5F92A

Fumarate hydratase of mycobacterium tuberculosis in complex with formate
Total Genus 179
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
179
sequence length
460
structure length
460
Chain Sequence
YRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Fumarate hydratase class II
publication title Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
pubmed doi rcsb
source organism Mycobacterium tuberculosis (strain cdc 1551 / oshkosh)
molecule tags Lyase
total genus 179
structure length 460
sequence length 460
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2015-12-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 5f92A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 5f92A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 5f92A02
5F91A 1TJ7A 2O7BA 4FFXA 1B8FA 3GTDA 4ADMA 1HY1A 3C8TA 3NZ4A 4APBA 2YIIA 2X75A 4C5RA 1TJUA 4HGVA 1JSWA 3GZHA 5F92A 4NSLA 1EB4A 3NO9A 1GKMA 4ADLA 1TJVA 1K62A 5EYTA 1J3UA 1FUPA 1GK3A 3R6YA 4C6GA 1Y2MA 4C5UA 1XWOA 1KQ7A 2O7FA 1T6PA 2O6YA 3OCFA 4V2RA 1FURA 1Q5NA 2QVEA 2OHYA 2PTQA 2O7DA 1FUQA 2O78A 4V2QA 1DOFA 1C3CA 1TJWA 2FUSA 2VD6A 2PTSA 1GK2A 4EEIA 3KDZA 3CZOA 2RJRA 1FUOA 3QBPA 1YFEA 2PTRA 1RE5A 1YISA 1K7WA 3E04A 1AUWA 4EFCA 4NLEA 2J91A 5EYVA 3OCEA 3R6QA 4BABA 4APAA 5D6BA 1VDKA 2HVGA 2QGAB 3R6VA 3TV2A 1DCNA 2PFMA 3RRPA 1U15A 3RD8A 1T6JA 3KDYA 1HY0A 5HW2A 3BHGA 2O7EA 2E9FA 1GKJA 1W27A 2NYNA 2RJSA 4C5SA 4CQ5A 1I0AA 2NYFA 1YFMA 4BAAA 3UNVA 4MX2A 1U16A 1C3UA 4FLCA
chains in the Genus database with same CATH superfamily
1XL8A 5M0IA 5F91A 1TJ7A 2O7BA 4FFXA 1Q92A 1B8FA 3F4TA 3GTDA 5M0JA 4ADMA 1HY1A 3C8TA 3NZ4A 4MUMA 4APBA 2YIIA 2X75A 1Z4LA 4C5RA 1TJUA 4HGVA 1JSWA 3CI0K 1Z4PX 1XMDA 3GZHA 1U0LA 2RCNA 1Z4JA 5F92A 4NSLA 1EB4A 3NO9A 1GKMA 1Z4KA 4YIKA 4ADLA 1TJVA 1K62A 3BWVA 5EYTA 1J3UA 1FUPA 1GK3A 3R6YA 4C6GA 1Y2MA 4C5UA 1XWOA 1KQ7A 2O7FA 1T6PA 2O6YA 3OCFA 4V2RA 4L57A 1FURA 1Q5NA 2QVEA 2OHYA 2PTQA 1XLYA 2O7DA 1FUQA 2O78A 4V2QA 1DOFA 1C3CA 1TJWA 2FUSA 2VD6A 5H8WA 2PTSA 1GK2A 1Z4QA 4EEIA 3KDZA 3CZOA 2RJRA 1FUOA 2D27A 3QBPA 1YFEA 2PTRA 1RE5A 4IQJM 1YISA 1K7WA 1MH9A 3E04A 1Q91A 1AUWA 1Z4MA 4EFCA 4L6AA 4NLEA 2J91A 5EYVA 4YIHA 1XMCA 3OCEA 4NFLA 2FELA 3R6QA 4BABA 3F4SA 4L6CA 4APAA 2YV5A 1T9HA 5D6BA 3CRVA 1VDKA 2HVGA 2I7DA 2JAWA 2QGAB 3F4RA 3R6VA 3TV2A 1DCNA 2PFMA 2VL7A 4MWOA 3RRPA 1U15A 1Z4IA 2JARA 3RD8A 2VSFA 1T6JA 3CRW1 3KDYA 4E88A 1HY0A 5HW2A 3BHGA 2O7EA 2E9FA 1GKJA 1W27A 2NYNA 2FENA 2D28C 4WNLA 3U19A 2RJSA 1IW7D 1XL7A 4C5SA 4CQ5A 1I0AA 2JAUA 2NYFA 1YFMA 4BAAA 3UNVA 4MX2A 2JAOA 4A15A 1U16A 3U13A 1C3UA 4FLCA
chains in the Genus database with same CATH topology
5F91A 1TJ7A 2O7BA 4FFXA 1B8FA 3GTDA 4ADMA 1HY1A 3C8TA 3NZ4A 4APBA 2YIIA 2X75A 4C5RA 1TJUA 4HGVA 1JSWA 3GZHA 5F92A 4NSLA 1EB4A 3NO9A 1GKMA 4ADLA 1TJVA 1K62A 5EYTA 1J3UA 1FUPA 1GK3A 3R6YA 4C6GA 1Y2MA 4C5UA 1XWOA 1KQ7A 2O7FA 1T6PA 2O6YA 3OCFA 4V2RA 1FURA 1Q5NA 2QVEA 2OHYA 2PTQA 2O7DA 1FUQA 2O78A 4V2QA 1DOFA 1C3CA 1TJWA 2FUSA 2VD6A 2PTSA 1GK2A 4EEIA 3KDZA 3CZOA 2RJRA 1FUOA 3QBPA 1YFEA 2PTRA 1RE5A 1YISA 1K7WA 3E04A 1AUWA 4EFCA 4NLEA 2J91A 5EYVA 3OCEA 3R6QA 4BABA 4APAA 5D6BA 1VDKA 2HVGA 2QGAB 3R6VA 3TV2A 1DCNA 2PFMA 3RRPA 1U15A 3RD8A 1T6JA 3KDYA 1HY0A 5HW2A 3BHGA 2O7EA 2E9FA 1GKJA 1W27A 2NYNA 2RJSA 4C5SA 4CQ5A 1I0AA 2NYFA 1YFMA 4BAAA 3UNVA 4MX2A 1U16A 1C3UA 4FLCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5F91 A;  1TJ7 A;  2O7B A;  4FFX A;  1B8F A;  3GTD A;  4ADM A;  1HY1 A;  3C8T A;  3NZ4 A;  4APB A;  2YII A;  2X75 A;  4C5R A;  1TJU A;  4HGV A;  1JSW A;  3GZH A;  5F92 A;  4NSL A;  1EB4 A;  3NO9 A;  1GKM A;  4ADL A;  1TJV A;  1K62 A;  5EYT A;  1J3U A;  1FUP A;  1GK3 A;  3R6Y A;  4C6G A;  1Y2M A;  4C5U A;  1XWO A;  1KQ7 A;  2O7F A;  1T6P A;  2O6Y A;  3OCF A;  4V2R A;  1FUR A;  1Q5N A;  2QVE A;  2OHY A;  2PTQ A;  2O7D A;  1FUQ A;  2O78 A;  4V2Q A;  1DOF A;  1C3C A;  1TJW A;  2FUS A;  2VD6 A;  2PTS A;  1GK2 A;  4EEI A;  3KDZ A;  3CZO A;  2RJR A;  1FUO A;  3QBP A;  1YFE A;  2PTR A;  1RE5 A;  1YIS A;  1K7W A;  3E04 A;  1AUW A;  4EFC A;  4NLE A;  2J91 A;  5EYV A;  3OCE A;  3R6Q A;  4BAB A;  4APA A;  5D6B A;  1VDK A;  2HVG A;  2QGA B;  3R6V A;  3TV2 A;  1DCN A;  2PFM A;  3RRP A;  1U15 A;  3RD8 A;  1T6J A;  3KDY A;  1HY0 A;  5HW2 A;  3BHG A;  2O7E A;  2E9F A;  1GKJ A;  1W27 A;  2NYN A;  2RJS A;  4C5S A;  4CQ5 A;  1I0A A;  2NYF A;  1YFM A;  4BAA A;  3UNV A;  4MX2 A;  1U16 A;  1C3U A;  4FLC A; 
#chains in the Genus database with same CATH topology
 1XL8 A;  5M0I A;  5F91 A;  1TJ7 A;  2O7B A;  4FFX A;  1Q92 A;  1B8F A;  3F4T A;  3GTD A;  5M0J A;  4ADM A;  1HY1 A;  3C8T A;  3NZ4 A;  4MUM A;  4APB A;  2YII A;  2X75 A;  1Z4L A;  4C5R A;  1TJU A;  4HGV A;  1JSW A;  3CI0 K;  1Z4P X;  1XMD A;  3GZH A;  1U0L A;  2RCN A;  1Z4J A;  5F92 A;  4NSL A;  1EB4 A;  3NO9 A;  1GKM A;  1Z4K A;  4YIK A;  4ADL A;  1TJV A;  1K62 A;  3BWV A;  5EYT A;  1J3U A;  1FUP A;  1GK3 A;  3R6Y A;  4C6G A;  1Y2M A;  4C5U A;  1XWO A;  1KQ7 A;  2O7F A;  1T6P A;  2O6Y A;  3OCF A;  4V2R A;  4L57 A;  1FUR A;  1Q5N A;  2QVE A;  2OHY A;  2PTQ A;  1XLY A;  2O7D A;  1FUQ A;  2O78 A;  4V2Q A;  1DOF A;  1C3C A;  1TJW A;  2FUS A;  2VD6 A;  5H8W A;  2PTS A;  1GK2 A;  1Z4Q A;  4EEI A;  3KDZ A;  3CZO A;  2RJR A;  1FUO A;  2D27 A;  3QBP A;  1YFE A;  2PTR A;  1RE5 A;  4IQJ M;  1YIS A;  1K7W A;  1MH9 A;  3E04 A;  1Q91 A;  1AUW A;  1Z4M A;  4EFC A;  4L6A A;  4NLE A;  2J91 A;  5EYV A;  4YIH A;  1XMC A;  3OCE A;  4NFL A;  2FEL A;  3R6Q A;  4BAB A;  3F4S A;  4L6C A;  4APA A;  2YV5 A;  1T9H A;  5D6B A;  3CRV A;  1VDK A;  2HVG A;  2I7D A;  2JAW A;  2QGA B;  3F4R A;  3R6V A;  3TV2 A;  1DCN A;  2PFM A;  2VL7 A;  4MWO A;  3RRP A;  1U15 A;  1Z4I A;  2JAR A;  3RD8 A;  2VSF A;  1T6J A;  3CRW 1;  3KDY A;  4E88 A;  1HY0 A;  5HW2 A;  3BHG A;  2O7E A;  2E9F A;  1GKJ A;  1W27 A;  2NYN A;  2FEN A;  2D28 C;  4WNL A;  3U19 A;  2RJS A;  1IW7 D;  1XL7 A;  4C5S A;  4CQ5 A;  1I0A A;  2JAU A;  2NYF A;  1YFM A;  4BAA A;  3UNV A;  4MX2 A;  2JAO A;  4A15 A;  1U16 A;  3U13 A;  1C3U A;  4FLC A; 
#chains in the Genus database with same CATH homology
 5F91 A;  1TJ7 A;  2O7B A;  4FFX A;  1B8F A;  3GTD A;  4ADM A;  1HY1 A;  3C8T A;  3NZ4 A;  4APB A;  2YII A;  2X75 A;  4C5R A;  1TJU A;  4HGV A;  1JSW A;  3GZH A;  5F92 A;  4NSL A;  1EB4 A;  3NO9 A;  1GKM A;  4ADL A;  1TJV A;  1K62 A;  5EYT A;  1J3U A;  1FUP A;  1GK3 A;  3R6Y A;  4C6G A;  1Y2M A;  4C5U A;  1XWO A;  1KQ7 A;  2O7F A;  1T6P A;  2O6Y A;  3OCF A;  4V2R A;  1FUR A;  1Q5N A;  2QVE A;  2OHY A;  2PTQ A;  2O7D A;  1FUQ A;  2O78 A;  4V2Q A;  1DOF A;  1C3C A;  1TJW A;  2FUS A;  2VD6 A;  2PTS A;  1GK2 A;  4EEI A;  3KDZ A;  3CZO A;  2RJR A;  1FUO A;  3QBP A;  1YFE A;  2PTR A;  1RE5 A;  1YIS A;  1K7W A;  3E04 A;  1AUW A;  4EFC A;  4NLE A;  2J91 A;  5EYV A;  3OCE A;  3R6Q A;  4BAB A;  4APA A;  5D6B A;  1VDK A;  2HVG A;  2QGA B;  3R6V A;  3TV2 A;  1DCN A;  2PFM A;  3RRP A;  1U15 A;  3RD8 A;  1T6J A;  3KDY A;  1HY0 A;  5HW2 A;  3BHG A;  2O7E A;  2E9F A;  1GKJ A;  1W27 A;  2NYN A;  2RJS A;  4C5S A;  4CQ5 A;  1I0A A;  2NYF A;  1YFM A;  4BAA A;  3UNV A;  4MX2 A;  1U16 A;  1C3U A;  4FLC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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