4CQ5A

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 268
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
268
sequence length
667
structure length
638
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIAGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTLPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMINOMUTASE
publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 268
structure length 638
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2014-02-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4cq5A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4cq5A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4cq5A02
2QVEA 1C3CA 4C5SA 1GK3A 1TJWA 1B8FA 2O7EA 4EFCA 1GK2A 1YFMA 3NZ4A 4BABA 1EB4A 3OCFA 1I0AA 3OCEA 4C5RA 1U16A 2O78A 3RD8A 4V2QA 2PTSA 2PTQA 3R6YA 1K62A 2O7FA 2PTRA 3CZOA 5F92A 1KQ7A 4FLCA 5F91A 2J91A 4NSLA 1DCNA 3R6VA 2X75A 1TJUA 4ADLA 2RJSA 3KDZA 1YISA 2QGAB 4EEIA 4C5UA 1C3UA 4MX2A 3UNVA 2HVGA 1K7WA 3R6QA 1J3UA 1XWOA 1Y2MA 4C6GA 1VDKA 2O6YA 5D6BA 2VD6A 5EYVA 1W27A 2NYNA 1TJVA 1GKJA 2NYFA 1FUPA 2FUSA 3GZHA 1T6PA 2O7BA 3QBPA 1JSWA 4NLEA 1FUOA 1YFEA 1DOFA 4BAAA 1GKMA 3GTDA 3NO9A 1Q5NA 5HW2A 1U15A 1HY1A 3TV2A 3BHGA 2O7DA 1T6JA 2PFMA 1FURA 3RRPA 1TJ7A 4V2RA 3E04A 4APBA 1RE5A 4HGVA 1HY0A 2OHYA 3KDYA 4FFXA 4APAA 1FUQA 4CQ5A 2YIIA 1AUWA 2RJRA 3C8TA 2E9FA 4ADMA 5EYTA
chains in the Genus database with same CATH superfamily
2QVEA 2K3QA 1C3CA 4C5SA 3EZBA 1GK3A 2FIPA 1TJWA 1TWFA 2K3NA 1B8FA 2N1DB 2O7EA 4EFCA 1GK2A 1YFMA 3NZ4A 4BABA 1EB4A 3OCFA 1I0AA 2CW0D 1R9TA 2F5JA 4C5RA 3OCEA 1U16A 2O78A 1TWGA 3RD8A 4V2QA 2PTSA 3CQZA 2PTQA 3R6YA 1K62A 2O7FA 2N3EA 2PTRA 3CZOA 1EZBA 1I3QA 1WCMA 2A68D 2LKMB 1KQ7A 2VL7A 5F92A 2X0OA 4FLCA 5F91A 2J91A 2AQLA 4NSLA 1XL7A 5M0JA 2LYIA 1YNND 2EZBA 1DCNA 2A69D 2A6HD 2NVYA 2NVXA 2BE5D 2MX8A 3LRDA 2O5JD 1TJUA 2X75A 3R6VA 2FELA 1TWHA 2LTHA 4ADLA 1Y1WA 2R93A 3GTGA 3GTKA 2RJSA 2LPJA 4CEHA 3KDZA 2EZAA 4C2MA 3GTQA 2VUMA 1YISA 2QGAB 4EEIA 3LR2A 4C5UA 3FKIA 1C3UA 4MX2A 2VSFA 3UNVA 1XMDA 2MQAA 3GTPA 1HQMD 2LPIA 2HVGA 1K7WA 3R6QA 1J3UA 3LR6A 1XWOA 1Y2MA 3EZAA 4C6GA 2A6ED 1VDKA 2O6YA 1ZYMA 2X0QA 4CEJA 2VD6A 5D6BA 5H8WA 1SMYD 5EYVA 4QIWA 1W27A 1TWCA 2FENA 2NYNA 2JA5A 1TJVA 1YNJD 2R7ZA 4WNLA 4FBSA 3GTMA 2JA6A 1GKJA 2NYFA 1FUPA 3LR8A 2FUSA 3GZHA 1T6PA 2HROA 3GTOA 1JSWA 2O7BA 1FUOA 3QBPA 4NLEA 1I50A 2Y0NA 1DOFA 4CEIA 1I6VD 1YFEA 4BAAA 1TWAA 2E2HA 5IZ2A 1Y1VA 2B63A 1GKMA 3GTDA 3U44A 3NO9A 3H0GA 2EZCA 2VK9A 3GTLA 4ADMA 2MX9A 3U4QA 2R92A 1Q5NA 5HW2A 3EZEA 1U15A 3CRW1 1HY1A 3TV2A 3BHGA 2O7DA 1T6JA 2PFMA 1FURA 3RRPA 1TJ7A 1EZAA 4V2RA 2JA7A 5M0IA 3E04A 1SFOA 4APBA 1RE5A 4HGVA 1XMCA 1XL8A 1K83A 2FIOA 4A15A 1HY0A 3CRVA 2OHYA 3KDYA 2K3OA 4FFXA 1XLYA 4APAA 1FUQA 2E2IA 2YU9A 4CQ5A 2YIIA 1AUWA 1ZYRD 3GTJA 2RJRA 1IW7D 3C8TA 2E9FA 2HWGA 2X0PA 5EYTA 2MP0A
chains in the Genus database with same CATH topology
2QVEA 1C3CA 4C5SA 1GK3A 1TJWA 1B8FA 2O7EA 4EFCA 1GK2A 1YFMA 3NZ4A 4BABA 1EB4A 3OCFA 1I0AA 3OCEA 4C5RA 1U16A 2O78A 3RD8A 4V2QA 2PTSA 2PTQA 3R6YA 1K62A 2O7FA 2PTRA 3CZOA 5F92A 1KQ7A 4FLCA 5F91A 2J91A 4NSLA 1DCNA 3R6VA 2X75A 1TJUA 4ADLA 2RJSA 3KDZA 1YISA 2QGAB 4EEIA 4C5UA 1C3UA 4MX2A 3UNVA 2HVGA 1K7WA 3R6QA 1J3UA 1XWOA 1Y2MA 4C6GA 1VDKA 2O6YA 5D6BA 2VD6A 5EYVA 1W27A 2NYNA 1TJVA 1GKJA 2NYFA 1FUPA 2FUSA 3GZHA 1T6PA 2O7BA 3QBPA 1JSWA 4NLEA 1FUOA 1YFEA 1DOFA 4BAAA 1GKMA 3GTDA 3NO9A 1Q5NA 5HW2A 1U15A 1HY1A 3TV2A 3BHGA 2O7DA 1T6JA 2PFMA 1FURA 3RRPA 1TJ7A 4V2RA 3E04A 4APBA 1RE5A 4HGVA 1HY0A 2OHYA 3KDYA 4FFXA 4APAA 1FUQA 4CQ5A 2YIIA 1AUWA 2RJRA 3C8TA 2E9FA 4ADMA 5EYTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2QVE A;  1C3C A;  4C5S A;  1GK3 A;  1TJW A;  1B8F A;  2O7E A;  4EFC A;  1GK2 A;  1YFM A;  3NZ4 A;  4BAB A;  1EB4 A;  3OCF A;  1I0A A;  3OCE A;  4C5R A;  1U16 A;  2O78 A;  3RD8 A;  4V2Q A;  2PTS A;  2PTQ A;  3R6Y A;  1K62 A;  2O7F A;  2PTR A;  3CZO A;  5F92 A;  1KQ7 A;  4FLC A;  5F91 A;  2J91 A;  4NSL A;  1DCN A;  3R6V A;  2X75 A;  1TJU A;  4ADL A;  2RJS A;  3KDZ A;  1YIS A;  2QGA B;  4EEI A;  4C5U A;  1C3U A;  4MX2 A;  3UNV A;  2HVG A;  1K7W A;  3R6Q A;  1J3U A;  1XWO A;  1Y2M A;  4C6G A;  1VDK A;  2O6Y A;  5D6B A;  2VD6 A;  5EYV A;  1W27 A;  2NYN A;  1TJV A;  1GKJ A;  2NYF A;  1FUP A;  2FUS A;  3GZH A;  1T6P A;  2O7B A;  3QBP A;  1JSW A;  4NLE A;  1FUO A;  1YFE A;  1DOF A;  4BAA A;  1GKM A;  3GTD A;  3NO9 A;  1Q5N A;  5HW2 A;  1U15 A;  1HY1 A;  3TV2 A;  3BHG A;  2O7D A;  1T6J A;  2PFM A;  1FUR A;  3RRP A;  1TJ7 A;  4V2R A;  3E04 A;  4APB A;  1RE5 A;  4HGV A;  1HY0 A;  2OHY A;  3KDY A;  4FFX A;  4APA A;  1FUQ A;  4CQ5 A;  2YII A;  1AUW A;  2RJR A;  3C8T A;  2E9F A;  4ADM A;  5EYT A; 
#chains in the Genus database with same CATH topology
 2QVE A;  2K3Q A;  1C3C A;  4C5S A;  3EZB A;  1GK3 A;  2FIP A;  1TJW A;  1TWF A;  2K3N A;  1B8F A;  2N1D B;  2O7E A;  4EFC A;  1GK2 A;  1YFM A;  3NZ4 A;  4BAB A;  1EB4 A;  3OCF A;  1I0A A;  2CW0 D;  1R9T A;  2F5J A;  4C5R A;  3OCE A;  1U16 A;  2O78 A;  1TWG A;  3RD8 A;  4V2Q A;  2PTS A;  3CQZ A;  2PTQ A;  3R6Y A;  1K62 A;  2O7F A;  2N3E A;  2PTR A;  3CZO A;  1EZB A;  1I3Q A;  1WCM A;  2A68 D;  2LKM B;  1KQ7 A;  2VL7 A;  5F92 A;  2X0O A;  4FLC A;  5F91 A;  2J91 A;  2AQL A;  4NSL A;  1XL7 A;  5M0J A;  2LYI A;  1YNN D;  2EZB A;  1DCN A;  2A69 D;  2A6H D;  2NVY A;  2NVX A;  2BE5 D;  2MX8 A;  3LRD A;  2O5J D;  1TJU A;  2X75 A;  3R6V A;  2FEL A;  1TWH A;  2LTH A;  4ADL A;  1Y1W A;  2R93 A;  3GTG A;  3GTK A;  2RJS A;  2LPJ A;  4CEH A;  3KDZ A;  2EZA A;  4C2M A;  3GTQ A;  2VUM A;  1YIS A;  2QGA B;  4EEI A;  3LR2 A;  4C5U A;  3FKI A;  1C3U A;  4MX2 A;  2VSF A;  3UNV A;  1XMD A;  2MQA A;  3GTP A;  1HQM D;  2LPI A;  2HVG A;  1K7W A;  3R6Q A;  1J3U A;  3LR6 A;  1XWO A;  1Y2M A;  3EZA A;  4C6G A;  2A6E D;  1VDK A;  2O6Y A;  1ZYM A;  2X0Q A;  4CEJ A;  2VD6 A;  5D6B A;  5H8W A;  1SMY D;  5EYV A;  4QIW A;  1W27 A;  1TWC A;  2FEN A;  2NYN A;  2JA5 A;  1TJV A;  1YNJ D;  2R7Z A;  4WNL A;  4FBS A;  3GTM A;  2JA6 A;  1GKJ A;  2NYF A;  1FUP A;  3LR8 A;  2FUS A;  3GZH A;  1T6P A;  2HRO A;  3GTO A;  1JSW A;  2O7B A;  1FUO A;  3QBP A;  4NLE A;  1I50 A;  2Y0N A;  1DOF A;  4CEI A;  1I6V D;  1YFE A;  4BAA A;  1TWA A;  2E2H A;  5IZ2 A;  1Y1V A;  2B63 A;  1GKM A;  3GTD A;  3U44 A;  3NO9 A;  3H0G A;  2EZC A;  2VK9 A;  3GTL A;  4ADM A;  2MX9 A;  3U4Q A;  2R92 A;  1Q5N A;  5HW2 A;  3EZE A;  1U15 A;  3CRW 1;  1HY1 A;  3TV2 A;  3BHG A;  2O7D A;  1T6J A;  2PFM A;  1FUR A;  3RRP A;  1TJ7 A;  1EZA A;  4V2R A;  2JA7 A;  5M0I A;  3E04 A;  1SFO A;  4APB A;  1RE5 A;  4HGV A;  1XMC A;  1XL8 A;  1K83 A;  2FIO A;  4A15 A;  1HY0 A;  3CRV A;  2OHY A;  3KDY A;  2K3O A;  4FFX A;  1XLY A;  4APA A;  1FUQ A;  2E2I A;  2YU9 A;  4CQ5 A;  2YII A;  1AUW A;  1ZYR D;  3GTJ A;  2RJR A;  1IW7 D;  3C8T A;  2E9F A;  2HWG A;  2X0P A;  5EYT A;  2MP0 A; 
#chains in the Genus database with same CATH homology
 2QVE A;  1C3C A;  4C5S A;  1GK3 A;  1TJW A;  1B8F A;  2O7E A;  4EFC A;  1GK2 A;  1YFM A;  3NZ4 A;  4BAB A;  1EB4 A;  3OCF A;  1I0A A;  3OCE A;  4C5R A;  1U16 A;  2O78 A;  3RD8 A;  4V2Q A;  2PTS A;  2PTQ A;  3R6Y A;  1K62 A;  2O7F A;  2PTR A;  3CZO A;  5F92 A;  1KQ7 A;  4FLC A;  5F91 A;  2J91 A;  4NSL A;  1DCN A;  3R6V A;  2X75 A;  1TJU A;  4ADL A;  2RJS A;  3KDZ A;  1YIS A;  2QGA B;  4EEI A;  4C5U A;  1C3U A;  4MX2 A;  3UNV A;  2HVG A;  1K7W A;  3R6Q A;  1J3U A;  1XWO A;  1Y2M A;  4C6G A;  1VDK A;  2O6Y A;  5D6B A;  2VD6 A;  5EYV A;  1W27 A;  2NYN A;  1TJV A;  1GKJ A;  2NYF A;  1FUP A;  2FUS A;  3GZH A;  1T6P A;  2O7B A;  3QBP A;  1JSW A;  4NLE A;  1FUO A;  1YFE A;  1DOF A;  4BAA A;  1GKM A;  3GTD A;  3NO9 A;  1Q5N A;  5HW2 A;  1U15 A;  1HY1 A;  3TV2 A;  3BHG A;  2O7D A;  1T6J A;  2PFM A;  1FUR A;  3RRP A;  1TJ7 A;  4V2R A;  3E04 A;  4APB A;  1RE5 A;  4HGV A;  1HY0 A;  2OHY A;  3KDY A;  4FFX A;  4APA A;  1FUQ A;  4CQ5 A;  2YII A;  1AUW A;  2RJR A;  3C8T A;  2E9F A;  4ADM A;  5EYT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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