4NLEA

Crystal structure of apo adenylosuccinate lyase from mycobacterium smegmatis
Total Genus 171
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
171
sequence length
468
structure length
464
Chain Sequence
TIPNVLANRYASDEMVAIWSPEAKIIAERRLWLAVLRAQAELGVAVPDGVVEDYERVLENVDLESIAARERVRHDVKARIEEFNAHEHVHKGMTSRDLTENVEQLQIRQSLELVFSHGVAVVARLAERAVVYRDLVMAGRSHNVAAQATTLGKRFASAAEETLVALTRLRELIDRYPLRGVKGPMGTAQDMLDLFGGDVGKLADLERRVAEFLGFTEVFTSVGQVYPRSLDHDVLSALVQFGAGPSSMAHTIRLMAGHELVTEGFAPGQVGSSAMPHKMNTRSCERVNGLQVVLRGYASMAAELAGAQWNEGDVFCSVVRRVALPDAFFAIDGQTETFLTVLDEFGAYPAVIQRELDRYLPFLATTRILMAAVRAGVGREAAHEVIKEHAVAVALAMREQGREPDLIDRLAGDPRLPLDKVALEAALEDKQAFTGAAGDQVDGVVAAVGELVSRYPEAAKYTSG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Adenylosuccinate lyase
publication title Structural and kinetic studies on Adenylosuccinate Lyase from Mycobacterium smegmatis and Mycobacterium tuberculosis provide new insights on the catalytic residues of the enzyme
pubmed doi rcsb
source organism Mycobacterium smegmatis
molecule tags Lyase
total genus 171
structure length 464
sequence length 468
chains with identical sequence B
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 2013-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10397 ADSL_C Adenylosuccinate lyase C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4nleA03
1.10.275.60 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase C; Chain B, domain 1 4nleA02
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4nleA01
4EFCA 3RRPA 1TJVA 3R6QA 4BABA 2NYFA 1HY1A 5F92A 1YISA 5EYVA 4ADLA 3NO9A 1GKMA 2PTRA 5F91A 3R6VA 4MX2A 2E9FA 1EB4A 1U16A 3R6YA 4V2QA 3KDZA 2YIIA 1DCNA 4APBA 3UNVA 1DOFA 3C8TA 1I0AA 2PTQA 2O7DA 4HGVA 1B8FA 2O7EA 1W27A 2PFMA 2PTSA 2O7FA 1HY0A 2O78A 2RJSA 4C5SA 1JSWA 4V2RA 4C6GA 1Q5NA 2O6YA 2RJRA 5D6BA 3CZOA 4C5UA 1Y2MA 4BAAA 1TJUA 1XWOA 2HVGA 1T6JA 3RD8A 4C5RA 1KQ7A 1GK2A 1J3UA 1TJWA 1RE5A 1FURA 1K62A 1YFEA 5HW2A 4NLEA 2J91A 3QBPA 1YFMA 2FUSA 3OCEA 1TJ7A 4ADMA 1AUWA 3E04A 1T6PA 1VDKA 4CQ5A 2OHYA 1FUPA 4NSLA 1C3UA 2O7BA 5EYTA 3GTDA 1U15A 3NZ4A 4EEIA 3GZHA 2QVEA 2VD6A 1FUQA 1GKJA 3BHGA 1C3CA 2NYNA 2X75A 4APAA 1FUOA 3OCFA 1GK3A 4FFXA 1K7WA 3TV2A 4FLCA 2QGAB 3KDYA
chains in the Genus database with same CATH superfamily
3CI0K 3U13A 4EFCA 3RRPA 1TJVA 4L6AA 3R6QA 4BABA 1XMCA 2NYFA 3F4RA 1HY1A 5F92A 1YISA 5EYVA 4ADLA 3NO9A 4NFLA 1GKMA 1XL7A 4MUMA 2PTRA 5F91A 2VSFA 3R6VA 4MX2A 2E9FA 1Z4JA 1EB4A 4L57A 1U16A 4E88A 3R6YA 4V2QA 2JAUA 3KDZA 2YIIA 1DCNA 4APBA 2JAOA 3UNVA 2D28C 1XL8A 1DOFA 1T9HA 3C8TA 1Z4PX 1I0AA 3BWVA 2PTQA 2RCNA 2O7DA 4HGVA 1B8FA 1Q92A 2O7EA 4WNLA 1W27A 2PFMA 2PTSA 2O7FA 1HY0A 1XMDA 1Z4LA 2O78A 2RJSA 4C5SA 4IQJM 1Z4KA 1JSWA 4V2RA 4C6GA 1Q5NA 1U0LA 3U19A 5H8WA 2O6YA 2RJRA 3F4TA 4L6CA 5D6BA 3CZOA 4C5UA 1Y2MA 2YV5A 4BAAA 1TJUA 4A15A 1Z4QA 1Q91A 1XWOA 2HVGA 1T6JA 3RD8A 4C5RA 2FENA 1KQ7A 1GK2A 1J3UA 1Z4MA 1TJWA 3CRVA 1RE5A 1FURA 1K62A 2D27A 1YFEA 1IW7D 5HW2A 4NLEA 2J91A 1XLYA 3QBPA 1YFMA 5M0IA 4YIKA 2FUSA 3OCEA 4YIHA 1TJ7A 2VL7A 4ADMA 1AUWA 2JAWA 3E04A 1VDKA 1T6PA 4CQ5A 2OHYA 1FUPA 4NSLA 1C3UA 4MWOA 2JARA 1Z4IA 2O7BA 5EYTA 3GTDA 1U15A 2FELA 3NZ4A 1MH9A 4EEIA 3GZHA 2QVEA 5M0JA 2VD6A 1FUQA 1GKJA 3CRW1 3BHGA 1C3CA 2NYNA 2X75A 4APAA 1FUOA 3OCFA 2I7DA 3F4SA 1GK3A 1K7WA 3TV2A 4FFXA 4FLCA 2QGAB 3KDYA
chains in the Genus database with same CATH topology
4EFCA 3RRPA 1TJVA 3R6QA 4BABA 1XMCA 2NYFA 1HY1A 5F92A 1YISA 5EYVA 4ADLA 3NO9A 1GKMA 1XL7A 2PTRA 5F91A 2VSFA 3R6VA 4MX2A 2E9FA 1EB4A 1U16A 3R6YA 4V2QA 3KDZA 2YIIA 1DCNA 4APBA 3UNVA 1XL8A 1DOFA 3C8TA 1I0AA 2PTQA 2O7DA 4HGVA 1B8FA 2O7EA 1W27A 2PFMA 2PTSA 2O7FA 1HY0A 1XMDA 2O78A 2RJSA 4C5SA 1JSWA 4V2RA 4C6GA 1Q5NA 5H8WA 2O6YA 2RJRA 5D6BA 3CZOA 4C5UA 1Y2MA 4BAAA 4A15A 1TJUA 1XWOA 2HVGA 1T6JA 3RD8A 4C5RA 1KQ7A 1GK2A 1J3UA 1TJWA 3CRVA 1RE5A 1FURA 1K62A 1YFEA 5HW2A 4NLEA 2J91A 3QBPA 1YFMA 2FUSA 3OCEA 1TJ7A 2VL7A 4ADMA 1AUWA 3E04A 1T6PA 1VDKA 4CQ5A 2OHYA 1FUPA 4NSLA 1C3UA 2O7BA 5EYTA 3GTDA 1U15A 3NZ4A 4EEIA 3GZHA 2QVEA 2VD6A 1FUQA 1GKJA 3CRW1 3BHGA 1C3CA 2NYNA 2X75A 4APAA 1FUOA 3OCFA 1GK3A 4FFXA 1K7WA 3TV2A 4FLCA 2QGAB 3KDYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EFC A;  3RRP A;  1TJV A;  3R6Q A;  4BAB A;  2NYF A;  1HY1 A;  5F92 A;  1YIS A;  5EYV A;  4ADL A;  3NO9 A;  1GKM A;  2PTR A;  5F91 A;  3R6V A;  4MX2 A;  2E9F A;  1EB4 A;  1U16 A;  3R6Y A;  4V2Q A;  3KDZ A;  2YII A;  1DCN A;  4APB A;  3UNV A;  1DOF A;  3C8T A;  1I0A A;  2PTQ A;  2O7D A;  4HGV A;  1B8F A;  2O7E A;  1W27 A;  2PFM A;  2PTS A;  2O7F A;  1HY0 A;  2O78 A;  2RJS A;  4C5S A;  1JSW A;  4V2R A;  4C6G A;  1Q5N A;  2O6Y A;  2RJR A;  5D6B A;  3CZO A;  4C5U A;  1Y2M A;  4BAA A;  1TJU A;  1XWO A;  2HVG A;  1T6J A;  3RD8 A;  4C5R A;  1KQ7 A;  1GK2 A;  1J3U A;  1TJW A;  1RE5 A;  1FUR A;  1K62 A;  1YFE A;  5HW2 A;  4NLE A;  2J91 A;  3QBP A;  1YFM A;  2FUS A;  3OCE A;  1TJ7 A;  4ADM A;  1AUW A;  3E04 A;  1T6P A;  1VDK A;  4CQ5 A;  2OHY A;  1FUP A;  4NSL A;  1C3U A;  2O7B A;  5EYT A;  3GTD A;  1U15 A;  3NZ4 A;  4EEI A;  3GZH A;  2QVE A;  2VD6 A;  1FUQ A;  1GKJ A;  3BHG A;  1C3C A;  2NYN A;  2X75 A;  4APA A;  1FUO A;  3OCF A;  1GK3 A;  4FFX A;  1K7W A;  3TV2 A;  4FLC A;  2QGA B;  3KDY A; 
#chains in the Genus database with same CATH topology
 3CI0 K;  3U13 A;  4EFC A;  3RRP A;  1TJV A;  4L6A A;  3R6Q A;  4BAB A;  1XMC A;  2NYF A;  3F4R A;  1HY1 A;  5F92 A;  1YIS A;  5EYV A;  4ADL A;  3NO9 A;  4NFL A;  1GKM A;  1XL7 A;  4MUM A;  2PTR A;  5F91 A;  2VSF A;  3R6V A;  4MX2 A;  2E9F A;  1Z4J A;  1EB4 A;  4L57 A;  1U16 A;  4E88 A;  3R6Y A;  4V2Q A;  2JAU A;  3KDZ A;  2YII A;  1DCN A;  4APB A;  2JAO A;  3UNV A;  2D28 C;  1XL8 A;  1DOF A;  1T9H A;  3C8T A;  1Z4P X;  1I0A A;  3BWV A;  2PTQ A;  2RCN A;  2O7D A;  4HGV A;  1B8F A;  1Q92 A;  2O7E A;  4WNL A;  1W27 A;  2PFM A;  2PTS A;  2O7F A;  1HY0 A;  1XMD A;  1Z4L A;  2O78 A;  2RJS A;  4C5S A;  4IQJ M;  1Z4K A;  1JSW A;  4V2R A;  4C6G A;  1Q5N A;  1U0L A;  3U19 A;  5H8W A;  2O6Y A;  2RJR A;  3F4T A;  4L6C A;  5D6B A;  3CZO A;  4C5U A;  1Y2M A;  2YV5 A;  4BAA A;  1TJU A;  4A15 A;  1Z4Q A;  1Q91 A;  1XWO A;  2HVG A;  1T6J A;  3RD8 A;  4C5R A;  2FEN A;  1KQ7 A;  1GK2 A;  1J3U A;  1Z4M A;  1TJW A;  3CRV A;  1RE5 A;  1FUR A;  1K62 A;  2D27 A;  1YFE A;  1IW7 D;  5HW2 A;  4NLE A;  2J91 A;  1XLY A;  3QBP A;  1YFM A;  5M0I A;  4YIK A;  2FUS A;  3OCE A;  4YIH A;  1TJ7 A;  2VL7 A;  4ADM A;  1AUW A;  2JAW A;  3E04 A;  1VDK A;  1T6P A;  4CQ5 A;  2OHY A;  1FUP A;  4NSL A;  1C3U A;  4MWO A;  2JAR A;  1Z4I A;  2O7B A;  5EYT A;  3GTD A;  1U15 A;  2FEL A;  3NZ4 A;  1MH9 A;  4EEI A;  3GZH A;  2QVE A;  5M0J A;  2VD6 A;  1FUQ A;  1GKJ A;  3CRW 1;  3BHG A;  1C3C A;  2NYN A;  2X75 A;  4APA A;  1FUO A;  3OCF A;  2I7D A;  3F4S A;  1GK3 A;  1K7W A;  3TV2 A;  4FFX A;  4FLC A;  2QGA B;  3KDY A; 
#chains in the Genus database with same CATH homology
 4EFC A;  3RRP A;  1TJV A;  3R6Q A;  4BAB A;  1XMC A;  2NYF A;  1HY1 A;  5F92 A;  1YIS A;  5EYV A;  4ADL A;  3NO9 A;  1GKM A;  1XL7 A;  2PTR A;  5F91 A;  2VSF A;  3R6V A;  4MX2 A;  2E9F A;  1EB4 A;  1U16 A;  3R6Y A;  4V2Q A;  3KDZ A;  2YII A;  1DCN A;  4APB A;  3UNV A;  1XL8 A;  1DOF A;  3C8T A;  1I0A A;  2PTQ A;  2O7D A;  4HGV A;  1B8F A;  2O7E A;  1W27 A;  2PFM A;  2PTS A;  2O7F A;  1HY0 A;  1XMD A;  2O78 A;  2RJS A;  4C5S A;  1JSW A;  4V2R A;  4C6G A;  1Q5N A;  5H8W A;  2O6Y A;  2RJR A;  5D6B A;  3CZO A;  4C5U A;  1Y2M A;  4BAA A;  4A15 A;  1TJU A;  1XWO A;  2HVG A;  1T6J A;  3RD8 A;  4C5R A;  1KQ7 A;  1GK2 A;  1J3U A;  1TJW A;  3CRV A;  1RE5 A;  1FUR A;  1K62 A;  1YFE A;  5HW2 A;  4NLE A;  2J91 A;  3QBP A;  1YFM A;  2FUS A;  3OCE A;  1TJ7 A;  2VL7 A;  4ADM A;  1AUW A;  3E04 A;  1T6P A;  1VDK A;  4CQ5 A;  2OHY A;  1FUP A;  4NSL A;  1C3U A;  2O7B A;  5EYT A;  3GTD A;  1U15 A;  3NZ4 A;  4EEI A;  3GZH A;  2QVE A;  2VD6 A;  1FUQ A;  1GKJ A;  3CRW 1;  3BHG A;  1C3C A;  2NYN A;  2X75 A;  4APA A;  1FUO A;  3OCF A;  1GK3 A;  4FFX A;  1K7W A;  3TV2 A;  4FLC A;  2QGA B;  3KDY A; 
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similar chains in the pdb database (?% sequence similarity)

 
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