4C5RA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 264
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
264
sequence length
667
structure length
634
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEACRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALTLVDRLAEFEKRLSDRLENEMTAVRVLYEVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE
total genus 264
structure length 634
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c5rA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c5rA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c5rA02
2O6YA 1AUWA 2YIIA 3NZ4A 1EB4A 3RRPA 3TV2A 1U16A 1K62A 3GZHA 4NSLA 3R6VA 3NO9A 1FUQA 2FUSA 4BABA 4APBA 1TJVA 4BAAA 1DOFA 2O7EA 3CZOA 2X75A 1HY0A 2QVEA 5EYVA 1K7WA 4V2RA 3OCFA 2RJRA 4ADLA 4FFXA 1FURA 1GKMA 5HW2A 1YFEA 3QBPA 2PTQA 2PTSA 3BHGA 1FUOA 1RE5A 5F91A 1YFMA 1YISA 4C6GA 2O78A 1KQ7A 4HGVA 1B8FA 4MX2A 1I0AA 4CQ5A 1W27A 2O7BA 1TJ7A 4NLEA 2J91A 2HVGA 5D6BA 1HY1A 3KDZA 1T6PA 3R6QA 1DCNA 3GTDA 1JSWA 2VD6A 1TJUA 3KDYA 1XWOA 3E04A 1TJWA 1FUPA 1T6JA 3OCEA 4EEIA 4ADMA 2NYFA 4EFCA 4V2QA 4FLCA 1VDKA 3C8TA 2PTRA 3R6YA 2RJSA 5F92A 2O7DA 3RD8A 1Y2MA 1C3UA 2QGAB 4APAA 2E9FA 1Q5NA 1GK2A 3UNVA 1GKJA 2O7FA 1GK3A 1C3CA 2PFMA 4C5RA 4C5UA 1J3UA 1U15A 5EYTA 4C5SA 2NYNA 2OHYA
chains in the Genus database with same CATH superfamily
2O6YA 2VL7A 1AUWA 2X0OA 2YIIA 3EZAA 3NZ4A 1EB4A 2R93A 3RRPA 3TV2A 1U16A 1R9TA 1K62A 3GZHA 4NSLA 3R6VA 2LTHA 3NO9A 1FUQA 2FUSA 4BABA 4APBA 2JA6A 4QIWA 1TJVA 1I50A 4BAAA 1DOFA 2O7EA 3CZOA 2X75A 5M0JA 2OHYA 1HY0A 4FBSA 2E2IA 2NVXA 3GTMA 2R92A 1IW7D 2B63A 2R7ZA 2QVEA 3EZEA 2A6ED 3CQZA 3LR2A 3LRDA 2CW0D 2VK9A 5EYVA 1K7WA 1TWCA 4V2RA 3CRW1 3OCFA 2RJRA 4ADLA 2F5JA 4FFXA 1FURA 1GKMA 5HW2A 5IZ2A 2LPIA 1YFEA 3QBPA 2PTQA 2PTSA 2X0PA 1Y1WA 1TWGA 3BHGA 1FUOA 1RE5A 2MP0A 5F91A 1YFMA 2JA7A 1YISA 4C6GA 2O78A 2MQAA 1KQ7A 1TWFA 1B8FA 4HGVA 3LR8A 4MX2A 1I0AA 2N3EA 2LKMB 4CQ5A 2A68D 3FKIA 1W27A 1SMYD 2O7BA 1XLYA 4WNLA 1TJ7A 4CEHA 4NLEA 2J91A 3GTKA 2HVGA 5D6BA 2K3QA 1SFOA 1WCMA 1HY1A 3KDZA 4A15A 1T6PA 2NVYA 1K83A 4C2MA 3R6QA 2FELA 1Y1VA 1DCNA 3GTJA 2EZBA 3GTDA 2HWGA 1JSWA 2JA5A 2VD6A 1TWAA 3LR6A 5H8WA 1TJUA 2EZAA 1HQMD 1I3QA 3EZBA 3KDYA 1TWHA 1XWOA 3E04A 2MX8A 1TJWA 3CRVA 1FUPA 1ZYRD 1T6JA 2K3OA 1XMDA 3OCEA 3GTQA 1XL8A 4ADMA 2NYFA 2VUMA 4EEIA 4EFCA 3U4QA 4V2QA 2YU9A 4FLCA 1VDKA 2FIPA 1ZYMA 2K3NA 3C8TA 1XMCA 1I6VD 2PTRA 2Y0NA 3R6YA 2RJSA 5F92A 2O7DA 2EZCA 3RD8A 5M0IA 2AQLA 1Y2MA 1C3UA 4CEIA 3U44A 3GTOA 1EZBA 4CEJA 2A6HD 2QGAB 2E9FA 4APAA 1Q5NA 3GTLA 2O5JD 1GK2A 3UNVA 1YNJD 3GTPA 1GKJA 2HROA 2VSFA 2O7FA 2LPJA 3H0GA 2MX9A 2FIOA 1C3CA 1GK3A 1XL7A 2PFMA 2A69D 4C5RA 1YNND 2LYIA 4C5UA 2FENA 1J3UA 2BE5D 1EZAA 3GTGA 4C5SA 1U15A 2N1DB 2X0QA 2NYNA 5EYTA 2E2HA
chains in the Genus database with same CATH topology
2O6YA 1AUWA 2YIIA 3NZ4A 1EB4A 3RRPA 3TV2A 1U16A 1K62A 3GZHA 4NSLA 3R6VA 3NO9A 1FUQA 2FUSA 4BABA 4APBA 1TJVA 4BAAA 1DOFA 2O7EA 3CZOA 2X75A 1HY0A 2QVEA 5EYVA 1K7WA 4V2RA 3OCFA 2RJRA 4ADLA 4FFXA 1FURA 1GKMA 5HW2A 1YFEA 3QBPA 2PTQA 2PTSA 3BHGA 1FUOA 1RE5A 5F91A 1YFMA 1YISA 4C6GA 2O78A 1KQ7A 4HGVA 1B8FA 4MX2A 1I0AA 4CQ5A 1W27A 2O7BA 1TJ7A 4NLEA 2J91A 2HVGA 5D6BA 1HY1A 3KDZA 1T6PA 3R6QA 1DCNA 3GTDA 1JSWA 2VD6A 1TJUA 3KDYA 1XWOA 3E04A 1TJWA 1FUPA 1T6JA 3OCEA 4EEIA 4ADMA 2NYFA 4EFCA 4V2QA 4FLCA 1VDKA 3C8TA 2PTRA 3R6YA 2RJSA 5F92A 2O7DA 3RD8A 1Y2MA 1C3UA 2QGAB 4APAA 2E9FA 1Q5NA 1GK2A 3UNVA 1GKJA 2O7FA 1GK3A 1C3CA 2PFMA 4C5RA 4C5UA 1J3UA 1U15A 5EYTA 4C5SA 2NYNA 2OHYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2O6Y A;  1AUW A;  2YII A;  3NZ4 A;  1EB4 A;  3RRP A;  3TV2 A;  1U16 A;  1K62 A;  3GZH A;  4NSL A;  3R6V A;  3NO9 A;  1FUQ A;  2FUS A;  4BAB A;  4APB A;  1TJV A;  4BAA A;  1DOF A;  2O7E A;  3CZO A;  2X75 A;  1HY0 A;  2QVE A;  5EYV A;  1K7W A;  4V2R A;  3OCF A;  2RJR A;  4ADL A;  4FFX A;  1FUR A;  1GKM A;  5HW2 A;  1YFE A;  3QBP A;  2PTQ A;  2PTS A;  3BHG A;  1FUO A;  1RE5 A;  5F91 A;  1YFM A;  1YIS A;  4C6G A;  2O78 A;  1KQ7 A;  4HGV A;  1B8F A;  4MX2 A;  1I0A A;  4CQ5 A;  1W27 A;  2O7B A;  1TJ7 A;  4NLE A;  2J91 A;  2HVG A;  5D6B A;  1HY1 A;  3KDZ A;  1T6P A;  3R6Q A;  1DCN A;  3GTD A;  1JSW A;  2VD6 A;  1TJU A;  3KDY A;  1XWO A;  3E04 A;  1TJW A;  1FUP A;  1T6J A;  3OCE A;  4EEI A;  4ADM A;  2NYF A;  4EFC A;  4V2Q A;  4FLC A;  1VDK A;  3C8T A;  2PTR A;  3R6Y A;  2RJS A;  5F92 A;  2O7D A;  3RD8 A;  1Y2M A;  1C3U A;  2QGA B;  4APA A;  2E9F A;  1Q5N A;  1GK2 A;  3UNV A;  1GKJ A;  2O7F A;  1GK3 A;  1C3C A;  2PFM A;  4C5R A;  4C5U A;  1J3U A;  1U15 A;  5EYT A;  4C5S A;  2NYN A;  2OHY A; 
#chains in the Genus database with same CATH topology
 2O6Y A;  2VL7 A;  1AUW A;  2X0O A;  2YII A;  3EZA A;  3NZ4 A;  1EB4 A;  2R93 A;  3RRP A;  3TV2 A;  1U16 A;  1R9T A;  1K62 A;  3GZH A;  4NSL A;  3R6V A;  2LTH A;  3NO9 A;  1FUQ A;  2FUS A;  4BAB A;  4APB A;  2JA6 A;  4QIW A;  1TJV A;  1I50 A;  4BAA A;  1DOF A;  2O7E A;  3CZO A;  2X75 A;  5M0J A;  2OHY A;  1HY0 A;  4FBS A;  2E2I A;  2NVX A;  3GTM A;  2R92 A;  1IW7 D;  2B63 A;  2R7Z A;  2QVE A;  3EZE A;  2A6E D;  3CQZ A;  3LR2 A;  3LRD A;  2CW0 D;  2VK9 A;  5EYV A;  1K7W A;  1TWC A;  4V2R A;  3CRW 1;  3OCF A;  2RJR A;  4ADL A;  2F5J A;  4FFX A;  1FUR A;  1GKM A;  5HW2 A;  5IZ2 A;  2LPI A;  1YFE A;  3QBP A;  2PTQ A;  2PTS A;  2X0P A;  1Y1W A;  1TWG A;  3BHG A;  1FUO A;  1RE5 A;  2MP0 A;  5F91 A;  1YFM A;  2JA7 A;  1YIS A;  4C6G A;  2O78 A;  2MQA A;  1KQ7 A;  1TWF A;  1B8F A;  4HGV A;  3LR8 A;  4MX2 A;  1I0A A;  2N3E A;  2LKM B;  4CQ5 A;  2A68 D;  3FKI A;  1W27 A;  1SMY D;  2O7B A;  1XLY A;  4WNL A;  1TJ7 A;  4CEH A;  4NLE A;  2J91 A;  3GTK A;  2HVG A;  5D6B A;  2K3Q A;  1SFO A;  1WCM A;  1HY1 A;  3KDZ A;  4A15 A;  1T6P A;  2NVY A;  1K83 A;  4C2M A;  3R6Q A;  2FEL A;  1Y1V A;  1DCN A;  3GTJ A;  2EZB A;  3GTD A;  2HWG A;  1JSW A;  2JA5 A;  2VD6 A;  1TWA A;  3LR6 A;  5H8W A;  1TJU A;  2EZA A;  1HQM D;  1I3Q A;  3EZB A;  3KDY A;  1TWH A;  1XWO A;  3E04 A;  2MX8 A;  1TJW A;  3CRV A;  1FUP A;  1ZYR D;  1T6J A;  2K3O A;  1XMD A;  3OCE A;  3GTQ A;  1XL8 A;  4ADM A;  2NYF A;  2VUM A;  4EEI A;  4EFC A;  3U4Q A;  4V2Q A;  2YU9 A;  4FLC A;  1VDK A;  2FIP A;  1ZYM A;  2K3N A;  3C8T A;  1XMC A;  1I6V D;  2PTR A;  2Y0N A;  3R6Y A;  2RJS A;  5F92 A;  2O7D A;  2EZC A;  3RD8 A;  5M0I A;  2AQL A;  1Y2M A;  1C3U A;  4CEI A;  3U44 A;  3GTO A;  1EZB A;  4CEJ A;  2A6H D;  2QGA B;  2E9F A;  4APA A;  1Q5N A;  3GTL A;  2O5J D;  1GK2 A;  3UNV A;  1YNJ D;  3GTP A;  1GKJ A;  2HRO A;  2VSF A;  2O7F A;  2LPJ A;  3H0G A;  2MX9 A;  2FIO A;  1C3C A;  1GK3 A;  1XL7 A;  2PFM A;  2A69 D;  4C5R A;  1YNN D;  2LYI A;  4C5U A;  2FEN A;  1J3U A;  2BE5 D;  1EZA A;  3GTG A;  4C5S A;  1U15 A;  2N1D B;  2X0Q A;  2NYN A;  5EYT A;  2E2H A; 
#chains in the Genus database with same CATH homology
 2O6Y A;  1AUW A;  2YII A;  3NZ4 A;  1EB4 A;  3RRP A;  3TV2 A;  1U16 A;  1K62 A;  3GZH A;  4NSL A;  3R6V A;  3NO9 A;  1FUQ A;  2FUS A;  4BAB A;  4APB A;  1TJV A;  4BAA A;  1DOF A;  2O7E A;  3CZO A;  2X75 A;  1HY0 A;  2QVE A;  5EYV A;  1K7W A;  4V2R A;  3OCF A;  2RJR A;  4ADL A;  4FFX A;  1FUR A;  1GKM A;  5HW2 A;  1YFE A;  3QBP A;  2PTQ A;  2PTS A;  3BHG A;  1FUO A;  1RE5 A;  5F91 A;  1YFM A;  1YIS A;  4C6G A;  2O78 A;  1KQ7 A;  4HGV A;  1B8F A;  4MX2 A;  1I0A A;  4CQ5 A;  1W27 A;  2O7B A;  1TJ7 A;  4NLE A;  2J91 A;  2HVG A;  5D6B A;  1HY1 A;  3KDZ A;  1T6P A;  3R6Q A;  1DCN A;  3GTD A;  1JSW A;  2VD6 A;  1TJU A;  3KDY A;  1XWO A;  3E04 A;  1TJW A;  1FUP A;  1T6J A;  3OCE A;  4EEI A;  4ADM A;  2NYF A;  4EFC A;  4V2Q A;  4FLC A;  1VDK A;  3C8T A;  2PTR A;  3R6Y A;  2RJS A;  5F92 A;  2O7D A;  3RD8 A;  1Y2M A;  1C3U A;  2QGA B;  4APA A;  2E9F A;  1Q5N A;  1GK2 A;  3UNV A;  1GKJ A;  2O7F A;  1GK3 A;  1C3C A;  2PFM A;  4C5R A;  4C5U A;  1J3U A;  1U15 A;  5EYT A;  4C5S A;  2NYN A;  2OHY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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