1T6JA

Crystal structure of phenylalanine ammonia lyase from rhodosporidium toruloides
Total Genus 233
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
233
sequence length
676
structure length
646
Chain Sequence
b'TTQVTQVDIVEKMLAAPTDSTLELDGYSLNLGDVVSAARKGRPVRVKDSDEIRSKIDKSVEFLRSQTEDAISLQKALLEHQLCGVLPSSFDSFRLGRGLENSLPLEVVRGAMTIRVNSLTRGHSAVRLVVLEALTNFLNHGITPIVPLRGTISDLSPLSYIAAAISGHPDSKVHVVHEGKEKILYAREAMALFNLEPVVLGPKEGLGLVNGTAVSASMATLALHDAHMLSLLSQSLTAMTVEAMVGHAGSFHPFLHDVTRPHPTQIEVAGNIRKLLEGSRFAVHHEEERQDRYPLRTSPQWLGPLVSDLIHAHAVLTIEAGQSTTDNPLIDVENKTSHHGGNFQAAAVANTMEKTRLGLAQIGKLNFTQLTEMLNAGMNRGLPSCLAAEDPSLSYHCKGLDIAAAAYTSELGHLANPVTTHVQPAEMANQAVNSLALISARRTTESNDVLSLLLATHLYCVLQAIDLRAIEFEFKKQFGPAIVSLIDQHFGSAMTGSNLRDELVEKVNKTLAKRLEQTNSYDLVPRWHDAFSFAAGTVVEVLSSTSLSLAAVNAWKVAAAESAISLTRQVRETFWSAASTSSPALSYLSPRTQILYAFVREELGVKARRGDVFLGKQEVTIGSNVSKIYEAIKSGRINNVLLKMLA'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords phenylalanine ammonia-lyase
publication title Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis.
pubmed doi rcsb
source organism Rhodosporidium toruloides
molecule tags Lyase
total genus 233
structure length 646
sequence length 676
chains with identical sequence B
ec nomenclature ec 4.3.1.25: Phenylalanine/tyrosine ammonia-lyase.
pdb deposition date 2004-05-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1t6jA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1t6jA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1t6jA02
1HY0A 1U16A 4FLCA 3R6QA 1TJWA 1GKMA 3KDYA 2O7EA 3TV2A 3GZHA 1YFMA 1TJUA 2O6YA 3RRPA 1DCNA 2NYNA 1TJ7A 1VDKA 3NO9A 1Q5NA 1AUWA 1DOFA 3C8TA 1T6JA 4CQ5A 1FUOA 2HVGA 4C5SA 5EYVA 4V2RA 4C5UA 4C5RA 4ADMA 3RD8A 1RE5A 4NSLA 4BABA 4NLEA 3UNVA 1GKJA 2O7BA 2RJSA 3QBPA 2QGAB 3CZOA 5HW2A 1K62A 2X75A 2O78A 1YISA 1XWOA 3BHGA 3NZ4A 2NYFA 4EEIA 4HGVA 2RJRA 2E9FA 4ADLA 3R6VA 2PTQA 4FFXA 4APAA 1KQ7A 5F92A 4BAAA 1I0AA 1U15A 2FUSA 4V2QA 2YIIA 1HY1A 1T6PA 2OHYA 2J91A 1TJVA 3E04A 2PTSA 1C3UA 2PTRA 5EYTA 3R6YA 5F91A 2QVEA 2O7FA 4C6GA 1FUQA 3GTDA 1C3CA 1GK3A 1GK2A 5D6BA 2VD6A 1Y2MA 3OCEA 1EB4A 1YFEA 1J3UA 3KDZA 1B8FA 1JSWA 1FURA 4MX2A 4APBA 2O7DA 1FUPA 1W27A 3OCFA 4EFCA 2PFMA 1K7WA
chains in the Genus database with same CATH superfamily
1HY0A 1U16A 4FLCA 3R6QA 1I50A 3GTJA 2B63A 1TJWA 1GKMA 1XL8A 1TWGA 3KDYA 2O7EA 3TV2A 2YU9A 3LR6A 3GZHA 2FIOA 2E2HA 1TJUA 1YFMA 2JA7A 2O6YA 3RRPA 1DCNA 2NYNA 1I3QA 1TJ7A 2FENA 1VDKA 3NO9A 1Q5NA 3GTQA 1Y1WA 1TWFA 1XMCA 2BE5D 2A6HD 1AUWA 1DOFA 3C8TA 1T6JA 1TWAA 2Y0NA 2X0OA 3H0GA 4CQ5A 1FUOA 2HVGA 3LR2A 1XMDA 1Y1VA 2R7ZA 1SFOA 4C5SA 3GTOA 1WCMA 5EYVA 4CEIA 3GTGA 2LKMB 2X0QA 3U4QA 4V2RA 2CW0D 4C5UA 4C5RA 2NVXA 3RD8A 4ADMA 1XL7A 1RE5A 4NSLA 1TWCA 2EZBA 4BABA 4NLEA 3UNVA 1GKJA 2O7BA 3GTPA 2RJSA 3QBPA 2MX9A 3EZAA 3U44A 1R9TA 2R93A 2QGAB 3CZOA 5HW2A 5M0JA 1K62A 2X75A 5IZ2A 2O78A 1YISA 1YNND 4C2MA 1XWOA 1HQMD 2FIPA 2LPJA 2VK9A 4QIWA 2LPIA 3BHGA 3NZ4A 2NYFA 2LYIA 4EEIA 4FBSA 1EZBA 4HGVA 1EZAA 2RJRA 1K83A 2E9FA 3R6VA 2VUMA 4ADLA 3FKIA 2PTQA 4FFXA 2JA6A 2A6ED 2O5JD 4APAA 1KQ7A 3LR8A 5F92A 4BAAA 1I0AA 2N3EA 1U15A 3GTLA 2FUSA 2HWGA 2FELA 1ZYMA 2AQLA 3LRDA 4V2QA 2YIIA 1HY1A 3CRW1 1T6PA 2OHYA 2LTHA 2J91A 1TJVA 1I6VD 3E04A 3CQZA 2PTSA 1C3UA 2PTRA 5EYTA 3R6YA 1TWHA 2K3NA 5F91A 4WNLA 5M0IA 2EZCA 1ZYRD 2K3QA 2A69D 2E2IA 2QVEA 2O7FA 2A68D 2JA5A 4C6GA 2NVYA 2F5JA 3EZEA 2N1DB 1FUQA 3GTDA 5H8WA 2VL7A 2X0PA 4CEJA 3GTMA 1C3CA 1GK3A 1GK2A 3CRVA 2VD6A 1Y2MA 1IW7D 4CEHA 5D6BA 3OCEA 1EB4A 1YFEA 1SMYD 1J3UA 2MX8A 3KDZA 1B8FA 4A15A 1JSWA 1FURA 4MX2A 1XLYA 2HROA 2MQAA 4APBA 1YNJD 2O7DA 3EZBA 1FUPA 2EZAA 1W27A 2VSFA 3OCFA 4EFCA 2PFMA 3GTKA 2K3OA 2R92A 1K7WA 2MP0A
chains in the Genus database with same CATH topology
1HY0A 1U16A 4FLCA 3R6QA 1TJWA 1GKMA 3KDYA 2O7EA 3TV2A 3GZHA 1YFMA 1TJUA 2O6YA 3RRPA 1DCNA 2NYNA 1TJ7A 1VDKA 3NO9A 1Q5NA 1AUWA 1DOFA 3C8TA 1T6JA 4CQ5A 1FUOA 2HVGA 4C5SA 5EYVA 4V2RA 4C5UA 4C5RA 4ADMA 3RD8A 1RE5A 4NSLA 4BABA 4NLEA 3UNVA 1GKJA 2O7BA 2RJSA 3QBPA 2QGAB 3CZOA 5HW2A 1K62A 2X75A 2O78A 1YISA 1XWOA 3BHGA 3NZ4A 2NYFA 4EEIA 4HGVA 2RJRA 2E9FA 4ADLA 3R6VA 2PTQA 4FFXA 4APAA 1KQ7A 5F92A 4BAAA 1I0AA 1U15A 2FUSA 4V2QA 2YIIA 1HY1A 1T6PA 2OHYA 2J91A 1TJVA 3E04A 2PTSA 1C3UA 2PTRA 5EYTA 3R6YA 5F91A 2QVEA 2O7FA 4C6GA 1FUQA 3GTDA 1C3CA 1GK3A 1GK2A 5D6BA 2VD6A 1Y2MA 3OCEA 1EB4A 1YFEA 1J3UA 3KDZA 1B8FA 1JSWA 1FURA 4MX2A 4APBA 2O7DA 1FUPA 1W27A 3OCFA 4EFCA 2PFMA 1K7WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HY0 A;  1U16 A;  4FLC A;  3R6Q A;  1TJW A;  1GKM A;  3KDY A;  2O7E A;  3TV2 A;  3GZH A;  1YFM A;  1TJU A;  2O6Y A;  3RRP A;  1DCN A;  2NYN A;  1TJ7 A;  1VDK A;  3NO9 A;  1Q5N A;  1AUW A;  1DOF A;  3C8T A;  1T6J A;  4CQ5 A;  1FUO A;  2HVG A;  4C5S A;  5EYV A;  4V2R A;  4C5U A;  4C5R A;  4ADM A;  3RD8 A;  1RE5 A;  4NSL A;  4BAB A;  4NLE A;  3UNV A;  1GKJ A;  2O7B A;  2RJS A;  3QBP A;  2QGA B;  3CZO A;  5HW2 A;  1K62 A;  2X75 A;  2O78 A;  1YIS A;  1XWO A;  3BHG A;  3NZ4 A;  2NYF A;  4EEI A;  4HGV A;  2RJR A;  2E9F A;  4ADL A;  3R6V A;  2PTQ A;  4FFX A;  4APA A;  1KQ7 A;  5F92 A;  4BAA A;  1I0A A;  1U15 A;  2FUS A;  4V2Q A;  2YII A;  1HY1 A;  1T6P A;  2OHY A;  2J91 A;  1TJV A;  3E04 A;  2PTS A;  1C3U A;  2PTR A;  5EYT A;  3R6Y A;  5F91 A;  2QVE A;  2O7F A;  4C6G A;  1FUQ A;  3GTD A;  1C3C A;  1GK3 A;  1GK2 A;  5D6B A;  2VD6 A;  1Y2M A;  3OCE A;  1EB4 A;  1YFE A;  1J3U A;  3KDZ A;  1B8F A;  1JSW A;  1FUR A;  4MX2 A;  4APB A;  2O7D A;  1FUP A;  1W27 A;  3OCF A;  4EFC A;  2PFM A;  1K7W A; 
#chains in the Genus database with same CATH topology
 1HY0 A;  1U16 A;  4FLC A;  3R6Q A;  1I50 A;  3GTJ A;  2B63 A;  1TJW A;  1GKM A;  1XL8 A;  1TWG A;  3KDY A;  2O7E A;  3TV2 A;  2YU9 A;  3LR6 A;  3GZH A;  2FIO A;  2E2H A;  1TJU A;  1YFM A;  2JA7 A;  2O6Y A;  3RRP A;  1DCN A;  2NYN A;  1I3Q A;  1TJ7 A;  2FEN A;  1VDK A;  3NO9 A;  1Q5N A;  3GTQ A;  1Y1W A;  1TWF A;  1XMC A;  2BE5 D;  2A6H D;  1AUW A;  1DOF A;  3C8T A;  1T6J A;  1TWA A;  2Y0N A;  2X0O A;  3H0G A;  4CQ5 A;  1FUO A;  2HVG A;  3LR2 A;  1XMD A;  1Y1V A;  2R7Z A;  1SFO A;  4C5S A;  3GTO A;  1WCM A;  5EYV A;  4CEI A;  3GTG A;  2LKM B;  2X0Q A;  3U4Q A;  4V2R A;  2CW0 D;  4C5U A;  4C5R A;  2NVX A;  3RD8 A;  4ADM A;  1XL7 A;  1RE5 A;  4NSL A;  1TWC A;  2EZB A;  4BAB A;  4NLE A;  3UNV A;  1GKJ A;  2O7B A;  3GTP A;  2RJS A;  3QBP A;  2MX9 A;  3EZA A;  3U44 A;  1R9T A;  2R93 A;  2QGA B;  3CZO A;  5HW2 A;  5M0J A;  1K62 A;  2X75 A;  5IZ2 A;  2O78 A;  1YIS A;  1YNN D;  4C2M A;  1XWO A;  1HQM D;  2FIP A;  2LPJ A;  2VK9 A;  4QIW A;  2LPI A;  3BHG A;  3NZ4 A;  2NYF A;  2LYI A;  4EEI A;  4FBS A;  1EZB A;  4HGV A;  1EZA A;  2RJR A;  1K83 A;  2E9F A;  3R6V A;  2VUM A;  4ADL A;  3FKI A;  2PTQ A;  4FFX A;  2JA6 A;  2A6E D;  2O5J D;  4APA A;  1KQ7 A;  3LR8 A;  5F92 A;  4BAA A;  1I0A A;  2N3E A;  1U15 A;  3GTL A;  2FUS A;  2HWG A;  2FEL A;  1ZYM A;  2AQL A;  3LRD A;  4V2Q A;  2YII A;  1HY1 A;  3CRW 1;  1T6P A;  2OHY A;  2LTH A;  2J91 A;  1TJV A;  1I6V D;  3E04 A;  3CQZ A;  2PTS A;  1C3U A;  2PTR A;  5EYT A;  3R6Y A;  1TWH A;  2K3N A;  5F91 A;  4WNL A;  5M0I A;  2EZC A;  1ZYR D;  2K3Q A;  2A69 D;  2E2I A;  2QVE A;  2O7F A;  2A68 D;  2JA5 A;  4C6G A;  2NVY A;  2F5J A;  3EZE A;  2N1D B;  1FUQ A;  3GTD A;  5H8W A;  2VL7 A;  2X0P A;  4CEJ A;  3GTM A;  1C3C A;  1GK3 A;  1GK2 A;  3CRV A;  2VD6 A;  1Y2M A;  1IW7 D;  4CEH A;  5D6B A;  3OCE A;  1EB4 A;  1YFE A;  1SMY D;  1J3U A;  2MX8 A;  3KDZ A;  1B8F A;  4A15 A;  1JSW A;  1FUR A;  4MX2 A;  1XLY A;  2HRO A;  2MQA A;  4APB A;  1YNJ D;  2O7D A;  3EZB A;  1FUP A;  2EZA A;  1W27 A;  2VSF A;  3OCF A;  4EFC A;  2PFM A;  3GTK A;  2K3O A;  2R92 A;  1K7W A;  2MP0 A; 
#chains in the Genus database with same CATH homology
 1HY0 A;  1U16 A;  4FLC A;  3R6Q A;  1TJW A;  1GKM A;  3KDY A;  2O7E A;  3TV2 A;  3GZH A;  1YFM A;  1TJU A;  2O6Y A;  3RRP A;  1DCN A;  2NYN A;  1TJ7 A;  1VDK A;  3NO9 A;  1Q5N A;  1AUW A;  1DOF A;  3C8T A;  1T6J A;  4CQ5 A;  1FUO A;  2HVG A;  4C5S A;  5EYV A;  4V2R A;  4C5U A;  4C5R A;  4ADM A;  3RD8 A;  1RE5 A;  4NSL A;  4BAB A;  4NLE A;  3UNV A;  1GKJ A;  2O7B A;  2RJS A;  3QBP A;  2QGA B;  3CZO A;  5HW2 A;  1K62 A;  2X75 A;  2O78 A;  1YIS A;  1XWO A;  3BHG A;  3NZ4 A;  2NYF A;  4EEI A;  4HGV A;  2RJR A;  2E9F A;  4ADL A;  3R6V A;  2PTQ A;  4FFX A;  4APA A;  1KQ7 A;  5F92 A;  4BAA A;  1I0A A;  1U15 A;  2FUS A;  4V2Q A;  2YII A;  1HY1 A;  1T6P A;  2OHY A;  2J91 A;  1TJV A;  3E04 A;  2PTS A;  1C3U A;  2PTR A;  5EYT A;  3R6Y A;  5F91 A;  2QVE A;  2O7F A;  4C6G A;  1FUQ A;  3GTD A;  1C3C A;  1GK3 A;  1GK2 A;  5D6B A;  2VD6 A;  1Y2M A;  3OCE A;  1EB4 A;  1YFE A;  1J3U A;  3KDZ A;  1B8F A;  1JSW A;  1FUR A;  4MX2 A;  4APB A;  2O7D A;  1FUP A;  1W27 A;  3OCF A;  4EFC A;  2PFM A;  1K7W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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