2O7EA

Tyrosine ammonia-lyase from rhodobacter sphaeroides (his89phe variant), bound to 2-aminoindan-2-phosphonic acid
Total Genus 191
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
191
sequence length
515
structure length
514
Chain Sequence
PKPAVELDRHIDLDQAHAVASGGARIVLAPPARDRCRASEARLGAVIREARHVYGLTTGFGPLANRLISGENVRTLQANLVHFLASGVGPVLDWTTARAMVLARLVSIAQGASGASEGTIARLIDLLNSELAPAVPSRGTVGDLTPLAHMVLCLQGRGDFLDRDGTRLDGAEGLRRGRLQPLDLSHRDALALVNGTSAMTGIALVNAHACRHLGNWAVALTALLAECLRGRTEAWAAALSDLRPHPGQKDAAARLRARVDGSARVVRHVIAERRLDAGDIGTEPEAGQDAYSLRCAPQVLGAGFDTLAWHDRVLTIELNAVTDNPVFPPDGSVPALHGGNFMGQHVALTSDALATAVTVLAGLAERQIARLTDERLNRGLPPFLHRGPAGLNSGFMGAQVTATALLAEMRATGPASIHSISTNAANQDVVSLGTIAARLCREKIDRWAEILAILALCLAQAAELRCGSGLDGVSPAGKKLVQALREQFPPLETDRPLGQEIAALATHLLQQSPV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lyase
molecule keywords Putative histidine ammonia-lyase
publication title Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases.
pubmed doi rcsb
source organism Rhodobacter sphaeroides
total genus 191
structure length 514
sequence length 515
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 4.3.1.23: Tyrosine ammonia-lyase.
pdb deposition date 2006-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2o7eA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2o7eA02
1FUOA 4BAAA 3R6YA 3RD8A 1C3CA 2HVGA 1FURA 1W27A 1Y2MA 2OHYA 3CZOA 4ADLA 2O7FA 4C5RA 1B8FA 3C8TA 5D6BA 1U15A 2NYFA 3GZHA 4V2RA 1T6JA 4BABA 1DOFA 1T6PA 1YISA 3E04A 1DCNA 1TJUA 2VD6A 1JSWA 4CQ5A 1K62A 1RE5A 2O7DA 2PTQA 1TJ7A 3R6VA 1K7WA 3TV2A 1VDKA 1TJVA 2PFMA 1FUQA 3UNVA 1GKJA 4MX2A 1GK2A 3OCFA 2PTRA 2J91A 4FLCA 3R6QA 5EYVA 3RRPA 4C5UA 2O7EA 1GK3A 2O6YA 3NO9A 2NYNA 4FFXA 4NSLA 1EB4A 2PTSA 1C3UA 1YFEA 2QVEA 4APAA 5F91A 1TJWA 2FUSA 4ADMA 3OCEA 2O78A 5EYTA 2RJRA 4NLEA 5HW2A 1GKMA 4HGVA 4EEIA 1FUPA 3QBPA 3KDZA 1YFMA 2X75A 4C5SA 1Q5NA 1J3UA 1I0AA 2RJSA 1U16A 4V2QA 1AUWA 5F92A 1XWOA 3NZ4A 2QGAB 1KQ7A 1HY0A 1HY1A 2YIIA 4APBA 4EFCA 4C6GA 2E9FA 3BHGA 3GTDA 2O7BA 3KDYA
chains in the Genus database with same CATH superfamily
1FUOA 4BAAA 2FELA 3CRW1 3R6YA 3RD8A 1C3CA 2HVGA 1FURA 2FENA 4WNLA 1W27A 1Y2MA 2OHYA 3CZOA 4ADLA 2O7FA 2VSFA 4C5RA 1B8FA 1XL7A 1XMCA 3C8TA 2VL7A 5M0IA 5D6BA 1U15A 2NYFA 3GZHA 4V2RA 1T6JA 4BABA 1DOFA 1T6PA 1YISA 3E04A 1DCNA 1TJUA 2VD6A 1JSWA 4CQ5A 1K62A 1RE5A 2O7DA 2PTQA 1TJ7A 3R6VA 1K7WA 3TV2A 1VDKA 1TJVA 2PFMA 3CRVA 1FUQA 3UNVA 1GKJA 4MX2A 1GK2A 3OCFA 2PTRA 2J91A 4FLCA 3R6QA 5EYVA 3RRPA 4C5UA 2O7EA 1GK3A 2O6YA 3NO9A 2NYNA 4FFXA 4NSLA 1EB4A 2PTSA 1C3UA 1YFEA 2QVEA 4APAA 5F91A 1TJWA 2FUSA 4ADMA 3OCEA 2O78A 5EYTA 2RJRA 4NLEA 1XL8A 5HW2A 1GKMA 4A15A 4HGVA 4EEIA 1FUPA 3QBPA 3KDZA 1YFMA 2X75A 1XMDA 4C5SA 1Q5NA 1J3UA 1I0AA 2RJSA 1U16A 5M0JA 4V2QA 1AUWA 5F92A 1XWOA 3NZ4A 1XLYA 2QGAB 1KQ7A 1HY0A 1HY1A 2YIIA 4APBA 4EFCA 4C6GA 2E9FA 3BHGA 5H8WA 3GTDA 2O7BA 3KDYA
chains in the Genus database with same CATH topology
1FUOA 4BAAA 3R6YA 3RD8A 1C3CA 2HVGA 1FURA 1W27A 1Y2MA 2OHYA 3CZOA 4ADLA 2O7FA 4C5RA 1B8FA 3C8TA 5D6BA 1U15A 2NYFA 3GZHA 4V2RA 1T6JA 4BABA 1DOFA 1T6PA 1YISA 3E04A 1DCNA 1TJUA 2VD6A 1JSWA 4CQ5A 1K62A 1RE5A 2O7DA 2PTQA 1TJ7A 3R6VA 1K7WA 3TV2A 1VDKA 1TJVA 2PFMA 1FUQA 3UNVA 1GKJA 4MX2A 1GK2A 3OCFA 2PTRA 2J91A 4FLCA 3R6QA 5EYVA 3RRPA 4C5UA 2O7EA 1GK3A 2O6YA 3NO9A 2NYNA 4FFXA 4NSLA 1EB4A 2PTSA 1C3UA 1YFEA 2QVEA 4APAA 5F91A 1TJWA 2FUSA 4ADMA 3OCEA 2O78A 5EYTA 2RJRA 4NLEA 5HW2A 1GKMA 4HGVA 4EEIA 1FUPA 3QBPA 3KDZA 1YFMA 2X75A 4C5SA 1Q5NA 1J3UA 1I0AA 2RJSA 1U16A 4V2QA 1AUWA 5F92A 1XWOA 3NZ4A 2QGAB 1KQ7A 1HY0A 1HY1A 2YIIA 4APBA 4EFCA 4C6GA 2E9FA 3BHGA 3GTDA 2O7BA 3KDYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FUO A;  4BAA A;  3R6Y A;  3RD8 A;  1C3C A;  2HVG A;  1FUR A;  1W27 A;  1Y2M A;  2OHY A;  3CZO A;  4ADL A;  2O7F A;  4C5R A;  1B8F A;  3C8T A;  5D6B A;  1U15 A;  2NYF A;  3GZH A;  4V2R A;  1T6J A;  4BAB A;  1DOF A;  1T6P A;  1YIS A;  3E04 A;  1DCN A;  1TJU A;  2VD6 A;  1JSW A;  4CQ5 A;  1K62 A;  1RE5 A;  2O7D A;  2PTQ A;  1TJ7 A;  3R6V A;  1K7W A;  3TV2 A;  1VDK A;  1TJV A;  2PFM A;  1FUQ A;  3UNV A;  1GKJ A;  4MX2 A;  1GK2 A;  3OCF A;  2PTR A;  2J91 A;  4FLC A;  3R6Q A;  5EYV A;  3RRP A;  4C5U A;  2O7E A;  1GK3 A;  2O6Y A;  3NO9 A;  2NYN A;  4FFX A;  4NSL A;  1EB4 A;  2PTS A;  1C3U A;  1YFE A;  2QVE A;  4APA A;  5F91 A;  1TJW A;  2FUS A;  4ADM A;  3OCE A;  2O78 A;  5EYT A;  2RJR A;  4NLE A;  5HW2 A;  1GKM A;  4HGV A;  4EEI A;  1FUP A;  3QBP A;  3KDZ A;  1YFM A;  2X75 A;  4C5S A;  1Q5N A;  1J3U A;  1I0A A;  2RJS A;  1U16 A;  4V2Q A;  1AUW A;  5F92 A;  1XWO A;  3NZ4 A;  2QGA B;  1KQ7 A;  1HY0 A;  1HY1 A;  2YII A;  4APB A;  4EFC A;  4C6G A;  2E9F A;  3BHG A;  3GTD A;  2O7B A;  3KDY A; 
#chains in the Genus database with same CATH topology
 1FUO A;  4BAA A;  2FEL A;  3CRW 1;  3R6Y A;  3RD8 A;  1C3C A;  2HVG A;  1FUR A;  2FEN A;  4WNL A;  1W27 A;  1Y2M A;  2OHY A;  3CZO A;  4ADL A;  2O7F A;  2VSF A;  4C5R A;  1B8F A;  1XL7 A;  1XMC A;  3C8T A;  2VL7 A;  5M0I A;  5D6B A;  1U15 A;  2NYF A;  3GZH A;  4V2R A;  1T6J A;  4BAB A;  1DOF A;  1T6P A;  1YIS A;  3E04 A;  1DCN A;  1TJU A;  2VD6 A;  1JSW A;  4CQ5 A;  1K62 A;  1RE5 A;  2O7D A;  2PTQ A;  1TJ7 A;  3R6V A;  1K7W A;  3TV2 A;  1VDK A;  1TJV A;  2PFM A;  3CRV A;  1FUQ A;  3UNV A;  1GKJ A;  4MX2 A;  1GK2 A;  3OCF A;  2PTR A;  2J91 A;  4FLC A;  3R6Q A;  5EYV A;  3RRP A;  4C5U A;  2O7E A;  1GK3 A;  2O6Y A;  3NO9 A;  2NYN A;  4FFX A;  4NSL A;  1EB4 A;  2PTS A;  1C3U A;  1YFE A;  2QVE A;  4APA A;  5F91 A;  1TJW A;  2FUS A;  4ADM A;  3OCE A;  2O78 A;  5EYT A;  2RJR A;  4NLE A;  1XL8 A;  5HW2 A;  1GKM A;  4A15 A;  4HGV A;  4EEI A;  1FUP A;  3QBP A;  3KDZ A;  1YFM A;  2X75 A;  1XMD A;  4C5S A;  1Q5N A;  1J3U A;  1I0A A;  2RJS A;  1U16 A;  5M0J A;  4V2Q A;  1AUW A;  5F92 A;  1XWO A;  3NZ4 A;  1XLY A;  2QGA B;  1KQ7 A;  1HY0 A;  1HY1 A;  2YII A;  4APB A;  4EFC A;  4C6G A;  2E9F A;  3BHG A;  5H8W A;  3GTD A;  2O7B A;  3KDY A; 
#chains in the Genus database with same CATH homology
 1FUO A;  4BAA A;  3R6Y A;  3RD8 A;  1C3C A;  2HVG A;  1FUR A;  1W27 A;  1Y2M A;  2OHY A;  3CZO A;  4ADL A;  2O7F A;  4C5R A;  1B8F A;  3C8T A;  5D6B A;  1U15 A;  2NYF A;  3GZH A;  4V2R A;  1T6J A;  4BAB A;  1DOF A;  1T6P A;  1YIS A;  3E04 A;  1DCN A;  1TJU A;  2VD6 A;  1JSW A;  4CQ5 A;  1K62 A;  1RE5 A;  2O7D A;  2PTQ A;  1TJ7 A;  3R6V A;  1K7W A;  3TV2 A;  1VDK A;  1TJV A;  2PFM A;  1FUQ A;  3UNV A;  1GKJ A;  4MX2 A;  1GK2 A;  3OCF A;  2PTR A;  2J91 A;  4FLC A;  3R6Q A;  5EYV A;  3RRP A;  4C5U A;  2O7E A;  1GK3 A;  2O6Y A;  3NO9 A;  2NYN A;  4FFX A;  4NSL A;  1EB4 A;  2PTS A;  1C3U A;  1YFE A;  2QVE A;  4APA A;  5F91 A;  1TJW A;  2FUS A;  4ADM A;  3OCE A;  2O78 A;  5EYT A;  2RJR A;  4NLE A;  5HW2 A;  1GKM A;  4HGV A;  4EEI A;  1FUP A;  3QBP A;  3KDZ A;  1YFM A;  2X75 A;  4C5S A;  1Q5N A;  1J3U A;  1I0A A;  2RJS A;  1U16 A;  4V2Q A;  1AUW A;  5F92 A;  1XWO A;  3NZ4 A;  2QGA B;  1KQ7 A;  1HY0 A;  1HY1 A;  2YII A;  4APB A;  4EFC A;  4C6G A;  2E9F A;  3BHG A;  3GTD A;  2O7B A;  3KDY A; 
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