4C5RA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 264
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
264
sequence length
667
structure length
634
Chain Sequence
b'SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEACRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALTLVDRLAEFEKRLSDRLENEMTAVRVLYEVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMMONIA-LYASE
publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 264
structure length 634
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c5rA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c5rA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c5rA02
3CZOA 1U15A 4V2RA 2O7FA 2RJSA 5F91A 1TJWA 3R6VA 4C5UA 3E04A 1DCNA 1HY1A 4FFXA 5EYTA 2YIIA 2PTSA 4EEIA 3KDYA 3OCFA 5D6BA 1T6PA 5HW2A 1C3CA 4BAAA 1FUPA 2O78A 1HY0A 2QVEA 4FLCA 2RJRA 2PFMA 2O7BA 3NO9A 3TV2A 1TJVA 4EFCA 2O7EA 3KDZA 3RD8A 3RRPA 5EYVA 1FUQA 3R6YA 2VD6A 1XWOA 2J91A 1FUOA 2QGAB 1K7WA 4V2QA 1U16A 4C5SA 3R6QA 3BHGA 4MX2A 1AUWA 2O7DA 2X75A 1VDKA 1YFMA 1Q5NA 1FURA 1GKJA 4HGVA 1B8FA 3GZHA 4APAA 2PTRA 4NSLA 3NZ4A 2NYNA 1I0AA 1TJUA 4CQ5A 1GK2A 4BABA 1EB4A 2PTQA 3UNVA 1K62A 1YFEA 1GKMA 1TJ7A 4C5RA 4APBA 1RE5A 2HVGA 3GTDA 3OCEA 1DOFA 1JSWA 1C3UA 3QBPA 1T6JA 1YISA 4ADLA 4C6GA 1W27A 2FUSA 3C8TA 1Y2MA 2OHYA 4ADMA 1GK3A 2NYFA 5F92A 2E9FA 4NLEA 1KQ7A 1J3UA 2O6YA
chains in the Genus database with same CATH superfamily
3CZOA 3LR6A 1U15A 1XMCA 4V2RA 2O7FA 2RJSA 5F91A 1TJWA 2Y0NA 3R6VA 2LYIA 4C5UA 3LR2A 2VSFA 3E04A 2A6ED 1DCNA 1HY1A 4FFXA 5EYTA 2YIIA 1XL7A 2PTSA 4EEIA 3KDYA 1XMDA 2HROA 3OCFA 5M0JA 5D6BA 1SMYD 3CQZA 2FIOA 1EZAA 1XL8A 1T6PA 3CRVA 2R93A 5H8WA 3GTKA 2EZBA 5HW2A 1K83A 1C3CA 2N1DB 2JA5A 4BAAA 1FUPA 2O78A 1HY0A 2QVEA 2R92A 4FLCA 2RJRA 3LRDA 2PFMA 2O7BA 2JA6A 3NO9A 3TV2A 1TWHA 1TJVA 3GTQA 2MX9A 1YNND 2VL7A 2FIPA 4EFCA 2O7EA 3KDZA 1Y1WA 3RD8A 3U44A 2K3NA 4CEIA 2AQLA 2X0PA 3GTPA 3RRPA 2JA7A 1R9TA 5EYVA 3LR8A 1FUQA 2MX8A 2O6YA 3R6YA 2VD6A 1TWFA 1XWOA 2LKMB 2J91A 2NVXA 1FUOA 2K3QA 3GTGA 2R7ZA 2HWGA 2QGAB 4CEJA 2E2IA 1IW7D 2BE5D 4QIWA 1K7WA 4V2QA 1U16A 4C5SA 2N3EA 1WCMA 2O5JD 3R6QA 3BHGA 4MX2A 1AUWA 3GTMA 2O7DA 2X75A 1VDKA 2CW0D 1YFMA 1Q5NA 1FURA 1GKJA 4HGVA 1B8FA 2VK9A 3GZHA 2E2HA 2A69D 4APAA 1Y1VA 2A6HD 2PTRA 4NSLA 3NZ4A 2X0QA 2NYNA 1I0AA 1TJUA 1TWAA 4A15A 3GTJA 2MQAA 3EZAA 4CEHA 4C2MA 1TWGA 2MP0A 4CQ5A 1GK2A 4BABA 1EB4A 2PTQA 3UNVA 1K62A 2YU9A 1I6VD 2F5JA 5IZ2A 1I3QA 1YFEA 1GKMA 2FENA 2NVYA 2LTHA 1TJ7A 4C5RA 4APBA 1XLYA 1RE5A 2HVGA 2VUMA 3GTDA 3OCEA 2LPIA 1TWCA 1DOFA 1JSWA 1C3UA 3CRW1 1YNJD 3QBPA 1I50A 1ZYMA 1T6JA 2FELA 2X0OA 1YISA 2B63A 4ADLA 1ZYRD 3FKIA 1HQMD 4C6GA 1W27A 3GTOA 3U4QA 3H0GA 2FUSA 3C8TA 1Y2MA 2EZAA 4WNLA 2OHYA 4ADMA 2K3OA 1GK3A 2NYFA 3EZEA 5F92A 2E9FA 1EZBA 3GTLA 4NLEA 1KQ7A 1J3UA 2EZCA 1SFOA 2A68D 2LPJA 3EZBA 4FBSA 5M0IA
chains in the Genus database with same CATH topology
3CZOA 1U15A 4V2RA 2O7FA 2RJSA 5F91A 1TJWA 3R6VA 4C5UA 3E04A 1DCNA 1HY1A 4FFXA 5EYTA 2YIIA 2PTSA 4EEIA 3KDYA 3OCFA 5D6BA 1T6PA 5HW2A 1C3CA 4BAAA 1FUPA 2O78A 1HY0A 2QVEA 4FLCA 2RJRA 2PFMA 2O7BA 3NO9A 3TV2A 1TJVA 4EFCA 2O7EA 3KDZA 3RD8A 3RRPA 5EYVA 1FUQA 3R6YA 2VD6A 1XWOA 2J91A 1FUOA 2QGAB 1K7WA 4V2QA 1U16A 4C5SA 3R6QA 3BHGA 4MX2A 1AUWA 2O7DA 2X75A 1VDKA 1YFMA 1Q5NA 1FURA 1GKJA 4HGVA 1B8FA 3GZHA 4APAA 2PTRA 4NSLA 3NZ4A 2NYNA 1I0AA 1TJUA 4CQ5A 1GK2A 4BABA 1EB4A 2PTQA 3UNVA 1K62A 1YFEA 1GKMA 1TJ7A 4C5RA 4APBA 1RE5A 2HVGA 3GTDA 3OCEA 1DOFA 1JSWA 1C3UA 3QBPA 1T6JA 1YISA 4ADLA 4C6GA 1W27A 2FUSA 3C8TA 1Y2MA 2OHYA 4ADMA 1GK3A 2NYFA 5F92A 2E9FA 4NLEA 1KQ7A 1J3UA 2O6YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CZO A;  1U15 A;  4V2R A;  2O7F A;  2RJS A;  5F91 A;  1TJW A;  3R6V A;  4C5U A;  3E04 A;  1DCN A;  1HY1 A;  4FFX A;  5EYT A;  2YII A;  2PTS A;  4EEI A;  3KDY A;  3OCF A;  5D6B A;  1T6P A;  5HW2 A;  1C3C A;  4BAA A;  1FUP A;  2O78 A;  1HY0 A;  2QVE A;  4FLC A;  2RJR A;  2PFM A;  2O7B A;  3NO9 A;  3TV2 A;  1TJV A;  4EFC A;  2O7E A;  3KDZ A;  3RD8 A;  3RRP A;  5EYV A;  1FUQ A;  3R6Y A;  2VD6 A;  1XWO A;  2J91 A;  1FUO A;  2QGA B;  1K7W A;  4V2Q A;  1U16 A;  4C5S A;  3R6Q A;  3BHG A;  4MX2 A;  1AUW A;  2O7D A;  2X75 A;  1VDK A;  1YFM A;  1Q5N A;  1FUR A;  1GKJ A;  4HGV A;  1B8F A;  3GZH A;  4APA A;  2PTR A;  4NSL A;  3NZ4 A;  2NYN A;  1I0A A;  1TJU A;  4CQ5 A;  1GK2 A;  4BAB A;  1EB4 A;  2PTQ A;  3UNV A;  1K62 A;  1YFE A;  1GKM A;  1TJ7 A;  4C5R A;  4APB A;  1RE5 A;  2HVG A;  3GTD A;  3OCE A;  1DOF A;  1JSW A;  1C3U A;  3QBP A;  1T6J A;  1YIS A;  4ADL A;  4C6G A;  1W27 A;  2FUS A;  3C8T A;  1Y2M A;  2OHY A;  4ADM A;  1GK3 A;  2NYF A;  5F92 A;  2E9F A;  4NLE A;  1KQ7 A;  1J3U A;  2O6Y A; 
#chains in the Genus database with same CATH topology
 3CZO A;  3LR6 A;  1U15 A;  1XMC A;  4V2R A;  2O7F A;  2RJS A;  5F91 A;  1TJW A;  2Y0N A;  3R6V A;  2LYI A;  4C5U A;  3LR2 A;  2VSF A;  3E04 A;  2A6E D;  1DCN A;  1HY1 A;  4FFX A;  5EYT A;  2YII A;  1XL7 A;  2PTS A;  4EEI A;  3KDY A;  1XMD A;  2HRO A;  3OCF A;  5M0J A;  5D6B A;  1SMY D;  3CQZ A;  2FIO A;  1EZA A;  1XL8 A;  1T6P A;  3CRV A;  2R93 A;  5H8W A;  3GTK A;  2EZB A;  5HW2 A;  1K83 A;  1C3C A;  2N1D B;  2JA5 A;  4BAA A;  1FUP A;  2O78 A;  1HY0 A;  2QVE A;  2R92 A;  4FLC A;  2RJR A;  3LRD A;  2PFM A;  2O7B A;  2JA6 A;  3NO9 A;  3TV2 A;  1TWH A;  1TJV A;  3GTQ A;  2MX9 A;  1YNN D;  2VL7 A;  2FIP A;  4EFC A;  2O7E A;  3KDZ A;  1Y1W A;  3RD8 A;  3U44 A;  2K3N A;  4CEI A;  2AQL A;  2X0P A;  3GTP A;  3RRP A;  2JA7 A;  1R9T A;  5EYV A;  3LR8 A;  1FUQ A;  2MX8 A;  2O6Y A;  3R6Y A;  2VD6 A;  1TWF A;  1XWO A;  2LKM B;  2J91 A;  2NVX A;  1FUO A;  2K3Q A;  3GTG A;  2R7Z A;  2HWG A;  2QGA B;  4CEJ A;  2E2I A;  1IW7 D;  2BE5 D;  4QIW A;  1K7W A;  4V2Q A;  1U16 A;  4C5S A;  2N3E A;  1WCM A;  2O5J D;  3R6Q A;  3BHG A;  4MX2 A;  1AUW A;  3GTM A;  2O7D A;  2X75 A;  1VDK A;  2CW0 D;  1YFM A;  1Q5N A;  1FUR A;  1GKJ A;  4HGV A;  1B8F A;  2VK9 A;  3GZH A;  2E2H A;  2A69 D;  4APA A;  1Y1V A;  2A6H D;  2PTR A;  4NSL A;  3NZ4 A;  2X0Q A;  2NYN A;  1I0A A;  1TJU A;  1TWA A;  4A15 A;  3GTJ A;  2MQA A;  3EZA A;  4CEH A;  4C2M A;  1TWG A;  2MP0 A;  4CQ5 A;  1GK2 A;  4BAB A;  1EB4 A;  2PTQ A;  3UNV A;  1K62 A;  2YU9 A;  1I6V D;  2F5J A;  5IZ2 A;  1I3Q A;  1YFE A;  1GKM A;  2FEN A;  2NVY A;  2LTH A;  1TJ7 A;  4C5R A;  4APB A;  1XLY A;  1RE5 A;  2HVG A;  2VUM A;  3GTD A;  3OCE A;  2LPI A;  1TWC A;  1DOF A;  1JSW A;  1C3U A;  3CRW 1;  1YNJ D;  3QBP A;  1I50 A;  1ZYM A;  1T6J A;  2FEL A;  2X0O A;  1YIS A;  2B63 A;  4ADL A;  1ZYR D;  3FKI A;  1HQM D;  4C6G A;  1W27 A;  3GTO A;  3U4Q A;  3H0G A;  2FUS A;  3C8T A;  1Y2M A;  2EZA A;  4WNL A;  2OHY A;  4ADM A;  2K3O A;  1GK3 A;  2NYF A;  3EZE A;  5F92 A;  2E9F A;  1EZB A;  3GTL A;  4NLE A;  1KQ7 A;  1J3U A;  2EZC A;  1SFO A;  2A68 D;  2LPJ A;  3EZB A;  4FBS A;  5M0I A; 
#chains in the Genus database with same CATH homology
 3CZO A;  1U15 A;  4V2R A;  2O7F A;  2RJS A;  5F91 A;  1TJW A;  3R6V A;  4C5U A;  3E04 A;  1DCN A;  1HY1 A;  4FFX A;  5EYT A;  2YII A;  2PTS A;  4EEI A;  3KDY A;  3OCF A;  5D6B A;  1T6P A;  5HW2 A;  1C3C A;  4BAA A;  1FUP A;  2O78 A;  1HY0 A;  2QVE A;  4FLC A;  2RJR A;  2PFM A;  2O7B A;  3NO9 A;  3TV2 A;  1TJV A;  4EFC A;  2O7E A;  3KDZ A;  3RD8 A;  3RRP A;  5EYV A;  1FUQ A;  3R6Y A;  2VD6 A;  1XWO A;  2J91 A;  1FUO A;  2QGA B;  1K7W A;  4V2Q A;  1U16 A;  4C5S A;  3R6Q A;  3BHG A;  4MX2 A;  1AUW A;  2O7D A;  2X75 A;  1VDK A;  1YFM A;  1Q5N A;  1FUR A;  1GKJ A;  4HGV A;  1B8F A;  3GZH A;  4APA A;  2PTR A;  4NSL A;  3NZ4 A;  2NYN A;  1I0A A;  1TJU A;  4CQ5 A;  1GK2 A;  4BAB A;  1EB4 A;  2PTQ A;  3UNV A;  1K62 A;  1YFE A;  1GKM A;  1TJ7 A;  4C5R A;  4APB A;  1RE5 A;  2HVG A;  3GTD A;  3OCE A;  1DOF A;  1JSW A;  1C3U A;  3QBP A;  1T6J A;  1YIS A;  4ADL A;  4C6G A;  1W27 A;  2FUS A;  3C8T A;  1Y2M A;  2OHY A;  4ADM A;  1GK3 A;  2NYF A;  5F92 A;  2E9F A;  4NLE A;  1KQ7 A;  1J3U A;  2O6Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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