1FURA

Fumarase mutant h188n with bound substrate l-malate at putative activator site
Total Genus 168
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
168
sequence length
456
structure length
456
Chain Sequence
VRSEKDSMGAIDVPADKLWGAQTQRSLEHFRISTEKMPTSLIHALALTKRAAAKVNEDLGLLSEEKASAIRQAADEVLAGQHDDEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGVRGMERKVHPNDDVNKSQSSNDVFPTAMHVAALLALRKQLIPQLKTLTQTLNEKSRAFADIVKIGRTNLQDATPLTLGQEISGWVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYARRVADELAVITCAPFVTAPNKFEALATCDALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEISIPENEPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHNFLQSVRLLADGMESFNKHCAVGIEPNRERINQLLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAALALGYLSEAEFDSWVRPEQM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mutations of fumarase that distinguish between the active site and a nearby dicarboxylic acid binding site.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolyase
molecule keywords FUMARASE C
total genus 168
structure length 456
sequence length 456
chains with identical sequence B
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 1997-01-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 1furA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1furA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1furA02
1DCNA 4EFCA 3CZOA 5EYVA 1K62A 4NSLA 4V2RA 2VD6A 1GKMA 1K7WA 2PTSA 4MX2A 4EEIA 1T6JA 2O7FA 3OCEA 1FUQA 2QVEA 5D6BA 3RD8A 4ADMA 2O6YA 1FURA 1YFEA 1GK2A 3C8TA 3R6YA 5HW2A 1JSWA 3TV2A 2O7EA 1FUPA 3NO9A 2RJSA 1TJUA 3KDZA 4V2QA 1HY0A 1GKJA 1DOFA 2FUSA 4C5SA 2NYNA 2O7DA 1C3CA 4APAA 2O78A 4BAAA 4C5RA 1Q5NA 1W27A 1TJVA 1GK3A 4HGVA 4FLCA 2RJRA 3R6QA 1YISA 2OHYA 1C3UA 2NYFA 3GTDA 1KQ7A 1U15A 1RE5A 4FFXA 3GZHA 4NLEA 1XWOA 1YFMA 2HVGA 2O7BA 1T6PA 5F91A 1TJWA 3R6VA 4C5UA 3QBPA 3OCFA 3E04A 1I0AA 2PTRA 1AUWA 1VDKA 3RRPA 3UNVA 1Y2MA 1HY1A 2QGAB 2E9FA 1U16A 4C6GA 4CQ5A 1FUOA 4BABA 2PTQA 2YIIA 2PFMA 1TJ7A 3NZ4A 1B8FA 1EB4A 4ADLA 5F92A 5EYTA 3KDYA 1J3UA 2J91A 4APBA 2X75A 3BHGA
chains in the Genus database with same CATH superfamily
1DCNA 4EFCA 4MWOA 2YV5A 1T9HA 3CZOA 3U19A 5EYVA 5M0IA 1U0LA 1K62A 4MUMA 4NSLA 4V2RA 2VD6A 1GKMA 3U13A 1Z4LA 1K7WA 2PTSA 4MX2A 4YIHA 4EEIA 1T6JA 2O7FA 3OCEA 1FUQA 2I7DA 2D28C 5D6BA 2QVEA 3RD8A 4ADMA 2O6YA 1XMCA 1Z4IA 2JAUA 2D27A 1FURA 5M0JA 3F4RA 1YFEA 1GK2A 3C8TA 3R6YA 2FENA 5HW2A 1JSWA 1IW7D 3TV2A 1XL7A 2O7EA 1Z4MA 1FUPA 3NO9A 2RJSA 2JARA 1TJUA 4A15A 4NFLA 3KDZA 4V2QA 1HY0A 1GKJA 1DOFA 2FUSA 4IQJM 4C5SA 2NYNA 2O7DA 1XLYA 3F4SA 2RCNA 4L6CA 3BWVA 1C3CA 4APAA 2O78A 4BAAA 2JAWA 4C5RA 1Q5NA 1MH9A 1W27A 1TJVA 1GK3A 4HGVA 4FLCA 2JAOA 2RJRA 3R6QA 1YISA 2OHYA 1C3UA 2NYFA 3GTDA 1Q91A 2VSFA 3CRVA 1KQ7A 1U15A 1RE5A 4FFXA 3GZHA 4NLEA 1XWOA 1YFMA 2HVGA 1T6PA 2O7BA 5F91A 1TJWA 3R6VA 4C5UA 1XMDA 3QBPA 3OCFA 1XL8A 3E04A 1I0AA 1Q92A 2PTRA 1Z4KA 1AUWA 1VDKA 3RRPA 4L6AA 3F4TA 3UNVA 1Y2MA 5H8WA 1HY1A 2QGAB 2E9FA 1U16A 4C6GA 4WNLA 4CQ5A 1FUOA 3CI0K 4BABA 3CRW1 2PTQA 1Z4QA 4L57A 2YIIA 2PFMA 1TJ7A 3NZ4A 1B8FA 1EB4A 4ADLA 5F92A 2VL7A 5EYTA 2FELA 4YIKA 3KDYA 1J3UA 1Z4JA 4E88A 2J91A 4APBA 2X75A 3BHGA 1Z4PX
chains in the Genus database with same CATH topology
1DCNA 4EFCA 3CZOA 5EYVA 1K62A 4NSLA 4V2RA 2VD6A 1GKMA 1K7WA 2PTSA 4MX2A 4EEIA 1T6JA 2O7FA 3OCEA 1FUQA 2QVEA 5D6BA 3RD8A 4ADMA 2O6YA 1FURA 1YFEA 1GK2A 3C8TA 3R6YA 5HW2A 1JSWA 3TV2A 2O7EA 1FUPA 3NO9A 2RJSA 1TJUA 3KDZA 4V2QA 1HY0A 1GKJA 1DOFA 2FUSA 4C5SA 2NYNA 2O7DA 1C3CA 4APAA 2O78A 4BAAA 4C5RA 1Q5NA 1W27A 1TJVA 1GK3A 4HGVA 4FLCA 2RJRA 3R6QA 1YISA 2OHYA 1C3UA 2NYFA 3GTDA 1KQ7A 1U15A 1RE5A 4FFXA 3GZHA 4NLEA 1XWOA 1YFMA 2HVGA 2O7BA 1T6PA 5F91A 1TJWA 3R6VA 4C5UA 3QBPA 3OCFA 3E04A 1I0AA 2PTRA 1AUWA 1VDKA 3RRPA 3UNVA 1Y2MA 1HY1A 2QGAB 2E9FA 1U16A 4C6GA 4CQ5A 1FUOA 4BABA 2PTQA 2YIIA 2PFMA 1TJ7A 3NZ4A 1B8FA 1EB4A 4ADLA 5F92A 5EYTA 3KDYA 1J3UA 2J91A 4APBA 2X75A 3BHGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DCN A;  4EFC A;  3CZO A;  5EYV A;  1K62 A;  4NSL A;  4V2R A;  2VD6 A;  1GKM A;  1K7W A;  2PTS A;  4MX2 A;  4EEI A;  1T6J A;  2O7F A;  3OCE A;  1FUQ A;  2QVE A;  5D6B A;  3RD8 A;  4ADM A;  2O6Y A;  1FUR A;  1YFE A;  1GK2 A;  3C8T A;  3R6Y A;  5HW2 A;  1JSW A;  3TV2 A;  2O7E A;  1FUP A;  3NO9 A;  2RJS A;  1TJU A;  3KDZ A;  4V2Q A;  1HY0 A;  1GKJ A;  1DOF A;  2FUS A;  4C5S A;  2NYN A;  2O7D A;  1C3C A;  4APA A;  2O78 A;  4BAA A;  4C5R A;  1Q5N A;  1W27 A;  1TJV A;  1GK3 A;  4HGV A;  4FLC A;  2RJR A;  3R6Q A;  1YIS A;  2OHY A;  1C3U A;  2NYF A;  3GTD A;  1KQ7 A;  1U15 A;  1RE5 A;  4FFX A;  3GZH A;  4NLE A;  1XWO A;  1YFM A;  2HVG A;  2O7B A;  1T6P A;  5F91 A;  1TJW A;  3R6V A;  4C5U A;  3QBP A;  3OCF A;  3E04 A;  1I0A A;  2PTR A;  1AUW A;  1VDK A;  3RRP A;  3UNV A;  1Y2M A;  1HY1 A;  2QGA B;  2E9F A;  1U16 A;  4C6G A;  4CQ5 A;  1FUO A;  4BAB A;  2PTQ A;  2YII A;  2PFM A;  1TJ7 A;  3NZ4 A;  1B8F A;  1EB4 A;  4ADL A;  5F92 A;  5EYT A;  3KDY A;  1J3U A;  2J91 A;  4APB A;  2X75 A;  3BHG A; 
#chains in the Genus database with same CATH topology
 1DCN A;  4EFC A;  4MWO A;  2YV5 A;  1T9H A;  3CZO A;  3U19 A;  5EYV A;  5M0I A;  1U0L A;  1K62 A;  4MUM A;  4NSL A;  4V2R A;  2VD6 A;  1GKM A;  3U13 A;  1Z4L A;  1K7W A;  2PTS A;  4MX2 A;  4YIH A;  4EEI A;  1T6J A;  2O7F A;  3OCE A;  1FUQ A;  2I7D A;  2D28 C;  5D6B A;  2QVE A;  3RD8 A;  4ADM A;  2O6Y A;  1XMC A;  1Z4I A;  2JAU A;  2D27 A;  1FUR A;  5M0J A;  3F4R A;  1YFE A;  1GK2 A;  3C8T A;  3R6Y A;  2FEN A;  5HW2 A;  1JSW A;  1IW7 D;  3TV2 A;  1XL7 A;  2O7E A;  1Z4M A;  1FUP A;  3NO9 A;  2RJS A;  2JAR A;  1TJU A;  4A15 A;  4NFL A;  3KDZ A;  4V2Q A;  1HY0 A;  1GKJ A;  1DOF A;  2FUS A;  4IQJ M;  4C5S A;  2NYN A;  2O7D A;  1XLY A;  3F4S A;  2RCN A;  4L6C A;  3BWV A;  1C3C A;  4APA A;  2O78 A;  4BAA A;  2JAW A;  4C5R A;  1Q5N A;  1MH9 A;  1W27 A;  1TJV A;  1GK3 A;  4HGV A;  4FLC A;  2JAO A;  2RJR A;  3R6Q A;  1YIS A;  2OHY A;  1C3U A;  2NYF A;  3GTD A;  1Q91 A;  2VSF A;  3CRV A;  1KQ7 A;  1U15 A;  1RE5 A;  4FFX A;  3GZH A;  4NLE A;  1XWO A;  1YFM A;  2HVG A;  1T6P A;  2O7B A;  5F91 A;  1TJW A;  3R6V A;  4C5U A;  1XMD A;  3QBP A;  3OCF A;  1XL8 A;  3E04 A;  1I0A A;  1Q92 A;  2PTR A;  1Z4K A;  1AUW A;  1VDK A;  3RRP A;  4L6A A;  3F4T A;  3UNV A;  1Y2M A;  5H8W A;  1HY1 A;  2QGA B;  2E9F A;  1U16 A;  4C6G A;  4WNL A;  4CQ5 A;  1FUO A;  3CI0 K;  4BAB A;  3CRW 1;  2PTQ A;  1Z4Q A;  4L57 A;  2YII A;  2PFM A;  1TJ7 A;  3NZ4 A;  1B8F A;  1EB4 A;  4ADL A;  5F92 A;  2VL7 A;  5EYT A;  2FEL A;  4YIK A;  3KDY A;  1J3U A;  1Z4J A;  4E88 A;  2J91 A;  4APB A;  2X75 A;  3BHG A;  1Z4P X; 
#chains in the Genus database with same CATH homology
 1DCN A;  4EFC A;  3CZO A;  5EYV A;  1K62 A;  4NSL A;  4V2R A;  2VD6 A;  1GKM A;  1K7W A;  2PTS A;  4MX2 A;  4EEI A;  1T6J A;  2O7F A;  3OCE A;  1FUQ A;  2QVE A;  5D6B A;  3RD8 A;  4ADM A;  2O6Y A;  1FUR A;  1YFE A;  1GK2 A;  3C8T A;  3R6Y A;  5HW2 A;  1JSW A;  3TV2 A;  2O7E A;  1FUP A;  3NO9 A;  2RJS A;  1TJU A;  3KDZ A;  4V2Q A;  1HY0 A;  1GKJ A;  1DOF A;  2FUS A;  4C5S A;  2NYN A;  2O7D A;  1C3C A;  4APA A;  2O78 A;  4BAA A;  4C5R A;  1Q5N A;  1W27 A;  1TJV A;  1GK3 A;  4HGV A;  4FLC A;  2RJR A;  3R6Q A;  1YIS A;  2OHY A;  1C3U A;  2NYF A;  3GTD A;  1KQ7 A;  1U15 A;  1RE5 A;  4FFX A;  3GZH A;  4NLE A;  1XWO A;  1YFM A;  2HVG A;  2O7B A;  1T6P A;  5F91 A;  1TJW A;  3R6V A;  4C5U A;  3QBP A;  3OCF A;  3E04 A;  1I0A A;  2PTR A;  1AUW A;  1VDK A;  3RRP A;  3UNV A;  1Y2M A;  1HY1 A;  2QGA B;  2E9F A;  1U16 A;  4C6G A;  4CQ5 A;  1FUO A;  4BAB A;  2PTQ A;  2YII A;  2PFM A;  1TJ7 A;  3NZ4 A;  1B8F A;  1EB4 A;  4ADL A;  5F92 A;  5EYT A;  3KDY A;  1J3U A;  2J91 A;  4APB A;  2X75 A;  3BHG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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