5HW2A

Crystal structure of adenylosuccinate lyase from francisella tularensis complexed with fumaric acid
Total Genus 147
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
147
sequence length
438
structure length
419
Chain Sequence
MIKRYDVAEISKIWADENKYAKMLEVELAILEALEDRMVPKGTAAEIRARAQIRPERVDEIEKVTKHDIIAFCTSIAEQFTAETGKFFHFGVTSSDIIDSALSLQIRDSMSYVIKDLEALCDSLLTKAEETKEIITMGRSHGMFAEPMSFGQKFLGAYVEFKRRLKDLKDFQKDGLTVQFSGAVGNYCILTTEDEKKAADILGLPVEEVSTQVIPRDRIAKLISIHGLIASAIERLAVEIRHLHRSDVFEVYEGFKKNPISTENLTGMARMLRSHVSIALENCVLWHERDISHSSAERFYLPDNFGIMVYALRRMKNTIDNLVVQRDIIEDRVRSTSAYLSSFYLHFLVANTPFMREDCYKIVQQVESFSKKLQKVMHDEHNIILDIPEMDFEGIKKTYLKEIDHVFDRSVKARGENLY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lyase
molecule keywords Adenylosuccinate lyase
publication title Crystal Structure of Adenylosuccinate Lyase from Francisella tularensis Complexed with fumaric acid
rcsb
source organism Francisella tularensis subsp. tularensis (strain schu s4 / schu 4)
total genus 147
structure length 419
sequence length 438
chains with identical sequence B, C, D
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 2016-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 5hw2A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 5hw2A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 5hw2A02
1C3UA 2PFMA 3GTDA 1U15A 4EEIA 3RRPA 3OCEA 1YFEA 1Q5NA 1I0AA 2E9FA 1T6JA 3UNVA 3KDZA 1K7WA 1GKJA 2RJRA 4APBA 2OHYA 2PTQA 1FUQA 1FURA 4NLEA 4C5SA 4MX2A 2O7BA 3CZOA 1DOFA 2FUSA 1YISA 1VDKA 4FFXA 2PTSA 3OCFA 5EYVA 1YFMA 2J91A 2O6YA 1XWOA 3NZ4A 4V2QA 4CQ5A 3R6YA 5EYTA 1J3UA 2HVGA 3TV2A 1TJVA 3C8TA 1TJUA 1T6PA 5F91A 1DCNA 1Y2MA 4EFCA 1TJWA 3BHGA 4ADMA 2O7DA 4BABA 1KQ7A 2VD6A 4ADLA 1TJ7A 1RE5A 1FUPA 1JSWA 1K62A 5D6BA 2O78A 4BAAA 2PTRA 3RD8A 4C5RA 4C6GA 1U16A 2YIIA 5F92A 1GKMA 3R6QA 4APAA 5HW2A 4NSLA 3NO9A 1B8FA 4HGVA 3GZHA 1C3CA 3E04A 2O7EA 2QGAB 1FUOA 2X75A 1GK3A 3KDYA 4FLCA 1HY0A 3QBPA 1AUWA 2NYNA 1HY1A 4V2RA 1GK2A 4C5UA 2QVEA 3R6VA 2RJSA 2O7FA 1EB4A 1W27A 2NYFA
chains in the Genus database with same CATH superfamily
1C3UA 3CRW1 2PFMA 3GTDA 1U15A 4EEIA 2RCNA 3RRPA 3OCEA 1YFEA 1XMCA 1Q5NA 1I0AA 2E9FA 1T6JA 3UNVA 3KDZA 1K7WA 3CI0K 1GKJA 4IQJM 2RJRA 5M0IA 2D27A 4APBA 2OHYA 1Z4JA 2PTQA 1FUQA 1Q91A 1FURA 4NLEA 4C5SA 4MX2A 2O7BA 3CZOA 1DOFA 2FUSA 1YISA 1VDKA 4FFXA 5H8WA 2PTSA 3CRVA 3OCFA 5EYVA 1YFMA 1IW7D 2J91A 2O6YA 1XWOA 3NZ4A 4V2QA 4CQ5A 3R6YA 4NFLA 5EYTA 1J3UA 3F4RA 2HVGA 4YIKA 3TV2A 4MWOA 1TJVA 3C8TA 1TJUA 1U0LA 1T6PA 5F91A 2FELA 4MUMA 1DCNA 4L6CA 1Y2MA 4EFCA 1TJWA 3BHGA 3F4TA 3U19A 4ADMA 1XL8A 2O7DA 5M0JA 4BABA 1KQ7A 2VD6A 1TJ7A 4ADLA 4WNLA 1RE5A 1FUPA 1JSWA 1K62A 5D6BA 2O78A 1Q92A 4BAAA 4A15A 1XL7A 4L6AA 2PTRA 3RD8A 2VL7A 4C5RA 2JARA 1XLYA 2JAUA 4C6GA 1U16A 1Z4LA 2YIIA 5F92A 1GKMA 1Z4KA 3R6QA 4APAA 5HW2A 4NSLA 3NO9A 1MH9A 1B8FA 1W27A 2YV5A 3BWVA 4HGVA 3GZHA 1C3CA 3E04A 2O7EA 2QGAB 3U13A 2FENA 1Z4QA 1Z4IA 1Z4PX 1FUOA 1T9HA 4L57A 2X75A 1GK3A 3KDYA 2JAWA 4FLCA 1HY0A 4YIHA 3QBPA 1Z4MA 1AUWA 2NYNA 1HY1A 3F4SA 4V2RA 1GK2A 4C5UA 2VSFA 2QVEA 2JAOA 3R6VA 2RJSA 2D28C 4E88A 2O7FA 1EB4A 2I7DA 1XMDA 2NYFA
chains in the Genus database with same CATH topology
1C3UA 2PFMA 3GTDA 1U15A 4EEIA 3RRPA 3OCEA 1YFEA 1Q5NA 1I0AA 2E9FA 1T6JA 3UNVA 3KDZA 1K7WA 1GKJA 2RJRA 4APBA 2OHYA 2PTQA 1FUQA 1FURA 4NLEA 4C5SA 4MX2A 2O7BA 3CZOA 1DOFA 2FUSA 1YISA 1VDKA 4FFXA 2PTSA 3OCFA 5EYVA 1YFMA 2J91A 2O6YA 1XWOA 3NZ4A 4V2QA 4CQ5A 3R6YA 5EYTA 1J3UA 2HVGA 3TV2A 1TJVA 3C8TA 1TJUA 1T6PA 5F91A 1DCNA 1Y2MA 4EFCA 1TJWA 3BHGA 4ADMA 2O7DA 4BABA 1KQ7A 2VD6A 4ADLA 1TJ7A 1RE5A 1FUPA 1JSWA 1K62A 5D6BA 2O78A 4BAAA 2PTRA 3RD8A 4C5RA 4C6GA 1U16A 2YIIA 5F92A 1GKMA 3R6QA 4APAA 5HW2A 4NSLA 3NO9A 1B8FA 4HGVA 3GZHA 1C3CA 3E04A 2O7EA 2QGAB 1FUOA 2X75A 1GK3A 3KDYA 4FLCA 1HY0A 3QBPA 1AUWA 2NYNA 1HY1A 4V2RA 1GK2A 4C5UA 2QVEA 3R6VA 2RJSA 2O7FA 1EB4A 1W27A 2NYFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C3U A;  2PFM A;  3GTD A;  1U15 A;  4EEI A;  3RRP A;  3OCE A;  1YFE A;  1Q5N A;  1I0A A;  2E9F A;  1T6J A;  3UNV A;  3KDZ A;  1K7W A;  1GKJ A;  2RJR A;  4APB A;  2OHY A;  2PTQ A;  1FUQ A;  1FUR A;  4NLE A;  4C5S A;  4MX2 A;  2O7B A;  3CZO A;  1DOF A;  2FUS A;  1YIS A;  1VDK A;  4FFX A;  2PTS A;  3OCF A;  5EYV A;  1YFM A;  2J91 A;  2O6Y A;  1XWO A;  3NZ4 A;  4V2Q A;  4CQ5 A;  3R6Y A;  5EYT A;  1J3U A;  2HVG A;  3TV2 A;  1TJV A;  3C8T A;  1TJU A;  1T6P A;  5F91 A;  1DCN A;  1Y2M A;  4EFC A;  1TJW A;  3BHG A;  4ADM A;  2O7D A;  4BAB A;  1KQ7 A;  2VD6 A;  4ADL A;  1TJ7 A;  1RE5 A;  1FUP A;  1JSW A;  1K62 A;  5D6B A;  2O78 A;  4BAA A;  2PTR A;  3RD8 A;  4C5R A;  4C6G A;  1U16 A;  2YII A;  5F92 A;  1GKM A;  3R6Q A;  4APA A;  5HW2 A;  4NSL A;  3NO9 A;  1B8F A;  4HGV A;  3GZH A;  1C3C A;  3E04 A;  2O7E A;  2QGA B;  1FUO A;  2X75 A;  1GK3 A;  3KDY A;  4FLC A;  1HY0 A;  3QBP A;  1AUW A;  2NYN A;  1HY1 A;  4V2R A;  1GK2 A;  4C5U A;  2QVE A;  3R6V A;  2RJS A;  2O7F A;  1EB4 A;  1W27 A;  2NYF A; 
#chains in the Genus database with same CATH topology
 1C3U A;  3CRW 1;  2PFM A;  3GTD A;  1U15 A;  4EEI A;  2RCN A;  3RRP A;  3OCE A;  1YFE A;  1XMC A;  1Q5N A;  1I0A A;  2E9F A;  1T6J A;  3UNV A;  3KDZ A;  1K7W A;  3CI0 K;  1GKJ A;  4IQJ M;  2RJR A;  5M0I A;  2D27 A;  4APB A;  2OHY A;  1Z4J A;  2PTQ A;  1FUQ A;  1Q91 A;  1FUR A;  4NLE A;  4C5S A;  4MX2 A;  2O7B A;  3CZO A;  1DOF A;  2FUS A;  1YIS A;  1VDK A;  4FFX A;  5H8W A;  2PTS A;  3CRV A;  3OCF A;  5EYV A;  1YFM A;  1IW7 D;  2J91 A;  2O6Y A;  1XWO A;  3NZ4 A;  4V2Q A;  4CQ5 A;  3R6Y A;  4NFL A;  5EYT A;  1J3U A;  3F4R A;  2HVG A;  4YIK A;  3TV2 A;  4MWO A;  1TJV A;  3C8T A;  1TJU A;  1U0L A;  1T6P A;  5F91 A;  2FEL A;  4MUM A;  1DCN A;  4L6C A;  1Y2M A;  4EFC A;  1TJW A;  3BHG A;  3F4T A;  3U19 A;  4ADM A;  1XL8 A;  2O7D A;  5M0J A;  4BAB A;  1KQ7 A;  2VD6 A;  1TJ7 A;  4ADL A;  4WNL A;  1RE5 A;  1FUP A;  1JSW A;  1K62 A;  5D6B A;  2O78 A;  1Q92 A;  4BAA A;  4A15 A;  1XL7 A;  4L6A A;  2PTR A;  3RD8 A;  2VL7 A;  4C5R A;  2JAR A;  1XLY A;  2JAU A;  4C6G A;  1U16 A;  1Z4L A;  2YII A;  5F92 A;  1GKM A;  1Z4K A;  3R6Q A;  4APA A;  5HW2 A;  4NSL A;  3NO9 A;  1MH9 A;  1B8F A;  1W27 A;  2YV5 A;  3BWV A;  4HGV A;  3GZH A;  1C3C A;  3E04 A;  2O7E A;  2QGA B;  3U13 A;  2FEN A;  1Z4Q A;  1Z4I A;  1Z4P X;  1FUO A;  1T9H A;  4L57 A;  2X75 A;  1GK3 A;  3KDY A;  2JAW A;  4FLC A;  1HY0 A;  4YIH A;  3QBP A;  1Z4M A;  1AUW A;  2NYN A;  1HY1 A;  3F4S A;  4V2R A;  1GK2 A;  4C5U A;  2VSF A;  2QVE A;  2JAO A;  3R6V A;  2RJS A;  2D28 C;  4E88 A;  2O7F A;  1EB4 A;  2I7D A;  1XMD A;  2NYF A; 
#chains in the Genus database with same CATH homology
 1C3U A;  2PFM A;  3GTD A;  1U15 A;  4EEI A;  3RRP A;  3OCE A;  1YFE A;  1Q5N A;  1I0A A;  2E9F A;  1T6J A;  3UNV A;  3KDZ A;  1K7W A;  1GKJ A;  2RJR A;  4APB A;  2OHY A;  2PTQ A;  1FUQ A;  1FUR A;  4NLE A;  4C5S A;  4MX2 A;  2O7B A;  3CZO A;  1DOF A;  2FUS A;  1YIS A;  1VDK A;  4FFX A;  2PTS A;  3OCF A;  5EYV A;  1YFM A;  2J91 A;  2O6Y A;  1XWO A;  3NZ4 A;  4V2Q A;  4CQ5 A;  3R6Y A;  5EYT A;  1J3U A;  2HVG A;  3TV2 A;  1TJV A;  3C8T A;  1TJU A;  1T6P A;  5F91 A;  1DCN A;  1Y2M A;  4EFC A;  1TJW A;  3BHG A;  4ADM A;  2O7D A;  4BAB A;  1KQ7 A;  2VD6 A;  4ADL A;  1TJ7 A;  1RE5 A;  1FUP A;  1JSW A;  1K62 A;  5D6B A;  2O78 A;  4BAA A;  2PTR A;  3RD8 A;  4C5R A;  4C6G A;  1U16 A;  2YII A;  5F92 A;  1GKM A;  3R6Q A;  4APA A;  5HW2 A;  4NSL A;  3NO9 A;  1B8F A;  4HGV A;  3GZH A;  1C3C A;  3E04 A;  2O7E A;  2QGA B;  1FUO A;  2X75 A;  1GK3 A;  3KDY A;  4FLC A;  1HY0 A;  3QBP A;  1AUW A;  2NYN A;  1HY1 A;  4V2R A;  1GK2 A;  4C5U A;  2QVE A;  3R6V A;  2RJS A;  2O7F A;  1EB4 A;  1W27 A;  2NYF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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