5HW2A

Crystal structure of adenylosuccinate lyase from francisella tularensis complexed with fumaric acid
Total Genus 147
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
147
sequence length
438
structure length
419
Chain Sequence
MIKRYDVAEISKIWADENKYAKMLEVELAILEALEDRMVPKGTAAEIRARAQIRPERVDEIEKVTKHDIIAFCTSIAEQFTAETGKFFHFGVTSSDIIDSALSLQIRDSMSYVIKDLEALCDSLLTKAEETKEIITMGRSHGMFAEPMSFGQKFLGAYVEFKRRLKDLKDFQKDGLTVQFSGAVGNYCILTTEDEKKAADILGLPVEEVSTQVIPRDRIAKLISIHGLIASAIERLAVEIRHLHRSDVFEVYEGFKKNPISTENLTGMARMLRSHVSIALENCVLWHERDISHSSAERFYLPDNFGIMVYALRRMKNTIDNLVVQRDIIEDRVRSTSAYLSSFYLHFLVANTPFMREDCYKIVQQVESFSKKLQKVMHDEHNIILDIPEMDFEGIKKTYLKEIDHVFDRSVKARGENLY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Adenylosuccinate Lyase from Francisella tularensis Complexed with fumaric acid
rcsb
source organism Francisella tularensis subsp. tularensis (strain schu s4 / schu 4)
molecule tags Lyase
molecule keywords Adenylosuccinate lyase
total genus 147
structure length 419
sequence length 438
chains with identical sequence B, C, D
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 2016-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 5hw2A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 5hw2A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 5hw2A02
4APAA 1YFEA 1GKMA 5HW2A 1DOFA 1C3CA 2O78A 1TJUA 1GKJA 1FUPA 1T6JA 3KDYA 3RRPA 4V2QA 4V2RA 4NLEA 4ADMA 2RJSA 4C5UA 3E04A 4BAAA 2QGAB 4C6GA 3R6YA 1U16A 1K62A 2X75A 3NZ4A 5EYTA 3NO9A 4BABA 1TJWA 2J91A 1HY1A 4FLCA 1Q5NA 1Y2MA 4CQ5A 2QVEA 5EYVA 3TV2A 1YFMA 1XWOA 1JSWA 2NYNA 1K7WA 4APBA 2O7BA 1FUQA 4EFCA 3GZHA 1FUOA 1U15A 1AUWA 4FFXA 1HY0A 5F92A 3C8TA 2PTQA 1TJ7A 4ADLA 4MX2A 2OHYA 4NSLA 2PTRA 2O7EA 2O7DA 3UNVA 4C5RA 1EB4A 1YISA 1T6PA 1C3UA 1I0AA 1J3UA 3GTDA 3OCFA 1GK2A 1KQ7A 3RD8A 1B8FA 2VD6A 5F91A 2PFMA 5D6BA 2RJRA 2NYFA 2FUSA 1RE5A 2YIIA 3KDZA 3R6QA 4EEIA 4C5SA 2HVGA 1W27A 3R6VA 3CZOA 1DCNA 2PTSA 1VDKA 1GK3A 2O7FA 2E9FA 1FURA 3BHGA 3OCEA 3QBPA 4HGVA 2O6YA 1TJVA
chains in the Genus database with same CATH superfamily
4APAA 1YFEA 1GKMA 3F4TA 5HW2A 4MUMA 1DOFA 1C3CA 2O78A 1TJUA 2FELA 1GKJA 1FUPA 1T6JA 3KDYA 3RRPA 4V2QA 4V2RA 4NLEA 4ADMA 2JAOA 2RJSA 4MWOA 2D28C 4C5UA 1Z4KA 3E04A 4BAAA 2QGAB 2RCNA 4L57A 4C6GA 3R6YA 3BWVA 1U16A 1XL7A 1U0LA 1Q92A 1K62A 2X75A 1Z4LA 3NZ4A 2D27A 5EYTA 4YIKA 3U19A 3NO9A 4BABA 2VL7A 1T9HA 1TJWA 2J91A 1HY1A 5H8WA 3F4SA 1XLYA 4FLCA 1Q5NA 1Y2MA 4CQ5A 2QVEA 5EYVA 1Z4JA 3TV2A 1YFMA 1XWOA 1JSWA 2NYNA 1K7WA 4APBA 2O7BA 1FUQA 4EFCA 3GZHA 1FUOA 1U15A 1AUWA 4FFXA 1Z4QA 5M0JA 1XMCA 1HY0A 5F92A 3C8TA 1Z4MA 2PTQA 1TJ7A 4ADLA 4MX2A 2OHYA 2FENA 2JARA 4NSLA 2PTRA 2O7EA 2O7DA 2JAUA 3UNVA 2JAWA 3CRVA 4C5RA 4L6AA 1EB4A 1YISA 1T6PA 1C3UA 1I0AA 1MH9A 1J3UA 3GTDA 3OCFA 1GK2A 1KQ7A 3RD8A 1B8FA 2VD6A 5F91A 3CRW1 3F4RA 4YIHA 5M0IA 2PFMA 5D6BA 2RJRA 2NYFA 2I7DA 4NFLA 2FUSA 4IQJM 3U13A 4L6CA 1RE5A 4E88A 2YIIA 3KDZA 3R6QA 4EEIA 4C5SA 2HVGA 3CI0K 1W27A 3R6VA 3CZOA 1DCNA 2PTSA 1VDKA 1GK3A 2O7FA 2E9FA 1Q91A 1Z4IA 1FURA 2YV5A 1XMDA 1IW7D 3BHGA 3OCEA 4WNLA 4A15A 2VSFA 3QBPA 1XL8A 4HGVA 2O6YA 1TJVA 1Z4PX
chains in the Genus database with same CATH topology
4APAA 1YFEA 1GKMA 5HW2A 1DOFA 1C3CA 2O78A 1TJUA 1GKJA 1FUPA 1T6JA 3KDYA 3RRPA 4V2QA 4V2RA 4NLEA 4ADMA 2RJSA 4C5UA 3E04A 4BAAA 2QGAB 4C6GA 3R6YA 1U16A 1K62A 2X75A 3NZ4A 5EYTA 3NO9A 4BABA 1TJWA 2J91A 1HY1A 4FLCA 1Q5NA 1Y2MA 4CQ5A 2QVEA 5EYVA 3TV2A 1YFMA 1XWOA 1JSWA 2NYNA 1K7WA 4APBA 2O7BA 1FUQA 4EFCA 3GZHA 1FUOA 1U15A 1AUWA 4FFXA 1HY0A 5F92A 3C8TA 2PTQA 1TJ7A 4ADLA 4MX2A 2OHYA 4NSLA 2PTRA 2O7EA 2O7DA 3UNVA 4C5RA 1EB4A 1YISA 1T6PA 1C3UA 1I0AA 1J3UA 3GTDA 3OCFA 1GK2A 1KQ7A 3RD8A 1B8FA 2VD6A 5F91A 2PFMA 5D6BA 2RJRA 2NYFA 2FUSA 1RE5A 2YIIA 3KDZA 3R6QA 4EEIA 4C5SA 2HVGA 1W27A 3R6VA 3CZOA 1DCNA 2PTSA 1VDKA 1GK3A 2O7FA 2E9FA 1FURA 3BHGA 3OCEA 3QBPA 4HGVA 2O6YA 1TJVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4APA A;  1YFE A;  1GKM A;  5HW2 A;  1DOF A;  1C3C A;  2O78 A;  1TJU A;  1GKJ A;  1FUP A;  1T6J A;  3KDY A;  3RRP A;  4V2Q A;  4V2R A;  4NLE A;  4ADM A;  2RJS A;  4C5U A;  3E04 A;  4BAA A;  2QGA B;  4C6G A;  3R6Y A;  1U16 A;  1K62 A;  2X75 A;  3NZ4 A;  5EYT A;  3NO9 A;  4BAB A;  1TJW A;  2J91 A;  1HY1 A;  4FLC A;  1Q5N A;  1Y2M A;  4CQ5 A;  2QVE A;  5EYV A;  3TV2 A;  1YFM A;  1XWO A;  1JSW A;  2NYN A;  1K7W A;  4APB A;  2O7B A;  1FUQ A;  4EFC A;  3GZH A;  1FUO A;  1U15 A;  1AUW A;  4FFX A;  1HY0 A;  5F92 A;  3C8T A;  2PTQ A;  1TJ7 A;  4ADL A;  4MX2 A;  2OHY A;  4NSL A;  2PTR A;  2O7E A;  2O7D A;  3UNV A;  4C5R A;  1EB4 A;  1YIS A;  1T6P A;  1C3U A;  1I0A A;  1J3U A;  3GTD A;  3OCF A;  1GK2 A;  1KQ7 A;  3RD8 A;  1B8F A;  2VD6 A;  5F91 A;  2PFM A;  5D6B A;  2RJR A;  2NYF A;  2FUS A;  1RE5 A;  2YII A;  3KDZ A;  3R6Q A;  4EEI A;  4C5S A;  2HVG A;  1W27 A;  3R6V A;  3CZO A;  1DCN A;  2PTS A;  1VDK A;  1GK3 A;  2O7F A;  2E9F A;  1FUR A;  3BHG A;  3OCE A;  3QBP A;  4HGV A;  2O6Y A;  1TJV A; 
#chains in the Genus database with same CATH topology
 4APA A;  1YFE A;  1GKM A;  3F4T A;  5HW2 A;  4MUM A;  1DOF A;  1C3C A;  2O78 A;  1TJU A;  2FEL A;  1GKJ A;  1FUP A;  1T6J A;  3KDY A;  3RRP A;  4V2Q A;  4V2R A;  4NLE A;  4ADM A;  2JAO A;  2RJS A;  4MWO A;  2D28 C;  4C5U A;  1Z4K A;  3E04 A;  4BAA A;  2QGA B;  2RCN A;  4L57 A;  4C6G A;  3R6Y A;  3BWV A;  1U16 A;  1XL7 A;  1U0L A;  1Q92 A;  1K62 A;  2X75 A;  1Z4L A;  3NZ4 A;  2D27 A;  5EYT A;  4YIK A;  3U19 A;  3NO9 A;  4BAB A;  2VL7 A;  1T9H A;  1TJW A;  2J91 A;  1HY1 A;  5H8W A;  3F4S A;  1XLY A;  4FLC A;  1Q5N A;  1Y2M A;  4CQ5 A;  2QVE A;  5EYV A;  1Z4J A;  3TV2 A;  1YFM A;  1XWO A;  1JSW A;  2NYN A;  1K7W A;  4APB A;  2O7B A;  1FUQ A;  4EFC A;  3GZH A;  1FUO A;  1U15 A;  1AUW A;  4FFX A;  1Z4Q A;  5M0J A;  1XMC A;  1HY0 A;  5F92 A;  3C8T A;  1Z4M A;  2PTQ A;  1TJ7 A;  4ADL A;  4MX2 A;  2OHY A;  2FEN A;  2JAR A;  4NSL A;  2PTR A;  2O7E A;  2O7D A;  2JAU A;  3UNV A;  2JAW A;  3CRV A;  4C5R A;  4L6A A;  1EB4 A;  1YIS A;  1T6P A;  1C3U A;  1I0A A;  1MH9 A;  1J3U A;  3GTD A;  3OCF A;  1GK2 A;  1KQ7 A;  3RD8 A;  1B8F A;  2VD6 A;  5F91 A;  3CRW 1;  3F4R A;  4YIH A;  5M0I A;  2PFM A;  5D6B A;  2RJR A;  2NYF A;  2I7D A;  4NFL A;  2FUS A;  4IQJ M;  3U13 A;  4L6C A;  1RE5 A;  4E88 A;  2YII A;  3KDZ A;  3R6Q A;  4EEI A;  4C5S A;  2HVG A;  3CI0 K;  1W27 A;  3R6V A;  3CZO A;  1DCN A;  2PTS A;  1VDK A;  1GK3 A;  2O7F A;  2E9F A;  1Q91 A;  1Z4I A;  1FUR A;  2YV5 A;  1XMD A;  1IW7 D;  3BHG A;  3OCE A;  4WNL A;  4A15 A;  2VSF A;  3QBP A;  1XL8 A;  4HGV A;  2O6Y A;  1TJV A;  1Z4P X; 
#chains in the Genus database with same CATH homology
 4APA A;  1YFE A;  1GKM A;  5HW2 A;  1DOF A;  1C3C A;  2O78 A;  1TJU A;  1GKJ A;  1FUP A;  1T6J A;  3KDY A;  3RRP A;  4V2Q A;  4V2R A;  4NLE A;  4ADM A;  2RJS A;  4C5U A;  3E04 A;  4BAA A;  2QGA B;  4C6G A;  3R6Y A;  1U16 A;  1K62 A;  2X75 A;  3NZ4 A;  5EYT A;  3NO9 A;  4BAB A;  1TJW A;  2J91 A;  1HY1 A;  4FLC A;  1Q5N A;  1Y2M A;  4CQ5 A;  2QVE A;  5EYV A;  3TV2 A;  1YFM A;  1XWO A;  1JSW A;  2NYN A;  1K7W A;  4APB A;  2O7B A;  1FUQ A;  4EFC A;  3GZH A;  1FUO A;  1U15 A;  1AUW A;  4FFX A;  1HY0 A;  5F92 A;  3C8T A;  2PTQ A;  1TJ7 A;  4ADL A;  4MX2 A;  2OHY A;  4NSL A;  2PTR A;  2O7E A;  2O7D A;  3UNV A;  4C5R A;  1EB4 A;  1YIS A;  1T6P A;  1C3U A;  1I0A A;  1J3U A;  3GTD A;  3OCF A;  1GK2 A;  1KQ7 A;  3RD8 A;  1B8F A;  2VD6 A;  5F91 A;  2PFM A;  5D6B A;  2RJR A;  2NYF A;  2FUS A;  1RE5 A;  2YII A;  3KDZ A;  3R6Q A;  4EEI A;  4C5S A;  2HVG A;  1W27 A;  3R6V A;  3CZO A;  1DCN A;  2PTS A;  1VDK A;  1GK3 A;  2O7F A;  2E9F A;  1FUR A;  3BHG A;  3OCE A;  3QBP A;  4HGV A;  2O6Y A;  1TJV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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