4CQ5A

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 268
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
268
sequence length
667
structure length
638
Chain Sequence
b'SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIAGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTLPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMINOMUTASE
publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 268
structure length 638
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2014-02-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4cq5A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4cq5A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4cq5A02
4EEIA 1FUOA 4APBA 1AUWA 3R6VA 1DCNA 2PFMA 3CZOA 1J3UA 4C6GA 1XWOA 1TJVA 2PTQA 5D6BA 2HVGA 2QGAB 2RJRA 4C5RA 2O6YA 2FUSA 1GKMA 3NZ4A 2NYFA 2O7DA 3NO9A 2O7EA 2RJSA 3C8TA 3QBPA 4BAAA 2O7FA 5EYTA 1B8FA 2YIIA 3KDZA 2NYNA 3GZHA 5F91A 2E9FA 2OHYA 4CQ5A 3OCFA 5HW2A 1C3UA 1T6JA 1GK3A 5F92A 1RE5A 1K7WA 4ADMA 4ADLA 3RRPA 1YFEA 1FUPA 3TV2A 3UNVA 4C5UA 3E04A 2QVEA 1GK2A 1FURA 1DOFA 4BABA 1T6PA 1I0AA 2X75A 4APAA 4EFCA 1TJUA 1TJWA 4C5SA 1FUQA 1K62A 1TJ7A 4FFXA 2O7BA 3R6YA 1U16A 3OCEA 4V2QA 2PTRA 4V2RA 1KQ7A 4NLEA 3RD8A 4NSLA 3BHGA 2O78A 3GTDA 2PTSA 5EYVA 1W27A 1VDKA 1YFMA 1U15A 4HGVA 1C3CA 1GKJA 1YISA 1EB4A 1HY1A 2J91A 3KDYA 1HY0A 3R6QA 2VD6A 4FLCA 1JSWA 1Y2MA 4MX2A 1Q5NA
chains in the Genus database with same CATH superfamily
4EEIA 1FUOA 2VUMA 4APBA 1AUWA 1XL8A 2K3OA 4CEIA 3R6VA 1YNND 4CEJA 1DCNA 2PFMA 3CZOA 2FIPA 2VL7A 2F5JA 1SFOA 1J3UA 4C6GA 3GTMA 1TJVA 1XWOA 5H8WA 3H0GA 2PTQA 5D6BA 2HVGA 2LYIA 2QGAB 3GTGA 2RJRA 4C5RA 3EZAA 3GTOA 2O6YA 2FUSA 1GKMA 3NZ4A 2NYFA 2O7DA 3NO9A 2YU9A 1XMCA 4QIWA 2B63A 2O7EA 2RJSA 3C8TA 2A6HD 2O5JD 4C2MA 4BAAA 3QBPA 2HWGA 2CW0D 2O7FA 1B8FA 3FKIA 5EYTA 2Y0NA 2YIIA 2NVYA 1I50A 2X0QA 5M0IA 3KDZA 2LKMB 2NYNA 3GZHA 1TWGA 3LRDA 2E9FA 5F91A 1Y1VA 1I6VD 4CQ5A 2OHYA 2R93A 2EZAA 1I3QA 2EZCA 2E2IA 5IZ2A 3OCFA 5HW2A 1C3UA 1ZYMA 2K3NA 1T6JA 2VK9A 3LR8A 1GK3A 5F92A 3EZEA 2N1DB 1RE5A 2EZBA 2N3EA 1K7WA 4ADMA 4ADLA 3RRPA 1IW7D 2JA6A 1FUPA 1XMDA 1TWFA 3U44A 1YFEA 3CRW1 2E2HA 3TV2A 1TWHA 3UNVA 2AQLA 2MX8A 1SMYD 4C5UA 1Y1WA 1YNJD 3CQZA 3E04A 2QVEA 3U4QA 3GTKA 1FURA 3EZBA 1GK2A 2HROA 1DOFA 3GTLA 1T6PA 4BABA 2FIOA 1I0AA 2X75A 4APAA 2LPIA 2JA7A 2A68D 3LR6A 4EFCA 1TJUA 1TJWA 4C5SA 2R7ZA 1FUQA 1XLYA 1K62A 1WCMA 1TJ7A 1R9TA 4FFXA 2O7BA 1K83A 5M0JA 3R6YA 2A6ED 2LTHA 1U16A 4FBSA 3OCEA 1TWCA 2K3QA 4V2QA 1EZBA 2PTRA 2VSFA 2FELA 4V2RA 1KQ7A 1XL7A 2MP0A 4NLEA 2NVXA 3RD8A 4NSLA 3BHGA 1HQMD 3GTJA 2O78A 2X0PA 3GTPA 2JA5A 2X0OA 3CRVA 2LPJA 3GTDA 2PTSA 5EYVA 1W27A 1VDKA 2A69D 4WNLA 4CEHA 2MQAA 2FENA 1TWAA 1U15A 1YFMA 4HGVA 1C3CA 1GKJA 1ZYRD 1EB4A 1YISA 1HY1A 4A15A 1EZAA 2J91A 3GTQA 3KDYA 3LR2A 1HY0A 3R6QA 2VD6A 2MX9A 2R92A 4FLCA 1JSWA 1Y2MA 4MX2A 2BE5D 1Q5NA
chains in the Genus database with same CATH topology
4EEIA 1FUOA 4APBA 1AUWA 3R6VA 1DCNA 2PFMA 3CZOA 1J3UA 4C6GA 1XWOA 1TJVA 2PTQA 5D6BA 2HVGA 2QGAB 2RJRA 4C5RA 2O6YA 2FUSA 1GKMA 3NZ4A 2NYFA 2O7DA 3NO9A 2O7EA 2RJSA 3C8TA 3QBPA 4BAAA 2O7FA 5EYTA 1B8FA 2YIIA 3KDZA 2NYNA 3GZHA 5F91A 2E9FA 2OHYA 4CQ5A 3OCFA 5HW2A 1C3UA 1T6JA 1GK3A 5F92A 1RE5A 1K7WA 4ADMA 4ADLA 3RRPA 1YFEA 1FUPA 3TV2A 3UNVA 4C5UA 3E04A 2QVEA 1GK2A 1FURA 1DOFA 4BABA 1T6PA 1I0AA 2X75A 4APAA 4EFCA 1TJUA 1TJWA 4C5SA 1FUQA 1K62A 1TJ7A 4FFXA 2O7BA 3R6YA 1U16A 3OCEA 4V2QA 2PTRA 4V2RA 1KQ7A 4NLEA 3RD8A 4NSLA 3BHGA 2O78A 3GTDA 2PTSA 5EYVA 1W27A 1VDKA 1YFMA 1U15A 4HGVA 1C3CA 1GKJA 1YISA 1EB4A 1HY1A 2J91A 3KDYA 1HY0A 3R6QA 2VD6A 4FLCA 1JSWA 1Y2MA 4MX2A 1Q5NA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EEI A;  1FUO A;  4APB A;  1AUW A;  3R6V A;  1DCN A;  2PFM A;  3CZO A;  1J3U A;  4C6G A;  1XWO A;  1TJV A;  2PTQ A;  5D6B A;  2HVG A;  2QGA B;  2RJR A;  4C5R A;  2O6Y A;  2FUS A;  1GKM A;  3NZ4 A;  2NYF A;  2O7D A;  3NO9 A;  2O7E A;  2RJS A;  3C8T A;  3QBP A;  4BAA A;  2O7F A;  5EYT A;  1B8F A;  2YII A;  3KDZ A;  2NYN A;  3GZH A;  5F91 A;  2E9F A;  2OHY A;  4CQ5 A;  3OCF A;  5HW2 A;  1C3U A;  1T6J A;  1GK3 A;  5F92 A;  1RE5 A;  1K7W A;  4ADM A;  4ADL A;  3RRP A;  1YFE A;  1FUP A;  3TV2 A;  3UNV A;  4C5U A;  3E04 A;  2QVE A;  1GK2 A;  1FUR A;  1DOF A;  4BAB A;  1T6P A;  1I0A A;  2X75 A;  4APA A;  4EFC A;  1TJU A;  1TJW A;  4C5S A;  1FUQ A;  1K62 A;  1TJ7 A;  4FFX A;  2O7B A;  3R6Y A;  1U16 A;  3OCE A;  4V2Q A;  2PTR A;  4V2R A;  1KQ7 A;  4NLE A;  3RD8 A;  4NSL A;  3BHG A;  2O78 A;  3GTD A;  2PTS A;  5EYV A;  1W27 A;  1VDK A;  1YFM A;  1U15 A;  4HGV A;  1C3C A;  1GKJ A;  1YIS A;  1EB4 A;  1HY1 A;  2J91 A;  3KDY A;  1HY0 A;  3R6Q A;  2VD6 A;  4FLC A;  1JSW A;  1Y2M A;  4MX2 A;  1Q5N A; 
#chains in the Genus database with same CATH topology
 4EEI A;  1FUO A;  2VUM A;  4APB A;  1AUW A;  1XL8 A;  2K3O A;  4CEI A;  3R6V A;  1YNN D;  4CEJ A;  1DCN A;  2PFM A;  3CZO A;  2FIP A;  2VL7 A;  2F5J A;  1SFO A;  1J3U A;  4C6G A;  3GTM A;  1TJV A;  1XWO A;  5H8W A;  3H0G A;  2PTQ A;  5D6B A;  2HVG A;  2LYI A;  2QGA B;  3GTG A;  2RJR A;  4C5R A;  3EZA A;  3GTO A;  2O6Y A;  2FUS A;  1GKM A;  3NZ4 A;  2NYF A;  2O7D A;  3NO9 A;  2YU9 A;  1XMC A;  4QIW A;  2B63 A;  2O7E A;  2RJS A;  3C8T A;  2A6H D;  2O5J D;  4C2M A;  4BAA A;  3QBP A;  2HWG A;  2CW0 D;  2O7F A;  1B8F A;  3FKI A;  5EYT A;  2Y0N A;  2YII A;  2NVY A;  1I50 A;  2X0Q A;  5M0I A;  3KDZ A;  2LKM B;  2NYN A;  3GZH A;  1TWG A;  3LRD A;  2E9F A;  5F91 A;  1Y1V A;  1I6V D;  4CQ5 A;  2OHY A;  2R93 A;  2EZA A;  1I3Q A;  2EZC A;  2E2I A;  5IZ2 A;  3OCF A;  5HW2 A;  1C3U A;  1ZYM A;  2K3N A;  1T6J A;  2VK9 A;  3LR8 A;  1GK3 A;  5F92 A;  3EZE A;  2N1D B;  1RE5 A;  2EZB A;  2N3E A;  1K7W A;  4ADM A;  4ADL A;  3RRP A;  1IW7 D;  2JA6 A;  1FUP A;  1XMD A;  1TWF A;  3U44 A;  1YFE A;  3CRW 1;  2E2H A;  3TV2 A;  1TWH A;  3UNV A;  2AQL A;  2MX8 A;  1SMY D;  4C5U A;  1Y1W A;  1YNJ D;  3CQZ A;  3E04 A;  2QVE A;  3U4Q A;  3GTK A;  1FUR A;  3EZB A;  1GK2 A;  2HRO A;  1DOF A;  3GTL A;  1T6P A;  4BAB A;  2FIO A;  1I0A A;  2X75 A;  4APA A;  2LPI A;  2JA7 A;  2A68 D;  3LR6 A;  4EFC A;  1TJU A;  1TJW A;  4C5S A;  2R7Z A;  1FUQ A;  1XLY A;  1K62 A;  1WCM A;  1TJ7 A;  1R9T A;  4FFX A;  2O7B A;  1K83 A;  5M0J A;  3R6Y A;  2A6E D;  2LTH A;  1U16 A;  4FBS A;  3OCE A;  1TWC A;  2K3Q A;  4V2Q A;  1EZB A;  2PTR A;  2VSF A;  2FEL A;  4V2R A;  1KQ7 A;  1XL7 A;  2MP0 A;  4NLE A;  2NVX A;  3RD8 A;  4NSL A;  3BHG A;  1HQM D;  3GTJ A;  2O78 A;  2X0P A;  3GTP A;  2JA5 A;  2X0O A;  3CRV A;  2LPJ A;  3GTD A;  2PTS A;  5EYV A;  1W27 A;  1VDK A;  2A69 D;  4WNL A;  4CEH A;  2MQA A;  2FEN A;  1TWA A;  1U15 A;  1YFM A;  4HGV A;  1C3C A;  1GKJ A;  1ZYR D;  1EB4 A;  1YIS A;  1HY1 A;  4A15 A;  1EZA A;  2J91 A;  3GTQ A;  3KDY A;  3LR2 A;  1HY0 A;  3R6Q A;  2VD6 A;  2MX9 A;  2R92 A;  4FLC A;  1JSW A;  1Y2M A;  4MX2 A;  2BE5 D;  1Q5N A; 
#chains in the Genus database with same CATH homology
 4EEI A;  1FUO A;  4APB A;  1AUW A;  3R6V A;  1DCN A;  2PFM A;  3CZO A;  1J3U A;  4C6G A;  1XWO A;  1TJV A;  2PTQ A;  5D6B A;  2HVG A;  2QGA B;  2RJR A;  4C5R A;  2O6Y A;  2FUS A;  1GKM A;  3NZ4 A;  2NYF A;  2O7D A;  3NO9 A;  2O7E A;  2RJS A;  3C8T A;  3QBP A;  4BAA A;  2O7F A;  5EYT A;  1B8F A;  2YII A;  3KDZ A;  2NYN A;  3GZH A;  5F91 A;  2E9F A;  2OHY A;  4CQ5 A;  3OCF A;  5HW2 A;  1C3U A;  1T6J A;  1GK3 A;  5F92 A;  1RE5 A;  1K7W A;  4ADM A;  4ADL A;  3RRP A;  1YFE A;  1FUP A;  3TV2 A;  3UNV A;  4C5U A;  3E04 A;  2QVE A;  1GK2 A;  1FUR A;  1DOF A;  4BAB A;  1T6P A;  1I0A A;  2X75 A;  4APA A;  4EFC A;  1TJU A;  1TJW A;  4C5S A;  1FUQ A;  1K62 A;  1TJ7 A;  4FFX A;  2O7B A;  3R6Y A;  1U16 A;  3OCE A;  4V2Q A;  2PTR A;  4V2R A;  1KQ7 A;  4NLE A;  3RD8 A;  4NSL A;  3BHG A;  2O78 A;  3GTD A;  2PTS A;  5EYV A;  1W27 A;  1VDK A;  1YFM A;  1U15 A;  4HGV A;  1C3C A;  1GKJ A;  1YIS A;  1EB4 A;  1HY1 A;  2J91 A;  3KDY A;  1HY0 A;  3R6Q A;  2VD6 A;  4FLC A;  1JSW A;  1Y2M A;  4MX2 A;  1Q5N A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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