4CQ5A

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 268
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
268
sequence length
667
structure length
638
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIAGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTLPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Lyase
molecule keywords PHENYLALANINE AMINOMUTASE
publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
total genus 268
structure length 638
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2014-02-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4cq5A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4cq5A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4cq5A02
4APBA 3NO9A 2RJSA 4NLEA 4EFCA 2PTRA 3TV2A 1C3CA 1TJ7A 2NYNA 2NYFA 1W27A 3QBPA 4NSLA 4C5UA 1GKJA 1T6JA 1T6PA 4HGVA 1VDKA 1DOFA 2X75A 4V2QA 1EB4A 1Q5NA 1C3UA 4BAAA 4CQ5A 3R6QA 2QGAB 2OHYA 1TJUA 4C5RA 1J3UA 2PTQA 2O7FA 3CZOA 1FUOA 1DCNA 1K7WA 4FLCA 5F92A 1AUWA 2O7EA 5D6BA 2E9FA 4BABA 3KDYA 1HY0A 4C5SA 3RRPA 2O7BA 2PTSA 1KQ7A 5F91A 1JSWA 1YISA 3C8TA 4APAA 3R6YA 3GTDA 2YIIA 3RD8A 1FUQA 1GK3A 1FUPA 1B8FA 1K62A 3BHGA 3NZ4A 1I0AA 3GZHA 2FUSA 5EYTA 3UNVA 4EEIA 1GKMA 1YFMA 4V2RA 4ADMA 1Y2MA 2PFMA 4ADLA 5HW2A 1FURA 4FFXA 1RE5A 4C6GA 1U15A 2J91A 2O7DA 2VD6A 1U16A 2O78A 2RJRA 5EYVA 2O6YA 4MX2A 1HY1A 3OCEA 1GK2A 1TJWA 2HVGA 3OCFA 1XWOA 3R6VA 1TJVA 2QVEA 3KDZA 3E04A 1YFEA
chains in the Genus database with same CATH superfamily
4APBA 2K3QA 1K83A 3NO9A 2RJSA 4NLEA 3CRVA 1TWAA 2PTRA 1HQMD 3TV2A 4EFCA 4A15A 2FIOA 1C3CA 1TJ7A 2MX8A 4QIWA 2YU9A 2NYNA 1SFOA 2JA5A 1XMCA 2NYFA 2R93A 1W27A 3QBPA 4NSLA 4C5UA 2K3NA 1GKJA 1T6JA 1T6PA 4HGVA 1VDKA 2LPIA 1DOFA 2X75A 4V2QA 1EB4A 1TWFA 1Q5NA 2FENA 3EZBA 1C3UA 4BAAA 1Y1VA 4CQ5A 2EZCA 1TWHA 2LYIA 1ZYMA 3R6QA 5IZ2A 3GTKA 1YNND 2QGAB 1I50A 2EZAA 1R9TA 4CEJA 2OHYA 1XLYA 2HROA 2A6ED 1TJUA 4C5RA 1J3UA 2PTQA 3LR2A 3GTQA 1IW7D 2O7FA 2BE5D 2E2HA 2VSFA 3CZOA 1FUOA 1DCNA 1K7WA 5M0IA 3H0GA 4FLCA 3LR8A 3GTMA 5F92A 1AUWA 2O7EA 5D6BA 2E9FA 4BABA 3KDYA 1HY0A 2A69D 4C5SA 3EZEA 2VK9A 3RRPA 2O7BA 3LR6A 2HWGA 1WCMA 3CQZA 2PTSA 1KQ7A 5F91A 2AQLA 1JSWA 2FELA 2CW0D 2MX9A 2JA6A 1YISA 3C8TA 2MP0A 1TWCA 1XL8A 2VL7A 1ZYRD 2A6HD 2R92A 4APAA 1I3QA 3R6YA 4CEIA 2O5JD 3GTLA 3GTDA 1YNJD 3FKIA 2YIIA 3RD8A 3GTGA 2NVXA 1FUQA 2NVYA 1FUPA 1GK3A 2LPJA 1B8FA 1K62A 3BHGA 3NZ4A 2N3EA 2K3OA 5H8WA 1I0AA 1TWGA 2FUSA 3GZHA 5EYTA 3UNVA 4EEIA 1GKMA 1YFMA 4V2RA 4ADMA 1Y2MA 2X0QA 2A68D 3GTJA 2B63A 2PFMA 4ADLA 5HW2A 2EZBA 3U4QA 2VUMA 1FURA 4FFXA 2Y0NA 1RE5A 4C6GA 3EZAA 1U15A 2J91A 2JA7A 2O7DA 2X0PA 1I6VD 2LTHA 2VD6A 1U16A 2O78A 2RJRA 1EZBA 2FIPA 5EYVA 2O6YA 2F5JA 2X0OA 4MX2A 1HY1A 4WNLA 2E2IA 4C2MA 3GTPA 3U44A 3OCEA 1GK2A 1TJWA 3CRW1 2HVGA 3OCFA 2MQAA 1Y1WA 2R7ZA 1XWOA 2LKMB 3R6VA 1XMDA 1SMYD 2N1DB 1TJVA 3LRDA 5M0JA 4CEHA 1XL7A 2QVEA 3GTOA 1EZAA 3KDZA 4FBSA 3E04A 1YFEA
chains in the Genus database with same CATH topology
4APBA 3NO9A 2RJSA 4NLEA 4EFCA 2PTRA 3TV2A 1C3CA 1TJ7A 2NYNA 2NYFA 1W27A 3QBPA 4NSLA 4C5UA 1GKJA 1T6JA 1T6PA 4HGVA 1VDKA 1DOFA 2X75A 4V2QA 1EB4A 1Q5NA 1C3UA 4BAAA 4CQ5A 3R6QA 2QGAB 2OHYA 1TJUA 4C5RA 1J3UA 2PTQA 2O7FA 3CZOA 1FUOA 1DCNA 1K7WA 4FLCA 5F92A 1AUWA 2O7EA 5D6BA 2E9FA 4BABA 3KDYA 1HY0A 4C5SA 3RRPA 2O7BA 2PTSA 1KQ7A 5F91A 1JSWA 1YISA 3C8TA 4APAA 3R6YA 3GTDA 2YIIA 3RD8A 1FUQA 1GK3A 1FUPA 1B8FA 1K62A 3BHGA 3NZ4A 1I0AA 3GZHA 2FUSA 5EYTA 3UNVA 4EEIA 1GKMA 1YFMA 4V2RA 4ADMA 1Y2MA 2PFMA 4ADLA 5HW2A 1FURA 4FFXA 1RE5A 4C6GA 1U15A 2J91A 2O7DA 2VD6A 1U16A 2O78A 2RJRA 5EYVA 2O6YA 4MX2A 1HY1A 3OCEA 1GK2A 1TJWA 2HVGA 3OCFA 1XWOA 3R6VA 1TJVA 2QVEA 3KDZA 3E04A 1YFEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4APB A;  3NO9 A;  2RJS A;  4NLE A;  4EFC A;  2PTR A;  3TV2 A;  1C3C A;  1TJ7 A;  2NYN A;  2NYF A;  1W27 A;  3QBP A;  4NSL A;  4C5U A;  1GKJ A;  1T6J A;  1T6P A;  4HGV A;  1VDK A;  1DOF A;  2X75 A;  4V2Q A;  1EB4 A;  1Q5N A;  1C3U A;  4BAA A;  4CQ5 A;  3R6Q A;  2QGA B;  2OHY A;  1TJU A;  4C5R A;  1J3U A;  2PTQ A;  2O7F A;  3CZO A;  1FUO A;  1DCN A;  1K7W A;  4FLC A;  5F92 A;  1AUW A;  2O7E A;  5D6B A;  2E9F A;  4BAB A;  3KDY A;  1HY0 A;  4C5S A;  3RRP A;  2O7B A;  2PTS A;  1KQ7 A;  5F91 A;  1JSW A;  1YIS A;  3C8T A;  4APA A;  3R6Y A;  3GTD A;  2YII A;  3RD8 A;  1FUQ A;  1GK3 A;  1FUP A;  1B8F A;  1K62 A;  3BHG A;  3NZ4 A;  1I0A A;  3GZH A;  2FUS A;  5EYT A;  3UNV A;  4EEI A;  1GKM A;  1YFM A;  4V2R A;  4ADM A;  1Y2M A;  2PFM A;  4ADL A;  5HW2 A;  1FUR A;  4FFX A;  1RE5 A;  4C6G A;  1U15 A;  2J91 A;  2O7D A;  2VD6 A;  1U16 A;  2O78 A;  2RJR A;  5EYV A;  2O6Y A;  4MX2 A;  1HY1 A;  3OCE A;  1GK2 A;  1TJW A;  2HVG A;  3OCF A;  1XWO A;  3R6V A;  1TJV A;  2QVE A;  3KDZ A;  3E04 A;  1YFE A; 
#chains in the Genus database with same CATH topology
 4APB A;  2K3Q A;  1K83 A;  3NO9 A;  2RJS A;  4NLE A;  3CRV A;  1TWA A;  2PTR A;  1HQM D;  3TV2 A;  4EFC A;  4A15 A;  2FIO A;  1C3C A;  1TJ7 A;  2MX8 A;  4QIW A;  2YU9 A;  2NYN A;  1SFO A;  2JA5 A;  1XMC A;  2NYF A;  2R93 A;  1W27 A;  3QBP A;  4NSL A;  4C5U A;  2K3N A;  1GKJ A;  1T6J A;  1T6P A;  4HGV A;  1VDK A;  2LPI A;  1DOF A;  2X75 A;  4V2Q A;  1EB4 A;  1TWF A;  1Q5N A;  2FEN A;  3EZB A;  1C3U A;  4BAA A;  1Y1V A;  4CQ5 A;  2EZC A;  1TWH A;  2LYI A;  1ZYM A;  3R6Q A;  5IZ2 A;  3GTK A;  1YNN D;  2QGA B;  1I50 A;  2EZA A;  1R9T A;  4CEJ A;  2OHY A;  1XLY A;  2HRO A;  2A6E D;  1TJU A;  4C5R A;  1J3U A;  2PTQ A;  3LR2 A;  3GTQ A;  1IW7 D;  2O7F A;  2BE5 D;  2E2H A;  2VSF A;  3CZO A;  1FUO A;  1DCN A;  1K7W A;  5M0I A;  3H0G A;  4FLC A;  3LR8 A;  3GTM A;  5F92 A;  1AUW A;  2O7E A;  5D6B A;  2E9F A;  4BAB A;  3KDY A;  1HY0 A;  2A69 D;  4C5S A;  3EZE A;  2VK9 A;  3RRP A;  2O7B A;  3LR6 A;  2HWG A;  1WCM A;  3CQZ A;  2PTS A;  1KQ7 A;  5F91 A;  2AQL A;  1JSW A;  2FEL A;  2CW0 D;  2MX9 A;  2JA6 A;  1YIS A;  3C8T A;  2MP0 A;  1TWC A;  1XL8 A;  2VL7 A;  1ZYR D;  2A6H D;  2R92 A;  4APA A;  1I3Q A;  3R6Y A;  4CEI A;  2O5J D;  3GTL A;  3GTD A;  1YNJ D;  3FKI A;  2YII A;  3RD8 A;  3GTG A;  2NVX A;  1FUQ A;  2NVY A;  1FUP A;  1GK3 A;  2LPJ A;  1B8F A;  1K62 A;  3BHG A;  3NZ4 A;  2N3E A;  2K3O A;  5H8W A;  1I0A A;  1TWG A;  2FUS A;  3GZH A;  5EYT A;  3UNV A;  4EEI A;  1GKM A;  1YFM A;  4V2R A;  4ADM A;  1Y2M A;  2X0Q A;  2A68 D;  3GTJ A;  2B63 A;  2PFM A;  4ADL A;  5HW2 A;  2EZB A;  3U4Q A;  2VUM A;  1FUR A;  4FFX A;  2Y0N A;  1RE5 A;  4C6G A;  3EZA A;  1U15 A;  2J91 A;  2JA7 A;  2O7D A;  2X0P A;  1I6V D;  2LTH A;  2VD6 A;  1U16 A;  2O78 A;  2RJR A;  1EZB A;  2FIP A;  5EYV A;  2O6Y A;  2F5J A;  2X0O A;  4MX2 A;  1HY1 A;  4WNL A;  2E2I A;  4C2M A;  3GTP A;  3U44 A;  3OCE A;  1GK2 A;  1TJW A;  3CRW 1;  2HVG A;  3OCF A;  2MQA A;  1Y1W A;  2R7Z A;  1XWO A;  2LKM B;  3R6V A;  1XMD A;  1SMY D;  2N1D B;  1TJV A;  3LRD A;  5M0J A;  4CEH A;  1XL7 A;  2QVE A;  3GTO A;  1EZA A;  3KDZ A;  4FBS A;  3E04 A;  1YFE A; 
#chains in the Genus database with same CATH homology
 4APB A;  3NO9 A;  2RJS A;  4NLE A;  4EFC A;  2PTR A;  3TV2 A;  1C3C A;  1TJ7 A;  2NYN A;  2NYF A;  1W27 A;  3QBP A;  4NSL A;  4C5U A;  1GKJ A;  1T6J A;  1T6P A;  4HGV A;  1VDK A;  1DOF A;  2X75 A;  4V2Q A;  1EB4 A;  1Q5N A;  1C3U A;  4BAA A;  4CQ5 A;  3R6Q A;  2QGA B;  2OHY A;  1TJU A;  4C5R A;  1J3U A;  2PTQ A;  2O7F A;  3CZO A;  1FUO A;  1DCN A;  1K7W A;  4FLC A;  5F92 A;  1AUW A;  2O7E A;  5D6B A;  2E9F A;  4BAB A;  3KDY A;  1HY0 A;  4C5S A;  3RRP A;  2O7B A;  2PTS A;  1KQ7 A;  5F91 A;  1JSW A;  1YIS A;  3C8T A;  4APA A;  3R6Y A;  3GTD A;  2YII A;  3RD8 A;  1FUQ A;  1GK3 A;  1FUP A;  1B8F A;  1K62 A;  3BHG A;  3NZ4 A;  1I0A A;  3GZH A;  2FUS A;  5EYT A;  3UNV A;  4EEI A;  1GKM A;  1YFM A;  4V2R A;  4ADM A;  1Y2M A;  2PFM A;  4ADL A;  5HW2 A;  1FUR A;  4FFX A;  1RE5 A;  4C6G A;  1U15 A;  2J91 A;  2O7D A;  2VD6 A;  1U16 A;  2O78 A;  2RJR A;  5EYV A;  2O6Y A;  4MX2 A;  1HY1 A;  3OCE A;  1GK2 A;  1TJW A;  2HVG A;  3OCF A;  1XWO A;  3R6V A;  1TJV A;  2QVE A;  3KDZ A;  3E04 A;  1YFE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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