5HW2A

Crystal structure of adenylosuccinate lyase from francisella tularensis complexed with fumaric acid
Total Genus 147
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
147
sequence length
438
structure length
419
Chain Sequence
MIKRYDVAEISKIWADENKYAKMLEVELAILEALEDRMVPKGTAAEIRARAQIRPERVDEIEKVTKHDIIAFCTSIAEQFTAETGKFFHFGVTSSDIIDSALSLQIRDSMSYVIKDLEALCDSLLTKAEETKEIITMGRSHGMFAEPMSFGQKFLGAYVEFKRRLKDLKDFQKDGLTVQFSGAVGNYCILTTEDEKKAADILGLPVEEVSTQVIPRDRIAKLISIHGLIASAIERLAVEIRHLHRSDVFEVYEGFKKNPISTENLTGMARMLRSHVSIALENCVLWHERDISHSSAERFYLPDNFGIMVYALRRMKNTIDNLVVQRDIIEDRVRSTSAYLSSFYLHFLVANTPFMREDCYKIVQQVESFSKKLQKVMHDEHNIILDIPEMDFEGIKKTYLKEIDHVFDRSVKARGENLY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Adenylosuccinate lyase
publication title Crystal Structure of Adenylosuccinate Lyase from Francisella tularensis Complexed with fumaric acid
rcsb
source organism Francisella tularensis subsp. tularensis (strain schu s4 / schu 4)
molecule tags Lyase
total genus 147
structure length 419
sequence length 438
chains with identical sequence B, C, D
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 2016-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 5hw2A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 5hw2A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 5hw2A02
1DOFA 3KDZA 3R6QA 2O78A 4C6GA 4C5RA 4HGVA 2RJSA 1XWOA 4NLEA 3NZ4A 4BABA 4CQ5A 5HW2A 4ADLA 1RE5A 1W27A 1J3UA 3RRPA 1EB4A 4ADMA 4V2QA 1GK2A 2PTSA 1FUPA 2PTRA 4NSLA 2FUSA 2O7EA 2O6YA 5D6BA 5F92A 1KQ7A 2E9FA 3R6YA 1DCNA 1HY1A 1FUQA 2PFMA 2QGAB 2NYNA 5F91A 4V2RA 3QBPA 1Q5NA 1AUWA 5EYTA 3E04A 1FUOA 4BAAA 4EFCA 3CZOA 4EEIA 2O7BA 1K7WA 1U16A 2O7DA 3NO9A 2HVGA 2VD6A 1TJ7A 1C3CA 1I0AA 3C8TA 1T6PA 4FFXA 4FLCA 1HY0A 1K62A 2X75A 3R6VA 3OCFA 1FURA 4APBA 1TJWA 1YISA 2RJRA 1YFMA 3KDYA 1JSWA 1C3UA 2J91A 4APAA 2YIIA 1Y2MA 2OHYA 4C5SA 1GKJA 4MX2A 1VDKA 1U15A 3OCEA 1B8FA 1TJUA 3TV2A 4C5UA 1T6JA 3RD8A 1TJVA 2NYFA 3UNVA 3GTDA 3BHGA 3GZHA 5EYVA 2PTQA 1GKMA 2O7FA 1GK3A 1YFEA 2QVEA
chains in the Genus database with same CATH superfamily
1DOFA 1Q91A 3KDZA 3R6QA 2O78A 4C6GA 3U19A 4C5RA 4HGVA 2RJSA 1XWOA 4NFLA 4NLEA 3U13A 3NZ4A 2D28C 1XMCA 4BABA 4CQ5A 5HW2A 4ADLA 4YIHA 1RE5A 1W27A 1J3UA 1Z4QA 2YV5A 3RRPA 1EB4A 4ADMA 4V2QA 2JAOA 1GK2A 2PTSA 1FUPA 2PTRA 1Z4LA 4NSLA 2FENA 2RCNA 1Q92A 1XLYA 2FUSA 3CRW1 2O7EA 2O6YA 2JARA 5D6BA 5F92A 1KQ7A 2E9FA 3R6YA 1DCNA 1HY1A 1FUQA 2PFMA 4WNLA 2QGAB 2NYNA 1IW7D 5F91A 3CRVA 4V2RA 4IQJM 3QBPA 1Q5NA 1AUWA 1Z4MA 5EYTA 3E04A 4E88A 3BWVA 1FUOA 1MH9A 4EFCA 4BAAA 3CZOA 1XMDA 4EEIA 2O7BA 1K7WA 1U16A 1XL7A 2O7DA 5M0JA 4L6AA 1Z4PX 3NO9A 2HVGA 2VD6A 1TJ7A 1C3CA 1I0AA 2I7DA 1T9HA 3C8TA 4MWOA 1T6PA 4FFXA 3CI0K 4FLCA 1HY0A 1K62A 4MUMA 2D27A 2X75A 3R6VA 2VSFA 3OCFA 3F4TA 1FURA 4APBA 1TJWA 1YISA 2RJRA 1Z4KA 4A15A 2JAWA 1YFMA 1Z4JA 3KDYA 1JSWA 1C3UA 1U0LA 2FELA 2J91A 4APAA 2YIIA 1Y2MA 2OHYA 2JAUA 2VL7A 4C5SA 1GKJA 4MX2A 1VDKA 3F4SA 1U15A 3OCEA 1B8FA 1TJUA 1Z4IA 3TV2A 4C5UA 1T6JA 4L6CA 4YIKA 3RD8A 3F4RA 1XL8A 1TJVA 5M0IA 2NYFA 3UNVA 3GTDA 3BHGA 3GZHA 5EYVA 2PTQA 4L57A 1GKMA 2O7FA 5H8WA 1GK3A 1YFEA 2QVEA
chains in the Genus database with same CATH topology
1DOFA 3KDZA 3R6QA 2O78A 4C6GA 4C5RA 4HGVA 2RJSA 1XWOA 4NLEA 3NZ4A 4BABA 4CQ5A 5HW2A 4ADLA 1RE5A 1W27A 1J3UA 3RRPA 1EB4A 4ADMA 4V2QA 1GK2A 2PTSA 1FUPA 2PTRA 4NSLA 2FUSA 2O7EA 2O6YA 5D6BA 5F92A 1KQ7A 2E9FA 3R6YA 1DCNA 1HY1A 1FUQA 2PFMA 2QGAB 2NYNA 5F91A 4V2RA 3QBPA 1Q5NA 1AUWA 5EYTA 3E04A 1FUOA 4BAAA 4EFCA 3CZOA 4EEIA 2O7BA 1K7WA 1U16A 2O7DA 3NO9A 2HVGA 2VD6A 1TJ7A 1C3CA 1I0AA 3C8TA 1T6PA 4FFXA 4FLCA 1HY0A 1K62A 2X75A 3R6VA 3OCFA 1FURA 4APBA 1TJWA 1YISA 2RJRA 1YFMA 3KDYA 1JSWA 1C3UA 2J91A 4APAA 2YIIA 1Y2MA 2OHYA 4C5SA 1GKJA 4MX2A 1VDKA 1U15A 3OCEA 1B8FA 1TJUA 3TV2A 4C5UA 1T6JA 3RD8A 1TJVA 2NYFA 3UNVA 3GTDA 3BHGA 3GZHA 5EYVA 2PTQA 1GKMA 2O7FA 1GK3A 1YFEA 2QVEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DOF A;  3KDZ A;  3R6Q A;  2O78 A;  4C6G A;  4C5R A;  4HGV A;  2RJS A;  1XWO A;  4NLE A;  3NZ4 A;  4BAB A;  4CQ5 A;  5HW2 A;  4ADL A;  1RE5 A;  1W27 A;  1J3U A;  3RRP A;  1EB4 A;  4ADM A;  4V2Q A;  1GK2 A;  2PTS A;  1FUP A;  2PTR A;  4NSL A;  2FUS A;  2O7E A;  2O6Y A;  5D6B A;  5F92 A;  1KQ7 A;  2E9F A;  3R6Y A;  1DCN A;  1HY1 A;  1FUQ A;  2PFM A;  2QGA B;  2NYN A;  5F91 A;  4V2R A;  3QBP A;  1Q5N A;  1AUW A;  5EYT A;  3E04 A;  1FUO A;  4BAA A;  4EFC A;  3CZO A;  4EEI A;  2O7B A;  1K7W A;  1U16 A;  2O7D A;  3NO9 A;  2HVG A;  2VD6 A;  1TJ7 A;  1C3C A;  1I0A A;  3C8T A;  1T6P A;  4FFX A;  4FLC A;  1HY0 A;  1K62 A;  2X75 A;  3R6V A;  3OCF A;  1FUR A;  4APB A;  1TJW A;  1YIS A;  2RJR A;  1YFM A;  3KDY A;  1JSW A;  1C3U A;  2J91 A;  4APA A;  2YII A;  1Y2M A;  2OHY A;  4C5S A;  1GKJ A;  4MX2 A;  1VDK A;  1U15 A;  3OCE A;  1B8F A;  1TJU A;  3TV2 A;  4C5U A;  1T6J A;  3RD8 A;  1TJV A;  2NYF A;  3UNV A;  3GTD A;  3BHG A;  3GZH A;  5EYV A;  2PTQ A;  1GKM A;  2O7F A;  1GK3 A;  1YFE A;  2QVE A; 
#chains in the Genus database with same CATH topology
 1DOF A;  1Q91 A;  3KDZ A;  3R6Q A;  2O78 A;  4C6G A;  3U19 A;  4C5R A;  4HGV A;  2RJS A;  1XWO A;  4NFL A;  4NLE A;  3U13 A;  3NZ4 A;  2D28 C;  1XMC A;  4BAB A;  4CQ5 A;  5HW2 A;  4ADL A;  4YIH A;  1RE5 A;  1W27 A;  1J3U A;  1Z4Q A;  2YV5 A;  3RRP A;  1EB4 A;  4ADM A;  4V2Q A;  2JAO A;  1GK2 A;  2PTS A;  1FUP A;  2PTR A;  1Z4L A;  4NSL A;  2FEN A;  2RCN A;  1Q92 A;  1XLY A;  2FUS A;  3CRW 1;  2O7E A;  2O6Y A;  2JAR A;  5D6B A;  5F92 A;  1KQ7 A;  2E9F A;  3R6Y A;  1DCN A;  1HY1 A;  1FUQ A;  2PFM A;  4WNL A;  2QGA B;  2NYN A;  1IW7 D;  5F91 A;  3CRV A;  4V2R A;  4IQJ M;  3QBP A;  1Q5N A;  1AUW A;  1Z4M A;  5EYT A;  3E04 A;  4E88 A;  3BWV A;  1FUO A;  1MH9 A;  4EFC A;  4BAA A;  3CZO A;  1XMD A;  4EEI A;  2O7B A;  1K7W A;  1U16 A;  1XL7 A;  2O7D A;  5M0J A;  4L6A A;  1Z4P X;  3NO9 A;  2HVG A;  2VD6 A;  1TJ7 A;  1C3C A;  1I0A A;  2I7D A;  1T9H A;  3C8T A;  4MWO A;  1T6P A;  4FFX A;  3CI0 K;  4FLC A;  1HY0 A;  1K62 A;  4MUM A;  2D27 A;  2X75 A;  3R6V A;  2VSF A;  3OCF A;  3F4T A;  1FUR A;  4APB A;  1TJW A;  1YIS A;  2RJR A;  1Z4K A;  4A15 A;  2JAW A;  1YFM A;  1Z4J A;  3KDY A;  1JSW A;  1C3U A;  1U0L A;  2FEL A;  2J91 A;  4APA A;  2YII A;  1Y2M A;  2OHY A;  2JAU A;  2VL7 A;  4C5S A;  1GKJ A;  4MX2 A;  1VDK A;  3F4S A;  1U15 A;  3OCE A;  1B8F A;  1TJU A;  1Z4I A;  3TV2 A;  4C5U A;  1T6J A;  4L6C A;  4YIK A;  3RD8 A;  3F4R A;  1XL8 A;  1TJV A;  5M0I A;  2NYF A;  3UNV A;  3GTD A;  3BHG A;  3GZH A;  5EYV A;  2PTQ A;  4L57 A;  1GKM A;  2O7F A;  5H8W A;  1GK3 A;  1YFE A;  2QVE A; 
#chains in the Genus database with same CATH homology
 1DOF A;  3KDZ A;  3R6Q A;  2O78 A;  4C6G A;  4C5R A;  4HGV A;  2RJS A;  1XWO A;  4NLE A;  3NZ4 A;  4BAB A;  4CQ5 A;  5HW2 A;  4ADL A;  1RE5 A;  1W27 A;  1J3U A;  3RRP A;  1EB4 A;  4ADM A;  4V2Q A;  1GK2 A;  2PTS A;  1FUP A;  2PTR A;  4NSL A;  2FUS A;  2O7E A;  2O6Y A;  5D6B A;  5F92 A;  1KQ7 A;  2E9F A;  3R6Y A;  1DCN A;  1HY1 A;  1FUQ A;  2PFM A;  2QGA B;  2NYN A;  5F91 A;  4V2R A;  3QBP A;  1Q5N A;  1AUW A;  5EYT A;  3E04 A;  1FUO A;  4BAA A;  4EFC A;  3CZO A;  4EEI A;  2O7B A;  1K7W A;  1U16 A;  2O7D A;  3NO9 A;  2HVG A;  2VD6 A;  1TJ7 A;  1C3C A;  1I0A A;  3C8T A;  1T6P A;  4FFX A;  4FLC A;  1HY0 A;  1K62 A;  2X75 A;  3R6V A;  3OCF A;  1FUR A;  4APB A;  1TJW A;  1YIS A;  2RJR A;  1YFM A;  3KDY A;  1JSW A;  1C3U A;  2J91 A;  4APA A;  2YII A;  1Y2M A;  2OHY A;  4C5S A;  1GKJ A;  4MX2 A;  1VDK A;  1U15 A;  3OCE A;  1B8F A;  1TJU A;  3TV2 A;  4C5U A;  1T6J A;  3RD8 A;  1TJV A;  2NYF A;  3UNV A;  3GTD A;  3BHG A;  3GZH A;  5EYV A;  2PTQ A;  1GKM A;  2O7F A;  1GK3 A;  1YFE A;  2QVE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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