1T6JA

Crystal structure of phenylalanine ammonia lyase from rhodosporidium toruloides
Total Genus 233
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
233
sequence length
676
structure length
646
Chain Sequence
TTQVTQVDIVEKMLAAPTDSTLELDGYSLNLGDVVSAARKGRPVRVKDSDEIRSKIDKSVEFLRSQTEDAISLQKALLEHQLCGVLPSSFDSFRLGRGLENSLPLEVVRGAMTIRVNSLTRGHSAVRLVVLEALTNFLNHGITPIVPLRGTISDLSPLSYIAAAISGHPDSKVHVVHEGKEKILYAREAMALFNLEPVVLGPKEGLGLVNGTAVSASMATLALHDAHMLSLLSQSLTAMTVEAMVGHAGSFHPFLHDVTRPHPTQIEVAGNIRKLLEGSRFAVHHEEERQDRYPLRTSPQWLGPLVSDLIHAHAVLTIEAGQSTTDNPLIDVENKTSHHGGNFQAAAVANTMEKTRLGLAQIGKLNFTQLTEMLNAGMNRGLPSCLAAEDPSLSYHCKGLDIAAAAYTSELGHLANPVTTHVQPAEMANQAVNSLALISARRTTESNDVLSLLLATHLYCVLQAIDLRAIEFEFKKQFGPAIVSLIDQHFGSAMTGSNLRDELVEKVNKTLAKRLEQTNSYDLVPRWHDAFSFAAGTVVEVLSSTSLSLAAVNAWKVAAAESAISLTRQVRETFWSAASTSSPALSYLSPRTQILYAFVREELGVKARRGDVFLGKQEVTIGSNVSKIYEAIKSGRINNVLLKMLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Lyase
molecule keywords phenylalanine ammonia-lyase
publication title Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis.
pubmed doi rcsb
source organism Rhodosporidium toruloides
total genus 233
structure length 646
sequence length 676
chains with identical sequence B
ec nomenclature ec 4.3.1.25: Phenylalanine/tyrosine ammonia-lyase.
pdb deposition date 2004-05-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1t6jA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1t6jA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1t6jA02
2OHYA 3TV2A 4V2RA 1TJUA 2O7DA 3R6QA 4ADLA 1Y2MA 2O7FA 1K7WA 1W27A 3UNVA 3KDYA 3NZ4A 4BABA 1XWOA 4BAAA 5EYVA 1GK3A 2PTRA 1HY1A 1J3UA 4C6GA 1C3CA 3R6VA 2RJSA 3OCEA 1YFMA 5F91A 1GKJA 2RJRA 3KDZA 1B8FA 4C5SA 1KQ7A 1Q5NA 1VDKA 1FUOA 2X75A 1FUPA 4C5RA 2HVGA 4V2QA 1I0AA 1U15A 1FURA 1C3UA 2PFMA 1DCNA 4NLEA 5HW2A 4C5UA 1GK2A 4EEIA 2FUSA 3R6YA 1FUQA 1TJWA 4EFCA 3CZOA 1YISA 3NO9A 2J91A 4HGVA 4FFXA 2O7EA 5F92A 2NYNA 1YFEA 1K62A 2O6YA 1TJ7A 2NYFA 4APAA 3RRPA 5D6BA 5EYTA 1TJVA 3RD8A 3OCFA 2PTQA 3GTDA 2QVEA 2O78A 3GZHA 4MX2A 1HY0A 4NSLA 2E9FA 2PTSA 1JSWA 2VD6A 1EB4A 1T6PA 1RE5A 2QGAB 1DOFA 3BHGA 3E04A 1GKMA 2O7BA 4FLCA 3C8TA 1T6JA 2YIIA 1AUWA 1U16A 3QBPA 4ADMA 4APBA 4CQ5A
chains in the Genus database with same CATH superfamily
2EZCA 2MX9A 2NVYA 2OHYA 4V2RA 3TV2A 2F5JA 2VSFA 1TJUA 2O7DA 3U44A 3R6QA 1TWCA 2YU9A 1YNND 4ADLA 2LYIA 1Y2MA 2B63A 2O7FA 2A6HD 1SMYD 2VUMA 4CEHA 2A6ED 1K7WA 1W27A 3UNVA 3KDYA 5H8WA 3NZ4A 4BABA 3LR8A 1XWOA 4BAAA 5EYVA 1GK3A 1HY1A 1J3UA 3LRDA 2PTRA 2FELA 4C6GA 1C3CA 3R6VA 2RJSA 3OCEA 1YFMA 5F91A 1GKJA 2O5JD 1IW7D 2LPIA 2N1DB 1XMDA 2RJRA 3EZAA 3KDZA 2E2HA 1Y1VA 2X0QA 1TWFA 1B8FA 4C5SA 2R93A 1I3QA 1KQ7A 1Q5NA 4QIWA 2FIOA 1VDKA 3LR2A 4A15A 1FUOA 3GTLA 2X75A 4C2MA 1I50A 1FUPA 2JA5A 4C5RA 2JA7A 1XL7A 2HVGA 4V2QA 1I0AA 1U15A 3FKIA 2LTHA 1C3UA 1FURA 3GTQA 1HQMD 4CEJA 2PFMA 1DCNA 1EZBA 4NLEA 5HW2A 4C5UA 1GK2A 3CRW1 4EEIA 4WNLA 1TWGA 2FUSA 3CRVA 3LR6A 1Y1WA 3R6YA 1FUQA 1TJWA 5M0IA 3CQZA 4EFCA 2EZBA 2HROA 2X0OA 3CZOA 2A68D 1YISA 3EZBA 3NO9A 2J91A 1WCMA 4HGVA 4FFXA 2R7ZA 3GTKA 1K83A 1ZYRD 2MX8A 3U4QA 3H0GA 2O7EA 5F92A 2NYNA 2E2IA 3EZEA 1YFEA 2FENA 1K62A 2O6YA 3GTGA 2FIPA 1TJ7A 2NYFA 1I6VD 4APAA 2EZAA 2JA6A 2AQLA 3RRPA 1TWHA 5D6BA 2K3NA 5EYTA 4FBSA 2MP0A 2R92A 1TJVA 3GTPA 3RD8A 1R9TA 3OCFA 1XLYA 2PTQA 2X0PA 2QVEA 3GTDA 2O78A 2LPJA 2NVXA 2K3QA 3GZHA 4MX2A 1HY0A 2A69D 4NSLA 1TWAA 3GTOA 2E9FA 1EZAA 2PTSA 5IZ2A 3GTMA 2BE5D 1JSWA 2Y0NA 1EB4A 2VD6A 1T6PA 2MQAA 1RE5A 2QGAB 1YNJD 2N3EA 1DOFA 5M0JA 2K3OA 2CW0D 3GTJA 4CEIA 3BHGA 2HWGA 1GKMA 2O7BA 1SFOA 3E04A 4FLCA 3C8TA 2LKMB 2VL7A 1ZYMA 1XL8A 1T6JA 2YIIA 1AUWA 1U16A 3QBPA 4ADMA 4APBA 4CQ5A 2VK9A 1XMCA
chains in the Genus database with same CATH topology
2OHYA 3TV2A 4V2RA 1TJUA 2O7DA 3R6QA 4ADLA 1Y2MA 2O7FA 1K7WA 1W27A 3UNVA 3KDYA 3NZ4A 4BABA 1XWOA 4BAAA 5EYVA 1GK3A 2PTRA 1HY1A 1J3UA 4C6GA 1C3CA 3R6VA 2RJSA 3OCEA 1YFMA 5F91A 1GKJA 2RJRA 3KDZA 1B8FA 4C5SA 1KQ7A 1Q5NA 1VDKA 1FUOA 2X75A 1FUPA 4C5RA 2HVGA 4V2QA 1I0AA 1U15A 1FURA 1C3UA 2PFMA 1DCNA 4NLEA 5HW2A 4C5UA 1GK2A 4EEIA 2FUSA 3R6YA 1FUQA 1TJWA 4EFCA 3CZOA 1YISA 3NO9A 2J91A 4HGVA 4FFXA 2O7EA 5F92A 2NYNA 1YFEA 1K62A 2O6YA 1TJ7A 2NYFA 4APAA 3RRPA 5D6BA 5EYTA 1TJVA 3RD8A 3OCFA 2PTQA 3GTDA 2QVEA 2O78A 3GZHA 4MX2A 1HY0A 4NSLA 2E9FA 2PTSA 1JSWA 2VD6A 1EB4A 1T6PA 1RE5A 2QGAB 1DOFA 3BHGA 3E04A 1GKMA 2O7BA 4FLCA 3C8TA 1T6JA 2YIIA 1AUWA 1U16A 3QBPA 4ADMA 4APBA 4CQ5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2OHY A;  3TV2 A;  4V2R A;  1TJU A;  2O7D A;  3R6Q A;  4ADL A;  1Y2M A;  2O7F A;  1K7W A;  1W27 A;  3UNV A;  3KDY A;  3NZ4 A;  4BAB A;  1XWO A;  4BAA A;  5EYV A;  1GK3 A;  2PTR A;  1HY1 A;  1J3U A;  4C6G A;  1C3C A;  3R6V A;  2RJS A;  3OCE A;  1YFM A;  5F91 A;  1GKJ A;  2RJR A;  3KDZ A;  1B8F A;  4C5S A;  1KQ7 A;  1Q5N A;  1VDK A;  1FUO A;  2X75 A;  1FUP A;  4C5R A;  2HVG A;  4V2Q A;  1I0A A;  1U15 A;  1FUR A;  1C3U A;  2PFM A;  1DCN A;  4NLE A;  5HW2 A;  4C5U A;  1GK2 A;  4EEI A;  2FUS A;  3R6Y A;  1FUQ A;  1TJW A;  4EFC A;  3CZO A;  1YIS A;  3NO9 A;  2J91 A;  4HGV A;  4FFX A;  2O7E A;  5F92 A;  2NYN A;  1YFE A;  1K62 A;  2O6Y A;  1TJ7 A;  2NYF A;  4APA A;  3RRP A;  5D6B A;  5EYT A;  1TJV A;  3RD8 A;  3OCF A;  2PTQ A;  3GTD A;  2QVE A;  2O78 A;  3GZH A;  4MX2 A;  1HY0 A;  4NSL A;  2E9F A;  2PTS A;  1JSW A;  2VD6 A;  1EB4 A;  1T6P A;  1RE5 A;  2QGA B;  1DOF A;  3BHG A;  3E04 A;  1GKM A;  2O7B A;  4FLC A;  3C8T A;  1T6J A;  2YII A;  1AUW A;  1U16 A;  3QBP A;  4ADM A;  4APB A;  4CQ5 A; 
#chains in the Genus database with same CATH topology
 2EZC A;  2MX9 A;  2NVY A;  2OHY A;  4V2R A;  3TV2 A;  2F5J A;  2VSF A;  1TJU A;  2O7D A;  3U44 A;  3R6Q A;  1TWC A;  2YU9 A;  1YNN D;  4ADL A;  2LYI A;  1Y2M A;  2B63 A;  2O7F A;  2A6H D;  1SMY D;  2VUM A;  4CEH A;  2A6E D;  1K7W A;  1W27 A;  3UNV A;  3KDY A;  5H8W A;  3NZ4 A;  4BAB A;  3LR8 A;  1XWO A;  4BAA A;  5EYV A;  1GK3 A;  1HY1 A;  1J3U A;  3LRD A;  2PTR A;  2FEL A;  4C6G A;  1C3C A;  3R6V A;  2RJS A;  3OCE A;  1YFM A;  5F91 A;  1GKJ A;  2O5J D;  1IW7 D;  2LPI A;  2N1D B;  1XMD A;  2RJR A;  3EZA A;  3KDZ A;  2E2H A;  1Y1V A;  2X0Q A;  1TWF A;  1B8F A;  4C5S A;  2R93 A;  1I3Q A;  1KQ7 A;  1Q5N A;  4QIW A;  2FIO A;  1VDK A;  3LR2 A;  4A15 A;  1FUO A;  3GTL A;  2X75 A;  4C2M A;  1I50 A;  1FUP A;  2JA5 A;  4C5R A;  2JA7 A;  1XL7 A;  2HVG A;  4V2Q A;  1I0A A;  1U15 A;  3FKI A;  2LTH A;  1C3U A;  1FUR A;  3GTQ A;  1HQM D;  4CEJ A;  2PFM A;  1DCN A;  1EZB A;  4NLE A;  5HW2 A;  4C5U A;  1GK2 A;  3CRW 1;  4EEI A;  4WNL A;  1TWG A;  2FUS A;  3CRV A;  3LR6 A;  1Y1W A;  3R6Y A;  1FUQ A;  1TJW A;  5M0I A;  3CQZ A;  4EFC A;  2EZB A;  2HRO A;  2X0O A;  3CZO A;  2A68 D;  1YIS A;  3EZB A;  3NO9 A;  2J91 A;  1WCM A;  4HGV A;  4FFX A;  2R7Z A;  3GTK A;  1K83 A;  1ZYR D;  2MX8 A;  3U4Q A;  3H0G A;  2O7E A;  5F92 A;  2NYN A;  2E2I A;  3EZE A;  1YFE A;  2FEN A;  1K62 A;  2O6Y A;  3GTG A;  2FIP A;  1TJ7 A;  2NYF A;  1I6V D;  4APA A;  2EZA A;  2JA6 A;  2AQL A;  3RRP A;  1TWH A;  5D6B A;  2K3N A;  5EYT A;  4FBS A;  2MP0 A;  2R92 A;  1TJV A;  3GTP A;  3RD8 A;  1R9T A;  3OCF A;  1XLY A;  2PTQ A;  2X0P A;  2QVE A;  3GTD A;  2O78 A;  2LPJ A;  2NVX A;  2K3Q A;  3GZH A;  4MX2 A;  1HY0 A;  2A69 D;  4NSL A;  1TWA A;  3GTO A;  2E9F A;  1EZA A;  2PTS A;  5IZ2 A;  3GTM A;  2BE5 D;  1JSW A;  2Y0N A;  1EB4 A;  2VD6 A;  1T6P A;  2MQA A;  1RE5 A;  2QGA B;  1YNJ D;  2N3E A;  1DOF A;  5M0J A;  2K3O A;  2CW0 D;  3GTJ A;  4CEI A;  3BHG A;  2HWG A;  1GKM A;  2O7B A;  1SFO A;  3E04 A;  4FLC A;  3C8T A;  2LKM B;  2VL7 A;  1ZYM A;  1XL8 A;  1T6J A;  2YII A;  1AUW A;  1U16 A;  3QBP A;  4ADM A;  4APB A;  4CQ5 A;  2VK9 A;  1XMC A; 
#chains in the Genus database with same CATH homology
 2OHY A;  3TV2 A;  4V2R A;  1TJU A;  2O7D A;  3R6Q A;  4ADL A;  1Y2M A;  2O7F A;  1K7W A;  1W27 A;  3UNV A;  3KDY A;  3NZ4 A;  4BAB A;  1XWO A;  4BAA A;  5EYV A;  1GK3 A;  2PTR A;  1HY1 A;  1J3U A;  4C6G A;  1C3C A;  3R6V A;  2RJS A;  3OCE A;  1YFM A;  5F91 A;  1GKJ A;  2RJR A;  3KDZ A;  1B8F A;  4C5S A;  1KQ7 A;  1Q5N A;  1VDK A;  1FUO A;  2X75 A;  1FUP A;  4C5R A;  2HVG A;  4V2Q A;  1I0A A;  1U15 A;  1FUR A;  1C3U A;  2PFM A;  1DCN A;  4NLE A;  5HW2 A;  4C5U A;  1GK2 A;  4EEI A;  2FUS A;  3R6Y A;  1FUQ A;  1TJW A;  4EFC A;  3CZO A;  1YIS A;  3NO9 A;  2J91 A;  4HGV A;  4FFX A;  2O7E A;  5F92 A;  2NYN A;  1YFE A;  1K62 A;  2O6Y A;  1TJ7 A;  2NYF A;  4APA A;  3RRP A;  5D6B A;  5EYT A;  1TJV A;  3RD8 A;  3OCF A;  2PTQ A;  3GTD A;  2QVE A;  2O78 A;  3GZH A;  4MX2 A;  1HY0 A;  4NSL A;  2E9F A;  2PTS A;  1JSW A;  2VD6 A;  1EB4 A;  1T6P A;  1RE5 A;  2QGA B;  1DOF A;  3BHG A;  3E04 A;  1GKM A;  2O7B A;  4FLC A;  3C8T A;  1T6J A;  2YII A;  1AUW A;  1U16 A;  3QBP A;  4ADM A;  4APB A;  4CQ5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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