5F92A

Fumarate hydratase of mycobacterium tuberculosis in complex with formate
Total Genus 179
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
179
sequence length
460
structure length
460
Chain Sequence
YRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Lyase
molecule keywords Fumarate hydratase class II
publication title Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
pubmed doi rcsb
source organism Mycobacterium tuberculosis (strain cdc 1551 / oshkosh)
total genus 179
structure length 460
sequence length 460
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2015-12-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 5f92A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 5f92A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 5f92A02
1JSWA 1U15A 1Q5NA 1GKMA 2NYNA 4HGVA 1FUPA 3KDYA 2FUSA 1W27A 1B8FA 1KQ7A 4EEIA 2PTSA 2J91A 1C3CA 4C5RA 1YFMA 2O6YA 1DCNA 2RJSA 1Y2MA 5F92A 2VD6A 5EYVA 1K62A 3UNVA 3GZHA 4CQ5A 3OCFA 1XWOA 1HY0A 4NSLA 2O7BA 2PTRA 3QBPA 1FUOA 4ADMA 2O7DA 4C5UA 2X75A 2QVEA 1T6JA 3BHGA 1YFEA 1TJVA 4MX2A 4V2RA 4APAA 5EYTA 4EFCA 4FFXA 2HVGA 4ADLA 5HW2A 1DOFA 2QGAB 4BAAA 1K7WA 5F91A 4FLCA 2O7EA 1I0AA 3GTDA 1FUQA 3E04A 2OHYA 5D6BA 3CZOA 1TJ7A 4C5SA 1J3UA 1TJUA 3R6YA 4APBA 1GKJA 4BABA 1EB4A 3RD8A 2PTQA 1T6PA 3RRPA 1RE5A 3C8TA 2RJRA 2YIIA 2O7FA 1AUWA 4V2QA 1U16A 2O78A 1VDKA 3KDZA 3OCEA 3TV2A 1GK2A 4C6GA 4NLEA 1C3UA 1YISA 3NZ4A 1TJWA 3R6QA 3R6VA 1GK3A 3NO9A 2NYFA 1HY1A 2E9FA 2PFMA 1FURA
chains in the Genus database with same CATH superfamily
1JSWA 1U15A 1Q5NA 1GKMA 2NYNA 4HGVA 1FUPA 3KDYA 2FUSA 1Z4MA 1W27A 1B8FA 1KQ7A 4EEIA 1Q91A 2PTSA 5M0JA 2FELA 2J91A 1C3CA 4C5RA 1YFMA 5H8WA 2O6YA 1DCNA 4IQJM 2FENA 2RJSA 1Y2MA 1XMCA 1T9HA 5F92A 1XL7A 2VD6A 5EYVA 1K62A 2I7DA 3UNVA 3GZHA 4CQ5A 3OCFA 1XWOA 1HY0A 2RCNA 2JAOA 4NSLA 2O7BA 2PTRA 3U13A 3QBPA 1FUOA 4MUMA 4ADMA 2O7DA 2YV5A 2X75A 4C5UA 2QVEA 1XMDA 1T6JA 3BHGA 1Z4PX 1YFEA 2D28C 1TJVA 4MX2A 4NFLA 3U19A 4V2RA 4APAA 3F4SA 5EYTA 4EFCA 3CRVA 4L57A 4FFXA 4WNLA 1U0LA 2HVGA 4ADLA 4YIHA 5HW2A 4A15A 1DOFA 4MWOA 2QGAB 4BAAA 1K7WA 3F4RA 5F91A 2JARA 3CI0K 4FLCA 1XL8A 4E88A 2O7EA 1XLYA 3F4TA 1Z4IA 1I0AA 2VSFA 3GTDA 1FUQA 3E04A 2OHYA 2VL7A 5D6BA 3CZOA 1TJ7A 4C5SA 1J3UA 2JAWA 1TJUA 3R6YA 4APBA 1GKJA 4BABA 1EB4A 4L6AA 3RD8A 2PTQA 3BWVA 1T6PA 4L6CA 3RRPA 1RE5A 2D27A 1Z4KA 3C8TA 2RJRA 2YIIA 2O7FA 1AUWA 1Q92A 4V2QA 1Z4LA 1U16A 2O78A 1VDKA 4YIKA 3KDZA 3OCEA 3TV2A 1GK2A 4C6GA 4NLEA 1C3UA 1YISA 3NZ4A 1TJWA 1Z4JA 3R6QA 3R6VA 1IW7D 1MH9A 1GK3A 5M0IA 2JAUA 3NO9A 2NYFA 1HY1A 3CRW1 1Z4QA 2E9FA 2PFMA 1FURA
chains in the Genus database with same CATH topology
1JSWA 1U15A 1Q5NA 1GKMA 2NYNA 4HGVA 1FUPA 3KDYA 2FUSA 1W27A 1B8FA 1KQ7A 4EEIA 2PTSA 2J91A 1C3CA 4C5RA 1YFMA 2O6YA 1DCNA 2RJSA 1Y2MA 5F92A 2VD6A 5EYVA 1K62A 3UNVA 3GZHA 4CQ5A 3OCFA 1XWOA 1HY0A 4NSLA 2O7BA 2PTRA 3QBPA 1FUOA 4ADMA 2O7DA 4C5UA 2X75A 2QVEA 1T6JA 3BHGA 1YFEA 1TJVA 4MX2A 4V2RA 4APAA 5EYTA 4EFCA 4FFXA 2HVGA 4ADLA 5HW2A 1DOFA 2QGAB 4BAAA 1K7WA 5F91A 4FLCA 2O7EA 1I0AA 3GTDA 1FUQA 3E04A 2OHYA 5D6BA 3CZOA 1TJ7A 4C5SA 1J3UA 1TJUA 3R6YA 4APBA 1GKJA 4BABA 1EB4A 3RD8A 2PTQA 1T6PA 3RRPA 1RE5A 3C8TA 2RJRA 2YIIA 2O7FA 1AUWA 4V2QA 1U16A 2O78A 1VDKA 3KDZA 3OCEA 3TV2A 1GK2A 4C6GA 4NLEA 1C3UA 1YISA 3NZ4A 1TJWA 3R6QA 3R6VA 1GK3A 3NO9A 2NYFA 1HY1A 2E9FA 2PFMA 1FURA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1JSW A;  1U15 A;  1Q5N A;  1GKM A;  2NYN A;  4HGV A;  1FUP A;  3KDY A;  2FUS A;  1W27 A;  1B8F A;  1KQ7 A;  4EEI A;  2PTS A;  2J91 A;  1C3C A;  4C5R A;  1YFM A;  2O6Y A;  1DCN A;  2RJS A;  1Y2M A;  5F92 A;  2VD6 A;  5EYV A;  1K62 A;  3UNV A;  3GZH A;  4CQ5 A;  3OCF A;  1XWO A;  1HY0 A;  4NSL A;  2O7B A;  2PTR A;  3QBP A;  1FUO A;  4ADM A;  2O7D A;  4C5U A;  2X75 A;  2QVE A;  1T6J A;  3BHG A;  1YFE A;  1TJV A;  4MX2 A;  4V2R A;  4APA A;  5EYT A;  4EFC A;  4FFX A;  2HVG A;  4ADL A;  5HW2 A;  1DOF A;  2QGA B;  4BAA A;  1K7W A;  5F91 A;  4FLC A;  2O7E A;  1I0A A;  3GTD A;  1FUQ A;  3E04 A;  2OHY A;  5D6B A;  3CZO A;  1TJ7 A;  4C5S A;  1J3U A;  1TJU A;  3R6Y A;  4APB A;  1GKJ A;  4BAB A;  1EB4 A;  3RD8 A;  2PTQ A;  1T6P A;  3RRP A;  1RE5 A;  3C8T A;  2RJR A;  2YII A;  2O7F A;  1AUW A;  4V2Q A;  1U16 A;  2O78 A;  1VDK A;  3KDZ A;  3OCE A;  3TV2 A;  1GK2 A;  4C6G A;  4NLE A;  1C3U A;  1YIS A;  3NZ4 A;  1TJW A;  3R6Q A;  3R6V A;  1GK3 A;  3NO9 A;  2NYF A;  1HY1 A;  2E9F A;  2PFM A;  1FUR A; 
#chains in the Genus database with same CATH topology
 1JSW A;  1U15 A;  1Q5N A;  1GKM A;  2NYN A;  4HGV A;  1FUP A;  3KDY A;  2FUS A;  1Z4M A;  1W27 A;  1B8F A;  1KQ7 A;  4EEI A;  1Q91 A;  2PTS A;  5M0J A;  2FEL A;  2J91 A;  1C3C A;  4C5R A;  1YFM A;  5H8W A;  2O6Y A;  1DCN A;  4IQJ M;  2FEN A;  2RJS A;  1Y2M A;  1XMC A;  1T9H A;  5F92 A;  1XL7 A;  2VD6 A;  5EYV A;  1K62 A;  2I7D A;  3UNV A;  3GZH A;  4CQ5 A;  3OCF A;  1XWO A;  1HY0 A;  2RCN A;  2JAO A;  4NSL A;  2O7B A;  2PTR A;  3U13 A;  3QBP A;  1FUO A;  4MUM A;  4ADM A;  2O7D A;  2YV5 A;  2X75 A;  4C5U A;  2QVE A;  1XMD A;  1T6J A;  3BHG A;  1Z4P X;  1YFE A;  2D28 C;  1TJV A;  4MX2 A;  4NFL A;  3U19 A;  4V2R A;  4APA A;  3F4S A;  5EYT A;  4EFC A;  3CRV A;  4L57 A;  4FFX A;  4WNL A;  1U0L A;  2HVG A;  4ADL A;  4YIH A;  5HW2 A;  4A15 A;  1DOF A;  4MWO A;  2QGA B;  4BAA A;  1K7W A;  3F4R A;  5F91 A;  2JAR A;  3CI0 K;  4FLC A;  1XL8 A;  4E88 A;  2O7E A;  1XLY A;  3F4T A;  1Z4I A;  1I0A A;  2VSF A;  3GTD A;  1FUQ A;  3E04 A;  2OHY A;  2VL7 A;  5D6B A;  3CZO A;  1TJ7 A;  4C5S A;  1J3U A;  2JAW A;  1TJU A;  3R6Y A;  4APB A;  1GKJ A;  4BAB A;  1EB4 A;  4L6A A;  3RD8 A;  2PTQ A;  3BWV A;  1T6P A;  4L6C A;  3RRP A;  1RE5 A;  2D27 A;  1Z4K A;  3C8T A;  2RJR A;  2YII A;  2O7F A;  1AUW A;  1Q92 A;  4V2Q A;  1Z4L A;  1U16 A;  2O78 A;  1VDK A;  4YIK A;  3KDZ A;  3OCE A;  3TV2 A;  1GK2 A;  4C6G A;  4NLE A;  1C3U A;  1YIS A;  3NZ4 A;  1TJW A;  1Z4J A;  3R6Q A;  3R6V A;  1IW7 D;  1MH9 A;  1GK3 A;  5M0I A;  2JAU A;  3NO9 A;  2NYF A;  1HY1 A;  3CRW 1;  1Z4Q A;  2E9F A;  2PFM A;  1FUR A; 
#chains in the Genus database with same CATH homology
 1JSW A;  1U15 A;  1Q5N A;  1GKM A;  2NYN A;  4HGV A;  1FUP A;  3KDY A;  2FUS A;  1W27 A;  1B8F A;  1KQ7 A;  4EEI A;  2PTS A;  2J91 A;  1C3C A;  4C5R A;  1YFM A;  2O6Y A;  1DCN A;  2RJS A;  1Y2M A;  5F92 A;  2VD6 A;  5EYV A;  1K62 A;  3UNV A;  3GZH A;  4CQ5 A;  3OCF A;  1XWO A;  1HY0 A;  4NSL A;  2O7B A;  2PTR A;  3QBP A;  1FUO A;  4ADM A;  2O7D A;  4C5U A;  2X75 A;  2QVE A;  1T6J A;  3BHG A;  1YFE A;  1TJV A;  4MX2 A;  4V2R A;  4APA A;  5EYT A;  4EFC A;  4FFX A;  2HVG A;  4ADL A;  5HW2 A;  1DOF A;  2QGA B;  4BAA A;  1K7W A;  5F91 A;  4FLC A;  2O7E A;  1I0A A;  3GTD A;  1FUQ A;  3E04 A;  2OHY A;  5D6B A;  3CZO A;  1TJ7 A;  4C5S A;  1J3U A;  1TJU A;  3R6Y A;  4APB A;  1GKJ A;  4BAB A;  1EB4 A;  3RD8 A;  2PTQ A;  1T6P A;  3RRP A;  1RE5 A;  3C8T A;  2RJR A;  2YII A;  2O7F A;  1AUW A;  4V2Q A;  1U16 A;  2O78 A;  1VDK A;  3KDZ A;  3OCE A;  3TV2 A;  1GK2 A;  4C6G A;  4NLE A;  1C3U A;  1YIS A;  3NZ4 A;  1TJW A;  3R6Q A;  3R6V A;  1GK3 A;  3NO9 A;  2NYF A;  1HY1 A;  2E9F A;  2PFM A;  1FUR A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...