1T6JA

Crystal structure of phenylalanine ammonia lyase from rhodosporidium toruloides
Total Genus 233
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
233
sequence length
676
structure length
646
Chain Sequence
TTQVTQVDIVEKMLAAPTDSTLELDGYSLNLGDVVSAARKGRPVRVKDSDEIRSKIDKSVEFLRSQTEDAISLQKALLEHQLCGVLPSSFDSFRLGRGLENSLPLEVVRGAMTIRVNSLTRGHSAVRLVVLEALTNFLNHGITPIVPLRGTISDLSPLSYIAAAISGHPDSKVHVVHEGKEKILYAREAMALFNLEPVVLGPKEGLGLVNGTAVSASMATLALHDAHMLSLLSQSLTAMTVEAMVGHAGSFHPFLHDVTRPHPTQIEVAGNIRKLLEGSRFAVHHEEERQDRYPLRTSPQWLGPLVSDLIHAHAVLTIEAGQSTTDNPLIDVENKTSHHGGNFQAAAVANTMEKTRLGLAQIGKLNFTQLTEMLNAGMNRGLPSCLAAEDPSLSYHCKGLDIAAAAYTSELGHLANPVTTHVQPAEMANQAVNSLALISARRTTESNDVLSLLLATHLYCVLQAIDLRAIEFEFKKQFGPAIVSLIDQHFGSAMTGSNLRDELVEKVNKTLAKRLEQTNSYDLVPRWHDAFSFAAGTVVEVLSSTSLSLAAVNAWKVAAAESAISLTRQVRETFWSAASTSSPALSYLSPRTQILYAFVREELGVKARRGDVFLGKQEVTIGSNVSKIYEAIKSGRINNVLLKMLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords phenylalanine ammonia-lyase
publication title Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis.
pubmed doi rcsb
source organism Rhodosporidium toruloides
molecule tags Lyase
total genus 233
structure length 646
sequence length 676
chains with identical sequence B
ec nomenclature ec 4.3.1.25: Phenylalanine/tyrosine ammonia-lyase.
pdb deposition date 2004-05-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1t6jA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1t6jA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1t6jA02
5HW2A 3C8TA 3BHGA 1HY1A 4C6GA 2X75A 1U16A 4CQ5A 3QBPA 1FUOA 1Q5NA 1FUPA 2RJRA 3GZHA 2QGAB 1GKMA 1Y2MA 4HGVA 2RJSA 2O7BA 1VDKA 2PTRA 3RRPA 1J3UA 1C3CA 2PTQA 4MX2A 4C5RA 1KQ7A 2FUSA 3R6VA 3TV2A 2QVEA 4NLEA 1I0AA 3OCFA 4V2QA 4ADLA 4FFXA 3R6YA 3OCEA 1K62A 3RD8A 2O7EA 5D6BA 1TJWA 4FLCA 2NYFA 2J91A 2VD6A 1YISA 1FUQA 2E9FA 4NSLA 1YFMA 2O7FA 3NZ4A 3CZOA 4BABA 1HY0A 2OHYA 1TJ7A 2PTSA 5F92A 2O6YA 1GKJA 1EB4A 1T6JA 1XWOA 2O78A 1T6PA 4ADMA 1B8FA 4APAA 1TJVA 5EYVA 1W27A 2NYNA 3E04A 4C5SA 1FURA 4APBA 4V2RA 3GTDA 1TJUA 1RE5A 1C3UA 1DCNA 4EEIA 2PFMA 1AUWA 4BAAA 1JSWA 5F91A 4C5UA 1K7WA 5EYTA 1DOFA 1GK2A 2YIIA 3NO9A 2HVGA 4EFCA 2O7DA 3R6QA 1U15A 3KDZA 1YFEA 3KDYA 1GK3A 3UNVA
chains in the Genus database with same CATH superfamily
2LKMB 5HW2A 2YU9A 2X0OA 3C8TA 1Y1WA 3BHGA 1HY1A 4C6GA 2X75A 1U16A 4CQ5A 3QBPA 2Y0NA 1FUOA 1Q5NA 1FUPA 2RJRA 2N3EA 3GZHA 2QGAB 2BE5D 2MQAA 1GKMA 1Y2MA 2LPJA 4HGVA 2RJSA 1SFOA 2K3OA 3CQZA 4FBSA 2N1DB 3EZBA 3GTMA 2O7BA 2LPIA 1VDKA 1I6VD 4CEJA 2PTRA 3RRPA 3GTJA 2X0PA 1C3CA 1J3UA 1TWAA 2PTQA 4MX2A 2EZAA 2A6HD 4C5RA 2R7ZA 2K3QA 1KQ7A 4QIWA 2FUSA 3CRVA 2FIPA 3R6VA 4CEHA 3TV2A 2R92A 2E2IA 2QVEA 3UNVA 4NLEA 1I0AA 1TWGA 1TWHA 1XMDA 3OCFA 3GTKA 4V2QA 2JA6A 1TWFA 4ADLA 4FFXA 2VL7A 2JA7A 3OCEA 2A69D 3R6YA 1I50A 1K62A 1ZYMA 2VK9A 3RD8A 2O7EA 1I3QA 3GTGA 2K3NA 4A15A 5D6BA 1TJWA 2MX9A 4FLCA 3LR6A 2A68D 5M0IA 2NYFA 2J91A 2VD6A 1YISA 1FUQA 1XLYA 5H8WA 1TWCA 1ZYRD 2A6ED 1HQMD 2E9FA 2MX8A 4NSLA 1YFMA 4WNLA 3H0GA 2O7FA 1YNND 3LR8A 2LYIA 3NZ4A 3CZOA 4BABA 2B63A 1HY0A 2OHYA 1TJ7A 4C2MA 2X0QA 2R93A 2HROA 2F5JA 2PTSA 2FENA 1XL7A 3U4QA 2VUMA 5F92A 3LRDA 2O6YA 1K83A 1GKJA 2HWGA 1T6JA 1EB4A 1XWOA 2O78A 1YNJD 1T6PA 4ADMA 1B8FA 2CW0D 1TJVA 5EYVA 4APAA 1W27A 1Y1VA 2NYNA 3E04A 4C5SA 1FURA 3LR2A 4APBA 1R9TA 4V2RA 3GTDA 2EZBA 1EZBA 1TJUA 2FIOA 2AQLA 2FELA 1RE5A 3GTQA 2EZCA 1C3UA 2VSFA 1DCNA 3GTOA 2LTHA 4EEIA 2PFMA 1EZAA 1AUWA 4BAAA 1JSWA 5F91A 4C5UA 1K7WA 5EYTA 2E2HA 1DOFA 1GK2A 5M0JA 2YIIA 1WCMA 3NO9A 2HVGA 4EFCA 3GTPA 2O7DA 3R6QA 2MP0A 1XMCA 3EZAA 3U44A 3FKIA 2O5JD 1U15A 2NVYA 2NVXA 1SMYD 1IW7D 3GTLA 3KDZA 4CEIA 1YFEA 1XL8A 3EZEA 3KDYA 5IZ2A 3CRW1 1GK3A 2JA5A
chains in the Genus database with same CATH topology
5HW2A 3C8TA 3BHGA 1HY1A 4C6GA 2X75A 1U16A 4CQ5A 3QBPA 1FUOA 1Q5NA 1FUPA 2RJRA 3GZHA 2QGAB 1GKMA 1Y2MA 4HGVA 2RJSA 2O7BA 1VDKA 2PTRA 3RRPA 1J3UA 1C3CA 2PTQA 4MX2A 4C5RA 1KQ7A 2FUSA 3R6VA 3TV2A 2QVEA 4NLEA 1I0AA 3OCFA 4V2QA 4ADLA 4FFXA 3R6YA 3OCEA 1K62A 3RD8A 2O7EA 5D6BA 1TJWA 4FLCA 2NYFA 2J91A 2VD6A 1YISA 1FUQA 2E9FA 4NSLA 1YFMA 2O7FA 3NZ4A 3CZOA 4BABA 1HY0A 2OHYA 1TJ7A 2PTSA 5F92A 2O6YA 1GKJA 1EB4A 1T6JA 1XWOA 2O78A 1T6PA 4ADMA 1B8FA 4APAA 1TJVA 5EYVA 1W27A 2NYNA 3E04A 4C5SA 1FURA 4APBA 4V2RA 3GTDA 1TJUA 1RE5A 1C3UA 1DCNA 4EEIA 2PFMA 1AUWA 4BAAA 1JSWA 5F91A 4C5UA 1K7WA 5EYTA 1DOFA 1GK2A 2YIIA 3NO9A 2HVGA 4EFCA 2O7DA 3R6QA 1U15A 3KDZA 1YFEA 3KDYA 1GK3A 3UNVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HW2 A;  3C8T A;  3BHG A;  1HY1 A;  4C6G A;  2X75 A;  1U16 A;  4CQ5 A;  3QBP A;  1FUO A;  1Q5N A;  1FUP A;  2RJR A;  3GZH A;  2QGA B;  1GKM A;  1Y2M A;  4HGV A;  2RJS A;  2O7B A;  1VDK A;  2PTR A;  3RRP A;  1J3U A;  1C3C A;  2PTQ A;  4MX2 A;  4C5R A;  1KQ7 A;  2FUS A;  3R6V A;  3TV2 A;  2QVE A;  4NLE A;  1I0A A;  3OCF A;  4V2Q A;  4ADL A;  4FFX A;  3R6Y A;  3OCE A;  1K62 A;  3RD8 A;  2O7E A;  5D6B A;  1TJW A;  4FLC A;  2NYF A;  2J91 A;  2VD6 A;  1YIS A;  1FUQ A;  2E9F A;  4NSL A;  1YFM A;  2O7F A;  3NZ4 A;  3CZO A;  4BAB A;  1HY0 A;  2OHY A;  1TJ7 A;  2PTS A;  5F92 A;  2O6Y A;  1GKJ A;  1EB4 A;  1T6J A;  1XWO A;  2O78 A;  1T6P A;  4ADM A;  1B8F A;  4APA A;  1TJV A;  5EYV A;  1W27 A;  2NYN A;  3E04 A;  4C5S A;  1FUR A;  4APB A;  4V2R A;  3GTD A;  1TJU A;  1RE5 A;  1C3U A;  1DCN A;  4EEI A;  2PFM A;  1AUW A;  4BAA A;  1JSW A;  5F91 A;  4C5U A;  1K7W A;  5EYT A;  1DOF A;  1GK2 A;  2YII A;  3NO9 A;  2HVG A;  4EFC A;  2O7D A;  3R6Q A;  1U15 A;  3KDZ A;  1YFE A;  3KDY A;  1GK3 A;  3UNV A; 
#chains in the Genus database with same CATH topology
 2LKM B;  5HW2 A;  2YU9 A;  2X0O A;  3C8T A;  1Y1W A;  3BHG A;  1HY1 A;  4C6G A;  2X75 A;  1U16 A;  4CQ5 A;  3QBP A;  2Y0N A;  1FUO A;  1Q5N A;  1FUP A;  2RJR A;  2N3E A;  3GZH A;  2QGA B;  2BE5 D;  2MQA A;  1GKM A;  1Y2M A;  2LPJ A;  4HGV A;  2RJS A;  1SFO A;  2K3O A;  3CQZ A;  4FBS A;  2N1D B;  3EZB A;  3GTM A;  2O7B A;  2LPI A;  1VDK A;  1I6V D;  4CEJ A;  2PTR A;  3RRP A;  3GTJ A;  2X0P A;  1C3C A;  1J3U A;  1TWA A;  2PTQ A;  4MX2 A;  2EZA A;  2A6H D;  4C5R A;  2R7Z A;  2K3Q A;  1KQ7 A;  4QIW A;  2FUS A;  3CRV A;  2FIP A;  3R6V A;  4CEH A;  3TV2 A;  2R92 A;  2E2I A;  2QVE A;  3UNV A;  4NLE A;  1I0A A;  1TWG A;  1TWH A;  1XMD A;  3OCF A;  3GTK A;  4V2Q A;  2JA6 A;  1TWF A;  4ADL A;  4FFX A;  2VL7 A;  2JA7 A;  3OCE A;  2A69 D;  3R6Y A;  1I50 A;  1K62 A;  1ZYM A;  2VK9 A;  3RD8 A;  2O7E A;  1I3Q A;  3GTG A;  2K3N A;  4A15 A;  5D6B A;  1TJW A;  2MX9 A;  4FLC A;  3LR6 A;  2A68 D;  5M0I A;  2NYF A;  2J91 A;  2VD6 A;  1YIS A;  1FUQ A;  1XLY A;  5H8W A;  1TWC A;  1ZYR D;  2A6E D;  1HQM D;  2E9F A;  2MX8 A;  4NSL A;  1YFM A;  4WNL A;  3H0G A;  2O7F A;  1YNN D;  3LR8 A;  2LYI A;  3NZ4 A;  3CZO A;  4BAB A;  2B63 A;  1HY0 A;  2OHY A;  1TJ7 A;  4C2M A;  2X0Q A;  2R93 A;  2HRO A;  2F5J A;  2PTS A;  2FEN A;  1XL7 A;  3U4Q A;  2VUM A;  5F92 A;  3LRD A;  2O6Y A;  1K83 A;  1GKJ A;  2HWG A;  1T6J A;  1EB4 A;  1XWO A;  2O78 A;  1YNJ D;  1T6P A;  4ADM A;  1B8F A;  2CW0 D;  1TJV A;  5EYV A;  4APA A;  1W27 A;  1Y1V A;  2NYN A;  3E04 A;  4C5S A;  1FUR A;  3LR2 A;  4APB A;  1R9T A;  4V2R A;  3GTD A;  2EZB A;  1EZB A;  1TJU A;  2FIO A;  2AQL A;  2FEL A;  1RE5 A;  3GTQ A;  2EZC A;  1C3U A;  2VSF A;  1DCN A;  3GTO A;  2LTH A;  4EEI A;  2PFM A;  1EZA A;  1AUW A;  4BAA A;  1JSW A;  5F91 A;  4C5U A;  1K7W A;  5EYT A;  2E2H A;  1DOF A;  1GK2 A;  5M0J A;  2YII A;  1WCM A;  3NO9 A;  2HVG A;  4EFC A;  3GTP A;  2O7D A;  3R6Q A;  2MP0 A;  1XMC A;  3EZA A;  3U44 A;  3FKI A;  2O5J D;  1U15 A;  2NVY A;  2NVX A;  1SMY D;  1IW7 D;  3GTL A;  3KDZ A;  4CEI A;  1YFE A;  1XL8 A;  3EZE A;  3KDY A;  5IZ2 A;  3CRW 1;  1GK3 A;  2JA5 A; 
#chains in the Genus database with same CATH homology
 5HW2 A;  3C8T A;  3BHG A;  1HY1 A;  4C6G A;  2X75 A;  1U16 A;  4CQ5 A;  3QBP A;  1FUO A;  1Q5N A;  1FUP A;  2RJR A;  3GZH A;  2QGA B;  1GKM A;  1Y2M A;  4HGV A;  2RJS A;  2O7B A;  1VDK A;  2PTR A;  3RRP A;  1J3U A;  1C3C A;  2PTQ A;  4MX2 A;  4C5R A;  1KQ7 A;  2FUS A;  3R6V A;  3TV2 A;  2QVE A;  4NLE A;  1I0A A;  3OCF A;  4V2Q A;  4ADL A;  4FFX A;  3R6Y A;  3OCE A;  1K62 A;  3RD8 A;  2O7E A;  5D6B A;  1TJW A;  4FLC A;  2NYF A;  2J91 A;  2VD6 A;  1YIS A;  1FUQ A;  2E9F A;  4NSL A;  1YFM A;  2O7F A;  3NZ4 A;  3CZO A;  4BAB A;  1HY0 A;  2OHY A;  1TJ7 A;  2PTS A;  5F92 A;  2O6Y A;  1GKJ A;  1EB4 A;  1T6J A;  1XWO A;  2O78 A;  1T6P A;  4ADM A;  1B8F A;  4APA A;  1TJV A;  5EYV A;  1W27 A;  2NYN A;  3E04 A;  4C5S A;  1FUR A;  4APB A;  4V2R A;  3GTD A;  1TJU A;  1RE5 A;  1C3U A;  1DCN A;  4EEI A;  2PFM A;  1AUW A;  4BAA A;  1JSW A;  5F91 A;  4C5U A;  1K7W A;  5EYT A;  1DOF A;  1GK2 A;  2YII A;  3NO9 A;  2HVG A;  4EFC A;  2O7D A;  3R6Q A;  1U15 A;  3KDZ A;  1YFE A;  3KDY A;  1GK3 A;  3UNV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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