1FUQA

Fumarase with bound 3-trimethylsilylsuccinic acid
Total Genus 171
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
171
sequence length
456
structure length
456
Chain Sequence
VRSEKDSMGAIDVPADKLWGAQTQRSLEHFRISTEKMPTSLIHALALTKRAAAKVNEDLGLLSEEKASAIRQAADEVLAGQHDDEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGVRGMERKVHPNDDVNKSQSSNDVFPTAMHVAALLALRKQLIPQLKTLTQTLNEKSRAFADIVKIGRTHLQDATPLTLGQEISGWVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYARRVADELAVITCAPFVTAPNKFEALATCDALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEISIPENEPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHNFLQSVRLLADGMESFNKHCAVGIEPNRERINQLLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAALALGYLSEAEFDSWVRPEQM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords FUMARASE C
publication title Crystallographic studies of the catalytic and a second site in fumarase C from Escherichia coli.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Lyase
total genus 171
structure length 456
sequence length 456
chains with identical sequence B
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 1996-08-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 1fuqA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1fuqA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1fuqA02
2NYNA 2O78A 1C3UA 1YFEA 3R6QA 3R6YA 1EB4A 2NYFA 2RJSA 1HY0A 2PTRA 3UNVA 2PTQA 1FUQA 1FURA 4BAAA 4EFCA 1T6JA 3NZ4A 2J91A 3OCFA 1W27A 1RE5A 1TJUA 1GK3A 1KQ7A 2YIIA 1Q5NA 3R6VA 1Y2MA 3KDYA 5F92A 1JSWA 3C8TA 2QVEA 3RD8A 1AUWA 1GKMA 4C6GA 2QGAB 1J3UA 1TJVA 3GTDA 1K7WA 2RJRA 4V2RA 1GKJA 4HGVA 1U16A 1K62A 5EYTA 4ADMA 2O7BA 4C5RA 3CZOA 1XWOA 5EYVA 4EEIA 3BHGA 3TV2A 3NO9A 2O7EA 2O6YA 4FLCA 2X75A 1FUOA 2OHYA 4C5SA 1DOFA 1YISA 4ADLA 4BABA 1B8FA 2HVGA 1TJ7A 5F91A 5HW2A 2O7DA 1FUPA 2PTSA 2PFMA 3E04A 3QBPA 3GZHA 1C3CA 2FUSA 4NLEA 1HY1A 3OCEA 3KDZA 1VDKA 1DCNA 1TJWA 1U15A 1GK2A 4FFXA 1I0AA 1T6PA 4V2QA 4MX2A 4APAA 2E9FA 2O7FA 3RRPA 2VD6A 4NSLA 4C5UA 4CQ5A 1YFMA 5D6BA 4APBA
chains in the Genus database with same CATH superfamily
5M0JA 2NYNA 2O78A 1C3UA 2VL7A 1YFEA 3R6QA 3R6YA 1EB4A 2NYFA 4L57A 1XMDA 2RJSA 1HY0A 2PTRA 4WNLA 1Z4IA 3UNVA 1MH9A 2PTQA 1FUQA 4YIKA 2JARA 1FURA 4BAAA 4EFCA 4MUMA 1T6JA 3NZ4A 2J91A 3OCFA 1W27A 1RE5A 1Z4MA 1Z4KA 1TJUA 1GK3A 1KQ7A 2YIIA 1Q5NA 2JAOA 3R6VA 1Q92A 2RCNA 3F4TA 1Y2MA 3KDYA 1Z4QA 4MWOA 5F92A 2JAWA 1JSWA 3C8TA 3F4SA 3U13A 2QVEA 3RD8A 1AUWA 2D28C 1GKMA 4C6GA 3BWVA 1Z4LA 2QGAB 1J3UA 3GTDA 1TJVA 1K7WA 2RJRA 1IW7D 4V2RA 1GKJA 4HGVA 1U16A 4IQJM 1K62A 5EYTA 1Z4JA 4ADMA 2O7BA 4C5RA 3CI0K 3CZOA 2FENA 4A15A 1XWOA 5EYVA 4EEIA 1Q91A 3BHGA 3TV2A 3NO9A 2O7EA 2I7DA 1XL8A 2O6YA 4NFLA 4FLCA 4L6CA 2X75A 1T9HA 5M0IA 1FUOA 1U0LA 1Z4PX 2OHYA 4C5SA 1DOFA 2D27A 4ADLA 1XL7A 1YISA 4BABA 1B8FA 2JAUA 1XMCA 2HVGA 1TJ7A 4YIHA 5F91A 5HW2A 2O7DA 3CRW1 1FUPA 2VSFA 3F4RA 2YV5A 2PTSA 2PFMA 3E04A 3QBPA 3GZHA 1C3CA 1XLYA 2FUSA 4NLEA 1HY1A 3U19A 3OCEA 3KDZA 4L6AA 5H8WA 1VDKA 1DCNA 1TJWA 1U15A 1GK2A 4FFXA 1I0AA 1T6PA 4V2QA 4MX2A 4APAA 2E9FA 2O7FA 3RRPA 2FELA 2VD6A 4NSLA 3CRVA 4C5UA 4CQ5A 4E88A 1YFMA 5D6BA 4APBA
chains in the Genus database with same CATH topology
2NYNA 2O78A 1C3UA 1YFEA 3R6QA 3R6YA 1EB4A 2NYFA 2RJSA 1HY0A 2PTRA 3UNVA 2PTQA 1FUQA 1FURA 4BAAA 4EFCA 1T6JA 3NZ4A 2J91A 3OCFA 1W27A 1RE5A 1TJUA 1GK3A 1KQ7A 2YIIA 1Q5NA 3R6VA 1Y2MA 3KDYA 5F92A 1JSWA 3C8TA 2QVEA 3RD8A 1AUWA 1GKMA 4C6GA 2QGAB 1J3UA 1TJVA 3GTDA 1K7WA 2RJRA 4V2RA 1GKJA 4HGVA 1U16A 1K62A 5EYTA 4ADMA 2O7BA 4C5RA 3CZOA 1XWOA 5EYVA 4EEIA 3BHGA 3TV2A 3NO9A 2O7EA 2O6YA 4FLCA 2X75A 1FUOA 2OHYA 4C5SA 1DOFA 1YISA 4ADLA 4BABA 1B8FA 2HVGA 1TJ7A 5F91A 5HW2A 2O7DA 1FUPA 2PTSA 2PFMA 3E04A 3QBPA 3GZHA 1C3CA 2FUSA 4NLEA 1HY1A 3OCEA 3KDZA 1VDKA 1DCNA 1TJWA 1U15A 1GK2A 4FFXA 1I0AA 1T6PA 4V2QA 4MX2A 4APAA 2E9FA 2O7FA 3RRPA 2VD6A 4NSLA 4C5UA 4CQ5A 1YFMA 5D6BA 4APBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NYN A;  2O78 A;  1C3U A;  1YFE A;  3R6Q A;  3R6Y A;  1EB4 A;  2NYF A;  2RJS A;  1HY0 A;  2PTR A;  3UNV A;  2PTQ A;  1FUQ A;  1FUR A;  4BAA A;  4EFC A;  1T6J A;  3NZ4 A;  2J91 A;  3OCF A;  1W27 A;  1RE5 A;  1TJU A;  1GK3 A;  1KQ7 A;  2YII A;  1Q5N A;  3R6V A;  1Y2M A;  3KDY A;  5F92 A;  1JSW A;  3C8T A;  2QVE A;  3RD8 A;  1AUW A;  1GKM A;  4C6G A;  2QGA B;  1J3U A;  1TJV A;  3GTD A;  1K7W A;  2RJR A;  4V2R A;  1GKJ A;  4HGV A;  1U16 A;  1K62 A;  5EYT A;  4ADM A;  2O7B A;  4C5R A;  3CZO A;  1XWO A;  5EYV A;  4EEI A;  3BHG A;  3TV2 A;  3NO9 A;  2O7E A;  2O6Y A;  4FLC A;  2X75 A;  1FUO A;  2OHY A;  4C5S A;  1DOF A;  1YIS A;  4ADL A;  4BAB A;  1B8F A;  2HVG A;  1TJ7 A;  5F91 A;  5HW2 A;  2O7D A;  1FUP A;  2PTS A;  2PFM A;  3E04 A;  3QBP A;  3GZH A;  1C3C A;  2FUS A;  4NLE A;  1HY1 A;  3OCE A;  3KDZ A;  1VDK A;  1DCN A;  1TJW A;  1U15 A;  1GK2 A;  4FFX A;  1I0A A;  1T6P A;  4V2Q A;  4MX2 A;  4APA A;  2E9F A;  2O7F A;  3RRP A;  2VD6 A;  4NSL A;  4C5U A;  4CQ5 A;  1YFM A;  5D6B A;  4APB A; 
#chains in the Genus database with same CATH topology
 5M0J A;  2NYN A;  2O78 A;  1C3U A;  2VL7 A;  1YFE A;  3R6Q A;  3R6Y A;  1EB4 A;  2NYF A;  4L57 A;  1XMD A;  2RJS A;  1HY0 A;  2PTR A;  4WNL A;  1Z4I A;  3UNV A;  1MH9 A;  2PTQ A;  1FUQ A;  4YIK A;  2JAR A;  1FUR A;  4BAA A;  4EFC A;  4MUM A;  1T6J A;  3NZ4 A;  2J91 A;  3OCF A;  1W27 A;  1RE5 A;  1Z4M A;  1Z4K A;  1TJU A;  1GK3 A;  1KQ7 A;  2YII A;  1Q5N A;  2JAO A;  3R6V A;  1Q92 A;  2RCN A;  3F4T A;  1Y2M A;  3KDY A;  1Z4Q A;  4MWO A;  5F92 A;  2JAW A;  1JSW A;  3C8T A;  3F4S A;  3U13 A;  2QVE A;  3RD8 A;  1AUW A;  2D28 C;  1GKM A;  4C6G A;  3BWV A;  1Z4L A;  2QGA B;  1J3U A;  3GTD A;  1TJV A;  1K7W A;  2RJR A;  1IW7 D;  4V2R A;  1GKJ A;  4HGV A;  1U16 A;  4IQJ M;  1K62 A;  5EYT A;  1Z4J A;  4ADM A;  2O7B A;  4C5R A;  3CI0 K;  3CZO A;  2FEN A;  4A15 A;  1XWO A;  5EYV A;  4EEI A;  1Q91 A;  3BHG A;  3TV2 A;  3NO9 A;  2O7E A;  2I7D A;  1XL8 A;  2O6Y A;  4NFL A;  4FLC A;  4L6C A;  2X75 A;  1T9H A;  5M0I A;  1FUO A;  1U0L A;  1Z4P X;  2OHY A;  4C5S A;  1DOF A;  2D27 A;  4ADL A;  1XL7 A;  1YIS A;  4BAB A;  1B8F A;  2JAU A;  1XMC A;  2HVG A;  1TJ7 A;  4YIH A;  5F91 A;  5HW2 A;  2O7D A;  3CRW 1;  1FUP A;  2VSF A;  3F4R A;  2YV5 A;  2PTS A;  2PFM A;  3E04 A;  3QBP A;  3GZH A;  1C3C A;  1XLY A;  2FUS A;  4NLE A;  1HY1 A;  3U19 A;  3OCE A;  3KDZ A;  4L6A A;  5H8W A;  1VDK A;  1DCN A;  1TJW A;  1U15 A;  1GK2 A;  4FFX A;  1I0A A;  1T6P A;  4V2Q A;  4MX2 A;  4APA A;  2E9F A;  2O7F A;  3RRP A;  2FEL A;  2VD6 A;  4NSL A;  3CRV A;  4C5U A;  4CQ5 A;  4E88 A;  1YFM A;  5D6B A;  4APB A; 
#chains in the Genus database with same CATH homology
 2NYN A;  2O78 A;  1C3U A;  1YFE A;  3R6Q A;  3R6Y A;  1EB4 A;  2NYF A;  2RJS A;  1HY0 A;  2PTR A;  3UNV A;  2PTQ A;  1FUQ A;  1FUR A;  4BAA A;  4EFC A;  1T6J A;  3NZ4 A;  2J91 A;  3OCF A;  1W27 A;  1RE5 A;  1TJU A;  1GK3 A;  1KQ7 A;  2YII A;  1Q5N A;  3R6V A;  1Y2M A;  3KDY A;  5F92 A;  1JSW A;  3C8T A;  2QVE A;  3RD8 A;  1AUW A;  1GKM A;  4C6G A;  2QGA B;  1J3U A;  1TJV A;  3GTD A;  1K7W A;  2RJR A;  4V2R A;  1GKJ A;  4HGV A;  1U16 A;  1K62 A;  5EYT A;  4ADM A;  2O7B A;  4C5R A;  3CZO A;  1XWO A;  5EYV A;  4EEI A;  3BHG A;  3TV2 A;  3NO9 A;  2O7E A;  2O6Y A;  4FLC A;  2X75 A;  1FUO A;  2OHY A;  4C5S A;  1DOF A;  1YIS A;  4ADL A;  4BAB A;  1B8F A;  2HVG A;  1TJ7 A;  5F91 A;  5HW2 A;  2O7D A;  1FUP A;  2PTS A;  2PFM A;  3E04 A;  3QBP A;  3GZH A;  1C3C A;  2FUS A;  4NLE A;  1HY1 A;  3OCE A;  3KDZ A;  1VDK A;  1DCN A;  1TJW A;  1U15 A;  1GK2 A;  4FFX A;  1I0A A;  1T6P A;  4V2Q A;  4MX2 A;  4APA A;  2E9F A;  2O7F A;  3RRP A;  2VD6 A;  4NSL A;  4C5U A;  4CQ5 A;  1YFM A;  5D6B A;  4APB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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