4C5RA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 264
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
264
sequence length
667
structure length
634
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEACRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALTLVDRLAEFEKRLSDRLENEMTAVRVLYEVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE
publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
total genus 264
structure length 634
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c5rA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c5rA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c5rA02
4V2QA 1YFEA 5EYVA 1YISA 4MX2A 1GK3A 4EFCA 1C3CA 2O7BA 1Q5NA 4BAAA 2O78A 3KDZA 3TV2A 4BABA 1K7WA 1U16A 4HGVA 3UNVA 1T6PA 1TJWA 2QVEA 1TJ7A 3NO9A 2RJSA 1GKJA 1JSWA 2PTQA 5EYTA 1C3UA 5HW2A 2PFMA 1J3UA 1HY1A 1HY0A 1U15A 1XWOA 3R6YA 3GTDA 2O7EA 1KQ7A 2O6YA 1FUPA 2HVGA 4ADMA 4APBA 4NLEA 3R6QA 2NYNA 3OCEA 1FURA 1DOFA 1Y2MA 1RE5A 4C5UA 2QGAB 4C5RA 4FFXA 5D6BA 1B8FA 4APAA 1EB4A 2O7DA 1DCNA 1FUOA 3C8TA 4ADLA 3OCFA 1I0AA 4CQ5A 5F92A 4C6GA 1TJUA 4NSLA 4EEIA 3R6VA 1FUQA 2X75A 4FLCA 1AUWA 3QBPA 3KDYA 2PTSA 3CZOA 1W27A 1TJVA 2O7FA 2RJRA 3RD8A 1VDKA 2E9FA 3E04A 1K62A 2NYFA 3BHGA 2PTRA 4V2RA 1GKMA 1YFMA 5F91A 3NZ4A 2J91A 2VD6A 2YIIA 4C5SA 2FUSA 3RRPA 1GK2A 1T6JA 3GZHA 2OHYA
chains in the Genus database with same CATH superfamily
1XLYA 4V2QA 3CRW1 2EZCA 2VSFA 2BE5D 1YFEA 3GTJA 5EYVA 1YISA 4MX2A 1GK3A 2O5JD 4EFCA 4FBSA 1TWHA 1C3CA 2O7BA 1Q5NA 1EZAA 3LRDA 2B63A 4BAAA 1R9TA 2MX9A 1XL8A 2O78A 3U44A 1TWCA 3KDZA 3TV2A 2LKMB 2MX8A 3CRVA 4BABA 1K7WA 1U16A 4HGVA 3UNVA 1T6PA 1TJWA 2QVEA 2EZAA 1TJ7A 3NO9A 2RJSA 2LPIA 1GKJA 2E2IA 1JSWA 2PTQA 5EYTA 1C3UA 5HW2A 4CEIA 2AQLA 1Y1WA 1J3UA 2PFMA 1HY1A 5M0JA 1HY0A 2R92A 1U15A 3U4QA 1XWOA 3R6YA 1SMYD 1WCMA 3GTDA 1TWAA 2O7EA 1KQ7A 2LPJA 2R93A 2O6YA 1EZBA 5M0IA 1FUPA 2JA5A 2HVGA 4ADMA 3GTKA 4NLEA 1K83A 2NYNA 3R6QA 4APBA 2E2HA 4CEHA 3OCEA 3CQZA 1DOFA 1FURA 1Y2MA 2A68D 3H0GA 2LYIA 1RE5A 4C5UA 2QGAB 3LR8A 1XL7A 4C5RA 4FFXA 2EZBA 2Y0NA 5D6BA 1I6VD 1B8FA 4APAA 3GTQA 2K3NA 1EB4A 2O7DA 1DCNA 3EZEA 1SFOA 1FUOA 2X0OA 3C8TA 4CEJA 4ADLA 1XMCA 3OCFA 2CW0D 1I0AA 4CQ5A 5F92A 3LR6A 2X0QA 4C6GA 2HROA 1TJUA 2VUMA 2A69D 4NSLA 4EEIA 2A6ED 3FKIA 3R6VA 1FUQA 5H8WA 2VK9A 3GTLA 2X75A 2FIPA 2FELA 4FLCA 1AUWA 3QBPA 4C2MA 2K3OA 2LTHA 3EZAA 3KDYA 4WNLA 2YU9A 2MP0A 2PTSA 1YNND 2FENA 3GTMA 2JA6A 3CZOA 1W27A 4QIWA 1TJVA 2O7FA 2RJRA 3RD8A 2HWGA 2JA7A 1VDKA 2NVXA 2MQAA 3GTGA 2E9FA 3GTPA 1XMDA 2NVYA 1ZYMA 2R7ZA 2VL7A 3E04A 2N1DB 1I50A 1K62A 2NYFA 2X0PA 5IZ2A 3BHGA 2PTRA 4V2RA 2F5JA 1YNJD 1GKMA 1YFMA 5F91A 3NZ4A 4A15A 2J91A 2VD6A 1TWFA 1ZYRD 2A6HD 2YIIA 1Y1VA 1TWGA 4C5SA 1I3QA 2FUSA 2FIOA 3RRPA 1IW7D 1GK2A 3GTOA 1T6JA 3EZBA 1HQMD 2N3EA 2K3QA 3LR2A 3GZHA 2OHYA
chains in the Genus database with same CATH topology
4V2QA 1YFEA 5EYVA 1YISA 4MX2A 1GK3A 4EFCA 1C3CA 2O7BA 1Q5NA 4BAAA 2O78A 3KDZA 3TV2A 4BABA 1K7WA 1U16A 4HGVA 3UNVA 1T6PA 1TJWA 2QVEA 1TJ7A 3NO9A 2RJSA 1GKJA 1JSWA 2PTQA 5EYTA 1C3UA 5HW2A 2PFMA 1J3UA 1HY1A 1HY0A 1U15A 1XWOA 3R6YA 3GTDA 2O7EA 1KQ7A 2O6YA 1FUPA 2HVGA 4ADMA 4APBA 4NLEA 3R6QA 2NYNA 3OCEA 1FURA 1DOFA 1Y2MA 1RE5A 4C5UA 2QGAB 4C5RA 4FFXA 5D6BA 1B8FA 4APAA 1EB4A 2O7DA 1DCNA 1FUOA 3C8TA 4ADLA 3OCFA 1I0AA 4CQ5A 5F92A 4C6GA 1TJUA 4NSLA 4EEIA 3R6VA 1FUQA 2X75A 4FLCA 1AUWA 3QBPA 3KDYA 2PTSA 3CZOA 1W27A 1TJVA 2O7FA 2RJRA 3RD8A 1VDKA 2E9FA 3E04A 1K62A 2NYFA 3BHGA 2PTRA 4V2RA 1GKMA 1YFMA 5F91A 3NZ4A 2J91A 2VD6A 2YIIA 4C5SA 2FUSA 3RRPA 1GK2A 1T6JA 3GZHA 2OHYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4V2Q A;  1YFE A;  5EYV A;  1YIS A;  4MX2 A;  1GK3 A;  4EFC A;  1C3C A;  2O7B A;  1Q5N A;  4BAA A;  2O78 A;  3KDZ A;  3TV2 A;  4BAB A;  1K7W A;  1U16 A;  4HGV A;  3UNV A;  1T6P A;  1TJW A;  2QVE A;  1TJ7 A;  3NO9 A;  2RJS A;  1GKJ A;  1JSW A;  2PTQ A;  5EYT A;  1C3U A;  5HW2 A;  2PFM A;  1J3U A;  1HY1 A;  1HY0 A;  1U15 A;  1XWO A;  3R6Y A;  3GTD A;  2O7E A;  1KQ7 A;  2O6Y A;  1FUP A;  2HVG A;  4ADM A;  4APB A;  4NLE A;  3R6Q A;  2NYN A;  3OCE A;  1FUR A;  1DOF A;  1Y2M A;  1RE5 A;  4C5U A;  2QGA B;  4C5R A;  4FFX A;  5D6B A;  1B8F A;  4APA A;  1EB4 A;  2O7D A;  1DCN A;  1FUO A;  3C8T A;  4ADL A;  3OCF A;  1I0A A;  4CQ5 A;  5F92 A;  4C6G A;  1TJU A;  4NSL A;  4EEI A;  3R6V A;  1FUQ A;  2X75 A;  4FLC A;  1AUW A;  3QBP A;  3KDY A;  2PTS A;  3CZO A;  1W27 A;  1TJV A;  2O7F A;  2RJR A;  3RD8 A;  1VDK A;  2E9F A;  3E04 A;  1K62 A;  2NYF A;  3BHG A;  2PTR A;  4V2R A;  1GKM A;  1YFM A;  5F91 A;  3NZ4 A;  2J91 A;  2VD6 A;  2YII A;  4C5S A;  2FUS A;  3RRP A;  1GK2 A;  1T6J A;  3GZH A;  2OHY A; 
#chains in the Genus database with same CATH topology
 1XLY A;  4V2Q A;  3CRW 1;  2EZC A;  2VSF A;  2BE5 D;  1YFE A;  3GTJ A;  5EYV A;  1YIS A;  4MX2 A;  1GK3 A;  2O5J D;  4EFC A;  4FBS A;  1TWH A;  1C3C A;  2O7B A;  1Q5N A;  1EZA A;  3LRD A;  2B63 A;  4BAA A;  1R9T A;  2MX9 A;  1XL8 A;  2O78 A;  3U44 A;  1TWC A;  3KDZ A;  3TV2 A;  2LKM B;  2MX8 A;  3CRV A;  4BAB A;  1K7W A;  1U16 A;  4HGV A;  3UNV A;  1T6P A;  1TJW A;  2QVE A;  2EZA A;  1TJ7 A;  3NO9 A;  2RJS A;  2LPI A;  1GKJ A;  2E2I A;  1JSW A;  2PTQ A;  5EYT A;  1C3U A;  5HW2 A;  4CEI A;  2AQL A;  1Y1W A;  1J3U A;  2PFM A;  1HY1 A;  5M0J A;  1HY0 A;  2R92 A;  1U15 A;  3U4Q A;  1XWO A;  3R6Y A;  1SMY D;  1WCM A;  3GTD A;  1TWA A;  2O7E A;  1KQ7 A;  2LPJ A;  2R93 A;  2O6Y A;  1EZB A;  5M0I A;  1FUP A;  2JA5 A;  2HVG A;  4ADM A;  3GTK A;  4NLE A;  1K83 A;  2NYN A;  3R6Q A;  4APB A;  2E2H A;  4CEH A;  3OCE A;  3CQZ A;  1DOF A;  1FUR A;  1Y2M A;  2A68 D;  3H0G A;  2LYI A;  1RE5 A;  4C5U A;  2QGA B;  3LR8 A;  1XL7 A;  4C5R A;  4FFX A;  2EZB A;  2Y0N A;  5D6B A;  1I6V D;  1B8F A;  4APA A;  3GTQ A;  2K3N A;  1EB4 A;  2O7D A;  1DCN A;  3EZE A;  1SFO A;  1FUO A;  2X0O A;  3C8T A;  4CEJ A;  4ADL A;  1XMC A;  3OCF A;  2CW0 D;  1I0A A;  4CQ5 A;  5F92 A;  3LR6 A;  2X0Q A;  4C6G A;  2HRO A;  1TJU A;  2VUM A;  2A69 D;  4NSL A;  4EEI A;  2A6E D;  3FKI A;  3R6V A;  1FUQ A;  5H8W A;  2VK9 A;  3GTL A;  2X75 A;  2FIP A;  2FEL A;  4FLC A;  1AUW A;  3QBP A;  4C2M A;  2K3O A;  2LTH A;  3EZA A;  3KDY A;  4WNL A;  2YU9 A;  2MP0 A;  2PTS A;  1YNN D;  2FEN A;  3GTM A;  2JA6 A;  3CZO A;  1W27 A;  4QIW A;  1TJV A;  2O7F A;  2RJR A;  3RD8 A;  2HWG A;  2JA7 A;  1VDK A;  2NVX A;  2MQA A;  3GTG A;  2E9F A;  3GTP A;  1XMD A;  2NVY A;  1ZYM A;  2R7Z A;  2VL7 A;  3E04 A;  2N1D B;  1I50 A;  1K62 A;  2NYF A;  2X0P A;  5IZ2 A;  3BHG A;  2PTR A;  4V2R A;  2F5J A;  1YNJ D;  1GKM A;  1YFM A;  5F91 A;  3NZ4 A;  4A15 A;  2J91 A;  2VD6 A;  1TWF A;  1ZYR D;  2A6H D;  2YII A;  1Y1V A;  1TWG A;  4C5S A;  1I3Q A;  2FUS A;  2FIO A;  3RRP A;  1IW7 D;  1GK2 A;  3GTO A;  1T6J A;  3EZB A;  1HQM D;  2N3E A;  2K3Q A;  3LR2 A;  3GZH A;  2OHY A; 
#chains in the Genus database with same CATH homology
 4V2Q A;  1YFE A;  5EYV A;  1YIS A;  4MX2 A;  1GK3 A;  4EFC A;  1C3C A;  2O7B A;  1Q5N A;  4BAA A;  2O78 A;  3KDZ A;  3TV2 A;  4BAB A;  1K7W A;  1U16 A;  4HGV A;  3UNV A;  1T6P A;  1TJW A;  2QVE A;  1TJ7 A;  3NO9 A;  2RJS A;  1GKJ A;  1JSW A;  2PTQ A;  5EYT A;  1C3U A;  5HW2 A;  2PFM A;  1J3U A;  1HY1 A;  1HY0 A;  1U15 A;  1XWO A;  3R6Y A;  3GTD A;  2O7E A;  1KQ7 A;  2O6Y A;  1FUP A;  2HVG A;  4ADM A;  4APB A;  4NLE A;  3R6Q A;  2NYN A;  3OCE A;  1FUR A;  1DOF A;  1Y2M A;  1RE5 A;  4C5U A;  2QGA B;  4C5R A;  4FFX A;  5D6B A;  1B8F A;  4APA A;  1EB4 A;  2O7D A;  1DCN A;  1FUO A;  3C8T A;  4ADL A;  3OCF A;  1I0A A;  4CQ5 A;  5F92 A;  4C6G A;  1TJU A;  4NSL A;  4EEI A;  3R6V A;  1FUQ A;  2X75 A;  4FLC A;  1AUW A;  3QBP A;  3KDY A;  2PTS A;  3CZO A;  1W27 A;  1TJV A;  2O7F A;  2RJR A;  3RD8 A;  1VDK A;  2E9F A;  3E04 A;  1K62 A;  2NYF A;  3BHG A;  2PTR A;  4V2R A;  1GKM A;  1YFM A;  5F91 A;  3NZ4 A;  2J91 A;  2VD6 A;  2YII A;  4C5S A;  2FUS A;  3RRP A;  1GK2 A;  1T6J A;  3GZH A;  2OHY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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