3RD8A

Crystal structure of fumarate hydratase class ii mycobacterium smegmatis
Total Genus 181
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
181
sequence length
459
structure length
457
Chain Sequence
EYRIEHDTMGEVRVPKDALWRAQTQRAVENFPISFRGLERTQIRALGLLKAACAQVNKDLGLLDPEKADAIIAAAGEIAEGKHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAANGVTVHPNDHVNMSQSSNDTFPTATHIAATEAAVRHLIPALEVLHASLAAKAKQWRTVVKSGRTHLMDAVPVTLGQEFGGYARQIEAGIERVKATLPRLGELAIGGTAVGTGLNAPEGFGAKVVEVLVNETGLAELRTAVDSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVACQVVGNDAAIAFGGASGAFELNVYIPMMARNLLESFTLLSNVSRLFAERCIDGLVANEERLRELAESSPSIVTPLNSAIGYEEAAKVAKQALAEKKTIRQTVIDRGLIGLSLEELDRRLDVLAMARVK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lyase
molecule keywords Fumarate hydratase class II
publication title Increasing the structural coverage of tuberculosis drug targets.
pubmed doi rcsb
source organism Mycobacterium smegmatis
total genus 181
structure length 457
sequence length 459
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2011-04-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 3rd8A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3rd8A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3rd8A02
1U16A 2NYFA 1DOFA 5EYTA 4C6GA 1TJ7A 1YFMA 1KQ7A 3GTDA 3NO9A 3KDZA 3OCEA 1K7WA 1C3UA 5F91A 1FURA 2PFMA 5F92A 4C5RA 2PTRA 1FUOA 1VDKA 3GZHA 2NYNA 2QGAB 5EYVA 4CQ5A 2YIIA 3OCFA 2RJRA 2J91A 2PTQA 1JSWA 3RD8A 4APAA 3R6YA 4MX2A 1Y2MA 1TJVA 4EFCA 1B8FA 2PTSA 4BAAA 2O78A 3KDYA 1EB4A 3QBPA 3C8TA 1FUPA 5HW2A 4FLCA 2O7EA 3RRPA 4BABA 1K62A 1TJUA 4ADMA 1J3UA 5D6BA 1RE5A 2X75A 2QVEA 4ADLA 4C5SA 2RJSA 4APBA 1T6JA 4FFXA 1W27A 4NLEA 1Q5NA 4HGVA 2OHYA 1U15A 4V2QA 1T6PA 1YISA 1C3CA 1TJWA 3TV2A 1AUWA 1YFEA 1GKJA 3R6QA 3E04A 2O7FA 3NZ4A 3BHGA 4NSLA 3CZOA 4EEIA 3UNVA 2E9FA 1GK3A 1XWOA 1GKMA 4C5UA 2HVGA 1HY0A 2O7DA 1FUQA 1HY1A 2O6YA 2FUSA 1I0AA 2O7BA 1GK2A 2VD6A 4V2RA 3R6VA 1DCNA
chains in the Genus database with same CATH superfamily
1U16A 2NYFA 1DOFA 5EYTA 4C6GA 1TJ7A 1YFMA 1KQ7A 3GTDA 3NO9A 3KDZA 1Q91A 3OCEA 1XLYA 1K7WA 1C3UA 5F91A 1FURA 4L57A 4NFLA 2PFMA 5F92A 1XMCA 1Z4KA 4C5RA 2PTRA 1FUOA 1VDKA 3GZHA 2NYNA 2D28C 2QGAB 3BWVA 5EYVA 4CQ5A 2YIIA 2RJRA 2J91A 2PTQA 1JSWA 3RD8A 2VL7A 2I7DA 3U13A 2RCNA 4APAA 3F4TA 3CRW1 1T9HA 3R6YA 2JARA 4MX2A 1Y2MA 1TJVA 4EFCA 1B8FA 2PTSA 4BAAA 2O78A 3KDYA 1EB4A 3QBPA 5M0JA 3C8TA 1FUPA 5HW2A 4FLCA 2O7EA 3CI0K 3RRPA 4BABA 1K62A 3CRVA 1TJUA 1Z4PX 4ADMA 1J3UA 2YV5A 5D6BA 1RE5A 4WNLA 2X75A 2QVEA 4ADLA 4C5SA 1Z4LA 2RJSA 4APBA 1T6JA 4FFXA 2FELA 1W27A 4NLEA 1Q5NA 3F4RA 4HGVA 4MWOA 2OHYA 1U15A 4V2QA 1T6PA 1YISA 1C3CA 1TJWA 3TV2A 1AUWA 1YFEA 1GKJA 3R6QA 3R6VA 2VSFA 3E04A 2O7FA 1Z4IA 3F4SA 3U19A 2JAOA 1Z4MA 3NZ4A 3BHGA 1XL8A 4NSLA 4L6CA 3CZOA 4EEIA 4A15A 3UNVA 2E9FA 1GK3A 1Q92A 1XWOA 4L6AA 1GKMA 4C5UA 2HVGA 1HY0A 2FENA 1Z4JA 1XMDA 2O7DA 2JAUA 1FUQA 4YIKA 1HY1A 2O6YA 2FUSA 5M0IA 4MUMA 2JAWA 1Z4QA 1I0AA 2O7BA 1U0LA 1GK2A 5H8WA 4YIHA 4E88A 2VD6A 1XL7A 1MH9A 2D27A 4V2RA 1IW7D 3OCFA 4IQJM 1DCNA
chains in the Genus database with same CATH topology
1U16A 2NYFA 1DOFA 5EYTA 4C6GA 1TJ7A 1YFMA 1KQ7A 3GTDA 3NO9A 3KDZA 3OCEA 1K7WA 1C3UA 5F91A 1FURA 2PFMA 5F92A 4C5RA 2PTRA 1FUOA 1VDKA 3GZHA 2NYNA 2QGAB 5EYVA 4CQ5A 2YIIA 3OCFA 2RJRA 2J91A 2PTQA 1JSWA 3RD8A 4APAA 3R6YA 4MX2A 1Y2MA 1TJVA 4EFCA 1B8FA 2PTSA 4BAAA 2O78A 3KDYA 1EB4A 3QBPA 3C8TA 1FUPA 5HW2A 4FLCA 2O7EA 3RRPA 4BABA 1K62A 1TJUA 4ADMA 1J3UA 5D6BA 1RE5A 2X75A 2QVEA 4ADLA 4C5SA 2RJSA 4APBA 1T6JA 4FFXA 1W27A 4NLEA 1Q5NA 4HGVA 2OHYA 1U15A 4V2QA 1T6PA 1YISA 1C3CA 1TJWA 3TV2A 1AUWA 1YFEA 1GKJA 3R6QA 3E04A 2O7FA 3NZ4A 3BHGA 4NSLA 3CZOA 4EEIA 3UNVA 2E9FA 1GK3A 1XWOA 1GKMA 4C5UA 2HVGA 1HY0A 2O7DA 1FUQA 1HY1A 2O6YA 2FUSA 1I0AA 2O7BA 1GK2A 2VD6A 4V2RA 3R6VA 1DCNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1U16 A;  2NYF A;  1DOF A;  5EYT A;  4C6G A;  1TJ7 A;  1YFM A;  1KQ7 A;  3GTD A;  3NO9 A;  3KDZ A;  3OCE A;  1K7W A;  1C3U A;  5F91 A;  1FUR A;  2PFM A;  5F92 A;  4C5R A;  2PTR A;  1FUO A;  1VDK A;  3GZH A;  2NYN A;  2QGA B;  5EYV A;  4CQ5 A;  2YII A;  3OCF A;  2RJR A;  2J91 A;  2PTQ A;  1JSW A;  3RD8 A;  4APA A;  3R6Y A;  4MX2 A;  1Y2M A;  1TJV A;  4EFC A;  1B8F A;  2PTS A;  4BAA A;  2O78 A;  3KDY A;  1EB4 A;  3QBP A;  3C8T A;  1FUP A;  5HW2 A;  4FLC A;  2O7E A;  3RRP A;  4BAB A;  1K62 A;  1TJU A;  4ADM A;  1J3U A;  5D6B A;  1RE5 A;  2X75 A;  2QVE A;  4ADL A;  4C5S A;  2RJS A;  4APB A;  1T6J A;  4FFX A;  1W27 A;  4NLE A;  1Q5N A;  4HGV A;  2OHY A;  1U15 A;  4V2Q A;  1T6P A;  1YIS A;  1C3C A;  1TJW A;  3TV2 A;  1AUW A;  1YFE A;  1GKJ A;  3R6Q A;  3E04 A;  2O7F A;  3NZ4 A;  3BHG A;  4NSL A;  3CZO A;  4EEI A;  3UNV A;  2E9F A;  1GK3 A;  1XWO A;  1GKM A;  4C5U A;  2HVG A;  1HY0 A;  2O7D A;  1FUQ A;  1HY1 A;  2O6Y A;  2FUS A;  1I0A A;  2O7B A;  1GK2 A;  2VD6 A;  4V2R A;  3R6V A;  1DCN A; 
#chains in the Genus database with same CATH topology
 1U16 A;  2NYF A;  1DOF A;  5EYT A;  4C6G A;  1TJ7 A;  1YFM A;  1KQ7 A;  3GTD A;  3NO9 A;  3KDZ A;  1Q91 A;  3OCE A;  1XLY A;  1K7W A;  1C3U A;  5F91 A;  1FUR A;  4L57 A;  4NFL A;  2PFM A;  5F92 A;  1XMC A;  1Z4K A;  4C5R A;  2PTR A;  1FUO A;  1VDK A;  3GZH A;  2NYN A;  2D28 C;  2QGA B;  3BWV A;  5EYV A;  4CQ5 A;  2YII A;  2RJR A;  2J91 A;  2PTQ A;  1JSW A;  3RD8 A;  2VL7 A;  2I7D A;  3U13 A;  2RCN A;  4APA A;  3F4T A;  3CRW 1;  1T9H A;  3R6Y A;  2JAR A;  4MX2 A;  1Y2M A;  1TJV A;  4EFC A;  1B8F A;  2PTS A;  4BAA A;  2O78 A;  3KDY A;  1EB4 A;  3QBP A;  5M0J A;  3C8T A;  1FUP A;  5HW2 A;  4FLC A;  2O7E A;  3CI0 K;  3RRP A;  4BAB A;  1K62 A;  3CRV A;  1TJU A;  1Z4P X;  4ADM A;  1J3U A;  2YV5 A;  5D6B A;  1RE5 A;  4WNL A;  2X75 A;  2QVE A;  4ADL A;  4C5S A;  1Z4L A;  2RJS A;  4APB A;  1T6J A;  4FFX A;  2FEL A;  1W27 A;  4NLE A;  1Q5N A;  3F4R A;  4HGV A;  4MWO A;  2OHY A;  1U15 A;  4V2Q A;  1T6P A;  1YIS A;  1C3C A;  1TJW A;  3TV2 A;  1AUW A;  1YFE A;  1GKJ A;  3R6Q A;  3R6V A;  2VSF A;  3E04 A;  2O7F A;  1Z4I A;  3F4S A;  3U19 A;  2JAO A;  1Z4M A;  3NZ4 A;  3BHG A;  1XL8 A;  4NSL A;  4L6C A;  3CZO A;  4EEI A;  4A15 A;  3UNV A;  2E9F A;  1GK3 A;  1Q92 A;  1XWO A;  4L6A A;  1GKM A;  4C5U A;  2HVG A;  1HY0 A;  2FEN A;  1Z4J A;  1XMD A;  2O7D A;  2JAU A;  1FUQ A;  4YIK A;  1HY1 A;  2O6Y A;  2FUS A;  5M0I A;  4MUM A;  2JAW A;  1Z4Q A;  1I0A A;  2O7B A;  1U0L A;  1GK2 A;  5H8W A;  4YIH A;  4E88 A;  2VD6 A;  1XL7 A;  1MH9 A;  2D27 A;  4V2R A;  1IW7 D;  3OCF A;  4IQJ M;  1DCN A; 
#chains in the Genus database with same CATH homology
 1U16 A;  2NYF A;  1DOF A;  5EYT A;  4C6G A;  1TJ7 A;  1YFM A;  1KQ7 A;  3GTD A;  3NO9 A;  3KDZ A;  3OCE A;  1K7W A;  1C3U A;  5F91 A;  1FUR A;  2PFM A;  5F92 A;  4C5R A;  2PTR A;  1FUO A;  1VDK A;  3GZH A;  2NYN A;  2QGA B;  5EYV A;  4CQ5 A;  2YII A;  3OCF A;  2RJR A;  2J91 A;  2PTQ A;  1JSW A;  3RD8 A;  4APA A;  3R6Y A;  4MX2 A;  1Y2M A;  1TJV A;  4EFC A;  1B8F A;  2PTS A;  4BAA A;  2O78 A;  3KDY A;  1EB4 A;  3QBP A;  3C8T A;  1FUP A;  5HW2 A;  4FLC A;  2O7E A;  3RRP A;  4BAB A;  1K62 A;  1TJU A;  4ADM A;  1J3U A;  5D6B A;  1RE5 A;  2X75 A;  2QVE A;  4ADL A;  4C5S A;  2RJS A;  4APB A;  1T6J A;  4FFX A;  1W27 A;  4NLE A;  1Q5N A;  4HGV A;  2OHY A;  1U15 A;  4V2Q A;  1T6P A;  1YIS A;  1C3C A;  1TJW A;  3TV2 A;  1AUW A;  1YFE A;  1GKJ A;  3R6Q A;  3E04 A;  2O7F A;  3NZ4 A;  3BHG A;  4NSL A;  3CZO A;  4EEI A;  3UNV A;  2E9F A;  1GK3 A;  1XWO A;  1GKM A;  4C5U A;  2HVG A;  1HY0 A;  2O7D A;  1FUQ A;  1HY1 A;  2O6Y A;  2FUS A;  1I0A A;  2O7B A;  1GK2 A;  2VD6 A;  4V2R A;  3R6V A;  1DCN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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