1GKMA

Histidine ammonia-lyase (hal) from pseudomonas putida inhibited with l-cysteine
Total Genus 202
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
202
sequence length
507
structure length
506
Chain Sequence
TELTLKPGTLTLAQLRAIHAAPVRLQLDASAAPAIDASVACVEQIIAEDRTAYGINTGFGLLASTRIASHDLENLQRSLVLSHAAGIGAPLDDDLVRLIMVLKINSLSRGFSGIRRKVIDALIALVNAEVYPHIPLKGSVGDLAPLAHMSLVLLGEGKARYKGQWLSATEALAVAGLEPLTLAAKEGLALLNGTQASTAYALRGLFYAEDLYAAAIACGGLSVEAVLGSRSPFDARIHEARGQRGQIDTAACFRDLLGDSSEVSLSHKNADKVQDPYSLRCQPQVMGACLTQLRQAAEVLGIEANAVSDNPLVFAAEGDVISGGNFHAEPVAMAADNLALAIAEIGSLSERRISLMMDKHMSQLPPFLVENGGVNSGFMIAQVTAAALASENKALSHPHSVDSLPTSANQEDHVSMAPAAGKRLWEMAENTRGVLAIEWLGACQGLDLRKGLKTSAKLEKARQALRSEVAHYDRDRFFAPDIEKAVELLAKGSLTGLLPAGVLPSL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of Two Histidine Ammonia-Lyase Modifications and Implications for the Catalytic Mechanism
pubmed doi rcsb
molecule tags Lyase
source organism Pseudomonas putida
molecule keywords HISTIDINE AMMONIA-LYASE
total genus 202
structure length 506
sequence length 507
ec nomenclature ec 4.3.1.3: Histidine ammonia-lyase.
pdb deposition date 2001-08-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1gkmA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1gkmA02
4APAA 3R6VA 1AUWA 1YISA 2RJRA 5EYVA 1GKJA 4EEIA 1DOFA 3CZOA 1TJWA 1FUPA 4NLEA 3NO9A 2J91A 2YIIA 2PTRA 3R6QA 2E9FA 2PTQA 3NZ4A 1Y2MA 4BAAA 3RD8A 4ADLA 1FUOA 1HY1A 1FUQA 1B8FA 3OCEA 1U16A 1I0AA 2PFMA 4NSLA 4FFXA 2NYNA 4C5UA 1RE5A 1GKMA 1YFMA 1HY0A 2O78A 3KDYA 3OCFA 3C8TA 3BHGA 1YFEA 4V2QA 2OHYA 1DCNA 4MX2A 1Q5NA 2VD6A 1K7WA 3R6YA 1FURA 2PTSA 4EFCA 1T6PA 5F92A 1GK3A 2O7EA 1U15A 4V2RA 4ADMA 4C6GA 1T6JA 5F91A 1JSWA 2O7BA 1W27A 5EYTA 2O6YA 3GTDA 3E04A 1KQ7A 1TJUA 4HGVA 1TJ7A 2O7FA 3KDZA 4APBA 2RJSA 5HW2A 2O7DA 4C5RA 2NYFA 4C5SA 4BABA 3GZHA 1GK2A 1C3CA 2X75A 1C3UA 1K62A 4CQ5A 5D6BA 3RRPA 2QGAB 2QVEA 1EB4A 1TJVA 3QBPA 3TV2A 2HVGA 2FUSA 3UNVA 1J3UA 1XWOA 4FLCA 1VDKA
chains in the Genus database with same CATH superfamily
4APAA 3R6VA 2FENA 1AUWA 1YISA 2RJRA 5EYVA 1GKJA 2VL7A 4EEIA 1DOFA 3CZOA 1TJWA 1FUPA 4NLEA 3NO9A 2J91A 4WNLA 1XMDA 2YIIA 2FELA 2E9FA 2PTRA 3R6QA 3CRVA 2PTQA 3NZ4A 1Y2MA 4BAAA 3RD8A 4ADLA 1FUOA 1XMCA 1HY1A 1FUQA 1B8FA 4A15A 3OCEA 1U16A 1I0AA 2PFMA 4NSLA 4FFXA 2NYNA 4C5UA 1RE5A 1GKMA 1YFMA 1HY0A 2O78A 3KDYA 3OCFA 3C8TA 3BHGA 1YFEA 4V2QA 2OHYA 1DCNA 4MX2A 1Q5NA 2VD6A 1XL7A 1XLYA 1K7WA 3R6YA 1FURA 5H8WA 2PTSA 4EFCA 1T6PA 5F92A 1GK3A 2O7EA 1U15A 4V2RA 4ADMA 2VSFA 4C6GA 1T6JA 5F91A 1JSWA 2O7BA 1W27A 5EYTA 2O6YA 3GTDA 3E04A 1KQ7A 1TJUA 4HGVA 1TJ7A 2O7FA 3CRW1 3KDZA 4APBA 2RJSA 5HW2A 2O7DA 4C5RA 2NYFA 4C5SA 4BABA 3GZHA 1GK2A 1C3CA 2X75A 1C3UA 5M0JA 1K62A 1XL8A 4CQ5A 5D6BA 3RRPA 5M0IA 2QGAB 2QVEA 1EB4A 1TJVA 3QBPA 3TV2A 2HVGA 2FUSA 3UNVA 1J3UA 1XWOA 4FLCA 1VDKA
chains in the Genus database with same CATH topology
4APAA 3R6VA 1AUWA 1YISA 2RJRA 5EYVA 1GKJA 4EEIA 1DOFA 3CZOA 1TJWA 1FUPA 4NLEA 3NO9A 2J91A 2YIIA 2PTRA 3R6QA 2E9FA 2PTQA 3NZ4A 1Y2MA 4BAAA 3RD8A 4ADLA 1FUOA 1HY1A 1FUQA 1B8FA 3OCEA 1U16A 1I0AA 2PFMA 4NSLA 4FFXA 2NYNA 4C5UA 1RE5A 1GKMA 1YFMA 1HY0A 2O78A 3KDYA 3OCFA 3C8TA 3BHGA 1YFEA 4V2QA 2OHYA 1DCNA 4MX2A 1Q5NA 2VD6A 1K7WA 3R6YA 1FURA 2PTSA 4EFCA 1T6PA 5F92A 1GK3A 2O7EA 1U15A 4V2RA 4ADMA 4C6GA 1T6JA 5F91A 1JSWA 2O7BA 1W27A 5EYTA 2O6YA 3GTDA 3E04A 1KQ7A 1TJUA 4HGVA 1TJ7A 2O7FA 3KDZA 4APBA 2RJSA 5HW2A 2O7DA 4C5RA 2NYFA 4C5SA 4BABA 3GZHA 1GK2A 1C3CA 2X75A 1C3UA 1K62A 4CQ5A 5D6BA 3RRPA 2QGAB 2QVEA 1EB4A 1TJVA 3QBPA 3TV2A 2HVGA 2FUSA 3UNVA 1J3UA 1XWOA 4FLCA 1VDKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4APA A;  3R6V A;  1AUW A;  1YIS A;  2RJR A;  5EYV A;  1GKJ A;  4EEI A;  1DOF A;  3CZO A;  1TJW A;  1FUP A;  4NLE A;  3NO9 A;  2J91 A;  2YII A;  2PTR A;  3R6Q A;  2E9F A;  2PTQ A;  3NZ4 A;  1Y2M A;  4BAA A;  3RD8 A;  4ADL A;  1FUO A;  1HY1 A;  1FUQ A;  1B8F A;  3OCE A;  1U16 A;  1I0A A;  2PFM A;  4NSL A;  4FFX A;  2NYN A;  4C5U A;  1RE5 A;  1GKM A;  1YFM A;  1HY0 A;  2O78 A;  3KDY A;  3OCF A;  3C8T A;  3BHG A;  1YFE A;  4V2Q A;  2OHY A;  1DCN A;  4MX2 A;  1Q5N A;  2VD6 A;  1K7W A;  3R6Y A;  1FUR A;  2PTS A;  4EFC A;  1T6P A;  5F92 A;  1GK3 A;  2O7E A;  1U15 A;  4V2R A;  4ADM A;  4C6G A;  1T6J A;  5F91 A;  1JSW A;  2O7B A;  1W27 A;  5EYT A;  2O6Y A;  3GTD A;  3E04 A;  1KQ7 A;  1TJU A;  4HGV A;  1TJ7 A;  2O7F A;  3KDZ A;  4APB A;  2RJS A;  5HW2 A;  2O7D A;  4C5R A;  2NYF A;  4C5S A;  4BAB A;  3GZH A;  1GK2 A;  1C3C A;  2X75 A;  1C3U A;  1K62 A;  4CQ5 A;  5D6B A;  3RRP A;  2QGA B;  2QVE A;  1EB4 A;  1TJV A;  3QBP A;  3TV2 A;  2HVG A;  2FUS A;  3UNV A;  1J3U A;  1XWO A;  4FLC A;  1VDK A; 
#chains in the Genus database with same CATH topology
 4APA A;  3R6V A;  2FEN A;  1AUW A;  1YIS A;  2RJR A;  5EYV A;  1GKJ A;  2VL7 A;  4EEI A;  1DOF A;  3CZO A;  1TJW A;  1FUP A;  4NLE A;  3NO9 A;  2J91 A;  4WNL A;  1XMD A;  2YII A;  2FEL A;  2E9F A;  2PTR A;  3R6Q A;  3CRV A;  2PTQ A;  3NZ4 A;  1Y2M A;  4BAA A;  3RD8 A;  4ADL A;  1FUO A;  1XMC A;  1HY1 A;  1FUQ A;  1B8F A;  4A15 A;  3OCE A;  1U16 A;  1I0A A;  2PFM A;  4NSL A;  4FFX A;  2NYN A;  4C5U A;  1RE5 A;  1GKM A;  1YFM A;  1HY0 A;  2O78 A;  3KDY A;  3OCF A;  3C8T A;  3BHG A;  1YFE A;  4V2Q A;  2OHY A;  1DCN A;  4MX2 A;  1Q5N A;  2VD6 A;  1XL7 A;  1XLY A;  1K7W A;  3R6Y A;  1FUR A;  5H8W A;  2PTS A;  4EFC A;  1T6P A;  5F92 A;  1GK3 A;  2O7E A;  1U15 A;  4V2R A;  4ADM A;  2VSF A;  4C6G A;  1T6J A;  5F91 A;  1JSW A;  2O7B A;  1W27 A;  5EYT A;  2O6Y A;  3GTD A;  3E04 A;  1KQ7 A;  1TJU A;  4HGV A;  1TJ7 A;  2O7F A;  3CRW 1;  3KDZ A;  4APB A;  2RJS A;  5HW2 A;  2O7D A;  4C5R A;  2NYF A;  4C5S A;  4BAB A;  3GZH A;  1GK2 A;  1C3C A;  2X75 A;  1C3U A;  5M0J A;  1K62 A;  1XL8 A;  4CQ5 A;  5D6B A;  3RRP A;  5M0I A;  2QGA B;  2QVE A;  1EB4 A;  1TJV A;  3QBP A;  3TV2 A;  2HVG A;  2FUS A;  3UNV A;  1J3U A;  1XWO A;  4FLC A;  1VDK A; 
#chains in the Genus database with same CATH homology
 4APA A;  3R6V A;  1AUW A;  1YIS A;  2RJR A;  5EYV A;  1GKJ A;  4EEI A;  1DOF A;  3CZO A;  1TJW A;  1FUP A;  4NLE A;  3NO9 A;  2J91 A;  2YII A;  2PTR A;  3R6Q A;  2E9F A;  2PTQ A;  3NZ4 A;  1Y2M A;  4BAA A;  3RD8 A;  4ADL A;  1FUO A;  1HY1 A;  1FUQ A;  1B8F A;  3OCE A;  1U16 A;  1I0A A;  2PFM A;  4NSL A;  4FFX A;  2NYN A;  4C5U A;  1RE5 A;  1GKM A;  1YFM A;  1HY0 A;  2O78 A;  3KDY A;  3OCF A;  3C8T A;  3BHG A;  1YFE A;  4V2Q A;  2OHY A;  1DCN A;  4MX2 A;  1Q5N A;  2VD6 A;  1K7W A;  3R6Y A;  1FUR A;  2PTS A;  4EFC A;  1T6P A;  5F92 A;  1GK3 A;  2O7E A;  1U15 A;  4V2R A;  4ADM A;  4C6G A;  1T6J A;  5F91 A;  1JSW A;  2O7B A;  1W27 A;  5EYT A;  2O6Y A;  3GTD A;  3E04 A;  1KQ7 A;  1TJU A;  4HGV A;  1TJ7 A;  2O7F A;  3KDZ A;  4APB A;  2RJS A;  5HW2 A;  2O7D A;  4C5R A;  2NYF A;  4C5S A;  4BAB A;  3GZH A;  1GK2 A;  1C3C A;  2X75 A;  1C3U A;  1K62 A;  4CQ5 A;  5D6B A;  3RRP A;  2QGA B;  2QVE A;  1EB4 A;  1TJV A;  3QBP A;  3TV2 A;  2HVG A;  2FUS A;  3UNV A;  1J3U A;  1XWO A;  4FLC A;  1VDK A; 
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