4C5RA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 264
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
264
sequence length
667
structure length
634
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEACRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALTLVDRLAEFEKRLSDRLENEMTAVRVLYEVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE
total genus 264
structure length 634
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c5rA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c5rA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c5rA02
4NSLA 1Q5NA 1T6PA 1DOFA 1YFEA 5D6BA 1FUQA 4ADLA 4C5UA 1TJUA 1GK3A 4NLEA 4C6GA 2X75A 1TJ7A 5EYTA 4EEIA 5EYVA 1RE5A 2NYFA 2J91A 3C8TA 2PTSA 1GKJA 1GKMA 4C5SA 2E9FA 3R6VA 1W27A 2RJRA 3E04A 4V2RA 4BAAA 3R6YA 2NYNA 1DCNA 4FLCA 2PFMA 1B8FA 2O78A 3TV2A 1C3CA 4HGVA 1FUOA 5F91A 1EB4A 1C3UA 3OCFA 3GTDA 1FURA 2O7DA 1U16A 3GZHA 1HY1A 3UNVA 3OCEA 4FFXA 1T6JA 2QGAB 5F92A 3QBPA 2O7FA 1GK2A 2FUSA 3KDZA 1YISA 1JSWA 2RJSA 4MX2A 1AUWA 3NO9A 5HW2A 3KDYA 1VDKA 1YFMA 3R6QA 4ADMA 2O7EA 2PTRA 2OHYA 1TJVA 1K62A 1U15A 1KQ7A 4CQ5A 1J3UA 2VD6A 3BHGA 2QVEA 4BABA 4C5RA 3RRPA 3CZOA 1XWOA 4APAA 3RD8A 2HVGA 4EFCA 2YIIA 3NZ4A 1TJWA 1K7WA 4V2QA 1Y2MA 2O6YA 2PTQA 1I0AA 4APBA 2O7BA 1FUPA 1HY0A
chains in the Genus database with same CATH superfamily
4NSLA 2K3NA 1Q5NA 5M0IA 1T6PA 1DOFA 1I50A 1HQMD 1IW7D 1TWFA 1YFEA 5D6BA 1FUQA 1XL8A 4ADLA 1K83A 2E2IA 2YU9A 3LR6A 4C5UA 1Y1WA 1TJUA 4WNLA 1GK3A 4FBSA 4NLEA 4C6GA 2FIOA 2R7ZA 4CEHA 1TJ7A 1XL7A 3H0GA 2X75A 1WCMA 5EYTA 4EEIA 4CEIA 5M0JA 2LPJA 1SFOA 1RE5A 5EYVA 2AQLA 2NYFA 2MX9A 2B63A 3CRVA 2J91A 2EZAA 2HWGA 3EZAA 2PTSA 2VL7A 3C8TA 1ZYMA 2VSFA 1GKJA 2A6ED 2EZCA 1GKMA 4C5SA 3GTGA 3GTKA 2E9FA 3R6VA 1W27A 2A68D 2F5JA 2NVXA 2RJRA 4V2RA 4BAAA 3E04A 3LRDA 3R6YA 2NYNA 1Y1VA 3GTOA 3LR8A 2NVYA 2BE5D 3GTPA 2K3QA 1DCNA 2O5JD 2PFMA 1B8FA 4FLCA 2O78A 2LKMB 3TV2A 1C3CA 4HGVA 1FUOA 3GTLA 1XMDA 2MP0A 2E2HA 5F91A 1EB4A 3FKIA 1C3UA 3OCFA 2K3OA 2CW0D 2X0QA 3GTDA 1FURA 2O7DA 2JA7A 1U16A 3GZHA 1HY1A 3UNVA 3OCEA 3CRW1 4FFXA 2R93A 1T6JA 2QGAB 1XMCA 5F92A 3QBPA 4C2MA 2N1DB 2O7FA 5H8WA 1GK2A 2Y0NA 2FUSA 3KDZA 2JA5A 1YISA 3LR2A 1JSWA 2RJSA 4MX2A 1AUWA 3NO9A 3GTJA 2LPIA 3GTQA 2VUMA 3KDYA 2LYIA 1VDKA 1YFMA 3R6QA 5HW2A 1XLYA 4ADMA 2O7EA 2PTRA 2OHYA 1TWAA 1TJVA 3EZBA 1K62A 1U15A 1KQ7A 4CQ5A 1J3UA 2X0OA 1YNJD 2VD6A 3BHGA 1EZBA 2EZBA 2QVEA 3GTMA 1YNND 2FIPA 4BABA 4C5RA 3U4QA 3CZOA 3RRPA 3CQZA 1XWOA 1TWCA 2N3EA 1I6VD 3EZEA 4APAA 2MX8A 2FENA 4QIWA 3RD8A 2MQAA 4A15A 2HVGA 4EFCA 1TWHA 2YIIA 2A6HD 2JA6A 1TWGA 1SMYD 5IZ2A 3NZ4A 1TJWA 2HROA 1K7WA 4V2QA 3U44A 1Y2MA 2O6YA 2PTQA 1I3QA 1I0AA 2FELA 2R92A 2LTHA 4APBA 1EZAA 2O7BA 1ZYRD 1FUPA 2A69D 4CEJA 2VK9A 1HY0A 1R9TA 2X0PA
chains in the Genus database with same CATH topology
4NSLA 1Q5NA 1T6PA 1DOFA 1YFEA 5D6BA 1FUQA 4ADLA 4C5UA 1TJUA 1GK3A 4NLEA 4C6GA 2X75A 1TJ7A 5EYTA 4EEIA 5EYVA 1RE5A 2NYFA 2J91A 3C8TA 2PTSA 1GKJA 1GKMA 4C5SA 2E9FA 3R6VA 1W27A 2RJRA 3E04A 4V2RA 4BAAA 3R6YA 2NYNA 1DCNA 4FLCA 2PFMA 1B8FA 2O78A 3TV2A 1C3CA 4HGVA 1FUOA 5F91A 1EB4A 1C3UA 3OCFA 3GTDA 1FURA 2O7DA 1U16A 3GZHA 1HY1A 3UNVA 3OCEA 4FFXA 1T6JA 2QGAB 5F92A 3QBPA 2O7FA 1GK2A 2FUSA 3KDZA 1YISA 1JSWA 2RJSA 4MX2A 1AUWA 3NO9A 5HW2A 3KDYA 1VDKA 1YFMA 3R6QA 4ADMA 2O7EA 2PTRA 2OHYA 1TJVA 1K62A 1U15A 1KQ7A 4CQ5A 1J3UA 2VD6A 3BHGA 2QVEA 4BABA 4C5RA 3RRPA 3CZOA 1XWOA 4APAA 3RD8A 2HVGA 4EFCA 2YIIA 3NZ4A 1TJWA 1K7WA 4V2QA 1Y2MA 2O6YA 2PTQA 1I0AA 4APBA 2O7BA 1FUPA 1HY0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NSL A;  1Q5N A;  1T6P A;  1DOF A;  1YFE A;  5D6B A;  1FUQ A;  4ADL A;  4C5U A;  1TJU A;  1GK3 A;  4NLE A;  4C6G A;  2X75 A;  1TJ7 A;  5EYT A;  4EEI A;  5EYV A;  1RE5 A;  2NYF A;  2J91 A;  3C8T A;  2PTS A;  1GKJ A;  1GKM A;  4C5S A;  2E9F A;  3R6V A;  1W27 A;  2RJR A;  3E04 A;  4V2R A;  4BAA A;  3R6Y A;  2NYN A;  1DCN A;  4FLC A;  2PFM A;  1B8F A;  2O78 A;  3TV2 A;  1C3C A;  4HGV A;  1FUO A;  5F91 A;  1EB4 A;  1C3U A;  3OCF A;  3GTD A;  1FUR A;  2O7D A;  1U16 A;  3GZH A;  1HY1 A;  3UNV A;  3OCE A;  4FFX A;  1T6J A;  2QGA B;  5F92 A;  3QBP A;  2O7F A;  1GK2 A;  2FUS A;  3KDZ A;  1YIS A;  1JSW A;  2RJS A;  4MX2 A;  1AUW A;  3NO9 A;  5HW2 A;  3KDY A;  1VDK A;  1YFM A;  3R6Q A;  4ADM A;  2O7E A;  2PTR A;  2OHY A;  1TJV A;  1K62 A;  1U15 A;  1KQ7 A;  4CQ5 A;  1J3U A;  2VD6 A;  3BHG A;  2QVE A;  4BAB A;  4C5R A;  3RRP A;  3CZO A;  1XWO A;  4APA A;  3RD8 A;  2HVG A;  4EFC A;  2YII A;  3NZ4 A;  1TJW A;  1K7W A;  4V2Q A;  1Y2M A;  2O6Y A;  2PTQ A;  1I0A A;  4APB A;  2O7B A;  1FUP A;  1HY0 A; 
#chains in the Genus database with same CATH topology
 4NSL A;  2K3N A;  1Q5N A;  5M0I A;  1T6P A;  1DOF A;  1I50 A;  1HQM D;  1IW7 D;  1TWF A;  1YFE A;  5D6B A;  1FUQ A;  1XL8 A;  4ADL A;  1K83 A;  2E2I A;  2YU9 A;  3LR6 A;  4C5U A;  1Y1W A;  1TJU A;  4WNL A;  1GK3 A;  4FBS A;  4NLE A;  4C6G A;  2FIO A;  2R7Z A;  4CEH A;  1TJ7 A;  1XL7 A;  3H0G A;  2X75 A;  1WCM A;  5EYT A;  4EEI A;  4CEI A;  5M0J A;  2LPJ A;  1SFO A;  1RE5 A;  5EYV A;  2AQL A;  2NYF A;  2MX9 A;  2B63 A;  3CRV A;  2J91 A;  2EZA A;  2HWG A;  3EZA A;  2PTS A;  2VL7 A;  3C8T A;  1ZYM A;  2VSF A;  1GKJ A;  2A6E D;  2EZC A;  1GKM A;  4C5S A;  3GTG A;  3GTK A;  2E9F A;  3R6V A;  1W27 A;  2A68 D;  2F5J A;  2NVX A;  2RJR A;  4V2R A;  4BAA A;  3E04 A;  3LRD A;  3R6Y A;  2NYN A;  1Y1V A;  3GTO A;  3LR8 A;  2NVY A;  2BE5 D;  3GTP A;  2K3Q A;  1DCN A;  2O5J D;  2PFM A;  1B8F A;  4FLC A;  2O78 A;  2LKM B;  3TV2 A;  1C3C A;  4HGV A;  1FUO A;  3GTL A;  1XMD A;  2MP0 A;  2E2H A;  5F91 A;  1EB4 A;  3FKI A;  1C3U A;  3OCF A;  2K3O A;  2CW0 D;  2X0Q A;  3GTD A;  1FUR A;  2O7D A;  2JA7 A;  1U16 A;  3GZH A;  1HY1 A;  3UNV A;  3OCE A;  3CRW 1;  4FFX A;  2R93 A;  1T6J A;  2QGA B;  1XMC A;  5F92 A;  3QBP A;  4C2M A;  2N1D B;  2O7F A;  5H8W A;  1GK2 A;  2Y0N A;  2FUS A;  3KDZ A;  2JA5 A;  1YIS A;  3LR2 A;  1JSW A;  2RJS A;  4MX2 A;  1AUW A;  3NO9 A;  3GTJ A;  2LPI A;  3GTQ A;  2VUM A;  3KDY A;  2LYI A;  1VDK A;  1YFM A;  3R6Q A;  5HW2 A;  1XLY A;  4ADM A;  2O7E A;  2PTR A;  2OHY A;  1TWA A;  1TJV A;  3EZB A;  1K62 A;  1U15 A;  1KQ7 A;  4CQ5 A;  1J3U A;  2X0O A;  1YNJ D;  2VD6 A;  3BHG A;  1EZB A;  2EZB A;  2QVE A;  3GTM A;  1YNN D;  2FIP A;  4BAB A;  4C5R A;  3U4Q A;  3CZO A;  3RRP A;  3CQZ A;  1XWO A;  1TWC A;  2N3E A;  1I6V D;  3EZE A;  4APA A;  2MX8 A;  2FEN A;  4QIW A;  3RD8 A;  2MQA A;  4A15 A;  2HVG A;  4EFC A;  1TWH A;  2YII A;  2A6H D;  2JA6 A;  1TWG A;  1SMY D;  5IZ2 A;  3NZ4 A;  1TJW A;  2HRO A;  1K7W A;  4V2Q A;  3U44 A;  1Y2M A;  2O6Y A;  2PTQ A;  1I3Q A;  1I0A A;  2FEL A;  2R92 A;  2LTH A;  4APB A;  1EZA A;  2O7B A;  1ZYR D;  1FUP A;  2A69 D;  4CEJ A;  2VK9 A;  1HY0 A;  1R9T A;  2X0P A; 
#chains in the Genus database with same CATH homology
 4NSL A;  1Q5N A;  1T6P A;  1DOF A;  1YFE A;  5D6B A;  1FUQ A;  4ADL A;  4C5U A;  1TJU A;  1GK3 A;  4NLE A;  4C6G A;  2X75 A;  1TJ7 A;  5EYT A;  4EEI A;  5EYV A;  1RE5 A;  2NYF A;  2J91 A;  3C8T A;  2PTS A;  1GKJ A;  1GKM A;  4C5S A;  2E9F A;  3R6V A;  1W27 A;  2RJR A;  3E04 A;  4V2R A;  4BAA A;  3R6Y A;  2NYN A;  1DCN A;  4FLC A;  2PFM A;  1B8F A;  2O78 A;  3TV2 A;  1C3C A;  4HGV A;  1FUO A;  5F91 A;  1EB4 A;  1C3U A;  3OCF A;  3GTD A;  1FUR A;  2O7D A;  1U16 A;  3GZH A;  1HY1 A;  3UNV A;  3OCE A;  4FFX A;  1T6J A;  2QGA B;  5F92 A;  3QBP A;  2O7F A;  1GK2 A;  2FUS A;  3KDZ A;  1YIS A;  1JSW A;  2RJS A;  4MX2 A;  1AUW A;  3NO9 A;  5HW2 A;  3KDY A;  1VDK A;  1YFM A;  3R6Q A;  4ADM A;  2O7E A;  2PTR A;  2OHY A;  1TJV A;  1K62 A;  1U15 A;  1KQ7 A;  4CQ5 A;  1J3U A;  2VD6 A;  3BHG A;  2QVE A;  4BAB A;  4C5R A;  3RRP A;  3CZO A;  1XWO A;  4APA A;  3RD8 A;  2HVG A;  4EFC A;  2YII A;  3NZ4 A;  1TJW A;  1K7W A;  4V2Q A;  1Y2M A;  2O6Y A;  2PTQ A;  1I0A A;  4APB A;  2O7B A;  1FUP A;  1HY0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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