1KQ7A

E315q mutant form of fumarase c from e.coli
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
sequence length
456
structure length
456
Chain Sequence
VRSEKDSMGAIDVPADKLWGAQTQRSLEHFRISTEKMPTSLIHALALTKRAAAKVNEDLGLLSEEKASAIRQAADEVLAGQHDDEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGVRGMERKVHPNDDVNKSQSSNDVFPTAMHVAALLALRKQLIPQLKTLTQTLNEKSRAFADIVKIGRTHLQDATPLTLGQEISGWVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYARRVADELAVITCAPFVTAPNKFEALATCDALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEISIPENQPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHNFLQSVRLLADGMESFNKHCAVGIEPNRERINQLLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAALALGYLSEAEFDSWVRPEQM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lyase
molecule keywords FUMARATE HYDRATASE CLASS II
publication title X-ray crystallographic and kinetic correlation of a clinically observed human fumarase mutation.
pubmed doi rcsb
source organism Escherichia coli
total genus 162
structure length 456
sequence length 456
chains with identical sequence B
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2002-01-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 1kq7A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1kq7A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1kq7A02
3CZOA 4C5UA 5F92A 4BABA 2PTRA 2J91A 4BAAA 1C3CA 2YIIA 1VDKA 1YFEA 1U15A 4V2RA 1XWOA 3RRPA 1TJ7A 4C5SA 5EYVA 1FUPA 4NLEA 3OCFA 3GTDA 5D6BA 2RJRA 2PFMA 1FUOA 1KQ7A 1EB4A 1DOFA 3NZ4A 3QBPA 2RJSA 3KDYA 4EFCA 4APBA 2O7FA 4FLCA 2QGAB 4C6GA 4C5RA 4NSLA 2PTQA 1DCNA 2O7DA 3E04A 4HGVA 4MX2A 1I0AA 3R6YA 1W27A 2VD6A 3GZHA 2NYFA 1FUQA 1U16A 2X75A 2NYNA 1HY1A 1Q5NA 1T6PA 4EEIA 4FFXA 2E9FA 3OCEA 2QVEA 3NO9A 1C3UA 3BHGA 1TJUA 2OHYA 5F91A 1TJVA 2O7BA 1T6JA 2PTSA 1FURA 1K7WA 1Y2MA 1GKJA 1GK2A 1YISA 5EYTA 4V2QA 1K62A 2O7EA 4ADLA 3UNVA 3R6QA 1TJWA 3R6VA 1AUWA 3TV2A 1YFMA 1J3UA 1GK3A 4APAA 1GKMA 3C8TA 2O6YA 2HVGA 1RE5A 4ADMA 1JSWA 3RD8A 4CQ5A 2FUSA 5HW2A 1B8FA 2O78A 1HY0A 3KDZA
chains in the Genus database with same CATH superfamily
3CZOA 4C5UA 5F92A 4BABA 2PTRA 2J91A 4BAAA 1C3CA 2YIIA 2JARA 2RCNA 2FELA 1VDKA 1Z4QA 1YFEA 1U15A 4V2RA 4L57A 4NFLA 1XWOA 3RRPA 1TJ7A 3CI0K 4C5SA 1Z4JA 5EYVA 1FUPA 3BWVA 4NLEA 3OCFA 4E88A 2FENA 2D28C 3GTDA 1XL7A 5D6BA 4L6AA 3F4RA 2RJRA 1Z4MA 2VL7A 2PFMA 1FUOA 1KQ7A 1EB4A 1DOFA 3NZ4A 3QBPA 2RJSA 3KDYA 1Z4PX 4EFCA 4APBA 2O7FA 4FLCA 2QGAB 5M0JA 4C6GA 4C5RA 3CRW1 5M0IA 4NSLA 1IW7D 3F4TA 2PTQA 1DCNA 2O7DA 3E04A 4HGVA 4MX2A 1I0AA 3R6YA 1W27A 2JAUA 1XL8A 2VD6A 1Z4KA 3GZHA 4YIHA 2VSFA 2NYFA 4WNLA 1FUQA 1U16A 2X75A 3U13A 1T9HA 2NYNA 1HY1A 2I7DA 1Q5NA 1T6PA 4EEIA 4FFXA 2E9FA 3F4SA 3OCEA 2QVEA 3NO9A 1C3UA 1Q91A 3BHGA 1TJUA 2OHYA 3CRVA 3U19A 2YV5A 1TJVA 5F91A 5H8WA 1MH9A 2O7BA 1T6JA 2PTSA 1FURA 1K7WA 4IQJM 2JAWA 1Y2MA 1GKJA 1GK2A 1YISA 5EYTA 4V2QA 1K62A 2O7EA 4ADLA 4L6CA 3UNVA 3R6QA 1Q92A 1TJWA 3R6VA 1AUWA 1Z4LA 4MWOA 1XMCA 1XMDA 3TV2A 1YFMA 4A15A 1J3UA 1XLYA 1GK3A 4APAA 1GKMA 3C8TA 2O6YA 2HVGA 4YIKA 1RE5A 4ADMA 1JSWA 2D27A 3RD8A 4CQ5A 2FUSA 4MUMA 5HW2A 1B8FA 1Z4IA 2O78A 1HY0A 2JAOA 3KDZA 1U0LA
chains in the Genus database with same CATH topology
3CZOA 4C5UA 5F92A 4BABA 2PTRA 2J91A 4BAAA 1C3CA 2YIIA 1VDKA 1YFEA 1U15A 4V2RA 1XWOA 3RRPA 1TJ7A 4C5SA 5EYVA 1FUPA 4NLEA 3OCFA 3GTDA 5D6BA 2RJRA 2PFMA 1FUOA 1KQ7A 1EB4A 1DOFA 3NZ4A 3QBPA 2RJSA 3KDYA 4EFCA 4APBA 2O7FA 4FLCA 2QGAB 4C6GA 4C5RA 4NSLA 2PTQA 1DCNA 2O7DA 3E04A 4HGVA 4MX2A 1I0AA 3R6YA 1W27A 2VD6A 3GZHA 2NYFA 1FUQA 1U16A 2X75A 2NYNA 1HY1A 1Q5NA 1T6PA 4EEIA 4FFXA 2E9FA 3OCEA 2QVEA 3NO9A 1C3UA 3BHGA 1TJUA 2OHYA 5F91A 1TJVA 2O7BA 1T6JA 2PTSA 1FURA 1K7WA 1Y2MA 1GKJA 1GK2A 1YISA 5EYTA 4V2QA 1K62A 2O7EA 4ADLA 3UNVA 3R6QA 1TJWA 3R6VA 1AUWA 3TV2A 1YFMA 1J3UA 1GK3A 4APAA 1GKMA 3C8TA 2O6YA 2HVGA 1RE5A 4ADMA 1JSWA 3RD8A 4CQ5A 2FUSA 5HW2A 1B8FA 2O78A 1HY0A 3KDZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CZO A;  4C5U A;  5F92 A;  4BAB A;  2PTR A;  2J91 A;  4BAA A;  1C3C A;  2YII A;  1VDK A;  1YFE A;  1U15 A;  4V2R A;  1XWO A;  3RRP A;  1TJ7 A;  4C5S A;  5EYV A;  1FUP A;  4NLE A;  3OCF A;  3GTD A;  5D6B A;  2RJR A;  2PFM A;  1FUO A;  1KQ7 A;  1EB4 A;  1DOF A;  3NZ4 A;  3QBP A;  2RJS A;  3KDY A;  4EFC A;  4APB A;  2O7F A;  4FLC A;  2QGA B;  4C6G A;  4C5R A;  4NSL A;  2PTQ A;  1DCN A;  2O7D A;  3E04 A;  4HGV A;  4MX2 A;  1I0A A;  3R6Y A;  1W27 A;  2VD6 A;  3GZH A;  2NYF A;  1FUQ A;  1U16 A;  2X75 A;  2NYN A;  1HY1 A;  1Q5N A;  1T6P A;  4EEI A;  4FFX A;  2E9F A;  3OCE A;  2QVE A;  3NO9 A;  1C3U A;  3BHG A;  1TJU A;  2OHY A;  5F91 A;  1TJV A;  2O7B A;  1T6J A;  2PTS A;  1FUR A;  1K7W A;  1Y2M A;  1GKJ A;  1GK2 A;  1YIS A;  5EYT A;  4V2Q A;  1K62 A;  2O7E A;  4ADL A;  3UNV A;  3R6Q A;  1TJW A;  3R6V A;  1AUW A;  3TV2 A;  1YFM A;  1J3U A;  1GK3 A;  4APA A;  1GKM A;  3C8T A;  2O6Y A;  2HVG A;  1RE5 A;  4ADM A;  1JSW A;  3RD8 A;  4CQ5 A;  2FUS A;  5HW2 A;  1B8F A;  2O78 A;  1HY0 A;  3KDZ A; 
#chains in the Genus database with same CATH topology
 3CZO A;  4C5U A;  5F92 A;  4BAB A;  2PTR A;  2J91 A;  4BAA A;  1C3C A;  2YII A;  2JAR A;  2RCN A;  2FEL A;  1VDK A;  1Z4Q A;  1YFE A;  1U15 A;  4V2R A;  4L57 A;  4NFL A;  1XWO A;  3RRP A;  1TJ7 A;  3CI0 K;  4C5S A;  1Z4J A;  5EYV A;  1FUP A;  3BWV A;  4NLE A;  3OCF A;  4E88 A;  2FEN A;  2D28 C;  3GTD A;  1XL7 A;  5D6B A;  4L6A A;  3F4R A;  2RJR A;  1Z4M A;  2VL7 A;  2PFM A;  1FUO A;  1KQ7 A;  1EB4 A;  1DOF A;  3NZ4 A;  3QBP A;  2RJS A;  3KDY A;  1Z4P X;  4EFC A;  4APB A;  2O7F A;  4FLC A;  2QGA B;  5M0J A;  4C6G A;  4C5R A;  3CRW 1;  5M0I A;  4NSL A;  1IW7 D;  3F4T A;  2PTQ A;  1DCN A;  2O7D A;  3E04 A;  4HGV A;  4MX2 A;  1I0A A;  3R6Y A;  1W27 A;  2JAU A;  1XL8 A;  2VD6 A;  1Z4K A;  3GZH A;  4YIH A;  2VSF A;  2NYF A;  4WNL A;  1FUQ A;  1U16 A;  2X75 A;  3U13 A;  1T9H A;  2NYN A;  1HY1 A;  2I7D A;  1Q5N A;  1T6P A;  4EEI A;  4FFX A;  2E9F A;  3F4S A;  3OCE A;  2QVE A;  3NO9 A;  1C3U A;  1Q91 A;  3BHG A;  1TJU A;  2OHY A;  3CRV A;  3U19 A;  2YV5 A;  1TJV A;  5F91 A;  5H8W A;  1MH9 A;  2O7B A;  1T6J A;  2PTS A;  1FUR A;  1K7W A;  4IQJ M;  2JAW A;  1Y2M A;  1GKJ A;  1GK2 A;  1YIS A;  5EYT A;  4V2Q A;  1K62 A;  2O7E A;  4ADL A;  4L6C A;  3UNV A;  3R6Q A;  1Q92 A;  1TJW A;  3R6V A;  1AUW A;  1Z4L A;  4MWO A;  1XMC A;  1XMD A;  3TV2 A;  1YFM A;  4A15 A;  1J3U A;  1XLY A;  1GK3 A;  4APA A;  1GKM A;  3C8T A;  2O6Y A;  2HVG A;  4YIK A;  1RE5 A;  4ADM A;  1JSW A;  2D27 A;  3RD8 A;  4CQ5 A;  2FUS A;  4MUM A;  5HW2 A;  1B8F A;  1Z4I A;  2O78 A;  1HY0 A;  2JAO A;  3KDZ A;  1U0L A; 
#chains in the Genus database with same CATH homology
 3CZO A;  4C5U A;  5F92 A;  4BAB A;  2PTR A;  2J91 A;  4BAA A;  1C3C A;  2YII A;  1VDK A;  1YFE A;  1U15 A;  4V2R A;  1XWO A;  3RRP A;  1TJ7 A;  4C5S A;  5EYV A;  1FUP A;  4NLE A;  3OCF A;  3GTD A;  5D6B A;  2RJR A;  2PFM A;  1FUO A;  1KQ7 A;  1EB4 A;  1DOF A;  3NZ4 A;  3QBP A;  2RJS A;  3KDY A;  4EFC A;  4APB A;  2O7F A;  4FLC A;  2QGA B;  4C6G A;  4C5R A;  4NSL A;  2PTQ A;  1DCN A;  2O7D A;  3E04 A;  4HGV A;  4MX2 A;  1I0A A;  3R6Y A;  1W27 A;  2VD6 A;  3GZH A;  2NYF A;  1FUQ A;  1U16 A;  2X75 A;  2NYN A;  1HY1 A;  1Q5N A;  1T6P A;  4EEI A;  4FFX A;  2E9F A;  3OCE A;  2QVE A;  3NO9 A;  1C3U A;  3BHG A;  1TJU A;  2OHY A;  5F91 A;  1TJV A;  2O7B A;  1T6J A;  2PTS A;  1FUR A;  1K7W A;  1Y2M A;  1GKJ A;  1GK2 A;  1YIS A;  5EYT A;  4V2Q A;  1K62 A;  2O7E A;  4ADL A;  3UNV A;  3R6Q A;  1TJW A;  3R6V A;  1AUW A;  3TV2 A;  1YFM A;  1J3U A;  1GK3 A;  4APA A;  1GKM A;  3C8T A;  2O6Y A;  2HVG A;  1RE5 A;  4ADM A;  1JSW A;  3RD8 A;  4CQ5 A;  2FUS A;  5HW2 A;  1B8F A;  2O78 A;  1HY0 A;  3KDZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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