1KQ7A

E315q mutant form of fumarase c from e.coli
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
sequence length
456
structure length
456
Chain Sequence
VRSEKDSMGAIDVPADKLWGAQTQRSLEHFRISTEKMPTSLIHALALTKRAAAKVNEDLGLLSEEKASAIRQAADEVLAGQHDDEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGVRGMERKVHPNDDVNKSQSSNDVFPTAMHVAALLALRKQLIPQLKTLTQTLNEKSRAFADIVKIGRTHLQDATPLTLGQEISGWVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYARRVADELAVITCAPFVTAPNKFEALATCDALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEISIPENQPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHNFLQSVRLLADGMESFNKHCAVGIEPNRERINQLLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAALALGYLSEAEFDSWVRPEQM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title X-ray crystallographic and kinetic correlation of a clinically observed human fumarase mutation.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Lyase
molecule keywords FUMARATE HYDRATASE CLASS II
total genus 162
structure length 456
sequence length 456
chains with identical sequence B
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2002-01-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 1kq7A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1kq7A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1kq7A02
1FUOA 1HY1A 4C5RA 1YISA 1GK2A 3C8TA 1XWOA 1TJVA 4V2RA 4BABA 2QGAB 5F91A 1DOFA 2PTSA 5EYTA 1U15A 3GTDA 2E9FA 1C3CA 2FUSA 3R6VA 1FUQA 2OHYA 1Y2MA 1TJWA 1EB4A 1T6JA 5D6BA 1I0AA 2RJSA 2O7FA 3KDYA 1VDKA 1GKMA 1TJUA 2J91A 4FFXA 4HGVA 1FUPA 1GKJA 1KQ7A 3CZOA 1T6PA 3OCFA 1YFEA 1DCNA 1C3UA 2YIIA 2PTRA 4APBA 2O7EA 1JSWA 1HY0A 1B8FA 4V2QA 2PTQA 4C5UA 2HVGA 1K7WA 2X75A 1TJ7A 4APAA 3RD8A 4CQ5A 2O7DA 1YFMA 2VD6A 1GK3A 4C5SA 3KDZA 1RE5A 3NO9A 2NYFA 4EFCA 4ADMA 2O6YA 5F92A 4FLCA 3UNVA 4EEIA 3NZ4A 2NYNA 2RJRA 2O7BA 4ADLA 2PFMA 4BAAA 5HW2A 3OCEA 4MX2A 3TV2A 2O78A 1U16A 1FURA 2QVEA 1Q5NA 3BHGA 5EYVA 4C6GA 3E04A 4NLEA 3R6YA 3GZHA 3RRPA 1AUWA 1J3UA 4NSLA 3QBPA 1K62A 1W27A 3R6QA
chains in the Genus database with same CATH superfamily
4WNLA 1FUOA 1HY1A 4C5RA 1YISA 4E88A 3U19A 1GK2A 1IW7D 3F4SA 3C8TA 1XWOA 3R6QA 1TJVA 4V2RA 4BABA 2QGAB 5F91A 2RCNA 1DOFA 2PTSA 5EYTA 1U15A 3GTDA 2VL7A 2E9FA 1C3CA 4YIHA 2FUSA 3R6VA 1FUQA 3CI0K 2OHYA 2I7DA 4A15A 1Y2MA 1TJWA 1EB4A 3BWVA 3F4TA 2VSFA 2JARA 1T6JA 2JAUA 5D6BA 4L57A 4MWOA 5M0IA 1I0AA 2RJSA 2O7FA 3KDYA 3CRW1 1VDKA 1GKMA 1TJUA 2J91A 4FFXA 4HGVA 5M0JA 2JAWA 1FUPA 1T9HA 1GKJA 1KQ7A 3CZOA 1T6PA 3OCFA 1C3UA 1DCNA 2YIIA 2PTRA 4APBA 1XL8A 2O7EA 1JSWA 1HY0A 2D27A 1B8FA 2PTQA 3F4RA 4V2QA 4C5UA 5H8WA 2HVGA 2JAOA 1K7WA 2X75A 1TJ7A 4APAA 3RD8A 4CQ5A 4YIKA 2O7DA 1Q92A 1Z4IA 1YFMA 4L6CA 2VD6A 1GK3A 3U13A 1Z4JA 4C5SA 3KDZA 1RE5A 1Z4PX 3NO9A 2NYFA 1XMCA 4EFCA 4ADMA 2O6YA 5F92A 4FLCA 3UNVA 4EEIA 3NZ4A 1XMDA 2NYNA 2RJRA 2O7BA 4NFLA 1Z4KA 4MUMA 1Z4LA 4L6AA 4ADLA 2PFMA 4BAAA 1U0LA 5HW2A 2YV5A 3OCEA 1Z4MA 4MX2A 3TV2A 2O78A 4IQJM 1U16A 1FURA 1Z4QA 2QVEA 1Q5NA 3BHGA 5EYVA 2D28C 4C6GA 1XLYA 4NLEA 3E04A 3CRVA 3R6YA 3GZHA 3RRPA 1AUWA 2FENA 1J3UA 1XL7A 2FELA 4NSLA 3QBPA 1K62A 1MH9A 1Q91A 1W27A 1YFEA
chains in the Genus database with same CATH topology
1FUOA 1HY1A 4C5RA 1YISA 1GK2A 3C8TA 1XWOA 1TJVA 4V2RA 4BABA 2QGAB 5F91A 1DOFA 2PTSA 5EYTA 1U15A 3GTDA 2E9FA 1C3CA 2FUSA 3R6VA 1FUQA 2OHYA 1Y2MA 1TJWA 1EB4A 1T6JA 5D6BA 1I0AA 2RJSA 2O7FA 3KDYA 1VDKA 1GKMA 1TJUA 2J91A 4FFXA 4HGVA 1FUPA 1GKJA 1KQ7A 3CZOA 1T6PA 3OCFA 1YFEA 1DCNA 1C3UA 2YIIA 2PTRA 4APBA 2O7EA 1JSWA 1HY0A 1B8FA 4V2QA 2PTQA 4C5UA 2HVGA 1K7WA 2X75A 1TJ7A 4APAA 3RD8A 4CQ5A 2O7DA 1YFMA 2VD6A 1GK3A 4C5SA 3KDZA 1RE5A 3NO9A 2NYFA 4EFCA 4ADMA 2O6YA 5F92A 4FLCA 3UNVA 4EEIA 3NZ4A 2NYNA 2RJRA 2O7BA 4ADLA 2PFMA 4BAAA 5HW2A 3OCEA 4MX2A 3TV2A 2O78A 1U16A 1FURA 2QVEA 1Q5NA 3BHGA 5EYVA 4C6GA 3E04A 4NLEA 3R6YA 3GZHA 3RRPA 1AUWA 1J3UA 4NSLA 3QBPA 1K62A 1W27A 3R6QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FUO A;  1HY1 A;  4C5R A;  1YIS A;  1GK2 A;  3C8T A;  1XWO A;  1TJV A;  4V2R A;  4BAB A;  2QGA B;  5F91 A;  1DOF A;  2PTS A;  5EYT A;  1U15 A;  3GTD A;  2E9F A;  1C3C A;  2FUS A;  3R6V A;  1FUQ A;  2OHY A;  1Y2M A;  1TJW A;  1EB4 A;  1T6J A;  5D6B A;  1I0A A;  2RJS A;  2O7F A;  3KDY A;  1VDK A;  1GKM A;  1TJU A;  2J91 A;  4FFX A;  4HGV A;  1FUP A;  1GKJ A;  1KQ7 A;  3CZO A;  1T6P A;  3OCF A;  1YFE A;  1DCN A;  1C3U A;  2YII A;  2PTR A;  4APB A;  2O7E A;  1JSW A;  1HY0 A;  1B8F A;  4V2Q A;  2PTQ A;  4C5U A;  2HVG A;  1K7W A;  2X75 A;  1TJ7 A;  4APA A;  3RD8 A;  4CQ5 A;  2O7D A;  1YFM A;  2VD6 A;  1GK3 A;  4C5S A;  3KDZ A;  1RE5 A;  3NO9 A;  2NYF A;  4EFC A;  4ADM A;  2O6Y A;  5F92 A;  4FLC A;  3UNV A;  4EEI A;  3NZ4 A;  2NYN A;  2RJR A;  2O7B A;  4ADL A;  2PFM A;  4BAA A;  5HW2 A;  3OCE A;  4MX2 A;  3TV2 A;  2O78 A;  1U16 A;  1FUR A;  2QVE A;  1Q5N A;  3BHG A;  5EYV A;  4C6G A;  3E04 A;  4NLE A;  3R6Y A;  3GZH A;  3RRP A;  1AUW A;  1J3U A;  4NSL A;  3QBP A;  1K62 A;  1W27 A;  3R6Q A; 
#chains in the Genus database with same CATH topology
 4WNL A;  1FUO A;  1HY1 A;  4C5R A;  1YIS A;  4E88 A;  3U19 A;  1GK2 A;  1IW7 D;  3F4S A;  3C8T A;  1XWO A;  3R6Q A;  1TJV A;  4V2R A;  4BAB A;  2QGA B;  5F91 A;  2RCN A;  1DOF A;  2PTS A;  5EYT A;  1U15 A;  3GTD A;  2VL7 A;  2E9F A;  1C3C A;  4YIH A;  2FUS A;  3R6V A;  1FUQ A;  3CI0 K;  2OHY A;  2I7D A;  4A15 A;  1Y2M A;  1TJW A;  1EB4 A;  3BWV A;  3F4T A;  2VSF A;  2JAR A;  1T6J A;  2JAU A;  5D6B A;  4L57 A;  4MWO A;  5M0I A;  1I0A A;  2RJS A;  2O7F A;  3KDY A;  3CRW 1;  1VDK A;  1GKM A;  1TJU A;  2J91 A;  4FFX A;  4HGV A;  5M0J A;  2JAW A;  1FUP A;  1T9H A;  1GKJ A;  1KQ7 A;  3CZO A;  1T6P A;  3OCF A;  1C3U A;  1DCN A;  2YII A;  2PTR A;  4APB A;  1XL8 A;  2O7E A;  1JSW A;  1HY0 A;  2D27 A;  1B8F A;  2PTQ A;  3F4R A;  4V2Q A;  4C5U A;  5H8W A;  2HVG A;  2JAO A;  1K7W A;  2X75 A;  1TJ7 A;  4APA A;  3RD8 A;  4CQ5 A;  4YIK A;  2O7D A;  1Q92 A;  1Z4I A;  1YFM A;  4L6C A;  2VD6 A;  1GK3 A;  3U13 A;  1Z4J A;  4C5S A;  3KDZ A;  1RE5 A;  1Z4P X;  3NO9 A;  2NYF A;  1XMC A;  4EFC A;  4ADM A;  2O6Y A;  5F92 A;  4FLC A;  3UNV A;  4EEI A;  3NZ4 A;  1XMD A;  2NYN A;  2RJR A;  2O7B A;  4NFL A;  1Z4K A;  4MUM A;  1Z4L A;  4L6A A;  4ADL A;  2PFM A;  4BAA A;  1U0L A;  5HW2 A;  2YV5 A;  3OCE A;  1Z4M A;  4MX2 A;  3TV2 A;  2O78 A;  4IQJ M;  1U16 A;  1FUR A;  1Z4Q A;  2QVE A;  1Q5N A;  3BHG A;  5EYV A;  2D28 C;  4C6G A;  1XLY A;  4NLE A;  3E04 A;  3CRV A;  3R6Y A;  3GZH A;  3RRP A;  1AUW A;  2FEN A;  1J3U A;  1XL7 A;  2FEL A;  4NSL A;  3QBP A;  1K62 A;  1MH9 A;  1Q91 A;  1W27 A;  1YFE A; 
#chains in the Genus database with same CATH homology
 1FUO A;  1HY1 A;  4C5R A;  1YIS A;  1GK2 A;  3C8T A;  1XWO A;  1TJV A;  4V2R A;  4BAB A;  2QGA B;  5F91 A;  1DOF A;  2PTS A;  5EYT A;  1U15 A;  3GTD A;  2E9F A;  1C3C A;  2FUS A;  3R6V A;  1FUQ A;  2OHY A;  1Y2M A;  1TJW A;  1EB4 A;  1T6J A;  5D6B A;  1I0A A;  2RJS A;  2O7F A;  3KDY A;  1VDK A;  1GKM A;  1TJU A;  2J91 A;  4FFX A;  4HGV A;  1FUP A;  1GKJ A;  1KQ7 A;  3CZO A;  1T6P A;  3OCF A;  1YFE A;  1DCN A;  1C3U A;  2YII A;  2PTR A;  4APB A;  2O7E A;  1JSW A;  1HY0 A;  1B8F A;  4V2Q A;  2PTQ A;  4C5U A;  2HVG A;  1K7W A;  2X75 A;  1TJ7 A;  4APA A;  3RD8 A;  4CQ5 A;  2O7D A;  1YFM A;  2VD6 A;  1GK3 A;  4C5S A;  3KDZ A;  1RE5 A;  3NO9 A;  2NYF A;  4EFC A;  4ADM A;  2O6Y A;  5F92 A;  4FLC A;  3UNV A;  4EEI A;  3NZ4 A;  2NYN A;  2RJR A;  2O7B A;  4ADL A;  2PFM A;  4BAA A;  5HW2 A;  3OCE A;  4MX2 A;  3TV2 A;  2O78 A;  1U16 A;  1FUR A;  2QVE A;  1Q5N A;  3BHG A;  5EYV A;  4C6G A;  3E04 A;  4NLE A;  3R6Y A;  3GZH A;  3RRP A;  1AUW A;  1J3U A;  4NSL A;  3QBP A;  1K62 A;  1W27 A;  3R6Q A; 
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similar chains in the pdb database (?% sequence similarity)

 
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