1KQ7A

E315q mutant form of fumarase c from e.coli
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
sequence length
456
structure length
456
Chain Sequence
VRSEKDSMGAIDVPADKLWGAQTQRSLEHFRISTEKMPTSLIHALALTKRAAAKVNEDLGLLSEEKASAIRQAADEVLAGQHDDEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGVRGMERKVHPNDDVNKSQSSNDVFPTAMHVAALLALRKQLIPQLKTLTQTLNEKSRAFADIVKIGRTHLQDATPLTLGQEISGWVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYARRVADELAVITCAPFVTAPNKFEALATCDALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEISIPENQPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHNFLQSVRLLADGMESFNKHCAVGIEPNRERINQLLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAALALGYLSEAEFDSWVRPEQM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title X-ray crystallographic and kinetic correlation of a clinically observed human fumarase mutation.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Lyase
molecule keywords FUMARATE HYDRATASE CLASS II
total genus 162
structure length 456
sequence length 456
chains with identical sequence B
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2002-01-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 1kq7A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1kq7A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1kq7A02
1T6JA 1GKJA 3R6VA 2O7EA 3NZ4A 4HGVA 4NSLA 3RRPA 1C3UA 3E04A 1FURA 4BABA 2QVEA 1B8FA 3KDYA 1TJUA 4APAA 2O78A 1C3CA 1I0AA 1EB4A 2VD6A 1HY1A 1YFMA 1TJVA 2RJSA 2E9FA 2QGAB 4FLCA 1K62A 1RE5A 4V2RA 2NYFA 1YISA 4V2QA 1DCNA 2O7BA 1GK3A 2NYNA 1GKMA 1XWOA 3R6QA 3NO9A 2FUSA 2OHYA 4ADMA 2PTQA 1T6PA 2RJRA 5F91A 3RD8A 4MX2A 5HW2A 1TJWA 1VDKA 5D6BA 1KQ7A 1AUWA 4C5SA 1GK2A 5EYVA 1YFEA 3CZOA 4C6GA 4ADLA 3KDZA 2O7DA 3OCFA 1FUQA 2PFMA 1Q5NA 4APBA 1FUOA 5EYTA 1W27A 1K7WA 3BHGA 4C5UA 3R6YA 1DOFA 1U15A 2J91A 3GZHA 2X75A 5F92A 2O7FA 1JSWA 1HY0A 4EEIA 3TV2A 1Y2MA 3QBPA 2YIIA 2HVGA 3GTDA 4NLEA 2PTRA 1FUPA 4FFXA 4BAAA 3C8TA 4CQ5A 3OCEA 2O6YA 1J3UA 2PTSA 4EFCA 1U16A 3UNVA 4C5RA 1TJ7A
chains in the Genus database with same CATH superfamily
1T6JA 2VL7A 1MH9A 1GKJA 4A15A 3R6VA 2O7EA 3NZ4A 4HGVA 4NSLA 3RRPA 1C3UA 4IQJM 3E04A 2D27A 1FURA 1Z4LA 4BABA 2QVEA 1B8FA 3KDYA 1TJUA 1XMDA 2RCNA 4APAA 2O78A 1C3CA 1Z4IA 4YIKA 1I0AA 1EB4A 3CRVA 2VD6A 1HY1A 2I7DA 1YFMA 2FELA 1XL7A 1TJVA 1Z4PX 2RJSA 3CRW1 2E9FA 2QGAB 5M0JA 4FLCA 1K62A 1RE5A 1Z4MA 4V2RA 2JAWA 2NYFA 1YISA 4V2QA 1DCNA 2O7BA 1GK3A 2NYNA 1GKMA 1XWOA 3R6QA 1Z4KA 3NO9A 2FUSA 1XMCA 2OHYA 2VSFA 1U0LA 4ADMA 1XL8A 2FENA 2PTQA 1T6PA 2RJRA 5F91A 3RD8A 1T9HA 4MX2A 4L57A 5HW2A 4NFLA 1Q91A 1IW7D 1TJWA 3F4RA 1VDKA 2JAOA 5D6BA 1KQ7A 1AUWA 4C5SA 1GK2A 5EYVA 2JAUA 1YFEA 3CZOA 4C6GA 3F4TA 4ADLA 4L6AA 3KDZA 2O7DA 1Z4JA 3OCFA 4MUMA 3U13A 3F4SA 1Z4QA 1FUQA 2PFMA 1Q5NA 4APBA 4L6CA 3U19A 1FUOA 5EYTA 4WNLA 3CI0K 1W27A 1K7WA 3BHGA 4C5UA 3R6YA 1DOFA 1U15A 2D28C 3BWVA 2J91A 3GZHA 2X75A 4E88A 5F92A 2O7FA 5H8WA 1JSWA 1HY0A 4EEIA 2YV5A 3TV2A 1Y2MA 2JARA 3QBPA 4YIHA 2HVGA 3GTDA 2YIIA 4NLEA 2PTRA 1FUPA 4FFXA 1Q92A 3C8TA 4BAAA 4CQ5A 1XLYA 3OCEA 4MWOA 2O6YA 1J3UA 2PTSA 4EFCA 1U16A 3UNVA 5M0IA 4C5RA 1TJ7A
chains in the Genus database with same CATH topology
1T6JA 1GKJA 3R6VA 2O7EA 3NZ4A 4HGVA 4NSLA 3RRPA 1C3UA 3E04A 1FURA 4BABA 2QVEA 1B8FA 3KDYA 1TJUA 4APAA 2O78A 1C3CA 1I0AA 1EB4A 2VD6A 1HY1A 1YFMA 1TJVA 2RJSA 2E9FA 2QGAB 4FLCA 1K62A 1RE5A 4V2RA 2NYFA 1YISA 4V2QA 1DCNA 2O7BA 1GK3A 2NYNA 1GKMA 1XWOA 3R6QA 3NO9A 2FUSA 2OHYA 4ADMA 2PTQA 1T6PA 2RJRA 5F91A 3RD8A 4MX2A 5HW2A 1TJWA 1VDKA 5D6BA 1KQ7A 1AUWA 4C5SA 1GK2A 5EYVA 1YFEA 3CZOA 4C6GA 4ADLA 3KDZA 2O7DA 3OCFA 1FUQA 2PFMA 1Q5NA 4APBA 1FUOA 5EYTA 1W27A 1K7WA 3BHGA 4C5UA 3R6YA 1DOFA 1U15A 2J91A 3GZHA 2X75A 5F92A 2O7FA 1JSWA 1HY0A 4EEIA 3TV2A 1Y2MA 3QBPA 2YIIA 2HVGA 3GTDA 4NLEA 2PTRA 1FUPA 4FFXA 4BAAA 3C8TA 4CQ5A 3OCEA 2O6YA 1J3UA 2PTSA 4EFCA 1U16A 3UNVA 4C5RA 1TJ7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1T6J A;  1GKJ A;  3R6V A;  2O7E A;  3NZ4 A;  4HGV A;  4NSL A;  3RRP A;  1C3U A;  3E04 A;  1FUR A;  4BAB A;  2QVE A;  1B8F A;  3KDY A;  1TJU A;  4APA A;  2O78 A;  1C3C A;  1I0A A;  1EB4 A;  2VD6 A;  1HY1 A;  1YFM A;  1TJV A;  2RJS A;  2E9F A;  2QGA B;  4FLC A;  1K62 A;  1RE5 A;  4V2R A;  2NYF A;  1YIS A;  4V2Q A;  1DCN A;  2O7B A;  1GK3 A;  2NYN A;  1GKM A;  1XWO A;  3R6Q A;  3NO9 A;  2FUS A;  2OHY A;  4ADM A;  2PTQ A;  1T6P A;  2RJR A;  5F91 A;  3RD8 A;  4MX2 A;  5HW2 A;  1TJW A;  1VDK A;  5D6B A;  1KQ7 A;  1AUW A;  4C5S A;  1GK2 A;  5EYV A;  1YFE A;  3CZO A;  4C6G A;  4ADL A;  3KDZ A;  2O7D A;  3OCF A;  1FUQ A;  2PFM A;  1Q5N A;  4APB A;  1FUO A;  5EYT A;  1W27 A;  1K7W A;  3BHG A;  4C5U A;  3R6Y A;  1DOF A;  1U15 A;  2J91 A;  3GZH A;  2X75 A;  5F92 A;  2O7F A;  1JSW A;  1HY0 A;  4EEI A;  3TV2 A;  1Y2M A;  3QBP A;  2YII A;  2HVG A;  3GTD A;  4NLE A;  2PTR A;  1FUP A;  4FFX A;  4BAA A;  3C8T A;  4CQ5 A;  3OCE A;  2O6Y A;  1J3U A;  2PTS A;  4EFC A;  1U16 A;  3UNV A;  4C5R A;  1TJ7 A; 
#chains in the Genus database with same CATH topology
 1T6J A;  2VL7 A;  1MH9 A;  1GKJ A;  4A15 A;  3R6V A;  2O7E A;  3NZ4 A;  4HGV A;  4NSL A;  3RRP A;  1C3U A;  4IQJ M;  3E04 A;  2D27 A;  1FUR A;  1Z4L A;  4BAB A;  2QVE A;  1B8F A;  3KDY A;  1TJU A;  1XMD A;  2RCN A;  4APA A;  2O78 A;  1C3C A;  1Z4I A;  4YIK A;  1I0A A;  1EB4 A;  3CRV A;  2VD6 A;  1HY1 A;  2I7D A;  1YFM A;  2FEL A;  1XL7 A;  1TJV A;  1Z4P X;  2RJS A;  3CRW 1;  2E9F A;  2QGA B;  5M0J A;  4FLC A;  1K62 A;  1RE5 A;  1Z4M A;  4V2R A;  2JAW A;  2NYF A;  1YIS A;  4V2Q A;  1DCN A;  2O7B A;  1GK3 A;  2NYN A;  1GKM A;  1XWO A;  3R6Q A;  1Z4K A;  3NO9 A;  2FUS A;  1XMC A;  2OHY A;  2VSF A;  1U0L A;  4ADM A;  1XL8 A;  2FEN A;  2PTQ A;  1T6P A;  2RJR A;  5F91 A;  3RD8 A;  1T9H A;  4MX2 A;  4L57 A;  5HW2 A;  4NFL A;  1Q91 A;  1IW7 D;  1TJW A;  3F4R A;  1VDK A;  2JAO A;  5D6B A;  1KQ7 A;  1AUW A;  4C5S A;  1GK2 A;  5EYV A;  2JAU A;  1YFE A;  3CZO A;  4C6G A;  3F4T A;  4ADL A;  4L6A A;  3KDZ A;  2O7D A;  1Z4J A;  3OCF A;  4MUM A;  3U13 A;  3F4S A;  1Z4Q A;  1FUQ A;  2PFM A;  1Q5N A;  4APB A;  4L6C A;  3U19 A;  1FUO A;  5EYT A;  4WNL A;  3CI0 K;  1W27 A;  1K7W A;  3BHG A;  4C5U A;  3R6Y A;  1DOF A;  1U15 A;  2D28 C;  3BWV A;  2J91 A;  3GZH A;  2X75 A;  4E88 A;  5F92 A;  2O7F A;  5H8W A;  1JSW A;  1HY0 A;  4EEI A;  2YV5 A;  3TV2 A;  1Y2M A;  2JAR A;  3QBP A;  4YIH A;  2HVG A;  3GTD A;  2YII A;  4NLE A;  2PTR A;  1FUP A;  4FFX A;  1Q92 A;  3C8T A;  4BAA A;  4CQ5 A;  1XLY A;  3OCE A;  4MWO A;  2O6Y A;  1J3U A;  2PTS A;  4EFC A;  1U16 A;  3UNV A;  5M0I A;  4C5R A;  1TJ7 A; 
#chains in the Genus database with same CATH homology
 1T6J A;  1GKJ A;  3R6V A;  2O7E A;  3NZ4 A;  4HGV A;  4NSL A;  3RRP A;  1C3U A;  3E04 A;  1FUR A;  4BAB A;  2QVE A;  1B8F A;  3KDY A;  1TJU A;  4APA A;  2O78 A;  1C3C A;  1I0A A;  1EB4 A;  2VD6 A;  1HY1 A;  1YFM A;  1TJV A;  2RJS A;  2E9F A;  2QGA B;  4FLC A;  1K62 A;  1RE5 A;  4V2R A;  2NYF A;  1YIS A;  4V2Q A;  1DCN A;  2O7B A;  1GK3 A;  2NYN A;  1GKM A;  1XWO A;  3R6Q A;  3NO9 A;  2FUS A;  2OHY A;  4ADM A;  2PTQ A;  1T6P A;  2RJR A;  5F91 A;  3RD8 A;  4MX2 A;  5HW2 A;  1TJW A;  1VDK A;  5D6B A;  1KQ7 A;  1AUW A;  4C5S A;  1GK2 A;  5EYV A;  1YFE A;  3CZO A;  4C6G A;  4ADL A;  3KDZ A;  2O7D A;  3OCF A;  1FUQ A;  2PFM A;  1Q5N A;  4APB A;  1FUO A;  5EYT A;  1W27 A;  1K7W A;  3BHG A;  4C5U A;  3R6Y A;  1DOF A;  1U15 A;  2J91 A;  3GZH A;  2X75 A;  5F92 A;  2O7F A;  1JSW A;  1HY0 A;  4EEI A;  3TV2 A;  1Y2M A;  3QBP A;  2YII A;  2HVG A;  3GTD A;  4NLE A;  2PTR A;  1FUP A;  4FFX A;  4BAA A;  3C8T A;  4CQ5 A;  3OCE A;  2O6Y A;  1J3U A;  2PTS A;  4EFC A;  1U16 A;  3UNV A;  4C5R A;  1TJ7 A; 
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similar chains in the pdb database (?% sequence similarity)

 
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