4C5SA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 267
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
267
sequence length
667
structure length
638
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIAGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHTDTLVDRLAEFEKRLSDRLENEMTAVRVLYEVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMMONIA-LYASE
publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 267
structure length 638
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c5sA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c5sA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c5sA02
4V2RA 1B8FA 5EYTA 3CZOA 2FUSA 4ADLA 3BHGA 5HW2A 1TJ7A 4C5RA 4CQ5A 2O78A 2X75A 2O7BA 1VDKA 2PTRA 1FUQA 2NYFA 1YFEA 3TV2A 4V2QA 3NZ4A 1DOFA 4BABA 4BAAA 3GTDA 3E04A 1YISA 1TJWA 3OCEA 4APBA 1C3UA 2QGAB 3C8TA 1DCNA 1YFMA 1GKMA 2O7EA 4NSLA 2J91A 2HVGA 1XWOA 1HY0A 3R6QA 2O6YA 4EEIA 4C5SA 4NLEA 1TJVA 4FLCA 2PTQA 1FUPA 5F92A 3R6VA 1T6PA 1TJUA 5D6BA 4C5UA 3RRPA 1KQ7A 3OCFA 3QBPA 2OHYA 4ADMA 5F91A 1GK2A 1U16A 3NO9A 5EYVA 1JSWA 3KDYA 4APAA 1K62A 3RD8A 2YIIA 3R6YA 1T6JA 1Q5NA 1AUWA 1GKJA 2RJRA 2RJSA 1RE5A 4C6GA 2O7FA 4FFXA 1J3UA 2QVEA 4EFCA 1K7WA 4HGVA 3KDZA 1FURA 1GK3A 1EB4A 2VD6A 3UNVA 1I0AA 4MX2A 3GZHA 1W27A 1Y2MA 2PTSA 1U15A 1HY1A 1FUOA 1C3CA 2E9FA 2PFMA 2O7DA 2NYNA
chains in the Genus database with same CATH superfamily
3GTJA 4V2RA 1B8FA 2E2IA 2JA6A 2VUMA 5EYTA 3CZOA 2FUSA 2VL7A 4ADLA 3BHGA 5H8WA 5HW2A 1TJ7A 3CRW1 4C5RA 4CQ5A 3LRDA 2HWGA 2O78A 2X75A 2O7BA 1VDKA 2MQAA 2LKMB 2PTRA 1FUQA 2NYFA 1ZYRD 3EZEA 1YFEA 3TV2A 4V2QA 2N3EA 1ZYMA 3NZ4A 2R7ZA 2MX8A 4FBSA 2FIPA 5M0JA 3GTPA 3GTQA 2VSFA 3GTMA 1YNND 1Y1WA 3LR2A 1DOFA 1XLYA 2A6ED 2X0OA 4BABA 3GTLA 4BAAA 1I50A 3GTDA 2JA5A 3E04A 2K3QA 5M0IA 1XMDA 1YISA 1TJWA 3OCEA 2R92A 4APBA 3EZBA 4CEIA 1C3UA 2B63A 2EZBA 2FENA 2QGAB 3C8TA 1DCNA 1YFMA 2LPIA 1Y1VA 1GKMA 2F5JA 1XMCA 1SMYD 2HROA 2O7EA 4NSLA 4QIWA 2FIOA 2J91A 2HVGA 1EZAA 1XWOA 2Y0NA 1HY0A 3R6QA 2K3OA 3LR8A 2CW0D 3CQZA 2X0QA 2O6YA 4EEIA 4WNLA 4C5SA 4NLEA 1EZBA 2LPJA 1TJVA 4FLCA 3U44A 2PTQA 2R93A 1FUPA 3CRVA 4CEHA 5F92A 3R6VA 2E2HA 3FKIA 1T6PA 1TJUA 5D6BA 1SFOA 4C5UA 3RRPA 1KQ7A 3OCFA 3QBPA 4A15A 3U4QA 2LYIA 2OHYA 1R9TA 4ADMA 5F91A 1TWCA 1GK2A 1U16A 3NO9A 5EYVA 1JSWA 3KDYA 2AQLA 2VK9A 2JA7A 4APAA 2NVXA 4C2MA 3GTGA 2YIIA 1K62A 2BE5D 1T6JA 2A68D 3GTKA 1Q5NA 3R6YA 3RD8A 1I3QA 1AUWA 2K3NA 1GKJA 2RJRA 1HQMD 2EZAA 2RJSA 2A69D 1I6VD 1RE5A 5IZ2A 4C6GA 2X0PA 2O7FA 4FFXA 1J3UA 2QVEA 4EFCA 3EZAA 1K7WA 2N1DB 1XL8A 4HGVA 3KDZA 2NVYA 1FURA 1GK3A 1EB4A 2VD6A 3UNVA 1I0AA 1IW7D 3LR6A 4MX2A 2A6HD 2EZCA 4CEJA 3GZHA 2YU9A 1W27A 1Y2MA 2LTHA 2PTSA 1U15A 1WCMA 1HY1A 1FUOA 1C3CA 1TWGA 2MX9A 3GTOA 1YNJD 2MP0A 1XL7A 1TWHA 3H0GA 2E9FA 2O5JD 1TWAA 1K83A 2PFMA 2O7DA 2NYNA 2FELA 1TWFA
chains in the Genus database with same CATH topology
4V2RA 1B8FA 5EYTA 3CZOA 2FUSA 4ADLA 3BHGA 5HW2A 1TJ7A 4C5RA 4CQ5A 2O78A 2X75A 2O7BA 1VDKA 2PTRA 1FUQA 2NYFA 1YFEA 3TV2A 4V2QA 3NZ4A 1DOFA 4BABA 4BAAA 3GTDA 3E04A 1YISA 1TJWA 3OCEA 4APBA 1C3UA 2QGAB 3C8TA 1DCNA 1YFMA 1GKMA 2O7EA 4NSLA 2J91A 2HVGA 1XWOA 1HY0A 3R6QA 2O6YA 4EEIA 4C5SA 4NLEA 1TJVA 4FLCA 2PTQA 1FUPA 5F92A 3R6VA 1T6PA 1TJUA 5D6BA 4C5UA 3RRPA 1KQ7A 3OCFA 3QBPA 2OHYA 4ADMA 5F91A 1GK2A 1U16A 3NO9A 5EYVA 1JSWA 3KDYA 4APAA 1K62A 3RD8A 2YIIA 3R6YA 1T6JA 1Q5NA 1AUWA 1GKJA 2RJRA 2RJSA 1RE5A 4C6GA 2O7FA 4FFXA 1J3UA 2QVEA 4EFCA 1K7WA 4HGVA 3KDZA 1FURA 1GK3A 1EB4A 2VD6A 3UNVA 1I0AA 4MX2A 3GZHA 1W27A 1Y2MA 2PTSA 1U15A 1HY1A 1FUOA 1C3CA 2E9FA 2PFMA 2O7DA 2NYNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4V2R A;  1B8F A;  5EYT A;  3CZO A;  2FUS A;  4ADL A;  3BHG A;  5HW2 A;  1TJ7 A;  4C5R A;  4CQ5 A;  2O78 A;  2X75 A;  2O7B A;  1VDK A;  2PTR A;  1FUQ A;  2NYF A;  1YFE A;  3TV2 A;  4V2Q A;  3NZ4 A;  1DOF A;  4BAB A;  4BAA A;  3GTD A;  3E04 A;  1YIS A;  1TJW A;  3OCE A;  4APB A;  1C3U A;  2QGA B;  3C8T A;  1DCN A;  1YFM A;  1GKM A;  2O7E A;  4NSL A;  2J91 A;  2HVG A;  1XWO A;  1HY0 A;  3R6Q A;  2O6Y A;  4EEI A;  4C5S A;  4NLE A;  1TJV A;  4FLC A;  2PTQ A;  1FUP A;  5F92 A;  3R6V A;  1T6P A;  1TJU A;  5D6B A;  4C5U A;  3RRP A;  1KQ7 A;  3OCF A;  3QBP A;  2OHY A;  4ADM A;  5F91 A;  1GK2 A;  1U16 A;  3NO9 A;  5EYV A;  1JSW A;  3KDY A;  4APA A;  1K62 A;  3RD8 A;  2YII A;  3R6Y A;  1T6J A;  1Q5N A;  1AUW A;  1GKJ A;  2RJR A;  2RJS A;  1RE5 A;  4C6G A;  2O7F A;  4FFX A;  1J3U A;  2QVE A;  4EFC A;  1K7W A;  4HGV A;  3KDZ A;  1FUR A;  1GK3 A;  1EB4 A;  2VD6 A;  3UNV A;  1I0A A;  4MX2 A;  3GZH A;  1W27 A;  1Y2M A;  2PTS A;  1U15 A;  1HY1 A;  1FUO A;  1C3C A;  2E9F A;  2PFM A;  2O7D A;  2NYN A; 
#chains in the Genus database with same CATH topology
 3GTJ A;  4V2R A;  1B8F A;  2E2I A;  2JA6 A;  2VUM A;  5EYT A;  3CZO A;  2FUS A;  2VL7 A;  4ADL A;  3BHG A;  5H8W A;  5HW2 A;  1TJ7 A;  3CRW 1;  4C5R A;  4CQ5 A;  3LRD A;  2HWG A;  2O78 A;  2X75 A;  2O7B A;  1VDK A;  2MQA A;  2LKM B;  2PTR A;  1FUQ A;  2NYF A;  1ZYR D;  3EZE A;  1YFE A;  3TV2 A;  4V2Q A;  2N3E A;  1ZYM A;  3NZ4 A;  2R7Z A;  2MX8 A;  4FBS A;  2FIP A;  5M0J A;  3GTP A;  3GTQ A;  2VSF A;  3GTM A;  1YNN D;  1Y1W A;  3LR2 A;  1DOF A;  1XLY A;  2A6E D;  2X0O A;  4BAB A;  3GTL A;  4BAA A;  1I50 A;  3GTD A;  2JA5 A;  3E04 A;  2K3Q A;  5M0I A;  1XMD A;  1YIS A;  1TJW A;  3OCE A;  2R92 A;  4APB A;  3EZB A;  4CEI A;  1C3U A;  2B63 A;  2EZB A;  2FEN A;  2QGA B;  3C8T A;  1DCN A;  1YFM A;  2LPI A;  1Y1V A;  1GKM A;  2F5J A;  1XMC A;  1SMY D;  2HRO A;  2O7E A;  4NSL A;  4QIW A;  2FIO A;  2J91 A;  2HVG A;  1EZA A;  1XWO A;  2Y0N A;  1HY0 A;  3R6Q A;  2K3O A;  3LR8 A;  2CW0 D;  3CQZ A;  2X0Q A;  2O6Y A;  4EEI A;  4WNL A;  4C5S A;  4NLE A;  1EZB A;  2LPJ A;  1TJV A;  4FLC A;  3U44 A;  2PTQ A;  2R93 A;  1FUP A;  3CRV A;  4CEH A;  5F92 A;  3R6V A;  2E2H A;  3FKI A;  1T6P A;  1TJU A;  5D6B A;  1SFO A;  4C5U A;  3RRP A;  1KQ7 A;  3OCF A;  3QBP A;  4A15 A;  3U4Q A;  2LYI A;  2OHY A;  1R9T A;  4ADM A;  5F91 A;  1TWC A;  1GK2 A;  1U16 A;  3NO9 A;  5EYV A;  1JSW A;  3KDY A;  2AQL A;  2VK9 A;  2JA7 A;  4APA A;  2NVX A;  4C2M A;  3GTG A;  2YII A;  1K62 A;  2BE5 D;  1T6J A;  2A68 D;  3GTK A;  1Q5N A;  3R6Y A;  3RD8 A;  1I3Q A;  1AUW A;  2K3N A;  1GKJ A;  2RJR A;  1HQM D;  2EZA A;  2RJS A;  2A69 D;  1I6V D;  1RE5 A;  5IZ2 A;  4C6G A;  2X0P A;  2O7F A;  4FFX A;  1J3U A;  2QVE A;  4EFC A;  3EZA A;  1K7W A;  2N1D B;  1XL8 A;  4HGV A;  3KDZ A;  2NVY A;  1FUR A;  1GK3 A;  1EB4 A;  2VD6 A;  3UNV A;  1I0A A;  1IW7 D;  3LR6 A;  4MX2 A;  2A6H D;  2EZC A;  4CEJ A;  3GZH A;  2YU9 A;  1W27 A;  1Y2M A;  2LTH A;  2PTS A;  1U15 A;  1WCM A;  1HY1 A;  1FUO A;  1C3C A;  1TWG A;  2MX9 A;  3GTO A;  1YNJ D;  2MP0 A;  1XL7 A;  1TWH A;  3H0G A;  2E9F A;  2O5J D;  1TWA A;  1K83 A;  2PFM A;  2O7D A;  2NYN A;  2FEL A;  1TWF A; 
#chains in the Genus database with same CATH homology
 4V2R A;  1B8F A;  5EYT A;  3CZO A;  2FUS A;  4ADL A;  3BHG A;  5HW2 A;  1TJ7 A;  4C5R A;  4CQ5 A;  2O78 A;  2X75 A;  2O7B A;  1VDK A;  2PTR A;  1FUQ A;  2NYF A;  1YFE A;  3TV2 A;  4V2Q A;  3NZ4 A;  1DOF A;  4BAB A;  4BAA A;  3GTD A;  3E04 A;  1YIS A;  1TJW A;  3OCE A;  4APB A;  1C3U A;  2QGA B;  3C8T A;  1DCN A;  1YFM A;  1GKM A;  2O7E A;  4NSL A;  2J91 A;  2HVG A;  1XWO A;  1HY0 A;  3R6Q A;  2O6Y A;  4EEI A;  4C5S A;  4NLE A;  1TJV A;  4FLC A;  2PTQ A;  1FUP A;  5F92 A;  3R6V A;  1T6P A;  1TJU A;  5D6B A;  4C5U A;  3RRP A;  1KQ7 A;  3OCF A;  3QBP A;  2OHY A;  4ADM A;  5F91 A;  1GK2 A;  1U16 A;  3NO9 A;  5EYV A;  1JSW A;  3KDY A;  4APA A;  1K62 A;  3RD8 A;  2YII A;  3R6Y A;  1T6J A;  1Q5N A;  1AUW A;  1GKJ A;  2RJR A;  2RJS A;  1RE5 A;  4C6G A;  2O7F A;  4FFX A;  1J3U A;  2QVE A;  4EFC A;  1K7W A;  4HGV A;  3KDZ A;  1FUR A;  1GK3 A;  1EB4 A;  2VD6 A;  3UNV A;  1I0A A;  4MX2 A;  3GZH A;  1W27 A;  1Y2M A;  2PTS A;  1U15 A;  1HY1 A;  1FUO A;  1C3C A;  2E9F A;  2PFM A;  2O7D A;  2NYN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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