5F92A

Fumarate hydratase of mycobacterium tuberculosis in complex with formate
Total Genus 179
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
179
sequence length
460
structure length
460
Chain Sequence
YRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
pubmed doi rcsb
source organism Mycobacterium tuberculosis (strain cdc 1551 / oshkosh)
molecule tags Lyase
molecule keywords Fumarate hydratase class II
total genus 179
structure length 460
sequence length 460
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2015-12-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 5f92A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 5f92A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 5f92A02
1C3UA 2OHYA 1HY1A 1JSWA 4NSLA 1GKJA 4BAAA 1GK2A 4C5UA 4ADMA 2QGAB 2O78A 2O7EA 2O7BA 1DOFA 1TJVA 2PTSA 2O6YA 2RJRA 1TJUA 5EYTA 1YFMA 1GKMA 3QBPA 2QVEA 3OCFA 1Y2MA 4ADLA 1FUOA 3R6QA 4V2RA 1EB4A 4BABA 4CQ5A 3GZHA 5D6BA 2RJSA 3KDZA 1FUPA 5F91A 2PTRA 2PTQA 1T6PA 4HGVA 3KDYA 1YFEA 3NZ4A 4FFXA 3C8TA 1Q5NA 1DCNA 4APAA 4FLCA 5HW2A 3OCEA 2O7DA 4EFCA 1VDKA 2J91A 1HY0A 3R6VA 1XWOA 1TJWA 2PFMA 4APBA 2X75A 3BHGA 1U16A 4V2QA 2NYNA 2YIIA 1I0AA 3CZOA 4EEIA 2HVGA 5EYVA 3UNVA 1T6JA 1AUWA 5F92A 4MX2A 1YISA 1RE5A 2E9FA 3E04A 3GTDA 1FUQA 1K62A 2NYFA 3R6YA 1K7WA 4NLEA 1B8FA 2VD6A 4C6GA 3NO9A 1TJ7A 1KQ7A 4C5SA 1U15A 2FUSA 3RD8A 2O7FA 1GK3A 1W27A 1J3UA 3TV2A 3RRPA 1C3CA 4C5RA 1FURA
chains in the Genus database with same CATH superfamily
1C3UA 2OHYA 1HY1A 1JSWA 4NSLA 1GKJA 4BAAA 1GK2A 1MH9A 4C5UA 4ADMA 4L57A 2QGAB 2O78A 3F4SA 2O7EA 1Z4LA 1U0LA 1DOFA 2O7BA 1TJVA 2PTSA 2O6YA 1Z4QA 4WNLA 2RJRA 1TJUA 5EYTA 4L6AA 3CRVA 1Q91A 1YFMA 2FELA 1XMDA 1GKMA 3QBPA 2QVEA 3OCFA 4YIKA 1XL8A 4A15A 1Y2MA 4ADLA 1FUOA 3BWVA 4L6CA 3R6QA 4V2RA 1EB4A 4BABA 4CQ5A 3GZHA 5D6BA 2RJSA 3KDZA 1FUPA 5F91A 2PTRA 2PTQA 1XL7A 1T6PA 4HGVA 3KDYA 1YFEA 3NZ4A 4FFXA 3C8TA 1Q5NA 4YIHA 1DCNA 4APAA 4FLCA 2RCNA 5HW2A 3OCEA 5H8WA 4MUMA 2O7DA 4EFCA 1VDKA 2J91A 1Z4KA 1HY0A 3R6VA 1XWOA 1TJWA 2PFMA 2JAUA 4APBA 2X75A 3BHGA 1XLYA 1U16A 4NFLA 5M0IA 4V2QA 5M0JA 2NYNA 2YIIA 1Z4IA 1I0AA 3CZOA 1Q92A 4EEIA 1XMCA 2JARA 2HVGA 3CI0K 5EYVA 1Z4PX 3UNVA 1T6JA 2YV5A 2JAOA 1AUWA 5F92A 4E88A 4MX2A 1YISA 1RE5A 3F4TA 1T9HA 2E9FA 3E04A 3GTDA 1FUQA 2VL7A 1K62A 3F4RA 3CRW1 2NYFA 2JAWA 3R6YA 2I7DA 4MWOA 1K7WA 4NLEA 4IQJM 1IW7D 1B8FA 2VD6A 4C6GA 1Z4JA 3NO9A 1TJ7A 3U19A 1Z4MA 1KQ7A 4C5SA 1U15A 2FUSA 3RD8A 2O7FA 1GK3A 1W27A 3U13A 1J3UA 3TV2A 2FENA 3RRPA 1C3CA 2D27A 2VSFA 4C5RA 2D28C 1FURA
chains in the Genus database with same CATH topology
1C3UA 2OHYA 1HY1A 1JSWA 4NSLA 1GKJA 4BAAA 1GK2A 4C5UA 4ADMA 2QGAB 2O78A 2O7EA 2O7BA 1DOFA 1TJVA 2PTSA 2O6YA 2RJRA 1TJUA 5EYTA 1YFMA 1GKMA 3QBPA 2QVEA 3OCFA 1Y2MA 4ADLA 1FUOA 3R6QA 4V2RA 1EB4A 4BABA 4CQ5A 3GZHA 5D6BA 2RJSA 3KDZA 1FUPA 5F91A 2PTRA 2PTQA 1T6PA 4HGVA 3KDYA 1YFEA 3NZ4A 4FFXA 3C8TA 1Q5NA 1DCNA 4APAA 4FLCA 5HW2A 3OCEA 2O7DA 4EFCA 1VDKA 2J91A 1HY0A 3R6VA 1XWOA 1TJWA 2PFMA 4APBA 2X75A 3BHGA 1U16A 4V2QA 2NYNA 2YIIA 1I0AA 3CZOA 4EEIA 2HVGA 5EYVA 3UNVA 1T6JA 1AUWA 5F92A 4MX2A 1YISA 1RE5A 2E9FA 3E04A 3GTDA 1FUQA 1K62A 2NYFA 3R6YA 1K7WA 4NLEA 1B8FA 2VD6A 4C6GA 3NO9A 1TJ7A 1KQ7A 4C5SA 1U15A 2FUSA 3RD8A 2O7FA 1GK3A 1W27A 1J3UA 3TV2A 3RRPA 1C3CA 4C5RA 1FURA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C3U A;  2OHY A;  1HY1 A;  1JSW A;  4NSL A;  1GKJ A;  4BAA A;  1GK2 A;  4C5U A;  4ADM A;  2QGA B;  2O78 A;  2O7E A;  2O7B A;  1DOF A;  1TJV A;  2PTS A;  2O6Y A;  2RJR A;  1TJU A;  5EYT A;  1YFM A;  1GKM A;  3QBP A;  2QVE A;  3OCF A;  1Y2M A;  4ADL A;  1FUO A;  3R6Q A;  4V2R A;  1EB4 A;  4BAB A;  4CQ5 A;  3GZH A;  5D6B A;  2RJS A;  3KDZ A;  1FUP A;  5F91 A;  2PTR A;  2PTQ A;  1T6P A;  4HGV A;  3KDY A;  1YFE A;  3NZ4 A;  4FFX A;  3C8T A;  1Q5N A;  1DCN A;  4APA A;  4FLC A;  5HW2 A;  3OCE A;  2O7D A;  4EFC A;  1VDK A;  2J91 A;  1HY0 A;  3R6V A;  1XWO A;  1TJW A;  2PFM A;  4APB A;  2X75 A;  3BHG A;  1U16 A;  4V2Q A;  2NYN A;  2YII A;  1I0A A;  3CZO A;  4EEI A;  2HVG A;  5EYV A;  3UNV A;  1T6J A;  1AUW A;  5F92 A;  4MX2 A;  1YIS A;  1RE5 A;  2E9F A;  3E04 A;  3GTD A;  1FUQ A;  1K62 A;  2NYF A;  3R6Y A;  1K7W A;  4NLE A;  1B8F A;  2VD6 A;  4C6G A;  3NO9 A;  1TJ7 A;  1KQ7 A;  4C5S A;  1U15 A;  2FUS A;  3RD8 A;  2O7F A;  1GK3 A;  1W27 A;  1J3U A;  3TV2 A;  3RRP A;  1C3C A;  4C5R A;  1FUR A; 
#chains in the Genus database with same CATH topology
 1C3U A;  2OHY A;  1HY1 A;  1JSW A;  4NSL A;  1GKJ A;  4BAA A;  1GK2 A;  1MH9 A;  4C5U A;  4ADM A;  4L57 A;  2QGA B;  2O78 A;  3F4S A;  2O7E A;  1Z4L A;  1U0L A;  1DOF A;  2O7B A;  1TJV A;  2PTS A;  2O6Y A;  1Z4Q A;  4WNL A;  2RJR A;  1TJU A;  5EYT A;  4L6A A;  3CRV A;  1Q91 A;  1YFM A;  2FEL A;  1XMD A;  1GKM A;  3QBP A;  2QVE A;  3OCF A;  4YIK A;  1XL8 A;  4A15 A;  1Y2M A;  4ADL A;  1FUO A;  3BWV A;  4L6C A;  3R6Q A;  4V2R A;  1EB4 A;  4BAB A;  4CQ5 A;  3GZH A;  5D6B A;  2RJS A;  3KDZ A;  1FUP A;  5F91 A;  2PTR A;  2PTQ A;  1XL7 A;  1T6P A;  4HGV A;  3KDY A;  1YFE A;  3NZ4 A;  4FFX A;  3C8T A;  1Q5N A;  4YIH A;  1DCN A;  4APA A;  4FLC A;  2RCN A;  5HW2 A;  3OCE A;  5H8W A;  4MUM A;  2O7D A;  4EFC A;  1VDK A;  2J91 A;  1Z4K A;  1HY0 A;  3R6V A;  1XWO A;  1TJW A;  2PFM A;  2JAU A;  4APB A;  2X75 A;  3BHG A;  1XLY A;  1U16 A;  4NFL A;  5M0I A;  4V2Q A;  5M0J A;  2NYN A;  2YII A;  1Z4I A;  1I0A A;  3CZO A;  1Q92 A;  4EEI A;  1XMC A;  2JAR A;  2HVG A;  3CI0 K;  5EYV A;  1Z4P X;  3UNV A;  1T6J A;  2YV5 A;  2JAO A;  1AUW A;  5F92 A;  4E88 A;  4MX2 A;  1YIS A;  1RE5 A;  3F4T A;  1T9H A;  2E9F A;  3E04 A;  3GTD A;  1FUQ A;  2VL7 A;  1K62 A;  3F4R A;  3CRW 1;  2NYF A;  2JAW A;  3R6Y A;  2I7D A;  4MWO A;  1K7W A;  4NLE A;  4IQJ M;  1IW7 D;  1B8F A;  2VD6 A;  4C6G A;  1Z4J A;  3NO9 A;  1TJ7 A;  3U19 A;  1Z4M A;  1KQ7 A;  4C5S A;  1U15 A;  2FUS A;  3RD8 A;  2O7F A;  1GK3 A;  1W27 A;  3U13 A;  1J3U A;  3TV2 A;  2FEN A;  3RRP A;  1C3C A;  2D27 A;  2VSF A;  4C5R A;  2D28 C;  1FUR A; 
#chains in the Genus database with same CATH homology
 1C3U A;  2OHY A;  1HY1 A;  1JSW A;  4NSL A;  1GKJ A;  4BAA A;  1GK2 A;  4C5U A;  4ADM A;  2QGA B;  2O78 A;  2O7E A;  2O7B A;  1DOF A;  1TJV A;  2PTS A;  2O6Y A;  2RJR A;  1TJU A;  5EYT A;  1YFM A;  1GKM A;  3QBP A;  2QVE A;  3OCF A;  1Y2M A;  4ADL A;  1FUO A;  3R6Q A;  4V2R A;  1EB4 A;  4BAB A;  4CQ5 A;  3GZH A;  5D6B A;  2RJS A;  3KDZ A;  1FUP A;  5F91 A;  2PTR A;  2PTQ A;  1T6P A;  4HGV A;  3KDY A;  1YFE A;  3NZ4 A;  4FFX A;  3C8T A;  1Q5N A;  1DCN A;  4APA A;  4FLC A;  5HW2 A;  3OCE A;  2O7D A;  4EFC A;  1VDK A;  2J91 A;  1HY0 A;  3R6V A;  1XWO A;  1TJW A;  2PFM A;  4APB A;  2X75 A;  3BHG A;  1U16 A;  4V2Q A;  2NYN A;  2YII A;  1I0A A;  3CZO A;  4EEI A;  2HVG A;  5EYV A;  3UNV A;  1T6J A;  1AUW A;  5F92 A;  4MX2 A;  1YIS A;  1RE5 A;  2E9F A;  3E04 A;  3GTD A;  1FUQ A;  1K62 A;  2NYF A;  3R6Y A;  1K7W A;  4NLE A;  1B8F A;  2VD6 A;  4C6G A;  3NO9 A;  1TJ7 A;  1KQ7 A;  4C5S A;  1U15 A;  2FUS A;  3RD8 A;  2O7F A;  1GK3 A;  1W27 A;  1J3U A;  3TV2 A;  3RRP A;  1C3C A;  4C5R A;  1FUR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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