1FURA

Fumarase mutant h188n with bound substrate l-malate at putative activator site
Total Genus 168
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
168
sequence length
456
structure length
456
Chain Sequence
VRSEKDSMGAIDVPADKLWGAQTQRSLEHFRISTEKMPTSLIHALALTKRAAAKVNEDLGLLSEEKASAIRQAADEVLAGQHDDEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGVRGMERKVHPNDDVNKSQSSNDVFPTAMHVAALLALRKQLIPQLKTLTQTLNEKSRAFADIVKIGRTNLQDATPLTLGQEISGWVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYARRVADELAVITCAPFVTAPNKFEALATCDALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEISIPENEPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHNFLQSVRLLADGMESFNKHCAVGIEPNRERINQLLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAALALGYLSEAEFDSWVRPEQM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolyase
molecule keywords FUMARASE C
publication title Mutations of fumarase that distinguish between the active site and a nearby dicarboxylic acid binding site.
pubmed rcsb
source organism Escherichia coli
total genus 168
structure length 456
sequence length 456
chains with identical sequence B
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 1997-01-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 1furA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1furA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1furA02
2PTQA 2RJSA 1C3CA 1FUOA 5EYVA 1J3UA 4EFCA 2YIIA 4NSLA 1FURA 3KDZA 1I0AA 2FUSA 1HY1A 1TJUA 2O78A 3RRPA 1KQ7A 4CQ5A 3RD8A 1FUQA 1FUPA 5EYTA 3R6QA 1GK2A 2PFMA 2O6YA 4V2RA 4C5SA 4APBA 4ADMA 4NLEA 3NO9A 2QVEA 2X75A 4FFXA 3GZHA 4BAAA 1GK3A 2PTSA 3E04A 4ADLA 1W27A 1AUWA 2HVGA 1TJWA 2O7EA 1VDKA 2E9FA 2O7FA 4APAA 1Y2MA 2VD6A 3BHGA 5D6BA 1U16A 1HY0A 2QGAB 1TJ7A 3CZOA 2J91A 2O7DA 3QBPA 4C5RA 1XWOA 1GKJA 1K62A 4EEIA 4C5UA 1JSWA 2NYNA 2O7BA 1DOFA 3OCFA 1YFMA 2PTRA 1YFEA 4FLCA 2RJRA 1TJVA 3R6VA 3C8TA 1RE5A 3UNVA 2OHYA 3NZ4A 1C3UA 3KDYA 1YISA 1DCNA 4MX2A 1T6PA 3GTDA 1EB4A 4BABA 3R6YA 4C6GA 1Q5NA 5F91A 1GKMA 3OCEA 5F92A 4V2QA 4HGVA 1U15A 1T6JA 1K7WA 2NYFA 1B8FA 3TV2A 5HW2A
chains in the Genus database with same CATH superfamily
2PTQA 2RJSA 1C3CA 1FUOA 5EYVA 2JAWA 1MH9A 1J3UA 4EFCA 2YIIA 2VL7A 1U0LA 4NSLA 1FURA 3KDZA 4A15A 1I0AA 5H8WA 1XL7A 4NFLA 2FUSA 1HY1A 1TJUA 1IW7D 2O78A 3RRPA 1KQ7A 4CQ5A 3CRW1 2D27A 3CRVA 3RD8A 1FUQA 1FUPA 1Z4MA 5EYTA 3R6QA 1GK2A 2PFMA 2O6YA 1Z4QA 1XL8A 4V2RA 4C5SA 4APBA 4ADMA 4NLEA 3NO9A 2QVEA 2X75A 4FFXA 3GZHA 4BAAA 1GK3A 4WNLA 2PTSA 3E04A 3CI0K 4ADLA 1W27A 1AUWA 2HVGA 1TJWA 2RCNA 1XLYA 2O7EA 1Q92A 1VDKA 2E9FA 2O7FA 1Z4LA 4APAA 1Y2MA 2VD6A 2FENA 3BHGA 5D6BA 2I7DA 1U16A 1HY0A 4IQJM 2JAOA 2QGAB 4MUMA 1TJ7A 3CZOA 2J91A 3F4SA 3U19A 4YIKA 3QBPA 2O7DA 4C5RA 1XWOA 1GKJA 2VSFA 1K62A 4EEIA 4C5UA 1Z4PX 1JSWA 2NYNA 2O7BA 1Z4JA 1DOFA 3OCFA 1YFMA 3BWVA 2PTRA 5M0IA 1YFEA 2FELA 4FLCA 1XMCA 1T9HA 3U13A 2RJRA 1TJVA 3R6VA 3C8TA 1XMDA 1RE5A 3UNVA 4E88A 2OHYA 3NZ4A 1C3UA 3KDYA 1YISA 1DCNA 4MX2A 1Q91A 2YV5A 3GTDA 1EB4A 1T6PA 4BABA 2D28C 2JARA 3R6YA 3F4RA 4C6GA 1Z4IA 2JAUA 3F4TA 1Q5NA 5F91A 4L6AA 1GKMA 5M0JA 3OCEA 5F92A 1Z4KA 4HGVA 1U15A 4V2QA 1T6JA 1K7WA 2NYFA 4YIHA 1B8FA 4L6CA 3TV2A 5HW2A 4L57A 4MWOA
chains in the Genus database with same CATH topology
2PTQA 2RJSA 1C3CA 1FUOA 5EYVA 1J3UA 4EFCA 2YIIA 4NSLA 1FURA 3KDZA 1I0AA 2FUSA 1HY1A 1TJUA 2O78A 3RRPA 1KQ7A 4CQ5A 3RD8A 1FUQA 1FUPA 5EYTA 3R6QA 1GK2A 2PFMA 2O6YA 4V2RA 4C5SA 4APBA 4ADMA 4NLEA 3NO9A 2QVEA 2X75A 4FFXA 3GZHA 4BAAA 1GK3A 2PTSA 3E04A 4ADLA 1W27A 1AUWA 2HVGA 1TJWA 2O7EA 1VDKA 2E9FA 2O7FA 4APAA 1Y2MA 2VD6A 3BHGA 5D6BA 1U16A 1HY0A 2QGAB 1TJ7A 3CZOA 2J91A 2O7DA 3QBPA 4C5RA 1XWOA 1GKJA 1K62A 4EEIA 4C5UA 1JSWA 2NYNA 2O7BA 1DOFA 3OCFA 1YFMA 2PTRA 1YFEA 4FLCA 2RJRA 1TJVA 3R6VA 3C8TA 1RE5A 3UNVA 2OHYA 3NZ4A 1C3UA 3KDYA 1YISA 1DCNA 4MX2A 1T6PA 3GTDA 1EB4A 4BABA 3R6YA 4C6GA 1Q5NA 5F91A 1GKMA 3OCEA 5F92A 4V2QA 4HGVA 1U15A 1T6JA 1K7WA 2NYFA 1B8FA 3TV2A 5HW2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PTQ A;  2RJS A;  1C3C A;  1FUO A;  5EYV A;  1J3U A;  4EFC A;  2YII A;  4NSL A;  1FUR A;  3KDZ A;  1I0A A;  2FUS A;  1HY1 A;  1TJU A;  2O78 A;  3RRP A;  1KQ7 A;  4CQ5 A;  3RD8 A;  1FUQ A;  1FUP A;  5EYT A;  3R6Q A;  1GK2 A;  2PFM A;  2O6Y A;  4V2R A;  4C5S A;  4APB A;  4ADM A;  4NLE A;  3NO9 A;  2QVE A;  2X75 A;  4FFX A;  3GZH A;  4BAA A;  1GK3 A;  2PTS A;  3E04 A;  4ADL A;  1W27 A;  1AUW A;  2HVG A;  1TJW A;  2O7E A;  1VDK A;  2E9F A;  2O7F A;  4APA A;  1Y2M A;  2VD6 A;  3BHG A;  5D6B A;  1U16 A;  1HY0 A;  2QGA B;  1TJ7 A;  3CZO A;  2J91 A;  2O7D A;  3QBP A;  4C5R A;  1XWO A;  1GKJ A;  1K62 A;  4EEI A;  4C5U A;  1JSW A;  2NYN A;  2O7B A;  1DOF A;  3OCF A;  1YFM A;  2PTR A;  1YFE A;  4FLC A;  2RJR A;  1TJV A;  3R6V A;  3C8T A;  1RE5 A;  3UNV A;  2OHY A;  3NZ4 A;  1C3U A;  3KDY A;  1YIS A;  1DCN A;  4MX2 A;  1T6P A;  3GTD A;  1EB4 A;  4BAB A;  3R6Y A;  4C6G A;  1Q5N A;  5F91 A;  1GKM A;  3OCE A;  5F92 A;  4V2Q A;  4HGV A;  1U15 A;  1T6J A;  1K7W A;  2NYF A;  1B8F A;  3TV2 A;  5HW2 A; 
#chains in the Genus database with same CATH topology
 2PTQ A;  2RJS A;  1C3C A;  1FUO A;  5EYV A;  2JAW A;  1MH9 A;  1J3U A;  4EFC A;  2YII A;  2VL7 A;  1U0L A;  4NSL A;  1FUR A;  3KDZ A;  4A15 A;  1I0A A;  5H8W A;  1XL7 A;  4NFL A;  2FUS A;  1HY1 A;  1TJU A;  1IW7 D;  2O78 A;  3RRP A;  1KQ7 A;  4CQ5 A;  3CRW 1;  2D27 A;  3CRV A;  3RD8 A;  1FUQ A;  1FUP A;  1Z4M A;  5EYT A;  3R6Q A;  1GK2 A;  2PFM A;  2O6Y A;  1Z4Q A;  1XL8 A;  4V2R A;  4C5S A;  4APB A;  4ADM A;  4NLE A;  3NO9 A;  2QVE A;  2X75 A;  4FFX A;  3GZH A;  4BAA A;  1GK3 A;  4WNL A;  2PTS A;  3E04 A;  3CI0 K;  4ADL A;  1W27 A;  1AUW A;  2HVG A;  1TJW A;  2RCN A;  1XLY A;  2O7E A;  1Q92 A;  1VDK A;  2E9F A;  2O7F A;  1Z4L A;  4APA A;  1Y2M A;  2VD6 A;  2FEN A;  3BHG A;  5D6B A;  2I7D A;  1U16 A;  1HY0 A;  4IQJ M;  2JAO A;  2QGA B;  4MUM A;  1TJ7 A;  3CZO A;  2J91 A;  3F4S A;  3U19 A;  4YIK A;  3QBP A;  2O7D A;  4C5R A;  1XWO A;  1GKJ A;  2VSF A;  1K62 A;  4EEI A;  4C5U A;  1Z4P X;  1JSW A;  2NYN A;  2O7B A;  1Z4J A;  1DOF A;  3OCF A;  1YFM A;  3BWV A;  2PTR A;  5M0I A;  1YFE A;  2FEL A;  4FLC A;  1XMC A;  1T9H A;  3U13 A;  2RJR A;  1TJV A;  3R6V A;  3C8T A;  1XMD A;  1RE5 A;  3UNV A;  4E88 A;  2OHY A;  3NZ4 A;  1C3U A;  3KDY A;  1YIS A;  1DCN A;  4MX2 A;  1Q91 A;  2YV5 A;  3GTD A;  1EB4 A;  1T6P A;  4BAB A;  2D28 C;  2JAR A;  3R6Y A;  3F4R A;  4C6G A;  1Z4I A;  2JAU A;  3F4T A;  1Q5N A;  5F91 A;  4L6A A;  1GKM A;  5M0J A;  3OCE A;  5F92 A;  1Z4K A;  4HGV A;  1U15 A;  4V2Q A;  1T6J A;  1K7W A;  2NYF A;  4YIH A;  1B8F A;  4L6C A;  3TV2 A;  5HW2 A;  4L57 A;  4MWO A; 
#chains in the Genus database with same CATH homology
 2PTQ A;  2RJS A;  1C3C A;  1FUO A;  5EYV A;  1J3U A;  4EFC A;  2YII A;  4NSL A;  1FUR A;  3KDZ A;  1I0A A;  2FUS A;  1HY1 A;  1TJU A;  2O78 A;  3RRP A;  1KQ7 A;  4CQ5 A;  3RD8 A;  1FUQ A;  1FUP A;  5EYT A;  3R6Q A;  1GK2 A;  2PFM A;  2O6Y A;  4V2R A;  4C5S A;  4APB A;  4ADM A;  4NLE A;  3NO9 A;  2QVE A;  2X75 A;  4FFX A;  3GZH A;  4BAA A;  1GK3 A;  2PTS A;  3E04 A;  4ADL A;  1W27 A;  1AUW A;  2HVG A;  1TJW A;  2O7E A;  1VDK A;  2E9F A;  2O7F A;  4APA A;  1Y2M A;  2VD6 A;  3BHG A;  5D6B A;  1U16 A;  1HY0 A;  2QGA B;  1TJ7 A;  3CZO A;  2J91 A;  2O7D A;  3QBP A;  4C5R A;  1XWO A;  1GKJ A;  1K62 A;  4EEI A;  4C5U A;  1JSW A;  2NYN A;  2O7B A;  1DOF A;  3OCF A;  1YFM A;  2PTR A;  1YFE A;  4FLC A;  2RJR A;  1TJV A;  3R6V A;  3C8T A;  1RE5 A;  3UNV A;  2OHY A;  3NZ4 A;  1C3U A;  3KDY A;  1YIS A;  1DCN A;  4MX2 A;  1T6P A;  3GTD A;  1EB4 A;  4BAB A;  3R6Y A;  4C6G A;  1Q5N A;  5F91 A;  1GKM A;  3OCE A;  5F92 A;  4V2Q A;  4HGV A;  1U15 A;  1T6J A;  1K7W A;  2NYF A;  1B8F A;  3TV2 A;  5HW2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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