4EEIA

Crystal structure of adenylosuccinate lyase from francisella tularensis complexed with amp and succinate
Total Genus 166
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
166
sequence length
433
structure length
414
Chain Sequence
MIKRYDVAEISKIWADENKYAKMLEVELAILEALEDRMVPKGTAAEIRARAQIRPERVDEIEKVTKHDIIAFCTSIAEQFTAETGKFFHFGVTSSDIIDSALSLQIRDSMSYVIKDLEALCDSLLTKAEETKEIITMGRSHGMFAEPMSFGQKFLGAYVEFKRRLKDLKDFQKDGLTVQFSGAVGNYCILTTEDEKKAADILGLPVEEVSTQVIPRDRIAKLISIHGLIASAIERLAVEIRHLHRSDVFEVYEGFKKNPISTENLTGMARMLRSHVSIALENCVLWHERDISHSSAERFYLPDNFGIMVYALRRMKNTIDNLVVQRDIIEDRVRSTSAYLSSFYLHFLVANTPFMREDCYKIVQQVESFSKKLQKVMHDEHNIILDIPEMDFEGIKKTYLKEIDHVFDRSVKAR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lyase
molecule keywords Adenylosuccinate lyase
publication title Crystal Structure of Adenylosuccinate Lyase from Francisella tularensis Complexed with AMP and Succinate
rcsb
source organism Francisella tularensis subsp. tularensis schu s4
total genus 166
structure length 414
sequence length 433
chains with identical sequence B
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 2012-03-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4eeiA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4eeiA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4eeiA02
4HGVA 3KDZA 4V2RA 1Q5NA 1GKJA 1DCNA 1GK2A 2PFMA 3R6YA 3E04A 5D6BA 5EYVA 1FURA 1TJVA 4CQ5A 1FUOA 1YISA 1VDKA 1XWOA 4C5SA 4APAA 1EB4A 4C5RA 4ADLA 2YIIA 1T6JA 2FUSA 1KQ7A 1DOFA 4BAAA 5F91A 3RD8A 3KDYA 2O7FA 2VD6A 2PTSA 2PTQA 1TJ7A 2QGAB 1I0AA 2RJRA 3OCEA 4FFXA 1B8FA 1U15A 3QBPA 4ADMA 3CZOA 2O7DA 2E9FA 1HY1A 1HY0A 1K62A 1C3UA 4V2QA 2O6YA 2NYFA 1FUPA 1K7WA 3NO9A 3C8TA 3NZ4A 3OCFA 5F92A 1C3CA 5HW2A 2RJSA 3UNVA 1GKMA 4FLCA 1T6PA 1TJWA 4C5UA 2O78A 1JSWA 1RE5A 2O7BA 2OHYA 5EYTA 4MX2A 2O7EA 1U16A 2NYNA 1W27A 1YFEA 3RRPA 4BABA 2QVEA 3R6QA 4NSLA 3TV2A 4EFCA 3R6VA 1J3UA 1Y2MA 2HVGA 4APBA 3BHGA 1AUWA 1YFMA 2PTRA 2J91A 1GK3A 1TJUA 1FUQA 4EEIA 3GZHA 2X75A 3GTDA 4C6GA 4NLEA
chains in the Genus database with same CATH superfamily
3F4TA 4HGVA 3CRW1 3KDZA 4V2RA 1Q5NA 4A15A 1GKJA 1DCNA 1GK2A 2PFMA 2JAWA 1MH9A 3E04A 5D6BA 1FURA 1TJVA 5EYVA 3R6YA 4CQ5A 1FUOA 4MWOA 1YISA 1VDKA 1XWOA 1Z4IA 1IW7D 2JAUA 4YIHA 4C5SA 4APAA 1EB4A 4C5RA 4ADLA 4E88A 2YIIA 4IQJM 1T6JA 2FUSA 1KQ7A 1DOFA 1Q92A 4BAAA 4WNLA 5F91A 1Q91A 3RD8A 3KDYA 2O7FA 2VD6A 5M0IA 2PTSA 2PTQA 1TJ7A 2QGAB 1I0AA 2RJRA 3OCEA 2VL7A 4FFXA 1T9HA 1B8FA 1U15A 4YIKA 2JARA 4L57A 3QBPA 4ADMA 3CZOA 2O7DA 1Z4LA 2RCNA 1Z4PX 2E9FA 1HY1A 1Z4JA 1HY0A 2D27A 1K62A 1C3UA 4V2QA 2O6YA 3CI0K 2NYFA 1FUPA 1K7WA 3NO9A 3C8TA 2VSFA 3NZ4A 3OCFA 5M0JA 2I7DA 5F92A 1Z4QA 1C3CA 5HW2A 2FELA 2YV5A 3F4RA 2RJSA 1XL8A 3UNVA 1GKMA 4FLCA 1T6PA 1TJWA 4C5UA 2O78A 1JSWA 2FENA 1RE5A 2O7BA 2OHYA 3CRVA 5EYTA 1Z4MA 1XMCA 4MX2A 2O7EA 5H8WA 1U16A 1XMDA 2NYNA 1W27A 1Z4KA 1XL7A 1YFEA 3RRPA 4BABA 2JAOA 2QVEA 3R6QA 4NSLA 3TV2A 3U13A 4EFCA 3R6VA 4MUMA 1J3UA 1Y2MA 2HVGA 4APBA 3BHGA 3BWVA 1AUWA 1YFMA 4NFLA 2D28C 2PTRA 1U0LA 3F4SA 2J91A 1GK3A 1TJUA 1FUQA 4EEIA 3GZHA 2X75A 3GTDA 1XLYA 3U19A 4L6AA 4L6CA 4C6GA 4NLEA
chains in the Genus database with same CATH topology
4HGVA 3KDZA 4V2RA 1Q5NA 1GKJA 1DCNA 1GK2A 2PFMA 3R6YA 3E04A 5D6BA 5EYVA 1FURA 1TJVA 4CQ5A 1FUOA 1YISA 1VDKA 1XWOA 4C5SA 4APAA 1EB4A 4C5RA 4ADLA 2YIIA 1T6JA 2FUSA 1KQ7A 1DOFA 4BAAA 5F91A 3RD8A 3KDYA 2O7FA 2VD6A 2PTSA 2PTQA 1TJ7A 2QGAB 1I0AA 2RJRA 3OCEA 4FFXA 1B8FA 1U15A 3QBPA 4ADMA 3CZOA 2O7DA 2E9FA 1HY1A 1HY0A 1K62A 1C3UA 4V2QA 2O6YA 2NYFA 1FUPA 1K7WA 3NO9A 3C8TA 3NZ4A 3OCFA 5F92A 1C3CA 5HW2A 2RJSA 3UNVA 1GKMA 4FLCA 1T6PA 1TJWA 4C5UA 2O78A 1JSWA 1RE5A 2O7BA 2OHYA 5EYTA 4MX2A 2O7EA 1U16A 2NYNA 1W27A 1YFEA 3RRPA 4BABA 2QVEA 3R6QA 4NSLA 3TV2A 4EFCA 3R6VA 1J3UA 1Y2MA 2HVGA 4APBA 3BHGA 1AUWA 1YFMA 2PTRA 2J91A 1GK3A 1TJUA 1FUQA 4EEIA 3GZHA 2X75A 3GTDA 4C6GA 4NLEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HGV A;  3KDZ A;  4V2R A;  1Q5N A;  1GKJ A;  1DCN A;  1GK2 A;  2PFM A;  3R6Y A;  3E04 A;  5D6B A;  5EYV A;  1FUR A;  1TJV A;  4CQ5 A;  1FUO A;  1YIS A;  1VDK A;  1XWO A;  4C5S A;  4APA A;  1EB4 A;  4C5R A;  4ADL A;  2YII A;  1T6J A;  2FUS A;  1KQ7 A;  1DOF A;  4BAA A;  5F91 A;  3RD8 A;  3KDY A;  2O7F A;  2VD6 A;  2PTS A;  2PTQ A;  1TJ7 A;  2QGA B;  1I0A A;  2RJR A;  3OCE A;  4FFX A;  1B8F A;  1U15 A;  3QBP A;  4ADM A;  3CZO A;  2O7D A;  2E9F A;  1HY1 A;  1HY0 A;  1K62 A;  1C3U A;  4V2Q A;  2O6Y A;  2NYF A;  1FUP A;  1K7W A;  3NO9 A;  3C8T A;  3NZ4 A;  3OCF A;  5F92 A;  1C3C A;  5HW2 A;  2RJS A;  3UNV A;  1GKM A;  4FLC A;  1T6P A;  1TJW A;  4C5U A;  2O78 A;  1JSW A;  1RE5 A;  2O7B A;  2OHY A;  5EYT A;  4MX2 A;  2O7E A;  1U16 A;  2NYN A;  1W27 A;  1YFE A;  3RRP A;  4BAB A;  2QVE A;  3R6Q A;  4NSL A;  3TV2 A;  4EFC A;  3R6V A;  1J3U A;  1Y2M A;  2HVG A;  4APB A;  3BHG A;  1AUW A;  1YFM A;  2PTR A;  2J91 A;  1GK3 A;  1TJU A;  1FUQ A;  4EEI A;  3GZH A;  2X75 A;  3GTD A;  4C6G A;  4NLE A; 
#chains in the Genus database with same CATH topology
 3F4T A;  4HGV A;  3CRW 1;  3KDZ A;  4V2R A;  1Q5N A;  4A15 A;  1GKJ A;  1DCN A;  1GK2 A;  2PFM A;  2JAW A;  1MH9 A;  3E04 A;  5D6B A;  1FUR A;  1TJV A;  5EYV A;  3R6Y A;  4CQ5 A;  1FUO A;  4MWO A;  1YIS A;  1VDK A;  1XWO A;  1Z4I A;  1IW7 D;  2JAU A;  4YIH A;  4C5S A;  4APA A;  1EB4 A;  4C5R A;  4ADL A;  4E88 A;  2YII A;  4IQJ M;  1T6J A;  2FUS A;  1KQ7 A;  1DOF A;  1Q92 A;  4BAA A;  4WNL A;  5F91 A;  1Q91 A;  3RD8 A;  3KDY A;  2O7F A;  2VD6 A;  5M0I A;  2PTS A;  2PTQ A;  1TJ7 A;  2QGA B;  1I0A A;  2RJR A;  3OCE A;  2VL7 A;  4FFX A;  1T9H A;  1B8F A;  1U15 A;  4YIK A;  2JAR A;  4L57 A;  3QBP A;  4ADM A;  3CZO A;  2O7D A;  1Z4L A;  2RCN A;  1Z4P X;  2E9F A;  1HY1 A;  1Z4J A;  1HY0 A;  2D27 A;  1K62 A;  1C3U A;  4V2Q A;  2O6Y A;  3CI0 K;  2NYF A;  1FUP A;  1K7W A;  3NO9 A;  3C8T A;  2VSF A;  3NZ4 A;  3OCF A;  5M0J A;  2I7D A;  5F92 A;  1Z4Q A;  1C3C A;  5HW2 A;  2FEL A;  2YV5 A;  3F4R A;  2RJS A;  1XL8 A;  3UNV A;  1GKM A;  4FLC A;  1T6P A;  1TJW A;  4C5U A;  2O78 A;  1JSW A;  2FEN A;  1RE5 A;  2O7B A;  2OHY A;  3CRV A;  5EYT A;  1Z4M A;  1XMC A;  4MX2 A;  2O7E A;  5H8W A;  1U16 A;  1XMD A;  2NYN A;  1W27 A;  1Z4K A;  1XL7 A;  1YFE A;  3RRP A;  4BAB A;  2JAO A;  2QVE A;  3R6Q A;  4NSL A;  3TV2 A;  3U13 A;  4EFC A;  3R6V A;  4MUM A;  1J3U A;  1Y2M A;  2HVG A;  4APB A;  3BHG A;  3BWV A;  1AUW A;  1YFM A;  4NFL A;  2D28 C;  2PTR A;  1U0L A;  3F4S A;  2J91 A;  1GK3 A;  1TJU A;  1FUQ A;  4EEI A;  3GZH A;  2X75 A;  3GTD A;  1XLY A;  3U19 A;  4L6A A;  4L6C A;  4C6G A;  4NLE A; 
#chains in the Genus database with same CATH homology
 4HGV A;  3KDZ A;  4V2R A;  1Q5N A;  1GKJ A;  1DCN A;  1GK2 A;  2PFM A;  3R6Y A;  3E04 A;  5D6B A;  5EYV A;  1FUR A;  1TJV A;  4CQ5 A;  1FUO A;  1YIS A;  1VDK A;  1XWO A;  4C5S A;  4APA A;  1EB4 A;  4C5R A;  4ADL A;  2YII A;  1T6J A;  2FUS A;  1KQ7 A;  1DOF A;  4BAA A;  5F91 A;  3RD8 A;  3KDY A;  2O7F A;  2VD6 A;  2PTS A;  2PTQ A;  1TJ7 A;  2QGA B;  1I0A A;  2RJR A;  3OCE A;  4FFX A;  1B8F A;  1U15 A;  3QBP A;  4ADM A;  3CZO A;  2O7D A;  2E9F A;  1HY1 A;  1HY0 A;  1K62 A;  1C3U A;  4V2Q A;  2O6Y A;  2NYF A;  1FUP A;  1K7W A;  3NO9 A;  3C8T A;  3NZ4 A;  3OCF A;  5F92 A;  1C3C A;  5HW2 A;  2RJS A;  3UNV A;  1GKM A;  4FLC A;  1T6P A;  1TJW A;  4C5U A;  2O78 A;  1JSW A;  1RE5 A;  2O7B A;  2OHY A;  5EYT A;  4MX2 A;  2O7E A;  1U16 A;  2NYN A;  1W27 A;  1YFE A;  3RRP A;  4BAB A;  2QVE A;  3R6Q A;  4NSL A;  3TV2 A;  4EFC A;  3R6V A;  1J3U A;  1Y2M A;  2HVG A;  4APB A;  3BHG A;  1AUW A;  1YFM A;  2PTR A;  2J91 A;  1GK3 A;  1TJU A;  1FUQ A;  4EEI A;  3GZH A;  2X75 A;  3GTD A;  4C6G A;  4NLE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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