5F92A

Fumarate hydratase of mycobacterium tuberculosis in complex with formate
Total Genus 179
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
179
sequence length
460
structure length
460
Chain Sequence
b'YRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQL'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Fumarate hydratase class II
publication title Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
pubmed doi rcsb
source organism Mycobacterium tuberculosis (strain cdc 1551 / oshkosh)
molecule tags Lyase
total genus 179
structure length 460
sequence length 460
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2015-12-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 5f92A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 5f92A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 5f92A02
3KDYA 4EEIA 3E04A 4NSLA 4C5SA 1T6JA 1K7WA 2O7FA 1AUWA 1B8FA 3NZ4A 2NYNA 1GK3A 4NLEA 1FUPA 2O6YA 2YIIA 3TV2A 2PTSA 4ADMA 2HVGA 1U16A 4MX2A 1GKJA 4CQ5A 1C3UA 2O7EA 1TJ7A 4C5UA 1FUQA 2PFMA 1DOFA 2RJSA 1EB4A 3OCEA 4C5RA 2PTRA 1TJUA 1I0AA 3RD8A 3C8TA 2J91A 1J3UA 3BHGA 2FUSA 2O7BA 3OCFA 1U15A 1VDKA 2E9FA 4V2RA 4FLCA 4C6GA 3QBPA 1YISA 1YFEA 5F92A 2VD6A 1JSWA 1GKMA 1XWOA 4FFXA 4HGVA 3UNVA 4APBA 3KDZA 5EYVA 1KQ7A 2X75A 1HY0A 2O78A 3R6YA 1RE5A 5HW2A 1YFMA 1FURA 1Q5NA 5EYTA 1HY1A 4APAA 2O7DA 2PTQA 1FUOA 4V2QA 3GZHA 1Y2MA 3RRPA 1TJVA 3GTDA 4ADLA 2QVEA 1C3CA 5D6BA 1DCNA 3NO9A 1GK2A 3CZOA 1W27A 3R6VA 2NYFA 4BABA 5F91A 2RJRA 2OHYA 1K62A 1T6PA 4EFCA 2QGAB 3R6QA 1TJWA 4BAAA
chains in the Genus database with same CATH superfamily
1Z4QA 4EEIA 3KDYA 3E04A 4NSLA 4C5SA 1T6JA 1K7WA 2O7FA 4IQJM 1AUWA 1B8FA 3NZ4A 2NYNA 1XL7A 1GK3A 2FELA 1Z4KA 4NLEA 1FUPA 2O6YA 2YIIA 1Q91A 5M0JA 3TV2A 2PTSA 4ADMA 2HVGA 1U16A 4MX2A 1GKJA 5M0IA 4CQ5A 1C3UA 2O7EA 1TJ7A 4C5UA 1FUQA 2PFMA 3CRW1 3U13A 1DOFA 3F4RA 3BWVA 3F4TA 2RJSA 1EB4A 1Z4PX 1IW7D 3OCEA 4C5RA 2PTRA 1TJUA 1I0AA 4L57A 3RD8A 3C8TA 3F4SA 4NFLA 2J91A 1J3UA 3BHGA 1XL8A 1MH9A 2I7DA 2FUSA 2O7BA 2JARA 3OCFA 4YIKA 1U15A 1VDKA 2E9FA 4V2RA 4FLCA 4C6GA 2FENA 3QBPA 4YIHA 1YISA 1YFEA 5F92A 1TJWA 2VD6A 1JSWA 1GKMA 1XWOA 4WNLA 4FFXA 4HGVA 3UNVA 4APBA 4E88A 3KDZA 5EYVA 2D28C 2JAUA 1KQ7A 2RCNA 2X75A 2D27A 1HY0A 2O78A 3R6YA 1RE5A 5HW2A 1Z4LA 2VL7A 2VSFA 1YFMA 4L6AA 1FURA 1Q92A 5EYTA 1HY1A 4APAA 2O7DA 4A15A 2PTQA 1FUOA 4V2QA 3CI0K 4L6CA 2JAWA 3GZHA 1Y2MA 2JAOA 1TJVA 2YV5A 3GTDA 3RRPA 4ADLA 2QVEA 1C3CA 1Z4MA 5D6BA 1DCNA 1Z4JA 3NO9A 1GK2A 3CRVA 3CZOA 4MUMA 3U19A 1W27A 3R6VA 2NYFA 4BABA 1T9HA 1Z4IA 5F91A 2RJRA 1XLYA 1XMDA 1U0LA 2OHYA 1K62A 1T6PA 4MWOA 4EFCA 1XMCA 5H8WA 2QGAB 3R6QA 1Q5NA 4BAAA
chains in the Genus database with same CATH topology
3KDYA 4EEIA 3E04A 4NSLA 4C5SA 1T6JA 1K7WA 2O7FA 1AUWA 1B8FA 3NZ4A 2NYNA 1GK3A 4NLEA 1FUPA 2O6YA 2YIIA 3TV2A 2PTSA 4ADMA 2HVGA 1U16A 4MX2A 1GKJA 4CQ5A 1C3UA 2O7EA 1TJ7A 4C5UA 1FUQA 2PFMA 1DOFA 2RJSA 1EB4A 3OCEA 4C5RA 2PTRA 1TJUA 1I0AA 3RD8A 3C8TA 2J91A 1J3UA 3BHGA 2FUSA 2O7BA 3OCFA 1U15A 1VDKA 2E9FA 4V2RA 4FLCA 4C6GA 3QBPA 1YISA 1YFEA 5F92A 2VD6A 1JSWA 1GKMA 1XWOA 4FFXA 4HGVA 3UNVA 4APBA 3KDZA 5EYVA 1KQ7A 2X75A 1HY0A 2O78A 3R6YA 1RE5A 5HW2A 1YFMA 1FURA 1Q5NA 5EYTA 1HY1A 4APAA 2O7DA 2PTQA 1FUOA 4V2QA 3GZHA 1Y2MA 3RRPA 1TJVA 3GTDA 4ADLA 2QVEA 1C3CA 5D6BA 1DCNA 3NO9A 1GK2A 3CZOA 1W27A 3R6VA 2NYFA 4BABA 5F91A 2RJRA 2OHYA 1K62A 1T6PA 4EFCA 2QGAB 3R6QA 1TJWA 4BAAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KDY A;  4EEI A;  3E04 A;  4NSL A;  4C5S A;  1T6J A;  1K7W A;  2O7F A;  1AUW A;  1B8F A;  3NZ4 A;  2NYN A;  1GK3 A;  4NLE A;  1FUP A;  2O6Y A;  2YII A;  3TV2 A;  2PTS A;  4ADM A;  2HVG A;  1U16 A;  4MX2 A;  1GKJ A;  4CQ5 A;  1C3U A;  2O7E A;  1TJ7 A;  4C5U A;  1FUQ A;  2PFM A;  1DOF A;  2RJS A;  1EB4 A;  3OCE A;  4C5R A;  2PTR A;  1TJU A;  1I0A A;  3RD8 A;  3C8T A;  2J91 A;  1J3U A;  3BHG A;  2FUS A;  2O7B A;  3OCF A;  1U15 A;  1VDK A;  2E9F A;  4V2R A;  4FLC A;  4C6G A;  3QBP A;  1YIS A;  1YFE A;  5F92 A;  2VD6 A;  1JSW A;  1GKM A;  1XWO A;  4FFX A;  4HGV A;  3UNV A;  4APB A;  3KDZ A;  5EYV A;  1KQ7 A;  2X75 A;  1HY0 A;  2O78 A;  3R6Y A;  1RE5 A;  5HW2 A;  1YFM A;  1FUR A;  1Q5N A;  5EYT A;  1HY1 A;  4APA A;  2O7D A;  2PTQ A;  1FUO A;  4V2Q A;  3GZH A;  1Y2M A;  3RRP A;  1TJV A;  3GTD A;  4ADL A;  2QVE A;  1C3C A;  5D6B A;  1DCN A;  3NO9 A;  1GK2 A;  3CZO A;  1W27 A;  3R6V A;  2NYF A;  4BAB A;  5F91 A;  2RJR A;  2OHY A;  1K62 A;  1T6P A;  4EFC A;  2QGA B;  3R6Q A;  1TJW A;  4BAA A; 
#chains in the Genus database with same CATH topology
 1Z4Q A;  4EEI A;  3KDY A;  3E04 A;  4NSL A;  4C5S A;  1T6J A;  1K7W A;  2O7F A;  4IQJ M;  1AUW A;  1B8F A;  3NZ4 A;  2NYN A;  1XL7 A;  1GK3 A;  2FEL A;  1Z4K A;  4NLE A;  1FUP A;  2O6Y A;  2YII A;  1Q91 A;  5M0J A;  3TV2 A;  2PTS A;  4ADM A;  2HVG A;  1U16 A;  4MX2 A;  1GKJ A;  5M0I A;  4CQ5 A;  1C3U A;  2O7E A;  1TJ7 A;  4C5U A;  1FUQ A;  2PFM A;  3CRW 1;  3U13 A;  1DOF A;  3F4R A;  3BWV A;  3F4T A;  2RJS A;  1EB4 A;  1Z4P X;  1IW7 D;  3OCE A;  4C5R A;  2PTR A;  1TJU A;  1I0A A;  4L57 A;  3RD8 A;  3C8T A;  3F4S A;  4NFL A;  2J91 A;  1J3U A;  3BHG A;  1XL8 A;  1MH9 A;  2I7D A;  2FUS A;  2O7B A;  2JAR A;  3OCF A;  4YIK A;  1U15 A;  1VDK A;  2E9F A;  4V2R A;  4FLC A;  4C6G A;  2FEN A;  3QBP A;  4YIH A;  1YIS A;  1YFE A;  5F92 A;  1TJW A;  2VD6 A;  1JSW A;  1GKM A;  1XWO A;  4WNL A;  4FFX A;  4HGV A;  3UNV A;  4APB A;  4E88 A;  3KDZ A;  5EYV A;  2D28 C;  2JAU A;  1KQ7 A;  2RCN A;  2X75 A;  2D27 A;  1HY0 A;  2O78 A;  3R6Y A;  1RE5 A;  5HW2 A;  1Z4L A;  2VL7 A;  2VSF A;  1YFM A;  4L6A A;  1FUR A;  1Q92 A;  5EYT A;  1HY1 A;  4APA A;  2O7D A;  4A15 A;  2PTQ A;  1FUO A;  4V2Q A;  3CI0 K;  4L6C A;  2JAW A;  3GZH A;  1Y2M A;  2JAO A;  1TJV A;  2YV5 A;  3GTD A;  3RRP A;  4ADL A;  2QVE A;  1C3C A;  1Z4M A;  5D6B A;  1DCN A;  1Z4J A;  3NO9 A;  1GK2 A;  3CRV A;  3CZO A;  4MUM A;  3U19 A;  1W27 A;  3R6V A;  2NYF A;  4BAB A;  1T9H A;  1Z4I A;  5F91 A;  2RJR A;  1XLY A;  1XMD A;  1U0L A;  2OHY A;  1K62 A;  1T6P A;  4MWO A;  4EFC A;  1XMC A;  5H8W A;  2QGA B;  3R6Q A;  1Q5N A;  4BAA A; 
#chains in the Genus database with same CATH homology
 3KDY A;  4EEI A;  3E04 A;  4NSL A;  4C5S A;  1T6J A;  1K7W A;  2O7F A;  1AUW A;  1B8F A;  3NZ4 A;  2NYN A;  1GK3 A;  4NLE A;  1FUP A;  2O6Y A;  2YII A;  3TV2 A;  2PTS A;  4ADM A;  2HVG A;  1U16 A;  4MX2 A;  1GKJ A;  4CQ5 A;  1C3U A;  2O7E A;  1TJ7 A;  4C5U A;  1FUQ A;  2PFM A;  1DOF A;  2RJS A;  1EB4 A;  3OCE A;  4C5R A;  2PTR A;  1TJU A;  1I0A A;  3RD8 A;  3C8T A;  2J91 A;  1J3U A;  3BHG A;  2FUS A;  2O7B A;  3OCF A;  1U15 A;  1VDK A;  2E9F A;  4V2R A;  4FLC A;  4C6G A;  3QBP A;  1YIS A;  1YFE A;  5F92 A;  2VD6 A;  1JSW A;  1GKM A;  1XWO A;  4FFX A;  4HGV A;  3UNV A;  4APB A;  3KDZ A;  5EYV A;  1KQ7 A;  2X75 A;  1HY0 A;  2O78 A;  3R6Y A;  1RE5 A;  5HW2 A;  1YFM A;  1FUR A;  1Q5N A;  5EYT A;  1HY1 A;  4APA A;  2O7D A;  2PTQ A;  1FUO A;  4V2Q A;  3GZH A;  1Y2M A;  3RRP A;  1TJV A;  3GTD A;  4ADL A;  2QVE A;  1C3C A;  5D6B A;  1DCN A;  3NO9 A;  1GK2 A;  3CZO A;  1W27 A;  3R6V A;  2NYF A;  4BAB A;  5F91 A;  2RJR A;  2OHY A;  1K62 A;  1T6P A;  4EFC A;  2QGA B;  3R6Q A;  1TJW A;  4BAA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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