1T6JA

Crystal structure of phenylalanine ammonia lyase from rhodosporidium toruloides
Total Genus 233
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
233
sequence length
676
structure length
646
Chain Sequence
TTQVTQVDIVEKMLAAPTDSTLELDGYSLNLGDVVSAARKGRPVRVKDSDEIRSKIDKSVEFLRSQTEDAISLQKALLEHQLCGVLPSSFDSFRLGRGLENSLPLEVVRGAMTIRVNSLTRGHSAVRLVVLEALTNFLNHGITPIVPLRGTISDLSPLSYIAAAISGHPDSKVHVVHEGKEKILYAREAMALFNLEPVVLGPKEGLGLVNGTAVSASMATLALHDAHMLSLLSQSLTAMTVEAMVGHAGSFHPFLHDVTRPHPTQIEVAGNIRKLLEGSRFAVHHEEERQDRYPLRTSPQWLGPLVSDLIHAHAVLTIEAGQSTTDNPLIDVENKTSHHGGNFQAAAVANTMEKTRLGLAQIGKLNFTQLTEMLNAGMNRGLPSCLAAEDPSLSYHCKGLDIAAAAYTSELGHLANPVTTHVQPAEMANQAVNSLALISARRTTESNDVLSLLLATHLYCVLQAIDLRAIEFEFKKQFGPAIVSLIDQHFGSAMTGSNLRDELVEKVNKTLAKRLEQTNSYDLVPRWHDAFSFAAGTVVEVLSSTSLSLAAVNAWKVAAAESAISLTRQVRETFWSAASTSSPALSYLSPRTQILYAFVREELGVKARRGDVFLGKQEVTIGSNVSKIYEAIKSGRINNVLLKMLA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis.
pubmed doi rcsb
source organism Rhodosporidium toruloides
molecule tags Lyase
molecule keywords phenylalanine ammonia-lyase
total genus 233
structure length 646
sequence length 676
chains with identical sequence B
ec nomenclature ec 4.3.1.25: Phenylalanine/tyrosine ammonia-lyase.
pdb deposition date 2004-05-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1t6jA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1t6jA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1t6jA02
4EEIA 1U15A 1GKMA 2HVGA 1T6JA 2YIIA 1TJVA 5EYTA 1HY1A 4ADLA 5EYVA 1DOFA 1EB4A 2PTSA 4V2RA 4C6GA 3R6VA 3GZHA 2O78A 2RJRA 3GTDA 2O7EA 4BABA 3R6YA 3UNVA 1KQ7A 1FUOA 1I0AA 1U16A 4NLEA 1GK3A 5HW2A 1YFEA 1FUPA 2X75A 3OCEA 1TJUA 3TV2A 1Q5NA 2QGAB 1JSWA 2PFMA 5D6BA 1TJWA 1DCNA 4FLCA 4MX2A 3BHGA 1HY0A 2VD6A 2FUSA 1C3CA 1FUQA 2E9FA 1GK2A 4CQ5A 3RD8A 2J91A 2O6YA 4APBA 3OCFA 2QVEA 4NSLA 4V2QA 2O7DA 2OHYA 4FFXA 1YISA 2NYFA 4C5SA 4HGVA 1Y2MA 2PTQA 3NO9A 3C8TA 1RE5A 3QBPA 3R6QA 1C3UA 1GKJA 2O7FA 1AUWA 1FURA 2PTRA 3CZOA 5F91A 3NZ4A 4C5UA 4APAA 3E04A 2O7BA 2NYNA 1K62A 3KDYA 1J3UA 4ADMA 1VDKA 5F92A 3RRPA 4C5RA 2RJSA 1B8FA 1K7WA 4EFCA 1T6PA 4BAAA 1TJ7A 1XWOA 3KDZA 1W27A 1YFMA
chains in the Genus database with same CATH superfamily
4EEIA 2O5JD 2Y0NA 4WNLA 1U15A 1GKMA 2YU9A 3GTKA 2HVGA 2X0QA 1T6JA 2YIIA 4CEJA 3GTLA 2B63A 1TJVA 5EYTA 1HY1A 5M0JA 4ADLA 1SFOA 2JA5A 3LR6A 5EYVA 2N3EA 1DOFA 1EB4A 2PTSA 3CQZA 4V2RA 4C6GA 3R6VA 2LPJA 3GZHA 5H8WA 2O78A 3EZEA 1YNND 2VUMA 1I3QA 3LR8A 2R92A 2RJRA 1EZAA 2O7EA 3GTDA 2E2HA 2VL7A 4CEHA 4BABA 3R6YA 3UNVA 2MQAA 1ZYMA 2EZCA 3GTMA 2FIOA 3GTQA 2EZAA 1KQ7A 3H0GA 2A68D 2MX9A 1TWFA 2MP0A 1FUOA 2JA7A 3U4QA 4C2MA 1I0AA 3U44A 1U16A 2LYIA 3CRW1 4A15A 2X0PA 4NLEA 1GK3A 5HW2A 2FIPA 2NVYA 2A6ED 4FBSA 1EZBA 3EZAA 4CEIA 2X0OA 1FUPA 5IZ2A 1YFEA 2X75A 5M0IA 1R9TA 3OCEA 2F5JA 1TJUA 3TV2A 1Q5NA 2QGAB 1JSWA 2LTHA 2PFMA 5D6BA 2E2IA 1TJWA 2VK9A 1DCNA 1XL7A 1I6VD 2LPIA 3EZBA 1XMCA 4FLCA 4MX2A 3BHGA 1HY0A 2N1DB 2VD6A 2FUSA 2A6HD 1HQMD 1WCMA 1TWHA 2K3NA 1C3CA 2HROA 1IW7D 1XMDA 1FUQA 2E9FA 1GK2A 4CQ5A 3RD8A 3GTJA 3GTOA 2J91A 2O6YA 4APBA 2BE5D 1TWGA 2AQLA 3OCFA 3CRVA 2QVEA 4NSLA 3LR2A 2NVXA 2FELA 1XL8A 1TWCA 4V2QA 2O7DA 2OHYA 2MX8A 1K83A 2VSFA 1XLYA 4FFXA 3GTPA 1YISA 2NYFA 4C5SA 4HGVA 1Y2MA 3GTGA 2PTQA 3NO9A 3C8TA 1RE5A 3QBPA 3R6QA 2K3QA 1C3UA 1GKJA 2LKMB 1TWAA 2EZBA 2O7FA 2A69D 3LRDA 2R93A 2CW0D 1AUWA 1FURA 2PTRA 3CZOA 3NZ4A 4C5UA 1Y1WA 5F91A 4APAA 1I50A 3E04A 2O7BA 2NYNA 2FENA 1Y1VA 3FKIA 1K62A 1YNJD 3KDYA 2R7ZA 1J3UA 4ADMA 1VDKA 5F92A 2K3OA 3RRPA 4C5RA 1SMYD 2RJSA 1B8FA 4QIWA 1K7WA 4EFCA 2HWGA 1T6PA 4BAAA 1ZYRD 1TJ7A 1XWOA 2JA6A 3KDZA 1W27A 1YFMA
chains in the Genus database with same CATH topology
4EEIA 1U15A 1GKMA 2HVGA 1T6JA 2YIIA 1TJVA 5EYTA 1HY1A 4ADLA 5EYVA 1DOFA 1EB4A 2PTSA 4V2RA 4C6GA 3R6VA 3GZHA 2O78A 2RJRA 3GTDA 2O7EA 4BABA 3R6YA 3UNVA 1KQ7A 1FUOA 1I0AA 1U16A 4NLEA 1GK3A 5HW2A 1YFEA 1FUPA 2X75A 3OCEA 1TJUA 3TV2A 1Q5NA 2QGAB 1JSWA 2PFMA 5D6BA 1TJWA 1DCNA 4FLCA 4MX2A 3BHGA 1HY0A 2VD6A 2FUSA 1C3CA 1FUQA 2E9FA 1GK2A 4CQ5A 3RD8A 2J91A 2O6YA 4APBA 3OCFA 2QVEA 4NSLA 4V2QA 2O7DA 2OHYA 4FFXA 1YISA 2NYFA 4C5SA 4HGVA 1Y2MA 2PTQA 3NO9A 3C8TA 1RE5A 3QBPA 3R6QA 1C3UA 1GKJA 2O7FA 1AUWA 1FURA 2PTRA 3CZOA 5F91A 3NZ4A 4C5UA 4APAA 3E04A 2O7BA 2NYNA 1K62A 3KDYA 1J3UA 4ADMA 1VDKA 5F92A 3RRPA 4C5RA 2RJSA 1B8FA 1K7WA 4EFCA 1T6PA 4BAAA 1TJ7A 1XWOA 3KDZA 1W27A 1YFMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EEI A;  1U15 A;  1GKM A;  2HVG A;  1T6J A;  2YII A;  1TJV A;  5EYT A;  1HY1 A;  4ADL A;  5EYV A;  1DOF A;  1EB4 A;  2PTS A;  4V2R A;  4C6G A;  3R6V A;  3GZH A;  2O78 A;  2RJR A;  3GTD A;  2O7E A;  4BAB A;  3R6Y A;  3UNV A;  1KQ7 A;  1FUO A;  1I0A A;  1U16 A;  4NLE A;  1GK3 A;  5HW2 A;  1YFE A;  1FUP A;  2X75 A;  3OCE A;  1TJU A;  3TV2 A;  1Q5N A;  2QGA B;  1JSW A;  2PFM A;  5D6B A;  1TJW A;  1DCN A;  4FLC A;  4MX2 A;  3BHG A;  1HY0 A;  2VD6 A;  2FUS A;  1C3C A;  1FUQ A;  2E9F A;  1GK2 A;  4CQ5 A;  3RD8 A;  2J91 A;  2O6Y A;  4APB A;  3OCF A;  2QVE A;  4NSL A;  4V2Q A;  2O7D A;  2OHY A;  4FFX A;  1YIS A;  2NYF A;  4C5S A;  4HGV A;  1Y2M A;  2PTQ A;  3NO9 A;  3C8T A;  1RE5 A;  3QBP A;  3R6Q A;  1C3U A;  1GKJ A;  2O7F A;  1AUW A;  1FUR A;  2PTR A;  3CZO A;  5F91 A;  3NZ4 A;  4C5U A;  4APA A;  3E04 A;  2O7B A;  2NYN A;  1K62 A;  3KDY A;  1J3U A;  4ADM A;  1VDK A;  5F92 A;  3RRP A;  4C5R A;  2RJS A;  1B8F A;  1K7W A;  4EFC A;  1T6P A;  4BAA A;  1TJ7 A;  1XWO A;  3KDZ A;  1W27 A;  1YFM A; 
#chains in the Genus database with same CATH topology
 4EEI A;  2O5J D;  2Y0N A;  4WNL A;  1U15 A;  1GKM A;  2YU9 A;  3GTK A;  2HVG A;  2X0Q A;  1T6J A;  2YII A;  4CEJ A;  3GTL A;  2B63 A;  1TJV A;  5EYT A;  1HY1 A;  5M0J A;  4ADL A;  1SFO A;  2JA5 A;  3LR6 A;  5EYV A;  2N3E A;  1DOF A;  1EB4 A;  2PTS A;  3CQZ A;  4V2R A;  4C6G A;  3R6V A;  2LPJ A;  3GZH A;  5H8W A;  2O78 A;  3EZE A;  1YNN D;  2VUM A;  1I3Q A;  3LR8 A;  2R92 A;  2RJR A;  1EZA A;  2O7E A;  3GTD A;  2E2H A;  2VL7 A;  4CEH A;  4BAB A;  3R6Y A;  3UNV A;  2MQA A;  1ZYM A;  2EZC A;  3GTM A;  2FIO A;  3GTQ A;  2EZA A;  1KQ7 A;  3H0G A;  2A68 D;  2MX9 A;  1TWF A;  2MP0 A;  1FUO A;  2JA7 A;  3U4Q A;  4C2M A;  1I0A A;  3U44 A;  1U16 A;  2LYI A;  3CRW 1;  4A15 A;  2X0P A;  4NLE A;  1GK3 A;  5HW2 A;  2FIP A;  2NVY A;  2A6E D;  4FBS A;  1EZB A;  3EZA A;  4CEI A;  2X0O A;  1FUP A;  5IZ2 A;  1YFE A;  2X75 A;  5M0I A;  1R9T A;  3OCE A;  2F5J A;  1TJU A;  3TV2 A;  1Q5N A;  2QGA B;  1JSW A;  2LTH A;  2PFM A;  5D6B A;  2E2I A;  1TJW A;  2VK9 A;  1DCN A;  1XL7 A;  1I6V D;  2LPI A;  3EZB A;  1XMC A;  4FLC A;  4MX2 A;  3BHG A;  1HY0 A;  2N1D B;  2VD6 A;  2FUS A;  2A6H D;  1HQM D;  1WCM A;  1TWH A;  2K3N A;  1C3C A;  2HRO A;  1IW7 D;  1XMD A;  1FUQ A;  2E9F A;  1GK2 A;  4CQ5 A;  3RD8 A;  3GTJ A;  3GTO A;  2J91 A;  2O6Y A;  4APB A;  2BE5 D;  1TWG A;  2AQL A;  3OCF A;  3CRV A;  2QVE A;  4NSL A;  3LR2 A;  2NVX A;  2FEL A;  1XL8 A;  1TWC A;  4V2Q A;  2O7D A;  2OHY A;  2MX8 A;  1K83 A;  2VSF A;  1XLY A;  4FFX A;  3GTP A;  1YIS A;  2NYF A;  4C5S A;  4HGV A;  1Y2M A;  3GTG A;  2PTQ A;  3NO9 A;  3C8T A;  1RE5 A;  3QBP A;  3R6Q A;  2K3Q A;  1C3U A;  1GKJ A;  2LKM B;  1TWA A;  2EZB A;  2O7F A;  2A69 D;  3LRD A;  2R93 A;  2CW0 D;  1AUW A;  1FUR A;  2PTR A;  3CZO A;  3NZ4 A;  4C5U A;  1Y1W A;  5F91 A;  4APA A;  1I50 A;  3E04 A;  2O7B A;  2NYN A;  2FEN A;  1Y1V A;  3FKI A;  1K62 A;  1YNJ D;  3KDY A;  2R7Z A;  1J3U A;  4ADM A;  1VDK A;  5F92 A;  2K3O A;  3RRP A;  4C5R A;  1SMY D;  2RJS A;  1B8F A;  4QIW A;  1K7W A;  4EFC A;  2HWG A;  1T6P A;  4BAA A;  1ZYR D;  1TJ7 A;  1XWO A;  2JA6 A;  3KDZ A;  1W27 A;  1YFM A; 
#chains in the Genus database with same CATH homology
 4EEI A;  1U15 A;  1GKM A;  2HVG A;  1T6J A;  2YII A;  1TJV A;  5EYT A;  1HY1 A;  4ADL A;  5EYV A;  1DOF A;  1EB4 A;  2PTS A;  4V2R A;  4C6G A;  3R6V A;  3GZH A;  2O78 A;  2RJR A;  3GTD A;  2O7E A;  4BAB A;  3R6Y A;  3UNV A;  1KQ7 A;  1FUO A;  1I0A A;  1U16 A;  4NLE A;  1GK3 A;  5HW2 A;  1YFE A;  1FUP A;  2X75 A;  3OCE A;  1TJU A;  3TV2 A;  1Q5N A;  2QGA B;  1JSW A;  2PFM A;  5D6B A;  1TJW A;  1DCN A;  4FLC A;  4MX2 A;  3BHG A;  1HY0 A;  2VD6 A;  2FUS A;  1C3C A;  1FUQ A;  2E9F A;  1GK2 A;  4CQ5 A;  3RD8 A;  2J91 A;  2O6Y A;  4APB A;  3OCF A;  2QVE A;  4NSL A;  4V2Q A;  2O7D A;  2OHY A;  4FFX A;  1YIS A;  2NYF A;  4C5S A;  4HGV A;  1Y2M A;  2PTQ A;  3NO9 A;  3C8T A;  1RE5 A;  3QBP A;  3R6Q A;  1C3U A;  1GKJ A;  2O7F A;  1AUW A;  1FUR A;  2PTR A;  3CZO A;  5F91 A;  3NZ4 A;  4C5U A;  4APA A;  3E04 A;  2O7B A;  2NYN A;  1K62 A;  3KDY A;  1J3U A;  4ADM A;  1VDK A;  5F92 A;  3RRP A;  4C5R A;  2RJS A;  1B8F A;  1K7W A;  4EFC A;  1T6P A;  4BAA A;  1TJ7 A;  1XWO A;  3KDZ A;  1W27 A;  1YFM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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