4NLEA

Crystal structure of apo adenylosuccinate lyase from mycobacterium smegmatis
Total Genus 171
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
171
sequence length
468
structure length
464
Chain Sequence
TIPNVLANRYASDEMVAIWSPEAKIIAERRLWLAVLRAQAELGVAVPDGVVEDYERVLENVDLESIAARERVRHDVKARIEEFNAHEHVHKGMTSRDLTENVEQLQIRQSLELVFSHGVAVVARLAERAVVYRDLVMAGRSHNVAAQATTLGKRFASAAEETLVALTRLRELIDRYPLRGVKGPMGTAQDMLDLFGGDVGKLADLERRVAEFLGFTEVFTSVGQVYPRSLDHDVLSALVQFGAGPSSMAHTIRLMAGHELVTEGFAPGQVGSSAMPHKMNTRSCERVNGLQVVLRGYASMAAELAGAQWNEGDVFCSVVRRVALPDAFFAIDGQTETFLTVLDEFGAYPAVIQRELDRYLPFLATTRILMAAVRAGVGREAAHEVIKEHAVAVALAMREQGREPDLIDRLAGDPRLPLDKVALEAALEDKQAFTGAAGDQVDGVVAAVGELVSRYPEAAKYTSG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and kinetic studies on Adenylosuccinate Lyase from Mycobacterium smegmatis and Mycobacterium tuberculosis provide new insights on the catalytic residues of the enzyme
pubmed doi rcsb
source organism Mycobacterium smegmatis
molecule tags Lyase
molecule keywords Adenylosuccinate lyase
total genus 171
structure length 464
sequence length 468
chains with identical sequence B
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 2013-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10397 ADSL_C Adenylosuccinate lyase C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4nleA03
1.10.275.60 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase C; Chain B, domain 1 4nleA02
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4nleA01
2O7BA 1K62A 1YFEA 1J3UA 2O7EA 5D6BA 4C6GA 3QBPA 3KDYA 4C5RA 5F91A 1FUPA 2OHYA 3UNVA 3KDZA 3GTDA 1HY1A 2NYFA 2HVGA 2E9FA 2NYNA 2VD6A 1U16A 1VDKA 4APAA 1W27A 1FUOA 1C3CA 1FUQA 1GKMA 1I0AA 4NSLA 3NO9A 4NLEA 3GZHA 3OCEA 2O78A 4BAAA 1K7WA 5EYVA 3R6YA 2O6YA 1DOFA 3RD8A 4EEIA 1U15A 1YISA 2RJRA 4APBA 1T6PA 5HW2A 1TJUA 4FLCA 1GKJA 1C3UA 2QGAB 3R6VA 4C5UA 4V2QA 2PFMA 2O7DA 3C8TA 4ADLA 3CZOA 4C5SA 3R6QA 4MX2A 3NZ4A 1XWOA 3E04A 4ADMA 2RJSA 2QVEA 2PTRA 1TJWA 1HY0A 3RRPA 1Y2MA 5F92A 1T6JA 1GK3A 4V2RA 3TV2A 2J91A 3OCFA 2X75A 1TJVA 1Q5NA 4HGVA 1DCNA 1B8FA 1YFMA 2YIIA 4CQ5A 1FURA 2FUSA 4BABA 1GK2A 1TJ7A 3BHGA 1JSWA 1AUWA 2O7FA 1EB4A 1RE5A 4EFCA 2PTSA 5EYTA 2PTQA 4FFXA 1KQ7A
chains in the Genus database with same CATH superfamily
2O7BA 1K62A 1YFEA 1J3UA 2O7EA 2VSFA 5D6BA 1Z4IA 4C6GA 3QBPA 3KDYA 1XL7A 4YIHA 4C5RA 5F91A 1FUPA 2OHYA 3UNVA 3KDZA 2YV5A 1HY1A 3GTDA 2NYFA 2HVGA 3CI0K 2E9FA 2NYNA 2VD6A 1U16A 1VDKA 4APAA 5M0IA 1W27A 1FUOA 4NFLA 1C3CA 4MWOA 2JAOA 1FUQA 1Q91A 1GKMA 1I0AA 4NSLA 3NO9A 1XL8A 1U0LA 4NLEA 4WNLA 1Z4KA 3F4TA 3GZHA 3OCEA 2O78A 4BAAA 1K7WA 5EYVA 1XMDA 4E88A 3R6YA 2O6YA 1DOFA 3RD8A 4EEIA 1U15A 1YISA 2RJRA 3CRVA 4APBA 1T6PA 2I7DA 5HW2A 1XMCA 2JAUA 3F4SA 1TJUA 4FLCA 4YIKA 4A15A 4MUMA 1GKJA 3BWVA 5M0JA 5H8WA 1C3UA 2QGAB 3R6VA 4C5UA 1Z4QA 4V2QA 2PFMA 2RCNA 2O7DA 4L6CA 3C8TA 2FENA 1MH9A 4ADLA 3CZOA 4C5SA 3R6QA 4MX2A 3NZ4A 1XWOA 3E04A 1Z4PX 4ADMA 3U13A 3U19A 2RJSA 2QVEA 1T9HA 2PTRA 1TJWA 2JAWA 1HY0A 3RRPA 1Y2MA 5F92A 1T6JA 1XLYA 1GK3A 4V2RA 3TV2A 2J91A 3OCFA 2X75A 2D28C 1TJVA 1Q5NA 4HGVA 1DCNA 1B8FA 1YFMA 2VL7A 2YIIA 4FFXA 4CQ5A 1FURA 1Z4LA 2FUSA 2JARA 4BABA 2D27A 1GK2A 4L57A 1TJ7A 3BHGA 3CRW1 4L6AA 1JSWA 1AUWA 2O7FA 3F4RA 1Q92A 1EB4A 1RE5A 4EFCA 2PTSA 2FELA 5EYTA 1Z4MA 2PTQA 1Z4JA 1IW7D 1KQ7A 4IQJM
chains in the Genus database with same CATH topology
2O7BA 1K62A 1YFEA 1J3UA 2O7EA 2VSFA 5D6BA 4C6GA 3QBPA 3KDYA 1XL7A 4C5RA 5F91A 1FUPA 2OHYA 3UNVA 3KDZA 3GTDA 1HY1A 2NYFA 2HVGA 2E9FA 2NYNA 2VD6A 1U16A 1VDKA 4APAA 1W27A 1FUOA 1C3CA 1FUQA 1GKMA 1I0AA 4NSLA 3NO9A 1XL8A 4NLEA 3GZHA 3OCEA 2O78A 4BAAA 1K7WA 5EYVA 1XMDA 3R6YA 2O6YA 1DOFA 3RD8A 4EEIA 1U15A 3CRVA 1YISA 2RJRA 4APBA 1T6PA 5HW2A 1XMCA 1TJUA 4FLCA 4A15A 1GKJA 5H8WA 1C3UA 2QGAB 3R6VA 4C5UA 4V2QA 2PFMA 2O7DA 3C8TA 4ADLA 3CZOA 4C5SA 3R6QA 4MX2A 3NZ4A 1XWOA 3E04A 4ADMA 2RJSA 2QVEA 2PTRA 1TJWA 1HY0A 3RRPA 1Y2MA 1T6JA 5F92A 1GK3A 4V2RA 3TV2A 2J91A 3OCFA 2X75A 1TJVA 1Q5NA 4HGVA 1DCNA 1B8FA 1YFMA 2VL7A 2YIIA 4CQ5A 1FURA 2FUSA 4BABA 1GK2A 1TJ7A 3BHGA 3CRW1 1JSWA 1AUWA 2O7FA 1EB4A 1RE5A 4EFCA 2PTSA 5EYTA 2PTQA 4FFXA 1KQ7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2O7B A;  1K62 A;  1YFE A;  1J3U A;  2O7E A;  5D6B A;  4C6G A;  3QBP A;  3KDY A;  4C5R A;  5F91 A;  1FUP A;  2OHY A;  3UNV A;  3KDZ A;  3GTD A;  1HY1 A;  2NYF A;  2HVG A;  2E9F A;  2NYN A;  2VD6 A;  1U16 A;  1VDK A;  4APA A;  1W27 A;  1FUO A;  1C3C A;  1FUQ A;  1GKM A;  1I0A A;  4NSL A;  3NO9 A;  4NLE A;  3GZH A;  3OCE A;  2O78 A;  4BAA A;  1K7W A;  5EYV A;  3R6Y A;  2O6Y A;  1DOF A;  3RD8 A;  4EEI A;  1U15 A;  1YIS A;  2RJR A;  4APB A;  1T6P A;  5HW2 A;  1TJU A;  4FLC A;  1GKJ A;  1C3U A;  2QGA B;  3R6V A;  4C5U A;  4V2Q A;  2PFM A;  2O7D A;  3C8T A;  4ADL A;  3CZO A;  4C5S A;  3R6Q A;  4MX2 A;  3NZ4 A;  1XWO A;  3E04 A;  4ADM A;  2RJS A;  2QVE A;  2PTR A;  1TJW A;  1HY0 A;  3RRP A;  1Y2M A;  5F92 A;  1T6J A;  1GK3 A;  4V2R A;  3TV2 A;  2J91 A;  3OCF A;  2X75 A;  1TJV A;  1Q5N A;  4HGV A;  1DCN A;  1B8F A;  1YFM A;  2YII A;  4CQ5 A;  1FUR A;  2FUS A;  4BAB A;  1GK2 A;  1TJ7 A;  3BHG A;  1JSW A;  1AUW A;  2O7F A;  1EB4 A;  1RE5 A;  4EFC A;  2PTS A;  5EYT A;  2PTQ A;  4FFX A;  1KQ7 A; 
#chains in the Genus database with same CATH topology
 2O7B A;  1K62 A;  1YFE A;  1J3U A;  2O7E A;  2VSF A;  5D6B A;  1Z4I A;  4C6G A;  3QBP A;  3KDY A;  1XL7 A;  4YIH A;  4C5R A;  5F91 A;  1FUP A;  2OHY A;  3UNV A;  3KDZ A;  2YV5 A;  1HY1 A;  3GTD A;  2NYF A;  2HVG A;  3CI0 K;  2E9F A;  2NYN A;  2VD6 A;  1U16 A;  1VDK A;  4APA A;  5M0I A;  1W27 A;  1FUO A;  4NFL A;  1C3C A;  4MWO A;  2JAO A;  1FUQ A;  1Q91 A;  1GKM A;  1I0A A;  4NSL A;  3NO9 A;  1XL8 A;  1U0L A;  4NLE A;  4WNL A;  1Z4K A;  3F4T A;  3GZH A;  3OCE A;  2O78 A;  4BAA A;  1K7W A;  5EYV A;  1XMD A;  4E88 A;  3R6Y A;  2O6Y A;  1DOF A;  3RD8 A;  4EEI A;  1U15 A;  1YIS A;  2RJR A;  3CRV A;  4APB A;  1T6P A;  2I7D A;  5HW2 A;  1XMC A;  2JAU A;  3F4S A;  1TJU A;  4FLC A;  4YIK A;  4A15 A;  4MUM A;  1GKJ A;  3BWV A;  5M0J A;  5H8W A;  1C3U A;  2QGA B;  3R6V A;  4C5U A;  1Z4Q A;  4V2Q A;  2PFM A;  2RCN A;  2O7D A;  4L6C A;  3C8T A;  2FEN A;  1MH9 A;  4ADL A;  3CZO A;  4C5S A;  3R6Q A;  4MX2 A;  3NZ4 A;  1XWO A;  3E04 A;  1Z4P X;  4ADM A;  3U13 A;  3U19 A;  2RJS A;  2QVE A;  1T9H A;  2PTR A;  1TJW A;  2JAW A;  1HY0 A;  3RRP A;  1Y2M A;  5F92 A;  1T6J A;  1XLY A;  1GK3 A;  4V2R A;  3TV2 A;  2J91 A;  3OCF A;  2X75 A;  2D28 C;  1TJV A;  1Q5N A;  4HGV A;  1DCN A;  1B8F A;  1YFM A;  2VL7 A;  2YII A;  4FFX A;  4CQ5 A;  1FUR A;  1Z4L A;  2FUS A;  2JAR A;  4BAB A;  2D27 A;  1GK2 A;  4L57 A;  1TJ7 A;  3BHG A;  3CRW 1;  4L6A A;  1JSW A;  1AUW A;  2O7F A;  3F4R A;  1Q92 A;  1EB4 A;  1RE5 A;  4EFC A;  2PTS A;  2FEL A;  5EYT A;  1Z4M A;  2PTQ A;  1Z4J A;  1IW7 D;  1KQ7 A;  4IQJ M; 
#chains in the Genus database with same CATH homology
 2O7B A;  1K62 A;  1YFE A;  1J3U A;  2O7E A;  2VSF A;  5D6B A;  4C6G A;  3QBP A;  3KDY A;  1XL7 A;  4C5R A;  5F91 A;  1FUP A;  2OHY A;  3UNV A;  3KDZ A;  3GTD A;  1HY1 A;  2NYF A;  2HVG A;  2E9F A;  2NYN A;  2VD6 A;  1U16 A;  1VDK A;  4APA A;  1W27 A;  1FUO A;  1C3C A;  1FUQ A;  1GKM A;  1I0A A;  4NSL A;  3NO9 A;  1XL8 A;  4NLE A;  3GZH A;  3OCE A;  2O78 A;  4BAA A;  1K7W A;  5EYV A;  1XMD A;  3R6Y A;  2O6Y A;  1DOF A;  3RD8 A;  4EEI A;  1U15 A;  3CRV A;  1YIS A;  2RJR A;  4APB A;  1T6P A;  5HW2 A;  1XMC A;  1TJU A;  4FLC A;  4A15 A;  1GKJ A;  5H8W A;  1C3U A;  2QGA B;  3R6V A;  4C5U A;  4V2Q A;  2PFM A;  2O7D A;  3C8T A;  4ADL A;  3CZO A;  4C5S A;  3R6Q A;  4MX2 A;  3NZ4 A;  1XWO A;  3E04 A;  4ADM A;  2RJS A;  2QVE A;  2PTR A;  1TJW A;  1HY0 A;  3RRP A;  1Y2M A;  1T6J A;  5F92 A;  1GK3 A;  4V2R A;  3TV2 A;  2J91 A;  3OCF A;  2X75 A;  1TJV A;  1Q5N A;  4HGV A;  1DCN A;  1B8F A;  1YFM A;  2VL7 A;  2YII A;  4CQ5 A;  1FUR A;  2FUS A;  4BAB A;  1GK2 A;  1TJ7 A;  3BHG A;  3CRW 1;  1JSW A;  1AUW A;  2O7F A;  1EB4 A;  1RE5 A;  4EFC A;  2PTS A;  5EYT A;  2PTQ A;  4FFX A;  1KQ7 A; 
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similar chains in the pdb database (?% sequence similarity)

 
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