4C5RA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 264
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
264
sequence length
667
structure length
634
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEACRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALTLVDRLAEFEKRLSDRLENEMTAVRVLYEVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMMONIA-LYASE
publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 264
structure length 634
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c5rA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c5rA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c5rA02
4V2RA 1FUOA 2NYNA 3GZHA 2PTSA 3GTDA 3CZOA 4C5SA 3RD8A 3UNVA 4C6GA 1Q5NA 3NZ4A 1U15A 2O7EA 1JSWA 1U16A 2RJSA 2VD6A 5F92A 3OCEA 2NYFA 1W27A 4V2QA 3NO9A 1GK3A 2E9FA 2X75A 5EYTA 1K62A 1FUPA 1C3CA 4FLCA 1TJ7A 1DCNA 1TJUA 1YFMA 2O7FA 2PTRA 1C3UA 2O7DA 1YISA 2QGAB 1GKMA 4BABA 1AUWA 4CQ5A 4APBA 2O6YA 1T6PA 2PTQA 4HGVA 4APAA 1EB4A 4EFCA 1J3UA 4ADLA 1Y2MA 1GK2A 4MX2A 4NLEA 4ADMA 3KDYA 1VDKA 3C8TA 3QBPA 2RJRA 1XWOA 2OHYA 2HVGA 1DOFA 3TV2A 3BHGA 1KQ7A 2PFMA 1YFEA 5F91A 5D6BA 3R6YA 2FUSA 1TJVA 1RE5A 1GKJA 2J91A 3OCFA 4BAAA 1B8FA 2QVEA 3RRPA 1FURA 3R6QA 4EEIA 5HW2A 1FUQA 1HY0A 4C5UA 1K7WA 1I0AA 3R6VA 2O7BA 1T6JA 1TJWA 5EYVA 2YIIA 3KDZA 4NSLA 3E04A 4FFXA 2O78A 4C5RA 1HY1A
chains in the Genus database with same CATH superfamily
4QIWA 3CQZA 4A15A 4V2RA 3GTGA 1XMDA 2FENA 1I50A 1FUOA 2NYNA 2LYIA 1SFOA 3CRVA 2HWGA 5H8WA 3GZHA 2PTSA 2F5JA 3GTDA 4C2MA 3CZOA 4C5SA 3RD8A 3UNVA 4C6GA 2E2IA 1Q5NA 3GTOA 3NZ4A 1U15A 1XL8A 2MQAA 3CRW1 2O7EA 3GTMA 3GTLA 2K3NA 1XL7A 2FELA 2VK9A 1JSWA 1U16A 2RJSA 2VD6A 5F92A 2X0OA 3U4QA 2O5JD 2NYFA 3OCEA 4WNLA 4V2QA 1W27A 3NO9A 4CEIA 1ZYRD 3GTJA 2E9FA 2X75A 2N1DB 5EYTA 1XLYA 2EZAA 1K62A 1FUPA 2E2HA 1TWHA 1HQMD 1C3CA 2LPJA 4FLCA 2X0QA 1K83A 1TWAA 1TJ7A 1DCNA 1Y1VA 1TJUA 2K3QA 1YFMA 2O7FA 2PTRA 2R93A 3U44A 1C3UA 2O7DA 2MX8A 1YNND 2JA7A 3LR6A 1YISA 1XMCA 2QGAB 1GKMA 1TWCA 4BABA 2VUMA 3FKIA 2A6ED 1AUWA 2A68D 4CQ5A 5IZ2A 4APBA 2O6YA 1T6PA 1WCMA 2LPIA 2FIOA 2A69D 2PTQA 3EZEA 2BE5D 4HGVA 4APAA 3GTPA 1EB4A 1IW7D 4EFCA 1TWGA 1J3UA 2AQLA 4ADLA 1Y2MA 3EZAA 4CEHA 1GK2A 2HROA 4MX2A 4NLEA 1SMYD 1EZBA 4ADMA 3KDYA 1VDKA 3C8TA 3QBPA 2JA6A 5M0JA 4FBSA 2RJRA 2R92A 1XWOA 2VSFA 2OHYA 2HVGA 2MX9A 1DOFA 3TV2A 3BHGA 3LRDA 5M0IA 2NVYA 1KQ7A 2PFMA 1YFEA 5F91A 1EZAA 5D6BA 1ZYMA 2FUSA 2NVXA 2A6HD 1TJVA 3R6YA 1RE5A 3GTQA 1GKJA 3EZBA 2J91A 3GTKA 3OCFA 4BAAA 2EZBA 2VL7A 2MP0A 1B8FA 2QVEA 3RRPA 3H0GA 1FURA 2X0PA 2N3EA 1TWFA 3R6QA 4EEIA 1HY1A 2YU9A 2LKMB 4CEJA 2JA5A 5HW2A 1Y1WA 1FUQA 1YNJD 1HY0A 4C5UA 2EZCA 2FIPA 3LR2A 1K7WA 1I3QA 1I0AA 2B63A 2Y0NA 3R6VA 3LR8A 2O7BA 1T6JA 1TJWA 2R7ZA 5EYVA 2YIIA 3KDZA 1R9TA 4NSLA 2K3OA 3E04A 4FFXA 2LTHA 2O78A 2CW0D 4C5RA 1I6VD 1GK3A
chains in the Genus database with same CATH topology
4V2RA 1FUOA 2NYNA 3GZHA 2PTSA 3GTDA 3CZOA 4C5SA 3RD8A 3UNVA 4C6GA 1Q5NA 3NZ4A 1U15A 2O7EA 1JSWA 1U16A 2RJSA 2VD6A 5F92A 3OCEA 2NYFA 1W27A 4V2QA 3NO9A 1GK3A 2E9FA 2X75A 5EYTA 1K62A 1FUPA 1C3CA 4FLCA 1TJ7A 1DCNA 1TJUA 1YFMA 2O7FA 2PTRA 1C3UA 2O7DA 1YISA 2QGAB 1GKMA 4BABA 1AUWA 4CQ5A 4APBA 2O6YA 1T6PA 2PTQA 4HGVA 4APAA 1EB4A 4EFCA 1J3UA 4ADLA 1Y2MA 1GK2A 4MX2A 4NLEA 4ADMA 3KDYA 1VDKA 3C8TA 3QBPA 2RJRA 1XWOA 2OHYA 2HVGA 1DOFA 3TV2A 3BHGA 1KQ7A 2PFMA 1YFEA 5F91A 5D6BA 3R6YA 2FUSA 1TJVA 1RE5A 1GKJA 2J91A 3OCFA 4BAAA 1B8FA 2QVEA 3RRPA 1FURA 3R6QA 4EEIA 5HW2A 1FUQA 1HY0A 4C5UA 1K7WA 1I0AA 3R6VA 2O7BA 1T6JA 1TJWA 5EYVA 2YIIA 3KDZA 4NSLA 3E04A 4FFXA 2O78A 4C5RA 1HY1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4V2R A;  1FUO A;  2NYN A;  3GZH A;  2PTS A;  3GTD A;  3CZO A;  4C5S A;  3RD8 A;  3UNV A;  4C6G A;  1Q5N A;  3NZ4 A;  1U15 A;  2O7E A;  1JSW A;  1U16 A;  2RJS A;  2VD6 A;  5F92 A;  3OCE A;  2NYF A;  1W27 A;  4V2Q A;  3NO9 A;  1GK3 A;  2E9F A;  2X75 A;  5EYT A;  1K62 A;  1FUP A;  1C3C A;  4FLC A;  1TJ7 A;  1DCN A;  1TJU A;  1YFM A;  2O7F A;  2PTR A;  1C3U A;  2O7D A;  1YIS A;  2QGA B;  1GKM A;  4BAB A;  1AUW A;  4CQ5 A;  4APB A;  2O6Y A;  1T6P A;  2PTQ A;  4HGV A;  4APA A;  1EB4 A;  4EFC A;  1J3U A;  4ADL A;  1Y2M A;  1GK2 A;  4MX2 A;  4NLE A;  4ADM A;  3KDY A;  1VDK A;  3C8T A;  3QBP A;  2RJR A;  1XWO A;  2OHY A;  2HVG A;  1DOF A;  3TV2 A;  3BHG A;  1KQ7 A;  2PFM A;  1YFE A;  5F91 A;  5D6B A;  3R6Y A;  2FUS A;  1TJV A;  1RE5 A;  1GKJ A;  2J91 A;  3OCF A;  4BAA A;  1B8F A;  2QVE A;  3RRP A;  1FUR A;  3R6Q A;  4EEI A;  5HW2 A;  1FUQ A;  1HY0 A;  4C5U A;  1K7W A;  1I0A A;  3R6V A;  2O7B A;  1T6J A;  1TJW A;  5EYV A;  2YII A;  3KDZ A;  4NSL A;  3E04 A;  4FFX A;  2O78 A;  4C5R A;  1HY1 A; 
#chains in the Genus database with same CATH topology
 4QIW A;  3CQZ A;  4A15 A;  4V2R A;  3GTG A;  1XMD A;  2FEN A;  1I50 A;  1FUO A;  2NYN A;  2LYI A;  1SFO A;  3CRV A;  2HWG A;  5H8W A;  3GZH A;  2PTS A;  2F5J A;  3GTD A;  4C2M A;  3CZO A;  4C5S A;  3RD8 A;  3UNV A;  4C6G A;  2E2I A;  1Q5N A;  3GTO A;  3NZ4 A;  1U15 A;  1XL8 A;  2MQA A;  3CRW 1;  2O7E A;  3GTM A;  3GTL A;  2K3N A;  1XL7 A;  2FEL A;  2VK9 A;  1JSW A;  1U16 A;  2RJS A;  2VD6 A;  5F92 A;  2X0O A;  3U4Q A;  2O5J D;  2NYF A;  3OCE A;  4WNL A;  4V2Q A;  1W27 A;  3NO9 A;  4CEI A;  1ZYR D;  3GTJ A;  2E9F A;  2X75 A;  2N1D B;  5EYT A;  1XLY A;  2EZA A;  1K62 A;  1FUP A;  2E2H A;  1TWH A;  1HQM D;  1C3C A;  2LPJ A;  4FLC A;  2X0Q A;  1K83 A;  1TWA A;  1TJ7 A;  1DCN A;  1Y1V A;  1TJU A;  2K3Q A;  1YFM A;  2O7F A;  2PTR A;  2R93 A;  3U44 A;  1C3U A;  2O7D A;  2MX8 A;  1YNN D;  2JA7 A;  3LR6 A;  1YIS A;  1XMC A;  2QGA B;  1GKM A;  1TWC A;  4BAB A;  2VUM A;  3FKI A;  2A6E D;  1AUW A;  2A68 D;  4CQ5 A;  5IZ2 A;  4APB A;  2O6Y A;  1T6P A;  1WCM A;  2LPI A;  2FIO A;  2A69 D;  2PTQ A;  3EZE A;  2BE5 D;  4HGV A;  4APA A;  3GTP A;  1EB4 A;  1IW7 D;  4EFC A;  1TWG A;  1J3U A;  2AQL A;  4ADL A;  1Y2M A;  3EZA A;  4CEH A;  1GK2 A;  2HRO A;  4MX2 A;  4NLE A;  1SMY D;  1EZB A;  4ADM A;  3KDY A;  1VDK A;  3C8T A;  3QBP A;  2JA6 A;  5M0J A;  4FBS A;  2RJR A;  2R92 A;  1XWO A;  2VSF A;  2OHY A;  2HVG A;  2MX9 A;  1DOF A;  3TV2 A;  3BHG A;  3LRD A;  5M0I A;  2NVY A;  1KQ7 A;  2PFM A;  1YFE A;  5F91 A;  1EZA A;  5D6B A;  1ZYM A;  2FUS A;  2NVX A;  2A6H D;  1TJV A;  3R6Y A;  1RE5 A;  3GTQ A;  1GKJ A;  3EZB A;  2J91 A;  3GTK A;  3OCF A;  4BAA A;  2EZB A;  2VL7 A;  2MP0 A;  1B8F A;  2QVE A;  3RRP A;  3H0G A;  1FUR A;  2X0P A;  2N3E A;  1TWF A;  3R6Q A;  4EEI A;  1HY1 A;  2YU9 A;  2LKM B;  4CEJ A;  2JA5 A;  5HW2 A;  1Y1W A;  1FUQ A;  1YNJ D;  1HY0 A;  4C5U A;  2EZC A;  2FIP A;  3LR2 A;  1K7W A;  1I3Q A;  1I0A A;  2B63 A;  2Y0N A;  3R6V A;  3LR8 A;  2O7B A;  1T6J A;  1TJW A;  2R7Z A;  5EYV A;  2YII A;  3KDZ A;  1R9T A;  4NSL A;  2K3O A;  3E04 A;  4FFX A;  2LTH A;  2O78 A;  2CW0 D;  4C5R A;  1I6V D;  1GK3 A; 
#chains in the Genus database with same CATH homology
 4V2R A;  1FUO A;  2NYN A;  3GZH A;  2PTS A;  3GTD A;  3CZO A;  4C5S A;  3RD8 A;  3UNV A;  4C6G A;  1Q5N A;  3NZ4 A;  1U15 A;  2O7E A;  1JSW A;  1U16 A;  2RJS A;  2VD6 A;  5F92 A;  3OCE A;  2NYF A;  1W27 A;  4V2Q A;  3NO9 A;  1GK3 A;  2E9F A;  2X75 A;  5EYT A;  1K62 A;  1FUP A;  1C3C A;  4FLC A;  1TJ7 A;  1DCN A;  1TJU A;  1YFM A;  2O7F A;  2PTR A;  1C3U A;  2O7D A;  1YIS A;  2QGA B;  1GKM A;  4BAB A;  1AUW A;  4CQ5 A;  4APB A;  2O6Y A;  1T6P A;  2PTQ A;  4HGV A;  4APA A;  1EB4 A;  4EFC A;  1J3U A;  4ADL A;  1Y2M A;  1GK2 A;  4MX2 A;  4NLE A;  4ADM A;  3KDY A;  1VDK A;  3C8T A;  3QBP A;  2RJR A;  1XWO A;  2OHY A;  2HVG A;  1DOF A;  3TV2 A;  3BHG A;  1KQ7 A;  2PFM A;  1YFE A;  5F91 A;  5D6B A;  3R6Y A;  2FUS A;  1TJV A;  1RE5 A;  1GKJ A;  2J91 A;  3OCF A;  4BAA A;  1B8F A;  2QVE A;  3RRP A;  1FUR A;  3R6Q A;  4EEI A;  5HW2 A;  1FUQ A;  1HY0 A;  4C5U A;  1K7W A;  1I0A A;  3R6V A;  2O7B A;  1T6J A;  1TJW A;  5EYV A;  2YII A;  3KDZ A;  4NSL A;  3E04 A;  4FFX A;  2O78 A;  4C5R A;  1HY1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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