1FURA

Fumarase mutant h188n with bound substrate l-malate at putative activator site
Total Genus 168
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
168
sequence length
456
structure length
456
Chain Sequence
b'VRSEKDSMGAIDVPADKLWGAQTQRSLEHFRISTEKMPTSLIHALALTKRAAAKVNEDLGLLSEEKASAIRQAADEVLAGQHDDEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGVRGMERKVHPNDDVNKSQSSNDVFPTAMHVAALLALRKQLIPQLKTLTQTLNEKSRAFADIVKIGRTNLQDATPLTLGQEISGWVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYARRVADELAVITCAPFVTAPNKFEALATCDALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEISIPENEPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHNFLQSVRLLADGMESFNKHCAVGIEPNRERINQLLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAALALGYLSEAEFDSWVRPEQM'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords FUMARASE C
publication title Mutations of fumarase that distinguish between the active site and a nearby dicarboxylic acid binding site.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolyase
total genus 168
structure length 456
sequence length 456
chains with identical sequence B
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 1997-01-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 1furA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1furA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1furA02
1C3CA 3QBPA 1TJWA 1U15A 1KQ7A 1TJVA 1TJUA 1JSWA 3TV2A 5F91A 1T6JA 4C5UA 3KDYA 2PFMA 2E9FA 4BAAA 3C8TA 1FUPA 3RD8A 1FUQA 1I0AA 2YIIA 2J91A 5EYTA 1U16A 2NYNA 1W27A 3GTDA 3R6QA 1GKMA 4APBA 1DCNA 5EYVA 4V2RA 4MX2A 4APAA 1FUOA 4C5SA 2O6YA 3UNVA 3KDZA 3R6YA 1GKJA 3NZ4A 1YISA 1GK2A 4CQ5A 2RJSA 1YFMA 2PTSA 2PTRA 1XWOA 2PTQA 1GK3A 4V2QA 1HY1A 2QVEA 4FLCA 1Y2MA 1C3UA 3CZOA 4BABA 1YFEA 2O7BA 3R6VA 1TJ7A 3NO9A 2O7DA 4ADLA 2VD6A 3OCFA 1DOFA 5F92A 5HW2A 1VDKA 1T6PA 4EFCA 3E04A 2O7EA 1RE5A 4HGVA 2X75A 4EEIA 4NLEA 2FUSA 1AUWA 2NYFA 1Q5NA 2QGAB 2OHYA 1FURA 3OCEA 4ADMA 3BHGA 3GZHA 2O7FA 1EB4A 2HVGA 4C6GA 5D6BA 1J3UA 2O78A 1K62A 1HY0A 4FFXA 3RRPA 1B8FA 1K7WA 2RJRA 4C5RA 4NSLA
chains in the Genus database with same CATH superfamily
1C3CA 3QBPA 1TJWA 1U15A 1KQ7A 2JAWA 3U19A 1TJVA 1TJUA 1JSWA 3TV2A 5F91A 2VSFA 1T6JA 4C5UA 3KDYA 2PFMA 2VL7A 5H8WA 2E9FA 4BAAA 5M0IA 3C8TA 1FUPA 1Z4KA 3F4RA 3RD8A 3CRW1 1FUQA 2RCNA 1I0AA 2YIIA 1Z4PX 2J91A 3CRVA 5EYTA 1U16A 2NYNA 1W27A 3GTDA 4IQJM 2FENA 4NFLA 3R6QA 1GKMA 1IW7D 4APBA 1DCNA 5EYVA 3U13A 1XL7A 2FELA 4V2RA 3F4SA 4MX2A 2D28C 4APAA 2D27A 1FUOA 2YV5A 4C5SA 2O6YA 1XMDA 1Z4LA 1XL8A 3UNVA 3KDZA 3R6YA 1GKJA 2JAOA 1XMCA 3NZ4A 1YISA 1XLYA 1GK2A 1Z4JA 2JAUA 2RJSA 4CQ5A 1YFMA 2PTSA 2PTRA 1XWOA 2PTQA 1GK3A 4V2QA 1HY1A 3BWVA 4WNLA 4MWOA 2QVEA 1Y2MA 4FLCA 1C3UA 3CZOA 4BABA 1YFEA 3CI0K 4YIKA 2O7BA 1Q92A 2JARA 3R6VA 5M0JA 1TJ7A 3NO9A 2O7DA 4ADLA 2VD6A 3OCFA 1DOFA 5F92A 5HW2A 1VDKA 1T6PA 4EFCA 3E04A 2O7EA 2I7DA 1RE5A 4HGVA 2X75A 4EEIA 4A15A 4NLEA 2FUSA 1AUWA 2NYFA 1Q5NA 2QGAB 2OHYA 1FURA 1Z4IA 3OCEA 4ADMA 3BHGA 4L6AA 3GZHA 1Z4MA 4L57A 2O7FA 1EB4A 4L6CA 4YIHA 2HVGA 4C6GA 5D6BA 1J3UA 1MH9A 2O78A 3F4TA 1K62A 1HY0A 1Z4QA 4FFXA 3RRPA 1B8FA 1K7WA 4MUMA 2RJRA 1Q91A 4C5RA 4E88A 1U0LA 4NSLA 1T9HA
chains in the Genus database with same CATH topology
1C3CA 3QBPA 1TJWA 1U15A 1KQ7A 1TJVA 1TJUA 1JSWA 3TV2A 5F91A 1T6JA 4C5UA 3KDYA 2PFMA 2E9FA 4BAAA 3C8TA 1FUPA 3RD8A 1FUQA 1I0AA 2YIIA 2J91A 5EYTA 1U16A 2NYNA 1W27A 3GTDA 3R6QA 1GKMA 4APBA 1DCNA 5EYVA 4V2RA 4MX2A 4APAA 1FUOA 4C5SA 2O6YA 3UNVA 3KDZA 3R6YA 1GKJA 3NZ4A 1YISA 1GK2A 4CQ5A 2RJSA 1YFMA 2PTSA 2PTRA 1XWOA 2PTQA 1GK3A 4V2QA 1HY1A 2QVEA 4FLCA 1Y2MA 1C3UA 3CZOA 4BABA 1YFEA 2O7BA 3R6VA 1TJ7A 3NO9A 2O7DA 4ADLA 2VD6A 3OCFA 1DOFA 5F92A 5HW2A 1VDKA 1T6PA 4EFCA 3E04A 2O7EA 1RE5A 4HGVA 2X75A 4EEIA 4NLEA 2FUSA 1AUWA 2NYFA 1Q5NA 2QGAB 2OHYA 1FURA 3OCEA 4ADMA 3BHGA 3GZHA 2O7FA 1EB4A 2HVGA 4C6GA 5D6BA 1J3UA 2O78A 1K62A 1HY0A 4FFXA 3RRPA 1B8FA 1K7WA 2RJRA 4C5RA 4NSLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C3C A;  3QBP A;  1TJW A;  1U15 A;  1KQ7 A;  1TJV A;  1TJU A;  1JSW A;  3TV2 A;  5F91 A;  1T6J A;  4C5U A;  3KDY A;  2PFM A;  2E9F A;  4BAA A;  3C8T A;  1FUP A;  3RD8 A;  1FUQ A;  1I0A A;  2YII A;  2J91 A;  5EYT A;  1U16 A;  2NYN A;  1W27 A;  3GTD A;  3R6Q A;  1GKM A;  4APB A;  1DCN A;  5EYV A;  4V2R A;  4MX2 A;  4APA A;  1FUO A;  4C5S A;  2O6Y A;  3UNV A;  3KDZ A;  3R6Y A;  1GKJ A;  3NZ4 A;  1YIS A;  1GK2 A;  4CQ5 A;  2RJS A;  1YFM A;  2PTS A;  2PTR A;  1XWO A;  2PTQ A;  1GK3 A;  4V2Q A;  1HY1 A;  2QVE A;  4FLC A;  1Y2M A;  1C3U A;  3CZO A;  4BAB A;  1YFE A;  2O7B A;  3R6V A;  1TJ7 A;  3NO9 A;  2O7D A;  4ADL A;  2VD6 A;  3OCF A;  1DOF A;  5F92 A;  5HW2 A;  1VDK A;  1T6P A;  4EFC A;  3E04 A;  2O7E A;  1RE5 A;  4HGV A;  2X75 A;  4EEI A;  4NLE A;  2FUS A;  1AUW A;  2NYF A;  1Q5N A;  2QGA B;  2OHY A;  1FUR A;  3OCE A;  4ADM A;  3BHG A;  3GZH A;  2O7F A;  1EB4 A;  2HVG A;  4C6G A;  5D6B A;  1J3U A;  2O78 A;  1K62 A;  1HY0 A;  4FFX A;  3RRP A;  1B8F A;  1K7W A;  2RJR A;  4C5R A;  4NSL A; 
#chains in the Genus database with same CATH topology
 1C3C A;  3QBP A;  1TJW A;  1U15 A;  1KQ7 A;  2JAW A;  3U19 A;  1TJV A;  1TJU A;  1JSW A;  3TV2 A;  5F91 A;  2VSF A;  1T6J A;  4C5U A;  3KDY A;  2PFM A;  2VL7 A;  5H8W A;  2E9F A;  4BAA A;  5M0I A;  3C8T A;  1FUP A;  1Z4K A;  3F4R A;  3RD8 A;  3CRW 1;  1FUQ A;  2RCN A;  1I0A A;  2YII A;  1Z4P X;  2J91 A;  3CRV A;  5EYT A;  1U16 A;  2NYN A;  1W27 A;  3GTD A;  4IQJ M;  2FEN A;  4NFL A;  3R6Q A;  1GKM A;  1IW7 D;  4APB A;  1DCN A;  5EYV A;  3U13 A;  1XL7 A;  2FEL A;  4V2R A;  3F4S A;  4MX2 A;  2D28 C;  4APA A;  2D27 A;  1FUO A;  2YV5 A;  4C5S A;  2O6Y A;  1XMD A;  1Z4L A;  1XL8 A;  3UNV A;  3KDZ A;  3R6Y A;  1GKJ A;  2JAO A;  1XMC A;  3NZ4 A;  1YIS A;  1XLY A;  1GK2 A;  1Z4J A;  2JAU A;  2RJS A;  4CQ5 A;  1YFM A;  2PTS A;  2PTR A;  1XWO A;  2PTQ A;  1GK3 A;  4V2Q A;  1HY1 A;  3BWV A;  4WNL A;  4MWO A;  2QVE A;  1Y2M A;  4FLC A;  1C3U A;  3CZO A;  4BAB A;  1YFE A;  3CI0 K;  4YIK A;  2O7B A;  1Q92 A;  2JAR A;  3R6V A;  5M0J A;  1TJ7 A;  3NO9 A;  2O7D A;  4ADL A;  2VD6 A;  3OCF A;  1DOF A;  5F92 A;  5HW2 A;  1VDK A;  1T6P A;  4EFC A;  3E04 A;  2O7E A;  2I7D A;  1RE5 A;  4HGV A;  2X75 A;  4EEI A;  4A15 A;  4NLE A;  2FUS A;  1AUW A;  2NYF A;  1Q5N A;  2QGA B;  2OHY A;  1FUR A;  1Z4I A;  3OCE A;  4ADM A;  3BHG A;  4L6A A;  3GZH A;  1Z4M A;  4L57 A;  2O7F A;  1EB4 A;  4L6C A;  4YIH A;  2HVG A;  4C6G A;  5D6B A;  1J3U A;  1MH9 A;  2O78 A;  3F4T A;  1K62 A;  1HY0 A;  1Z4Q A;  4FFX A;  3RRP A;  1B8F A;  1K7W A;  4MUM A;  2RJR A;  1Q91 A;  4C5R A;  4E88 A;  1U0L A;  4NSL A;  1T9H A; 
#chains in the Genus database with same CATH homology
 1C3C A;  3QBP A;  1TJW A;  1U15 A;  1KQ7 A;  1TJV A;  1TJU A;  1JSW A;  3TV2 A;  5F91 A;  1T6J A;  4C5U A;  3KDY A;  2PFM A;  2E9F A;  4BAA A;  3C8T A;  1FUP A;  3RD8 A;  1FUQ A;  1I0A A;  2YII A;  2J91 A;  5EYT A;  1U16 A;  2NYN A;  1W27 A;  3GTD A;  3R6Q A;  1GKM A;  4APB A;  1DCN A;  5EYV A;  4V2R A;  4MX2 A;  4APA A;  1FUO A;  4C5S A;  2O6Y A;  3UNV A;  3KDZ A;  3R6Y A;  1GKJ A;  3NZ4 A;  1YIS A;  1GK2 A;  4CQ5 A;  2RJS A;  1YFM A;  2PTS A;  2PTR A;  1XWO A;  2PTQ A;  1GK3 A;  4V2Q A;  1HY1 A;  2QVE A;  4FLC A;  1Y2M A;  1C3U A;  3CZO A;  4BAB A;  1YFE A;  2O7B A;  3R6V A;  1TJ7 A;  3NO9 A;  2O7D A;  4ADL A;  2VD6 A;  3OCF A;  1DOF A;  5F92 A;  5HW2 A;  1VDK A;  1T6P A;  4EFC A;  3E04 A;  2O7E A;  1RE5 A;  4HGV A;  2X75 A;  4EEI A;  4NLE A;  2FUS A;  1AUW A;  2NYF A;  1Q5N A;  2QGA B;  2OHY A;  1FUR A;  3OCE A;  4ADM A;  3BHG A;  3GZH A;  2O7F A;  1EB4 A;  2HVG A;  4C6G A;  5D6B A;  1J3U A;  2O78 A;  1K62 A;  1HY0 A;  4FFX A;  3RRP A;  1B8F A;  1K7W A;  2RJR A;  4C5R A;  4NSL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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