2YIIA

Manipulating the regioselectivity of phenylalanine aminomutase: new insights into the reaction mechanism of mio-dependent enzymes from structure-guided directed evolution
Total Genus 260
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
260
sequence length
667
structure length
643
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTKVDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHKDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Mechanism-Inspired Engineering of Phenylalanine Aminomutase for Enhanced Beta-Regioselective Asymmetric Amination of Cinnamates.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE
total genus 260
structure length 643
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2011-05-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 2yiiA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2yiiA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2yiiA02
4BAAA 1I0AA 2O6YA 4APAA 2J91A 3TV2A 2O7FA 2HVGA 1B8FA 1T6JA 3NO9A 2O7DA 5F92A 3R6YA 3UNVA 2QVEA 1HY1A 2PTSA 2O78A 1HY0A 1J3UA 3E04A 4ADMA 4HGVA 1FUQA 5EYTA 2PTRA 3KDZA 1YFEA 2O7EA 3OCFA 2PFMA 2E9FA 2NYNA 4MX2A 3NZ4A 1YFMA 1GKJA 2OHYA 1GK3A 4C6GA 2O7BA 4APBA 2RJSA 3R6QA 1AUWA 3RRPA 5F91A 4FFXA 3CZOA 1EB4A 1K7WA 2VD6A 1GK2A 3QBPA 1KQ7A 1TJUA 4NLEA 1DOFA 2YIIA 4EFCA 1XWOA 4BABA 4C5UA 1VDKA 2QGAB 1C3UA 3GTDA 4CQ5A 1Y2MA 1FUOA 3R6VA 1K62A 1FURA 4C5RA 4ADLA 1JSWA 4FLCA 1FUPA 4EEIA 1T6PA 1TJWA 2FUSA 3GZHA 1GKMA 2PTQA 3KDYA 3RD8A 4V2QA 1YISA 1W27A 1TJVA 1U16A 1C3CA 1RE5A 4V2RA 5D6BA 2RJRA 5HW2A 5EYVA 1Q5NA 2X75A 1TJ7A 1DCNA 4C5SA 4NSLA 3OCEA 3BHGA 3C8TA 1U15A 2NYFA
chains in the Genus database with same CATH superfamily
2LYIA 2R7ZA 4BAAA 3LR2A 1I0AA 2O6YA 2FIPA 2J91A 4APAA 3TV2A 2MQAA 2O7FA 2HVGA 1B8FA 1T6JA 2LKMB 2F5JA 4CEHA 3NO9A 3LRDA 1Y1VA 3H0GA 2O7DA 5F92A 2N3EA 3U4QA 2BE5D 2A6HD 2VK9A 3R6YA 3UNVA 2QVEA 1HY1A 3GTGA 2PTSA 3GTKA 1ZYMA 2O78A 5M0JA 1HY0A 1J3UA 2N1DB 3E04A 4HGVA 4ADMA 2X0PA 1FUQA 5IZ2A 3LR6A 5EYTA 2PTRA 3KDZA 3GTMA 1YFEA 2FELA 2O7EA 3OCFA 4WNLA 3LR8A 2E9FA 1YNND 2PFMA 1HQMD 2NYNA 4MX2A 2EZAA 2MX8A 3GTJA 3NZ4A 2K3OA 2YU9A 1YFMA 4CEIA 1GKJA 3EZEA 1U15A 1EZAA 2OHYA 1GK3A 4C6GA 2B63A 2VL7A 2A69D 4FBSA 3U44A 3C8TA 2FENA 2O7BA 3GTQA 2RJSA 3R6QA 4APBA 2JA6A 2MX9A 1AUWA 4A15A 2VSFA 3RRPA 2Y0NA 5F91A 4FFXA 2K3QA 3CRW1 2LPIA 1EB4A 3CZOA 1K7WA 2VD6A 1GK2A 1TWHA 3QBPA 2MP0A 1TWFA 1KQ7A 1SFOA 1TJUA 2NVYA 1XL7A 3EZAA 1XMDA 4NLEA 1DOFA 2YIIA 4EFCA 2HROA 1XWOA 2R92A 4BABA 2AQLA 4C5UA 1VDKA 2QGAB 5M0IA 1C3UA 3GTDA 4CQ5A 2FIOA 1Y2MA 1XMCA 1I50A 1FUOA 3R6VA 4C2MA 1I6VD 1K62A 2EZBA 4QIWA 1FURA 4C5RA 4ADLA 1JSWA 4FLCA 3FKIA 1FUPA 2EZCA 3CQZA 1ZYRD 5H8WA 4EEIA 3CRVA 1T6PA 1TJWA 2FUSA 3GTOA 3GZHA 1WCMA 1IW7D 1SMYD 2O5JD 1I3QA 2A6ED 2CW0D 1GKMA 2R93A 2NVXA 2PTQA 2E2HA 2HWGA 3KDYA 1TWCA 2LPJA 1TWAA 4V2QA 2LTHA 2JA7A 3RD8A 1YISA 2K3NA 1W27A 2X0QA 2X0OA 1EZBA 1R9TA 1C3CA 1TJVA 1U16A 1XLYA 1RE5A 1Y1WA 4V2RA 5D6BA 1XL8A 2JA5A 1YNJD 2RJRA 5HW2A 5EYVA 1TWGA 1Q5NA 2X75A 1K83A 2A68D 1TJ7A 3EZBA 1DCNA 4C5SA 3GTLA 4CEJA 4NSLA 3OCEA 2E2IA 3BHGA 2VUMA 3GTPA 2NYFA
chains in the Genus database with same CATH topology
4BAAA 1I0AA 2O6YA 4APAA 2J91A 3TV2A 2O7FA 2HVGA 1B8FA 1T6JA 3NO9A 2O7DA 5F92A 3R6YA 3UNVA 2QVEA 1HY1A 2PTSA 2O78A 1HY0A 1J3UA 3E04A 4ADMA 4HGVA 1FUQA 5EYTA 2PTRA 3KDZA 1YFEA 2O7EA 3OCFA 2PFMA 2E9FA 2NYNA 4MX2A 3NZ4A 1YFMA 1GKJA 2OHYA 1GK3A 4C6GA 2O7BA 4APBA 2RJSA 3R6QA 1AUWA 3RRPA 5F91A 4FFXA 3CZOA 1EB4A 1K7WA 2VD6A 1GK2A 3QBPA 1KQ7A 1TJUA 4NLEA 1DOFA 2YIIA 4EFCA 1XWOA 4BABA 4C5UA 1VDKA 2QGAB 1C3UA 3GTDA 4CQ5A 1Y2MA 1FUOA 3R6VA 1K62A 1FURA 4C5RA 4ADLA 1JSWA 4FLCA 1FUPA 4EEIA 1T6PA 1TJWA 2FUSA 3GZHA 1GKMA 2PTQA 3KDYA 3RD8A 4V2QA 1YISA 1W27A 1TJVA 1U16A 1C3CA 1RE5A 4V2RA 5D6BA 2RJRA 5HW2A 5EYVA 1Q5NA 2X75A 1TJ7A 1DCNA 4C5SA 4NSLA 3OCEA 3BHGA 3C8TA 1U15A 2NYFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BAA A;  1I0A A;  2O6Y A;  4APA A;  2J91 A;  3TV2 A;  2O7F A;  2HVG A;  1B8F A;  1T6J A;  3NO9 A;  2O7D A;  5F92 A;  3R6Y A;  3UNV A;  2QVE A;  1HY1 A;  2PTS A;  2O78 A;  1HY0 A;  1J3U A;  3E04 A;  4ADM A;  4HGV A;  1FUQ A;  5EYT A;  2PTR A;  3KDZ A;  1YFE A;  2O7E A;  3OCF A;  2PFM A;  2E9F A;  2NYN A;  4MX2 A;  3NZ4 A;  1YFM A;  1GKJ A;  2OHY A;  1GK3 A;  4C6G A;  2O7B A;  4APB A;  2RJS A;  3R6Q A;  1AUW A;  3RRP A;  5F91 A;  4FFX A;  3CZO A;  1EB4 A;  1K7W A;  2VD6 A;  1GK2 A;  3QBP A;  1KQ7 A;  1TJU A;  4NLE A;  1DOF A;  2YII A;  4EFC A;  1XWO A;  4BAB A;  4C5U A;  1VDK A;  2QGA B;  1C3U A;  3GTD A;  4CQ5 A;  1Y2M A;  1FUO A;  3R6V A;  1K62 A;  1FUR A;  4C5R A;  4ADL A;  1JSW A;  4FLC A;  1FUP A;  4EEI A;  1T6P A;  1TJW A;  2FUS A;  3GZH A;  1GKM A;  2PTQ A;  3KDY A;  3RD8 A;  4V2Q A;  1YIS A;  1W27 A;  1TJV A;  1U16 A;  1C3C A;  1RE5 A;  4V2R A;  5D6B A;  2RJR A;  5HW2 A;  5EYV A;  1Q5N A;  2X75 A;  1TJ7 A;  1DCN A;  4C5S A;  4NSL A;  3OCE A;  3BHG A;  3C8T A;  1U15 A;  2NYF A; 
#chains in the Genus database with same CATH topology
 2LYI A;  2R7Z A;  4BAA A;  3LR2 A;  1I0A A;  2O6Y A;  2FIP A;  2J91 A;  4APA A;  3TV2 A;  2MQA A;  2O7F A;  2HVG A;  1B8F A;  1T6J A;  2LKM B;  2F5J A;  4CEH A;  3NO9 A;  3LRD A;  1Y1V A;  3H0G A;  2O7D A;  5F92 A;  2N3E A;  3U4Q A;  2BE5 D;  2A6H D;  2VK9 A;  3R6Y A;  3UNV A;  2QVE A;  1HY1 A;  3GTG A;  2PTS A;  3GTK A;  1ZYM A;  2O78 A;  5M0J A;  1HY0 A;  1J3U A;  2N1D B;  3E04 A;  4HGV A;  4ADM A;  2X0P A;  1FUQ A;  5IZ2 A;  3LR6 A;  5EYT A;  2PTR A;  3KDZ A;  3GTM A;  1YFE A;  2FEL A;  2O7E A;  3OCF A;  4WNL A;  3LR8 A;  2E9F A;  1YNN D;  2PFM A;  1HQM D;  2NYN A;  4MX2 A;  2EZA A;  2MX8 A;  3GTJ A;  3NZ4 A;  2K3O A;  2YU9 A;  1YFM A;  4CEI A;  1GKJ A;  3EZE A;  1U15 A;  1EZA A;  2OHY A;  1GK3 A;  4C6G A;  2B63 A;  2VL7 A;  2A69 D;  4FBS A;  3U44 A;  3C8T A;  2FEN A;  2O7B A;  3GTQ A;  2RJS A;  3R6Q A;  4APB A;  2JA6 A;  2MX9 A;  1AUW A;  4A15 A;  2VSF A;  3RRP A;  2Y0N A;  5F91 A;  4FFX A;  2K3Q A;  3CRW 1;  2LPI A;  1EB4 A;  3CZO A;  1K7W A;  2VD6 A;  1GK2 A;  1TWH A;  3QBP A;  2MP0 A;  1TWF A;  1KQ7 A;  1SFO A;  1TJU A;  2NVY A;  1XL7 A;  3EZA A;  1XMD A;  4NLE A;  1DOF A;  2YII A;  4EFC A;  2HRO A;  1XWO A;  2R92 A;  4BAB A;  2AQL A;  4C5U A;  1VDK A;  2QGA B;  5M0I A;  1C3U A;  3GTD A;  4CQ5 A;  2FIO A;  1Y2M A;  1XMC A;  1I50 A;  1FUO A;  3R6V A;  4C2M A;  1I6V D;  1K62 A;  2EZB A;  4QIW A;  1FUR A;  4C5R A;  4ADL A;  1JSW A;  4FLC A;  3FKI A;  1FUP A;  2EZC A;  3CQZ A;  1ZYR D;  5H8W A;  4EEI A;  3CRV A;  1T6P A;  1TJW A;  2FUS A;  3GTO A;  3GZH A;  1WCM A;  1IW7 D;  1SMY D;  2O5J D;  1I3Q A;  2A6E D;  2CW0 D;  1GKM A;  2R93 A;  2NVX A;  2PTQ A;  2E2H A;  2HWG A;  3KDY A;  1TWC A;  2LPJ A;  1TWA A;  4V2Q A;  2LTH A;  2JA7 A;  3RD8 A;  1YIS A;  2K3N A;  1W27 A;  2X0Q A;  2X0O A;  1EZB A;  1R9T A;  1C3C A;  1TJV A;  1U16 A;  1XLY A;  1RE5 A;  1Y1W A;  4V2R A;  5D6B A;  1XL8 A;  2JA5 A;  1YNJ D;  2RJR A;  5HW2 A;  5EYV A;  1TWG A;  1Q5N A;  2X75 A;  1K83 A;  2A68 D;  1TJ7 A;  3EZB A;  1DCN A;  4C5S A;  3GTL A;  4CEJ A;  4NSL A;  3OCE A;  2E2I A;  3BHG A;  2VUM A;  3GTP A;  2NYF A; 
#chains in the Genus database with same CATH homology
 4BAA A;  1I0A A;  2O6Y A;  4APA A;  2J91 A;  3TV2 A;  2O7F A;  2HVG A;  1B8F A;  1T6J A;  3NO9 A;  2O7D A;  5F92 A;  3R6Y A;  3UNV A;  2QVE A;  1HY1 A;  2PTS A;  2O78 A;  1HY0 A;  1J3U A;  3E04 A;  4ADM A;  4HGV A;  1FUQ A;  5EYT A;  2PTR A;  3KDZ A;  1YFE A;  2O7E A;  3OCF A;  2PFM A;  2E9F A;  2NYN A;  4MX2 A;  3NZ4 A;  1YFM A;  1GKJ A;  2OHY A;  1GK3 A;  4C6G A;  2O7B A;  4APB A;  2RJS A;  3R6Q A;  1AUW A;  3RRP A;  5F91 A;  4FFX A;  3CZO A;  1EB4 A;  1K7W A;  2VD6 A;  1GK2 A;  3QBP A;  1KQ7 A;  1TJU A;  4NLE A;  1DOF A;  2YII A;  4EFC A;  1XWO A;  4BAB A;  4C5U A;  1VDK A;  2QGA B;  1C3U A;  3GTD A;  4CQ5 A;  1Y2M A;  1FUO A;  3R6V A;  1K62 A;  1FUR A;  4C5R A;  4ADL A;  1JSW A;  4FLC A;  1FUP A;  4EEI A;  1T6P A;  1TJW A;  2FUS A;  3GZH A;  1GKM A;  2PTQ A;  3KDY A;  3RD8 A;  4V2Q A;  1YIS A;  1W27 A;  1TJV A;  1U16 A;  1C3C A;  1RE5 A;  4V2R A;  5D6B A;  2RJR A;  5HW2 A;  5EYV A;  1Q5N A;  2X75 A;  1TJ7 A;  1DCN A;  4C5S A;  4NSL A;  3OCE A;  3BHG A;  3C8T A;  1U15 A;  2NYF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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