 5D6BA 1XWOA 1Y1VA 4APAA 1TWFA 4HGVA 1TJ7A 4NLEA 2O78A 1TWCA 1FUOA 1J3UA 1XMCA 1DCNA 3GTDA 2N3EA 2K3OA 3GTOA 2YIIA 2FUSA 1HQMD 1TJWA 1FURA 1C3CA 5F91A 3FKIA 1TJUA 2A68D 3R6QA 2FENA 2X0PA 4QIWA 4C2MA 2HVGA 3U4QA 3RRPA 3CRW1 2R7ZA 1YFMA 1GKMA 1I6VD 5M0IA 2NYFA 2A6ED 1TWGA 1W27A 2LKMB 1I3QA 2FIOA 3GTQA 2E2HA 1YNJD 2MP0A 3BHGA 3R6YA 1TWHA 2FIPA 3LR2A 3NO9A 2FELA 2PTSA 1T6PA 1DOFA 2MX9A 2EZAA 1WCMA 1B8FA 2MQAA 3GTKA 1GK2A 2R93A 1TWAA 2O7EA 3KDZA 3RD8A 4C5UA 1Q5NA 5IZ2A 3GTGA 3UNVA 2HROA 2RJSA 3KDYA 4C5SA 2EZBA 1Y1WA 1AUWA 3QBPA 3TV2A 3GTJA 2K3QA 3H0GA 4CEJA 2O7BA 3R6VA 4ADMA 4CEIA 1XMDA 4EEIA 3OCEA 3E04A 4NSLA 3GTMA 2LTHA
chains in the Genus database with same CATH topology
1T6JA 4CQ5A 3C8TA 1YFEA 1U15A 4C6GA 1HY0A 4C5RA 4EFCA 5EYVA 1C3UA 2QGAB 2OHYA 1Y2MA 3NZ4A 2X75A 2J91A 1FUQA 3CZOA 2PTQA 1JSWA 4BABA 1U16A 3OCFA 2O7FA 2PFMA 1FUPA 4V2RA 2E9FA 1GKJA 2PTRA 5EYTA 4ADLA 5HW2A 2QVEA 2VD6A 1EB4A 5F92A 2O6YA 1HY1A 4FFXA 1GK3A 1I0AA 2NYNA 2RJRA 4MX2A 4V2QA 2O7DA 1KQ7A 1K7WA 1RE5A 1TJVA 4FLCA 3GZHA 1VDKA 1YISA 4APBA 4BAAA 1K62A 5D6BA 1XWOA 4APAA 4HGVA 1TJ7A 4NLEA 2O78A 1FUOA 1J3UA 1DCNA 3GTDA 2YIIA 2FUSA 1TJWA 1FURA 1C3CA 5F91A 1TJUA 3R6QA 2HVGA 3RRPA 1YFMA 1GKMA 2NYFA 1W27A 3R6YA 3BHGA 3NO9A 2PTSA 1T6PA 1DOFA 1B8FA 1GK2A 2O7EA 3RD8A 3KDZA 4C5UA 1Q5NA 3UNVA 2RJSA 3KDYA 4C5SA 1AUWA 3QBPA 3TV2A 2O7BA 3R6VA 4ADMA 4EEIA 3OCEA 3E04A 4NSLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1T6J A;  4CQ5 A;  3C8T A;  1YFE A;  1U15 A;  4C6G A;  1HY0 A;  4C5R A;  4EFC A;  5EYV A;  1C3U A;  2QGA B;  2OHY A;  1Y2M A;  3NZ4 A;  2X75 A;  2J91 A;  1FUQ A;  3CZO A;  2PTQ A;  1JSW A;  4BAB A;  1U16 A;  3OCF A;  2O7F A;  2PFM A;  1FUP A;  4V2R A;  2E9F A;  1GKJ A;  2PTR A;  5EYT A;  4ADL A;  5HW2 A;  2QVE A;  2VD6 A;  1EB4 A;  5F92 A;  2O6Y A;  1HY1 A;  4FFX A;  1GK3 A;  1I0A A;  2NYN A;  2RJR A;  4MX2 A;  4V2Q A;  2O7D A;  1KQ7 A;  1K7W A;  1RE5 A;  1TJV A;  4FLC A;  3GZH A;  1VDK A;  1YIS A;  4APB A;  4BAA A;  1K62 A;  5D6B A;  1XWO A;  4APA A;  4HGV A;  1TJ7 A;  4NLE A;  2O78 A;  1FUO A;  1J3U A;  1DCN A;  3GTD A;  2YII A;  2FUS A;  1TJW A;  1FUR A;  1C3C A;  5F91 A;  1TJU A;  3R6Q A;  2HVG A;  3RRP A;  1YFM A;  1GKM A;  2NYF A;  1W27 A;  3R6Y A;  3BHG A;  3NO9 A;  2PTS A;  1T6P A;  1DOF A;  1B8F A;  1GK2 A;  2O7E A;  3RD8 A;  3KDZ A;  4C5U A;  1Q5N A;  3UNV A;  2RJS A;  3KDY A;  4C5S A;  1AUW A;  3QBP A;  3TV2 A;  2O7B A;  3R6V A;  4ADM A;  4EEI A;  3OCE A;  3E04 A;  4NSL A; 
#chains in the Genus database with same CATH topology
 2CW0 D;  3GTL A;  1SFO A;  1T6J A;  4CQ5 A;  3C8T A;  1XLY A;  2BE5 D;  2A6H D;  3LRD A;  3U44 A;  1ZYM A;  2LPI A;  1YFE A;  1U15 A;  2A69 D;  4A15 A;  2F5J A;  4C6G A;  3CRV A;  1HY0 A;  3EZA A;  1EZA A;  2X0Q A;  4C5R A;  5EYV A;  2LPJ A;  4EFC A;  1C3U A;  3GTP A;  2QGA B;  4WNL A;  5M0J A;  2OHY A;  1K83 A;  1Y2M A;  2LYI A;  3NZ4 A;  2X75 A;  3LR6 A;  2J91 A;  1EZB A;  1YNN D;  1FUQ A;  2AQL A;  2PTQ A;  3CZO A;  4BAB A;  2Y0N A;  1JSW A;  1U16 A;  2HWG A;  3OCF A;  2NVX A;  2R92 A;  2O7F A;  4FBS A;  3LR8 A;  2PFM A;  1IW7 D;  1XL7 A;  1FUP A;  5H8W A;  4V2R A;  2NVY A;  2E9F A;  1GKJ A;  2PTR A;  5EYT A;  2JA7 A;  4ADL A;  5HW2 A;  1XL8 A;  2JA5 A;  1ZYR D;  2QVE A;  2N1D B;  2K3N A;  2E2I A;  2MX8 A;  2VD6 A;  2YU9 A;  1EB4 A;  5F92 A;  2O6Y A;  1HY1 A;  3CQZ A;  4FFX A;  2O5J D;  1GK3 A;  2VL7 A;  1I0A A;  2NYN A;  2VUM A;  3EZE A;  2RJR A;  4MX2 A;  4V2Q A;  1SMY D;  2O7D A;  1K7W A;  1KQ7 A;  2VK9 A;  2EZC A;  1RE5 A;  2X0O A;  1TJV A;  4FLC A;  2B63 A;  3GZH A;  2JA6 A;  4CEH A;  1VDK A;  1R9T A;  2VSF A;  1YIS A;  4APB A;  4BAA A;  1I50 A;  1K62 A;  3EZB A;  5D6B A;  1XWO A;  1Y1V A;  4APA A;  1TWF A;  4HGV A;  1TJ7 A;  4NLE A;  2O78 A;  1TWC A;  1FUO A;  1J3U A;  1XMC A;  1DCN A;  3GTD A;  2N3E A;  2K3O A;  3GTO A;  2YII A;  2FUS A;  1HQM D;  1TJW A;  1FUR A;  1C3C A;  5F91 A;  3FKI A;  1TJU A;  2A68 D;  3R6Q A;  2FEN A;  2X0P A;  4QIW A;  4C2M A;  2HVG A;  3U4Q A;  3RRP A;  3CRW 1;  2R7Z A;  1YFM A;  1GKM A;  1I6V D;  5M0I A;  2NYF A;  2A6E D;  1TWG A;  1W27 A;  2LKM B;  1I3Q A;  2FIO A;  3GTQ A;  2E2H A;  1YNJ D;  2MP0 A;  3BHG A;  3R6Y A;  1TWH A;  2FIP A;  3LR2 A;  3NO9 A;  2FEL A;  2PTS A;  1T6P A;  1DOF A;  2MX9 A;  2EZA A;  1WCM A;  1B8F A;  2MQA A;  3GTK A;  1GK2 A;  2R93 A;  1TWA A;  2O7E A;  3KDZ A;  3RD8 A;  4C5U A;  1Q5N A;  5IZ2 A;  3GTG A;  3UNV A;  2HRO A;  2RJS A;  3KDY A;  4C5S A;  2EZB A;  1Y1W A;  1AUW A;  3QBP A;  3TV2 A;  3GTJ A;  2K3Q A;  3H0G A;  4CEJ A;  2O7B A;  3R6V A;  4ADM A;  4CEI A;  1XMD A;  4EEI A;  3OCE A;  3E04 A;  4NSL A;  3GTM A;  2LTH A; 
#chains in the Genus database with same CATH homology
 1T6J A;  4CQ5 A;  3C8T A;  1YFE A;  1U15 A;  4C6G A;  1HY0 A;  4C5R A;  4EFC A;  5EYV A;  1C3U A;  2QGA B;  2OHY A;  1Y2M A;  3NZ4 A;  2X75 A;  2J91 A;  1FUQ A;  3CZO A;  2PTQ A;  1JSW A;  4BAB A;  1U16 A;  3OCF A;  2O7F A;  2PFM A;  1FUP A;  4V2R A;  2E9F A;  1GKJ A;  2PTR A;  5EYT A;  4ADL A;  5HW2 A;  2QVE A;  2VD6 A;  1EB4 A;  5F92 A;  2O6Y A;  1HY1 A;  4FFX A;  1GK3 A;  1I0A A;  2NYN A;  2RJR A;  4MX2 A;  4V2Q A;  2O7D A;  1KQ7 A;  1K7W A;  1RE5 A;  1TJV A;  4FLC A;  3GZH A;  1VDK A;  1YIS A;  4APB A;  4BAA A;  1K62 A;  5D6B A;  1XWO A;  4APA A;  4HGV A;  1TJ7 A;  4NLE A;  2O78 A;  1FUO A;  1J3U A;  1DCN A;  3GTD A;  2YII A;  2FUS A;  1TJW A;  1FUR A;  1C3C A;  5F91 A;  1TJU A;  3R6Q A;  2HVG A;  3RRP A;  1YFM A;  1GKM A;  2NYF A;  1W27 A;  3R6Y A;  3BHG A;  3NO9 A;  2PTS A;  1T6P A;  1DOF A;  1B8F A;  1GK2 A;  2O7E A;  3RD8 A;  3KDZ A;  4C5U A;  1Q5N A;  3UNV A;  2RJS A;  3KDY A;  4C5S A;  1AUW A;  3QBP A;  3TV2 A;  2O7B A;  3R6V A;  4ADM A;  4EEI A;  3OCE A;  3E04 A;  4NSL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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