1GKMA

Histidine ammonia-lyase (hal) from pseudomonas putida inhibited with l-cysteine
Total Genus 202
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
202
sequence length
507
structure length
506
Chain Sequence
TELTLKPGTLTLAQLRAIHAAPVRLQLDASAAPAIDASVACVEQIIAEDRTAYGINTGFGLLASTRIASHDLENLQRSLVLSHAAGIGAPLDDDLVRLIMVLKINSLSRGFSGIRRKVIDALIALVNAEVYPHIPLKGSVGDLAPLAHMSLVLLGEGKARYKGQWLSATEALAVAGLEPLTLAAKEGLALLNGTQASTAYALRGLFYAEDLYAAAIACGGLSVEAVLGSRSPFDARIHEARGQRGQIDTAACFRDLLGDSSEVSLSHKNADKVQDPYSLRCQPQVMGACLTQLRQAAEVLGIEANAVSDNPLVFAAEGDVISGGNFHAEPVAMAADNLALAIAEIGSLSERRISLMMDKHMSQLPPFLVENGGVNSGFMIAQVTAAALASENKALSHPHSVDSLPTSANQEDHVSMAPAAGKRLWEMAENTRGVLAIEWLGACQGLDLRKGLKTSAKLEKARQALRSEVAHYDRDRFFAPDIEKAVELLAKGSLTGLLPAGVLPSL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of Two Histidine Ammonia-Lyase Modifications and Implications for the Catalytic Mechanism
pubmed doi rcsb
molecule tags Lyase
source organism Pseudomonas putida
molecule keywords HISTIDINE AMMONIA-LYASE
total genus 202
structure length 506
sequence length 507
ec nomenclature ec 4.3.1.3: Histidine ammonia-lyase.
pdb deposition date 2001-08-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1gkmA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1gkmA02
1YFMA 4EEIA 1KQ7A 2QVEA 3R6YA 1HY0A 2RJRA 4V2RA 2E9FA 1B8FA 1GK3A 2YIIA 3OCFA 4C5UA 4C6GA 3UNVA 1VDKA 1YISA 2NYNA 2NYFA 2X75A 1GK2A 1I0AA 1FUQA 1C3CA 2PFMA 4C5SA 1DCNA 1J3UA 4CQ5A 2QGAB 3QBPA 5EYVA 4ADMA 5HW2A 3BHGA 1Y2MA 2O6YA 1JSWA 5F91A 3RRPA 1RE5A 1FUPA 1FURA 4FFXA 1YFEA 1FUOA 1XWOA 2O7BA 5EYTA 4APBA 5D6BA 4MX2A 4BABA 1Q5NA 1EB4A 3OCEA 4ADLA 4NSLA 1TJWA 4BAAA 3CZOA 5F92A 2O7DA 1GKMA 3GZHA 2RJSA 3TV2A 3R6VA 4NLEA 1AUWA 3GTDA 4C5RA 4FLCA 1T6JA 2PTSA 1K7WA 2O7FA 2FUSA 1DOFA 2O78A 2HVGA 3NO9A 1TJVA 3C8TA 1HY1A 4V2QA 4HGVA 2PTRA 3R6QA 3NZ4A 3KDYA 2OHYA 3KDZA 1U15A 2J91A 3E04A 1TJ7A 3RD8A 4APAA 2O7EA 1W27A 1T6PA 2PTQA 1K62A 1U16A 1TJUA 4EFCA 1C3UA 2VD6A 1GKJA
chains in the Genus database with same CATH superfamily
1YFMA 4EEIA 1KQ7A 2QVEA 3R6YA 1HY0A 2RJRA 1XLYA 2E9FA 4V2RA 1B8FA 1GK3A 2YIIA 3OCFA 4C5UA 4C6GA 4WNLA 3UNVA 1VDKA 1YISA 2NYNA 2NYFA 2X75A 1GK2A 1I0AA 1XMCA 1FUQA 1C3CA 2PFMA 4C5SA 1DCNA 1J3UA 4CQ5A 2QGAB 3QBPA 5EYVA 4ADMA 5HW2A 2FELA 3BHGA 1Y2MA 2O6YA 1JSWA 5F91A 3RRPA 1RE5A 1FUPA 1FURA 4FFXA 1YFEA 5H8WA 1FUOA 1XL7A 1XWOA 2O7BA 2FENA 2VL7A 4A15A 5EYTA 4APBA 5D6BA 4MX2A 4BABA 1Q5NA 1EB4A 3OCEA 4ADLA 4NSLA 1TJWA 4BAAA 3CZOA 5F92A 2O7DA 1GKMA 3GZHA 2RJSA 3TV2A 3R6VA 2VSFA 4NLEA 5M0JA 1AUWA 3GTDA 4C5RA 4FLCA 1T6JA 2PTSA 1K7WA 2O7FA 2FUSA 1DOFA 2O78A 2HVGA 3NO9A 1TJVA 3C8TA 1HY1A 4V2QA 5M0IA 4HGVA 2PTRA 3R6QA 3CRW1 3NZ4A 3KDYA 2OHYA 3KDZA 1U15A 2J91A 3E04A 1TJ7A 3RD8A 4APAA 2O7EA 1W27A 1T6PA 2PTQA 1XL8A 3CRVA 1K62A 1U16A 1XMDA 1TJUA 4EFCA 1C3UA 2VD6A 1GKJA
chains in the Genus database with same CATH topology
1YFMA 4EEIA 1KQ7A 2QVEA 3R6YA 1HY0A 2RJRA 4V2RA 2E9FA 1B8FA 1GK3A 2YIIA 3OCFA 4C5UA 4C6GA 3UNVA 1VDKA 1YISA 2NYNA 2NYFA 2X75A 1GK2A 1I0AA 1FUQA 1C3CA 2PFMA 4C5SA 1DCNA 1J3UA 4CQ5A 2QGAB 3QBPA 5EYVA 4ADMA 5HW2A 3BHGA 1Y2MA 2O6YA 1JSWA 5F91A 3RRPA 1RE5A 1FUPA 1FURA 4FFXA 1YFEA 1FUOA 1XWOA 2O7BA 5EYTA 4APBA 5D6BA 4MX2A 4BABA 1Q5NA 1EB4A 3OCEA 4ADLA 4NSLA 1TJWA 4BAAA 3CZOA 5F92A 2O7DA 1GKMA 3GZHA 2RJSA 3TV2A 3R6VA 4NLEA 1AUWA 3GTDA 4C5RA 4FLCA 1T6JA 2PTSA 1K7WA 2O7FA 2FUSA 1DOFA 2O78A 2HVGA 3NO9A 1TJVA 3C8TA 1HY1A 4V2QA 4HGVA 2PTRA 3R6QA 3NZ4A 3KDYA 2OHYA 3KDZA 1U15A 2J91A 3E04A 1TJ7A 3RD8A 4APAA 2O7EA 1W27A 1T6PA 2PTQA 1K62A 1U16A 1TJUA 4EFCA 1C3UA 2VD6A 1GKJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YFM A;  4EEI A;  1KQ7 A;  2QVE A;  3R6Y A;  1HY0 A;  2RJR A;  4V2R A;  2E9F A;  1B8F A;  1GK3 A;  2YII A;  3OCF A;  4C5U A;  4C6G A;  3UNV A;  1VDK A;  1YIS A;  2NYN A;  2NYF A;  2X75 A;  1GK2 A;  1I0A A;  1FUQ A;  1C3C A;  2PFM A;  4C5S A;  1DCN A;  1J3U A;  4CQ5 A;  2QGA B;  3QBP A;  5EYV A;  4ADM A;  5HW2 A;  3BHG A;  1Y2M A;  2O6Y A;  1JSW A;  5F91 A;  3RRP A;  1RE5 A;  1FUP A;  1FUR A;  4FFX A;  1YFE A;  1FUO A;  1XWO A;  2O7B A;  5EYT A;  4APB A;  5D6B A;  4MX2 A;  4BAB A;  1Q5N A;  1EB4 A;  3OCE A;  4ADL A;  4NSL A;  1TJW A;  4BAA A;  3CZO A;  5F92 A;  2O7D A;  1GKM A;  3GZH A;  2RJS A;  3TV2 A;  3R6V A;  4NLE A;  1AUW A;  3GTD A;  4C5R A;  4FLC A;  1T6J A;  2PTS A;  1K7W A;  2O7F A;  2FUS A;  1DOF A;  2O78 A;  2HVG A;  3NO9 A;  1TJV A;  3C8T A;  1HY1 A;  4V2Q A;  4HGV A;  2PTR A;  3R6Q A;  3NZ4 A;  3KDY A;  2OHY A;  3KDZ A;  1U15 A;  2J91 A;  3E04 A;  1TJ7 A;  3RD8 A;  4APA A;  2O7E A;  1W27 A;  1T6P A;  2PTQ A;  1K62 A;  1U16 A;  1TJU A;  4EFC A;  1C3U A;  2VD6 A;  1GKJ A; 
#chains in the Genus database with same CATH topology
 1YFM A;  4EEI A;  1KQ7 A;  2QVE A;  3R6Y A;  1HY0 A;  2RJR A;  1XLY A;  2E9F A;  4V2R A;  1B8F A;  1GK3 A;  2YII A;  3OCF A;  4C5U A;  4C6G A;  4WNL A;  3UNV A;  1VDK A;  1YIS A;  2NYN A;  2NYF A;  2X75 A;  1GK2 A;  1I0A A;  1XMC A;  1FUQ A;  1C3C A;  2PFM A;  4C5S A;  1DCN A;  1J3U A;  4CQ5 A;  2QGA B;  3QBP A;  5EYV A;  4ADM A;  5HW2 A;  2FEL A;  3BHG A;  1Y2M A;  2O6Y A;  1JSW A;  5F91 A;  3RRP A;  1RE5 A;  1FUP A;  1FUR A;  4FFX A;  1YFE A;  5H8W A;  1FUO A;  1XL7 A;  1XWO A;  2O7B A;  2FEN A;  2VL7 A;  4A15 A;  5EYT A;  4APB A;  5D6B A;  4MX2 A;  4BAB A;  1Q5N A;  1EB4 A;  3OCE A;  4ADL A;  4NSL A;  1TJW A;  4BAA A;  3CZO A;  5F92 A;  2O7D A;  1GKM A;  3GZH A;  2RJS A;  3TV2 A;  3R6V A;  2VSF A;  4NLE A;  5M0J A;  1AUW A;  3GTD A;  4C5R A;  4FLC A;  1T6J A;  2PTS A;  1K7W A;  2O7F A;  2FUS A;  1DOF A;  2O78 A;  2HVG A;  3NO9 A;  1TJV A;  3C8T A;  1HY1 A;  4V2Q A;  5M0I A;  4HGV A;  2PTR A;  3R6Q A;  3CRW 1;  3NZ4 A;  3KDY A;  2OHY A;  3KDZ A;  1U15 A;  2J91 A;  3E04 A;  1TJ7 A;  3RD8 A;  4APA A;  2O7E A;  1W27 A;  1T6P A;  2PTQ A;  1XL8 A;  3CRV A;  1K62 A;  1U16 A;  1XMD A;  1TJU A;  4EFC A;  1C3U A;  2VD6 A;  1GKJ A; 
#chains in the Genus database with same CATH homology
 1YFM A;  4EEI A;  1KQ7 A;  2QVE A;  3R6Y A;  1HY0 A;  2RJR A;  4V2R A;  2E9F A;  1B8F A;  1GK3 A;  2YII A;  3OCF A;  4C5U A;  4C6G A;  3UNV A;  1VDK A;  1YIS A;  2NYN A;  2NYF A;  2X75 A;  1GK2 A;  1I0A A;  1FUQ A;  1C3C A;  2PFM A;  4C5S A;  1DCN A;  1J3U A;  4CQ5 A;  2QGA B;  3QBP A;  5EYV A;  4ADM A;  5HW2 A;  3BHG A;  1Y2M A;  2O6Y A;  1JSW A;  5F91 A;  3RRP A;  1RE5 A;  1FUP A;  1FUR A;  4FFX A;  1YFE A;  1FUO A;  1XWO A;  2O7B A;  5EYT A;  4APB A;  5D6B A;  4MX2 A;  4BAB A;  1Q5N A;  1EB4 A;  3OCE A;  4ADL A;  4NSL A;  1TJW A;  4BAA A;  3CZO A;  5F92 A;  2O7D A;  1GKM A;  3GZH A;  2RJS A;  3TV2 A;  3R6V A;  4NLE A;  1AUW A;  3GTD A;  4C5R A;  4FLC A;  1T6J A;  2PTS A;  1K7W A;  2O7F A;  2FUS A;  1DOF A;  2O78 A;  2HVG A;  3NO9 A;  1TJV A;  3C8T A;  1HY1 A;  4V2Q A;  4HGV A;  2PTR A;  3R6Q A;  3NZ4 A;  3KDY A;  2OHY A;  3KDZ A;  1U15 A;  2J91 A;  3E04 A;  1TJ7 A;  3RD8 A;  4APA A;  2O7E A;  1W27 A;  1T6P A;  2PTQ A;  1K62 A;  1U16 A;  1TJU A;  4EFC A;  1C3U A;  2VD6 A;  1GKJ A; 
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