4C5SA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 267
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
267
sequence length
667
structure length
638
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIAGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHTDTLVDRLAEFEKRLSDRLENEMTAVRVLYEVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE
total genus 267
structure length 638
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c5sA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c5sA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c5sA02
4C6GA 1FURA 1J3UA 1U16A 5D6BA 3GZHA 3QBPA 1HY1A 1KQ7A 5F91A 4V2QA 1TJ7A 3TV2A 3R6YA 4ADMA 4BABA 1YISA 2O78A 2PTQA 2RJSA 1GK3A 1AUWA 2X75A 2OHYA 1I0AA 3CZOA 1FUQA 2O7EA 1GKJA 1YFMA 1W27A 2NYFA 1XWOA 4V2RA 4C5RA 4NSLA 2PTSA 3KDZA 4CQ5A 3OCFA 3RD8A 3R6QA 2HVGA 3C8TA 3NZ4A 2VD6A 2O7BA 1Y2MA 1EB4A 4EFCA 1JSWA 4APAA 3KDYA 4C5UA 4FLCA 1T6JA 5HW2A 1GKMA 2J91A 2NYNA 2O7FA 2O7DA 3NO9A 1GK2A 4BAAA 1K7WA 2E9FA 4NLEA 3UNVA 4HGVA 1DOFA 1K62A 3R6VA 2O6YA 4FFXA 4EEIA 4APBA 3RRPA 1U15A 1HY0A 2QGAB 1C3CA 3BHGA 5EYVA 1FUPA 5EYTA 2YIIA 1B8FA 1DCNA 1C3UA 1TJWA 1FUOA 2PFMA 3GTDA 1T6PA 2FUSA 5F92A 2RJRA 4ADLA 1VDKA 4MX2A 3OCEA 1RE5A 2QVEA 4C5SA 1Q5NA 3E04A 1TJVA 2PTRA 1YFEA 1TJUA
chains in the Genus database with same CATH superfamily
4C6GA 3GTOA 1FURA 1J3UA 1U16A 2FELA 2N1DB 5D6BA 5H8WA 2N3EA 1XL7A 2HROA 3GZHA 3QBPA 1HY1A 1KQ7A 3GTMA 4QIWA 5F91A 4V2QA 1TJ7A 3TV2A 3R6YA 4ADMA 4BABA 1YISA 2O78A 2PTQA 2K3QA 1XMDA 2LYIA 3LR8A 2K3OA 1EZBA 2E2HA 1GK3A 2RJSA 4A15A 1YNJD 1Y1WA 1AUWA 3LR6A 2X75A 1TWHA 3GTPA 2R92A 2OHYA 1I0AA 1R9TA 3CZOA 2CW0D 4CEIA 1FUQA 2O7EA 3GTLA 1GKJA 1YFMA 2A6ED 1W27A 2NYFA 1XWOA 3LRDA 5M0JA 2JA7A 2K3NA 4V2RA 3H0GA 2FIOA 4C5RA 3FKIA 4NSLA 2PTSA 3KDZA 1TWCA 2A69D 4CQ5A 3OCFA 3RD8A 5M0IA 3R6QA 2HVGA 1Y1VA 1XL8A 2YU9A 2MX8A 3C8TA 2MQAA 3NZ4A 2X0QA 2VD6A 2O7BA 1Y2MA 1EB4A 4EFCA 2EZAA 1JSWA 4APAA 3GTKA 3KDYA 3LR2A 3U44A 4C5UA 4FLCA 3CQZA 1T6JA 2LTHA 2R7ZA 2JA6A 2B63A 2VK9A 5HW2A 1GKMA 1YNND 2J91A 2MP0A 2VUMA 1I50A 2LPJA 2EZBA 1I3QA 2NYNA 2O7FA 2JA5A 2O7DA 3NO9A 2VL7A 3EZBA 2X0OA 2X0PA 2A68D 3GTGA 1GK2A 4BAAA 1K7WA 2E9FA 5IZ2A 1EZAA 1ZYMA 4NLEA 2LKMB 4HGVA 1DOFA 3UNVA 1HQMD 2AQLA 1K62A 3CRVA 3R6VA 4CEHA 2O6YA 4FFXA 4EEIA 4APBA 3RRPA 1SMYD 1U15A 1XLYA 1HY0A 2QGAB 1C3CA 3BHGA 2HWGA 2MX9A 5EYVA 1FUPA 3EZEA 3GTQA 5EYTA 1TJUA 2YIIA 2O5JD 1B8FA 2NVYA 1WCMA 1K83A 2FIPA 3U4QA 2EZCA 2BE5D 1C3UA 1DCNA 1TJWA 1XMCA 1ZYRD 1FUOA 1IW7D 1I6VD 3GTJA 2PFMA 3GTDA 1T6PA 2FUSA 1TWGA 5F92A 2RJRA 2VSFA 4ADLA 2FENA 2Y0NA 1VDKA 3EZAA 4FBSA 4CEJA 4MX2A 2NVXA 1SFOA 2F5JA 3OCEA 1RE5A 4WNLA 2QVEA 4C5SA 1Q5NA 3E04A 1TWAA 1TWFA 2A6HD 2LPIA 1TJVA 2E2IA 2PTRA 1YFEA 4C2MA 3CRW1 2R93A
chains in the Genus database with same CATH topology
4C6GA 1FURA 1J3UA 1U16A 5D6BA 3GZHA 3QBPA 1HY1A 1KQ7A 5F91A 4V2QA 1TJ7A 3TV2A 3R6YA 4ADMA 4BABA 1YISA 2O78A 2PTQA 2RJSA 1GK3A 1AUWA 2X75A 2OHYA 1I0AA 3CZOA 1FUQA 2O7EA 1GKJA 1YFMA 1W27A 2NYFA 1XWOA 4V2RA 4C5RA 4NSLA 2PTSA 3KDZA 4CQ5A 3OCFA 3RD8A 3R6QA 2HVGA 3C8TA 3NZ4A 2VD6A 2O7BA 1Y2MA 1EB4A 4EFCA 1JSWA 4APAA 3KDYA 4C5UA 4FLCA 1T6JA 5HW2A 1GKMA 2J91A 2NYNA 2O7FA 2O7DA 3NO9A 1GK2A 4BAAA 1K7WA 2E9FA 4NLEA 3UNVA 4HGVA 1DOFA 1K62A 3R6VA 2O6YA 4FFXA 4EEIA 4APBA 3RRPA 1U15A 1HY0A 2QGAB 1C3CA 3BHGA 5EYVA 1FUPA 5EYTA 2YIIA 1B8FA 1DCNA 1C3UA 1TJWA 1FUOA 2PFMA 3GTDA 1T6PA 2FUSA 5F92A 2RJRA 4ADLA 1VDKA 4MX2A 3OCEA 1RE5A 2QVEA 4C5SA 1Q5NA 3E04A 1TJVA 2PTRA 1YFEA 1TJUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4C6G A;  1FUR A;  1J3U A;  1U16 A;  5D6B A;  3GZH A;  3QBP A;  1HY1 A;  1KQ7 A;  5F91 A;  4V2Q A;  1TJ7 A;  3TV2 A;  3R6Y A;  4ADM A;  4BAB A;  1YIS A;  2O78 A;  2PTQ A;  2RJS A;  1GK3 A;  1AUW A;  2X75 A;  2OHY A;  1I0A A;  3CZO A;  1FUQ A;  2O7E A;  1GKJ A;  1YFM A;  1W27 A;  2NYF A;  1XWO A;  4V2R A;  4C5R A;  4NSL A;  2PTS A;  3KDZ A;  4CQ5 A;  3OCF A;  3RD8 A;  3R6Q A;  2HVG A;  3C8T A;  3NZ4 A;  2VD6 A;  2O7B A;  1Y2M A;  1EB4 A;  4EFC A;  1JSW A;  4APA A;  3KDY A;  4C5U A;  4FLC A;  1T6J A;  5HW2 A;  1GKM A;  2J91 A;  2NYN A;  2O7F A;  2O7D A;  3NO9 A;  1GK2 A;  4BAA A;  1K7W A;  2E9F A;  4NLE A;  3UNV A;  4HGV A;  1DOF A;  1K62 A;  3R6V A;  2O6Y A;  4FFX A;  4EEI A;  4APB A;  3RRP A;  1U15 A;  1HY0 A;  2QGA B;  1C3C A;  3BHG A;  5EYV A;  1FUP A;  5EYT A;  2YII A;  1B8F A;  1DCN A;  1C3U A;  1TJW A;  1FUO A;  2PFM A;  3GTD A;  1T6P A;  2FUS A;  5F92 A;  2RJR A;  4ADL A;  1VDK A;  4MX2 A;  3OCE A;  1RE5 A;  2QVE A;  4C5S A;  1Q5N A;  3E04 A;  1TJV A;  2PTR A;  1YFE A;  1TJU A; 
#chains in the Genus database with same CATH topology
 4C6G A;  3GTO A;  1FUR A;  1J3U A;  1U16 A;  2FEL A;  2N1D B;  5D6B A;  5H8W A;  2N3E A;  1XL7 A;  2HRO A;  3GZH A;  3QBP A;  1HY1 A;  1KQ7 A;  3GTM A;  4QIW A;  5F91 A;  4V2Q A;  1TJ7 A;  3TV2 A;  3R6Y A;  4ADM A;  4BAB A;  1YIS A;  2O78 A;  2PTQ A;  2K3Q A;  1XMD A;  2LYI A;  3LR8 A;  2K3O A;  1EZB A;  2E2H A;  1GK3 A;  2RJS A;  4A15 A;  1YNJ D;  1Y1W A;  1AUW A;  3LR6 A;  2X75 A;  1TWH A;  3GTP A;  2R92 A;  2OHY A;  1I0A A;  1R9T A;  3CZO A;  2CW0 D;  4CEI A;  1FUQ A;  2O7E A;  3GTL A;  1GKJ A;  1YFM A;  2A6E D;  1W27 A;  2NYF A;  1XWO A;  3LRD A;  5M0J A;  2JA7 A;  2K3N A;  4V2R A;  3H0G A;  2FIO A;  4C5R A;  3FKI A;  4NSL A;  2PTS A;  3KDZ A;  1TWC A;  2A69 D;  4CQ5 A;  3OCF A;  3RD8 A;  5M0I A;  3R6Q A;  2HVG A;  1Y1V A;  1XL8 A;  2YU9 A;  2MX8 A;  3C8T A;  2MQA A;  3NZ4 A;  2X0Q A;  2VD6 A;  2O7B A;  1Y2M A;  1EB4 A;  4EFC A;  2EZA A;  1JSW A;  4APA A;  3GTK A;  3KDY A;  3LR2 A;  3U44 A;  4C5U A;  4FLC A;  3CQZ A;  1T6J A;  2LTH A;  2R7Z A;  2JA6 A;  2B63 A;  2VK9 A;  5HW2 A;  1GKM A;  1YNN D;  2J91 A;  2MP0 A;  2VUM A;  1I50 A;  2LPJ A;  2EZB A;  1I3Q A;  2NYN A;  2O7F A;  2JA5 A;  2O7D A;  3NO9 A;  2VL7 A;  3EZB A;  2X0O A;  2X0P A;  2A68 D;  3GTG A;  1GK2 A;  4BAA A;  1K7W A;  2E9F A;  5IZ2 A;  1EZA A;  1ZYM A;  4NLE A;  2LKM B;  4HGV A;  1DOF A;  3UNV A;  1HQM D;  2AQL A;  1K62 A;  3CRV A;  3R6V A;  4CEH A;  2O6Y A;  4FFX A;  4EEI A;  4APB A;  3RRP A;  1SMY D;  1U15 A;  1XLY A;  1HY0 A;  2QGA B;  1C3C A;  3BHG A;  2HWG A;  2MX9 A;  5EYV A;  1FUP A;  3EZE A;  3GTQ A;  5EYT A;  1TJU A;  2YII A;  2O5J D;  1B8F A;  2NVY A;  1WCM A;  1K83 A;  2FIP A;  3U4Q A;  2EZC A;  2BE5 D;  1C3U A;  1DCN A;  1TJW A;  1XMC A;  1ZYR D;  1FUO A;  1IW7 D;  1I6V D;  3GTJ A;  2PFM A;  3GTD A;  1T6P A;  2FUS A;  1TWG A;  5F92 A;  2RJR A;  2VSF A;  4ADL A;  2FEN A;  2Y0N A;  1VDK A;  3EZA A;  4FBS A;  4CEJ A;  4MX2 A;  2NVX A;  1SFO A;  2F5J A;  3OCE A;  1RE5 A;  4WNL A;  2QVE A;  4C5S A;  1Q5N A;  3E04 A;  1TWA A;  1TWF A;  2A6H D;  2LPI A;  1TJV A;  2E2I A;  2PTR A;  1YFE A;  4C2M A;  3CRW 1;  2R93 A; 
#chains in the Genus database with same CATH homology
 4C6G A;  1FUR A;  1J3U A;  1U16 A;  5D6B A;  3GZH A;  3QBP A;  1HY1 A;  1KQ7 A;  5F91 A;  4V2Q A;  1TJ7 A;  3TV2 A;  3R6Y A;  4ADM A;  4BAB A;  1YIS A;  2O78 A;  2PTQ A;  2RJS A;  1GK3 A;  1AUW A;  2X75 A;  2OHY A;  1I0A A;  3CZO A;  1FUQ A;  2O7E A;  1GKJ A;  1YFM A;  1W27 A;  2NYF A;  1XWO A;  4V2R A;  4C5R A;  4NSL A;  2PTS A;  3KDZ A;  4CQ5 A;  3OCF A;  3RD8 A;  3R6Q A;  2HVG A;  3C8T A;  3NZ4 A;  2VD6 A;  2O7B A;  1Y2M A;  1EB4 A;  4EFC A;  1JSW A;  4APA A;  3KDY A;  4C5U A;  4FLC A;  1T6J A;  5HW2 A;  1GKM A;  2J91 A;  2NYN A;  2O7F A;  2O7D A;  3NO9 A;  1GK2 A;  4BAA A;  1K7W A;  2E9F A;  4NLE A;  3UNV A;  4HGV A;  1DOF A;  1K62 A;  3R6V A;  2O6Y A;  4FFX A;  4EEI A;  4APB A;  3RRP A;  1U15 A;  1HY0 A;  2QGA B;  1C3C A;  3BHG A;  5EYV A;  1FUP A;  5EYT A;  2YII A;  1B8F A;  1DCN A;  1C3U A;  1TJW A;  1FUO A;  2PFM A;  3GTD A;  1T6P A;  2FUS A;  5F92 A;  2RJR A;  4ADL A;  1VDK A;  4MX2 A;  3OCE A;  1RE5 A;  2QVE A;  4C5S A;  1Q5N A;  3E04 A;  1TJV A;  2PTR A;  1YFE A;  1TJU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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