1FURA

Fumarase mutant h188n with bound substrate l-malate at putative activator site
Total Genus 168
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
168
sequence length
456
structure length
456
Chain Sequence
VRSEKDSMGAIDVPADKLWGAQTQRSLEHFRISTEKMPTSLIHALALTKRAAAKVNEDLGLLSEEKASAIRQAADEVLAGQHDDEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGVRGMERKVHPNDDVNKSQSSNDVFPTAMHVAALLALRKQLIPQLKTLTQTLNEKSRAFADIVKIGRTNLQDATPLTLGQEISGWVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYARRVADELAVITCAPFVTAPNKFEALATCDALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEISIPENEPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHNFLQSVRLLADGMESFNKHCAVGIEPNRERINQLLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAALALGYLSEAEFDSWVRPEQM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords FUMARASE C
publication title Mutations of fumarase that distinguish between the active site and a nearby dicarboxylic acid binding site.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolyase
total genus 168
structure length 456
sequence length 456
chains with identical sequence B
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 1997-01-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 1furA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1furA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1furA02
1YISA 3OCEA 1EB4A 3KDZA 3BHGA 4APAA 2X75A 3OCFA 2OHYA 1GKMA 4C5RA 3NZ4A 4ADMA 1DOFA 2O7EA 1I0AA 1K7WA 1Y2MA 2O7FA 2O7DA 4FFXA 4MX2A 1FUQA 4C5SA 3RD8A 1YFMA 1Q5NA 1RE5A 3TV2A 4APBA 2PTQA 1GK2A 1GK3A 1U16A 3R6VA 2O78A 2PTSA 3RRPA 4BABA 3GTDA 3E04A 3KDYA 1YFEA 1HY1A 1TJVA 2E9FA 1XWOA 1T6PA 1W27A 1FUPA 1JSWA 4V2RA 1AUWA 4CQ5A 1FURA 2FUSA 1K62A 1VDKA 2YIIA 2O6YA 2RJSA 5EYTA 2RJRA 3C8TA 2O7BA 5F91A 2HVGA 1DCNA 1TJUA 1T6JA 4ADLA 3R6QA 4C5UA 1J3UA 3GZHA 4C6GA 1TJ7A 2QGAB 2PTRA 1U15A 5HW2A 5EYVA 4V2QA 2QVEA 4BAAA 1C3UA 5F92A 3UNVA 1FUOA 3QBPA 1HY0A 4NSLA 4EEIA 4HGVA 2PFMA 2J91A 3CZOA 4EFCA 2VD6A 1GKJA 1C3CA 1TJWA 1KQ7A 3NO9A 2NYFA 4NLEA 1B8FA 2NYNA 4FLCA 3R6YA 5D6BA
chains in the Genus database with same CATH superfamily
1YISA 3OCEA 3U13A 1EB4A 3KDZA 3BHGA 4APAA 2X75A 3F4TA 3OCFA 2OHYA 2FELA 1Z4MA 4L57A 1GKMA 4C5RA 2D28C 3CI0K 1XL7A 1MH9A 3NZ4A 1Z4QA 4ADMA 1DOFA 2O7EA 1I0AA 1K7WA 1Y2MA 4MUMA 2O7FA 2O7DA 4FFXA 4MX2A 1FUQA 1XL8A 4NFLA 2JAOA 2YV5A 4C5SA 1Z4PX 2RCNA 1YFMA 1Q5NA 3RD8A 1RE5A 3TV2A 4APBA 3BWVA 1Z4JA 4YIKA 2PTQA 1GK2A 1GK3A 1U16A 3R6VA 2O78A 4WNLA 2PTSA 3RRPA 4BABA 1Z4IA 3GTDA 3E04A 3KDYA 1YFEA 1HY1A 3CRVA 1TJVA 2E9FA 1XWOA 1T6PA 1W27A 1FUPA 1XMCA 4A15A 1JSWA 4V2RA 1AUWA 4CQ5A 1FURA 2VSFA 2FUSA 1K62A 2I7DA 1IW7D 2D27A 1VDKA 5M0IA 1U0LA 4YIHA 2YIIA 2O6YA 2VL7A 2FENA 2RJSA 3F4SA 5EYTA 2RJRA 3C8TA 2O7BA 5F91A 5H8WA 2HVGA 4L6AA 1DCNA 1XLYA 1TJUA 1T6JA 4ADLA 4L6CA 3R6QA 1J3UA 1XMDA 4C5UA 3GZHA 4C6GA 5M0JA 1TJ7A 4MWOA 2QGAB 2PTRA 1U15A 4IQJM 5HW2A 5EYVA 1Z4KA 4V2QA 2JAUA 1Z4LA 2QVEA 4BAAA 1C3UA 5F92A 3UNVA 1FUOA 3QBPA 1HY0A 4NSLA 3F4RA 4EEIA 4HGVA 2PFMA 2J91A 3CZOA 4EFCA 2VD6A 1GKJA 1C3CA 4E88A 1TJWA 1KQ7A 1Q92A 3NO9A 2NYFA 1Q91A 1T9HA 4NLEA 2JARA 1B8FA 2JAWA 2NYNA 4FLCA 3R6YA 3CRW1 5D6BA 3U19A
chains in the Genus database with same CATH topology
1YISA 3OCEA 1EB4A 3KDZA 3BHGA 4APAA 2X75A 3OCFA 2OHYA 1GKMA 4C5RA 3NZ4A 4ADMA 1DOFA 2O7EA 1I0AA 1K7WA 1Y2MA 2O7FA 2O7DA 4FFXA 4MX2A 1FUQA 4C5SA 3RD8A 1YFMA 1Q5NA 1RE5A 3TV2A 4APBA 2PTQA 1GK2A 1GK3A 1U16A 3R6VA 2O78A 2PTSA 3RRPA 4BABA 3GTDA 3E04A 3KDYA 1YFEA 1HY1A 1TJVA 2E9FA 1XWOA 1T6PA 1W27A 1FUPA 1JSWA 4V2RA 1AUWA 4CQ5A 1FURA 2FUSA 1K62A 1VDKA 2YIIA 2O6YA 2RJSA 5EYTA 2RJRA 3C8TA 2O7BA 5F91A 2HVGA 1DCNA 1TJUA 1T6JA 4ADLA 3R6QA 4C5UA 1J3UA 3GZHA 4C6GA 1TJ7A 2QGAB 2PTRA 1U15A 5HW2A 5EYVA 4V2QA 2QVEA 4BAAA 1C3UA 5F92A 3UNVA 1FUOA 3QBPA 1HY0A 4NSLA 4EEIA 4HGVA 2PFMA 2J91A 3CZOA 4EFCA 2VD6A 1GKJA 1C3CA 1TJWA 1KQ7A 3NO9A 2NYFA 4NLEA 1B8FA 2NYNA 4FLCA 3R6YA 5D6BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YIS A;  3OCE A;  1EB4 A;  3KDZ A;  3BHG A;  4APA A;  2X75 A;  3OCF A;  2OHY A;  1GKM A;  4C5R A;  3NZ4 A;  4ADM A;  1DOF A;  2O7E A;  1I0A A;  1K7W A;  1Y2M A;  2O7F A;  2O7D A;  4FFX A;  4MX2 A;  1FUQ A;  4C5S A;  3RD8 A;  1YFM A;  1Q5N A;  1RE5 A;  3TV2 A;  4APB A;  2PTQ A;  1GK2 A;  1GK3 A;  1U16 A;  3R6V A;  2O78 A;  2PTS A;  3RRP A;  4BAB A;  3GTD A;  3E04 A;  3KDY A;  1YFE A;  1HY1 A;  1TJV A;  2E9F A;  1XWO A;  1T6P A;  1W27 A;  1FUP A;  1JSW A;  4V2R A;  1AUW A;  4CQ5 A;  1FUR A;  2FUS A;  1K62 A;  1VDK A;  2YII A;  2O6Y A;  2RJS A;  5EYT A;  2RJR A;  3C8T A;  2O7B A;  5F91 A;  2HVG A;  1DCN A;  1TJU A;  1T6J A;  4ADL A;  3R6Q A;  4C5U A;  1J3U A;  3GZH A;  4C6G A;  1TJ7 A;  2QGA B;  2PTR A;  1U15 A;  5HW2 A;  5EYV A;  4V2Q A;  2QVE A;  4BAA A;  1C3U A;  5F92 A;  3UNV A;  1FUO A;  3QBP A;  1HY0 A;  4NSL A;  4EEI A;  4HGV A;  2PFM A;  2J91 A;  3CZO A;  4EFC A;  2VD6 A;  1GKJ A;  1C3C A;  1TJW A;  1KQ7 A;  3NO9 A;  2NYF A;  4NLE A;  1B8F A;  2NYN A;  4FLC A;  3R6Y A;  5D6B A; 
#chains in the Genus database with same CATH topology
 1YIS A;  3OCE A;  3U13 A;  1EB4 A;  3KDZ A;  3BHG A;  4APA A;  2X75 A;  3F4T A;  3OCF A;  2OHY A;  2FEL A;  1Z4M A;  4L57 A;  1GKM A;  4C5R A;  2D28 C;  3CI0 K;  1XL7 A;  1MH9 A;  3NZ4 A;  1Z4Q A;  4ADM A;  1DOF A;  2O7E A;  1I0A A;  1K7W A;  1Y2M A;  4MUM A;  2O7F A;  2O7D A;  4FFX A;  4MX2 A;  1FUQ A;  1XL8 A;  4NFL A;  2JAO A;  2YV5 A;  4C5S A;  1Z4P X;  2RCN A;  1YFM A;  1Q5N A;  3RD8 A;  1RE5 A;  3TV2 A;  4APB A;  3BWV A;  1Z4J A;  4YIK A;  2PTQ A;  1GK2 A;  1GK3 A;  1U16 A;  3R6V A;  2O78 A;  4WNL A;  2PTS A;  3RRP A;  4BAB A;  1Z4I A;  3GTD A;  3E04 A;  3KDY A;  1YFE A;  1HY1 A;  3CRV A;  1TJV A;  2E9F A;  1XWO A;  1T6P A;  1W27 A;  1FUP A;  1XMC A;  4A15 A;  1JSW A;  4V2R A;  1AUW A;  4CQ5 A;  1FUR A;  2VSF A;  2FUS A;  1K62 A;  2I7D A;  1IW7 D;  2D27 A;  1VDK A;  5M0I A;  1U0L A;  4YIH A;  2YII A;  2O6Y A;  2VL7 A;  2FEN A;  2RJS A;  3F4S A;  5EYT A;  2RJR A;  3C8T A;  2O7B A;  5F91 A;  5H8W A;  2HVG A;  4L6A A;  1DCN A;  1XLY A;  1TJU A;  1T6J A;  4ADL A;  4L6C A;  3R6Q A;  1J3U A;  1XMD A;  4C5U A;  3GZH A;  4C6G A;  5M0J A;  1TJ7 A;  4MWO A;  2QGA B;  2PTR A;  1U15 A;  4IQJ M;  5HW2 A;  5EYV A;  1Z4K A;  4V2Q A;  2JAU A;  1Z4L A;  2QVE A;  4BAA A;  1C3U A;  5F92 A;  3UNV A;  1FUO A;  3QBP A;  1HY0 A;  4NSL A;  3F4R A;  4EEI A;  4HGV A;  2PFM A;  2J91 A;  3CZO A;  4EFC A;  2VD6 A;  1GKJ A;  1C3C A;  4E88 A;  1TJW A;  1KQ7 A;  1Q92 A;  3NO9 A;  2NYF A;  1Q91 A;  1T9H A;  4NLE A;  2JAR A;  1B8F A;  2JAW A;  2NYN A;  4FLC A;  3R6Y A;  3CRW 1;  5D6B A;  3U19 A; 
#chains in the Genus database with same CATH homology
 1YIS A;  3OCE A;  1EB4 A;  3KDZ A;  3BHG A;  4APA A;  2X75 A;  3OCF A;  2OHY A;  1GKM A;  4C5R A;  3NZ4 A;  4ADM A;  1DOF A;  2O7E A;  1I0A A;  1K7W A;  1Y2M A;  2O7F A;  2O7D A;  4FFX A;  4MX2 A;  1FUQ A;  4C5S A;  3RD8 A;  1YFM A;  1Q5N A;  1RE5 A;  3TV2 A;  4APB A;  2PTQ A;  1GK2 A;  1GK3 A;  1U16 A;  3R6V A;  2O78 A;  2PTS A;  3RRP A;  4BAB A;  3GTD A;  3E04 A;  3KDY A;  1YFE A;  1HY1 A;  1TJV A;  2E9F A;  1XWO A;  1T6P A;  1W27 A;  1FUP A;  1JSW A;  4V2R A;  1AUW A;  4CQ5 A;  1FUR A;  2FUS A;  1K62 A;  1VDK A;  2YII A;  2O6Y A;  2RJS A;  5EYT A;  2RJR A;  3C8T A;  2O7B A;  5F91 A;  2HVG A;  1DCN A;  1TJU A;  1T6J A;  4ADL A;  3R6Q A;  4C5U A;  1J3U A;  3GZH A;  4C6G A;  1TJ7 A;  2QGA B;  2PTR A;  1U15 A;  5HW2 A;  5EYV A;  4V2Q A;  2QVE A;  4BAA A;  1C3U A;  5F92 A;  3UNV A;  1FUO A;  3QBP A;  1HY0 A;  4NSL A;  4EEI A;  4HGV A;  2PFM A;  2J91 A;  3CZO A;  4EFC A;  2VD6 A;  1GKJ A;  1C3C A;  1TJW A;  1KQ7 A;  3NO9 A;  2NYF A;  4NLE A;  1B8F A;  2NYN A;  4FLC A;  3R6Y A;  5D6B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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