2O7EA

Tyrosine ammonia-lyase from rhodobacter sphaeroides (his89phe variant), bound to 2-aminoindan-2-phosphonic acid
Total Genus 191
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
191
sequence length
515
structure length
514
Chain Sequence
b'PKPAVELDRHIDLDQAHAVASGGARIVLAPPARDRCRASEARLGAVIREARHVYGLTTGFGPLANRLISGENVRTLQANLVHFLASGVGPVLDWTTARAMVLARLVSIAQGASGASEGTIARLIDLLNSELAPAVPSRGTVGDLTPLAHMVLCLQGRGDFLDRDGTRLDGAEGLRRGRLQPLDLSHRDALALVNGTSAMTGIALVNAHACRHLGNWAVALTALLAECLRGRTEAWAAALSDLRPHPGQKDAAARLRARVDGSARVVRHVIAERRLDAGDIGTEPEAGQDAYSLRCAPQVLGAGFDTLAWHDRVLTIELNAVTDNPVFPPDGSVPALHGGNFMGQHVALTSDALATAVTVLAGLAERQIARLTDERLNRGLPPFLHRGPAGLNSGFMGAQVTATALLAEMRATGPASIHSISTNAANQDVVSLGTIAARLCREKIDRWAEILAILALCLAQAAELRCGSGLDGVSPAGKKLVQALREQFPPLETDRPLGQEIAALATHLLQQSPV'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Putative histidine ammonia-lyase
publication title Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases.
pubmed doi rcsb
source organism Rhodobacter sphaeroides
molecule tags Lyase
total genus 191
structure length 514
sequence length 515
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 4.3.1.23: Tyrosine ammonia-lyase.
pdb deposition date 2006-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2o7eA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2o7eA02
2NYNA 2RJRA 1I0AA 4BABA 4V2RA 1JSWA 2OHYA 4APAA 1RE5A 4CQ5A 1HY1A 1Q5NA 2PTQA 1K62A 4ADMA 4C6GA 1KQ7A 2PTSA 4EFCA 1GKJA 2YIIA 1VDKA 3R6VA 3E04A 4FLCA 2PFMA 4FFXA 5EYTA 4EEIA 2E9FA 1B8FA 4APBA 1GKMA 4V2QA 4C5RA 3R6QA 2O7EA 1Y2MA 1FUQA 5F92A 2O7DA 3KDZA 1T6PA 2J91A 1XWOA 3UNVA 5D6BA 3TV2A 2VD6A 1FUOA 1FUPA 2QGAB 1K7WA 1GK2A 3KDYA 3RD8A 2O6YA 4NSLA 1TJWA 2O78A 2QVEA 3QBPA 4C5SA 1U16A 1DOFA 3BHGA 1T6JA 4MX2A 3C8TA 1AUWA 1YISA 4NLEA 1C3CA 3RRPA 3R6YA 1TJVA 1DCNA 3OCEA 1EB4A 3GTDA 2O7FA 1J3UA 2NYFA 2O7BA 5EYVA 4HGVA 1GK3A 1FURA 3OCFA 4C5UA 1YFEA 3NZ4A 1YFMA 5F91A 3NO9A 2X75A 1TJ7A 4ADLA 2FUSA 2HVGA 1HY0A 1C3UA 1W27A 2PTRA 3GZHA 3CZOA 5HW2A 4BAAA 2RJSA 1U15A 1TJUA
chains in the Genus database with same CATH superfamily
2NYNA 1XMCA 2RJRA 5M0JA 1I0AA 4BABA 4WNLA 4V2RA 1JSWA 2OHYA 5H8WA 4APAA 1RE5A 4CQ5A 1HY1A 1Q5NA 2PTQA 3CRW1 1K62A 4ADMA 4C6GA 1KQ7A 2PTSA 4EFCA 1GKJA 2YIIA 1VDKA 3R6VA 3E04A 4FLCA 2E9FA 2PFMA 4FFXA 5EYTA 4EEIA 1B8FA 4APBA 2FENA 1GKMA 4V2QA 4C5RA 4A15A 1XLYA 1XL8A 3R6QA 2O7EA 1Y2MA 1FUQA 5F92A 2O7DA 2FELA 3KDZA 1T6PA 2J91A 1XWOA 3UNVA 5D6BA 3TV2A 2VD6A 1FUOA 1FUPA 2QGAB 1K7WA 3CRVA 1GK2A 3KDYA 3RD8A 2O6YA 4NSLA 1TJWA 2O78A 2QVEA 3QBPA 4C5SA 1U16A 1DOFA 3BHGA 5M0IA 1T6JA 4MX2A 3C8TA 1AUWA 1YISA 2VL7A 4NLEA 1C3CA 3RRPA 3R6YA 1TJVA 1DCNA 1EB4A 1XMDA 3OCEA 3GTDA 2O7FA 1J3UA 2NYFA 2O7BA 5EYVA 4HGVA 1GK3A 1FURA 3OCFA 4C5UA 1YFEA 3NZ4A 1YFMA 5F91A 3NO9A 2X75A 1TJ7A 4ADLA 2FUSA 2HVGA 1HY0A 1C3UA 1W27A 1XL7A 2PTRA 3GZHA 3CZOA 5HW2A 4BAAA 2VSFA 2RJSA 1U15A 1TJUA
chains in the Genus database with same CATH topology
2NYNA 2RJRA 1I0AA 4BABA 4V2RA 1JSWA 2OHYA 4APAA 1RE5A 4CQ5A 1HY1A 1Q5NA 2PTQA 1K62A 4ADMA 4C6GA 1KQ7A 2PTSA 4EFCA 1GKJA 2YIIA 1VDKA 3R6VA 3E04A 4FLCA 2PFMA 4FFXA 5EYTA 4EEIA 2E9FA 1B8FA 4APBA 1GKMA 4V2QA 4C5RA 3R6QA 2O7EA 1Y2MA 1FUQA 5F92A 2O7DA 3KDZA 1T6PA 2J91A 1XWOA 3UNVA 5D6BA 3TV2A 2VD6A 1FUOA 1FUPA 2QGAB 1K7WA 1GK2A 3KDYA 3RD8A 2O6YA 4NSLA 1TJWA 2O78A 2QVEA 3QBPA 4C5SA 1U16A 1DOFA 3BHGA 1T6JA 4MX2A 3C8TA 1AUWA 1YISA 4NLEA 1C3CA 3RRPA 3R6YA 1TJVA 1DCNA 3OCEA 1EB4A 3GTDA 2O7FA 1J3UA 2NYFA 2O7BA 5EYVA 4HGVA 1GK3A 1FURA 3OCFA 4C5UA 1YFEA 3NZ4A 1YFMA 5F91A 3NO9A 2X75A 1TJ7A 4ADLA 2FUSA 2HVGA 1HY0A 1C3UA 1W27A 2PTRA 3GZHA 3CZOA 5HW2A 4BAAA 2RJSA 1U15A 1TJUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NYN A;  2RJR A;  1I0A A;  4BAB A;  4V2R A;  1JSW A;  2OHY A;  4APA A;  1RE5 A;  4CQ5 A;  1HY1 A;  1Q5N A;  2PTQ A;  1K62 A;  4ADM A;  4C6G A;  1KQ7 A;  2PTS A;  4EFC A;  1GKJ A;  2YII A;  1VDK A;  3R6V A;  3E04 A;  4FLC A;  2PFM A;  4FFX A;  5EYT A;  4EEI A;  2E9F A;  1B8F A;  4APB A;  1GKM A;  4V2Q A;  4C5R A;  3R6Q A;  2O7E A;  1Y2M A;  1FUQ A;  5F92 A;  2O7D A;  3KDZ A;  1T6P A;  2J91 A;  1XWO A;  3UNV A;  5D6B A;  3TV2 A;  2VD6 A;  1FUO A;  1FUP A;  2QGA B;  1K7W A;  1GK2 A;  3KDY A;  3RD8 A;  2O6Y A;  4NSL A;  1TJW A;  2O78 A;  2QVE A;  3QBP A;  4C5S A;  1U16 A;  1DOF A;  3BHG A;  1T6J A;  4MX2 A;  3C8T A;  1AUW A;  1YIS A;  4NLE A;  1C3C A;  3RRP A;  3R6Y A;  1TJV A;  1DCN A;  3OCE A;  1EB4 A;  3GTD A;  2O7F A;  1J3U A;  2NYF A;  2O7B A;  5EYV A;  4HGV A;  1GK3 A;  1FUR A;  3OCF A;  4C5U A;  1YFE A;  3NZ4 A;  1YFM A;  5F91 A;  3NO9 A;  2X75 A;  1TJ7 A;  4ADL A;  2FUS A;  2HVG A;  1HY0 A;  1C3U A;  1W27 A;  2PTR A;  3GZH A;  3CZO A;  5HW2 A;  4BAA A;  2RJS A;  1U15 A;  1TJU A; 
#chains in the Genus database with same CATH topology
 2NYN A;  1XMC A;  2RJR A;  5M0J A;  1I0A A;  4BAB A;  4WNL A;  4V2R A;  1JSW A;  2OHY A;  5H8W A;  4APA A;  1RE5 A;  4CQ5 A;  1HY1 A;  1Q5N A;  2PTQ A;  3CRW 1;  1K62 A;  4ADM A;  4C6G A;  1KQ7 A;  2PTS A;  4EFC A;  1GKJ A;  2YII A;  1VDK A;  3R6V A;  3E04 A;  4FLC A;  2E9F A;  2PFM A;  4FFX A;  5EYT A;  4EEI A;  1B8F A;  4APB A;  2FEN A;  1GKM A;  4V2Q A;  4C5R A;  4A15 A;  1XLY A;  1XL8 A;  3R6Q A;  2O7E A;  1Y2M A;  1FUQ A;  5F92 A;  2O7D A;  2FEL A;  3KDZ A;  1T6P A;  2J91 A;  1XWO A;  3UNV A;  5D6B A;  3TV2 A;  2VD6 A;  1FUO A;  1FUP A;  2QGA B;  1K7W A;  3CRV A;  1GK2 A;  3KDY A;  3RD8 A;  2O6Y A;  4NSL A;  1TJW A;  2O78 A;  2QVE A;  3QBP A;  4C5S A;  1U16 A;  1DOF A;  3BHG A;  5M0I A;  1T6J A;  4MX2 A;  3C8T A;  1AUW A;  1YIS A;  2VL7 A;  4NLE A;  1C3C A;  3RRP A;  3R6Y A;  1TJV A;  1DCN A;  1EB4 A;  1XMD A;  3OCE A;  3GTD A;  2O7F A;  1J3U A;  2NYF A;  2O7B A;  5EYV A;  4HGV A;  1GK3 A;  1FUR A;  3OCF A;  4C5U A;  1YFE A;  3NZ4 A;  1YFM A;  5F91 A;  3NO9 A;  2X75 A;  1TJ7 A;  4ADL A;  2FUS A;  2HVG A;  1HY0 A;  1C3U A;  1W27 A;  1XL7 A;  2PTR A;  3GZH A;  3CZO A;  5HW2 A;  4BAA A;  2VSF A;  2RJS A;  1U15 A;  1TJU A; 
#chains in the Genus database with same CATH homology
 2NYN A;  2RJR A;  1I0A A;  4BAB A;  4V2R A;  1JSW A;  2OHY A;  4APA A;  1RE5 A;  4CQ5 A;  1HY1 A;  1Q5N A;  2PTQ A;  1K62 A;  4ADM A;  4C6G A;  1KQ7 A;  2PTS A;  4EFC A;  1GKJ A;  2YII A;  1VDK A;  3R6V A;  3E04 A;  4FLC A;  2PFM A;  4FFX A;  5EYT A;  4EEI A;  2E9F A;  1B8F A;  4APB A;  1GKM A;  4V2Q A;  4C5R A;  3R6Q A;  2O7E A;  1Y2M A;  1FUQ A;  5F92 A;  2O7D A;  3KDZ A;  1T6P A;  2J91 A;  1XWO A;  3UNV A;  5D6B A;  3TV2 A;  2VD6 A;  1FUO A;  1FUP A;  2QGA B;  1K7W A;  1GK2 A;  3KDY A;  3RD8 A;  2O6Y A;  4NSL A;  1TJW A;  2O78 A;  2QVE A;  3QBP A;  4C5S A;  1U16 A;  1DOF A;  3BHG A;  1T6J A;  4MX2 A;  3C8T A;  1AUW A;  1YIS A;  4NLE A;  1C3C A;  3RRP A;  3R6Y A;  1TJV A;  1DCN A;  3OCE A;  1EB4 A;  3GTD A;  2O7F A;  1J3U A;  2NYF A;  2O7B A;  5EYV A;  4HGV A;  1GK3 A;  1FUR A;  3OCF A;  4C5U A;  1YFE A;  3NZ4 A;  1YFM A;  5F91 A;  3NO9 A;  2X75 A;  1TJ7 A;  4ADL A;  2FUS A;  2HVG A;  1HY0 A;  1C3U A;  1W27 A;  2PTR A;  3GZH A;  3CZO A;  5HW2 A;  4BAA A;  2RJS A;  1U15 A;  1TJU A; 
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