4C5SA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 267
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
267
sequence length
667
structure length
638
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIAGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHTDTLVDRLAEFEKRLSDRLENEMTAVRVLYEVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMMONIA-LYASE
publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 267
structure length 638
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c5sA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c5sA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c5sA02
4APAA 2NYNA 1RE5A 1JSWA 4ADLA 3BHGA 2X75A 2PTSA 4V2QA 1AUWA 2QGAB 4C5SA 1YISA 3KDZA 1HY1A 5EYVA 3NO9A 4EFCA 2O78A 2O7EA 4V2RA 4HGVA 3KDYA 1YFMA 3QBPA 4APBA 1EB4A 4NLEA 1HY0A 2FUSA 4C5UA 4ADMA 2PTQA 4CQ5A 3E04A 4FLCA 5F91A 3GZHA 4NSLA 5D6BA 2RJSA 1TJVA 1I0AA 2OHYA 1C3CA 3RD8A 3NZ4A 3GTDA 1GK3A 1B8FA 1VDKA 1FURA 3R6YA 3OCEA 2RJRA 2NYFA 2O7FA 2PFMA 4MX2A 1KQ7A 1XWOA 3UNVA 1T6PA 1W27A 2YIIA 5F92A 1K62A 1FUQA 1TJUA 1Q5NA 4C5RA 3C8TA 1C3UA 1K7WA 1U16A 4BABA 2O6YA 2HVGA 3OCFA 1GKMA 2PTRA 5HW2A 1FUOA 1U15A 1FUPA 3TV2A 1J3UA 2E9FA 3R6VA 2VD6A 3CZOA 4EEIA 2QVEA 2O7BA 2J91A 4FFXA 1DOFA 1Y2MA 1TJWA 1GKJA 3R6QA 4C6GA 1YFEA 1DCNA 1TJ7A 3RRPA 1GK2A 2O7DA 1T6JA 4BAAA 5EYTA
chains in the Genus database with same CATH superfamily
4APAA 2NYNA 2BE5D 1RE5A 1JSWA 4ADLA 3BHGA 1WCMA 2X75A 2PTSA 1ZYRD 1XMCA 1TWAA 4V2QA 2YU9A 4C2MA 1SMYD 3CQZA 1AUWA 1XL7A 2QGAB 4C5SA 1XLYA 2MX8A 2N3EA 1YISA 3KDZA 1HY1A 5EYVA 3NO9A 4EFCA 3EZBA 2O78A 2O7EA 2X0OA 2X0QA 2VSFA 2LTHA 4V2RA 4HGVA 2A69D 3KDYA 1YFMA 2X0PA 3QBPA 3U4QA 5IZ2A 2FENA 4WNLA 2K3OA 4CEHA 3GTKA 5M0JA 2LYIA 3EZAA 4APBA 2EZBA 1EB4A 4QIWA 2N1DB 4NLEA 2MP0A 1HY0A 2FUSA 1HQMD 4C5UA 1XL8A 5EYTA 2FELA 2A6HD 4ADMA 2PTQA 4CQ5A 2E2HA 3FKIA 3E04A 3CRW1 4FLCA 2LPJA 3EZEA 5F91A 2NVXA 1YNND 3GZHA 4NSLA 2NVYA 5D6BA 3GTOA 2RJSA 1TJVA 2O5JD 1EZAA 1SFOA 1I0AA 2OHYA 1C3CA 3RD8A 2R7ZA 3NZ4A 1I3QA 3LRDA 3GTDA 1R9TA 1B8FA 1GK3A 1VDKA 1XMDA 2AQLA 2EZAA 1FURA 1Y1VA 3R6YA 3GTJA 1I6VD 2FIPA 2RJRA 2NYFA 3GTLA 3OCEA 4FBSA 2LKMB 1YNJD 2HROA 2O7FA 2VK9A 2F5JA 3GTQA 2PFMA 4MX2A 1KQ7A 1XWOA 2R92A 2K3QA 3UNVA 2VL7A 1T6PA 2B63A 1W27A 2YIIA 3GTPA 2A68D 5F92A 1K62A 4CEIA 1FUQA 1TJUA 2E2IA 2MQAA 1Q5NA 4C5RA 3GTMA 3C8TA 1TWHA 2K3NA 2R93A 1C3UA 1K7WA 1U16A 2HWGA 3U44A 3CRVA 4A15A 5H8WA 1TWCA 4BABA 2LPIA 2HVGA 2O6YA 2JA7A 1K83A 3OCFA 1GKMA 2PTRA 2VUMA 5HW2A 1FUOA 1U15A 3LR8A 1FUPA 3TV2A 1J3UA 2E9FA 1TWGA 3R6VA 2Y0NA 2JA5A 3LR2A 2VD6A 3CZOA 4EEIA 2EZCA 2QVEA 2O7BA 2A6ED 2J91A 1Y1WA 4FFXA 1DOFA 1Y2MA 4CEJA 3H0GA 1TJWA 3LR6A 1I50A 2JA6A 1GKJA 3R6QA 2FIOA 4C6GA 5M0IA 1ZYMA 2MX9A 1YFEA 1EZBA 1DCNA 1TJ7A 3GTGA 3RRPA 1GK2A 2O7DA 2CW0D 1T6JA 4BAAA 1IW7D 1TWFA
chains in the Genus database with same CATH topology
4APAA 2NYNA 1RE5A 1JSWA 4ADLA 3BHGA 2X75A 2PTSA 4V2QA 1AUWA 2QGAB 4C5SA 1YISA 3KDZA 1HY1A 5EYVA 3NO9A 4EFCA 2O78A 2O7EA 4V2RA 4HGVA 3KDYA 1YFMA 3QBPA 4APBA 1EB4A 4NLEA 1HY0A 2FUSA 4C5UA 4ADMA 2PTQA 4CQ5A 3E04A 4FLCA 5F91A 3GZHA 4NSLA 5D6BA 2RJSA 1TJVA 1I0AA 2OHYA 1C3CA 3RD8A 3NZ4A 3GTDA 1GK3A 1B8FA 1VDKA 1FURA 3R6YA 3OCEA 2RJRA 2NYFA 2O7FA 2PFMA 4MX2A 1KQ7A 1XWOA 3UNVA 1T6PA 1W27A 2YIIA 5F92A 1K62A 1FUQA 1TJUA 1Q5NA 4C5RA 3C8TA 1C3UA 1K7WA 1U16A 4BABA 2O6YA 2HVGA 3OCFA 1GKMA 2PTRA 5HW2A 1FUOA 1U15A 1FUPA 3TV2A 1J3UA 2E9FA 3R6VA 2VD6A 3CZOA 4EEIA 2QVEA 2O7BA 2J91A 4FFXA 1DOFA 1Y2MA 1TJWA 1GKJA 3R6QA 4C6GA 1YFEA 1DCNA 1TJ7A 3RRPA 1GK2A 2O7DA 1T6JA 4BAAA 5EYTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4APA A;  2NYN A;  1RE5 A;  1JSW A;  4ADL A;  3BHG A;  2X75 A;  2PTS A;  4V2Q A;  1AUW A;  2QGA B;  4C5S A;  1YIS A;  3KDZ A;  1HY1 A;  5EYV A;  3NO9 A;  4EFC A;  2O78 A;  2O7E A;  4V2R A;  4HGV A;  3KDY A;  1YFM A;  3QBP A;  4APB A;  1EB4 A;  4NLE A;  1HY0 A;  2FUS A;  4C5U A;  4ADM A;  2PTQ A;  4CQ5 A;  3E04 A;  4FLC A;  5F91 A;  3GZH A;  4NSL A;  5D6B A;  2RJS A;  1TJV A;  1I0A A;  2OHY A;  1C3C A;  3RD8 A;  3NZ4 A;  3GTD A;  1GK3 A;  1B8F A;  1VDK A;  1FUR A;  3R6Y A;  3OCE A;  2RJR A;  2NYF A;  2O7F A;  2PFM A;  4MX2 A;  1KQ7 A;  1XWO A;  3UNV A;  1T6P A;  1W27 A;  2YII A;  5F92 A;  1K62 A;  1FUQ A;  1TJU A;  1Q5N A;  4C5R A;  3C8T A;  1C3U A;  1K7W A;  1U16 A;  4BAB A;  2O6Y A;  2HVG A;  3OCF A;  1GKM A;  2PTR A;  5HW2 A;  1FUO A;  1U15 A;  1FUP A;  3TV2 A;  1J3U A;  2E9F A;  3R6V A;  2VD6 A;  3CZO A;  4EEI A;  2QVE A;  2O7B A;  2J91 A;  4FFX A;  1DOF A;  1Y2M A;  1TJW A;  1GKJ A;  3R6Q A;  4C6G A;  1YFE A;  1DCN A;  1TJ7 A;  3RRP A;  1GK2 A;  2O7D A;  1T6J A;  4BAA A;  5EYT A; 
#chains in the Genus database with same CATH topology
 4APA A;  2NYN A;  2BE5 D;  1RE5 A;  1JSW A;  4ADL A;  3BHG A;  1WCM A;  2X75 A;  2PTS A;  1ZYR D;  1XMC A;  1TWA A;  4V2Q A;  2YU9 A;  4C2M A;  1SMY D;  3CQZ A;  1AUW A;  1XL7 A;  2QGA B;  4C5S A;  1XLY A;  2MX8 A;  2N3E A;  1YIS A;  3KDZ A;  1HY1 A;  5EYV A;  3NO9 A;  4EFC A;  3EZB A;  2O78 A;  2O7E A;  2X0O A;  2X0Q A;  2VSF A;  2LTH A;  4V2R A;  4HGV A;  2A69 D;  3KDY A;  1YFM A;  2X0P A;  3QBP A;  3U4Q A;  5IZ2 A;  2FEN A;  4WNL A;  2K3O A;  4CEH A;  3GTK A;  5M0J A;  2LYI A;  3EZA A;  4APB A;  2EZB A;  1EB4 A;  4QIW A;  2N1D B;  4NLE A;  2MP0 A;  1HY0 A;  2FUS A;  1HQM D;  4C5U A;  1XL8 A;  5EYT A;  2FEL A;  2A6H D;  4ADM A;  2PTQ A;  4CQ5 A;  2E2H A;  3FKI A;  3E04 A;  3CRW 1;  4FLC A;  2LPJ A;  3EZE A;  5F91 A;  2NVX A;  1YNN D;  3GZH A;  4NSL A;  2NVY A;  5D6B A;  3GTO A;  2RJS A;  1TJV A;  2O5J D;  1EZA A;  1SFO A;  1I0A A;  2OHY A;  1C3C A;  3RD8 A;  2R7Z A;  3NZ4 A;  1I3Q A;  3LRD A;  3GTD A;  1R9T A;  1B8F A;  1GK3 A;  1VDK A;  1XMD A;  2AQL A;  2EZA A;  1FUR A;  1Y1V A;  3R6Y A;  3GTJ A;  1I6V D;  2FIP A;  2RJR A;  2NYF A;  3GTL A;  3OCE A;  4FBS A;  2LKM B;  1YNJ D;  2HRO A;  2O7F A;  2VK9 A;  2F5J A;  3GTQ A;  2PFM A;  4MX2 A;  1KQ7 A;  1XWO A;  2R92 A;  2K3Q A;  3UNV A;  2VL7 A;  1T6P A;  2B63 A;  1W27 A;  2YII A;  3GTP A;  2A68 D;  5F92 A;  1K62 A;  4CEI A;  1FUQ A;  1TJU A;  2E2I A;  2MQA A;  1Q5N A;  4C5R A;  3GTM A;  3C8T A;  1TWH A;  2K3N A;  2R93 A;  1C3U A;  1K7W A;  1U16 A;  2HWG A;  3U44 A;  3CRV A;  4A15 A;  5H8W A;  1TWC A;  4BAB A;  2LPI A;  2HVG A;  2O6Y A;  2JA7 A;  1K83 A;  3OCF A;  1GKM A;  2PTR A;  2VUM A;  5HW2 A;  1FUO A;  1U15 A;  3LR8 A;  1FUP A;  3TV2 A;  1J3U A;  2E9F A;  1TWG A;  3R6V A;  2Y0N A;  2JA5 A;  3LR2 A;  2VD6 A;  3CZO A;  4EEI A;  2EZC A;  2QVE A;  2O7B A;  2A6E D;  2J91 A;  1Y1W A;  4FFX A;  1DOF A;  1Y2M A;  4CEJ A;  3H0G A;  1TJW A;  3LR6 A;  1I50 A;  2JA6 A;  1GKJ A;  3R6Q A;  2FIO A;  4C6G A;  5M0I A;  1ZYM A;  2MX9 A;  1YFE A;  1EZB A;  1DCN A;  1TJ7 A;  3GTG A;  3RRP A;  1GK2 A;  2O7D A;  2CW0 D;  1T6J A;  4BAA A;  1IW7 D;  1TWF A; 
#chains in the Genus database with same CATH homology
 4APA A;  2NYN A;  1RE5 A;  1JSW A;  4ADL A;  3BHG A;  2X75 A;  2PTS A;  4V2Q A;  1AUW A;  2QGA B;  4C5S A;  1YIS A;  3KDZ A;  1HY1 A;  5EYV A;  3NO9 A;  4EFC A;  2O78 A;  2O7E A;  4V2R A;  4HGV A;  3KDY A;  1YFM A;  3QBP A;  4APB A;  1EB4 A;  4NLE A;  1HY0 A;  2FUS A;  4C5U A;  4ADM A;  2PTQ A;  4CQ5 A;  3E04 A;  4FLC A;  5F91 A;  3GZH A;  4NSL A;  5D6B A;  2RJS A;  1TJV A;  1I0A A;  2OHY A;  1C3C A;  3RD8 A;  3NZ4 A;  3GTD A;  1GK3 A;  1B8F A;  1VDK A;  1FUR A;  3R6Y A;  3OCE A;  2RJR A;  2NYF A;  2O7F A;  2PFM A;  4MX2 A;  1KQ7 A;  1XWO A;  3UNV A;  1T6P A;  1W27 A;  2YII A;  5F92 A;  1K62 A;  1FUQ A;  1TJU A;  1Q5N A;  4C5R A;  3C8T A;  1C3U A;  1K7W A;  1U16 A;  4BAB A;  2O6Y A;  2HVG A;  3OCF A;  1GKM A;  2PTR A;  5HW2 A;  1FUO A;  1U15 A;  1FUP A;  3TV2 A;  1J3U A;  2E9F A;  3R6V A;  2VD6 A;  3CZO A;  4EEI A;  2QVE A;  2O7B A;  2J91 A;  4FFX A;  1DOF A;  1Y2M A;  1TJW A;  1GKJ A;  3R6Q A;  4C6G A;  1YFE A;  1DCN A;  1TJ7 A;  3RRP A;  1GK2 A;  2O7D A;  1T6J A;  4BAA A;  5EYT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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