1FURA

Fumarase mutant h188n with bound substrate l-malate at putative activator site
Total Genus 168
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
168
sequence length
456
structure length
456
Chain Sequence
VRSEKDSMGAIDVPADKLWGAQTQRSLEHFRISTEKMPTSLIHALALTKRAAAKVNEDLGLLSEEKASAIRQAADEVLAGQHDDEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGVRGMERKVHPNDDVNKSQSSNDVFPTAMHVAALLALRKQLIPQLKTLTQTLNEKSRAFADIVKIGRTNLQDATPLTLGQEISGWVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYARRVADELAVITCAPFVTAPNKFEALATCDALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEISIPENEPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHNFLQSVRLLADGMESFNKHCAVGIEPNRERINQLLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAALALGYLSEAEFDSWVRPEQM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mutations of fumarase that distinguish between the active site and a nearby dicarboxylic acid binding site.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolyase
molecule keywords FUMARASE C
total genus 168
structure length 456
sequence length 456
chains with identical sequence B
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 1997-01-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 1furA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1furA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1furA02
1T6JA 2PFMA 1EB4A 1Q5NA 1RE5A 3R6QA 4V2QA 1C3UA 4C5UA 2FUSA 2VD6A 1W27A 2YIIA 2OHYA 1GK2A 1C3CA 2O7BA 4EFCA 3GTDA 2O7EA 5F91A 2QVEA 3NZ4A 3RRPA 3OCEA 2O6YA 1U15A 3OCFA 4APAA 4FFXA 1U16A 1TJ7A 1FURA 2X75A 1HY0A 4NLEA 1FUQA 1Y2MA 2RJSA 1GK3A 5D6BA 1J3UA 3C8TA 4CQ5A 1I0AA 1DCNA 5HW2A 2J91A 1GKJA 3QBPA 1GKMA 1JSWA 4C5SA 2NYFA 5F92A 3RD8A 4BABA 4MX2A 1YFEA 2HVGA 3R6VA 1TJUA 1B8FA 4APBA 2RJRA 2PTQA 1FUOA 1T6PA 1YFMA 1VDKA 3TV2A 5EYTA 2NYNA 3R6YA 3BHGA 5EYVA 4NSLA 4FLCA 3GZHA 4BAAA 3NO9A 2E9FA 1FUPA 1K62A 1KQ7A 4V2RA 1K7WA 2QGAB 1YISA 3CZOA 3KDYA 2O78A 4HGVA 3KDZA 2PTRA 4ADMA 2O7DA 3E04A 4C5RA 2PTSA 1AUWA 1TJWA 4C6GA 1XWOA 4EEIA 1TJVA 2O7FA 3UNVA 1DOFA 4ADLA 1HY1A
chains in the Genus database with same CATH superfamily
1T6JA 2PFMA 1EB4A 1Q5NA 2JARA 1RE5A 3R6QA 1Z4LA 3CRW1 3F4RA 4V2QA 1Z4PX 1C3UA 2FELA 2JAOA 4C5UA 2FUSA 3F4TA 1W27A 4MWOA 2VD6A 2YIIA 2OHYA 1GK2A 1C3CA 4L57A 2O7BA 4EFCA 3GTDA 2O7EA 5F91A 2QVEA 3NZ4A 3RRPA 1MH9A 3OCEA 2O6YA 1U15A 3OCFA 4APAA 3CI0K 3F4SA 1Z4KA 2RCNA 4FFXA 1U16A 1TJ7A 3U13A 1FURA 2X75A 4L6CA 1HY0A 4NLEA 1FUQA 1Y2MA 2RJSA 1GK3A 2VSFA 5D6BA 1Q91A 1J3UA 3U19A 3C8TA 4CQ5A 1I0AA 2I7DA 2JAWA 1DCNA 1T9HA 5HW2A 2J91A 1GKJA 3QBPA 1Z4QA 1GKMA 1JSWA 4C5SA 2NYFA 4A15A 5F92A 1Z4MA 1XL7A 5M0JA 3RD8A 1Z4JA 4BABA 4MX2A 1YFEA 4YIHA 2HVGA 3R6VA 1IW7D 1TJUA 1B8FA 4E88A 4APBA 2RJRA 1XMDA 2D27A 2PTQA 1XL8A 1FUOA 2JAUA 1T6PA 1Q92A 1VDKA 1YFMA 4L6AA 5M0IA 3TV2A 2VL7A 5EYTA 2FENA 2NYNA 1XMCA 3R6YA 3BHGA 5EYVA 4NSLA 4FLCA 3GZHA 4BAAA 3NO9A 2E9FA 1FUPA 1K62A 1KQ7A 4V2RA 1K7WA 2QGAB 1U0LA 1YISA 3CZOA 3KDYA 2O78A 4NFLA 4MUMA 4HGVA 3KDZA 2PTRA 4ADMA 2D28C 3CRVA 2O7DA 3E04A 4C5RA 4WNLA 2PTSA 1AUWA 1TJWA 2YV5A 4YIKA 1Z4IA 3BWVA 4C6GA 1XWOA 4EEIA 1XLYA 1TJVA 2O7FA 3UNVA 5H8WA 1DOFA 4ADLA 1HY1A 4IQJM
chains in the Genus database with same CATH topology
1T6JA 2PFMA 1EB4A 1Q5NA 1RE5A 3R6QA 4V2QA 1C3UA 4C5UA 2FUSA 2VD6A 1W27A 2YIIA 2OHYA 1GK2A 1C3CA 2O7BA 4EFCA 3GTDA 2O7EA 5F91A 2QVEA 3NZ4A 3RRPA 3OCEA 2O6YA 1U15A 3OCFA 4APAA 4FFXA 1U16A 1TJ7A 1FURA 2X75A 1HY0A 4NLEA 1FUQA 1Y2MA 2RJSA 1GK3A 5D6BA 1J3UA 3C8TA 4CQ5A 1I0AA 1DCNA 5HW2A 2J91A 1GKJA 3QBPA 1GKMA 1JSWA 4C5SA 2NYFA 5F92A 3RD8A 4BABA 4MX2A 1YFEA 2HVGA 3R6VA 1TJUA 1B8FA 4APBA 2RJRA 2PTQA 1FUOA 1T6PA 1YFMA 1VDKA 3TV2A 5EYTA 2NYNA 3R6YA 3BHGA 5EYVA 4NSLA 4FLCA 3GZHA 4BAAA 3NO9A 2E9FA 1FUPA 1K62A 1KQ7A 4V2RA 1K7WA 2QGAB 1YISA 3CZOA 3KDYA 2O78A 4HGVA 3KDZA 2PTRA 4ADMA 2O7DA 3E04A 4C5RA 2PTSA 1AUWA 1TJWA 4C6GA 1XWOA 4EEIA 1TJVA 2O7FA 3UNVA 1DOFA 4ADLA 1HY1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1T6J A;  2PFM A;  1EB4 A;  1Q5N A;  1RE5 A;  3R6Q A;  4V2Q A;  1C3U A;  4C5U A;  2FUS A;  2VD6 A;  1W27 A;  2YII A;  2OHY A;  1GK2 A;  1C3C A;  2O7B A;  4EFC A;  3GTD A;  2O7E A;  5F91 A;  2QVE A;  3NZ4 A;  3RRP A;  3OCE A;  2O6Y A;  1U15 A;  3OCF A;  4APA A;  4FFX A;  1U16 A;  1TJ7 A;  1FUR A;  2X75 A;  1HY0 A;  4NLE A;  1FUQ A;  1Y2M A;  2RJS A;  1GK3 A;  5D6B A;  1J3U A;  3C8T A;  4CQ5 A;  1I0A A;  1DCN A;  5HW2 A;  2J91 A;  1GKJ A;  3QBP A;  1GKM A;  1JSW A;  4C5S A;  2NYF A;  5F92 A;  3RD8 A;  4BAB A;  4MX2 A;  1YFE A;  2HVG A;  3R6V A;  1TJU A;  1B8F A;  4APB A;  2RJR A;  2PTQ A;  1FUO A;  1T6P A;  1YFM A;  1VDK A;  3TV2 A;  5EYT A;  2NYN A;  3R6Y A;  3BHG A;  5EYV A;  4NSL A;  4FLC A;  3GZH A;  4BAA A;  3NO9 A;  2E9F A;  1FUP A;  1K62 A;  1KQ7 A;  4V2R A;  1K7W A;  2QGA B;  1YIS A;  3CZO A;  3KDY A;  2O78 A;  4HGV A;  3KDZ A;  2PTR A;  4ADM A;  2O7D A;  3E04 A;  4C5R A;  2PTS A;  1AUW A;  1TJW A;  4C6G A;  1XWO A;  4EEI A;  1TJV A;  2O7F A;  3UNV A;  1DOF A;  4ADL A;  1HY1 A; 
#chains in the Genus database with same CATH topology
 1T6J A;  2PFM A;  1EB4 A;  1Q5N A;  2JAR A;  1RE5 A;  3R6Q A;  1Z4L A;  3CRW 1;  3F4R A;  4V2Q A;  1Z4P X;  1C3U A;  2FEL A;  2JAO A;  4C5U A;  2FUS A;  3F4T A;  1W27 A;  4MWO A;  2VD6 A;  2YII A;  2OHY A;  1GK2 A;  1C3C A;  4L57 A;  2O7B A;  4EFC A;  3GTD A;  2O7E A;  5F91 A;  2QVE A;  3NZ4 A;  3RRP A;  1MH9 A;  3OCE A;  2O6Y A;  1U15 A;  3OCF A;  4APA A;  3CI0 K;  3F4S A;  1Z4K A;  2RCN A;  4FFX A;  1U16 A;  1TJ7 A;  3U13 A;  1FUR A;  2X75 A;  4L6C A;  1HY0 A;  4NLE A;  1FUQ A;  1Y2M A;  2RJS A;  1GK3 A;  2VSF A;  5D6B A;  1Q91 A;  1J3U A;  3U19 A;  3C8T A;  4CQ5 A;  1I0A A;  2I7D A;  2JAW A;  1DCN A;  1T9H A;  5HW2 A;  2J91 A;  1GKJ A;  3QBP A;  1Z4Q A;  1GKM A;  1JSW A;  4C5S A;  2NYF A;  4A15 A;  5F92 A;  1Z4M A;  1XL7 A;  5M0J A;  3RD8 A;  1Z4J A;  4BAB A;  4MX2 A;  1YFE A;  4YIH A;  2HVG A;  3R6V A;  1IW7 D;  1TJU A;  1B8F A;  4E88 A;  4APB A;  2RJR A;  1XMD A;  2D27 A;  2PTQ A;  1XL8 A;  1FUO A;  2JAU A;  1T6P A;  1Q92 A;  1VDK A;  1YFM A;  4L6A A;  5M0I A;  3TV2 A;  2VL7 A;  5EYT A;  2FEN A;  2NYN A;  1XMC A;  3R6Y A;  3BHG A;  5EYV A;  4NSL A;  4FLC A;  3GZH A;  4BAA A;  3NO9 A;  2E9F A;  1FUP A;  1K62 A;  1KQ7 A;  4V2R A;  1K7W A;  2QGA B;  1U0L A;  1YIS A;  3CZO A;  3KDY A;  2O78 A;  4NFL A;  4MUM A;  4HGV A;  3KDZ A;  2PTR A;  4ADM A;  2D28 C;  3CRV A;  2O7D A;  3E04 A;  4C5R A;  4WNL A;  2PTS A;  1AUW A;  1TJW A;  2YV5 A;  4YIK A;  1Z4I A;  3BWV A;  4C6G A;  1XWO A;  4EEI A;  1XLY A;  1TJV A;  2O7F A;  3UNV A;  5H8W A;  1DOF A;  4ADL A;  1HY1 A;  4IQJ M; 
#chains in the Genus database with same CATH homology
 1T6J A;  2PFM A;  1EB4 A;  1Q5N A;  1RE5 A;  3R6Q A;  4V2Q A;  1C3U A;  4C5U A;  2FUS A;  2VD6 A;  1W27 A;  2YII A;  2OHY A;  1GK2 A;  1C3C A;  2O7B A;  4EFC A;  3GTD A;  2O7E A;  5F91 A;  2QVE A;  3NZ4 A;  3RRP A;  3OCE A;  2O6Y A;  1U15 A;  3OCF A;  4APA A;  4FFX A;  1U16 A;  1TJ7 A;  1FUR A;  2X75 A;  1HY0 A;  4NLE A;  1FUQ A;  1Y2M A;  2RJS A;  1GK3 A;  5D6B A;  1J3U A;  3C8T A;  4CQ5 A;  1I0A A;  1DCN A;  5HW2 A;  2J91 A;  1GKJ A;  3QBP A;  1GKM A;  1JSW A;  4C5S A;  2NYF A;  5F92 A;  3RD8 A;  4BAB A;  4MX2 A;  1YFE A;  2HVG A;  3R6V A;  1TJU A;  1B8F A;  4APB A;  2RJR A;  2PTQ A;  1FUO A;  1T6P A;  1YFM A;  1VDK A;  3TV2 A;  5EYT A;  2NYN A;  3R6Y A;  3BHG A;  5EYV A;  4NSL A;  4FLC A;  3GZH A;  4BAA A;  3NO9 A;  2E9F A;  1FUP A;  1K62 A;  1KQ7 A;  4V2R A;  1K7W A;  2QGA B;  1YIS A;  3CZO A;  3KDY A;  2O78 A;  4HGV A;  3KDZ A;  2PTR A;  4ADM A;  2O7D A;  3E04 A;  4C5R A;  2PTS A;  1AUW A;  1TJW A;  4C6G A;  1XWO A;  4EEI A;  1TJV A;  2O7F A;  3UNV A;  1DOF A;  4ADL A;  1HY1 A; 
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similar chains in the pdb database (?% sequence similarity)

 
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