1GKMA

Histidine ammonia-lyase (hal) from pseudomonas putida inhibited with l-cysteine
Total Genus 202
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
202
sequence length
507
structure length
506
Chain Sequence
TELTLKPGTLTLAQLRAIHAAPVRLQLDASAAPAIDASVACVEQIIAEDRTAYGINTGFGLLASTRIASHDLENLQRSLVLSHAAGIGAPLDDDLVRLIMVLKINSLSRGFSGIRRKVIDALIALVNAEVYPHIPLKGSVGDLAPLAHMSLVLLGEGKARYKGQWLSATEALAVAGLEPLTLAAKEGLALLNGTQASTAYALRGLFYAEDLYAAAIACGGLSVEAVLGSRSPFDARIHEARGQRGQIDTAACFRDLLGDSSEVSLSHKNADKVQDPYSLRCQPQVMGACLTQLRQAAEVLGIEANAVSDNPLVFAAEGDVISGGNFHAEPVAMAADNLALAIAEIGSLSERRISLMMDKHMSQLPPFLVENGGVNSGFMIAQVTAAALASENKALSHPHSVDSLPTSANQEDHVSMAPAAGKRLWEMAENTRGVLAIEWLGACQGLDLRKGLKTSAKLEKARQALRSEVAHYDRDRFFAPDIEKAVELLAKGSLTGLLPAGVLPSL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords HISTIDINE AMMONIA-LYASE
publication title Structures of Two Histidine Ammonia-Lyase Modifications and Implications for the Catalytic Mechanism
pubmed doi rcsb
source organism Pseudomonas putida
molecule tags Lyase
total genus 202
structure length 506
sequence length 507
ec nomenclature ec 4.3.1.3: Histidine ammonia-lyase.
pdb deposition date 2001-08-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1gkmA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1gkmA02
1GK2A 2QGAB 2QVEA 4ADLA 1VDKA 2O78A 4APBA 1U15A 1C3CA 1T6JA 1YISA 1Q5NA 3GZHA 2OHYA 3RRPA 3E04A 2J91A 1T6PA 1GK3A 3QBPA 4BABA 1J3UA 1YFMA 3BHGA 1DOFA 3OCEA 1GKMA 5EYTA 3NZ4A 1FUQA 1FUPA 2O7BA 2HVGA 3OCFA 3UNVA 3CZOA 2RJRA 2FUSA 1EB4A 3GTDA 4ADMA 2E9FA 4C5RA 3KDZA 4NLEA 1Y2MA 2PTRA 1AUWA 1I0AA 4EFCA 1XWOA 4CQ5A 1DCNA 2VD6A 5F91A 1W27A 4V2QA 1GKJA 1C3UA 1HY1A 1U16A 3NO9A 5F92A 4NSLA 4FFXA 2NYFA 2PFMA 1TJWA 4C5UA 2RJSA 1HY0A 2NYNA 4APAA 3C8TA 2PTSA 2O6YA 3RD8A 1B8FA 4V2RA 1RE5A 1TJ7A 1JSWA 3R6QA 4BAAA 1YFEA 1KQ7A 3R6VA 2O7EA 1TJVA 4HGVA 2PTQA 5EYVA 1FURA 5HW2A 2O7FA 1TJUA 5D6BA 2O7DA 4C5SA 1K62A 3TV2A 4EEIA 4C6GA 1FUOA 2YIIA 4FLCA 4MX2A 3R6YA 1K7WA 2X75A 3KDYA
chains in the Genus database with same CATH superfamily
1GK2A 2QGAB 2VL7A 2QVEA 4ADLA 1VDKA 2O78A 4APBA 1U15A 1C3CA 1T6JA 1YISA 1Q5NA 1XMDA 3GZHA 2OHYA 3RRPA 3E04A 2J91A 1T6PA 1GK3A 3QBPA 4BABA 1J3UA 1YFMA 3BHGA 1DOFA 3OCEA 5H8WA 1GKMA 5EYTA 3NZ4A 1FUQA 1FUPA 2O7BA 2HVGA 1XLYA 3OCFA 3UNVA 3CZOA 2RJRA 2FUSA 1EB4A 1XL8A 3GTDA 4ADMA 2E9FA 4C5RA 3KDZA 4NLEA 1Y2MA 2PTRA 1AUWA 1I0AA 4EFCA 2FENA 1XWOA 4CQ5A 1DCNA 2VD6A 5F91A 1W27A 4V2QA 1XL7A 1GKJA 1C3UA 1HY1A 1U16A 5M0IA 3NO9A 5F92A 4A15A 4NSLA 4FFXA 2NYFA 5M0JA 2PFMA 1TJWA 4C5UA 2RJSA 1HY0A 2NYNA 4APAA 3C8TA 2PTSA 2O6YA 3RD8A 1B8FA 4V2RA 1RE5A 1TJ7A 1JSWA 3R6QA 4BAAA 2VSFA 3CRW1 1YFEA 1KQ7A 3R6VA 2O7EA 1TJVA 4HGVA 2PTQA 5EYVA 2FELA 1FURA 5HW2A 2O7FA 1TJUA 5D6BA 2O7DA 4C5SA 1K62A 3TV2A 4EEIA 4C6GA 1FUOA 1XMCA 2YIIA 3CRVA 4FLCA 4MX2A 3R6YA 1K7WA 2X75A 3KDYA 4WNLA
chains in the Genus database with same CATH topology
1GK2A 2QGAB 2QVEA 4ADLA 1VDKA 2O78A 4APBA 1U15A 1C3CA 1T6JA 1YISA 1Q5NA 3GZHA 2OHYA 3RRPA 3E04A 2J91A 1T6PA 1GK3A 3QBPA 4BABA 1J3UA 1YFMA 3BHGA 1DOFA 3OCEA 1GKMA 5EYTA 3NZ4A 1FUQA 1FUPA 2O7BA 2HVGA 3OCFA 3UNVA 3CZOA 2RJRA 2FUSA 1EB4A 3GTDA 4ADMA 2E9FA 4C5RA 3KDZA 4NLEA 1Y2MA 2PTRA 1AUWA 1I0AA 4EFCA 1XWOA 4CQ5A 1DCNA 2VD6A 5F91A 1W27A 4V2QA 1GKJA 1C3UA 1HY1A 1U16A 3NO9A 5F92A 4NSLA 4FFXA 2NYFA 2PFMA 1TJWA 4C5UA 2RJSA 1HY0A 2NYNA 4APAA 3C8TA 2PTSA 2O6YA 3RD8A 1B8FA 4V2RA 1RE5A 1TJ7A 1JSWA 3R6QA 4BAAA 1YFEA 1KQ7A 3R6VA 2O7EA 1TJVA 4HGVA 2PTQA 5EYVA 1FURA 5HW2A 2O7FA 1TJUA 5D6BA 2O7DA 4C5SA 1K62A 3TV2A 4EEIA 4C6GA 1FUOA 2YIIA 4FLCA 4MX2A 3R6YA 1K7WA 2X75A 3KDYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1GK2 A;  2QGA B;  2QVE A;  4ADL A;  1VDK A;  2O78 A;  4APB A;  1U15 A;  1C3C A;  1T6J A;  1YIS A;  1Q5N A;  3GZH A;  2OHY A;  3RRP A;  3E04 A;  2J91 A;  1T6P A;  1GK3 A;  3QBP A;  4BAB A;  1J3U A;  1YFM A;  3BHG A;  1DOF A;  3OCE A;  1GKM A;  5EYT A;  3NZ4 A;  1FUQ A;  1FUP A;  2O7B A;  2HVG A;  3OCF A;  3UNV A;  3CZO A;  2RJR A;  2FUS A;  1EB4 A;  3GTD A;  4ADM A;  2E9F A;  4C5R A;  3KDZ A;  4NLE A;  1Y2M A;  2PTR A;  1AUW A;  1I0A A;  4EFC A;  1XWO A;  4CQ5 A;  1DCN A;  2VD6 A;  5F91 A;  1W27 A;  4V2Q A;  1GKJ A;  1C3U A;  1HY1 A;  1U16 A;  3NO9 A;  5F92 A;  4NSL A;  4FFX A;  2NYF A;  2PFM A;  1TJW A;  4C5U A;  2RJS A;  1HY0 A;  2NYN A;  4APA A;  3C8T A;  2PTS A;  2O6Y A;  3RD8 A;  1B8F A;  4V2R A;  1RE5 A;  1TJ7 A;  1JSW A;  3R6Q A;  4BAA A;  1YFE A;  1KQ7 A;  3R6V A;  2O7E A;  1TJV A;  4HGV A;  2PTQ A;  5EYV A;  1FUR A;  5HW2 A;  2O7F A;  1TJU A;  5D6B A;  2O7D A;  4C5S A;  1K62 A;  3TV2 A;  4EEI A;  4C6G A;  1FUO A;  2YII A;  4FLC A;  4MX2 A;  3R6Y A;  1K7W A;  2X75 A;  3KDY A; 
#chains in the Genus database with same CATH topology
 1GK2 A;  2QGA B;  2VL7 A;  2QVE A;  4ADL A;  1VDK A;  2O78 A;  4APB A;  1U15 A;  1C3C A;  1T6J A;  1YIS A;  1Q5N A;  1XMD A;  3GZH A;  2OHY A;  3RRP A;  3E04 A;  2J91 A;  1T6P A;  1GK3 A;  3QBP A;  4BAB A;  1J3U A;  1YFM A;  3BHG A;  1DOF A;  3OCE A;  5H8W A;  1GKM A;  5EYT A;  3NZ4 A;  1FUQ A;  1FUP A;  2O7B A;  2HVG A;  1XLY A;  3OCF A;  3UNV A;  3CZO A;  2RJR A;  2FUS A;  1EB4 A;  1XL8 A;  3GTD A;  4ADM A;  2E9F A;  4C5R A;  3KDZ A;  4NLE A;  1Y2M A;  2PTR A;  1AUW A;  1I0A A;  4EFC A;  2FEN A;  1XWO A;  4CQ5 A;  1DCN A;  2VD6 A;  5F91 A;  1W27 A;  4V2Q A;  1XL7 A;  1GKJ A;  1C3U A;  1HY1 A;  1U16 A;  5M0I A;  3NO9 A;  5F92 A;  4A15 A;  4NSL A;  4FFX A;  2NYF A;  5M0J A;  2PFM A;  1TJW A;  4C5U A;  2RJS A;  1HY0 A;  2NYN A;  4APA A;  3C8T A;  2PTS A;  2O6Y A;  3RD8 A;  1B8F A;  4V2R A;  1RE5 A;  1TJ7 A;  1JSW A;  3R6Q A;  4BAA A;  2VSF A;  3CRW 1;  1YFE A;  1KQ7 A;  3R6V A;  2O7E A;  1TJV A;  4HGV A;  2PTQ A;  5EYV A;  2FEL A;  1FUR A;  5HW2 A;  2O7F A;  1TJU A;  5D6B A;  2O7D A;  4C5S A;  1K62 A;  3TV2 A;  4EEI A;  4C6G A;  1FUO A;  1XMC A;  2YII A;  3CRV A;  4FLC A;  4MX2 A;  3R6Y A;  1K7W A;  2X75 A;  3KDY A;  4WNL A; 
#chains in the Genus database with same CATH homology
 1GK2 A;  2QGA B;  2QVE A;  4ADL A;  1VDK A;  2O78 A;  4APB A;  1U15 A;  1C3C A;  1T6J A;  1YIS A;  1Q5N A;  3GZH A;  2OHY A;  3RRP A;  3E04 A;  2J91 A;  1T6P A;  1GK3 A;  3QBP A;  4BAB A;  1J3U A;  1YFM A;  3BHG A;  1DOF A;  3OCE A;  1GKM A;  5EYT A;  3NZ4 A;  1FUQ A;  1FUP A;  2O7B A;  2HVG A;  3OCF A;  3UNV A;  3CZO A;  2RJR A;  2FUS A;  1EB4 A;  3GTD A;  4ADM A;  2E9F A;  4C5R A;  3KDZ A;  4NLE A;  1Y2M A;  2PTR A;  1AUW A;  1I0A A;  4EFC A;  1XWO A;  4CQ5 A;  1DCN A;  2VD6 A;  5F91 A;  1W27 A;  4V2Q A;  1GKJ A;  1C3U A;  1HY1 A;  1U16 A;  3NO9 A;  5F92 A;  4NSL A;  4FFX A;  2NYF A;  2PFM A;  1TJW A;  4C5U A;  2RJS A;  1HY0 A;  2NYN A;  4APA A;  3C8T A;  2PTS A;  2O6Y A;  3RD8 A;  1B8F A;  4V2R A;  1RE5 A;  1TJ7 A;  1JSW A;  3R6Q A;  4BAA A;  1YFE A;  1KQ7 A;  3R6V A;  2O7E A;  1TJV A;  4HGV A;  2PTQ A;  5EYV A;  1FUR A;  5HW2 A;  2O7F A;  1TJU A;  5D6B A;  2O7D A;  4C5S A;  1K62 A;  3TV2 A;  4EEI A;  4C6G A;  1FUO A;  2YII A;  4FLC A;  4MX2 A;  3R6Y A;  1K7W A;  2X75 A;  3KDY A; 
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