4CQ5A

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 268
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
268
sequence length
667
structure length
638
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIAGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTLPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
molecule keywords PHENYLALANINE AMINOMUTASE
total genus 268
structure length 638
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2014-02-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4cq5A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4cq5A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4cq5A02
2O7EA 1T6JA 4ADMA 3R6YA 2PTSA 1GKJA 3UNVA 2OHYA 4NSLA 1RE5A 3C8TA 4BABA 1J3UA 2PFMA 1AUWA 1JSWA 3KDYA 5F92A 2O7BA 2X75A 3RRPA 1FURA 1DCNA 3CZOA 1FUOA 1GK3A 4APBA 4BAAA 3RD8A 1Y2MA 1FUPA 2O78A 2O7DA 3R6VA 2RJSA 2PTQA 4EFCA 3KDZA 5D6BA 3R6QA 1I0AA 2J91A 2O7FA 3OCEA 4ADLA 3TV2A 3QBPA 4HGVA 1K62A 1TJWA 1YFEA 3OCFA 4EEIA 1W27A 2VD6A 5F91A 2HVGA 4C5UA 1U16A 1YISA 1VDKA 3NO9A 1C3CA 2E9FA 2QVEA 2QGAB 1DOFA 1T6PA 4C6GA 4FLCA 1TJ7A 1K7WA 1GK2A 5EYTA 5HW2A 1FUQA 1U15A 4V2QA 3E04A 2NYNA 4FFXA 2YIIA 1EB4A 4C5RA 1TJUA 4CQ5A 4MX2A 4C5SA 5EYVA 1HY1A 1B8FA 1Q5NA 1HY0A 1YFMA 2RJRA 4V2RA 2NYFA 1GKMA 2O6YA 3BHGA 1KQ7A 3NZ4A 1C3UA 3GTDA 4APAA 2FUSA 1TJVA 2PTRA 1XWOA 4NLEA 3GZHA
chains in the Genus database with same CATH superfamily
2A6HD 2O7EA 1T6JA 1TWGA 4C2MA 3CRW1 4ADMA 3R6YA 2NVXA 2PTSA 1GKJA 2JA6A 3UNVA 2OHYA 4QIWA 2K3OA 4NSLA 1RE5A 4CEHA 3C8TA 1ZYRD 4BABA 2LPIA 1ZYMA 1J3UA 2VUMA 1AUWA 2PFMA 3LR2A 1JSWA 3EZBA 3KDYA 2EZAA 2MX8A 5F92A 2JA5A 1HQMD 2MX9A 4CEJA 2EZBA 2FIOA 2O7BA 2X75A 1XMCA 1EZAA 3RRPA 1FURA 2B63A 1DCNA 3CZOA 1FUOA 2LTHA 1TWCA 1GK3A 3GTJA 4APBA 4BAAA 2O5JD 2HWGA 2NVYA 3RD8A 1Y2MA 2VL7A 3GTOA 1FUPA 2O78A 2X0PA 2O7DA 3R6VA 2RJSA 2PTQA 2VSFA 4EFCA 3KDZA 5D6BA 3R6QA 3H0GA 2A68D 2Y0NA 1I0AA 1SFOA 2J91A 2O7FA 2MQAA 1XMDA 3OCEA 2YU9A 3TV2A 4CEIA 3LR6A 3QBPA 4HGVA 1K62A 1XLYA 2LYIA 1TJWA 3U4QA 1WCMA 1YFEA 4WNLA 2A69D 3U44A 3OCFA 2R93A 1W27A 4EEIA 2VD6A 4A15A 5F91A 2HVGA 4C5UA 2VK9A 3GTGA 1U16A 1VDKA 1YISA 3GTLA 2R7ZA 4ADLA 3NO9A 1TWAA 1C3CA 2E9FA 3GTKA 5H8WA 2QVEA 3FKIA 1I50A 2QGAB 1TWHA 1DOFA 1T6PA 3CRVA 2X0OA 1YNND 4C6GA 4FLCA 2K3NA 2K3QA 1TJ7A 1K7WA 2LKMB 1GK2A 5EYTA 5HW2A 3GTMA 2LPJA 1Y1WA 1FUQA 2HROA 2AQLA 1U15A 2E2HA 4V2QA 3E04A 2NYNA 3CQZA 4FFXA 2YIIA 1I3QA 1EB4A 4C5RA 5M0IA 5IZ2A 1SMYD 1IW7D 1TJUA 1EZBA 2A6ED 4CQ5A 4MX2A 4C5SA 2FENA 2FELA 2R92A 3GTQA 3EZEA 3GTPA 5EYVA 2JA7A 1HY1A 3EZAA 1B8FA 1TWFA 1Q5NA 1HY0A 1YFMA 1Y1VA 2RJRA 4V2RA 2E2IA 2NYFA 2N3EA 4FBSA 1GKMA 2CW0D 2EZCA 1YNJD 1K83A 2O6YA 3BHGA 1R9TA 1XL8A 1KQ7A 3NZ4A 2FIPA 1C3UA 3GTDA 4APAA 5M0JA 1XL7A 2N1DB 2F5JA 2FUSA 2MP0A 2BE5D 3LR8A 3LRDA 2X0QA 1TJVA 1XWOA 2PTRA 1I6VD 4NLEA 3GZHA
chains in the Genus database with same CATH topology
2O7EA 1T6JA 4ADMA 3R6YA 2PTSA 1GKJA 3UNVA 2OHYA 4NSLA 1RE5A 3C8TA 4BABA 1J3UA 2PFMA 1AUWA 1JSWA 3KDYA 5F92A 2O7BA 2X75A 3RRPA 1FURA 1DCNA 3CZOA 1FUOA 1GK3A 4APBA 4BAAA 3RD8A 1Y2MA 1FUPA 2O78A 2O7DA 3R6VA 2RJSA 2PTQA 4EFCA 3KDZA 5D6BA 3R6QA 1I0AA 2J91A 2O7FA 3OCEA 4ADLA 3TV2A 3QBPA 4HGVA 1K62A 1TJWA 1YFEA 3OCFA 4EEIA 1W27A 2VD6A 5F91A 2HVGA 4C5UA 1U16A 1YISA 1VDKA 3NO9A 1C3CA 2E9FA 2QVEA 2QGAB 1DOFA 1T6PA 4C6GA 4FLCA 1TJ7A 1K7WA 1GK2A 5EYTA 5HW2A 1FUQA 1U15A 4V2QA 3E04A 2NYNA 4FFXA 2YIIA 1EB4A 4C5RA 1TJUA 4CQ5A 4MX2A 4C5SA 5EYVA 1HY1A 1B8FA 1Q5NA 1HY0A 1YFMA 2RJRA 4V2RA 2NYFA 1GKMA 2O6YA 3BHGA 1KQ7A 3NZ4A 1C3UA 3GTDA 4APAA 2FUSA 1TJVA 2PTRA 1XWOA 4NLEA 3GZHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2O7E A;  1T6J A;  4ADM A;  3R6Y A;  2PTS A;  1GKJ A;  3UNV A;  2OHY A;  4NSL A;  1RE5 A;  3C8T A;  4BAB A;  1J3U A;  2PFM A;  1AUW A;  1JSW A;  3KDY A;  5F92 A;  2O7B A;  2X75 A;  3RRP A;  1FUR A;  1DCN A;  3CZO A;  1FUO A;  1GK3 A;  4APB A;  4BAA A;  3RD8 A;  1Y2M A;  1FUP A;  2O78 A;  2O7D A;  3R6V A;  2RJS A;  2PTQ A;  4EFC A;  3KDZ A;  5D6B A;  3R6Q A;  1I0A A;  2J91 A;  2O7F A;  3OCE A;  4ADL A;  3TV2 A;  3QBP A;  4HGV A;  1K62 A;  1TJW A;  1YFE A;  3OCF A;  4EEI A;  1W27 A;  2VD6 A;  5F91 A;  2HVG A;  4C5U A;  1U16 A;  1YIS A;  1VDK A;  3NO9 A;  1C3C A;  2E9F A;  2QVE A;  2QGA B;  1DOF A;  1T6P A;  4C6G A;  4FLC A;  1TJ7 A;  1K7W A;  1GK2 A;  5EYT A;  5HW2 A;  1FUQ A;  1U15 A;  4V2Q A;  3E04 A;  2NYN A;  4FFX A;  2YII A;  1EB4 A;  4C5R A;  1TJU A;  4CQ5 A;  4MX2 A;  4C5S A;  5EYV A;  1HY1 A;  1B8F A;  1Q5N A;  1HY0 A;  1YFM A;  2RJR A;  4V2R A;  2NYF A;  1GKM A;  2O6Y A;  3BHG A;  1KQ7 A;  3NZ4 A;  1C3U A;  3GTD A;  4APA A;  2FUS A;  1TJV A;  2PTR A;  1XWO A;  4NLE A;  3GZH A; 
#chains in the Genus database with same CATH topology
 2A6H D;  2O7E A;  1T6J A;  1TWG A;  4C2M A;  3CRW 1;  4ADM A;  3R6Y A;  2NVX A;  2PTS A;  1GKJ A;  2JA6 A;  3UNV A;  2OHY A;  4QIW A;  2K3O A;  4NSL A;  1RE5 A;  4CEH A;  3C8T A;  1ZYR D;  4BAB A;  2LPI A;  1ZYM A;  1J3U A;  2VUM A;  1AUW A;  2PFM A;  3LR2 A;  1JSW A;  3EZB A;  3KDY A;  2EZA A;  2MX8 A;  5F92 A;  2JA5 A;  1HQM D;  2MX9 A;  4CEJ A;  2EZB A;  2FIO A;  2O7B A;  2X75 A;  1XMC A;  1EZA A;  3RRP A;  1FUR A;  2B63 A;  1DCN A;  3CZO A;  1FUO A;  2LTH A;  1TWC A;  1GK3 A;  3GTJ A;  4APB A;  4BAA A;  2O5J D;  2HWG A;  2NVY A;  3RD8 A;  1Y2M A;  2VL7 A;  3GTO A;  1FUP A;  2O78 A;  2X0P A;  2O7D A;  3R6V A;  2RJS A;  2PTQ A;  2VSF A;  4EFC A;  3KDZ A;  5D6B A;  3R6Q A;  3H0G A;  2A68 D;  2Y0N A;  1I0A A;  1SFO A;  2J91 A;  2O7F A;  2MQA A;  1XMD A;  3OCE A;  2YU9 A;  3TV2 A;  4CEI A;  3LR6 A;  3QBP A;  4HGV A;  1K62 A;  1XLY A;  2LYI A;  1TJW A;  3U4Q A;  1WCM A;  1YFE A;  4WNL A;  2A69 D;  3U44 A;  3OCF A;  2R93 A;  1W27 A;  4EEI A;  2VD6 A;  4A15 A;  5F91 A;  2HVG A;  4C5U A;  2VK9 A;  3GTG A;  1U16 A;  1VDK A;  1YIS A;  3GTL A;  2R7Z A;  4ADL A;  3NO9 A;  1TWA A;  1C3C A;  2E9F A;  3GTK A;  5H8W A;  2QVE A;  3FKI A;  1I50 A;  2QGA B;  1TWH A;  1DOF A;  1T6P A;  3CRV A;  2X0O A;  1YNN D;  4C6G A;  4FLC A;  2K3N A;  2K3Q A;  1TJ7 A;  1K7W A;  2LKM B;  1GK2 A;  5EYT A;  5HW2 A;  3GTM A;  2LPJ A;  1Y1W A;  1FUQ A;  2HRO A;  2AQL A;  1U15 A;  2E2H A;  4V2Q A;  3E04 A;  2NYN A;  3CQZ A;  4FFX A;  2YII A;  1I3Q A;  1EB4 A;  4C5R A;  5M0I A;  5IZ2 A;  1SMY D;  1IW7 D;  1TJU A;  1EZB A;  2A6E D;  4CQ5 A;  4MX2 A;  4C5S A;  2FEN A;  2FEL A;  2R92 A;  3GTQ A;  3EZE A;  3GTP A;  5EYV A;  2JA7 A;  1HY1 A;  3EZA A;  1B8F A;  1TWF A;  1Q5N A;  1HY0 A;  1YFM A;  1Y1V A;  2RJR A;  4V2R A;  2E2I A;  2NYF A;  2N3E A;  4FBS A;  1GKM A;  2CW0 D;  2EZC A;  1YNJ D;  1K83 A;  2O6Y A;  3BHG A;  1R9T A;  1XL8 A;  1KQ7 A;  3NZ4 A;  2FIP A;  1C3U A;  3GTD A;  4APA A;  5M0J A;  1XL7 A;  2N1D B;  2F5J A;  2FUS A;  2MP0 A;  2BE5 D;  3LR8 A;  3LRD A;  2X0Q A;  1TJV A;  1XWO A;  2PTR A;  1I6V D;  4NLE A;  3GZH A; 
#chains in the Genus database with same CATH homology
 2O7E A;  1T6J A;  4ADM A;  3R6Y A;  2PTS A;  1GKJ A;  3UNV A;  2OHY A;  4NSL A;  1RE5 A;  3C8T A;  4BAB A;  1J3U A;  2PFM A;  1AUW A;  1JSW A;  3KDY A;  5F92 A;  2O7B A;  2X75 A;  3RRP A;  1FUR A;  1DCN A;  3CZO A;  1FUO A;  1GK3 A;  4APB A;  4BAA A;  3RD8 A;  1Y2M A;  1FUP A;  2O78 A;  2O7D A;  3R6V A;  2RJS A;  2PTQ A;  4EFC A;  3KDZ A;  5D6B A;  3R6Q A;  1I0A A;  2J91 A;  2O7F A;  3OCE A;  4ADL A;  3TV2 A;  3QBP A;  4HGV A;  1K62 A;  1TJW A;  1YFE A;  3OCF A;  4EEI A;  1W27 A;  2VD6 A;  5F91 A;  2HVG A;  4C5U A;  1U16 A;  1YIS A;  1VDK A;  3NO9 A;  1C3C A;  2E9F A;  2QVE A;  2QGA B;  1DOF A;  1T6P A;  4C6G A;  4FLC A;  1TJ7 A;  1K7W A;  1GK2 A;  5EYT A;  5HW2 A;  1FUQ A;  1U15 A;  4V2Q A;  3E04 A;  2NYN A;  4FFX A;  2YII A;  1EB4 A;  4C5R A;  1TJU A;  4CQ5 A;  4MX2 A;  4C5S A;  5EYV A;  1HY1 A;  1B8F A;  1Q5N A;  1HY0 A;  1YFM A;  2RJR A;  4V2R A;  2NYF A;  1GKM A;  2O6Y A;  3BHG A;  1KQ7 A;  3NZ4 A;  1C3U A;  3GTD A;  4APA A;  2FUS A;  1TJV A;  2PTR A;  1XWO A;  4NLE A;  3GZH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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