3RD8A

Crystal structure of fumarate hydratase class ii mycobacterium smegmatis
Total Genus 181
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
181
sequence length
459
structure length
457
Chain Sequence
b'EYRIEHDTMGEVRVPKDALWRAQTQRAVENFPISFRGLERTQIRALGLLKAACAQVNKDLGLLDPEKADAIIAAAGEIAEGKHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAANGVTVHPNDHVNMSQSSNDTFPTATHIAATEAAVRHLIPALEVLHASLAAKAKQWRTVVKSGRTHLMDAVPVTLGQEFGGYARQIEAGIERVKATLPRLGELAIGGTAVGTGLNAPEGFGAKVVEVLVNETGLAELRTAVDSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVACQVVGNDAAIAFGGASGAFELNVYIPMMARNLLESFTLLSNVSRLFAERCIDGLVANEERLRELAESSPSIVTPLNSAIGYEEAAKVAKQALAEKKTIRQTVIDRGLIGLSLEELDRRLDVLAMARVK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Fumarate hydratase class II
publication title Increasing the structural coverage of tuberculosis drug targets.
pubmed doi rcsb
source organism Mycobacterium smegmatis
molecule tags Lyase
total genus 181
structure length 457
sequence length 459
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2011-04-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 3rd8A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3rd8A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3rd8A02
4HGVA 1FUOA 1YFEA 1GK2A 4C5UA 1DOFA 1YISA 2E9FA 3OCFA 4NSLA 1U15A 3R6VA 1RE5A 2O7EA 1GK3A 2QGAB 1AUWA 4APAA 4ADMA 2VD6A 1KQ7A 3GZHA 4FLCA 3GTDA 2PTRA 1FUQA 1C3CA 1K62A 1Y2MA 1EB4A 1GKJA 2OHYA 4APBA 3R6QA 2O7BA 2O6YA 2RJRA 5D6BA 2O7FA 2NYNA 3E04A 4BAAA 3CZOA 3NO9A 2FUSA 4ADLA 1HY0A 4NLEA 3NZ4A 2X75A 2YIIA 3BHGA 1TJWA 1B8FA 1TJ7A 4BABA 4EFCA 5EYTA 1Q5NA 1W27A 4CQ5A 1T6PA 4C5SA 1GKMA 1VDKA 4V2QA 4FFXA 1TJUA 3TV2A 2PTSA 2O7DA 1TJVA 3KDYA 3KDZA 1YFMA 1C3UA 3RRPA 5EYVA 5F91A 3C8TA 4EEIA 1DCNA 2RJSA 3QBPA 1T6JA 1U16A 1JSWA 4V2RA 2PTQA 1HY1A 5F92A 3RD8A 3R6YA 3OCEA 2O78A 4C5RA 2NYFA 1FURA 1FUPA 4MX2A 4C6GA 3UNVA 1K7WA 2PFMA 1I0AA 2HVGA 5HW2A 1XWOA 2J91A 2QVEA 1J3UA
chains in the Genus database with same CATH superfamily
2JARA 4HGVA 1FUOA 1YFEA 1GK2A 4C5UA 1DOFA 1MH9A 3U13A 1YISA 2JAOA 1Z4MA 2E9FA 3OCFA 3U19A 4NSLA 1U15A 1Z4PX 3R6VA 1RE5A 2O7EA 1GK3A 2QGAB 1AUWA 4APAA 4ADMA 2VD6A 1KQ7A 3GZHA 4FLCA 3GTDA 2PTRA 1FUQA 1C3CA 2D28C 4L57A 1K62A 1Y2MA 1EB4A 1GKJA 2D27A 2OHYA 4L6CA 4APBA 3F4RA 2JAWA 4MWOA 3R6QA 2O7BA 2O6YA 2RJRA 1Z4IA 1Q91A 5D6BA 2O7FA 4L6AA 3F4SA 2FENA 1Z4JA 2NYNA 2VL7A 3E04A 4BAAA 2JAUA 3CZOA 3NO9A 1Z4QA 4WNLA 2FUSA 4NFLA 4ADLA 1HY0A 4NLEA 2RCNA 3NZ4A 2X75A 3BWVA 2YIIA 2VSFA 3BHGA 1TJWA 1B8FA 1TJ7A 4BABA 4E88A 4EFCA 2I7DA 3CRW1 5EYTA 1Q92A 4MUMA 1XMDA 1Q5NA 1W27A 4CQ5A 1T6PA 4C5SA 1GKMA 4YIKA 1VDKA 4V2QA 4FFXA 1TJUA 3TV2A 2PTSA 2O7DA 1T9HA 1TJVA 4A15A 3KDYA 3KDZA 1YFMA 1C3UA 1XLYA 1XL8A 3RRPA 5EYVA 5H8WA 5F91A 3C8TA 1IW7D 5M0IA 4EEIA 1DCNA 2RJSA 3QBPA 1XMCA 1T6JA 1U16A 1JSWA 1XL7A 4V2RA 2PTQA 2FELA 1HY1A 2YV5A 5F92A 3RD8A 3R6YA 4IQJM 3OCEA 5M0JA 1Z4KA 2O78A 4C5RA 2NYFA 1FURA 3CRVA 1FUPA 4MX2A 4C6GA 1Z4LA 3CI0K 3UNVA 1K7WA 2PFMA 4YIHA 1I0AA 2HVGA 3F4TA 5HW2A 1XWOA 1U0LA 2J91A 2QVEA 1J3UA
chains in the Genus database with same CATH topology
4HGVA 1FUOA 1YFEA 1GK2A 4C5UA 1DOFA 1YISA 2E9FA 3OCFA 4NSLA 1U15A 3R6VA 1RE5A 2O7EA 1GK3A 2QGAB 1AUWA 4APAA 4ADMA 2VD6A 1KQ7A 3GZHA 4FLCA 3GTDA 2PTRA 1FUQA 1C3CA 1K62A 1Y2MA 1EB4A 1GKJA 2OHYA 4APBA 3R6QA 2O7BA 2O6YA 2RJRA 5D6BA 2O7FA 2NYNA 3E04A 4BAAA 3CZOA 3NO9A 2FUSA 4ADLA 1HY0A 4NLEA 3NZ4A 2X75A 2YIIA 3BHGA 1TJWA 1B8FA 1TJ7A 4BABA 4EFCA 5EYTA 1Q5NA 1W27A 4CQ5A 1T6PA 4C5SA 1GKMA 1VDKA 4V2QA 4FFXA 1TJUA 3TV2A 2PTSA 2O7DA 1TJVA 3KDYA 3KDZA 1YFMA 1C3UA 3RRPA 5EYVA 5F91A 3C8TA 4EEIA 1DCNA 2RJSA 3QBPA 1T6JA 1U16A 1JSWA 4V2RA 2PTQA 1HY1A 5F92A 3RD8A 3R6YA 3OCEA 2O78A 4C5RA 2NYFA 1FURA 1FUPA 4MX2A 4C6GA 3UNVA 1K7WA 2PFMA 1I0AA 2HVGA 5HW2A 1XWOA 2J91A 2QVEA 1J3UA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HGV A;  1FUO A;  1YFE A;  1GK2 A;  4C5U A;  1DOF A;  1YIS A;  2E9F A;  3OCF A;  4NSL A;  1U15 A;  3R6V A;  1RE5 A;  2O7E A;  1GK3 A;  2QGA B;  1AUW A;  4APA A;  4ADM A;  2VD6 A;  1KQ7 A;  3GZH A;  4FLC A;  3GTD A;  2PTR A;  1FUQ A;  1C3C A;  1K62 A;  1Y2M A;  1EB4 A;  1GKJ A;  2OHY A;  4APB A;  3R6Q A;  2O7B A;  2O6Y A;  2RJR A;  5D6B A;  2O7F A;  2NYN A;  3E04 A;  4BAA A;  3CZO A;  3NO9 A;  2FUS A;  4ADL A;  1HY0 A;  4NLE A;  3NZ4 A;  2X75 A;  2YII A;  3BHG A;  1TJW A;  1B8F A;  1TJ7 A;  4BAB A;  4EFC A;  5EYT A;  1Q5N A;  1W27 A;  4CQ5 A;  1T6P A;  4C5S A;  1GKM A;  1VDK A;  4V2Q A;  4FFX A;  1TJU A;  3TV2 A;  2PTS A;  2O7D A;  1TJV A;  3KDY A;  3KDZ A;  1YFM A;  1C3U A;  3RRP A;  5EYV A;  5F91 A;  3C8T A;  4EEI A;  1DCN A;  2RJS A;  3QBP A;  1T6J A;  1U16 A;  1JSW A;  4V2R A;  2PTQ A;  1HY1 A;  5F92 A;  3RD8 A;  3R6Y A;  3OCE A;  2O78 A;  4C5R A;  2NYF A;  1FUR A;  1FUP A;  4MX2 A;  4C6G A;  3UNV A;  1K7W A;  2PFM A;  1I0A A;  2HVG A;  5HW2 A;  1XWO A;  2J91 A;  2QVE A;  1J3U A; 
#chains in the Genus database with same CATH topology
 2JAR A;  4HGV A;  1FUO A;  1YFE A;  1GK2 A;  4C5U A;  1DOF A;  1MH9 A;  3U13 A;  1YIS A;  2JAO A;  1Z4M A;  2E9F A;  3OCF A;  3U19 A;  4NSL A;  1U15 A;  1Z4P X;  3R6V A;  1RE5 A;  2O7E A;  1GK3 A;  2QGA B;  1AUW A;  4APA A;  4ADM A;  2VD6 A;  1KQ7 A;  3GZH A;  4FLC A;  3GTD A;  2PTR A;  1FUQ A;  1C3C A;  2D28 C;  4L57 A;  1K62 A;  1Y2M A;  1EB4 A;  1GKJ A;  2D27 A;  2OHY A;  4L6C A;  4APB A;  3F4R A;  2JAW A;  4MWO A;  3R6Q A;  2O7B A;  2O6Y A;  2RJR A;  1Z4I A;  1Q91 A;  5D6B A;  2O7F A;  4L6A A;  3F4S A;  2FEN A;  1Z4J A;  2NYN A;  2VL7 A;  3E04 A;  4BAA A;  2JAU A;  3CZO A;  3NO9 A;  1Z4Q A;  4WNL A;  2FUS A;  4NFL A;  4ADL A;  1HY0 A;  4NLE A;  2RCN A;  3NZ4 A;  2X75 A;  3BWV A;  2YII A;  2VSF A;  3BHG A;  1TJW A;  1B8F A;  1TJ7 A;  4BAB A;  4E88 A;  4EFC A;  2I7D A;  3CRW 1;  5EYT A;  1Q92 A;  4MUM A;  1XMD A;  1Q5N A;  1W27 A;  4CQ5 A;  1T6P A;  4C5S A;  1GKM A;  4YIK A;  1VDK A;  4V2Q A;  4FFX A;  1TJU A;  3TV2 A;  2PTS A;  2O7D A;  1T9H A;  1TJV A;  4A15 A;  3KDY A;  3KDZ A;  1YFM A;  1C3U A;  1XLY A;  1XL8 A;  3RRP A;  5EYV A;  5H8W A;  5F91 A;  3C8T A;  1IW7 D;  5M0I A;  4EEI A;  1DCN A;  2RJS A;  3QBP A;  1XMC A;  1T6J A;  1U16 A;  1JSW A;  1XL7 A;  4V2R A;  2PTQ A;  2FEL A;  1HY1 A;  2YV5 A;  5F92 A;  3RD8 A;  3R6Y A;  4IQJ M;  3OCE A;  5M0J A;  1Z4K A;  2O78 A;  4C5R A;  2NYF A;  1FUR A;  3CRV A;  1FUP A;  4MX2 A;  4C6G A;  1Z4L A;  3CI0 K;  3UNV A;  1K7W A;  2PFM A;  4YIH A;  1I0A A;  2HVG A;  3F4T A;  5HW2 A;  1XWO A;  1U0L A;  2J91 A;  2QVE A;  1J3U A; 
#chains in the Genus database with same CATH homology
 4HGV A;  1FUO A;  1YFE A;  1GK2 A;  4C5U A;  1DOF A;  1YIS A;  2E9F A;  3OCF A;  4NSL A;  1U15 A;  3R6V A;  1RE5 A;  2O7E A;  1GK3 A;  2QGA B;  1AUW A;  4APA A;  4ADM A;  2VD6 A;  1KQ7 A;  3GZH A;  4FLC A;  3GTD A;  2PTR A;  1FUQ A;  1C3C A;  1K62 A;  1Y2M A;  1EB4 A;  1GKJ A;  2OHY A;  4APB A;  3R6Q A;  2O7B A;  2O6Y A;  2RJR A;  5D6B A;  2O7F A;  2NYN A;  3E04 A;  4BAA A;  3CZO A;  3NO9 A;  2FUS A;  4ADL A;  1HY0 A;  4NLE A;  3NZ4 A;  2X75 A;  2YII A;  3BHG A;  1TJW A;  1B8F A;  1TJ7 A;  4BAB A;  4EFC A;  5EYT A;  1Q5N A;  1W27 A;  4CQ5 A;  1T6P A;  4C5S A;  1GKM A;  1VDK A;  4V2Q A;  4FFX A;  1TJU A;  3TV2 A;  2PTS A;  2O7D A;  1TJV A;  3KDY A;  3KDZ A;  1YFM A;  1C3U A;  3RRP A;  5EYV A;  5F91 A;  3C8T A;  4EEI A;  1DCN A;  2RJS A;  3QBP A;  1T6J A;  1U16 A;  1JSW A;  4V2R A;  2PTQ A;  1HY1 A;  5F92 A;  3RD8 A;  3R6Y A;  3OCE A;  2O78 A;  4C5R A;  2NYF A;  1FUR A;  1FUP A;  4MX2 A;  4C6G A;  3UNV A;  1K7W A;  2PFM A;  1I0A A;  2HVG A;  5HW2 A;  1XWO A;  2J91 A;  2QVE A;  1J3U A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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