2YIIA

Manipulating the regioselectivity of phenylalanine aminomutase: new insights into the reaction mechanism of mio-dependent enzymes from structure-guided directed evolution
Total Genus 260
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
260
sequence length
667
structure length
643
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTKVDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHKDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Mechanism-Inspired Engineering of Phenylalanine Aminomutase for Enhanced Beta-Regioselective Asymmetric Amination of Cinnamates.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE
total genus 260
structure length 643
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2011-05-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 2yiiA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2yiiA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2yiiA02
1GK3A 1Q5NA 3NZ4A 3KDZA 3OCEA 2O7FA 1B8FA 2QVEA 3RRPA 5F91A 1YISA 5EYVA 2O6YA 2QGAB 1K62A 2FUSA 3KDYA 4C6GA 1J3UA 1FUOA 1TJ7A 4ADLA 4NSLA 2PTSA 2RJSA 2O7EA 4HGVA 2RJRA 2VD6A 4V2RA 1T6PA 5D6BA 2O7DA 3TV2A 1I0AA 4C5RA 2OHYA 2E9FA 3R6VA 1GKMA 3GZHA 1TJWA 4APBA 4FLCA 5HW2A 1JSWA 1HY1A 2PTRA 1TJVA 1XWOA 1U16A 4FFXA 4CQ5A 5F92A 4BAAA 1C3UA 2PFMA 2X75A 1DCNA 1T6JA 1HY0A 4C5SA 1C3CA 1W27A 3RD8A 1FUQA 1Y2MA 2YIIA 1YFEA 1K7WA 4NLEA 1FUPA 4APAA 3C8TA 3QBPA 3UNVA 1AUWA 3CZOA 2NYFA 1GKJA 1DOFA 4EFCA 4C5UA 2NYNA 3GTDA 3E04A 4EEIA 1EB4A 3BHGA 1FURA 3NO9A 3R6YA 2O7BA 5EYTA 2J91A 4MX2A 2O78A 1KQ7A 2HVGA 4V2QA 1U15A 3OCFA 3R6QA 1TJUA 1RE5A 4ADMA 1VDKA 4BABA 1YFMA 2PTQA 1GK2A
chains in the Genus database with same CATH superfamily
2VUMA 1GK3A 1Q5NA 2N1DB 3NZ4A 1Y1VA 1SMYD 3EZEA 3CQZA 3EZBA 1I50A 1ZYRD 1WCMA 3KDZA 3OCEA 3GTKA 2LYIA 2O7FA 1B8FA 1HQMD 2EZBA 4CEHA 3GTJA 2QVEA 1I3QA 1YISA 5EYVA 5F91A 3RRPA 1XMCA 2O6YA 2F5JA 2QGAB 3LRDA 2B63A 4CEIA 1K62A 2VL7A 2FUSA 3KDYA 2VSFA 1GK2A 2EZAA 4C6GA 2K3OA 1J3UA 4QIWA 1FUOA 2MQAA 2EZCA 1TJ7A 4ADLA 4NSLA 2PTSA 2RJSA 2O7EA 4HGVA 2A6ED 4FBSA 3LR8A 2N3EA 5M0JA 2X0PA 2RJRA 2VD6A 3GTMA 4V2RA 2FENA 1T6PA 5D6BA 2O7DA 3TV2A 3GTLA 1I0AA 4C5RA 5IZ2A 4CEJA 2OHYA 2E9FA 3R6VA 1GKMA 2A69D 2K3QA 3GZHA 1TJWA 2MX8A 4APBA 3LR2A 2R7ZA 1IW7D 2CW0D 4FLCA 5HW2A 1JSWA 2JA5A 3LR6A 2MP0A 1HY1A 2PTRA 1TWFA 1R9TA 1TWAA 1TJVA 1XWOA 2LKMB 2R92A 1U16A 3GTOA 1TWGA 2LPJA 4FFXA 4CQ5A 2E2HA 1I6VD 3GTPA 2FELA 1YNJD 4C2MA 5M0IA 5F92A 4BAAA 2JA7A 1K83A 1XMDA 1C3UA 2NVXA 3GTGA 2K3NA 2PFMA 2X75A 1DCNA 1TWHA 1T6JA 2LTHA 1HY0A 4C5SA 4WNLA 2A6HD 3GTQA 5H8WA 1W27A 1C3CA 2A68D 2X0OA 1FUQA 1Y2MA 2HWGA 1ZYMA 3EZAA 3RD8A 2YIIA 1YFEA 2R93A 2BE5D 1K7WA 4NLEA 2YU9A 3FKIA 1FUPA 4APAA 3C8TA 3QBPA 1XL8A 2X0QA 3UNVA 3U4QA 1EZAA 3U44A 1Y1WA 1AUWA 3CZOA 2NYFA 1GKJA 1DOFA 4EFCA 2O5JD 2NVYA 3CRVA 4C5UA 1SFOA 2NYNA 3GTDA 3E04A 4EEIA 2VK9A 1EB4A 3H0GA 1FURA 3BHGA 3NO9A 3R6YA 2O7BA 5EYTA 2HROA 2J91A 4MX2A 2FIOA 2Y0NA 1XL7A 2MX9A 2O78A 1KQ7A 2HVGA 4A15A 2LPIA 4V2QA 1U15A 3CRW1 1XLYA 3OCFA 2JA6A 3R6QA 1TJUA 1RE5A 2FIPA 4ADMA 1VDKA 4BABA 1EZBA 1YFMA 2PTQA 1YNND 1TWCA 2E2IA 2AQLA
chains in the Genus database with same CATH topology
1GK3A 1Q5NA 3NZ4A 3KDZA 3OCEA 2O7FA 1B8FA 2QVEA 3RRPA 5F91A 1YISA 5EYVA 2O6YA 2QGAB 1K62A 2FUSA 3KDYA 4C6GA 1J3UA 1FUOA 1TJ7A 4ADLA 4NSLA 2PTSA 2RJSA 2O7EA 4HGVA 2RJRA 2VD6A 4V2RA 1T6PA 5D6BA 2O7DA 3TV2A 1I0AA 4C5RA 2OHYA 2E9FA 3R6VA 1GKMA 3GZHA 1TJWA 4APBA 4FLCA 5HW2A 1JSWA 1HY1A 2PTRA 1TJVA 1XWOA 1U16A 4FFXA 4CQ5A 5F92A 4BAAA 1C3UA 2PFMA 2X75A 1DCNA 1T6JA 1HY0A 4C5SA 1C3CA 1W27A 3RD8A 1FUQA 1Y2MA 2YIIA 1YFEA 1K7WA 4NLEA 1FUPA 4APAA 3C8TA 3QBPA 3UNVA 1AUWA 3CZOA 2NYFA 1GKJA 1DOFA 4EFCA 4C5UA 2NYNA 3GTDA 3E04A 4EEIA 1EB4A 3BHGA 1FURA 3NO9A 3R6YA 2O7BA 5EYTA 2J91A 4MX2A 2O78A 1KQ7A 2HVGA 4V2QA 1U15A 3OCFA 3R6QA 1TJUA 1RE5A 4ADMA 1VDKA 4BABA 1YFMA 2PTQA 1GK2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1GK3 A;  1Q5N A;  3NZ4 A;  3KDZ A;  3OCE A;  2O7F A;  1B8F A;  2QVE A;  3RRP A;  5F91 A;  1YIS A;  5EYV A;  2O6Y A;  2QGA B;  1K62 A;  2FUS A;  3KDY A;  4C6G A;  1J3U A;  1FUO A;  1TJ7 A;  4ADL A;  4NSL A;  2PTS A;  2RJS A;  2O7E A;  4HGV A;  2RJR A;  2VD6 A;  4V2R A;  1T6P A;  5D6B A;  2O7D A;  3TV2 A;  1I0A A;  4C5R A;  2OHY A;  2E9F A;  3R6V A;  1GKM A;  3GZH A;  1TJW A;  4APB A;  4FLC A;  5HW2 A;  1JSW A;  1HY1 A;  2PTR A;  1TJV A;  1XWO A;  1U16 A;  4FFX A;  4CQ5 A;  5F92 A;  4BAA A;  1C3U A;  2PFM A;  2X75 A;  1DCN A;  1T6J A;  1HY0 A;  4C5S A;  1C3C A;  1W27 A;  3RD8 A;  1FUQ A;  1Y2M A;  2YII A;  1YFE A;  1K7W A;  4NLE A;  1FUP A;  4APA A;  3C8T A;  3QBP A;  3UNV A;  1AUW A;  3CZO A;  2NYF A;  1GKJ A;  1DOF A;  4EFC A;  4C5U A;  2NYN A;  3GTD A;  3E04 A;  4EEI A;  1EB4 A;  3BHG A;  1FUR A;  3NO9 A;  3R6Y A;  2O7B A;  5EYT A;  2J91 A;  4MX2 A;  2O78 A;  1KQ7 A;  2HVG A;  4V2Q A;  1U15 A;  3OCF A;  3R6Q A;  1TJU A;  1RE5 A;  4ADM A;  1VDK A;  4BAB A;  1YFM A;  2PTQ A;  1GK2 A; 
#chains in the Genus database with same CATH topology
 2VUM A;  1GK3 A;  1Q5N A;  2N1D B;  3NZ4 A;  1Y1V A;  1SMY D;  3EZE A;  3CQZ A;  3EZB A;  1I50 A;  1ZYR D;  1WCM A;  3KDZ A;  3OCE A;  3GTK A;  2LYI A;  2O7F A;  1B8F A;  1HQM D;  2EZB A;  4CEH A;  3GTJ A;  2QVE A;  1I3Q A;  1YIS A;  5EYV A;  5F91 A;  3RRP A;  1XMC A;  2O6Y A;  2F5J A;  2QGA B;  3LRD A;  2B63 A;  4CEI A;  1K62 A;  2VL7 A;  2FUS A;  3KDY A;  2VSF A;  1GK2 A;  2EZA A;  4C6G A;  2K3O A;  1J3U A;  4QIW A;  1FUO A;  2MQA A;  2EZC A;  1TJ7 A;  4ADL A;  4NSL A;  2PTS A;  2RJS A;  2O7E A;  4HGV A;  2A6E D;  4FBS A;  3LR8 A;  2N3E A;  5M0J A;  2X0P A;  2RJR A;  2VD6 A;  3GTM A;  4V2R A;  2FEN A;  1T6P A;  5D6B A;  2O7D A;  3TV2 A;  3GTL A;  1I0A A;  4C5R A;  5IZ2 A;  4CEJ A;  2OHY A;  2E9F A;  3R6V A;  1GKM A;  2A69 D;  2K3Q A;  3GZH A;  1TJW A;  2MX8 A;  4APB A;  3LR2 A;  2R7Z A;  1IW7 D;  2CW0 D;  4FLC A;  5HW2 A;  1JSW A;  2JA5 A;  3LR6 A;  2MP0 A;  1HY1 A;  2PTR A;  1TWF A;  1R9T A;  1TWA A;  1TJV A;  1XWO A;  2LKM B;  2R92 A;  1U16 A;  3GTO A;  1TWG A;  2LPJ A;  4FFX A;  4CQ5 A;  2E2H A;  1I6V D;  3GTP A;  2FEL A;  1YNJ D;  4C2M A;  5M0I A;  5F92 A;  4BAA A;  2JA7 A;  1K83 A;  1XMD A;  1C3U A;  2NVX A;  3GTG A;  2K3N A;  2PFM A;  2X75 A;  1DCN A;  1TWH A;  1T6J A;  2LTH A;  1HY0 A;  4C5S A;  4WNL A;  2A6H D;  3GTQ A;  5H8W A;  1W27 A;  1C3C A;  2A68 D;  2X0O A;  1FUQ A;  1Y2M A;  2HWG A;  1ZYM A;  3EZA A;  3RD8 A;  2YII A;  1YFE A;  2R93 A;  2BE5 D;  1K7W A;  4NLE A;  2YU9 A;  3FKI A;  1FUP A;  4APA A;  3C8T A;  3QBP A;  1XL8 A;  2X0Q A;  3UNV A;  3U4Q A;  1EZA A;  3U44 A;  1Y1W A;  1AUW A;  3CZO A;  2NYF A;  1GKJ A;  1DOF A;  4EFC A;  2O5J D;  2NVY A;  3CRV A;  4C5U A;  1SFO A;  2NYN A;  3GTD A;  3E04 A;  4EEI A;  2VK9 A;  1EB4 A;  3H0G A;  1FUR A;  3BHG A;  3NO9 A;  3R6Y A;  2O7B A;  5EYT A;  2HRO A;  2J91 A;  4MX2 A;  2FIO A;  2Y0N A;  1XL7 A;  2MX9 A;  2O78 A;  1KQ7 A;  2HVG A;  4A15 A;  2LPI A;  4V2Q A;  1U15 A;  3CRW 1;  1XLY A;  3OCF A;  2JA6 A;  3R6Q A;  1TJU A;  1RE5 A;  2FIP A;  4ADM A;  1VDK A;  4BAB A;  1EZB A;  1YFM A;  2PTQ A;  1YNN D;  1TWC A;  2E2I A;  2AQL A; 
#chains in the Genus database with same CATH homology
 1GK3 A;  1Q5N A;  3NZ4 A;  3KDZ A;  3OCE A;  2O7F A;  1B8F A;  2QVE A;  3RRP A;  5F91 A;  1YIS A;  5EYV A;  2O6Y A;  2QGA B;  1K62 A;  2FUS A;  3KDY A;  4C6G A;  1J3U A;  1FUO A;  1TJ7 A;  4ADL A;  4NSL A;  2PTS A;  2RJS A;  2O7E A;  4HGV A;  2RJR A;  2VD6 A;  4V2R A;  1T6P A;  5D6B A;  2O7D A;  3TV2 A;  1I0A A;  4C5R A;  2OHY A;  2E9F A;  3R6V A;  1GKM A;  3GZH A;  1TJW A;  4APB A;  4FLC A;  5HW2 A;  1JSW A;  1HY1 A;  2PTR A;  1TJV A;  1XWO A;  1U16 A;  4FFX A;  4CQ5 A;  5F92 A;  4BAA A;  1C3U A;  2PFM A;  2X75 A;  1DCN A;  1T6J A;  1HY0 A;  4C5S A;  1C3C A;  1W27 A;  3RD8 A;  1FUQ A;  1Y2M A;  2YII A;  1YFE A;  1K7W A;  4NLE A;  1FUP A;  4APA A;  3C8T A;  3QBP A;  3UNV A;  1AUW A;  3CZO A;  2NYF A;  1GKJ A;  1DOF A;  4EFC A;  4C5U A;  2NYN A;  3GTD A;  3E04 A;  4EEI A;  1EB4 A;  3BHG A;  1FUR A;  3NO9 A;  3R6Y A;  2O7B A;  5EYT A;  2J91 A;  4MX2 A;  2O78 A;  1KQ7 A;  2HVG A;  4V2Q A;  1U15 A;  3OCF A;  3R6Q A;  1TJU A;  1RE5 A;  4ADM A;  1VDK A;  4BAB A;  1YFM A;  2PTQ A;  1GK2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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