1W27A

Phenylalanine ammonia-lyase (pal) from petroselinum crispum
Total Genus 254
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
254
sequence length
690
structure length
689
Chain Sequence
EDPLYWGIAAEAMTGSHLDEVKKMVAEYRKPVVKLGGETLTISQVAAISARDGSGVTVELSEAARAGVKASSDWVMDSMNKGTDSYGVTTGFGATSHRRTKQGGALQKELIRFLNAGIFGNGSDNTLPHSATRAAMLVRINTLLQGYSGIRFEILEAITKFLNQNITPCLPLRGTITDLVPLSYIAGLLTGRPNSKAVGPTGVILSPEEAFKLAGVEGGFFELQPKEGLALVNGTAVGSGMASMVLFEANILAVLAEVMSAIFAEVMQGKPEFTDHLTHKLKHHPGQIEAAAIMEHILDGSAYVKAAQKLHEMDPLQKPKQDRYALRTSPQWLGPQIEVIRSSTKMIEREINSVNDNPLIDVSRNKAIHGGNFQGTPIGVSMDNTRLAIAAIGKLMFAQFSELVNDFYNNGLPSNLSGGRNPSLDYGFKGAEIAMASYCSELQFLANPVTNHVQSAEQHNQDVNSLGLISSRKTSEAVEILKLMSTTFLVGLCQAIDLRHLEENLKSTVKNTVSSVAKRVLTMGVNGELHPSRFCEKDLLRVVDREYIFAYIDDPCSATYPLMQKLRQTLVEHALKNGDNERNLSTSIFQKIATFEDELKALLPKEVESARAALESGNPAIPNRIEECRSYPLYKFVRKELGTEYLTGEKVTSPGEEFEKVFIAMSKGEIIDPLLECLESWNGAPLPIC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for the Entrance Into the Phenylpropanoid Metabolism Catalyzed by Phenylalanine Ammonia-Lyase
pubmed doi rcsb
source organism Petroselinum crispum
molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE 1
total genus 254
structure length 689
sequence length 690
chains with identical sequence B
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2004-06-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1w27A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1w27A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1w27A02
5EYTA 2HVGA 3R6YA 1EB4A 1K62A 5F91A 1GK2A 1YFMA 5HW2A 1J3UA 2X75A 1FUOA 2E9FA 4APBA 3GZHA 1TJWA 2RJSA 4EFCA 3KDYA 1C3CA 1GKMA 1KQ7A 3QBPA 3E04A 1FURA 1T6JA 3CZOA 1HY0A 1DOFA 2YIIA 4BAAA 1T6PA 1K7WA 3TV2A 1DCNA 4FLCA 2O7DA 1GKJA 3NZ4A 2OHYA 1YFEA 1XWOA 3KDZA 3BHGA 1Q5NA 2O7FA 2O78A 1U16A 2NYFA 4C6GA 4C5UA 3RRPA 2O7BA 4EEIA 3RD8A 1FUQA 2PTSA 5F92A 4ADLA 2PTRA 2FUSA 4MX2A 4C5RA 4ADMA 2J91A 4NSLA 1U15A 1YISA 1RE5A 1TJVA 3NO9A 2QGAB 4HGVA 2PTQA 5D6BA 1HY1A 1FUPA 4V2QA 2VD6A 2QVEA 1VDKA 3GTDA 3R6QA 4BABA 2O6YA 1JSWA 3R6VA 3OCEA 4V2RA 1GK3A 5EYVA 1TJUA 4CQ5A 4NLEA 1TJ7A 4FFXA 1W27A 1AUWA 2NYNA 3UNVA 1Y2MA 2PFMA 1C3UA 4APAA 2RJRA 3C8TA 1B8FA 3OCFA 4C5SA 2O7EA 1I0AA
chains in the Genus database with same CATH superfamily
5EYTA 3GTPA 1XMCA 2FIOA 2HVGA 3R6YA 1EB4A 1K62A 5F91A 1GK2A 2O5JD 1YFMA 2Y0NA 3LR8A 5HW2A 1J3UA 1YNJD 2X75A 1SFOA 1FUOA 2VUMA 2K3QA 2F5JA 2JA5A 2E9FA 1HQMD 2N3EA 2BE5D 4FBSA 1TWCA 1Y1VA 2MQAA 3LRDA 3GTOA 2JA7A 4APBA 1XL7A 3GZHA 1TJWA 2RJSA 2FELA 4EFCA 2FENA 1C3CA 3U44A 1ZYRD 1GKMA 3KDYA 1KQ7A 2AQLA 1YNND 4C2MA 3QBPA 1XLYA 3E04A 1XMDA 3U4QA 1FURA 1T6JA 3GTMA 1HY0A 3CZOA 2YU9A 1DOFA 2YIIA 4BAAA 1I6VD 1T6PA 2A68D 1K7WA 4WNLA 2JA6A 2X0PA 3TV2A 2X0OA 1DCNA 1EZAA 4FLCA 4CEHA 1TWFA 2O7DA 1EZBA 1GKJA 1TWAA 3NZ4A 2R7ZA 2OHYA 1YFEA 4CEIA 1XWOA 3KDZA 3BHGA 3EZBA 3LR2A 2R92A 1Q5NA 2O7FA 2X0QA 2O78A 1U16A 2LPIA 3GTGA 2NYFA 4C6GA 2E2HA 4C5UA 3RRPA 2O7BA 2R93A 4EEIA 2LPJA 3RD8A 3GTKA 2A69D 2LYIA 2NVYA 1FUQA 3LR6A 1I0AA 2PTSA 2B63A 2CW0D 5F92A 2K3NA 3GTQA 4ADLA 2NVXA 2PTRA 3GTJA 2FUSA 4MX2A 4C5RA 4ADMA 1Y1WA 2J91A 2HWGA 4NSLA 1U15A 1YISA 1RE5A 1TJVA 1I3QA 3GTLA 3NO9A 2VK9A 2QGAB 1K83A 5H8WA 3EZAA 1IW7D 4HGVA 2PTQA 5D6BA 1HY1A 3CRVA 1FUPA 3FKIA 4V2QA 1XL8A 5M0JA 2VD6A 2QVEA 1VDKA 3GTDA 4CEJA 3R6QA 2A6HD 1SMYD 2MP0A 4BABA 2O6YA 2LKMB 2E2IA 1JSWA 5M0IA 2K3OA 2N1DB 4QIWA 1TWHA 3R6VA 3OCEA 5IZ2A 4A15A 4V2RA 1GK3A 2FIPA 5EYVA 1TJUA 4CQ5A 3EZEA 4NLEA 2MX9A 1TJ7A 3CRW1 4FFXA 1TWGA 1W27A 2VSFA 2EZAA 3H0GA 2A6ED 1ZYMA 1AUWA 2MX8A 2NYNA 3UNVA 1Y2MA 3CQZA 2LTHA 2EZBA 2PFMA 1WCMA 1C3UA 4APAA 2RJRA 3C8TA 2EZCA 1B8FA 2VL7A 4C5SA 3OCFA 1R9TA 2O7EA 1I50A 2HROA
chains in the Genus database with same CATH topology
5EYTA 2HVGA 3R6YA 1EB4A 1K62A 5F91A 1GK2A 1YFMA 5HW2A 1J3UA 2X75A 1FUOA 2E9FA 4APBA 3GZHA 1TJWA 2RJSA 4EFCA 3KDYA 1C3CA 1GKMA 1KQ7A 3QBPA 3E04A 1FURA 1T6JA 3CZOA 1HY0A 1DOFA 2YIIA 4BAAA 1T6PA 1K7WA 3TV2A 1DCNA 4FLCA 2O7DA 1GKJA 3NZ4A 2OHYA 1YFEA 1XWOA 3KDZA 3BHGA 1Q5NA 2O7FA 2O78A 1U16A 2NYFA 4C6GA 4C5UA 3RRPA 2O7BA 4EEIA 3RD8A 1FUQA 2PTSA 5F92A 4ADLA 2PTRA 2FUSA 4MX2A 4C5RA 4ADMA 2J91A 4NSLA 1U15A 1YISA 1RE5A 1TJVA 3NO9A 2QGAB 4HGVA 2PTQA 5D6BA 1HY1A 1FUPA 4V2QA 2VD6A 2QVEA 1VDKA 3GTDA 3R6QA 4BABA 2O6YA 1JSWA 3R6VA 3OCEA 4V2RA 1GK3A 5EYVA 1TJUA 4CQ5A 4NLEA 1TJ7A 4FFXA 1W27A 1AUWA 2NYNA 3UNVA 1Y2MA 2PFMA 1C3UA 4APAA 2RJRA 3C8TA 1B8FA 3OCFA 4C5SA 2O7EA 1I0AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5EYT A;  2HVG A;  3R6Y A;  1EB4 A;  1K62 A;  5F91 A;  1GK2 A;  1YFM A;  5HW2 A;  1J3U A;  2X75 A;  1FUO A;  2E9F A;  4APB A;  3GZH A;  1TJW A;  2RJS A;  4EFC A;  3KDY A;  1C3C A;  1GKM A;  1KQ7 A;  3QBP A;  3E04 A;  1FUR A;  1T6J A;  3CZO A;  1HY0 A;  1DOF A;  2YII A;  4BAA A;  1T6P A;  1K7W A;  3TV2 A;  1DCN A;  4FLC A;  2O7D A;  1GKJ A;  3NZ4 A;  2OHY A;  1YFE A;  1XWO A;  3KDZ A;  3BHG A;  1Q5N A;  2O7F A;  2O78 A;  1U16 A;  2NYF A;  4C6G A;  4C5U A;  3RRP A;  2O7B A;  4EEI A;  3RD8 A;  1FUQ A;  2PTS A;  5F92 A;  4ADL A;  2PTR A;  2FUS A;  4MX2 A;  4C5R A;  4ADM A;  2J91 A;  4NSL A;  1U15 A;  1YIS A;  1RE5 A;  1TJV A;  3NO9 A;  2QGA B;  4HGV A;  2PTQ A;  5D6B A;  1HY1 A;  1FUP A;  4V2Q A;  2VD6 A;  2QVE A;  1VDK A;  3GTD A;  3R6Q A;  4BAB A;  2O6Y A;  1JSW A;  3R6V A;  3OCE A;  4V2R A;  1GK3 A;  5EYV A;  1TJU A;  4CQ5 A;  4NLE A;  1TJ7 A;  4FFX A;  1W27 A;  1AUW A;  2NYN A;  3UNV A;  1Y2M A;  2PFM A;  1C3U A;  4APA A;  2RJR A;  3C8T A;  1B8F A;  3OCF A;  4C5S A;  2O7E A;  1I0A A; 
#chains in the Genus database with same CATH topology
 5EYT A;  3GTP A;  1XMC A;  2FIO A;  2HVG A;  3R6Y A;  1EB4 A;  1K62 A;  5F91 A;  1GK2 A;  2O5J D;  1YFM A;  2Y0N A;  3LR8 A;  5HW2 A;  1J3U A;  1YNJ D;  2X75 A;  1SFO A;  1FUO A;  2VUM A;  2K3Q A;  2F5J A;  2JA5 A;  2E9F A;  1HQM D;  2N3E A;  2BE5 D;  4FBS A;  1TWC A;  1Y1V A;  2MQA A;  3LRD A;  3GTO A;  2JA7 A;  4APB A;  1XL7 A;  3GZH A;  1TJW A;  2RJS A;  2FEL A;  4EFC A;  2FEN A;  1C3C A;  3U44 A;  1ZYR D;  1GKM A;  3KDY A;  1KQ7 A;  2AQL A;  1YNN D;  4C2M A;  3QBP A;  1XLY A;  3E04 A;  1XMD A;  3U4Q A;  1FUR A;  1T6J A;  3GTM A;  1HY0 A;  3CZO A;  2YU9 A;  1DOF A;  2YII A;  4BAA A;  1I6V D;  1T6P A;  2A68 D;  1K7W A;  4WNL A;  2JA6 A;  2X0P A;  3TV2 A;  2X0O A;  1DCN A;  1EZA A;  4FLC A;  4CEH A;  1TWF A;  2O7D A;  1EZB A;  1GKJ A;  1TWA A;  3NZ4 A;  2R7Z A;  2OHY A;  1YFE A;  4CEI A;  1XWO A;  3KDZ A;  3BHG A;  3EZB A;  3LR2 A;  2R92 A;  1Q5N A;  2O7F A;  2X0Q A;  2O78 A;  1U16 A;  2LPI A;  3GTG A;  2NYF A;  4C6G A;  2E2H A;  4C5U A;  3RRP A;  2O7B A;  2R93 A;  4EEI A;  2LPJ A;  3RD8 A;  3GTK A;  2A69 D;  2LYI A;  2NVY A;  1FUQ A;  3LR6 A;  1I0A A;  2PTS A;  2B63 A;  2CW0 D;  5F92 A;  2K3N A;  3GTQ A;  4ADL A;  2NVX A;  2PTR A;  3GTJ A;  2FUS A;  4MX2 A;  4C5R A;  4ADM A;  1Y1W A;  2J91 A;  2HWG A;  4NSL A;  1U15 A;  1YIS A;  1RE5 A;  1TJV A;  1I3Q A;  3GTL A;  3NO9 A;  2VK9 A;  2QGA B;  1K83 A;  5H8W A;  3EZA A;  1IW7 D;  4HGV A;  2PTQ A;  5D6B A;  1HY1 A;  3CRV A;  1FUP A;  3FKI A;  4V2Q A;  1XL8 A;  5M0J A;  2VD6 A;  2QVE A;  1VDK A;  3GTD A;  4CEJ A;  3R6Q A;  2A6H D;  1SMY D;  2MP0 A;  4BAB A;  2O6Y A;  2LKM B;  2E2I A;  1JSW A;  5M0I A;  2K3O A;  2N1D B;  4QIW A;  1TWH A;  3R6V A;  3OCE A;  5IZ2 A;  4A15 A;  4V2R A;  1GK3 A;  2FIP A;  5EYV A;  1TJU A;  4CQ5 A;  3EZE A;  4NLE A;  2MX9 A;  1TJ7 A;  3CRW 1;  4FFX A;  1TWG A;  1W27 A;  2VSF A;  2EZA A;  3H0G A;  2A6E D;  1ZYM A;  1AUW A;  2MX8 A;  2NYN A;  3UNV A;  1Y2M A;  3CQZ A;  2LTH A;  2EZB A;  2PFM A;  1WCM A;  1C3U A;  4APA A;  2RJR A;  3C8T A;  2EZC A;  1B8F A;  2VL7 A;  4C5S A;  3OCF A;  1R9T A;  2O7E A;  1I50 A;  2HRO A; 
#chains in the Genus database with same CATH homology
 5EYT A;  2HVG A;  3R6Y A;  1EB4 A;  1K62 A;  5F91 A;  1GK2 A;  1YFM A;  5HW2 A;  1J3U A;  2X75 A;  1FUO A;  2E9F A;  4APB A;  3GZH A;  1TJW A;  2RJS A;  4EFC A;  3KDY A;  1C3C A;  1GKM A;  1KQ7 A;  3QBP A;  3E04 A;  1FUR A;  1T6J A;  3CZO A;  1HY0 A;  1DOF A;  2YII A;  4BAA A;  1T6P A;  1K7W A;  3TV2 A;  1DCN A;  4FLC A;  2O7D A;  1GKJ A;  3NZ4 A;  2OHY A;  1YFE A;  1XWO A;  3KDZ A;  3BHG A;  1Q5N A;  2O7F A;  2O78 A;  1U16 A;  2NYF A;  4C6G A;  4C5U A;  3RRP A;  2O7B A;  4EEI A;  3RD8 A;  1FUQ A;  2PTS A;  5F92 A;  4ADL A;  2PTR A;  2FUS A;  4MX2 A;  4C5R A;  4ADM A;  2J91 A;  4NSL A;  1U15 A;  1YIS A;  1RE5 A;  1TJV A;  3NO9 A;  2QGA B;  4HGV A;  2PTQ A;  5D6B A;  1HY1 A;  1FUP A;  4V2Q A;  2VD6 A;  2QVE A;  1VDK A;  3GTD A;  3R6Q A;  4BAB A;  2O6Y A;  1JSW A;  3R6V A;  3OCE A;  4V2R A;  1GK3 A;  5EYV A;  1TJU A;  4CQ5 A;  4NLE A;  1TJ7 A;  4FFX A;  1W27 A;  1AUW A;  2NYN A;  3UNV A;  1Y2M A;  2PFM A;  1C3U A;  4APA A;  2RJR A;  3C8T A;  1B8F A;  3OCF A;  4C5S A;  2O7E A;  1I0A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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