5F92A

Fumarate hydratase of mycobacterium tuberculosis in complex with formate
Total Genus 179
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
179
sequence length
460
structure length
460
Chain Sequence
YRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
pubmed doi rcsb
source organism Mycobacterium tuberculosis (strain cdc 1551 / oshkosh)
molecule tags Lyase
molecule keywords Fumarate hydratase class II
total genus 179
structure length 460
sequence length 460
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2015-12-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 5f92A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 5f92A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 5f92A02
4BABA 3R6VA 4V2QA 2PTQA 3E04A 4C6GA 1JSWA 4EFCA 2RJSA 1Q5NA 4MX2A 2O7FA 4HGVA 5F92A 5EYVA 1T6JA 1YFMA 4BAAA 1AUWA 3NO9A 1FUPA 1B8FA 2HVGA 4C5SA 3KDZA 1I0AA 5HW2A 2J91A 1GKJA 4ADMA 1FURA 5F91A 1TJUA 1GK3A 2QVEA 1TJ7A 3C8TA 2NYNA 2O6YA 1FUOA 4NSLA 1TJWA 3GTDA 4APAA 3OCFA 4C5UA 3NZ4A 2RJRA 1T6PA 3UNVA 1KQ7A 3RD8A 4FFXA 1HY1A 2OHYA 2NYFA 1GK2A 2E9FA 5EYTA 3TV2A 1HY0A 5D6BA 4V2RA 1EB4A 3R6QA 2FUSA 2PFMA 2PTSA 2O78A 1DCNA 1C3UA 1J3UA 3OCEA 4APBA 2O7BA 4CQ5A 1XWOA 3QBPA 1K62A 1VDKA 4ADLA 2X75A 2QGAB 3KDYA 1RE5A 1U16A 1YFEA 4EEIA 1Y2MA 1YISA 1FUQA 1DOFA 3RRPA 1U15A 1TJVA 4FLCA 3GZHA 1K7WA 1C3CA 3CZOA 3BHGA 2VD6A 2YIIA 1GKMA 2O7EA 2O7DA 1W27A 3R6YA 2PTRA 4NLEA 4C5RA
chains in the Genus database with same CATH superfamily
4BABA 1Z4JA 3R6VA 1Z4PX 4V2QA 3U13A 2PTQA 1IW7D 3E04A 1XL7A 3CRVA 3CRW1 4C6GA 1JSWA 4EFCA 2RJSA 1Q5NA 4MX2A 2O7FA 4HGVA 5F92A 4E88A 1T9HA 1Z4LA 5EYVA 1T6JA 1YFMA 4BAAA 2D28C 1AUWA 3NO9A 1FUPA 1B8FA 2HVGA 3U19A 4C5SA 4IQJM 3KDZA 1I0AA 5HW2A 3F4RA 2J91A 1XLYA 1GKJA 4ADMA 1FURA 5F91A 1TJUA 2YV5A 4L6CA 1GK3A 2QVEA 1TJ7A 2FENA 1Z4KA 3C8TA 2NYNA 4WNLA 2O6YA 1FUOA 4NSLA 2RCNA 4YIHA 1TJWA 2FELA 3GTDA 2JAOA 4APAA 1U0LA 3OCFA 4C5UA 1Z4IA 3NZ4A 4L6AA 5M0IA 4L57A 4MWOA 2RJRA 1Z4QA 1T6PA 5H8WA 4YIKA 3UNVA 1KQ7A 3RD8A 4FFXA 1HY1A 2OHYA 2NYFA 3F4SA 3BWVA 1GK2A 2E9FA 1MH9A 5EYTA 3TV2A 4NFLA 1HY0A 5D6BA 4V2RA 1EB4A 2D27A 2JAWA 2JARA 2FUSA 3R6QA 2PFMA 2PTSA 2O78A 3F4TA 2JAUA 1DCNA 1C3UA 1J3UA 3OCEA 3CI0K 1XMCA 4APBA 2O7BA 1XMDA 4CQ5A 1XWOA 3QBPA 1K62A 1VDKA 4ADLA 2VL7A 2X75A 2QGAB 3KDYA 1RE5A 1U16A 1YFEA 4EEIA 1Y2MA 1YISA 4A15A 4MUMA 1FUQA 2VSFA 1DOFA 1Q92A 3RRPA 1U15A 1TJVA 4FLCA 3GZHA 1K7WA 1Q91A 1C3CA 3CZOA 2I7DA 3BHGA 2VD6A 2YIIA 1GKMA 2O7EA 2O7DA 5M0JA 1Z4MA 1W27A 3R6YA 2PTRA 4NLEA 4C5RA 1XL8A
chains in the Genus database with same CATH topology
4BABA 3R6VA 4V2QA 2PTQA 3E04A 4C6GA 1JSWA 4EFCA 2RJSA 1Q5NA 4MX2A 2O7FA 4HGVA 5F92A 5EYVA 1T6JA 1YFMA 4BAAA 1AUWA 3NO9A 1FUPA 1B8FA 2HVGA 4C5SA 3KDZA 1I0AA 5HW2A 2J91A 1GKJA 4ADMA 1FURA 5F91A 1TJUA 1GK3A 2QVEA 1TJ7A 3C8TA 2NYNA 2O6YA 1FUOA 4NSLA 1TJWA 3GTDA 4APAA 3OCFA 4C5UA 3NZ4A 2RJRA 1T6PA 3UNVA 1KQ7A 3RD8A 4FFXA 1HY1A 2OHYA 2NYFA 1GK2A 2E9FA 5EYTA 3TV2A 1HY0A 5D6BA 4V2RA 1EB4A 3R6QA 2FUSA 2PFMA 2PTSA 2O78A 1DCNA 1C3UA 1J3UA 3OCEA 4APBA 2O7BA 4CQ5A 1XWOA 3QBPA 1K62A 1VDKA 4ADLA 2X75A 2QGAB 3KDYA 1RE5A 1U16A 1YFEA 4EEIA 1Y2MA 1YISA 1FUQA 1DOFA 3RRPA 1U15A 1TJVA 4FLCA 3GZHA 1K7WA 1C3CA 3CZOA 3BHGA 2VD6A 2YIIA 1GKMA 2O7EA 2O7DA 1W27A 3R6YA 2PTRA 4NLEA 4C5RA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BAB A;  3R6V A;  4V2Q A;  2PTQ A;  3E04 A;  4C6G A;  1JSW A;  4EFC A;  2RJS A;  1Q5N A;  4MX2 A;  2O7F A;  4HGV A;  5F92 A;  5EYV A;  1T6J A;  1YFM A;  4BAA A;  1AUW A;  3NO9 A;  1FUP A;  1B8F A;  2HVG A;  4C5S A;  3KDZ A;  1I0A A;  5HW2 A;  2J91 A;  1GKJ A;  4ADM A;  1FUR A;  5F91 A;  1TJU A;  1GK3 A;  2QVE A;  1TJ7 A;  3C8T A;  2NYN A;  2O6Y A;  1FUO A;  4NSL A;  1TJW A;  3GTD A;  4APA A;  3OCF A;  4C5U A;  3NZ4 A;  2RJR A;  1T6P A;  3UNV A;  1KQ7 A;  3RD8 A;  4FFX A;  1HY1 A;  2OHY A;  2NYF A;  1GK2 A;  2E9F A;  5EYT A;  3TV2 A;  1HY0 A;  5D6B A;  4V2R A;  1EB4 A;  3R6Q A;  2FUS A;  2PFM A;  2PTS A;  2O78 A;  1DCN A;  1C3U A;  1J3U A;  3OCE A;  4APB A;  2O7B A;  4CQ5 A;  1XWO A;  3QBP A;  1K62 A;  1VDK A;  4ADL A;  2X75 A;  2QGA B;  3KDY A;  1RE5 A;  1U16 A;  1YFE A;  4EEI A;  1Y2M A;  1YIS A;  1FUQ A;  1DOF A;  3RRP A;  1U15 A;  1TJV A;  4FLC A;  3GZH A;  1K7W A;  1C3C A;  3CZO A;  3BHG A;  2VD6 A;  2YII A;  1GKM A;  2O7E A;  2O7D A;  1W27 A;  3R6Y A;  2PTR A;  4NLE A;  4C5R A; 
#chains in the Genus database with same CATH topology
 4BAB A;  1Z4J A;  3R6V A;  1Z4P X;  4V2Q A;  3U13 A;  2PTQ A;  1IW7 D;  3E04 A;  1XL7 A;  3CRV A;  3CRW 1;  4C6G A;  1JSW A;  4EFC A;  2RJS A;  1Q5N A;  4MX2 A;  2O7F A;  4HGV A;  5F92 A;  4E88 A;  1T9H A;  1Z4L A;  5EYV A;  1T6J A;  1YFM A;  4BAA A;  2D28 C;  1AUW A;  3NO9 A;  1FUP A;  1B8F A;  2HVG A;  3U19 A;  4C5S A;  4IQJ M;  3KDZ A;  1I0A A;  5HW2 A;  3F4R A;  2J91 A;  1XLY A;  1GKJ A;  4ADM A;  1FUR A;  5F91 A;  1TJU A;  2YV5 A;  4L6C A;  1GK3 A;  2QVE A;  1TJ7 A;  2FEN A;  1Z4K A;  3C8T A;  2NYN A;  4WNL A;  2O6Y A;  1FUO A;  4NSL A;  2RCN A;  4YIH A;  1TJW A;  2FEL A;  3GTD A;  2JAO A;  4APA A;  1U0L A;  3OCF A;  4C5U A;  1Z4I A;  3NZ4 A;  4L6A A;  5M0I A;  4L57 A;  4MWO A;  2RJR A;  1Z4Q A;  1T6P A;  5H8W A;  4YIK A;  3UNV A;  1KQ7 A;  3RD8 A;  4FFX A;  1HY1 A;  2OHY A;  2NYF A;  3F4S A;  3BWV A;  1GK2 A;  2E9F A;  1MH9 A;  5EYT A;  3TV2 A;  4NFL A;  1HY0 A;  5D6B A;  4V2R A;  1EB4 A;  2D27 A;  2JAW A;  2JAR A;  2FUS A;  3R6Q A;  2PFM A;  2PTS A;  2O78 A;  3F4T A;  2JAU A;  1DCN A;  1C3U A;  1J3U A;  3OCE A;  3CI0 K;  1XMC A;  4APB A;  2O7B A;  1XMD A;  4CQ5 A;  1XWO A;  3QBP A;  1K62 A;  1VDK A;  4ADL A;  2VL7 A;  2X75 A;  2QGA B;  3KDY A;  1RE5 A;  1U16 A;  1YFE A;  4EEI A;  1Y2M A;  1YIS A;  4A15 A;  4MUM A;  1FUQ A;  2VSF A;  1DOF A;  1Q92 A;  3RRP A;  1U15 A;  1TJV A;  4FLC A;  3GZH A;  1K7W A;  1Q91 A;  1C3C A;  3CZO A;  2I7D A;  3BHG A;  2VD6 A;  2YII A;  1GKM A;  2O7E A;  2O7D A;  5M0J A;  1Z4M A;  1W27 A;  3R6Y A;  2PTR A;  4NLE A;  4C5R A;  1XL8 A; 
#chains in the Genus database with same CATH homology
 4BAB A;  3R6V A;  4V2Q A;  2PTQ A;  3E04 A;  4C6G A;  1JSW A;  4EFC A;  2RJS A;  1Q5N A;  4MX2 A;  2O7F A;  4HGV A;  5F92 A;  5EYV A;  1T6J A;  1YFM A;  4BAA A;  1AUW A;  3NO9 A;  1FUP A;  1B8F A;  2HVG A;  4C5S A;  3KDZ A;  1I0A A;  5HW2 A;  2J91 A;  1GKJ A;  4ADM A;  1FUR A;  5F91 A;  1TJU A;  1GK3 A;  2QVE A;  1TJ7 A;  3C8T A;  2NYN A;  2O6Y A;  1FUO A;  4NSL A;  1TJW A;  3GTD A;  4APA A;  3OCF A;  4C5U A;  3NZ4 A;  2RJR A;  1T6P A;  3UNV A;  1KQ7 A;  3RD8 A;  4FFX A;  1HY1 A;  2OHY A;  2NYF A;  1GK2 A;  2E9F A;  5EYT A;  3TV2 A;  1HY0 A;  5D6B A;  4V2R A;  1EB4 A;  3R6Q A;  2FUS A;  2PFM A;  2PTS A;  2O78 A;  1DCN A;  1C3U A;  1J3U A;  3OCE A;  4APB A;  2O7B A;  4CQ5 A;  1XWO A;  3QBP A;  1K62 A;  1VDK A;  4ADL A;  2X75 A;  2QGA B;  3KDY A;  1RE5 A;  1U16 A;  1YFE A;  4EEI A;  1Y2M A;  1YIS A;  1FUQ A;  1DOF A;  3RRP A;  1U15 A;  1TJV A;  4FLC A;  3GZH A;  1K7W A;  1C3C A;  3CZO A;  3BHG A;  2VD6 A;  2YII A;  1GKM A;  2O7E A;  2O7D A;  1W27 A;  3R6Y A;  2PTR A;  4NLE A;  4C5R A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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