2YIIA

Manipulating the regioselectivity of phenylalanine aminomutase: new insights into the reaction mechanism of mio-dependent enzymes from structure-guided directed evolution
Total Genus 260
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
260
sequence length
667
structure length
643
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTKVDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHKDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE
publication title Mechanism-Inspired Engineering of Phenylalanine Aminomutase for Enhanced Beta-Regioselective Asymmetric Amination of Cinnamates.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
total genus 260
structure length 643
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2011-05-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 2yiiA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2yiiA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2yiiA02
1FUPA 2O78A 1RE5A 1U15A 4NSLA 4ADMA 3RD8A 1HY0A 4EFCA 5EYVA 4C5UA 1C3UA 2PTQA 1FUOA 3C8TA 1FURA 2O6YA 2RJRA 4APBA 3R6VA 2OHYA 4C6GA 1JSWA 1FUQA 4V2RA 1Q5NA 1B8FA 4BABA 1Y2MA 4NLEA 2YIIA 2O7DA 3NO9A 4APAA 1KQ7A 1DOFA 1YFEA 2NYFA 1HY1A 4FLCA 1TJ7A 3R6YA 3UNVA 5EYTA 1GKJA 1TJVA 4V2QA 1C3CA 2PTRA 1EB4A 2PFMA 1GKMA 4C5SA 2FUSA 1W27A 1K7WA 2X75A 3GTDA 4ADLA 1T6JA 3E04A 2QVEA 3KDZA 3RRPA 4CQ5A 2O7FA 1TJUA 5F92A 4FFXA 2O7BA 3KDYA 3CZOA 1I0AA 3OCEA 3TV2A 4EEIA 1K62A 2QGAB 5F91A 1TJWA 3BHGA 2HVGA 2E9FA 1U16A 1AUWA 1T6PA 1J3UA 3R6QA 4C5RA 5D6BA 2PTSA 2RJSA 1GK2A 2NYNA 5HW2A 1YISA 3QBPA 1XWOA 3NZ4A 1YFMA 2VD6A 3GZHA 1VDKA 4BAAA 3OCFA 4HGVA 2J91A 1DCNA 1GK3A 2O7EA 4MX2A
chains in the Genus database with same CATH superfamily
2A6ED 1FUPA 3GTOA 2O78A 3OCEA 1IW7D 2O5JD 1RE5A 1U15A 4NSLA 4CEJA 4ADMA 2N1DB 3RD8A 1HY0A 3EZBA 4EFCA 2K3NA 1ZYRD 2VK9A 5EYVA 4C5UA 1C3UA 2PTQA 1FUOA 2X0PA 2E2HA 3C8TA 4WNLA 3U4QA 2YU9A 3GTPA 1FURA 1TWFA 1ZYMA 2NVYA 1I3QA 1TWHA 2O6YA 2K3OA 2RJRA 4APBA 2X0QA 5H8WA 1Y1VA 2BE5D 3R6VA 2OHYA 4C6GA 1Y1WA 1JSWA 1FUQA 3LRDA 2JA7A 4V2RA 2JA6A 4C2MA 2HROA 3U44A 2Y0NA 1Q5NA 1B8FA 2F5JA 4A15A 2EZCA 2LPIA 4BABA 1XL8A 2VSFA 2NVXA 1Y2MA 2MQAA 4NLEA 1HQMD 2YIIA 1YNND 1YNJD 3GTJA 2O7DA 3NO9A 2FENA 1EZAA 1TWGA 2HWGA 3H0GA 5IZ2A 4APAA 1KQ7A 1DOFA 1YFEA 2NYFA 1HY1A 4FLCA 1TJ7A 1XMDA 3R6YA 3UNVA 5EYTA 1K83A 1GKJA 1TJVA 4V2QA 1C3CA 2PTRA 1EB4A 2AQLA 1GKMA 4C5SA 2JA5A 2PFMA 1I6VD 2E2IA 2FUSA 2VL7A 4CEHA 1XL7A 3GTLA 1W27A 2B63A 1K7WA 3GTKA 2FIOA 2LKMB 2X75A 3GTMA 1EZBA 2A68D 3CRW1 3GTDA 2MX8A 4ADLA 1T6JA 3LR8A 1R9TA 3E04A 4EEIA 1I50A 2QVEA 2A6HD 2A69D 4QIWA 1TWCA 2X0OA 3KDZA 3RRPA 4FBSA 4CQ5A 2O7FA 5M0JA 1SMYD 1TJUA 2FIPA 2VUMA 3CQZA 5F92A 4FFXA 2O7BA 3KDYA 1TWAA 2CW0D 3LR2A 1I0AA 3CZOA 2MP0A 1WCMA 3LR6A 1K62A 2QGAB 3TV2A 4CEIA 5M0IA 3EZAA 5F91A 1XLYA 3FKIA 1TJWA 2EZBA 3BHGA 2HVGA 2R92A 2E9FA 1SFOA 2EZAA 1U16A 1AUWA 1T6PA 1J3UA 3R6QA 4C5RA 2LTHA 5D6BA 2K3QA 2PTSA 2RJSA 1GK2A 3GTGA 2NYNA 5HW2A 2LPJA 2R93A 1XMCA 3CRVA 1YISA 3QBPA 3EZEA 3NZ4A 2LYIA 2MX9A 1XWOA 1YFMA 1VDKA 2VD6A 4BAAA 3GZHA 2FELA 3OCFA 2R7ZA 4HGVA 2J91A 1DCNA 1GK3A 2O7EA 4MX2A 2N3EA 3GTQA
chains in the Genus database with same CATH topology
1FUPA 2O78A 1RE5A 1U15A 4NSLA 4ADMA 3RD8A 1HY0A 4EFCA 5EYVA 4C5UA 1C3UA 2PTQA 1FUOA 3C8TA 1FURA 2O6YA 2RJRA 4APBA 3R6VA 2OHYA 4C6GA 1JSWA 1FUQA 4V2RA 1Q5NA 1B8FA 4BABA 1Y2MA 4NLEA 2YIIA 2O7DA 3NO9A 4APAA 1KQ7A 1DOFA 1YFEA 2NYFA 1HY1A 4FLCA 1TJ7A 3R6YA 3UNVA 5EYTA 1GKJA 1TJVA 4V2QA 1C3CA 2PTRA 1EB4A 2PFMA 1GKMA 4C5SA 2FUSA 1W27A 1K7WA 2X75A 3GTDA 4ADLA 1T6JA 3E04A 2QVEA 3KDZA 3RRPA 4CQ5A 2O7FA 1TJUA 5F92A 4FFXA 2O7BA 3KDYA 3CZOA 1I0AA 3OCEA 3TV2A 4EEIA 1K62A 2QGAB 5F91A 1TJWA 3BHGA 2HVGA 2E9FA 1U16A 1AUWA 1T6PA 1J3UA 3R6QA 4C5RA 5D6BA 2PTSA 2RJSA 1GK2A 2NYNA 5HW2A 1YISA 3QBPA 1XWOA 3NZ4A 1YFMA 2VD6A 3GZHA 1VDKA 4BAAA 3OCFA 4HGVA 2J91A 1DCNA 1GK3A 2O7EA 4MX2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FUP A;  2O78 A;  1RE5 A;  1U15 A;  4NSL A;  4ADM A;  3RD8 A;  1HY0 A;  4EFC A;  5EYV A;  4C5U A;  1C3U A;  2PTQ A;  1FUO A;  3C8T A;  1FUR A;  2O6Y A;  2RJR A;  4APB A;  3R6V A;  2OHY A;  4C6G A;  1JSW A;  1FUQ A;  4V2R A;  1Q5N A;  1B8F A;  4BAB A;  1Y2M A;  4NLE A;  2YII A;  2O7D A;  3NO9 A;  4APA A;  1KQ7 A;  1DOF A;  1YFE A;  2NYF A;  1HY1 A;  4FLC A;  1TJ7 A;  3R6Y A;  3UNV A;  5EYT A;  1GKJ A;  1TJV A;  4V2Q A;  1C3C A;  2PTR A;  1EB4 A;  2PFM A;  1GKM A;  4C5S A;  2FUS A;  1W27 A;  1K7W A;  2X75 A;  3GTD A;  4ADL A;  1T6J A;  3E04 A;  2QVE A;  3KDZ A;  3RRP A;  4CQ5 A;  2O7F A;  1TJU A;  5F92 A;  4FFX A;  2O7B A;  3KDY A;  3CZO A;  1I0A A;  3OCE A;  3TV2 A;  4EEI A;  1K62 A;  2QGA B;  5F91 A;  1TJW A;  3BHG A;  2HVG A;  2E9F A;  1U16 A;  1AUW A;  1T6P A;  1J3U A;  3R6Q A;  4C5R A;  5D6B A;  2PTS A;  2RJS A;  1GK2 A;  2NYN A;  5HW2 A;  1YIS A;  3QBP A;  1XWO A;  3NZ4 A;  1YFM A;  2VD6 A;  3GZH A;  1VDK A;  4BAA A;  3OCF A;  4HGV A;  2J91 A;  1DCN A;  1GK3 A;  2O7E A;  4MX2 A; 
#chains in the Genus database with same CATH topology
 2A6E D;  1FUP A;  3GTO A;  2O78 A;  3OCE A;  1IW7 D;  2O5J D;  1RE5 A;  1U15 A;  4NSL A;  4CEJ A;  4ADM A;  2N1D B;  3RD8 A;  1HY0 A;  3EZB A;  4EFC A;  2K3N A;  1ZYR D;  2VK9 A;  5EYV A;  4C5U A;  1C3U A;  2PTQ A;  1FUO A;  2X0P A;  2E2H A;  3C8T A;  4WNL A;  3U4Q A;  2YU9 A;  3GTP A;  1FUR A;  1TWF A;  1ZYM A;  2NVY A;  1I3Q A;  1TWH A;  2O6Y A;  2K3O A;  2RJR A;  4APB A;  2X0Q A;  5H8W A;  1Y1V A;  2BE5 D;  3R6V A;  2OHY A;  4C6G A;  1Y1W A;  1JSW A;  1FUQ A;  3LRD A;  2JA7 A;  4V2R A;  2JA6 A;  4C2M A;  2HRO A;  3U44 A;  2Y0N A;  1Q5N A;  1B8F A;  2F5J A;  4A15 A;  2EZC A;  2LPI A;  4BAB A;  1XL8 A;  2VSF A;  2NVX A;  1Y2M A;  2MQA A;  4NLE A;  1HQM D;  2YII A;  1YNN D;  1YNJ D;  3GTJ A;  2O7D A;  3NO9 A;  2FEN A;  1EZA A;  1TWG A;  2HWG A;  3H0G A;  5IZ2 A;  4APA A;  1KQ7 A;  1DOF A;  1YFE A;  2NYF A;  1HY1 A;  4FLC A;  1TJ7 A;  1XMD A;  3R6Y A;  3UNV A;  5EYT A;  1K83 A;  1GKJ A;  1TJV A;  4V2Q A;  1C3C A;  2PTR A;  1EB4 A;  2AQL A;  1GKM A;  4C5S A;  2JA5 A;  2PFM A;  1I6V D;  2E2I A;  2FUS A;  2VL7 A;  4CEH A;  1XL7 A;  3GTL A;  1W27 A;  2B63 A;  1K7W A;  3GTK A;  2FIO A;  2LKM B;  2X75 A;  3GTM A;  1EZB A;  2A68 D;  3CRW 1;  3GTD A;  2MX8 A;  4ADL A;  1T6J A;  3LR8 A;  1R9T A;  3E04 A;  4EEI A;  1I50 A;  2QVE A;  2A6H D;  2A69 D;  4QIW A;  1TWC A;  2X0O A;  3KDZ A;  3RRP A;  4FBS A;  4CQ5 A;  2O7F A;  5M0J A;  1SMY D;  1TJU A;  2FIP A;  2VUM A;  3CQZ A;  5F92 A;  4FFX A;  2O7B A;  3KDY A;  1TWA A;  2CW0 D;  3LR2 A;  1I0A A;  3CZO A;  2MP0 A;  1WCM A;  3LR6 A;  1K62 A;  2QGA B;  3TV2 A;  4CEI A;  5M0I A;  3EZA A;  5F91 A;  1XLY A;  3FKI A;  1TJW A;  2EZB A;  3BHG A;  2HVG A;  2R92 A;  2E9F A;  1SFO A;  2EZA A;  1U16 A;  1AUW A;  1T6P A;  1J3U A;  3R6Q A;  4C5R A;  2LTH A;  5D6B A;  2K3Q A;  2PTS A;  2RJS A;  1GK2 A;  3GTG A;  2NYN A;  5HW2 A;  2LPJ A;  2R93 A;  1XMC A;  3CRV A;  1YIS A;  3QBP A;  3EZE A;  3NZ4 A;  2LYI A;  2MX9 A;  1XWO A;  1YFM A;  1VDK A;  2VD6 A;  4BAA A;  3GZH A;  2FEL A;  3OCF A;  2R7Z A;  4HGV A;  2J91 A;  1DCN A;  1GK3 A;  2O7E A;  4MX2 A;  2N3E A;  3GTQ A; 
#chains in the Genus database with same CATH homology
 1FUP A;  2O78 A;  1RE5 A;  1U15 A;  4NSL A;  4ADM A;  3RD8 A;  1HY0 A;  4EFC A;  5EYV A;  4C5U A;  1C3U A;  2PTQ A;  1FUO A;  3C8T A;  1FUR A;  2O6Y A;  2RJR A;  4APB A;  3R6V A;  2OHY A;  4C6G A;  1JSW A;  1FUQ A;  4V2R A;  1Q5N A;  1B8F A;  4BAB A;  1Y2M A;  4NLE A;  2YII A;  2O7D A;  3NO9 A;  4APA A;  1KQ7 A;  1DOF A;  1YFE A;  2NYF A;  1HY1 A;  4FLC A;  1TJ7 A;  3R6Y A;  3UNV A;  5EYT A;  1GKJ A;  1TJV A;  4V2Q A;  1C3C A;  2PTR A;  1EB4 A;  2PFM A;  1GKM A;  4C5S A;  2FUS A;  1W27 A;  1K7W A;  2X75 A;  3GTD A;  4ADL A;  1T6J A;  3E04 A;  2QVE A;  3KDZ A;  3RRP A;  4CQ5 A;  2O7F A;  1TJU A;  5F92 A;  4FFX A;  2O7B A;  3KDY A;  3CZO A;  1I0A A;  3OCE A;  3TV2 A;  4EEI A;  1K62 A;  2QGA B;  5F91 A;  1TJW A;  3BHG A;  2HVG A;  2E9F A;  1U16 A;  1AUW A;  1T6P A;  1J3U A;  3R6Q A;  4C5R A;  5D6B A;  2PTS A;  2RJS A;  1GK2 A;  2NYN A;  5HW2 A;  1YIS A;  3QBP A;  1XWO A;  3NZ4 A;  1YFM A;  2VD6 A;  3GZH A;  1VDK A;  4BAA A;  3OCF A;  4HGV A;  2J91 A;  1DCN A;  1GK3 A;  2O7E A;  4MX2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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