2YIIA

Manipulating the regioselectivity of phenylalanine aminomutase: new insights into the reaction mechanism of mio-dependent enzymes from structure-guided directed evolution
Total Genus 260
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
260
sequence length
667
structure length
643
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTKVDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHKDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMMONIA-LYASE
publication title Mechanism-Inspired Engineering of Phenylalanine Aminomutase for Enhanced Beta-Regioselective Asymmetric Amination of Cinnamates.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 260
structure length 643
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2011-05-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 2yiiA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2yiiA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2yiiA02
1U15A 3C8TA 1C3UA 3NZ4A 2O7BA 1YFMA 1U16A 4NLEA 5EYVA 3R6QA 1TJUA 2FUSA 4EFCA 3OCFA 1T6PA 1B8FA 1FUQA 1FUOA 3GTDA 4ADMA 1T6JA 2QGAB 1DOFA 1EB4A 2O7DA 3OCEA 2NYNA 2E9FA 4FLCA 1GKMA 1YFEA 3CZOA 2PTQA 5EYTA 4BABA 3KDZA 4MX2A 3E04A 3NO9A 3GZHA 1I0AA 2PTSA 4C5UA 1RE5A 4V2QA 4BAAA 4C5RA 4C5SA 5D6BA 3UNVA 1TJWA 4APBA 2O7FA 2VD6A 2HVGA 5F91A 2RJRA 1DCNA 3RD8A 1AUWA 3R6YA 5HW2A 1GKJA 1J3UA 4CQ5A 2RJSA 3R6VA 3RRPA 1XWOA 4EEIA 1JSWA 4C6GA 1TJVA 3QBPA 3TV2A 2J91A 4ADLA 2X75A 1GK2A 2PFMA 2NYFA 4NSLA 1KQ7A 1YISA 2O78A 1Q5NA 4V2RA 2QVEA 1HY1A 3KDYA 5F92A 1C3CA 1W27A 2PTRA 3BHGA 4APAA 1FUPA 1Y2MA 1K7WA 2O7EA 1K62A 2YIIA 1FURA 1HY0A 2OHYA 4HGVA 1TJ7A 2O6YA 1VDKA 1GK3A 4FFXA
chains in the Genus database with same CATH superfamily
1U15A 3C8TA 1C3UA 1XMCA 3NZ4A 2LPIA 2O7BA 1YFMA 5M0IA 1U16A 4NLEA 2X0PA 1XL8A 5EYVA 3R6QA 1TJUA 2E2HA 2FUSA 4EFCA 3OCFA 1T6PA 1B8FA 1Y1WA 3CRVA 1FUQA 2N1DB 2AQLA 1FUOA 2LYIA 2F5JA 3EZEA 3GTDA 4ADMA 2YU9A 1T6JA 1TWAA 2QGAB 3GTQA 1DOFA 1EB4A 2O7DA 3OCEA 2NYNA 3GTMA 2E9FA 4FLCA 3U44A 2FIPA 2FIOA 1GKMA 1YFEA 3CZOA 2PTQA 5EYTA 4BABA 4CEIA 3KDZA 4MX2A 1YNND 3E04A 1R9TA 1EZBA 3EZBA 3NO9A 3GTJA 3GZHA 1I0AA 4A15A 2MP0A 3GTLA 2PTSA 4C5UA 2VSFA 1RE5A 4V2QA 4BAAA 2VL7A 2E2IA 3CQZA 1TWFA 4C5RA 2LKMB 3GTPA 4C5SA 5D6BA 2FELA 2NVXA 3UNVA 2R7ZA 1TJWA 4APBA 4CEHA 3GTKA 2O7FA 2EZCA 2VD6A 2HVGA 1XLYA 5F91A 1ZYMA 2RJRA 1DCNA 3H0GA 3EZAA 3RD8A 1I3QA 1AUWA 3R6YA 2R92A 5H8WA 5HW2A 1GKJA 3CRW1 1J3UA 2FENA 1WCMA 3LR6A 2VK9A 5IZ2A 1TWHA 4CQ5A 2RJSA 3R6VA 3RRPA 2LTHA 1SMYD 3LR8A 1XWOA 4EEIA 2A68D 2A6HD 2JA6A 1JSWA 4C6GA 2Y0NA 3LRDA 1I50A 1TJVA 1XMDA 3QBPA 3FKIA 3TV2A 2MQAA 2K3OA 2J91A 2K3QA 4ADLA 2X75A 1YNJD 2EZBA 1I6VD 3U4QA 4C2MA 1SFOA 1GK2A 2MX9A 2NYFA 1EZAA 2PFMA 4NSLA 5M0JA 2O5JD 1KQ7A 1YISA 3GTGA 2B63A 1Q5NA 2O78A 4V2RA 2QVEA 1HY1A 3KDYA 4CEJA 3GTOA 2BE5D 1TWGA 2R93A 2HWGA 1K83A 1XL7A 5F92A 1C3CA 2LPJA 2NVYA 1W27A 2X0QA 2PTRA 1IW7D 3BHGA 4APAA 1HQMD 1FUPA 4FBSA 2JA5A 3LR2A 2VUMA 4WNLA 2JA7A 1TWCA 1Y2MA 2A6ED 2X0OA 2N3EA 1K7WA 2A69D 2O7EA 2MX8A 1K62A 2YIIA 1FURA 1Y1VA 2CW0D 2K3NA 1HY0A 2OHYA 4HGVA 1TJ7A 2HROA 2O6YA 2EZAA 1VDKA 1GK3A 4FFXA 1ZYRD 4QIWA
chains in the Genus database with same CATH topology
1U15A 3C8TA 1C3UA 3NZ4A 2O7BA 1YFMA 1U16A 4NLEA 5EYVA 3R6QA 1TJUA 2FUSA 4EFCA 3OCFA 1T6PA 1B8FA 1FUQA 1FUOA 3GTDA 4ADMA 1T6JA 2QGAB 1DOFA 1EB4A 2O7DA 3OCEA 2NYNA 2E9FA 4FLCA 1GKMA 1YFEA 3CZOA 2PTQA 5EYTA 4BABA 3KDZA 4MX2A 3E04A 3NO9A 3GZHA 1I0AA 2PTSA 4C5UA 1RE5A 4V2QA 4BAAA 4C5RA 4C5SA 5D6BA 3UNVA 1TJWA 4APBA 2O7FA 2VD6A 2HVGA 5F91A 2RJRA 1DCNA 3RD8A 1AUWA 3R6YA 5HW2A 1GKJA 1J3UA 4CQ5A 2RJSA 3R6VA 3RRPA 1XWOA 4EEIA 1JSWA 4C6GA 1TJVA 3QBPA 3TV2A 2J91A 4ADLA 2X75A 1GK2A 2PFMA 2NYFA 4NSLA 1KQ7A 1YISA 2O78A 1Q5NA 4V2RA 2QVEA 1HY1A 3KDYA 5F92A 1C3CA 1W27A 2PTRA 3BHGA 4APAA 1FUPA 1Y2MA 1K7WA 2O7EA 1K62A 2YIIA 1FURA 1HY0A 2OHYA 4HGVA 1TJ7A 2O6YA 1VDKA 1GK3A 4FFXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1U15 A;  3C8T A;  1C3U A;  3NZ4 A;  2O7B A;  1YFM A;  1U16 A;  4NLE A;  5EYV A;  3R6Q A;  1TJU A;  2FUS A;  4EFC A;  3OCF A;  1T6P A;  1B8F A;  1FUQ A;  1FUO A;  3GTD A;  4ADM A;  1T6J A;  2QGA B;  1DOF A;  1EB4 A;  2O7D A;  3OCE A;  2NYN A;  2E9F A;  4FLC A;  1GKM A;  1YFE A;  3CZO A;  2PTQ A;  5EYT A;  4BAB A;  3KDZ A;  4MX2 A;  3E04 A;  3NO9 A;  3GZH A;  1I0A A;  2PTS A;  4C5U A;  1RE5 A;  4V2Q A;  4BAA A;  4C5R A;  4C5S A;  5D6B A;  3UNV A;  1TJW A;  4APB A;  2O7F A;  2VD6 A;  2HVG A;  5F91 A;  2RJR A;  1DCN A;  3RD8 A;  1AUW A;  3R6Y A;  5HW2 A;  1GKJ A;  1J3U A;  4CQ5 A;  2RJS A;  3R6V A;  3RRP A;  1XWO A;  4EEI A;  1JSW A;  4C6G A;  1TJV A;  3QBP A;  3TV2 A;  2J91 A;  4ADL A;  2X75 A;  1GK2 A;  2PFM A;  2NYF A;  4NSL A;  1KQ7 A;  1YIS A;  2O78 A;  1Q5N A;  4V2R A;  2QVE A;  1HY1 A;  3KDY A;  5F92 A;  1C3C A;  1W27 A;  2PTR A;  3BHG A;  4APA A;  1FUP A;  1Y2M A;  1K7W A;  2O7E A;  1K62 A;  2YII A;  1FUR A;  1HY0 A;  2OHY A;  4HGV A;  1TJ7 A;  2O6Y A;  1VDK A;  1GK3 A;  4FFX A; 
#chains in the Genus database with same CATH topology
 1U15 A;  3C8T A;  1C3U A;  1XMC A;  3NZ4 A;  2LPI A;  2O7B A;  1YFM A;  5M0I A;  1U16 A;  4NLE A;  2X0P A;  1XL8 A;  5EYV A;  3R6Q A;  1TJU A;  2E2H A;  2FUS A;  4EFC A;  3OCF A;  1T6P A;  1B8F A;  1Y1W A;  3CRV A;  1FUQ A;  2N1D B;  2AQL A;  1FUO A;  2LYI A;  2F5J A;  3EZE A;  3GTD A;  4ADM A;  2YU9 A;  1T6J A;  1TWA A;  2QGA B;  3GTQ A;  1DOF A;  1EB4 A;  2O7D A;  3OCE A;  2NYN A;  3GTM A;  2E9F A;  4FLC A;  3U44 A;  2FIP A;  2FIO A;  1GKM A;  1YFE A;  3CZO A;  2PTQ A;  5EYT A;  4BAB A;  4CEI A;  3KDZ A;  4MX2 A;  1YNN D;  3E04 A;  1R9T A;  1EZB A;  3EZB A;  3NO9 A;  3GTJ A;  3GZH A;  1I0A A;  4A15 A;  2MP0 A;  3GTL A;  2PTS A;  4C5U A;  2VSF A;  1RE5 A;  4V2Q A;  4BAA A;  2VL7 A;  2E2I A;  3CQZ A;  1TWF A;  4C5R A;  2LKM B;  3GTP A;  4C5S A;  5D6B A;  2FEL A;  2NVX A;  3UNV A;  2R7Z A;  1TJW A;  4APB A;  4CEH A;  3GTK A;  2O7F A;  2EZC A;  2VD6 A;  2HVG A;  1XLY A;  5F91 A;  1ZYM A;  2RJR A;  1DCN A;  3H0G A;  3EZA A;  3RD8 A;  1I3Q A;  1AUW A;  3R6Y A;  2R92 A;  5H8W A;  5HW2 A;  1GKJ A;  3CRW 1;  1J3U A;  2FEN A;  1WCM A;  3LR6 A;  2VK9 A;  5IZ2 A;  1TWH A;  4CQ5 A;  2RJS A;  3R6V A;  3RRP A;  2LTH A;  1SMY D;  3LR8 A;  1XWO A;  4EEI A;  2A68 D;  2A6H D;  2JA6 A;  1JSW A;  4C6G A;  2Y0N A;  3LRD A;  1I50 A;  1TJV A;  1XMD A;  3QBP A;  3FKI A;  3TV2 A;  2MQA A;  2K3O A;  2J91 A;  2K3Q A;  4ADL A;  2X75 A;  1YNJ D;  2EZB A;  1I6V D;  3U4Q A;  4C2M A;  1SFO A;  1GK2 A;  2MX9 A;  2NYF A;  1EZA A;  2PFM A;  4NSL A;  5M0J A;  2O5J D;  1KQ7 A;  1YIS A;  3GTG A;  2B63 A;  1Q5N A;  2O78 A;  4V2R A;  2QVE A;  1HY1 A;  3KDY A;  4CEJ A;  3GTO A;  2BE5 D;  1TWG A;  2R93 A;  2HWG A;  1K83 A;  1XL7 A;  5F92 A;  1C3C A;  2LPJ A;  2NVY A;  1W27 A;  2X0Q A;  2PTR A;  1IW7 D;  3BHG A;  4APA A;  1HQM D;  1FUP A;  4FBS A;  2JA5 A;  3LR2 A;  2VUM A;  4WNL A;  2JA7 A;  1TWC A;  1Y2M A;  2A6E D;  2X0O A;  2N3E A;  1K7W A;  2A69 D;  2O7E A;  2MX8 A;  1K62 A;  2YII A;  1FUR A;  1Y1V A;  2CW0 D;  2K3N A;  1HY0 A;  2OHY A;  4HGV A;  1TJ7 A;  2HRO A;  2O6Y A;  2EZA A;  1VDK A;  1GK3 A;  4FFX A;  1ZYR D;  4QIW A; 
#chains in the Genus database with same CATH homology
 1U15 A;  3C8T A;  1C3U A;  3NZ4 A;  2O7B A;  1YFM A;  1U16 A;  4NLE A;  5EYV A;  3R6Q A;  1TJU A;  2FUS A;  4EFC A;  3OCF A;  1T6P A;  1B8F A;  1FUQ A;  1FUO A;  3GTD A;  4ADM A;  1T6J A;  2QGA B;  1DOF A;  1EB4 A;  2O7D A;  3OCE A;  2NYN A;  2E9F A;  4FLC A;  1GKM A;  1YFE A;  3CZO A;  2PTQ A;  5EYT A;  4BAB A;  3KDZ A;  4MX2 A;  3E04 A;  3NO9 A;  3GZH A;  1I0A A;  2PTS A;  4C5U A;  1RE5 A;  4V2Q A;  4BAA A;  4C5R A;  4C5S A;  5D6B A;  3UNV A;  1TJW A;  4APB A;  2O7F A;  2VD6 A;  2HVG A;  5F91 A;  2RJR A;  1DCN A;  3RD8 A;  1AUW A;  3R6Y A;  5HW2 A;  1GKJ A;  1J3U A;  4CQ5 A;  2RJS A;  3R6V A;  3RRP A;  1XWO A;  4EEI A;  1JSW A;  4C6G A;  1TJV A;  3QBP A;  3TV2 A;  2J91 A;  4ADL A;  2X75 A;  1GK2 A;  2PFM A;  2NYF A;  4NSL A;  1KQ7 A;  1YIS A;  2O78 A;  1Q5N A;  4V2R A;  2QVE A;  1HY1 A;  3KDY A;  5F92 A;  1C3C A;  1W27 A;  2PTR A;  3BHG A;  4APA A;  1FUP A;  1Y2M A;  1K7W A;  2O7E A;  1K62 A;  2YII A;  1FUR A;  1HY0 A;  2OHY A;  4HGV A;  1TJ7 A;  2O6Y A;  1VDK A;  1GK3 A;  4FFX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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