5F92A

Fumarate hydratase of mycobacterium tuberculosis in complex with formate
Total Genus 179
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
179
sequence length
460
structure length
460
Chain Sequence
YRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Fumarate hydratase class II
publication title Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
pubmed doi rcsb
source organism Mycobacterium tuberculosis (strain cdc 1551 / oshkosh)
molecule tags Lyase
total genus 179
structure length 460
sequence length 460
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2015-12-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 5f92A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 5f92A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 5f92A02
3RRPA 1DOFA 4APAA 1VDKA 4EFCA 4MX2A 2O7FA 1GK2A 1K7WA 4NSLA 3RD8A 1TJUA 3R6QA 1B8FA 2QGAB 4FLCA 3E04A 4HGVA 1C3UA 4ADMA 2RJRA 2VD6A 3TV2A 1YFMA 2O6YA 5F91A 2J91A 1J3UA 2HVGA 2E9FA 1TJVA 1YFEA 3KDYA 4C5RA 1FUQA 3C8TA 5HW2A 2O7BA 1T6PA 2FUSA 4NLEA 1GK3A 3QBPA 2X75A 4FFXA 1Q5NA 4BABA 2YIIA 3BHGA 3CZOA 3NZ4A 5EYVA 1FUOA 4APBA 1T6JA 2O7EA 4ADLA 1GKJA 2RJSA 3KDZA 4BAAA 1W27A 3OCFA 1JSWA 1K62A 5EYTA 1GKMA 4C6GA 1TJWA 4C5UA 2PFMA 3OCEA 1C3CA 2PTRA 2NYFA 4V2RA 1AUWA 1YISA 1XWOA 4CQ5A 2PTSA 2PTQA 2O78A 3R6VA 1KQ7A 1EB4A 2NYNA 1RE5A 2O7DA 1DCNA 1TJ7A 3GZHA 1FUPA 1Y2MA 1HY0A 1U15A 1U16A 3NO9A 4C5SA 2QVEA 5F92A 3UNVA 1I0AA 4EEIA 2OHYA 1FURA 3R6YA 1HY1A 4V2QA 3GTDA 5D6BA
chains in the Genus database with same CATH superfamily
1Z4IA 3RRPA 1DOFA 4APAA 1VDKA 4EFCA 4MX2A 2O7FA 1GK2A 1K7WA 4NSLA 3RD8A 1Z4LA 1TJUA 3R6QA 1B8FA 2QGAB 4YIHA 3CRW1 3CI0K 4FLCA 3E04A 4HGVA 1C3UA 2FENA 4ADMA 2RJRA 2VD6A 3TV2A 2FELA 1YFMA 4L6AA 2O6YA 5F91A 2J91A 1J3UA 2HVGA 2E9FA 2JAOA 1TJVA 2JAUA 1YFEA 3KDYA 4A15A 1T9HA 4C5RA 2VSFA 1FUQA 3C8TA 5HW2A 2D27A 4YIKA 2O7BA 1T6PA 2FUSA 4NLEA 1GK3A 3QBPA 1Z4MA 2X75A 4E88A 4FFXA 1Q5NA 4WNLA 2I7DA 4BABA 1MH9A 2YIIA 4MUMA 5M0JA 3BHGA 1XLYA 3CZOA 5H8WA 3NZ4A 5EYVA 1FUOA 2YV5A 3CRVA 4APBA 3BWVA 1T6JA 1XMCA 2O7EA 4ADLA 1GKJA 2RJSA 3KDZA 4BAAA 1W27A 4MWOA 3OCFA 1JSWA 1K62A 5EYTA 1GKMA 2JAWA 1TJWA 4C6GA 4C5UA 2PFMA 1XL8A 3OCEA 1Z4QA 1C3CA 2PTRA 2NYFA 4V2RA 3F4RA 5M0IA 1AUWA 1YISA 3F4TA 4L57A 1Z4JA 1XWOA 2RCNA 4CQ5A 2PTSA 2PTQA 2O78A 1Q92A 3R6VA 1IW7D 1KQ7A 1EB4A 2NYNA 1RE5A 2O7DA 2JARA 1DCNA 1TJ7A 3F4SA 3U19A 3GZHA 1FUPA 1Q91A 1U0LA 4NFLA 1Y2MA 1XL7A 1HY0A 1Z4PX 1U15A 1U16A 3NO9A 4IQJM 4C5SA 4L6CA 2D28C 2QVEA 5F92A 3UNVA 1I0AA 1XMDA 4EEIA 1Z4KA 2OHYA 1FURA 3R6YA 1HY1A 3U13A 4V2QA 3GTDA 2VL7A 5D6BA
chains in the Genus database with same CATH topology
3RRPA 1DOFA 4APAA 1VDKA 4EFCA 4MX2A 2O7FA 1GK2A 1K7WA 4NSLA 3RD8A 1TJUA 3R6QA 1B8FA 2QGAB 4FLCA 3E04A 4HGVA 1C3UA 4ADMA 2RJRA 2VD6A 3TV2A 1YFMA 2O6YA 5F91A 2J91A 1J3UA 2HVGA 2E9FA 1TJVA 1YFEA 3KDYA 4C5RA 1FUQA 3C8TA 5HW2A 2O7BA 1T6PA 2FUSA 4NLEA 1GK3A 3QBPA 2X75A 4FFXA 1Q5NA 4BABA 2YIIA 3BHGA 3CZOA 3NZ4A 5EYVA 1FUOA 4APBA 1T6JA 2O7EA 4ADLA 1GKJA 2RJSA 3KDZA 4BAAA 1W27A 3OCFA 1JSWA 1K62A 5EYTA 1GKMA 4C6GA 1TJWA 4C5UA 2PFMA 3OCEA 1C3CA 2PTRA 2NYFA 4V2RA 1AUWA 1YISA 1XWOA 4CQ5A 2PTSA 2PTQA 2O78A 3R6VA 1KQ7A 1EB4A 2NYNA 1RE5A 2O7DA 1DCNA 1TJ7A 3GZHA 1FUPA 1Y2MA 1HY0A 1U15A 1U16A 3NO9A 4C5SA 2QVEA 5F92A 3UNVA 1I0AA 4EEIA 2OHYA 1FURA 3R6YA 1HY1A 4V2QA 3GTDA 5D6BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3RRP A;  1DOF A;  4APA A;  1VDK A;  4EFC A;  4MX2 A;  2O7F A;  1GK2 A;  1K7W A;  4NSL A;  3RD8 A;  1TJU A;  3R6Q A;  1B8F A;  2QGA B;  4FLC A;  3E04 A;  4HGV A;  1C3U A;  4ADM A;  2RJR A;  2VD6 A;  3TV2 A;  1YFM A;  2O6Y A;  5F91 A;  2J91 A;  1J3U A;  2HVG A;  2E9F A;  1TJV A;  1YFE A;  3KDY A;  4C5R A;  1FUQ A;  3C8T A;  5HW2 A;  2O7B A;  1T6P A;  2FUS A;  4NLE A;  1GK3 A;  3QBP A;  2X75 A;  4FFX A;  1Q5N A;  4BAB A;  2YII A;  3BHG A;  3CZO A;  3NZ4 A;  5EYV A;  1FUO A;  4APB A;  1T6J A;  2O7E A;  4ADL A;  1GKJ A;  2RJS A;  3KDZ A;  4BAA A;  1W27 A;  3OCF A;  1JSW A;  1K62 A;  5EYT A;  1GKM A;  4C6G A;  1TJW A;  4C5U A;  2PFM A;  3OCE A;  1C3C A;  2PTR A;  2NYF A;  4V2R A;  1AUW A;  1YIS A;  1XWO A;  4CQ5 A;  2PTS A;  2PTQ A;  2O78 A;  3R6V A;  1KQ7 A;  1EB4 A;  2NYN A;  1RE5 A;  2O7D A;  1DCN A;  1TJ7 A;  3GZH A;  1FUP A;  1Y2M A;  1HY0 A;  1U15 A;  1U16 A;  3NO9 A;  4C5S A;  2QVE A;  5F92 A;  3UNV A;  1I0A A;  4EEI A;  2OHY A;  1FUR A;  3R6Y A;  1HY1 A;  4V2Q A;  3GTD A;  5D6B A; 
#chains in the Genus database with same CATH topology
 1Z4I A;  3RRP A;  1DOF A;  4APA A;  1VDK A;  4EFC A;  4MX2 A;  2O7F A;  1GK2 A;  1K7W A;  4NSL A;  3RD8 A;  1Z4L A;  1TJU A;  3R6Q A;  1B8F A;  2QGA B;  4YIH A;  3CRW 1;  3CI0 K;  4FLC A;  3E04 A;  4HGV A;  1C3U A;  2FEN A;  4ADM A;  2RJR A;  2VD6 A;  3TV2 A;  2FEL A;  1YFM A;  4L6A A;  2O6Y A;  5F91 A;  2J91 A;  1J3U A;  2HVG A;  2E9F A;  2JAO A;  1TJV A;  2JAU A;  1YFE A;  3KDY A;  4A15 A;  1T9H A;  4C5R A;  2VSF A;  1FUQ A;  3C8T A;  5HW2 A;  2D27 A;  4YIK A;  2O7B A;  1T6P A;  2FUS A;  4NLE A;  1GK3 A;  3QBP A;  1Z4M A;  2X75 A;  4E88 A;  4FFX A;  1Q5N A;  4WNL A;  2I7D A;  4BAB A;  1MH9 A;  2YII A;  4MUM A;  5M0J A;  3BHG A;  1XLY A;  3CZO A;  5H8W A;  3NZ4 A;  5EYV A;  1FUO A;  2YV5 A;  3CRV A;  4APB A;  3BWV A;  1T6J A;  1XMC A;  2O7E A;  4ADL A;  1GKJ A;  2RJS A;  3KDZ A;  4BAA A;  1W27 A;  4MWO A;  3OCF A;  1JSW A;  1K62 A;  5EYT A;  1GKM A;  2JAW A;  1TJW A;  4C6G A;  4C5U A;  2PFM A;  1XL8 A;  3OCE A;  1Z4Q A;  1C3C A;  2PTR A;  2NYF A;  4V2R A;  3F4R A;  5M0I A;  1AUW A;  1YIS A;  3F4T A;  4L57 A;  1Z4J A;  1XWO A;  2RCN A;  4CQ5 A;  2PTS A;  2PTQ A;  2O78 A;  1Q92 A;  3R6V A;  1IW7 D;  1KQ7 A;  1EB4 A;  2NYN A;  1RE5 A;  2O7D A;  2JAR A;  1DCN A;  1TJ7 A;  3F4S A;  3U19 A;  3GZH A;  1FUP A;  1Q91 A;  1U0L A;  4NFL A;  1Y2M A;  1XL7 A;  1HY0 A;  1Z4P X;  1U15 A;  1U16 A;  3NO9 A;  4IQJ M;  4C5S A;  4L6C A;  2D28 C;  2QVE A;  5F92 A;  3UNV A;  1I0A A;  1XMD A;  4EEI A;  1Z4K A;  2OHY A;  1FUR A;  3R6Y A;  1HY1 A;  3U13 A;  4V2Q A;  3GTD A;  2VL7 A;  5D6B A; 
#chains in the Genus database with same CATH homology
 3RRP A;  1DOF A;  4APA A;  1VDK A;  4EFC A;  4MX2 A;  2O7F A;  1GK2 A;  1K7W A;  4NSL A;  3RD8 A;  1TJU A;  3R6Q A;  1B8F A;  2QGA B;  4FLC A;  3E04 A;  4HGV A;  1C3U A;  4ADM A;  2RJR A;  2VD6 A;  3TV2 A;  1YFM A;  2O6Y A;  5F91 A;  2J91 A;  1J3U A;  2HVG A;  2E9F A;  1TJV A;  1YFE A;  3KDY A;  4C5R A;  1FUQ A;  3C8T A;  5HW2 A;  2O7B A;  1T6P A;  2FUS A;  4NLE A;  1GK3 A;  3QBP A;  2X75 A;  4FFX A;  1Q5N A;  4BAB A;  2YII A;  3BHG A;  3CZO A;  3NZ4 A;  5EYV A;  1FUO A;  4APB A;  1T6J A;  2O7E A;  4ADL A;  1GKJ A;  2RJS A;  3KDZ A;  4BAA A;  1W27 A;  3OCF A;  1JSW A;  1K62 A;  5EYT A;  1GKM A;  4C6G A;  1TJW A;  4C5U A;  2PFM A;  3OCE A;  1C3C A;  2PTR A;  2NYF A;  4V2R A;  1AUW A;  1YIS A;  1XWO A;  4CQ5 A;  2PTS A;  2PTQ A;  2O78 A;  3R6V A;  1KQ7 A;  1EB4 A;  2NYN A;  1RE5 A;  2O7D A;  1DCN A;  1TJ7 A;  3GZH A;  1FUP A;  1Y2M A;  1HY0 A;  1U15 A;  1U16 A;  3NO9 A;  4C5S A;  2QVE A;  5F92 A;  3UNV A;  1I0A A;  4EEI A;  2OHY A;  1FUR A;  3R6Y A;  1HY1 A;  4V2Q A;  3GTD A;  5D6B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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