4C5SA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 267
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
267
sequence length
667
structure length
638
Chain Sequence
b'SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIAGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHTDTLVDRLAEFEKRLSDRLENEMTAVRVLYEVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMMONIA-LYASE
publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 267
structure length 638
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c5sA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c5sA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c5sA02
1GKJA 1EB4A 2O7EA 3QBPA 2QVEA 3RD8A 3TV2A 4BABA 1AUWA 4C6GA 4MX2A 2PFMA 2O7DA 1C3CA 2X75A 2FUSA 3R6QA 2PTSA 3C8TA 2VD6A 4APBA 3E04A 5D6BA 3CZOA 1U15A 4V2QA 2HVGA 1C3UA 1W27A 3GTDA 5EYVA 4ADMA 1U16A 1RE5A 3GZHA 4EEIA 2PTQA 2PTRA 4C5SA 4CQ5A 3OCEA 1T6PA 4C5UA 2E9FA 1J3UA 1GKMA 2NYNA 3RRPA 1FURA 4FLCA 1B8FA 1YFMA 4HGVA 1DOFA 4APAA 1TJVA 1T6JA 2QGAB 1K62A 4V2RA 1FUPA 5F92A 1GK2A 1TJWA 3KDYA 1YISA 1XWOA 1FUQA 4NSLA 1I0AA 1TJ7A 1K7WA 1DCNA 1Q5NA 2NYFA 2YIIA 5F91A 1GK3A 1FUOA 3OCFA 3NZ4A 2O7FA 3KDZA 1JSWA 2RJSA 4BAAA 1KQ7A 2O7BA 3UNVA 4ADLA 3R6YA 2J91A 1Y2MA 4FFXA 4EFCA 3R6VA 2OHYA 1YFEA 1VDKA 4C5RA 2RJRA 5EYTA 5HW2A 1HY1A 1HY0A 3BHGA 3NO9A 2O6YA 2O78A 4NLEA 1TJUA
chains in the Genus database with same CATH superfamily
3GTGA 1GKJA 1EB4A 2O7EA 4C2MA 3QBPA 3LRDA 2QVEA 3RD8A 3TV2A 2VK9A 4BABA 1YNND 1AUWA 4CEIA 3LR8A 4C6GA 2X0QA 3GTQA 2FENA 3GTMA 2N3EA 4MX2A 2PFMA 2O7DA 1C3CA 2X75A 2FUSA 3GTLA 3CRW1 2Y0NA 3R6QA 2R93A 1I6VD 3GTPA 2PTSA 3C8TA 3U44A 2VD6A 4APBA 3E04A 5D6BA 2A68D 1U15A 2FIOA 4V2QA 3CZOA 2HVGA 1C3UA 1W27A 3GTDA 5EYVA 2FELA 2A6HD 4ADMA 1U16A 1RE5A 1TWFA 2A6ED 3FKIA 3GZHA 4EEIA 2PTQA 3CQZA 2LYIA 2N1DB 2LPJA 4C5SA 4CQ5A 2LTHA 1XMDA 2PTRA 3OCEA 1XL7A 1T6PA 1WCMA 4CEJA 2AQLA 2A69D 4C5UA 2E9FA 1J3UA 1TWCA 3EZEA 2E2IA 2R92A 1GKMA 2NYNA 1HQMD 3U4QA 3RRPA 3EZAA 1SFOA 1FURA 5H8WA 4FLCA 1Y1VA 1B8FA 1YFMA 4HGVA 1DOFA 1K83A 2VUMA 4APAA 1TJVA 1T6JA 2HWGA 2O5JD 4FBSA 5IZ2A 1EZBA 2BE5D 3EZBA 3CRVA 1I3QA 2QGAB 1K62A 4V2RA 4CEHA 1FUPA 4QIWA 5F92A 2X0OA 2E2HA 2FIPA 1GK2A 1TJWA 4WNLA 1Y1WA 3KDYA 2LPIA 1TWHA 1SMYD 2YU9A 1XWOA 1YISA 1FUQA 4NSLA 1I0AA 1TJ7A 3LR6A 2K3OA 1K7WA 1DCNA 1Q5NA 2NYFA 2YIIA 2NVYA 5F91A 3LR2A 2EZBA 1GK3A 1FUOA 3OCFA 3NZ4A 2B63A 1YNJD 2O7FA 1R9TA 3KDZA 2MX9A 4A15A 3GTJA 2NVXA 1JSWA 1EZAA 2R7ZA 2RJSA 4BAAA 1KQ7A 5M0JA 2O7BA 3UNVA 3GTKA 1ZYMA 3H0GA 4ADLA 3GTOA 2K3NA 3R6YA 1TWGA 2EZAA 2J91A 1Y2MA 4FFXA 4EFCA 2JA6A 3R6VA 2MX8A 1YFEA 1VDKA 2OHYA 4C5RA 2MQAA 1TWAA 2MP0A 5M0IA 2HROA 2VL7A 1XL8A 2RJRA 5EYTA 1ZYRD 5HW2A 1HY1A 2JA7A 1I50A 1IW7D 1XLYA 1HY0A 2EZCA 3BHGA 3NO9A 2O6YA 2VSFA 1XMCA 2LKMB 2O78A 4NLEA 2F5JA 2K3QA 2CW0D 2JA5A 1TJUA 2X0PA
chains in the Genus database with same CATH topology
1GKJA 1EB4A 2O7EA 3QBPA 2QVEA 3RD8A 3TV2A 4BABA 1AUWA 4C6GA 4MX2A 2PFMA 2O7DA 1C3CA 2X75A 2FUSA 3R6QA 2PTSA 3C8TA 2VD6A 4APBA 3E04A 5D6BA 3CZOA 1U15A 4V2QA 2HVGA 1C3UA 1W27A 3GTDA 5EYVA 4ADMA 1U16A 1RE5A 3GZHA 4EEIA 2PTQA 2PTRA 4C5SA 4CQ5A 3OCEA 1T6PA 4C5UA 2E9FA 1J3UA 1GKMA 2NYNA 3RRPA 1FURA 4FLCA 1B8FA 1YFMA 4HGVA 1DOFA 4APAA 1TJVA 1T6JA 2QGAB 1K62A 4V2RA 1FUPA 5F92A 1GK2A 1TJWA 3KDYA 1YISA 1XWOA 1FUQA 4NSLA 1I0AA 1TJ7A 1K7WA 1DCNA 1Q5NA 2NYFA 2YIIA 5F91A 1GK3A 1FUOA 3OCFA 3NZ4A 2O7FA 3KDZA 1JSWA 2RJSA 4BAAA 1KQ7A 2O7BA 3UNVA 4ADLA 3R6YA 2J91A 1Y2MA 4FFXA 4EFCA 3R6VA 2OHYA 1YFEA 1VDKA 4C5RA 2RJRA 5EYTA 5HW2A 1HY1A 1HY0A 3BHGA 3NO9A 2O6YA 2O78A 4NLEA 1TJUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1GKJ A;  1EB4 A;  2O7E A;  3QBP A;  2QVE A;  3RD8 A;  3TV2 A;  4BAB A;  1AUW A;  4C6G A;  4MX2 A;  2PFM A;  2O7D A;  1C3C A;  2X75 A;  2FUS A;  3R6Q A;  2PTS A;  3C8T A;  2VD6 A;  4APB A;  3E04 A;  5D6B A;  3CZO A;  1U15 A;  4V2Q A;  2HVG A;  1C3U A;  1W27 A;  3GTD A;  5EYV A;  4ADM A;  1U16 A;  1RE5 A;  3GZH A;  4EEI A;  2PTQ A;  2PTR A;  4C5S A;  4CQ5 A;  3OCE A;  1T6P A;  4C5U A;  2E9F A;  1J3U A;  1GKM A;  2NYN A;  3RRP A;  1FUR A;  4FLC A;  1B8F A;  1YFM A;  4HGV A;  1DOF A;  4APA A;  1TJV A;  1T6J A;  2QGA B;  1K62 A;  4V2R A;  1FUP A;  5F92 A;  1GK2 A;  1TJW A;  3KDY A;  1YIS A;  1XWO A;  1FUQ A;  4NSL A;  1I0A A;  1TJ7 A;  1K7W A;  1DCN A;  1Q5N A;  2NYF A;  2YII A;  5F91 A;  1GK3 A;  1FUO A;  3OCF A;  3NZ4 A;  2O7F A;  3KDZ A;  1JSW A;  2RJS A;  4BAA A;  1KQ7 A;  2O7B A;  3UNV A;  4ADL A;  3R6Y A;  2J91 A;  1Y2M A;  4FFX A;  4EFC A;  3R6V A;  2OHY A;  1YFE A;  1VDK A;  4C5R A;  2RJR A;  5EYT A;  5HW2 A;  1HY1 A;  1HY0 A;  3BHG A;  3NO9 A;  2O6Y A;  2O78 A;  4NLE A;  1TJU A; 
#chains in the Genus database with same CATH topology
 3GTG A;  1GKJ A;  1EB4 A;  2O7E A;  4C2M A;  3QBP A;  3LRD A;  2QVE A;  3RD8 A;  3TV2 A;  2VK9 A;  4BAB A;  1YNN D;  1AUW A;  4CEI A;  3LR8 A;  4C6G A;  2X0Q A;  3GTQ A;  2FEN A;  3GTM A;  2N3E A;  4MX2 A;  2PFM A;  2O7D A;  1C3C A;  2X75 A;  2FUS A;  3GTL A;  3CRW 1;  2Y0N A;  3R6Q A;  2R93 A;  1I6V D;  3GTP A;  2PTS A;  3C8T A;  3U44 A;  2VD6 A;  4APB A;  3E04 A;  5D6B A;  2A68 D;  1U15 A;  2FIO A;  4V2Q A;  3CZO A;  2HVG A;  1C3U A;  1W27 A;  3GTD A;  5EYV A;  2FEL A;  2A6H D;  4ADM A;  1U16 A;  1RE5 A;  1TWF A;  2A6E D;  3FKI A;  3GZH A;  4EEI A;  2PTQ A;  3CQZ A;  2LYI A;  2N1D B;  2LPJ A;  4C5S A;  4CQ5 A;  2LTH A;  1XMD A;  2PTR A;  3OCE A;  1XL7 A;  1T6P A;  1WCM A;  4CEJ A;  2AQL A;  2A69 D;  4C5U A;  2E9F A;  1J3U A;  1TWC A;  3EZE A;  2E2I A;  2R92 A;  1GKM A;  2NYN A;  1HQM D;  3U4Q A;  3RRP A;  3EZA A;  1SFO A;  1FUR A;  5H8W A;  4FLC A;  1Y1V A;  1B8F A;  1YFM A;  4HGV A;  1DOF A;  1K83 A;  2VUM A;  4APA A;  1TJV A;  1T6J A;  2HWG A;  2O5J D;  4FBS A;  5IZ2 A;  1EZB A;  2BE5 D;  3EZB A;  3CRV A;  1I3Q A;  2QGA B;  1K62 A;  4V2R A;  4CEH A;  1FUP A;  4QIW A;  5F92 A;  2X0O A;  2E2H A;  2FIP A;  1GK2 A;  1TJW A;  4WNL A;  1Y1W A;  3KDY A;  2LPI A;  1TWH A;  1SMY D;  2YU9 A;  1XWO A;  1YIS A;  1FUQ A;  4NSL A;  1I0A A;  1TJ7 A;  3LR6 A;  2K3O A;  1K7W A;  1DCN A;  1Q5N A;  2NYF A;  2YII A;  2NVY A;  5F91 A;  3LR2 A;  2EZB A;  1GK3 A;  1FUO A;  3OCF A;  3NZ4 A;  2B63 A;  1YNJ D;  2O7F A;  1R9T A;  3KDZ A;  2MX9 A;  4A15 A;  3GTJ A;  2NVX A;  1JSW A;  1EZA A;  2R7Z A;  2RJS A;  4BAA A;  1KQ7 A;  5M0J A;  2O7B A;  3UNV A;  3GTK A;  1ZYM A;  3H0G A;  4ADL A;  3GTO A;  2K3N A;  3R6Y A;  1TWG A;  2EZA A;  2J91 A;  1Y2M A;  4FFX A;  4EFC A;  2JA6 A;  3R6V A;  2MX8 A;  1YFE A;  1VDK A;  2OHY A;  4C5R A;  2MQA A;  1TWA A;  2MP0 A;  5M0I A;  2HRO A;  2VL7 A;  1XL8 A;  2RJR A;  5EYT A;  1ZYR D;  5HW2 A;  1HY1 A;  2JA7 A;  1I50 A;  1IW7 D;  1XLY A;  1HY0 A;  2EZC A;  3BHG A;  3NO9 A;  2O6Y A;  2VSF A;  1XMC A;  2LKM B;  2O78 A;  4NLE A;  2F5J A;  2K3Q A;  2CW0 D;  2JA5 A;  1TJU A;  2X0P A; 
#chains in the Genus database with same CATH homology
 1GKJ A;  1EB4 A;  2O7E A;  3QBP A;  2QVE A;  3RD8 A;  3TV2 A;  4BAB A;  1AUW A;  4C6G A;  4MX2 A;  2PFM A;  2O7D A;  1C3C A;  2X75 A;  2FUS A;  3R6Q A;  2PTS A;  3C8T A;  2VD6 A;  4APB A;  3E04 A;  5D6B A;  3CZO A;  1U15 A;  4V2Q A;  2HVG A;  1C3U A;  1W27 A;  3GTD A;  5EYV A;  4ADM A;  1U16 A;  1RE5 A;  3GZH A;  4EEI A;  2PTQ A;  2PTR A;  4C5S A;  4CQ5 A;  3OCE A;  1T6P A;  4C5U A;  2E9F A;  1J3U A;  1GKM A;  2NYN A;  3RRP A;  1FUR A;  4FLC A;  1B8F A;  1YFM A;  4HGV A;  1DOF A;  4APA A;  1TJV A;  1T6J A;  2QGA B;  1K62 A;  4V2R A;  1FUP A;  5F92 A;  1GK2 A;  1TJW A;  3KDY A;  1YIS A;  1XWO A;  1FUQ A;  4NSL A;  1I0A A;  1TJ7 A;  1K7W A;  1DCN A;  1Q5N A;  2NYF A;  2YII A;  5F91 A;  1GK3 A;  1FUO A;  3OCF A;  3NZ4 A;  2O7F A;  3KDZ A;  1JSW A;  2RJS A;  4BAA A;  1KQ7 A;  2O7B A;  3UNV A;  4ADL A;  3R6Y A;  2J91 A;  1Y2M A;  4FFX A;  4EFC A;  3R6V A;  2OHY A;  1YFE A;  1VDK A;  4C5R A;  2RJR A;  5EYT A;  5HW2 A;  1HY1 A;  1HY0 A;  3BHG A;  3NO9 A;  2O6Y A;  2O78 A;  4NLE A;  1TJU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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