4C5SA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 267
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
267
sequence length
667
structure length
638
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIAGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHTDTLVDRLAEFEKRLSDRLENEMTAVRVLYEVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE
total genus 267
structure length 638
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c5sA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c5sA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c5sA02
3OCFA 1Y2MA 4C5UA 2YIIA 2PTSA 1RE5A 1YFMA 5HW2A 1FUPA 2O6YA 2RJSA 3BHGA 5D6BA 4V2QA 2QGAB 1I0AA 4APAA 2QVEA 1AUWA 4ADMA 3RD8A 1TJVA 1JSWA 1GK3A 4FLCA 1DOFA 4FFXA 1KQ7A 2OHYA 5F91A 2J91A 3KDZA 1C3UA 2HVGA 1FUQA 4HGVA 3NZ4A 1HY1A 5F92A 2O7BA 2NYNA 2O78A 1B8FA 4APBA 1C3CA 2PFMA 1J3UA 1TJ7A 2RJRA 3GTDA 4C5SA 1HY0A 1T6PA 1VDKA 2O7FA 4EEIA 1YISA 1GK2A 2O7EA 2X75A 3OCEA 1GKJA 1TJWA 3UNVA 4MX2A 3E04A 3RRPA 4ADLA 2E9FA 3NO9A 3R6VA 2FUSA 3CZOA 1YFEA 1U16A 1GKMA 4V2RA 4BABA 1FUOA 4BAAA 3TV2A 1W27A 4NLEA 2PTQA 3KDYA 4C5RA 4CQ5A 1Q5NA 4C6GA 2NYFA 1K62A 3R6YA 1T6JA 5EYVA 1FURA 1DCNA 1EB4A 3GZHA 3C8TA 3R6QA 1U15A 1TJUA 5EYTA 3QBPA 2PTRA 4NSLA 1K7WA 2O7DA 1XWOA 2VD6A 4EFCA
chains in the Genus database with same CATH superfamily
2YU9A 3OCFA 4A15A 1SFOA 1XMCA 2FELA 1Y2MA 4C5UA 2YIIA 3LR2A 1TWAA 2VL7A 2EZCA 4C2MA 2PTSA 1RE5A 3EZAA 2X0PA 3EZBA 3LR8A 1YFMA 5HW2A 2FIOA 1FUPA 2O6YA 3LR6A 2MP0A 2RJSA 1I6VD 3BHGA 3CRVA 5D6BA 4V2QA 2QGAB 1I0AA 3EZEA 4APAA 1XMDA 2QVEA 2N3EA 1AUWA 4ADMA 3RD8A 1TJVA 2EZBA 2K3QA 1JSWA 1IW7D 1GK3A 4FLCA 1DOFA 1TWCA 1K83A 4FFXA 2JA5A 1KQ7A 2OHYA 4QIWA 5F91A 2J91A 1YNJD 3KDZA 2LTHA 1C3UA 5IZ2A 2HVGA 2K3NA 1TWFA 4HGVA 4CEJA 3NZ4A 1HY1A 3GTOA 1TWGA 1YNND 5F92A 2R93A 2HROA 2MX9A 2O7BA 2NYNA 2O78A 3LRDA 1B8FA 4APBA 3GTKA 2LKMB 1ZYMA 2N1DB 1C3CA 2K3OA 2PFMA 1J3UA 1TJ7A 2JA7A 2RJRA 3GTDA 2VD6A 4C5SA 2VUMA 2LYIA 3H0GA 2R7ZA 3GTMA 2R92A 1HY0A 1T6PA 1EZAA 1VDKA 2LPJA 3FKIA 1EZBA 3CRW1 2A69D 5M0JA 2CW0D 2VSFA 3GTLA 2O7FA 2A68D 1HQMD 3U44A 4EEIA 1SMYD 1YISA 1GK2A 1ZYRD 3GTJA 1XL7A 2O7EA 2AQLA 2X75A 3OCEA 2NVXA 1GKJA 1TJWA 1TWHA 3UNVA 2JA6A 4MX2A 3E04A 3RRPA 2E9FA 4ADLA 2X0QA 3NO9A 2NVYA 4FBSA 3R6VA 2O5JD 2LPIA 2E2HA 1YFEA 2FUSA 3CZOA 2A6ED 2Y0NA 3GTQA 1U16A 2VK9A 1GKMA 2EZAA 1XL8A 1R9TA 2X0OA 4V2RA 4BABA 1FUOA 4BAAA 5M0IA 1XLYA 1I3QA 3TV2A 2A6HD 1W27A 4NLEA 3U4QA 2B63A 2PTQA 4CEHA 3KDYA 4C5RA 4CQ5A 1Q5NA 4C6GA 2NYFA 1K62A 3R6YA 1T6JA 5EYVA 5H8WA 1FURA 4CEIA 1DCNA 2E2IA 3GTPA 2F5JA 1EB4A 3GZHA 2FIPA 3C8TA 3R6QA 1Y1WA 1U15A 1I50A 2BE5D 3GTGA 4WNLA 2HWGA 1TJUA 5EYTA 3QBPA 2PTRA 4NSLA 1Y1VA 1K7WA 2FENA 3CQZA 2O7DA 1WCMA 1XWOA 1FUQA 4EFCA 2MQAA 2MX8A
chains in the Genus database with same CATH topology
3OCFA 1Y2MA 4C5UA 2YIIA 2PTSA 1RE5A 1YFMA 5HW2A 1FUPA 2O6YA 2RJSA 3BHGA 5D6BA 4V2QA 2QGAB 1I0AA 4APAA 2QVEA 1AUWA 4ADMA 3RD8A 1TJVA 1JSWA 1GK3A 4FLCA 1DOFA 4FFXA 1KQ7A 2OHYA 5F91A 2J91A 3KDZA 1C3UA 2HVGA 1FUQA 4HGVA 3NZ4A 1HY1A 5F92A 2O7BA 2NYNA 2O78A 1B8FA 4APBA 1C3CA 2PFMA 1J3UA 1TJ7A 2RJRA 3GTDA 4C5SA 1HY0A 1T6PA 1VDKA 2O7FA 4EEIA 1YISA 1GK2A 2O7EA 2X75A 3OCEA 1GKJA 1TJWA 3UNVA 4MX2A 3E04A 3RRPA 4ADLA 2E9FA 3NO9A 3R6VA 2FUSA 3CZOA 1YFEA 1U16A 1GKMA 4V2RA 4BABA 1FUOA 4BAAA 3TV2A 1W27A 4NLEA 2PTQA 3KDYA 4C5RA 4CQ5A 1Q5NA 4C6GA 2NYFA 1K62A 3R6YA 1T6JA 5EYVA 1FURA 1DCNA 1EB4A 3GZHA 3C8TA 3R6QA 1U15A 1TJUA 5EYTA 3QBPA 2PTRA 4NSLA 1K7WA 2O7DA 1XWOA 2VD6A 4EFCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3OCF A;  1Y2M A;  4C5U A;  2YII A;  2PTS A;  1RE5 A;  1YFM A;  5HW2 A;  1FUP A;  2O6Y A;  2RJS A;  3BHG A;  5D6B A;  4V2Q A;  2QGA B;  1I0A A;  4APA A;  2QVE A;  1AUW A;  4ADM A;  3RD8 A;  1TJV A;  1JSW A;  1GK3 A;  4FLC A;  1DOF A;  4FFX A;  1KQ7 A;  2OHY A;  5F91 A;  2J91 A;  3KDZ A;  1C3U A;  2HVG A;  1FUQ A;  4HGV A;  3NZ4 A;  1HY1 A;  5F92 A;  2O7B A;  2NYN A;  2O78 A;  1B8F A;  4APB A;  1C3C A;  2PFM A;  1J3U A;  1TJ7 A;  2RJR A;  3GTD A;  4C5S A;  1HY0 A;  1T6P A;  1VDK A;  2O7F A;  4EEI A;  1YIS A;  1GK2 A;  2O7E A;  2X75 A;  3OCE A;  1GKJ A;  1TJW A;  3UNV A;  4MX2 A;  3E04 A;  3RRP A;  4ADL A;  2E9F A;  3NO9 A;  3R6V A;  2FUS A;  3CZO A;  1YFE A;  1U16 A;  1GKM A;  4V2R A;  4BAB A;  1FUO A;  4BAA A;  3TV2 A;  1W27 A;  4NLE A;  2PTQ A;  3KDY A;  4C5R A;  4CQ5 A;  1Q5N A;  4C6G A;  2NYF A;  1K62 A;  3R6Y A;  1T6J A;  5EYV A;  1FUR A;  1DCN A;  1EB4 A;  3GZH A;  3C8T A;  3R6Q A;  1U15 A;  1TJU A;  5EYT A;  3QBP A;  2PTR A;  4NSL A;  1K7W A;  2O7D A;  1XWO A;  2VD6 A;  4EFC A; 
#chains in the Genus database with same CATH topology
 2YU9 A;  3OCF A;  4A15 A;  1SFO A;  1XMC A;  2FEL A;  1Y2M A;  4C5U A;  2YII A;  3LR2 A;  1TWA A;  2VL7 A;  2EZC A;  4C2M A;  2PTS A;  1RE5 A;  3EZA A;  2X0P A;  3EZB A;  3LR8 A;  1YFM A;  5HW2 A;  2FIO A;  1FUP A;  2O6Y A;  3LR6 A;  2MP0 A;  2RJS A;  1I6V D;  3BHG A;  3CRV A;  5D6B A;  4V2Q A;  2QGA B;  1I0A A;  3EZE A;  4APA A;  1XMD A;  2QVE A;  2N3E A;  1AUW A;  4ADM A;  3RD8 A;  1TJV A;  2EZB A;  2K3Q A;  1JSW A;  1IW7 D;  1GK3 A;  4FLC A;  1DOF A;  1TWC A;  1K83 A;  4FFX A;  2JA5 A;  1KQ7 A;  2OHY A;  4QIW A;  5F91 A;  2J91 A;  1YNJ D;  3KDZ A;  2LTH A;  1C3U A;  5IZ2 A;  2HVG A;  2K3N A;  1TWF A;  4HGV A;  4CEJ A;  3NZ4 A;  1HY1 A;  3GTO A;  1TWG A;  1YNN D;  5F92 A;  2R93 A;  2HRO A;  2MX9 A;  2O7B A;  2NYN A;  2O78 A;  3LRD A;  1B8F A;  4APB A;  3GTK A;  2LKM B;  1ZYM A;  2N1D B;  1C3C A;  2K3O A;  2PFM A;  1J3U A;  1TJ7 A;  2JA7 A;  2RJR A;  3GTD A;  2VD6 A;  4C5S A;  2VUM A;  2LYI A;  3H0G A;  2R7Z A;  3GTM A;  2R92 A;  1HY0 A;  1T6P A;  1EZA A;  1VDK A;  2LPJ A;  3FKI A;  1EZB A;  3CRW 1;  2A69 D;  5M0J A;  2CW0 D;  2VSF A;  3GTL A;  2O7F A;  2A68 D;  1HQM D;  3U44 A;  4EEI A;  1SMY D;  1YIS A;  1GK2 A;  1ZYR D;  3GTJ A;  1XL7 A;  2O7E A;  2AQL A;  2X75 A;  3OCE A;  2NVX A;  1GKJ A;  1TJW A;  1TWH A;  3UNV A;  2JA6 A;  4MX2 A;  3E04 A;  3RRP A;  2E9F A;  4ADL A;  2X0Q A;  3NO9 A;  2NVY A;  4FBS A;  3R6V A;  2O5J D;  2LPI A;  2E2H A;  1YFE A;  2FUS A;  3CZO A;  2A6E D;  2Y0N A;  3GTQ A;  1U16 A;  2VK9 A;  1GKM A;  2EZA A;  1XL8 A;  1R9T A;  2X0O A;  4V2R A;  4BAB A;  1FUO A;  4BAA A;  5M0I A;  1XLY A;  1I3Q A;  3TV2 A;  2A6H D;  1W27 A;  4NLE A;  3U4Q A;  2B63 A;  2PTQ A;  4CEH A;  3KDY A;  4C5R A;  4CQ5 A;  1Q5N A;  4C6G A;  2NYF A;  1K62 A;  3R6Y A;  1T6J A;  5EYV A;  5H8W A;  1FUR A;  4CEI A;  1DCN A;  2E2I A;  3GTP A;  2F5J A;  1EB4 A;  3GZH A;  2FIP A;  3C8T A;  3R6Q A;  1Y1W A;  1U15 A;  1I50 A;  2BE5 D;  3GTG A;  4WNL A;  2HWG A;  1TJU A;  5EYT A;  3QBP A;  2PTR A;  4NSL A;  1Y1V A;  1K7W A;  2FEN A;  3CQZ A;  2O7D A;  1WCM A;  1XWO A;  1FUQ A;  4EFC A;  2MQA A;  2MX8 A; 
#chains in the Genus database with same CATH homology
 3OCF A;  1Y2M A;  4C5U A;  2YII A;  2PTS A;  1RE5 A;  1YFM A;  5HW2 A;  1FUP A;  2O6Y A;  2RJS A;  3BHG A;  5D6B A;  4V2Q A;  2QGA B;  1I0A A;  4APA A;  2QVE A;  1AUW A;  4ADM A;  3RD8 A;  1TJV A;  1JSW A;  1GK3 A;  4FLC A;  1DOF A;  4FFX A;  1KQ7 A;  2OHY A;  5F91 A;  2J91 A;  3KDZ A;  1C3U A;  2HVG A;  1FUQ A;  4HGV A;  3NZ4 A;  1HY1 A;  5F92 A;  2O7B A;  2NYN A;  2O78 A;  1B8F A;  4APB A;  1C3C A;  2PFM A;  1J3U A;  1TJ7 A;  2RJR A;  3GTD A;  4C5S A;  1HY0 A;  1T6P A;  1VDK A;  2O7F A;  4EEI A;  1YIS A;  1GK2 A;  2O7E A;  2X75 A;  3OCE A;  1GKJ A;  1TJW A;  3UNV A;  4MX2 A;  3E04 A;  3RRP A;  4ADL A;  2E9F A;  3NO9 A;  3R6V A;  2FUS A;  3CZO A;  1YFE A;  1U16 A;  1GKM A;  4V2R A;  4BAB A;  1FUO A;  4BAA A;  3TV2 A;  1W27 A;  4NLE A;  2PTQ A;  3KDY A;  4C5R A;  4CQ5 A;  1Q5N A;  4C6G A;  2NYF A;  1K62 A;  3R6Y A;  1T6J A;  5EYV A;  1FUR A;  1DCN A;  1EB4 A;  3GZH A;  3C8T A;  3R6Q A;  1U15 A;  1TJU A;  5EYT A;  3QBP A;  2PTR A;  4NSL A;  1K7W A;  2O7D A;  1XWO A;  2VD6 A;  4EFC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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