2O7EA

Tyrosine ammonia-lyase from rhodobacter sphaeroides (his89phe variant), bound to 2-aminoindan-2-phosphonic acid
Total Genus 191
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
191
sequence length
515
structure length
514
Chain Sequence
PKPAVELDRHIDLDQAHAVASGGARIVLAPPARDRCRASEARLGAVIREARHVYGLTTGFGPLANRLISGENVRTLQANLVHFLASGVGPVLDWTTARAMVLARLVSIAQGASGASEGTIARLIDLLNSELAPAVPSRGTVGDLTPLAHMVLCLQGRGDFLDRDGTRLDGAEGLRRGRLQPLDLSHRDALALVNGTSAMTGIALVNAHACRHLGNWAVALTALLAECLRGRTEAWAAALSDLRPHPGQKDAAARLRARVDGSARVVRHVIAERRLDAGDIGTEPEAGQDAYSLRCAPQVLGAGFDTLAWHDRVLTIELNAVTDNPVFPPDGSVPALHGGNFMGQHVALTSDALATAVTVLAGLAERQIARLTDERLNRGLPPFLHRGPAGLNSGFMGAQVTATALLAEMRATGPASIHSISTNAANQDVVSLGTIAARLCREKIDRWAEILAILALCLAQAAELRCGSGLDGVSPAGKKLVQALREQFPPLETDRPLGQEIAALATHLLQQSPV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases.
pubmed doi rcsb
source organism Rhodobacter sphaeroides
molecule tags Lyase
molecule keywords Putative histidine ammonia-lyase
total genus 191
structure length 514
sequence length 515
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 4.3.1.23: Tyrosine ammonia-lyase.
pdb deposition date 2006-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2o7eA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2o7eA02
2VD6A 1FUPA 4CQ5A 4NLEA 2PTQA 1JSWA 5D6BA 2YIIA 5EYVA 1TJWA 1FUQA 2PTRA 3RRPA 2RJSA 2RJRA 3NZ4A 5EYTA 1DOFA 1Y2MA 1GK2A 1GKMA 2NYNA 2NYFA 2O7EA 1T6JA 1KQ7A 1Q5NA 1VDKA 3RD8A 4C6GA 1YFEA 5HW2A 4ADLA 1J3UA 1U16A 4ADMA 3QBPA 3OCEA 4C5SA 3R6VA 4V2RA 1YFMA 2HVGA 4BABA 2OHYA 3R6YA 3C8TA 2PFMA 3KDZA 1B8FA 4NSLA 1XWOA 1EB4A 1GKJA 1TJVA 1DCNA 1FURA 3CZOA 1U15A 4C5UA 4APBA 1C3UA 2O7FA 3TV2A 1AUWA 4EFCA 3KDYA 4FLCA 1RE5A 1W27A 4BAAA 1HY0A 1GK3A 2X75A 2E9FA 1TJ7A 4EEIA 1T6PA 1C3CA 1I0AA 1HY1A 1K7WA 2O7BA 4FFXA 3GZHA 2PTSA 5F92A 4HGVA 1FUOA 4V2QA 3R6QA 1K62A 2FUSA 2QGAB 4C5RA 1YISA 4APAA 3E04A 2J91A 3GTDA 3UNVA 1TJUA 3BHGA 2QVEA 2O78A 5F91A 4MX2A 2O6YA 3NO9A 2O7DA 3OCFA
chains in the Genus database with same CATH superfamily
2VD6A 1FUPA 4CQ5A 4WNLA 4NLEA 2PTQA 1JSWA 5D6BA 2YIIA 5EYVA 1TJWA 1FUQA 2PTRA 3RRPA 2RJSA 2RJRA 2VSFA 5M0IA 3NZ4A 5EYTA 1DOFA 1Y2MA 1GK2A 1GKMA 2NYNA 2NYFA 2O7EA 1T6JA 1KQ7A 1Q5NA 1VDKA 3RD8A 4C6GA 1YFEA 5HW2A 4ADLA 1J3UA 3CRW1 1U16A 4ADMA 3QBPA 3OCEA 4C5SA 3R6VA 4V2RA 1YFMA 2HVGA 4BABA 2OHYA 2FELA 3R6YA 3C8TA 2PFMA 3KDZA 1B8FA 4A15A 4NSLA 1XWOA 1EB4A 1GKJA 1TJVA 1XMDA 1DCNA 1FURA 3CZOA 1U15A 4C5UA 5H8WA 4APBA 1C3UA 5M0JA 2O7FA 3TV2A 2VL7A 1XMCA 2FENA 1AUWA 4EFCA 3KDYA 4FLCA 1RE5A 1W27A 4BAAA 1HY0A 1GK3A 1XLYA 2X75A 3CRVA 2E9FA 1XL7A 1TJ7A 4EEIA 1T6PA 1C3CA 1I0AA 1HY1A 1K7WA 2O7BA 4FFXA 3GZHA 2PTSA 5F92A 4HGVA 1FUOA 4V2QA 3R6QA 1K62A 2FUSA 2QGAB 1XL8A 4C5RA 1YISA 4APAA 3E04A 2J91A 3GTDA 3UNVA 1TJUA 3BHGA 2QVEA 2O78A 5F91A 4MX2A 2O6YA 3NO9A 2O7DA 3OCFA
chains in the Genus database with same CATH topology
2VD6A 1FUPA 4CQ5A 4NLEA 2PTQA 1JSWA 5D6BA 2YIIA 5EYVA 1TJWA 1FUQA 2PTRA 3RRPA 2RJSA 2RJRA 3NZ4A 5EYTA 1DOFA 1Y2MA 1GK2A 1GKMA 2NYNA 2NYFA 2O7EA 1T6JA 1KQ7A 1Q5NA 1VDKA 3RD8A 4C6GA 1YFEA 5HW2A 4ADLA 1J3UA 1U16A 4ADMA 3QBPA 3OCEA 4C5SA 3R6VA 4V2RA 1YFMA 2HVGA 4BABA 2OHYA 3R6YA 3C8TA 2PFMA 3KDZA 1B8FA 4NSLA 1XWOA 1EB4A 1GKJA 1TJVA 1DCNA 1FURA 3CZOA 1U15A 4C5UA 4APBA 1C3UA 2O7FA 3TV2A 1AUWA 4EFCA 3KDYA 4FLCA 1RE5A 1W27A 4BAAA 1HY0A 1GK3A 2X75A 2E9FA 1TJ7A 4EEIA 1T6PA 1C3CA 1I0AA 1HY1A 1K7WA 2O7BA 4FFXA 3GZHA 2PTSA 5F92A 4HGVA 1FUOA 4V2QA 3R6QA 1K62A 2FUSA 2QGAB 4C5RA 1YISA 4APAA 3E04A 2J91A 3GTDA 3UNVA 1TJUA 3BHGA 2QVEA 2O78A 5F91A 4MX2A 2O6YA 3NO9A 2O7DA 3OCFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VD6 A;  1FUP A;  4CQ5 A;  4NLE A;  2PTQ A;  1JSW A;  5D6B A;  2YII A;  5EYV A;  1TJW A;  1FUQ A;  2PTR A;  3RRP A;  2RJS A;  2RJR A;  3NZ4 A;  5EYT A;  1DOF A;  1Y2M A;  1GK2 A;  1GKM A;  2NYN A;  2NYF A;  2O7E A;  1T6J A;  1KQ7 A;  1Q5N A;  1VDK A;  3RD8 A;  4C6G A;  1YFE A;  5HW2 A;  4ADL A;  1J3U A;  1U16 A;  4ADM A;  3QBP A;  3OCE A;  4C5S A;  3R6V A;  4V2R A;  1YFM A;  2HVG A;  4BAB A;  2OHY A;  3R6Y A;  3C8T A;  2PFM A;  3KDZ A;  1B8F A;  4NSL A;  1XWO A;  1EB4 A;  1GKJ A;  1TJV A;  1DCN A;  1FUR A;  3CZO A;  1U15 A;  4C5U A;  4APB A;  1C3U A;  2O7F A;  3TV2 A;  1AUW A;  4EFC A;  3KDY A;  4FLC A;  1RE5 A;  1W27 A;  4BAA A;  1HY0 A;  1GK3 A;  2X75 A;  2E9F A;  1TJ7 A;  4EEI A;  1T6P A;  1C3C A;  1I0A A;  1HY1 A;  1K7W A;  2O7B A;  4FFX A;  3GZH A;  2PTS A;  5F92 A;  4HGV A;  1FUO A;  4V2Q A;  3R6Q A;  1K62 A;  2FUS A;  2QGA B;  4C5R A;  1YIS A;  4APA A;  3E04 A;  2J91 A;  3GTD A;  3UNV A;  1TJU A;  3BHG A;  2QVE A;  2O78 A;  5F91 A;  4MX2 A;  2O6Y A;  3NO9 A;  2O7D A;  3OCF A; 
#chains in the Genus database with same CATH topology
 2VD6 A;  1FUP A;  4CQ5 A;  4WNL A;  4NLE A;  2PTQ A;  1JSW A;  5D6B A;  2YII A;  5EYV A;  1TJW A;  1FUQ A;  2PTR A;  3RRP A;  2RJS A;  2RJR A;  2VSF A;  5M0I A;  3NZ4 A;  5EYT A;  1DOF A;  1Y2M A;  1GK2 A;  1GKM A;  2NYN A;  2NYF A;  2O7E A;  1T6J A;  1KQ7 A;  1Q5N A;  1VDK A;  3RD8 A;  4C6G A;  1YFE A;  5HW2 A;  4ADL A;  1J3U A;  3CRW 1;  1U16 A;  4ADM A;  3QBP A;  3OCE A;  4C5S A;  3R6V A;  4V2R A;  1YFM A;  2HVG A;  4BAB A;  2OHY A;  2FEL A;  3R6Y A;  3C8T A;  2PFM A;  3KDZ A;  1B8F A;  4A15 A;  4NSL A;  1XWO A;  1EB4 A;  1GKJ A;  1TJV A;  1XMD A;  1DCN A;  1FUR A;  3CZO A;  1U15 A;  4C5U A;  5H8W A;  4APB A;  1C3U A;  5M0J A;  2O7F A;  3TV2 A;  2VL7 A;  1XMC A;  2FEN A;  1AUW A;  4EFC A;  3KDY A;  4FLC A;  1RE5 A;  1W27 A;  4BAA A;  1HY0 A;  1GK3 A;  1XLY A;  2X75 A;  3CRV A;  2E9F A;  1XL7 A;  1TJ7 A;  4EEI A;  1T6P A;  1C3C A;  1I0A A;  1HY1 A;  1K7W A;  2O7B A;  4FFX A;  3GZH A;  2PTS A;  5F92 A;  4HGV A;  1FUO A;  4V2Q A;  3R6Q A;  1K62 A;  2FUS A;  2QGA B;  1XL8 A;  4C5R A;  1YIS A;  4APA A;  3E04 A;  2J91 A;  3GTD A;  3UNV A;  1TJU A;  3BHG A;  2QVE A;  2O78 A;  5F91 A;  4MX2 A;  2O6Y A;  3NO9 A;  2O7D A;  3OCF A; 
#chains in the Genus database with same CATH homology
 2VD6 A;  1FUP A;  4CQ5 A;  4NLE A;  2PTQ A;  1JSW A;  5D6B A;  2YII A;  5EYV A;  1TJW A;  1FUQ A;  2PTR A;  3RRP A;  2RJS A;  2RJR A;  3NZ4 A;  5EYT A;  1DOF A;  1Y2M A;  1GK2 A;  1GKM A;  2NYN A;  2NYF A;  2O7E A;  1T6J A;  1KQ7 A;  1Q5N A;  1VDK A;  3RD8 A;  4C6G A;  1YFE A;  5HW2 A;  4ADL A;  1J3U A;  1U16 A;  4ADM A;  3QBP A;  3OCE A;  4C5S A;  3R6V A;  4V2R A;  1YFM A;  2HVG A;  4BAB A;  2OHY A;  3R6Y A;  3C8T A;  2PFM A;  3KDZ A;  1B8F A;  4NSL A;  1XWO A;  1EB4 A;  1GKJ A;  1TJV A;  1DCN A;  1FUR A;  3CZO A;  1U15 A;  4C5U A;  4APB A;  1C3U A;  2O7F A;  3TV2 A;  1AUW A;  4EFC A;  3KDY A;  4FLC A;  1RE5 A;  1W27 A;  4BAA A;  1HY0 A;  1GK3 A;  2X75 A;  2E9F A;  1TJ7 A;  4EEI A;  1T6P A;  1C3C A;  1I0A A;  1HY1 A;  1K7W A;  2O7B A;  4FFX A;  3GZH A;  2PTS A;  5F92 A;  4HGV A;  1FUO A;  4V2Q A;  3R6Q A;  1K62 A;  2FUS A;  2QGA B;  4C5R A;  1YIS A;  4APA A;  3E04 A;  2J91 A;  3GTD A;  3UNV A;  1TJU A;  3BHG A;  2QVE A;  2O78 A;  5F91 A;  4MX2 A;  2O6Y A;  3NO9 A;  2O7D A;  3OCF A; 
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