2YIIA

Manipulating the regioselectivity of phenylalanine aminomutase: new insights into the reaction mechanism of mio-dependent enzymes from structure-guided directed evolution
Total Genus 260
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
260
sequence length
667
structure length
643
Chain Sequence
b'SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTKVDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHKDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMMONIA-LYASE
publication title Mechanism-Inspired Engineering of Phenylalanine Aminomutase for Enhanced Beta-Regioselective Asymmetric Amination of Cinnamates.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 260
structure length 643
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2011-05-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 2yiiA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2yiiA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2yiiA02
2NYFA 1TJVA 4NLEA 1TJWA 1TJUA 1C3CA 5F91A 5EYTA 1U15A 4MX2A 3UNVA 4BABA 4APBA 4V2QA 3QBPA 1TJ7A 3RD8A 2OHYA 1XWOA 1GK3A 1C3UA 1DOFA 1GKJA 1K62A 3CZOA 1W27A 1YFEA 3OCEA 4C6GA 3NO9A 1FUOA 2YIIA 2O7EA 3R6QA 4FFXA 4BAAA 1B8FA 2O7BA 3OCFA 4C5SA 4C5UA 1FUPA 1GKMA 5D6BA 3KDYA 1T6PA 1VDKA 4EFCA 4C5RA 4ADMA 5F92A 2O78A 2QVEA 3GZHA 3NZ4A 1J3UA 5EYVA 4CQ5A 1T6JA 5HW2A 1RE5A 4NSLA 3TV2A 2E9FA 2RJRA 1U16A 1YFMA 2NYNA 2PTRA 3BHGA 1K7WA 2PTSA 1Q5NA 1KQ7A 1JSWA 1HY1A 2J91A 3E04A 1YISA 3R6YA 4APAA 4ADLA 3GTDA 2O7DA 1FURA 2RJSA 3RRPA 2HVGA 1HY0A 2PTQA 4V2RA 2VD6A 2FUSA 2PFMA 4FLCA 1GK2A 4EEIA 1DCNA 1FUQA 2X75A 3C8TA 1Y2MA 1EB4A 2O7FA 4HGVA 3R6VA 1I0AA 2O6YA 3KDZA 2QGAB 1AUWA
chains in the Genus database with same CATH superfamily
2EZAA 2NYFA 3GTOA 2MX8A 1TJVA 1YNND 2VK9A 4NLEA 1K83A 1TJWA 2B63A 1TJUA 1XMDA 3LRDA 1C3CA 5F91A 5H8WA 5EYTA 2CW0D 4A15A 1U15A 4MX2A 3UNVA 3U4QA 4BABA 4APBA 4V2QA 2VUMA 3QBPA 1TJ7A 3RD8A 1TWGA 2O5JD 1TWAA 1YNJD 2VL7A 2K3NA 2OHYA 4QIWA 1XWOA 1GK3A 1C3UA 1DOFA 2X0QA 1Y1VA 1GKJA 1K62A 3CZOA 1W27A 5IZ2A 1YFEA 3OCEA 1I3QA 4C6GA 3NO9A 1FUOA 2AQLA 2YIIA 4CEJA 2O7EA 3R6QA 2R93A 2HROA 4FFXA 1EZAA 4BAAA 1SMYD 2JA6A 2FENA 1B8FA 2O7BA 3OCFA 4FBSA 4C5SA 1XMCA 2FELA 1IW7D 4C5UA 1FUPA 3LR6A 1GKMA 5D6BA 1HQMD 3KDYA 3GTGA 1T6PA 2YU9A 1Y1WA 1VDKA 2BE5D 4EFCA 4C5RA 1TWCA 1SFOA 4ADMA 2O78A 2QVEA 3GZHA 3NZ4A 5F92A 2R7ZA 1J3UA 5EYVA 5M0JA 3GTKA 2EZBA 2NVXA 1XL8A 1WCMA 4CQ5A 1T6JA 3LR8A 5HW2A 2LTHA 1RE5A 2K3QA 2LYIA 2JA7A 3CRW1 4NSLA 1TWFA 3CRVA 3TV2A 2E9FA 2LPIA 2RJRA 2MQAA 2NVYA 1R9TA 1U16A 1TWHA 1AUWA 3EZAA 2A69D 1XLYA 2N3EA 3GTPA 1YFMA 2HWGA 2K3OA 2MX9A 3GTMA 2NYNA 2PTRA 3BHGA 1K7WA 4WNLA 2E2IA 2PTSA 1Q5NA 1KQ7A 1JSWA 1HY1A 2JA5A 1ZYRD 2F5JA 1I50A 2J91A 3E04A 2LKMB 2VSFA 2A6ED 1YISA 1ZYMA 3R6YA 3U44A 4ADLA 3EZEA 4APAA 3GTDA 2O7DA 1EZBA 1FURA 2RJSA 3KDZA 2EZCA 3RRPA 2HVGA 1HY0A 2PTQA 4V2RA 2VD6A 3H0GA 2FUSA 2X0OA 4C2MA 2LPJA 2PFMA 1GK2A 4FLCA 2FIPA 2E2HA 3LR2A 2R92A 2Y0NA 3EZBA 3GTQA 2X0PA 4EEIA 2A68D 1XL7A 2N1DB 1DCNA 1FUQA 2X75A 3C8TA 1Y2MA 1EB4A 2O7FA 4HGVA 3R6VA 1I0AA 1I6VD 2FIOA 3GTJA 4CEHA 3GTLA 2O6YA 4CEIA 3FKIA 5M0IA 3CQZA 2QGAB 2A6HD 2MP0A
chains in the Genus database with same CATH topology
2NYFA 1TJVA 4NLEA 1TJWA 1TJUA 1C3CA 5F91A 5EYTA 1U15A 4MX2A 3UNVA 4BABA 4APBA 4V2QA 3QBPA 1TJ7A 3RD8A 2OHYA 1XWOA 1GK3A 1C3UA 1DOFA 1GKJA 1K62A 3CZOA 1W27A 1YFEA 3OCEA 4C6GA 3NO9A 1FUOA 2YIIA 2O7EA 3R6QA 4FFXA 4BAAA 1B8FA 2O7BA 3OCFA 4C5SA 4C5UA 1FUPA 1GKMA 5D6BA 3KDYA 1T6PA 1VDKA 4EFCA 4C5RA 4ADMA 5F92A 2O78A 2QVEA 3GZHA 3NZ4A 1J3UA 5EYVA 4CQ5A 1T6JA 5HW2A 1RE5A 4NSLA 3TV2A 2E9FA 2RJRA 1U16A 1YFMA 2NYNA 2PTRA 3BHGA 1K7WA 2PTSA 1Q5NA 1KQ7A 1JSWA 1HY1A 2J91A 3E04A 1YISA 3R6YA 4APAA 4ADLA 3GTDA 2O7DA 1FURA 2RJSA 3RRPA 2HVGA 1HY0A 2PTQA 4V2RA 2VD6A 2FUSA 2PFMA 4FLCA 1GK2A 4EEIA 1DCNA 1FUQA 2X75A 3C8TA 1Y2MA 1EB4A 2O7FA 4HGVA 3R6VA 1I0AA 2O6YA 3KDZA 2QGAB 1AUWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NYF A;  1TJV A;  4NLE A;  1TJW A;  1TJU A;  1C3C A;  5F91 A;  5EYT A;  1U15 A;  4MX2 A;  3UNV A;  4BAB A;  4APB A;  4V2Q A;  3QBP A;  1TJ7 A;  3RD8 A;  2OHY A;  1XWO A;  1GK3 A;  1C3U A;  1DOF A;  1GKJ A;  1K62 A;  3CZO A;  1W27 A;  1YFE A;  3OCE A;  4C6G A;  3NO9 A;  1FUO A;  2YII A;  2O7E A;  3R6Q A;  4FFX A;  4BAA A;  1B8F A;  2O7B A;  3OCF A;  4C5S A;  4C5U A;  1FUP A;  1GKM A;  5D6B A;  3KDY A;  1T6P A;  1VDK A;  4EFC A;  4C5R A;  4ADM A;  5F92 A;  2O78 A;  2QVE A;  3GZH A;  3NZ4 A;  1J3U A;  5EYV A;  4CQ5 A;  1T6J A;  5HW2 A;  1RE5 A;  4NSL A;  3TV2 A;  2E9F A;  2RJR A;  1U16 A;  1YFM A;  2NYN A;  2PTR A;  3BHG A;  1K7W A;  2PTS A;  1Q5N A;  1KQ7 A;  1JSW A;  1HY1 A;  2J91 A;  3E04 A;  1YIS A;  3R6Y A;  4APA A;  4ADL A;  3GTD A;  2O7D A;  1FUR A;  2RJS A;  3RRP A;  2HVG A;  1HY0 A;  2PTQ A;  4V2R A;  2VD6 A;  2FUS A;  2PFM A;  4FLC A;  1GK2 A;  4EEI A;  1DCN A;  1FUQ A;  2X75 A;  3C8T A;  1Y2M A;  1EB4 A;  2O7F A;  4HGV A;  3R6V A;  1I0A A;  2O6Y A;  3KDZ A;  2QGA B;  1AUW A; 
#chains in the Genus database with same CATH topology
 2EZA A;  2NYF A;  3GTO A;  2MX8 A;  1TJV A;  1YNN D;  2VK9 A;  4NLE A;  1K83 A;  1TJW A;  2B63 A;  1TJU A;  1XMD A;  3LRD A;  1C3C A;  5F91 A;  5H8W A;  5EYT A;  2CW0 D;  4A15 A;  1U15 A;  4MX2 A;  3UNV A;  3U4Q A;  4BAB A;  4APB A;  4V2Q A;  2VUM A;  3QBP A;  1TJ7 A;  3RD8 A;  1TWG A;  2O5J D;  1TWA A;  1YNJ D;  2VL7 A;  2K3N A;  2OHY A;  4QIW A;  1XWO A;  1GK3 A;  1C3U A;  1DOF A;  2X0Q A;  1Y1V A;  1GKJ A;  1K62 A;  3CZO A;  1W27 A;  5IZ2 A;  1YFE A;  3OCE A;  1I3Q A;  4C6G A;  3NO9 A;  1FUO A;  2AQL A;  2YII A;  4CEJ A;  2O7E A;  3R6Q A;  2R93 A;  2HRO A;  4FFX A;  1EZA A;  4BAA A;  1SMY D;  2JA6 A;  2FEN A;  1B8F A;  2O7B A;  3OCF A;  4FBS A;  4C5S A;  1XMC A;  2FEL A;  1IW7 D;  4C5U A;  1FUP A;  3LR6 A;  1GKM A;  5D6B A;  1HQM D;  3KDY A;  3GTG A;  1T6P A;  2YU9 A;  1Y1W A;  1VDK A;  2BE5 D;  4EFC A;  4C5R A;  1TWC A;  1SFO A;  4ADM A;  2O78 A;  2QVE A;  3GZH A;  3NZ4 A;  5F92 A;  2R7Z A;  1J3U A;  5EYV A;  5M0J A;  3GTK A;  2EZB A;  2NVX A;  1XL8 A;  1WCM A;  4CQ5 A;  1T6J A;  3LR8 A;  5HW2 A;  2LTH A;  1RE5 A;  2K3Q A;  2LYI A;  2JA7 A;  3CRW 1;  4NSL A;  1TWF A;  3CRV A;  3TV2 A;  2E9F A;  2LPI A;  2RJR A;  2MQA A;  2NVY A;  1R9T A;  1U16 A;  1TWH A;  1AUW A;  3EZA A;  2A69 D;  1XLY A;  2N3E A;  3GTP A;  1YFM A;  2HWG A;  2K3O A;  2MX9 A;  3GTM A;  2NYN A;  2PTR A;  3BHG A;  1K7W A;  4WNL A;  2E2I A;  2PTS A;  1Q5N A;  1KQ7 A;  1JSW A;  1HY1 A;  2JA5 A;  1ZYR D;  2F5J A;  1I50 A;  2J91 A;  3E04 A;  2LKM B;  2VSF A;  2A6E D;  1YIS A;  1ZYM A;  3R6Y A;  3U44 A;  4ADL A;  3EZE A;  4APA A;  3GTD A;  2O7D A;  1EZB A;  1FUR A;  2RJS A;  3KDZ A;  2EZC A;  3RRP A;  2HVG A;  1HY0 A;  2PTQ A;  4V2R A;  2VD6 A;  3H0G A;  2FUS A;  2X0O A;  4C2M A;  2LPJ A;  2PFM A;  1GK2 A;  4FLC A;  2FIP A;  2E2H A;  3LR2 A;  2R92 A;  2Y0N A;  3EZB A;  3GTQ A;  2X0P A;  4EEI A;  2A68 D;  1XL7 A;  2N1D B;  1DCN A;  1FUQ A;  2X75 A;  3C8T A;  1Y2M A;  1EB4 A;  2O7F A;  4HGV A;  3R6V A;  1I0A A;  1I6V D;  2FIO A;  3GTJ A;  4CEH A;  3GTL A;  2O6Y A;  4CEI A;  3FKI A;  5M0I A;  3CQZ A;  2QGA B;  2A6H D;  2MP0 A; 
#chains in the Genus database with same CATH homology
 2NYF A;  1TJV A;  4NLE A;  1TJW A;  1TJU A;  1C3C A;  5F91 A;  5EYT A;  1U15 A;  4MX2 A;  3UNV A;  4BAB A;  4APB A;  4V2Q A;  3QBP A;  1TJ7 A;  3RD8 A;  2OHY A;  1XWO A;  1GK3 A;  1C3U A;  1DOF A;  1GKJ A;  1K62 A;  3CZO A;  1W27 A;  1YFE A;  3OCE A;  4C6G A;  3NO9 A;  1FUO A;  2YII A;  2O7E A;  3R6Q A;  4FFX A;  4BAA A;  1B8F A;  2O7B A;  3OCF A;  4C5S A;  4C5U A;  1FUP A;  1GKM A;  5D6B A;  3KDY A;  1T6P A;  1VDK A;  4EFC A;  4C5R A;  4ADM A;  5F92 A;  2O78 A;  2QVE A;  3GZH A;  3NZ4 A;  1J3U A;  5EYV A;  4CQ5 A;  1T6J A;  5HW2 A;  1RE5 A;  4NSL A;  3TV2 A;  2E9F A;  2RJR A;  1U16 A;  1YFM A;  2NYN A;  2PTR A;  3BHG A;  1K7W A;  2PTS A;  1Q5N A;  1KQ7 A;  1JSW A;  1HY1 A;  2J91 A;  3E04 A;  1YIS A;  3R6Y A;  4APA A;  4ADL A;  3GTD A;  2O7D A;  1FUR A;  2RJS A;  3RRP A;  2HVG A;  1HY0 A;  2PTQ A;  4V2R A;  2VD6 A;  2FUS A;  2PFM A;  4FLC A;  1GK2 A;  4EEI A;  1DCN A;  1FUQ A;  2X75 A;  3C8T A;  1Y2M A;  1EB4 A;  2O7F A;  4HGV A;  3R6V A;  1I0A A;  2O6Y A;  3KDZ A;  2QGA B;  1AUW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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