2O7EA

Tyrosine ammonia-lyase from rhodobacter sphaeroides (his89phe variant), bound to 2-aminoindan-2-phosphonic acid
Total Genus 191
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
191
sequence length
515
structure length
514
Chain Sequence
PKPAVELDRHIDLDQAHAVASGGARIVLAPPARDRCRASEARLGAVIREARHVYGLTTGFGPLANRLISGENVRTLQANLVHFLASGVGPVLDWTTARAMVLARLVSIAQGASGASEGTIARLIDLLNSELAPAVPSRGTVGDLTPLAHMVLCLQGRGDFLDRDGTRLDGAEGLRRGRLQPLDLSHRDALALVNGTSAMTGIALVNAHACRHLGNWAVALTALLAECLRGRTEAWAAALSDLRPHPGQKDAAARLRARVDGSARVVRHVIAERRLDAGDIGTEPEAGQDAYSLRCAPQVLGAGFDTLAWHDRVLTIELNAVTDNPVFPPDGSVPALHGGNFMGQHVALTSDALATAVTVLAGLAERQIARLTDERLNRGLPPFLHRGPAGLNSGFMGAQVTATALLAEMRATGPASIHSISTNAANQDVVSLGTIAARLCREKIDRWAEILAILALCLAQAAELRCGSGLDGVSPAGKKLVQALREQFPPLETDRPLGQEIAALATHLLQQSPV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Putative histidine ammonia-lyase
publication title Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases.
pubmed doi rcsb
source organism Rhodobacter sphaeroides
molecule tags Lyase
total genus 191
structure length 514
sequence length 515
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 4.3.1.23: Tyrosine ammonia-lyase.
pdb deposition date 2006-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2o7eA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2o7eA02
5F91A 1TJ7A 4EEIA 1YFMA 4NSLA 2NYNA 3R6QA 2J91A 1HY1A 3RD8A 1KQ7A 1DOFA 2PTSA 2O7EA 1FUQA 4APAA 3R6VA 2OHYA 1C3CA 5HW2A 1W27A 1I0AA 4EFCA 2RJSA 1Q5NA 4CQ5A 1GKMA 5D6BA 1AUWA 1RE5A 4ADLA 2O7BA 3NZ4A 4ADMA 3GTDA 4MX2A 1TJWA 1GK3A 2X75A 1T6PA 1C3UA 1YISA 3OCEA 4BAAA 1GKJA 1TJUA 3QBPA 1K7WA 4C6GA 4FFXA 4V2RA 3NO9A 2PTQA 3OCFA 2YIIA 3KDZA 2O7FA 2NYFA 3TV2A 1XWOA 2HVGA 5F92A 2O78A 2QVEA 1DCNA 1GK2A 4APBA 4FLCA 4NLEA 1Y2MA 5EYVA 1VDKA 1B8FA 1YFEA 3RRPA 1K62A 3R6YA 3KDYA 5EYTA 2PTRA 4BABA 1T6JA 3BHGA 4V2QA 3C8TA 3CZOA 1U16A 3UNVA 3E04A 4C5UA 4C5SA 1FURA 1J3UA 1TJVA 4C5RA 4HGVA 2O7DA 2FUSA 2PFMA 1JSWA 2VD6A 1FUPA 1HY0A 1U15A 2RJRA 1EB4A 2QGAB 2E9FA 3GZHA 2O6YA 1FUOA
chains in the Genus database with same CATH superfamily
4A15A 5F91A 1TJ7A 4EEIA 1YFMA 4NSLA 2NYNA 3R6QA 2J91A 1HY1A 3RD8A 1KQ7A 1DOFA 2PTSA 2O7EA 1FUQA 4APAA 3R6VA 2OHYA 1C3CA 5HW2A 1W27A 1I0AA 4EFCA 2RJSA 1Q5NA 4CQ5A 1GKMA 5D6BA 1AUWA 1RE5A 4ADLA 2O7BA 3NZ4A 4ADMA 3GTDA 4MX2A 1TJWA 1GK3A 2X75A 1T6PA 3CRW1 1C3UA 1XL7A 1YISA 3OCEA 4BAAA 1GKJA 1TJUA 3QBPA 1K7WA 5M0IA 4C6GA 4FFXA 4V2RA 3NO9A 2PTQA 3OCFA 2YIIA 3KDZA 2O7FA 2NYFA 3TV2A 1XWOA 2HVGA 5F92A 2O78A 2QVEA 1XL8A 1DCNA 5H8WA 1GK2A 4APBA 4FLCA 4NLEA 1Y2MA 5EYVA 1VDKA 4WNLA 1B8FA 1YFEA 2VSFA 3RRPA 1K62A 3R6YA 1XMCA 3KDYA 5EYTA 2PTRA 4BABA 2FELA 1XMDA 1T6JA 3BHGA 4V2QA 3C8TA 3CZOA 1U16A 3UNVA 3E04A 4C5UA 1XLYA 2VL7A 4C5SA 1FURA 1J3UA 1TJVA 4C5RA 4HGVA 2O7DA 2FUSA 2PFMA 3CRVA 1JSWA 2VD6A 1FUPA 1HY0A 1U15A 2RJRA 5M0JA 1EB4A 2QGAB 2E9FA 3GZHA 2O6YA 2FENA 1FUOA
chains in the Genus database with same CATH topology
5F91A 1TJ7A 4EEIA 1YFMA 4NSLA 2NYNA 3R6QA 2J91A 1HY1A 3RD8A 1KQ7A 1DOFA 2PTSA 2O7EA 1FUQA 4APAA 3R6VA 2OHYA 1C3CA 5HW2A 1W27A 1I0AA 4EFCA 2RJSA 1Q5NA 4CQ5A 1GKMA 5D6BA 1AUWA 1RE5A 4ADLA 2O7BA 3NZ4A 4ADMA 3GTDA 4MX2A 1TJWA 1GK3A 2X75A 1T6PA 1C3UA 1YISA 3OCEA 4BAAA 1GKJA 1TJUA 3QBPA 1K7WA 4C6GA 4FFXA 4V2RA 3NO9A 2PTQA 3OCFA 2YIIA 3KDZA 2O7FA 2NYFA 3TV2A 1XWOA 2HVGA 5F92A 2O78A 2QVEA 1DCNA 1GK2A 4APBA 4FLCA 4NLEA 1Y2MA 5EYVA 1VDKA 1B8FA 1YFEA 3RRPA 1K62A 3R6YA 3KDYA 5EYTA 2PTRA 4BABA 1T6JA 3BHGA 4V2QA 3C8TA 3CZOA 1U16A 3UNVA 3E04A 4C5UA 4C5SA 1FURA 1J3UA 1TJVA 4C5RA 4HGVA 2O7DA 2FUSA 2PFMA 1JSWA 2VD6A 1FUPA 1HY0A 1U15A 2RJRA 1EB4A 2QGAB 2E9FA 3GZHA 2O6YA 1FUOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5F91 A;  1TJ7 A;  4EEI A;  1YFM A;  4NSL A;  2NYN A;  3R6Q A;  2J91 A;  1HY1 A;  3RD8 A;  1KQ7 A;  1DOF A;  2PTS A;  2O7E A;  1FUQ A;  4APA A;  3R6V A;  2OHY A;  1C3C A;  5HW2 A;  1W27 A;  1I0A A;  4EFC A;  2RJS A;  1Q5N A;  4CQ5 A;  1GKM A;  5D6B A;  1AUW A;  1RE5 A;  4ADL A;  2O7B A;  3NZ4 A;  4ADM A;  3GTD A;  4MX2 A;  1TJW A;  1GK3 A;  2X75 A;  1T6P A;  1C3U A;  1YIS A;  3OCE A;  4BAA A;  1GKJ A;  1TJU A;  3QBP A;  1K7W A;  4C6G A;  4FFX A;  4V2R A;  3NO9 A;  2PTQ A;  3OCF A;  2YII A;  3KDZ A;  2O7F A;  2NYF A;  3TV2 A;  1XWO A;  2HVG A;  5F92 A;  2O78 A;  2QVE A;  1DCN A;  1GK2 A;  4APB A;  4FLC A;  4NLE A;  1Y2M A;  5EYV A;  1VDK A;  1B8F A;  1YFE A;  3RRP A;  1K62 A;  3R6Y A;  3KDY A;  5EYT A;  2PTR A;  4BAB A;  1T6J A;  3BHG A;  4V2Q A;  3C8T A;  3CZO A;  1U16 A;  3UNV A;  3E04 A;  4C5U A;  4C5S A;  1FUR A;  1J3U A;  1TJV A;  4C5R A;  4HGV A;  2O7D A;  2FUS A;  2PFM A;  1JSW A;  2VD6 A;  1FUP A;  1HY0 A;  1U15 A;  2RJR A;  1EB4 A;  2QGA B;  2E9F A;  3GZH A;  2O6Y A;  1FUO A; 
#chains in the Genus database with same CATH topology
 4A15 A;  5F91 A;  1TJ7 A;  4EEI A;  1YFM A;  4NSL A;  2NYN A;  3R6Q A;  2J91 A;  1HY1 A;  3RD8 A;  1KQ7 A;  1DOF A;  2PTS A;  2O7E A;  1FUQ A;  4APA A;  3R6V A;  2OHY A;  1C3C A;  5HW2 A;  1W27 A;  1I0A A;  4EFC A;  2RJS A;  1Q5N A;  4CQ5 A;  1GKM A;  5D6B A;  1AUW A;  1RE5 A;  4ADL A;  2O7B A;  3NZ4 A;  4ADM A;  3GTD A;  4MX2 A;  1TJW A;  1GK3 A;  2X75 A;  1T6P A;  3CRW 1;  1C3U A;  1XL7 A;  1YIS A;  3OCE A;  4BAA A;  1GKJ A;  1TJU A;  3QBP A;  1K7W A;  5M0I A;  4C6G A;  4FFX A;  4V2R A;  3NO9 A;  2PTQ A;  3OCF A;  2YII A;  3KDZ A;  2O7F A;  2NYF A;  3TV2 A;  1XWO A;  2HVG A;  5F92 A;  2O78 A;  2QVE A;  1XL8 A;  1DCN A;  5H8W A;  1GK2 A;  4APB A;  4FLC A;  4NLE A;  1Y2M A;  5EYV A;  1VDK A;  4WNL A;  1B8F A;  1YFE A;  2VSF A;  3RRP A;  1K62 A;  3R6Y A;  1XMC A;  3KDY A;  5EYT A;  2PTR A;  4BAB A;  2FEL A;  1XMD A;  1T6J A;  3BHG A;  4V2Q A;  3C8T A;  3CZO A;  1U16 A;  3UNV A;  3E04 A;  4C5U A;  1XLY A;  2VL7 A;  4C5S A;  1FUR A;  1J3U A;  1TJV A;  4C5R A;  4HGV A;  2O7D A;  2FUS A;  2PFM A;  3CRV A;  1JSW A;  2VD6 A;  1FUP A;  1HY0 A;  1U15 A;  2RJR A;  5M0J A;  1EB4 A;  2QGA B;  2E9F A;  3GZH A;  2O6Y A;  2FEN A;  1FUO A; 
#chains in the Genus database with same CATH homology
 5F91 A;  1TJ7 A;  4EEI A;  1YFM A;  4NSL A;  2NYN A;  3R6Q A;  2J91 A;  1HY1 A;  3RD8 A;  1KQ7 A;  1DOF A;  2PTS A;  2O7E A;  1FUQ A;  4APA A;  3R6V A;  2OHY A;  1C3C A;  5HW2 A;  1W27 A;  1I0A A;  4EFC A;  2RJS A;  1Q5N A;  4CQ5 A;  1GKM A;  5D6B A;  1AUW A;  1RE5 A;  4ADL A;  2O7B A;  3NZ4 A;  4ADM A;  3GTD A;  4MX2 A;  1TJW A;  1GK3 A;  2X75 A;  1T6P A;  1C3U A;  1YIS A;  3OCE A;  4BAA A;  1GKJ A;  1TJU A;  3QBP A;  1K7W A;  4C6G A;  4FFX A;  4V2R A;  3NO9 A;  2PTQ A;  3OCF A;  2YII A;  3KDZ A;  2O7F A;  2NYF A;  3TV2 A;  1XWO A;  2HVG A;  5F92 A;  2O78 A;  2QVE A;  1DCN A;  1GK2 A;  4APB A;  4FLC A;  4NLE A;  1Y2M A;  5EYV A;  1VDK A;  1B8F A;  1YFE A;  3RRP A;  1K62 A;  3R6Y A;  3KDY A;  5EYT A;  2PTR A;  4BAB A;  1T6J A;  3BHG A;  4V2Q A;  3C8T A;  3CZO A;  1U16 A;  3UNV A;  3E04 A;  4C5U A;  4C5S A;  1FUR A;  1J3U A;  1TJV A;  4C5R A;  4HGV A;  2O7D A;  2FUS A;  2PFM A;  1JSW A;  2VD6 A;  1FUP A;  1HY0 A;  1U15 A;  2RJR A;  1EB4 A;  2QGA B;  2E9F A;  3GZH A;  2O6Y A;  1FUO A; 
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