5F92A

Fumarate hydratase of mycobacterium tuberculosis in complex with formate
Total Genus 179
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
179
sequence length
460
structure length
460
Chain Sequence
YRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lyase
molecule keywords Fumarate hydratase class II
publication title Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
pubmed doi rcsb
source organism Mycobacterium tuberculosis (strain cdc 1551 / oshkosh)
total genus 179
structure length 460
sequence length 460
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2015-12-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 5f92A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 5f92A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 5f92A02
1I0AA 1GKJA 4V2QA 2RJSA 4C5RA 5HW2A 3R6YA 5EYTA 4ADLA 3GZHA 2HVGA 3E04A 4APAA 1YFMA 1TJ7A 4NSLA 2PTQA 1B8FA 2O7DA 1J3UA 2O6YA 2J91A 3RRPA 3C8TA 2YIIA 1FUPA 3CZOA 4C5SA 4BABA 1DCNA 1HY0A 1GKMA 1KQ7A 5D6BA 1K62A 1XWOA 4MX2A 4BAAA 2OHYA 1FUQA 1DOFA 4NLEA 1TJVA 4EFCA 2PTRA 1HY1A 1RE5A 3UNVA 2O7FA 3OCEA 4FLCA 2O7BA 1YISA 2O78A 3BHGA 1K7WA 1FURA 2PTSA 2VD6A 1C3UA 2PFMA 3QBPA 4C6GA 2O7EA 1YFEA 3R6VA 1GK2A 4EEIA 2QGAB 4C5UA 4HGVA 5F92A 3KDZA 3R6QA 1T6JA 2X75A 1JSWA 1U16A 5EYVA 1T6PA 3OCFA 1Y2MA 4CQ5A 1TJUA 1AUWA 3NZ4A 1EB4A 2QVEA 3KDYA 2NYNA 3RD8A 4ADMA 1W27A 1VDKA 2RJRA 4APBA 1GK3A 3NO9A 3TV2A 2E9FA 2FUSA 1U15A 2NYFA 3GTDA 1TJWA 1Q5NA 4FFXA 1C3CA 1FUOA 5F91A 4V2RA
chains in the Genus database with same CATH superfamily
1Q92A 1I0AA 3CRW1 1GKJA 2JAWA 4V2QA 2RJSA 4YIKA 4C5RA 5HW2A 3R6YA 5EYTA 2FENA 4ADLA 2D27A 2JAUA 3GZHA 2HVGA 3E04A 4APAA 1YFMA 1TJ7A 1MH9A 4NSLA 2FELA 2PTQA 1B8FA 2O7DA 1J3UA 2O6YA 2J91A 3RRPA 1XMCA 1Z4KA 3C8TA 1XMDA 4MUMA 4WNLA 2YIIA 1FUPA 3CZOA 4C5SA 1IW7D 4BABA 1DCNA 4IQJM 1HY0A 1GKMA 1KQ7A 5D6BA 3F4SA 1K62A 3CRVA 1XWOA 4MX2A 4BAAA 2OHYA 1FUQA 4MWOA 2JARA 4L57A 1DOFA 2D28C 2YV5A 5M0IA 4NLEA 5H8WA 1U0LA 3F4RA 1TJVA 4EFCA 2PTRA 3CI0K 1HY1A 1RE5A 2JAOA 3BWVA 3UNVA 4NFLA 2O7FA 3OCEA 2RCNA 1Z4QA 3U13A 4FLCA 2O7BA 1YISA 2O78A 4YIHA 3BHGA 1K7WA 1Z4PX 3U19A 1FURA 2I7DA 2VSFA 2PTSA 2VD6A 1C3UA 2PFMA 2VL7A 3QBPA 4C6GA 2O7EA 1YFEA 1T9HA 1Z4IA 3R6VA 1GK2A 4EEIA 2QGAB 4C5UA 1Z4LA 4HGVA 5F92A 3KDZA 3R6QA 1T6JA 1XL7A 1Q91A 2X75A 1JSWA 1U16A 5EYVA 1XLYA 1T6PA 3OCFA 1Y2MA 1Z4MA 4CQ5A 1TJUA 1AUWA 3NZ4A 1Z4JA 1EB4A 2QVEA 3KDYA 2NYNA 3RD8A 4ADMA 1W27A 1VDKA 3F4TA 2RJRA 5M0JA 4APBA 1GK3A 3NO9A 3TV2A 4E88A 2E9FA 2FUSA 1U15A 2NYFA 4A15A 3GTDA 1TJWA 1Q5NA 4L6CA 4FFXA 1C3CA 1FUOA 5F91A 4V2RA 4L6AA 1XL8A
chains in the Genus database with same CATH topology
1I0AA 1GKJA 4V2QA 2RJSA 4C5RA 5HW2A 3R6YA 5EYTA 4ADLA 3GZHA 2HVGA 3E04A 4APAA 1YFMA 1TJ7A 4NSLA 2PTQA 1B8FA 2O7DA 1J3UA 2O6YA 2J91A 3RRPA 3C8TA 2YIIA 1FUPA 3CZOA 4C5SA 4BABA 1DCNA 1HY0A 1GKMA 1KQ7A 5D6BA 1K62A 1XWOA 4MX2A 4BAAA 2OHYA 1FUQA 1DOFA 4NLEA 1TJVA 4EFCA 2PTRA 1HY1A 1RE5A 3UNVA 2O7FA 3OCEA 4FLCA 2O7BA 1YISA 2O78A 3BHGA 1K7WA 1FURA 2PTSA 2VD6A 1C3UA 2PFMA 3QBPA 4C6GA 2O7EA 1YFEA 3R6VA 1GK2A 4EEIA 2QGAB 4C5UA 4HGVA 5F92A 3KDZA 3R6QA 1T6JA 2X75A 1JSWA 1U16A 5EYVA 1T6PA 3OCFA 1Y2MA 4CQ5A 1TJUA 1AUWA 3NZ4A 1EB4A 2QVEA 3KDYA 2NYNA 3RD8A 4ADMA 1W27A 1VDKA 2RJRA 4APBA 1GK3A 3NO9A 3TV2A 2E9FA 2FUSA 1U15A 2NYFA 3GTDA 1TJWA 1Q5NA 4FFXA 1C3CA 1FUOA 5F91A 4V2RA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I0A A;  1GKJ A;  4V2Q A;  2RJS A;  4C5R A;  5HW2 A;  3R6Y A;  5EYT A;  4ADL A;  3GZH A;  2HVG A;  3E04 A;  4APA A;  1YFM A;  1TJ7 A;  4NSL A;  2PTQ A;  1B8F A;  2O7D A;  1J3U A;  2O6Y A;  2J91 A;  3RRP A;  3C8T A;  2YII A;  1FUP A;  3CZO A;  4C5S A;  4BAB A;  1DCN A;  1HY0 A;  1GKM A;  1KQ7 A;  5D6B A;  1K62 A;  1XWO A;  4MX2 A;  4BAA A;  2OHY A;  1FUQ A;  1DOF A;  4NLE A;  1TJV A;  4EFC A;  2PTR A;  1HY1 A;  1RE5 A;  3UNV A;  2O7F A;  3OCE A;  4FLC A;  2O7B A;  1YIS A;  2O78 A;  3BHG A;  1K7W A;  1FUR A;  2PTS A;  2VD6 A;  1C3U A;  2PFM A;  3QBP A;  4C6G A;  2O7E A;  1YFE A;  3R6V A;  1GK2 A;  4EEI A;  2QGA B;  4C5U A;  4HGV A;  5F92 A;  3KDZ A;  3R6Q A;  1T6J A;  2X75 A;  1JSW A;  1U16 A;  5EYV A;  1T6P A;  3OCF A;  1Y2M A;  4CQ5 A;  1TJU A;  1AUW A;  3NZ4 A;  1EB4 A;  2QVE A;  3KDY A;  2NYN A;  3RD8 A;  4ADM A;  1W27 A;  1VDK A;  2RJR A;  4APB A;  1GK3 A;  3NO9 A;  3TV2 A;  2E9F A;  2FUS A;  1U15 A;  2NYF A;  3GTD A;  1TJW A;  1Q5N A;  4FFX A;  1C3C A;  1FUO A;  5F91 A;  4V2R A; 
#chains in the Genus database with same CATH topology
 1Q92 A;  1I0A A;  3CRW 1;  1GKJ A;  2JAW A;  4V2Q A;  2RJS A;  4YIK A;  4C5R A;  5HW2 A;  3R6Y A;  5EYT A;  2FEN A;  4ADL A;  2D27 A;  2JAU A;  3GZH A;  2HVG A;  3E04 A;  4APA A;  1YFM A;  1TJ7 A;  1MH9 A;  4NSL A;  2FEL A;  2PTQ A;  1B8F A;  2O7D A;  1J3U A;  2O6Y A;  2J91 A;  3RRP A;  1XMC A;  1Z4K A;  3C8T A;  1XMD A;  4MUM A;  4WNL A;  2YII A;  1FUP A;  3CZO A;  4C5S A;  1IW7 D;  4BAB A;  1DCN A;  4IQJ M;  1HY0 A;  1GKM A;  1KQ7 A;  5D6B A;  3F4S A;  1K62 A;  3CRV A;  1XWO A;  4MX2 A;  4BAA A;  2OHY A;  1FUQ A;  4MWO A;  2JAR A;  4L57 A;  1DOF A;  2D28 C;  2YV5 A;  5M0I A;  4NLE A;  5H8W A;  1U0L A;  3F4R A;  1TJV A;  4EFC A;  2PTR A;  3CI0 K;  1HY1 A;  1RE5 A;  2JAO A;  3BWV A;  3UNV A;  4NFL A;  2O7F A;  3OCE A;  2RCN A;  1Z4Q A;  3U13 A;  4FLC A;  2O7B A;  1YIS A;  2O78 A;  4YIH A;  3BHG A;  1K7W A;  1Z4P X;  3U19 A;  1FUR A;  2I7D A;  2VSF A;  2PTS A;  2VD6 A;  1C3U A;  2PFM A;  2VL7 A;  3QBP A;  4C6G A;  2O7E A;  1YFE A;  1T9H A;  1Z4I A;  3R6V A;  1GK2 A;  4EEI A;  2QGA B;  4C5U A;  1Z4L A;  4HGV A;  5F92 A;  3KDZ A;  3R6Q A;  1T6J A;  1XL7 A;  1Q91 A;  2X75 A;  1JSW A;  1U16 A;  5EYV A;  1XLY A;  1T6P A;  3OCF A;  1Y2M A;  1Z4M A;  4CQ5 A;  1TJU A;  1AUW A;  3NZ4 A;  1Z4J A;  1EB4 A;  2QVE A;  3KDY A;  2NYN A;  3RD8 A;  4ADM A;  1W27 A;  1VDK A;  3F4T A;  2RJR A;  5M0J A;  4APB A;  1GK3 A;  3NO9 A;  3TV2 A;  4E88 A;  2E9F A;  2FUS A;  1U15 A;  2NYF A;  4A15 A;  3GTD A;  1TJW A;  1Q5N A;  4L6C A;  4FFX A;  1C3C A;  1FUO A;  5F91 A;  4V2R A;  4L6A A;  1XL8 A; 
#chains in the Genus database with same CATH homology
 1I0A A;  1GKJ A;  4V2Q A;  2RJS A;  4C5R A;  5HW2 A;  3R6Y A;  5EYT A;  4ADL A;  3GZH A;  2HVG A;  3E04 A;  4APA A;  1YFM A;  1TJ7 A;  4NSL A;  2PTQ A;  1B8F A;  2O7D A;  1J3U A;  2O6Y A;  2J91 A;  3RRP A;  3C8T A;  2YII A;  1FUP A;  3CZO A;  4C5S A;  4BAB A;  1DCN A;  1HY0 A;  1GKM A;  1KQ7 A;  5D6B A;  1K62 A;  1XWO A;  4MX2 A;  4BAA A;  2OHY A;  1FUQ A;  1DOF A;  4NLE A;  1TJV A;  4EFC A;  2PTR A;  1HY1 A;  1RE5 A;  3UNV A;  2O7F A;  3OCE A;  4FLC A;  2O7B A;  1YIS A;  2O78 A;  3BHG A;  1K7W A;  1FUR A;  2PTS A;  2VD6 A;  1C3U A;  2PFM A;  3QBP A;  4C6G A;  2O7E A;  1YFE A;  3R6V A;  1GK2 A;  4EEI A;  2QGA B;  4C5U A;  4HGV A;  5F92 A;  3KDZ A;  3R6Q A;  1T6J A;  2X75 A;  1JSW A;  1U16 A;  5EYV A;  1T6P A;  3OCF A;  1Y2M A;  4CQ5 A;  1TJU A;  1AUW A;  3NZ4 A;  1EB4 A;  2QVE A;  3KDY A;  2NYN A;  3RD8 A;  4ADM A;  1W27 A;  1VDK A;  2RJR A;  4APB A;  1GK3 A;  3NO9 A;  3TV2 A;  2E9F A;  2FUS A;  1U15 A;  2NYF A;  3GTD A;  1TJW A;  1Q5N A;  4FFX A;  1C3C A;  1FUO A;  5F91 A;  4V2R A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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