2O7EA

Tyrosine ammonia-lyase from rhodobacter sphaeroides (his89phe variant), bound to 2-aminoindan-2-phosphonic acid
Total Genus 191
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
191
sequence length
515
structure length
514
Chain Sequence
PKPAVELDRHIDLDQAHAVASGGARIVLAPPARDRCRASEARLGAVIREARHVYGLTTGFGPLANRLISGENVRTLQANLVHFLASGVGPVLDWTTARAMVLARLVSIAQGASGASEGTIARLIDLLNSELAPAVPSRGTVGDLTPLAHMVLCLQGRGDFLDRDGTRLDGAEGLRRGRLQPLDLSHRDALALVNGTSAMTGIALVNAHACRHLGNWAVALTALLAECLRGRTEAWAAALSDLRPHPGQKDAAARLRARVDGSARVVRHVIAERRLDAGDIGTEPEAGQDAYSLRCAPQVLGAGFDTLAWHDRVLTIELNAVTDNPVFPPDGSVPALHGGNFMGQHVALTSDALATAVTVLAGLAERQIARLTDERLNRGLPPFLHRGPAGLNSGFMGAQVTATALLAEMRATGPASIHSISTNAANQDVVSLGTIAARLCREKIDRWAEILAILALCLAQAAELRCGSGLDGVSPAGKKLVQALREQFPPLETDRPLGQEIAALATHLLQQSPV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases.
pubmed doi rcsb
source organism Rhodobacter sphaeroides
molecule tags Lyase
molecule keywords Putative histidine ammonia-lyase
total genus 191
structure length 514
sequence length 515
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 4.3.1.23: Tyrosine ammonia-lyase.
pdb deposition date 2006-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2o7eA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2o7eA02
1HY1A 4ADMA 2J91A 4V2RA 2HVGA 3CZOA 1J3UA 3C8TA 3KDZA 1B8FA 2QGAB 4BAAA 3OCEA 4BABA 5EYTA 3RD8A 2VD6A 2PFMA 1JSWA 4NLEA 1Y2MA 4APBA 1K62A 1I0AA 1AUWA 5D6BA 4EFCA 1T6PA 2PTQA 4NSLA 2OHYA 3E04A 1FURA 1FUOA 1RE5A 3GTDA 3R6YA 1VDKA 3NO9A 2NYNA 1T6JA 1YFMA 4EEIA 4C5UA 4CQ5A 1YFEA 1GKJA 1TJ7A 2X75A 3TV2A 1HY0A 2FUSA 1U15A 3OCFA 2O6YA 5F92A 1U16A 1Q5NA 3QBPA 1K7WA 4APAA 1TJVA 1EB4A 1KQ7A 1DOFA 2NYFA 4C6GA 2PTSA 1XWOA 3R6VA 1GK2A 1YISA 4FFXA 3BHGA 3R6QA 5EYVA 2O7DA 4FLCA 1C3UA 2QVEA 4V2QA 1DCNA 4HGVA 5F91A 4ADLA 2YIIA 2RJRA 4C5RA 4MX2A 3GZHA 1FUPA 3KDYA 3NZ4A 3RRPA 1C3CA 1TJWA 1GK3A 1W27A 2O7EA 1TJUA 2O7FA 2PTRA 2O78A 1FUQA 4C5SA 2O7BA 2E9FA 1GKMA 2RJSA 5HW2A 3UNVA
chains in the Genus database with same CATH superfamily
1HY1A 2FENA 4ADMA 2J91A 4V2RA 2HVGA 3CZOA 1J3UA 3C8TA 3KDZA 1B8FA 2QGAB 4BAAA 3OCEA 1XMCA 4BABA 5EYTA 3RD8A 2VD6A 2PFMA 5M0IA 1JSWA 4NLEA 1Y2MA 4APBA 1K62A 1I0AA 1AUWA 5D6BA 4EFCA 1T6PA 2PTQA 4WNLA 4NSLA 2OHYA 3E04A 1FURA 1FUOA 1RE5A 3GTDA 3R6YA 1VDKA 3NO9A 5M0JA 2NYNA 1T6JA 1YFMA 5H8WA 4EEIA 4C5UA 4CQ5A 1XLYA 1YFEA 1XL8A 1GKJA 1TJ7A 2X75A 3TV2A 1HY0A 2FUSA 1U15A 3OCFA 2O6YA 5F92A 1U16A 1Q5NA 3QBPA 1K7WA 4APAA 1TJVA 1EB4A 1KQ7A 1DOFA 2NYFA 4C6GA 2PTSA 1XWOA 3R6VA 1XL7A 1GK2A 1YISA 4FFXA 2FELA 3BHGA 3R6QA 5EYVA 2O7DA 4FLCA 1C3UA 2QVEA 4V2QA 1DCNA 4HGVA 5F91A 4A15A 2VSFA 4ADLA 2YIIA 2RJRA 4C5RA 1XMDA 4MX2A 3GZHA 1FUPA 3KDYA 3NZ4A 3RRPA 1C3CA 3CRVA 1TJWA 1GK3A 1W27A 2O7EA 1TJUA 2O7FA 2PTRA 2O78A 3CRW1 3UNVA 1FUQA 4C5SA 2E9FA 2O7BA 1GKMA 2RJSA 5HW2A 2VL7A
chains in the Genus database with same CATH topology
1HY1A 4ADMA 2J91A 4V2RA 2HVGA 3CZOA 1J3UA 3C8TA 3KDZA 1B8FA 2QGAB 4BAAA 3OCEA 4BABA 5EYTA 3RD8A 2VD6A 2PFMA 1JSWA 4NLEA 1Y2MA 4APBA 1K62A 1I0AA 1AUWA 5D6BA 4EFCA 1T6PA 2PTQA 4NSLA 2OHYA 3E04A 1FURA 1FUOA 1RE5A 3GTDA 3R6YA 1VDKA 3NO9A 2NYNA 1T6JA 1YFMA 4EEIA 4C5UA 4CQ5A 1YFEA 1GKJA 1TJ7A 2X75A 3TV2A 1HY0A 2FUSA 1U15A 3OCFA 2O6YA 5F92A 1U16A 1Q5NA 3QBPA 1K7WA 4APAA 1TJVA 1EB4A 1KQ7A 1DOFA 2NYFA 4C6GA 2PTSA 1XWOA 3R6VA 1GK2A 1YISA 4FFXA 3BHGA 3R6QA 5EYVA 2O7DA 4FLCA 1C3UA 2QVEA 4V2QA 1DCNA 4HGVA 5F91A 4ADLA 2YIIA 2RJRA 4C5RA 4MX2A 3GZHA 1FUPA 3KDYA 3NZ4A 3RRPA 1C3CA 1TJWA 1GK3A 1W27A 2O7EA 1TJUA 2O7FA 2PTRA 2O78A 1FUQA 4C5SA 2O7BA 2E9FA 1GKMA 2RJSA 5HW2A 3UNVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HY1 A;  4ADM A;  2J91 A;  4V2R A;  2HVG A;  3CZO A;  1J3U A;  3C8T A;  3KDZ A;  1B8F A;  2QGA B;  4BAA A;  3OCE A;  4BAB A;  5EYT A;  3RD8 A;  2VD6 A;  2PFM A;  1JSW A;  4NLE A;  1Y2M A;  4APB A;  1K62 A;  1I0A A;  1AUW A;  5D6B A;  4EFC A;  1T6P A;  2PTQ A;  4NSL A;  2OHY A;  3E04 A;  1FUR A;  1FUO A;  1RE5 A;  3GTD A;  3R6Y A;  1VDK A;  3NO9 A;  2NYN A;  1T6J A;  1YFM A;  4EEI A;  4C5U A;  4CQ5 A;  1YFE A;  1GKJ A;  1TJ7 A;  2X75 A;  3TV2 A;  1HY0 A;  2FUS A;  1U15 A;  3OCF A;  2O6Y A;  5F92 A;  1U16 A;  1Q5N A;  3QBP A;  1K7W A;  4APA A;  1TJV A;  1EB4 A;  1KQ7 A;  1DOF A;  2NYF A;  4C6G A;  2PTS A;  1XWO A;  3R6V A;  1GK2 A;  1YIS A;  4FFX A;  3BHG A;  3R6Q A;  5EYV A;  2O7D A;  4FLC A;  1C3U A;  2QVE A;  4V2Q A;  1DCN A;  4HGV A;  5F91 A;  4ADL A;  2YII A;  2RJR A;  4C5R A;  4MX2 A;  3GZH A;  1FUP A;  3KDY A;  3NZ4 A;  3RRP A;  1C3C A;  1TJW A;  1GK3 A;  1W27 A;  2O7E A;  1TJU A;  2O7F A;  2PTR A;  2O78 A;  1FUQ A;  4C5S A;  2O7B A;  2E9F A;  1GKM A;  2RJS A;  5HW2 A;  3UNV A; 
#chains in the Genus database with same CATH topology
 1HY1 A;  2FEN A;  4ADM A;  2J91 A;  4V2R A;  2HVG A;  3CZO A;  1J3U A;  3C8T A;  3KDZ A;  1B8F A;  2QGA B;  4BAA A;  3OCE A;  1XMC A;  4BAB A;  5EYT A;  3RD8 A;  2VD6 A;  2PFM A;  5M0I A;  1JSW A;  4NLE A;  1Y2M A;  4APB A;  1K62 A;  1I0A A;  1AUW A;  5D6B A;  4EFC A;  1T6P A;  2PTQ A;  4WNL A;  4NSL A;  2OHY A;  3E04 A;  1FUR A;  1FUO A;  1RE5 A;  3GTD A;  3R6Y A;  1VDK A;  3NO9 A;  5M0J A;  2NYN A;  1T6J A;  1YFM A;  5H8W A;  4EEI A;  4C5U A;  4CQ5 A;  1XLY A;  1YFE A;  1XL8 A;  1GKJ A;  1TJ7 A;  2X75 A;  3TV2 A;  1HY0 A;  2FUS A;  1U15 A;  3OCF A;  2O6Y A;  5F92 A;  1U16 A;  1Q5N A;  3QBP A;  1K7W A;  4APA A;  1TJV A;  1EB4 A;  1KQ7 A;  1DOF A;  2NYF A;  4C6G A;  2PTS A;  1XWO A;  3R6V A;  1XL7 A;  1GK2 A;  1YIS A;  4FFX A;  2FEL A;  3BHG A;  3R6Q A;  5EYV A;  2O7D A;  4FLC A;  1C3U A;  2QVE A;  4V2Q A;  1DCN A;  4HGV A;  5F91 A;  4A15 A;  2VSF A;  4ADL A;  2YII A;  2RJR A;  4C5R A;  1XMD A;  4MX2 A;  3GZH A;  1FUP A;  3KDY A;  3NZ4 A;  3RRP A;  1C3C A;  3CRV A;  1TJW A;  1GK3 A;  1W27 A;  2O7E A;  1TJU A;  2O7F A;  2PTR A;  2O78 A;  3CRW 1;  3UNV A;  1FUQ A;  4C5S A;  2E9F A;  2O7B A;  1GKM A;  2RJS A;  5HW2 A;  2VL7 A; 
#chains in the Genus database with same CATH homology
 1HY1 A;  4ADM A;  2J91 A;  4V2R A;  2HVG A;  3CZO A;  1J3U A;  3C8T A;  3KDZ A;  1B8F A;  2QGA B;  4BAA A;  3OCE A;  4BAB A;  5EYT A;  3RD8 A;  2VD6 A;  2PFM A;  1JSW A;  4NLE A;  1Y2M A;  4APB A;  1K62 A;  1I0A A;  1AUW A;  5D6B A;  4EFC A;  1T6P A;  2PTQ A;  4NSL A;  2OHY A;  3E04 A;  1FUR A;  1FUO A;  1RE5 A;  3GTD A;  3R6Y A;  1VDK A;  3NO9 A;  2NYN A;  1T6J A;  1YFM A;  4EEI A;  4C5U A;  4CQ5 A;  1YFE A;  1GKJ A;  1TJ7 A;  2X75 A;  3TV2 A;  1HY0 A;  2FUS A;  1U15 A;  3OCF A;  2O6Y A;  5F92 A;  1U16 A;  1Q5N A;  3QBP A;  1K7W A;  4APA A;  1TJV A;  1EB4 A;  1KQ7 A;  1DOF A;  2NYF A;  4C6G A;  2PTS A;  1XWO A;  3R6V A;  1GK2 A;  1YIS A;  4FFX A;  3BHG A;  3R6Q A;  5EYV A;  2O7D A;  4FLC A;  1C3U A;  2QVE A;  4V2Q A;  1DCN A;  4HGV A;  5F91 A;  4ADL A;  2YII A;  2RJR A;  4C5R A;  4MX2 A;  3GZH A;  1FUP A;  3KDY A;  3NZ4 A;  3RRP A;  1C3C A;  1TJW A;  1GK3 A;  1W27 A;  2O7E A;  1TJU A;  2O7F A;  2PTR A;  2O78 A;  1FUQ A;  4C5S A;  2O7B A;  2E9F A;  1GKM A;  2RJS A;  5HW2 A;  3UNV A; 
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