1T6JA

Crystal structure of phenylalanine ammonia lyase from rhodosporidium toruloides
Total Genus 233
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
233
sequence length
676
structure length
646
Chain Sequence
TTQVTQVDIVEKMLAAPTDSTLELDGYSLNLGDVVSAARKGRPVRVKDSDEIRSKIDKSVEFLRSQTEDAISLQKALLEHQLCGVLPSSFDSFRLGRGLENSLPLEVVRGAMTIRVNSLTRGHSAVRLVVLEALTNFLNHGITPIVPLRGTISDLSPLSYIAAAISGHPDSKVHVVHEGKEKILYAREAMALFNLEPVVLGPKEGLGLVNGTAVSASMATLALHDAHMLSLLSQSLTAMTVEAMVGHAGSFHPFLHDVTRPHPTQIEVAGNIRKLLEGSRFAVHHEEERQDRYPLRTSPQWLGPLVSDLIHAHAVLTIEAGQSTTDNPLIDVENKTSHHGGNFQAAAVANTMEKTRLGLAQIGKLNFTQLTEMLNAGMNRGLPSCLAAEDPSLSYHCKGLDIAAAAYTSELGHLANPVTTHVQPAEMANQAVNSLALISARRTTESNDVLSLLLATHLYCVLQAIDLRAIEFEFKKQFGPAIVSLIDQHFGSAMTGSNLRDELVEKVNKTLAKRLEQTNSYDLVPRWHDAFSFAAGTVVEVLSSTSLSLAAVNAWKVAAAESAISLTRQVRETFWSAASTSSPALSYLSPRTQILYAFVREELGVKARRGDVFLGKQEVTIGSNVSKIYEAIKSGRINNVLLKMLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords phenylalanine ammonia-lyase
publication title Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis.
pubmed doi rcsb
source organism Rhodosporidium toruloides
molecule tags Lyase
total genus 233
structure length 646
sequence length 676
chains with identical sequence B
ec nomenclature ec 4.3.1.25: Phenylalanine/tyrosine ammonia-lyase.
pdb deposition date 2004-05-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1t6jA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1t6jA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1t6jA02
3BHGA 4C5SA 2PTSA 4APAA 5F92A 4MX2A 4NSLA 1TJUA 2VD6A 5EYTA 1T6PA 4BAAA 2O7EA 1K7WA 1FUPA 3GZHA 2HVGA 3CZOA 1YFMA 1Q5NA 2QVEA 4HGVA 2O6YA 1EB4A 3UNVA 1GKMA 2YIIA 5HW2A 4BABA 3RD8A 4EFCA 3R6YA 3QBPA 1C3UA 2NYNA 1U15A 2OHYA 1C3CA 1K62A 5F91A 5EYVA 4CQ5A 1FUQA 3E04A 2O7BA 1I0AA 1GK2A 2PTRA 2RJRA 3KDYA 1YFEA 2PFMA 1HY1A 3RRPA 2X75A 2PTQA 4V2QA 2O78A 3R6VA 3OCEA 1W27A 2J91A 1TJ7A 1U16A 2O7DA 1FURA 3TV2A 1AUWA 1Y2MA 1RE5A 1TJVA 3NO9A 3OCFA 2NYFA 1B8FA 1GKJA 1HY0A 4FFXA 4APBA 3R6QA 1KQ7A 5D6BA 4NLEA 4FLCA 1VDKA 4ADLA 4EEIA 2O7FA 1J3UA 1FUOA 1JSWA 1DCNA 1DOFA 2RJSA 2QGAB 1YISA 2E9FA 4C6GA 4C5RA 4ADMA 4V2RA 1TJWA 3GTDA 4C5UA 1GK3A 3C8TA 3NZ4A 1XWOA 1T6JA 3KDZA 2FUSA
chains in the Genus database with same CATH superfamily
2HROA 3GTJA 1XL8A 2LPJA 2R93A 3LR2A 3BHGA 4C5SA 2PTSA 5IZ2A 4APAA 4MX2A 5F92A 3LR8A 4NSLA 2MQAA 1TJUA 2VD6A 4FBSA 5EYTA 1T6PA 4BAAA 2O7EA 1K7WA 2MX8A 1FUPA 1YNND 3GZHA 2HVGA 3EZAA 3GTOA 2FIOA 2LTHA 3CZOA 2A6HD 1YFMA 4C2MA 1Q5NA 2VSFA 2QVEA 4HGVA 2O6YA 1EB4A 3GTMA 3EZBA 1I50A 2F5JA 1GKMA 3UNVA 2YIIA 1K83A 1ZYMA 2MX9A 5HW2A 4BABA 3RD8A 2X0QA 4EFCA 2A6ED 1SFOA 3R6YA 3QBPA 2HWGA 1C3UA 2NYNA 1SMYD 1U15A 3EZEA 2OHYA 1C3CA 1K62A 1ZYRD 5F91A 5EYVA 1WCMA 4CQ5A 1FUQA 3E04A 2CW0D 1I0AA 1GK2A 2BE5D 2O7BA 1XL7A 3GTLA 2O5JD 2PTRA 2RJRA 3KDYA 2AQLA 1XMDA 1YFEA 2PFMA 4QIWA 1HY1A 2VUMA 2NVXA 2R92A 2X75A 3RRPA 2X0PA 4V2QA 2PTQA 2FIPA 2O78A 3LRDA 3OCEA 3R6VA 5H8WA 1W27A 4CEHA 2R7ZA 3LR6A 3GTPA 2JA5A 2J91A 1TJ7A 2EZCA 1U16A 1IW7D 2O7DA 1FURA 5M0IA 2Y0NA 1TWAA 3U4QA 2X0OA 4CEIA 2E2IA 1I3QA 1AUWA 1Y2MA 3TV2A 2NVYA 1RE5A 1TJVA 3NO9A 2N1DB 2NYFA 3OCFA 1B8FA 4CEJA 2EZAA 2VK9A 1GKJA 3H0GA 1TWFA 1I6VD 1Y1WA 1TWCA 1YNJD 1HY0A 1HQMD 5M0JA 2B63A 4FFXA 4APBA 1EZBA 2K3OA 2LKMB 3R6QA 1KQ7A 5D6BA 3U44A 1TWHA 4NLEA 2FENA 4FLCA 1VDKA 4ADLA 4EEIA 2EZBA 2YU9A 1TWGA 2O7FA 2JA6A 2JA7A 1J3UA 2E2HA 3CRVA 2FELA 1FUOA 1JSWA 1DCNA 1DOFA 2RJSA 2LPIA 2QGAB 1XLYA 2A68D 1YISA 4A15A 2MP0A 2E9FA 4C6GA 1XMCA 4C5RA 3CRW1 2N3EA 3CQZA 4V2RA 3GTKA 2K3QA 1TJWA 3GTDA 4ADMA 3FKIA 2VL7A 4C5UA 1GK3A 3GTGA 2LYIA 3GTQA 4WNLA 3C8TA 1R9TA 2A69D 3NZ4A 1EZAA 1XWOA 1T6JA 3KDZA 1Y1VA 2FUSA 2K3NA
chains in the Genus database with same CATH topology
3BHGA 4C5SA 2PTSA 4APAA 5F92A 4MX2A 4NSLA 1TJUA 2VD6A 5EYTA 1T6PA 4BAAA 2O7EA 1K7WA 1FUPA 3GZHA 2HVGA 3CZOA 1YFMA 1Q5NA 2QVEA 4HGVA 2O6YA 1EB4A 3UNVA 1GKMA 2YIIA 5HW2A 4BABA 3RD8A 4EFCA 3R6YA 3QBPA 1C3UA 2NYNA 1U15A 2OHYA 1C3CA 1K62A 5F91A 5EYVA 4CQ5A 1FUQA 3E04A 2O7BA 1I0AA 1GK2A 2PTRA 2RJRA 3KDYA 1YFEA 2PFMA 1HY1A 3RRPA 2X75A 2PTQA 4V2QA 2O78A 3R6VA 3OCEA 1W27A 2J91A 1TJ7A 1U16A 2O7DA 1FURA 3TV2A 1AUWA 1Y2MA 1RE5A 1TJVA 3NO9A 3OCFA 2NYFA 1B8FA 1GKJA 1HY0A 4FFXA 4APBA 3R6QA 1KQ7A 5D6BA 4NLEA 4FLCA 1VDKA 4ADLA 4EEIA 2O7FA 1J3UA 1FUOA 1JSWA 1DCNA 1DOFA 2RJSA 2QGAB 1YISA 2E9FA 4C6GA 4C5RA 4ADMA 4V2RA 1TJWA 3GTDA 4C5UA 1GK3A 3C8TA 3NZ4A 1XWOA 1T6JA 3KDZA 2FUSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BHG A;  4C5S A;  2PTS A;  4APA A;  5F92 A;  4MX2 A;  4NSL A;  1TJU A;  2VD6 A;  5EYT A;  1T6P A;  4BAA A;  2O7E A;  1K7W A;  1FUP A;  3GZH A;  2HVG A;  3CZO A;  1YFM A;  1Q5N A;  2QVE A;  4HGV A;  2O6Y A;  1EB4 A;  3UNV A;  1GKM A;  2YII A;  5HW2 A;  4BAB A;  3RD8 A;  4EFC A;  3R6Y A;  3QBP A;  1C3U A;  2NYN A;  1U15 A;  2OHY A;  1C3C A;  1K62 A;  5F91 A;  5EYV A;  4CQ5 A;  1FUQ A;  3E04 A;  2O7B A;  1I0A A;  1GK2 A;  2PTR A;  2RJR A;  3KDY A;  1YFE A;  2PFM A;  1HY1 A;  3RRP A;  2X75 A;  2PTQ A;  4V2Q A;  2O78 A;  3R6V A;  3OCE A;  1W27 A;  2J91 A;  1TJ7 A;  1U16 A;  2O7D A;  1FUR A;  3TV2 A;  1AUW A;  1Y2M A;  1RE5 A;  1TJV A;  3NO9 A;  3OCF A;  2NYF A;  1B8F A;  1GKJ A;  1HY0 A;  4FFX A;  4APB A;  3R6Q A;  1KQ7 A;  5D6B A;  4NLE A;  4FLC A;  1VDK A;  4ADL A;  4EEI A;  2O7F A;  1J3U A;  1FUO A;  1JSW A;  1DCN A;  1DOF A;  2RJS A;  2QGA B;  1YIS A;  2E9F A;  4C6G A;  4C5R A;  4ADM A;  4V2R A;  1TJW A;  3GTD A;  4C5U A;  1GK3 A;  3C8T A;  3NZ4 A;  1XWO A;  1T6J A;  3KDZ A;  2FUS A; 
#chains in the Genus database with same CATH topology
 2HRO A;  3GTJ A;  1XL8 A;  2LPJ A;  2R93 A;  3LR2 A;  3BHG A;  4C5S A;  2PTS A;  5IZ2 A;  4APA A;  4MX2 A;  5F92 A;  3LR8 A;  4NSL A;  2MQA A;  1TJU A;  2VD6 A;  4FBS A;  5EYT A;  1T6P A;  4BAA A;  2O7E A;  1K7W A;  2MX8 A;  1FUP A;  1YNN D;  3GZH A;  2HVG A;  3EZA A;  3GTO A;  2FIO A;  2LTH A;  3CZO A;  2A6H D;  1YFM A;  4C2M A;  1Q5N A;  2VSF A;  2QVE A;  4HGV A;  2O6Y A;  1EB4 A;  3GTM A;  3EZB A;  1I50 A;  2F5J A;  1GKM A;  3UNV A;  2YII A;  1K83 A;  1ZYM A;  2MX9 A;  5HW2 A;  4BAB A;  3RD8 A;  2X0Q A;  4EFC A;  2A6E D;  1SFO A;  3R6Y A;  3QBP A;  2HWG A;  1C3U A;  2NYN A;  1SMY D;  1U15 A;  3EZE A;  2OHY A;  1C3C A;  1K62 A;  1ZYR D;  5F91 A;  5EYV A;  1WCM A;  4CQ5 A;  1FUQ A;  3E04 A;  2CW0 D;  1I0A A;  1GK2 A;  2BE5 D;  2O7B A;  1XL7 A;  3GTL A;  2O5J D;  2PTR A;  2RJR A;  3KDY A;  2AQL A;  1XMD A;  1YFE A;  2PFM A;  4QIW A;  1HY1 A;  2VUM A;  2NVX A;  2R92 A;  2X75 A;  3RRP A;  2X0P A;  4V2Q A;  2PTQ A;  2FIP A;  2O78 A;  3LRD A;  3OCE A;  3R6V A;  5H8W A;  1W27 A;  4CEH A;  2R7Z A;  3LR6 A;  3GTP A;  2JA5 A;  2J91 A;  1TJ7 A;  2EZC A;  1U16 A;  1IW7 D;  2O7D A;  1FUR A;  5M0I A;  2Y0N A;  1TWA A;  3U4Q A;  2X0O A;  4CEI A;  2E2I A;  1I3Q A;  1AUW A;  1Y2M A;  3TV2 A;  2NVY A;  1RE5 A;  1TJV A;  3NO9 A;  2N1D B;  2NYF A;  3OCF A;  1B8F A;  4CEJ A;  2EZA A;  2VK9 A;  1GKJ A;  3H0G A;  1TWF A;  1I6V D;  1Y1W A;  1TWC A;  1YNJ D;  1HY0 A;  1HQM D;  5M0J A;  2B63 A;  4FFX A;  4APB A;  1EZB A;  2K3O A;  2LKM B;  3R6Q A;  1KQ7 A;  5D6B A;  3U44 A;  1TWH A;  4NLE A;  2FEN A;  4FLC A;  1VDK A;  4ADL A;  4EEI A;  2EZB A;  2YU9 A;  1TWG A;  2O7F A;  2JA6 A;  2JA7 A;  1J3U A;  2E2H A;  3CRV A;  2FEL A;  1FUO A;  1JSW A;  1DCN A;  1DOF A;  2RJS A;  2LPI A;  2QGA B;  1XLY A;  2A68 D;  1YIS A;  4A15 A;  2MP0 A;  2E9F A;  4C6G A;  1XMC A;  4C5R A;  3CRW 1;  2N3E A;  3CQZ A;  4V2R A;  3GTK A;  2K3Q A;  1TJW A;  3GTD A;  4ADM A;  3FKI A;  2VL7 A;  4C5U A;  1GK3 A;  3GTG A;  2LYI A;  3GTQ A;  4WNL A;  3C8T A;  1R9T A;  2A69 D;  3NZ4 A;  1EZA A;  1XWO A;  1T6J A;  3KDZ A;  1Y1V A;  2FUS A;  2K3N A; 
#chains in the Genus database with same CATH homology
 3BHG A;  4C5S A;  2PTS A;  4APA A;  5F92 A;  4MX2 A;  4NSL A;  1TJU A;  2VD6 A;  5EYT A;  1T6P A;  4BAA A;  2O7E A;  1K7W A;  1FUP A;  3GZH A;  2HVG A;  3CZO A;  1YFM A;  1Q5N A;  2QVE A;  4HGV A;  2O6Y A;  1EB4 A;  3UNV A;  1GKM A;  2YII A;  5HW2 A;  4BAB A;  3RD8 A;  4EFC A;  3R6Y A;  3QBP A;  1C3U A;  2NYN A;  1U15 A;  2OHY A;  1C3C A;  1K62 A;  5F91 A;  5EYV A;  4CQ5 A;  1FUQ A;  3E04 A;  2O7B A;  1I0A A;  1GK2 A;  2PTR A;  2RJR A;  3KDY A;  1YFE A;  2PFM A;  1HY1 A;  3RRP A;  2X75 A;  2PTQ A;  4V2Q A;  2O78 A;  3R6V A;  3OCE A;  1W27 A;  2J91 A;  1TJ7 A;  1U16 A;  2O7D A;  1FUR A;  3TV2 A;  1AUW A;  1Y2M A;  1RE5 A;  1TJV A;  3NO9 A;  3OCF A;  2NYF A;  1B8F A;  1GKJ A;  1HY0 A;  4FFX A;  4APB A;  3R6Q A;  1KQ7 A;  5D6B A;  4NLE A;  4FLC A;  1VDK A;  4ADL A;  4EEI A;  2O7F A;  1J3U A;  1FUO A;  1JSW A;  1DCN A;  1DOF A;  2RJS A;  2QGA B;  1YIS A;  2E9F A;  4C6G A;  4C5R A;  4ADM A;  4V2R A;  1TJW A;  3GTD A;  4C5U A;  1GK3 A;  3C8T A;  3NZ4 A;  1XWO A;  1T6J A;  3KDZ A;  2FUS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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