4C5SA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 267
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
267
sequence length
667
structure length
638
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIAGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHTDTLVDRLAEFEKRLSDRLENEMTAVRVLYEVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE
publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
total genus 267
structure length 638
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c5sA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c5sA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c5sA02
3R6QA 2RJSA 4NSLA 1T6JA 2O7EA 3KDZA 2FUSA 1TJWA 1YFEA 2E9FA 1Y2MA 2HVGA 3NO9A 1DCNA 2X75A 4CQ5A 2O7BA 2QGAB 1EB4A 3E04A 4BABA 2O7FA 5HW2A 1KQ7A 4C6GA 5F92A 3RRPA 1U15A 2PFMA 2QVEA 4C5RA 4ADMA 2O6YA 1W27A 4APAA 1C3CA 4BAAA 4MX2A 1YISA 1K62A 3TV2A 3NZ4A 4C5UA 2NYNA 1GKJA 3UNVA 1FUPA 1TJUA 4V2RA 1AUWA 3C8TA 1YFMA 5D6BA 1K7WA 1JSWA 3GZHA 4C5SA 4FFXA 4APBA 3OCEA 1J3UA 1T6PA 4EEIA 4NLEA 2NYFA 2PTQA 1TJVA 4HGVA 1HY0A 4FLCA 1GK2A 3RD8A 4EFCA 1FURA 3R6VA 1DOFA 2J91A 1HY1A 2O78A 2O7DA 1TJ7A 3GTDA 1Q5NA 3OCFA 1C3UA 4ADLA 3KDYA 1GKMA 2RJRA 5EYTA 1B8FA 1VDKA 3CZOA 1GK3A 1RE5A 5F91A 1XWOA 4V2QA 3BHGA 1I0AA 5EYVA 3R6YA 2YIIA 2PTRA 1U16A 2OHYA 2PTSA 2VD6A 3QBPA 1FUQA 1FUOA
chains in the Genus database with same CATH superfamily
3R6QA 2X0OA 2RJSA 4NSLA 1T6JA 2O7EA 1XL8A 3KDZA 2FUSA 2R7ZA 3EZEA 1TJWA 1YFEA 2E9FA 1Y2MA 2EZAA 2HVGA 1YNJD 1SFOA 5IZ2A 3EZBA 1I3QA 3GTMA 3NO9A 1DCNA 4CEHA 2F5JA 2LPJA 3GTKA 2X75A 2EZBA 4CQ5A 2O7BA 2QGAB 2A69D 1EB4A 2NVYA 3E04A 4BABA 2O7FA 2LPIA 4WNLA 5HW2A 2FIOA 2LYIA 3GTQA 4C6GA 2NVXA 1WCMA 1KQ7A 5F92A 5H8WA 1Y1VA 1Y1WA 1U15A 3RRPA 2PFMA 2CW0D 2QVEA 2A6ED 4C5RA 2R93A 2E2IA 1R9TA 4ADMA 2O6YA 1W27A 4APAA 2HWGA 3CQZA 1XLYA 3GTLA 1C3CA 4BAAA 2JA6A 1XMDA 2X0PA 4MX2A 1YISA 1K62A 2N3EA 1TWAA 2VL7A 2LTHA 3TV2A 3NZ4A 3FKIA 4C5UA 1XL7A 2NYNA 2X0QA 1GKJA 2A6HD 1I6VD 3UNVA 1FUPA 2A68D 1TJUA 5M0JA 4V2RA 2JA5A 2JA7A 1AUWA 3U44A 3C8TA 1HQMD 2Y0NA 1YFMA 2EZCA 3LR2A 5D6BA 1XMCA 1K7WA 1JSWA 3GZHA 4C5SA 4FFXA 3H0GA 4APBA 2VUMA 3OCEA 1YNND 3LR6A 2MX8A 1J3UA 1T6PA 1ZYRD 4C2MA 4EEIA 1IW7D 4NLEA 3CRVA 2LKMB 2NYFA 2PTQA 3GTJA 1TJVA 4HGVA 2FIPA 1HY0A 3LR8A 4FLCA 1GK2A 4FBSA 2MQAA 2K3OA 1I50A 3RD8A 1EZBA 1EZAA 2O5JD 4EFCA 2MP0A 2K3QA 1FURA 1DOFA 2J91A 3R6VA 2YU9A 1HY1A 2O78A 2O7DA 2AQLA 1K83A 3GTPA 1TJ7A 3GTDA 1Q5NA 3GTGA 1ZYMA 3OCFA 2N1DB 3GTOA 3CRW1 1C3UA 3LRDA 4ADLA 4CEJA 1GKMA 2VSFA 4CEIA 3KDYA 2FENA 2RJRA 1TWFA 3U4QA 2E2HA 5EYTA 1TWGA 1B8FA 1VDKA 3EZAA 2BE5D 2MX9A 1GK3A 2K3NA 3CZOA 1RE5A 5F91A 1XWOA 4V2QA 1TWHA 2HROA 1SMYD 4QIWA 1I0AA 3BHGA 2B63A 2R92A 5EYVA 2VK9A 2YIIA 2PTRA 3R6YA 5M0IA 2FELA 4A15A 1U16A 2OHYA 2PTSA 2VD6A 3QBPA 1FUQA 1FUOA 1TWCA
chains in the Genus database with same CATH topology
3R6QA 2RJSA 4NSLA 1T6JA 2O7EA 3KDZA 2FUSA 1TJWA 1YFEA 2E9FA 1Y2MA 2HVGA 3NO9A 1DCNA 2X75A 4CQ5A 2O7BA 2QGAB 1EB4A 3E04A 4BABA 2O7FA 5HW2A 1KQ7A 4C6GA 5F92A 3RRPA 1U15A 2PFMA 2QVEA 4C5RA 4ADMA 2O6YA 1W27A 4APAA 1C3CA 4BAAA 4MX2A 1YISA 1K62A 3TV2A 3NZ4A 4C5UA 2NYNA 1GKJA 3UNVA 1FUPA 1TJUA 4V2RA 1AUWA 3C8TA 1YFMA 5D6BA 1K7WA 1JSWA 3GZHA 4C5SA 4FFXA 4APBA 3OCEA 1J3UA 1T6PA 4EEIA 4NLEA 2NYFA 2PTQA 1TJVA 4HGVA 1HY0A 4FLCA 1GK2A 3RD8A 4EFCA 1FURA 3R6VA 1DOFA 2J91A 1HY1A 2O78A 2O7DA 1TJ7A 3GTDA 1Q5NA 3OCFA 1C3UA 4ADLA 3KDYA 1GKMA 2RJRA 5EYTA 1B8FA 1VDKA 3CZOA 1GK3A 1RE5A 5F91A 1XWOA 4V2QA 3BHGA 1I0AA 5EYVA 3R6YA 2YIIA 2PTRA 1U16A 2OHYA 2PTSA 2VD6A 3QBPA 1FUQA 1FUOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3R6Q A;  2RJS A;  4NSL A;  1T6J A;  2O7E A;  3KDZ A;  2FUS A;  1TJW A;  1YFE A;  2E9F A;  1Y2M A;  2HVG A;  3NO9 A;  1DCN A;  2X75 A;  4CQ5 A;  2O7B A;  2QGA B;  1EB4 A;  3E04 A;  4BAB A;  2O7F A;  5HW2 A;  1KQ7 A;  4C6G A;  5F92 A;  3RRP A;  1U15 A;  2PFM A;  2QVE A;  4C5R A;  4ADM A;  2O6Y A;  1W27 A;  4APA A;  1C3C A;  4BAA A;  4MX2 A;  1YIS A;  1K62 A;  3TV2 A;  3NZ4 A;  4C5U A;  2NYN A;  1GKJ A;  3UNV A;  1FUP A;  1TJU A;  4V2R A;  1AUW A;  3C8T A;  1YFM A;  5D6B A;  1K7W A;  1JSW A;  3GZH A;  4C5S A;  4FFX A;  4APB A;  3OCE A;  1J3U A;  1T6P A;  4EEI A;  4NLE A;  2NYF A;  2PTQ A;  1TJV A;  4HGV A;  1HY0 A;  4FLC A;  1GK2 A;  3RD8 A;  4EFC A;  1FUR A;  3R6V A;  1DOF A;  2J91 A;  1HY1 A;  2O78 A;  2O7D A;  1TJ7 A;  3GTD A;  1Q5N A;  3OCF A;  1C3U A;  4ADL A;  3KDY A;  1GKM A;  2RJR A;  5EYT A;  1B8F A;  1VDK A;  3CZO A;  1GK3 A;  1RE5 A;  5F91 A;  1XWO A;  4V2Q A;  3BHG A;  1I0A A;  5EYV A;  3R6Y A;  2YII A;  2PTR A;  1U16 A;  2OHY A;  2PTS A;  2VD6 A;  3QBP A;  1FUQ A;  1FUO A; 
#chains in the Genus database with same CATH topology
 3R6Q A;  2X0O A;  2RJS A;  4NSL A;  1T6J A;  2O7E A;  1XL8 A;  3KDZ A;  2FUS A;  2R7Z A;  3EZE A;  1TJW A;  1YFE A;  2E9F A;  1Y2M A;  2EZA A;  2HVG A;  1YNJ D;  1SFO A;  5IZ2 A;  3EZB A;  1I3Q A;  3GTM A;  3NO9 A;  1DCN A;  4CEH A;  2F5J A;  2LPJ A;  3GTK A;  2X75 A;  2EZB A;  4CQ5 A;  2O7B A;  2QGA B;  2A69 D;  1EB4 A;  2NVY A;  3E04 A;  4BAB A;  2O7F A;  2LPI A;  4WNL A;  5HW2 A;  2FIO A;  2LYI A;  3GTQ A;  4C6G A;  2NVX A;  1WCM A;  1KQ7 A;  5F92 A;  5H8W A;  1Y1V A;  1Y1W A;  1U15 A;  3RRP A;  2PFM A;  2CW0 D;  2QVE A;  2A6E D;  4C5R A;  2R93 A;  2E2I A;  1R9T A;  4ADM A;  2O6Y A;  1W27 A;  4APA A;  2HWG A;  3CQZ A;  1XLY A;  3GTL A;  1C3C A;  4BAA A;  2JA6 A;  1XMD A;  2X0P A;  4MX2 A;  1YIS A;  1K62 A;  2N3E A;  1TWA A;  2VL7 A;  2LTH A;  3TV2 A;  3NZ4 A;  3FKI A;  4C5U A;  1XL7 A;  2NYN A;  2X0Q A;  1GKJ A;  2A6H D;  1I6V D;  3UNV A;  1FUP A;  2A68 D;  1TJU A;  5M0J A;  4V2R A;  2JA5 A;  2JA7 A;  1AUW A;  3U44 A;  3C8T A;  1HQM D;  2Y0N A;  1YFM A;  2EZC A;  3LR2 A;  5D6B A;  1XMC A;  1K7W A;  1JSW A;  3GZH A;  4C5S A;  4FFX A;  3H0G A;  4APB A;  2VUM A;  3OCE A;  1YNN D;  3LR6 A;  2MX8 A;  1J3U A;  1T6P A;  1ZYR D;  4C2M A;  4EEI A;  1IW7 D;  4NLE A;  3CRV A;  2LKM B;  2NYF A;  2PTQ A;  3GTJ A;  1TJV A;  4HGV A;  2FIP A;  1HY0 A;  3LR8 A;  4FLC A;  1GK2 A;  4FBS A;  2MQA A;  2K3O A;  1I50 A;  3RD8 A;  1EZB A;  1EZA A;  2O5J D;  4EFC A;  2MP0 A;  2K3Q A;  1FUR A;  1DOF A;  2J91 A;  3R6V A;  2YU9 A;  1HY1 A;  2O78 A;  2O7D A;  2AQL A;  1K83 A;  3GTP A;  1TJ7 A;  3GTD A;  1Q5N A;  3GTG A;  1ZYM A;  3OCF A;  2N1D B;  3GTO A;  3CRW 1;  1C3U A;  3LRD A;  4ADL A;  4CEJ A;  1GKM A;  2VSF A;  4CEI A;  3KDY A;  2FEN A;  2RJR A;  1TWF A;  3U4Q A;  2E2H A;  5EYT A;  1TWG A;  1B8F A;  1VDK A;  3EZA A;  2BE5 D;  2MX9 A;  1GK3 A;  2K3N A;  3CZO A;  1RE5 A;  5F91 A;  1XWO A;  4V2Q A;  1TWH A;  2HRO A;  1SMY D;  4QIW A;  1I0A A;  3BHG A;  2B63 A;  2R92 A;  5EYV A;  2VK9 A;  2YII A;  2PTR A;  3R6Y A;  5M0I A;  2FEL A;  4A15 A;  1U16 A;  2OHY A;  2PTS A;  2VD6 A;  3QBP A;  1FUQ A;  1FUO A;  1TWC A; 
#chains in the Genus database with same CATH homology
 3R6Q A;  2RJS A;  4NSL A;  1T6J A;  2O7E A;  3KDZ A;  2FUS A;  1TJW A;  1YFE A;  2E9F A;  1Y2M A;  2HVG A;  3NO9 A;  1DCN A;  2X75 A;  4CQ5 A;  2O7B A;  2QGA B;  1EB4 A;  3E04 A;  4BAB A;  2O7F A;  5HW2 A;  1KQ7 A;  4C6G A;  5F92 A;  3RRP A;  1U15 A;  2PFM A;  2QVE A;  4C5R A;  4ADM A;  2O6Y A;  1W27 A;  4APA A;  1C3C A;  4BAA A;  4MX2 A;  1YIS A;  1K62 A;  3TV2 A;  3NZ4 A;  4C5U A;  2NYN A;  1GKJ A;  3UNV A;  1FUP A;  1TJU A;  4V2R A;  1AUW A;  3C8T A;  1YFM A;  5D6B A;  1K7W A;  1JSW A;  3GZH A;  4C5S A;  4FFX A;  4APB A;  3OCE A;  1J3U A;  1T6P A;  4EEI A;  4NLE A;  2NYF A;  2PTQ A;  1TJV A;  4HGV A;  1HY0 A;  4FLC A;  1GK2 A;  3RD8 A;  4EFC A;  1FUR A;  3R6V A;  1DOF A;  2J91 A;  1HY1 A;  2O78 A;  2O7D A;  1TJ7 A;  3GTD A;  1Q5N A;  3OCF A;  1C3U A;  4ADL A;  3KDY A;  1GKM A;  2RJR A;  5EYT A;  1B8F A;  1VDK A;  3CZO A;  1GK3 A;  1RE5 A;  5F91 A;  1XWO A;  4V2Q A;  3BHG A;  1I0A A;  5EYV A;  3R6Y A;  2YII A;  2PTR A;  1U16 A;  2OHY A;  2PTS A;  2VD6 A;  3QBP A;  1FUQ A;  1FUO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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