5HW2A

Crystal structure of adenylosuccinate lyase from francisella tularensis complexed with fumaric acid
Total Genus 147
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
147
sequence length
438
structure length
419
Chain Sequence
MIKRYDVAEISKIWADENKYAKMLEVELAILEALEDRMVPKGTAAEIRARAQIRPERVDEIEKVTKHDIIAFCTSIAEQFTAETGKFFHFGVTSSDIIDSALSLQIRDSMSYVIKDLEALCDSLLTKAEETKEIITMGRSHGMFAEPMSFGQKFLGAYVEFKRRLKDLKDFQKDGLTVQFSGAVGNYCILTTEDEKKAADILGLPVEEVSTQVIPRDRIAKLISIHGLIASAIERLAVEIRHLHRSDVFEVYEGFKKNPISTENLTGMARMLRSHVSIALENCVLWHERDISHSSAERFYLPDNFGIMVYALRRMKNTIDNLVVQRDIIEDRVRSTSAYLSSFYLHFLVANTPFMREDCYKIVQQVESFSKKLQKVMHDEHNIILDIPEMDFEGIKKTYLKEIDHVFDRSVKARGENLY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of Adenylosuccinate Lyase from Francisella tularensis Complexed with fumaric acid
rcsb
source organism Francisella tularensis subsp. tularensis (strain schu s4 / schu 4)
molecule tags Lyase
molecule keywords Adenylosuccinate lyase
total genus 147
structure length 419
sequence length 438
chains with identical sequence B, C, D
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 2016-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 5hw2A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 5hw2A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 5hw2A02
4FLCA 3GZHA 3R6QA 2O6YA 2RJRA 1GKMA 1T6PA 1K62A 1C3UA 2YIIA 4CQ5A 3C8TA 4NLEA 4V2RA 1J3UA 4FFXA 1XWOA 1DOFA 1I0AA 2NYFA 1JSWA 4BABA 3CZOA 4C5UA 1TJUA 2PTQA 1VDKA 1GK2A 2J91A 3KDZA 3TV2A 5F91A 4NSLA 1TJVA 5HW2A 4EEIA 4HGVA 4APAA 1K7WA 1Y2MA 4BAAA 2O7FA 1DCNA 2OHYA 3OCFA 4C6GA 3R6VA 4EFCA 4V2QA 1Q5NA 1FURA 1T6JA 5D6BA 1HY0A 1FUQA 2O7BA 1GK3A 3OCEA 2QVEA 2HVGA 2VD6A 5EYTA 1FUPA 2PFMA 3NZ4A 1RE5A 2QGAB 3E04A 2O7DA 2NYNA 3KDYA 1U15A 2FUSA 1FUOA 2RJSA 1U16A 1GKJA 1HY1A 1YISA 2PTRA 3GTDA 3BHGA 1W27A 1B8FA 1C3CA 4MX2A 4C5SA 2O7EA 2X75A 2O78A 1TJWA 3R6YA 4C5RA 1EB4A 3RD8A 4ADMA 4APBA 3NO9A 1AUWA 1KQ7A 1TJ7A 5EYVA 1YFEA 2PTSA 5F92A 2E9FA 3UNVA 3RRPA 3QBPA 4ADLA 1YFMA
chains in the Genus database with same CATH superfamily
4FLCA 3GZHA 4MWOA 3R6QA 3F4SA 2O6YA 2RJRA 1GKMA 1T6PA 1K62A 1C3UA 2RCNA 2YIIA 4CQ5A 3C8TA 4NLEA 4WNLA 5M0IA 4V2RA 1J3UA 4FFXA 1XWOA 2JARA 3CRVA 1DOFA 1I0AA 2NYFA 4YIKA 1JSWA 4BABA 3CZOA 5M0JA 4L6CA 4C5UA 1TJUA 2PTQA 1VDKA 1GK2A 2J91A 3KDZA 3TV2A 5F91A 4NSLA 5H8WA 1TJVA 2D28C 5HW2A 4EEIA 1Q92A 4HGVA 4APAA 1K7WA 4E88A 1Y2MA 4BAAA 1Z4JA 2JAOA 4MUMA 2O7FA 1DCNA 2OHYA 3OCFA 4C6GA 3R6VA 2D27A 2JAWA 4EFCA 1XL8A 4V2QA 1Q5NA 1FURA 1T6JA 1Z4QA 1Z4KA 5D6BA 1HY0A 2VL7A 4A15A 1FUQA 2O7BA 2YV5A 3BWVA 1GK3A 3OCEA 1Z4MA 2HVGA 1IW7D 2QVEA 2VD6A 5EYTA 1FUPA 2PFMA 1T9HA 3NZ4A 1RE5A 1XMCA 2JAUA 2VSFA 2QGAB 3CI0K 3E04A 2O7DA 1U0LA 2NYNA 3KDYA 1U15A 2FUSA 1Z4IA 1FUOA 2RJSA 1U16A 1GKJA 4L57A 3F4TA 4YIHA 1Z4PX 1HY1A 1YISA 2PTRA 1XLYA 4NFLA 1XL7A 3GTDA 3U13A 3BHGA 2FELA 1W27A 1B8FA 1C3CA 3U19A 4MX2A 1XMDA 4C5SA 2O7EA 2X75A 2O78A 1TJWA 2I7DA 3R6YA 4C5RA 1EB4A 1Z4LA 3RD8A 4L6AA 4ADMA 2FENA 4APBA 3NO9A 1MH9A 1Q91A 1AUWA 1KQ7A 1TJ7A 4IQJM 5EYVA 1YFEA 2PTSA 5F92A 3CRW1 3F4RA 2E9FA 3UNVA 3RRPA 3QBPA 4ADLA 1YFMA
chains in the Genus database with same CATH topology
4FLCA 3GZHA 3R6QA 2O6YA 2RJRA 1GKMA 1T6PA 1K62A 1C3UA 2YIIA 4CQ5A 3C8TA 4NLEA 4V2RA 1J3UA 4FFXA 1XWOA 1DOFA 1I0AA 2NYFA 1JSWA 4BABA 3CZOA 4C5UA 1TJUA 2PTQA 1VDKA 1GK2A 2J91A 3KDZA 3TV2A 5F91A 4NSLA 1TJVA 5HW2A 4EEIA 4HGVA 4APAA 1K7WA 1Y2MA 4BAAA 2O7FA 1DCNA 2OHYA 3OCFA 4C6GA 3R6VA 4EFCA 4V2QA 1Q5NA 1FURA 1T6JA 5D6BA 1HY0A 1FUQA 2O7BA 1GK3A 3OCEA 2QVEA 2HVGA 2VD6A 5EYTA 1FUPA 2PFMA 3NZ4A 1RE5A 2QGAB 3E04A 2O7DA 2NYNA 3KDYA 1U15A 2FUSA 1FUOA 2RJSA 1U16A 1GKJA 1HY1A 1YISA 2PTRA 3GTDA 3BHGA 1W27A 1B8FA 1C3CA 4MX2A 4C5SA 2O7EA 2X75A 2O78A 1TJWA 3R6YA 4C5RA 1EB4A 3RD8A 4ADMA 4APBA 3NO9A 1AUWA 1KQ7A 1TJ7A 5EYVA 1YFEA 2PTSA 5F92A 2E9FA 3UNVA 3RRPA 3QBPA 4ADLA 1YFMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FLC A;  3GZH A;  3R6Q A;  2O6Y A;  2RJR A;  1GKM A;  1T6P A;  1K62 A;  1C3U A;  2YII A;  4CQ5 A;  3C8T A;  4NLE A;  4V2R A;  1J3U A;  4FFX A;  1XWO A;  1DOF A;  1I0A A;  2NYF A;  1JSW A;  4BAB A;  3CZO A;  4C5U A;  1TJU A;  2PTQ A;  1VDK A;  1GK2 A;  2J91 A;  3KDZ A;  3TV2 A;  5F91 A;  4NSL A;  1TJV A;  5HW2 A;  4EEI A;  4HGV A;  4APA A;  1K7W A;  1Y2M A;  4BAA A;  2O7F A;  1DCN A;  2OHY A;  3OCF A;  4C6G A;  3R6V A;  4EFC A;  4V2Q A;  1Q5N A;  1FUR A;  1T6J A;  5D6B A;  1HY0 A;  1FUQ A;  2O7B A;  1GK3 A;  3OCE A;  2QVE A;  2HVG A;  2VD6 A;  5EYT A;  1FUP A;  2PFM A;  3NZ4 A;  1RE5 A;  2QGA B;  3E04 A;  2O7D A;  2NYN A;  3KDY A;  1U15 A;  2FUS A;  1FUO A;  2RJS A;  1U16 A;  1GKJ A;  1HY1 A;  1YIS A;  2PTR A;  3GTD A;  3BHG A;  1W27 A;  1B8F A;  1C3C A;  4MX2 A;  4C5S A;  2O7E A;  2X75 A;  2O78 A;  1TJW A;  3R6Y A;  4C5R A;  1EB4 A;  3RD8 A;  4ADM A;  4APB A;  3NO9 A;  1AUW A;  1KQ7 A;  1TJ7 A;  5EYV A;  1YFE A;  2PTS A;  5F92 A;  2E9F A;  3UNV A;  3RRP A;  3QBP A;  4ADL A;  1YFM A; 
#chains in the Genus database with same CATH topology
 4FLC A;  3GZH A;  4MWO A;  3R6Q A;  3F4S A;  2O6Y A;  2RJR A;  1GKM A;  1T6P A;  1K62 A;  1C3U A;  2RCN A;  2YII A;  4CQ5 A;  3C8T A;  4NLE A;  4WNL A;  5M0I A;  4V2R A;  1J3U A;  4FFX A;  1XWO A;  2JAR A;  3CRV A;  1DOF A;  1I0A A;  2NYF A;  4YIK A;  1JSW A;  4BAB A;  3CZO A;  5M0J A;  4L6C A;  4C5U A;  1TJU A;  2PTQ A;  1VDK A;  1GK2 A;  2J91 A;  3KDZ A;  3TV2 A;  5F91 A;  4NSL A;  5H8W A;  1TJV A;  2D28 C;  5HW2 A;  4EEI A;  1Q92 A;  4HGV A;  4APA A;  1K7W A;  4E88 A;  1Y2M A;  4BAA A;  1Z4J A;  2JAO A;  4MUM A;  2O7F A;  1DCN A;  2OHY A;  3OCF A;  4C6G A;  3R6V A;  2D27 A;  2JAW A;  4EFC A;  1XL8 A;  4V2Q A;  1Q5N A;  1FUR A;  1T6J A;  1Z4Q A;  1Z4K A;  5D6B A;  1HY0 A;  2VL7 A;  4A15 A;  1FUQ A;  2O7B A;  2YV5 A;  3BWV A;  1GK3 A;  3OCE A;  1Z4M A;  2HVG A;  1IW7 D;  2QVE A;  2VD6 A;  5EYT A;  1FUP A;  2PFM A;  1T9H A;  3NZ4 A;  1RE5 A;  1XMC A;  2JAU A;  2VSF A;  2QGA B;  3CI0 K;  3E04 A;  2O7D A;  1U0L A;  2NYN A;  3KDY A;  1U15 A;  2FUS A;  1Z4I A;  1FUO A;  2RJS A;  1U16 A;  1GKJ A;  4L57 A;  3F4T A;  4YIH A;  1Z4P X;  1HY1 A;  1YIS A;  2PTR A;  1XLY A;  4NFL A;  1XL7 A;  3GTD A;  3U13 A;  3BHG A;  2FEL A;  1W27 A;  1B8F A;  1C3C A;  3U19 A;  4MX2 A;  1XMD A;  4C5S A;  2O7E A;  2X75 A;  2O78 A;  1TJW A;  2I7D A;  3R6Y A;  4C5R A;  1EB4 A;  1Z4L A;  3RD8 A;  4L6A A;  4ADM A;  2FEN A;  4APB A;  3NO9 A;  1MH9 A;  1Q91 A;  1AUW A;  1KQ7 A;  1TJ7 A;  4IQJ M;  5EYV A;  1YFE A;  2PTS A;  5F92 A;  3CRW 1;  3F4R A;  2E9F A;  3UNV A;  3RRP A;  3QBP A;  4ADL A;  1YFM A; 
#chains in the Genus database with same CATH homology
 4FLC A;  3GZH A;  3R6Q A;  2O6Y A;  2RJR A;  1GKM A;  1T6P A;  1K62 A;  1C3U A;  2YII A;  4CQ5 A;  3C8T A;  4NLE A;  4V2R A;  1J3U A;  4FFX A;  1XWO A;  1DOF A;  1I0A A;  2NYF A;  1JSW A;  4BAB A;  3CZO A;  4C5U A;  1TJU A;  2PTQ A;  1VDK A;  1GK2 A;  2J91 A;  3KDZ A;  3TV2 A;  5F91 A;  4NSL A;  1TJV A;  5HW2 A;  4EEI A;  4HGV A;  4APA A;  1K7W A;  1Y2M A;  4BAA A;  2O7F A;  1DCN A;  2OHY A;  3OCF A;  4C6G A;  3R6V A;  4EFC A;  4V2Q A;  1Q5N A;  1FUR A;  1T6J A;  5D6B A;  1HY0 A;  1FUQ A;  2O7B A;  1GK3 A;  3OCE A;  2QVE A;  2HVG A;  2VD6 A;  5EYT A;  1FUP A;  2PFM A;  3NZ4 A;  1RE5 A;  2QGA B;  3E04 A;  2O7D A;  2NYN A;  3KDY A;  1U15 A;  2FUS A;  1FUO A;  2RJS A;  1U16 A;  1GKJ A;  1HY1 A;  1YIS A;  2PTR A;  3GTD A;  3BHG A;  1W27 A;  1B8F A;  1C3C A;  4MX2 A;  4C5S A;  2O7E A;  2X75 A;  2O78 A;  1TJW A;  3R6Y A;  4C5R A;  1EB4 A;  3RD8 A;  4ADM A;  4APB A;  3NO9 A;  1AUW A;  1KQ7 A;  1TJ7 A;  5EYV A;  1YFE A;  2PTS A;  5F92 A;  2E9F A;  3UNV A;  3RRP A;  3QBP A;  4ADL A;  1YFM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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