1W27A

Phenylalanine ammonia-lyase (pal) from petroselinum crispum
Total Genus 254
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
254
sequence length
690
structure length
689
Chain Sequence
EDPLYWGIAAEAMTGSHLDEVKKMVAEYRKPVVKLGGETLTISQVAAISARDGSGVTVELSEAARAGVKASSDWVMDSMNKGTDSYGVTTGFGATSHRRTKQGGALQKELIRFLNAGIFGNGSDNTLPHSATRAAMLVRINTLLQGYSGIRFEILEAITKFLNQNITPCLPLRGTITDLVPLSYIAGLLTGRPNSKAVGPTGVILSPEEAFKLAGVEGGFFELQPKEGLALVNGTAVGSGMASMVLFEANILAVLAEVMSAIFAEVMQGKPEFTDHLTHKLKHHPGQIEAAAIMEHILDGSAYVKAAQKLHEMDPLQKPKQDRYALRTSPQWLGPQIEVIRSSTKMIEREINSVNDNPLIDVSRNKAIHGGNFQGTPIGVSMDNTRLAIAAIGKLMFAQFSELVNDFYNNGLPSNLSGGRNPSLDYGFKGAEIAMASYCSELQFLANPVTNHVQSAEQHNQDVNSLGLISSRKTSEAVEILKLMSTTFLVGLCQAIDLRHLEENLKSTVKNTVSSVAKRVLTMGVNGELHPSRFCEKDLLRVVDREYIFAYIDDPCSATYPLMQKLRQTLVEHALKNGDNERNLSTSIFQKIATFEDELKALLPKEVESARAALESGNPAIPNRIEECRSYPLYKFVRKELGTEYLTGEKVTSPGEEFEKVFIAMSKGEIIDPLLECLESWNGAPLPIC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for the Entrance Into the Phenylpropanoid Metabolism Catalyzed by Phenylalanine Ammonia-Lyase
pubmed doi rcsb
source organism Petroselinum crispum
molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE 1
total genus 254
structure length 689
sequence length 690
chains with identical sequence B
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2004-06-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1w27A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1w27A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1w27A02
4EEIA 5EYTA 1K7WA 1DOFA 2HVGA 4FFXA 2YIIA 1TJUA 2PTQA 3OCEA 2PTRA 3R6YA 4C6GA 4C5UA 4NLEA 5D6BA 1T6PA 3KDZA 4V2QA 2O7EA 1FUQA 4MX2A 1KQ7A 1GK3A 1U16A 2VD6A 4V2RA 3R6VA 3UNVA 1GKJA 1Y2MA 1C3CA 3NO9A 3E04A 2NYNA 4BABA 1FUOA 3GZHA 4BAAA 1GKMA 4C5SA 1Q5NA 3R6QA 2O78A 1B8FA 3RD8A 1J3UA 1U15A 1JSWA 1TJWA 4EFCA 2PFMA 4APAA 2QVEA 1AUWA 4FLCA 5HW2A 1C3UA 5F92A 2RJRA 1RE5A 1DCNA 2J91A 2NYFA 4C5RA 2O7FA 2PTSA 1EB4A 1FURA 1VDKA 2O7DA 4ADLA 2X75A 1TJ7A 1YFEA 3OCFA 2RJSA 1FUPA 3C8TA 1I0AA 3QBPA 2OHYA 1T6JA 5F91A 3NZ4A 4ADMA 4APBA 4HGVA 1K62A 2FUSA 1W27A 1XWOA 1YFMA 1GK2A 2O7BA 5EYVA 3GTDA 1HY1A 2QGAB 3RRPA 2O6YA 3KDYA 3BHGA 2E9FA 3TV2A 1HY0A 4CQ5A 3CZOA 4NSLA 1YISA 1TJVA
chains in the Genus database with same CATH superfamily
4EEIA 3LR6A 5EYTA 1K7WA 1HQMD 4A15A 3GTPA 1DOFA 3GTKA 2HVGA 2X0PA 2YIIA 4FFXA 4WNLA 1TJUA 2PTQA 1XLYA 3LRDA 2A69D 3LR2A 3CRVA 3OCEA 3EZBA 2PTRA 2R93A 4C6GA 3R6YA 2FELA 4C5UA 2HROA 3U44A 2CW0D 3GTOA 1TWFA 2E2HA 2R7ZA 2JA5A 1TWCA 4NLEA 3EZAA 3LR8A 5D6BA 3H0GA 1Y1WA 2LYIA 1T6PA 2VK9A 3KDZA 1TWGA 2YU9A 4V2QA 1SMYD 2O7EA 2FIOA 2NVXA 1FUQA 4CEIA 4MX2A 1KQ7A 1GK3A 1U16A 2VD6A 4V2RA 3R6VA 3UNVA 4FBSA 1GKJA 1I50A 1Y2MA 1C3CA 5IZ2A 3NO9A 2A68D 2A6ED 3E04A 2NYNA 4BABA 1FUOA 1XMCA 3GZHA 5M0JA 2X0OA 4BAAA 1GKMA 4C5SA 1Q5NA 3R6QA 2FENA 2F5JA 2O78A 1B8FA 3RD8A 1XL8A 1K83A 2MQAA 1J3UA 3GTQA 1EZBA 2N3EA 1JSWA 1U15A 1TWAA 2K3NA 2LKMB 1R9TA 1TJWA 2JA6A 4EFCA 2PFMA 2Y0NA 2LPIA 4APAA 2QVEA 1AUWA 3GTMA 2N1DB 4FLCA 5HW2A 2JA7A 2VSFA 1XL7A 1ZYMA 2K3QA 3GTJA 2R92A 2HWGA 1YNND 2FIPA 1C3UA 1I3QA 3CQZA 5F92A 5H8WA 1EZAA 4QIWA 2RJRA 1RE5A 1DCNA 1I6VD 2J91A 3FKIA 1TJVA 2NYFA 4C5RA 2O7FA 1IW7D 2EZAA 3GTLA 2PTSA 2B63A 1EB4A 1FURA 1VDKA 2O7DA 4ADLA 2BE5D 2X75A 2E2IA 1TJ7A 1YFEA 2VL7A 3U4QA 3OCFA 2RJSA 1FUPA 2NVYA 1I0AA 2K3OA 3C8TA 1YNJD 2EZCA 3QBPA 2OHYA 1XMDA 1T6JA 5F91A 3NZ4A 4ADMA 4APBA 2VUMA 2MX9A 2LTHA 3EZEA 4HGVA 1K62A 2EZBA 1ZYRD 2LPJA 2O5JD 2FUSA 1W27A 4CEJA 2AQLA 1XWOA 1YFMA 5M0IA 1GK2A 2O7BA 3GTGA 5EYVA 1WCMA 2MP0A 3CRW1 2A6HD 3GTDA 1HY1A 1TWHA 2QGAB 3RRPA 4CEHA 2O6YA 3KDYA 2E9FA 3BHGA 3TV2A 2MX8A 1HY0A 4CQ5A 3CZOA 4NSLA 2X0QA 1YISA 1SFOA 4C2MA 1Y1VA
chains in the Genus database with same CATH topology
4EEIA 5EYTA 1K7WA 1DOFA 2HVGA 4FFXA 2YIIA 1TJUA 2PTQA 3OCEA 2PTRA 3R6YA 4C6GA 4C5UA 4NLEA 5D6BA 1T6PA 3KDZA 4V2QA 2O7EA 1FUQA 4MX2A 1KQ7A 1GK3A 1U16A 2VD6A 4V2RA 3R6VA 3UNVA 1GKJA 1Y2MA 1C3CA 3NO9A 3E04A 2NYNA 4BABA 1FUOA 3GZHA 4BAAA 1GKMA 4C5SA 1Q5NA 3R6QA 2O78A 1B8FA 3RD8A 1J3UA 1U15A 1JSWA 1TJWA 4EFCA 2PFMA 4APAA 2QVEA 1AUWA 4FLCA 5HW2A 1C3UA 5F92A 2RJRA 1RE5A 1DCNA 2J91A 2NYFA 4C5RA 2O7FA 2PTSA 1EB4A 1FURA 1VDKA 2O7DA 4ADLA 2X75A 1TJ7A 1YFEA 3OCFA 2RJSA 1FUPA 3C8TA 1I0AA 3QBPA 2OHYA 1T6JA 5F91A 3NZ4A 4ADMA 4APBA 4HGVA 1K62A 2FUSA 1W27A 1XWOA 1YFMA 1GK2A 2O7BA 5EYVA 3GTDA 1HY1A 2QGAB 3RRPA 2O6YA 3KDYA 3BHGA 2E9FA 3TV2A 1HY0A 4CQ5A 3CZOA 4NSLA 1YISA 1TJVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EEI A;  5EYT A;  1K7W A;  1DOF A;  2HVG A;  4FFX A;  2YII A;  1TJU A;  2PTQ A;  3OCE A;  2PTR A;  3R6Y A;  4C6G A;  4C5U A;  4NLE A;  5D6B A;  1T6P A;  3KDZ A;  4V2Q A;  2O7E A;  1FUQ A;  4MX2 A;  1KQ7 A;  1GK3 A;  1U16 A;  2VD6 A;  4V2R A;  3R6V A;  3UNV A;  1GKJ A;  1Y2M A;  1C3C A;  3NO9 A;  3E04 A;  2NYN A;  4BAB A;  1FUO A;  3GZH A;  4BAA A;  1GKM A;  4C5S A;  1Q5N A;  3R6Q A;  2O78 A;  1B8F A;  3RD8 A;  1J3U A;  1U15 A;  1JSW A;  1TJW A;  4EFC A;  2PFM A;  4APA A;  2QVE A;  1AUW A;  4FLC A;  5HW2 A;  1C3U A;  5F92 A;  2RJR A;  1RE5 A;  1DCN A;  2J91 A;  2NYF A;  4C5R A;  2O7F A;  2PTS A;  1EB4 A;  1FUR A;  1VDK A;  2O7D A;  4ADL A;  2X75 A;  1TJ7 A;  1YFE A;  3OCF A;  2RJS A;  1FUP A;  3C8T A;  1I0A A;  3QBP A;  2OHY A;  1T6J A;  5F91 A;  3NZ4 A;  4ADM A;  4APB A;  4HGV A;  1K62 A;  2FUS A;  1W27 A;  1XWO A;  1YFM A;  1GK2 A;  2O7B A;  5EYV A;  3GTD A;  1HY1 A;  2QGA B;  3RRP A;  2O6Y A;  3KDY A;  3BHG A;  2E9F A;  3TV2 A;  1HY0 A;  4CQ5 A;  3CZO A;  4NSL A;  1YIS A;  1TJV A; 
#chains in the Genus database with same CATH topology
 4EEI A;  3LR6 A;  5EYT A;  1K7W A;  1HQM D;  4A15 A;  3GTP A;  1DOF A;  3GTK A;  2HVG A;  2X0P A;  2YII A;  4FFX A;  4WNL A;  1TJU A;  2PTQ A;  1XLY A;  3LRD A;  2A69 D;  3LR2 A;  3CRV A;  3OCE A;  3EZB A;  2PTR A;  2R93 A;  4C6G A;  3R6Y A;  2FEL A;  4C5U A;  2HRO A;  3U44 A;  2CW0 D;  3GTO A;  1TWF A;  2E2H A;  2R7Z A;  2JA5 A;  1TWC A;  4NLE A;  3EZA A;  3LR8 A;  5D6B A;  3H0G A;  1Y1W A;  2LYI A;  1T6P A;  2VK9 A;  3KDZ A;  1TWG A;  2YU9 A;  4V2Q A;  1SMY D;  2O7E A;  2FIO A;  2NVX A;  1FUQ A;  4CEI A;  4MX2 A;  1KQ7 A;  1GK3 A;  1U16 A;  2VD6 A;  4V2R A;  3R6V A;  3UNV A;  4FBS A;  1GKJ A;  1I50 A;  1Y2M A;  1C3C A;  5IZ2 A;  3NO9 A;  2A68 D;  2A6E D;  3E04 A;  2NYN A;  4BAB A;  1FUO A;  1XMC A;  3GZH A;  5M0J A;  2X0O A;  4BAA A;  1GKM A;  4C5S A;  1Q5N A;  3R6Q A;  2FEN A;  2F5J A;  2O78 A;  1B8F A;  3RD8 A;  1XL8 A;  1K83 A;  2MQA A;  1J3U A;  3GTQ A;  1EZB A;  2N3E A;  1JSW A;  1U15 A;  1TWA A;  2K3N A;  2LKM B;  1R9T A;  1TJW A;  2JA6 A;  4EFC A;  2PFM A;  2Y0N A;  2LPI A;  4APA A;  2QVE A;  1AUW A;  3GTM A;  2N1D B;  4FLC A;  5HW2 A;  2JA7 A;  2VSF A;  1XL7 A;  1ZYM A;  2K3Q A;  3GTJ A;  2R92 A;  2HWG A;  1YNN D;  2FIP A;  1C3U A;  1I3Q A;  3CQZ A;  5F92 A;  5H8W A;  1EZA A;  4QIW A;  2RJR A;  1RE5 A;  1DCN A;  1I6V D;  2J91 A;  3FKI A;  1TJV A;  2NYF A;  4C5R A;  2O7F A;  1IW7 D;  2EZA A;  3GTL A;  2PTS A;  2B63 A;  1EB4 A;  1FUR A;  1VDK A;  2O7D A;  4ADL A;  2BE5 D;  2X75 A;  2E2I A;  1TJ7 A;  1YFE A;  2VL7 A;  3U4Q A;  3OCF A;  2RJS A;  1FUP A;  2NVY A;  1I0A A;  2K3O A;  3C8T A;  1YNJ D;  2EZC A;  3QBP A;  2OHY A;  1XMD A;  1T6J A;  5F91 A;  3NZ4 A;  4ADM A;  4APB A;  2VUM A;  2MX9 A;  2LTH A;  3EZE A;  4HGV A;  1K62 A;  2EZB A;  1ZYR D;  2LPJ A;  2O5J D;  2FUS A;  1W27 A;  4CEJ A;  2AQL A;  1XWO A;  1YFM A;  5M0I A;  1GK2 A;  2O7B A;  3GTG A;  5EYV A;  1WCM A;  2MP0 A;  3CRW 1;  2A6H D;  3GTD A;  1HY1 A;  1TWH A;  2QGA B;  3RRP A;  4CEH A;  2O6Y A;  3KDY A;  2E9F A;  3BHG A;  3TV2 A;  2MX8 A;  1HY0 A;  4CQ5 A;  3CZO A;  4NSL A;  2X0Q A;  1YIS A;  1SFO A;  4C2M A;  1Y1V A; 
#chains in the Genus database with same CATH homology
 4EEI A;  5EYT A;  1K7W A;  1DOF A;  2HVG A;  4FFX A;  2YII A;  1TJU A;  2PTQ A;  3OCE A;  2PTR A;  3R6Y A;  4C6G A;  4C5U A;  4NLE A;  5D6B A;  1T6P A;  3KDZ A;  4V2Q A;  2O7E A;  1FUQ A;  4MX2 A;  1KQ7 A;  1GK3 A;  1U16 A;  2VD6 A;  4V2R A;  3R6V A;  3UNV A;  1GKJ A;  1Y2M A;  1C3C A;  3NO9 A;  3E04 A;  2NYN A;  4BAB A;  1FUO A;  3GZH A;  4BAA A;  1GKM A;  4C5S A;  1Q5N A;  3R6Q A;  2O78 A;  1B8F A;  3RD8 A;  1J3U A;  1U15 A;  1JSW A;  1TJW A;  4EFC A;  2PFM A;  4APA A;  2QVE A;  1AUW A;  4FLC A;  5HW2 A;  1C3U A;  5F92 A;  2RJR A;  1RE5 A;  1DCN A;  2J91 A;  2NYF A;  4C5R A;  2O7F A;  2PTS A;  1EB4 A;  1FUR A;  1VDK A;  2O7D A;  4ADL A;  2X75 A;  1TJ7 A;  1YFE A;  3OCF A;  2RJS A;  1FUP A;  3C8T A;  1I0A A;  3QBP A;  2OHY A;  1T6J A;  5F91 A;  3NZ4 A;  4ADM A;  4APB A;  4HGV A;  1K62 A;  2FUS A;  1W27 A;  1XWO A;  1YFM A;  1GK2 A;  2O7B A;  5EYV A;  3GTD A;  1HY1 A;  2QGA B;  3RRP A;  2O6Y A;  3KDY A;  3BHG A;  2E9F A;  3TV2 A;  1HY0 A;  4CQ5 A;  3CZO A;  4NSL A;  1YIS A;  1TJV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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