4NLEA

Crystal structure of apo adenylosuccinate lyase from mycobacterium smegmatis
Total Genus 171
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
171
sequence length
468
structure length
464
Chain Sequence
TIPNVLANRYASDEMVAIWSPEAKIIAERRLWLAVLRAQAELGVAVPDGVVEDYERVLENVDLESIAARERVRHDVKARIEEFNAHEHVHKGMTSRDLTENVEQLQIRQSLELVFSHGVAVVARLAERAVVYRDLVMAGRSHNVAAQATTLGKRFASAAEETLVALTRLRELIDRYPLRGVKGPMGTAQDMLDLFGGDVGKLADLERRVAEFLGFTEVFTSVGQVYPRSLDHDVLSALVQFGAGPSSMAHTIRLMAGHELVTEGFAPGQVGSSAMPHKMNTRSCERVNGLQVVLRGYASMAAELAGAQWNEGDVFCSVVRRVALPDAFFAIDGQTETFLTVLDEFGAYPAVIQRELDRYLPFLATTRILMAAVRAGVGREAAHEVIKEHAVAVALAMREQGREPDLIDRLAGDPRLPLDKVALEAALEDKQAFTGAAGDQVDGVVAAVGELVSRYPEAAKYTSG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structural and kinetic studies on Adenylosuccinate Lyase from Mycobacterium smegmatis and Mycobacterium tuberculosis provide new insights on the catalytic residues of the enzyme
pubmed doi rcsb
source organism Mycobacterium smegmatis
molecule tags Lyase
molecule keywords Adenylosuccinate lyase
total genus 171
structure length 464
sequence length 468
chains with identical sequence B
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 2013-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10397 ADSL_C Adenylosuccinate lyase C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4nleA03
1.10.275.60 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase C; Chain B, domain 1 4nleA02
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4nleA01
2O7DA 1JSWA 1I0AA 1GK3A 3UNVA 3NZ4A 1B8FA 2PFMA 5D6BA 1KQ7A 3BHGA 2NYFA 5EYTA 2RJRA 4ADMA 1VDKA 2E9FA 3NO9A 1U15A 4C5UA 1TJ7A 1K62A 3RRPA 2HVGA 2O6YA 1J3UA 4BABA 4FLCA 3GZHA 1TJWA 5HW2A 2O78A 1FURA 3GTDA 3TV2A 4FFXA 3C8TA 1TJUA 1XWOA 3R6QA 1AUWA 1GKJA 4ADLA 4V2RA 5EYVA 2PTSA 1DCNA 1W27A 1K7WA 1YFMA 5F92A 2RJSA 1T6JA 1FUOA 1HY1A 2O7BA 3KDYA 4EEIA 1YFEA 1DOFA 1T6PA 3RD8A 4C6GA 2O7EA 3E04A 2X75A 2VD6A 3R6YA 2PTQA 1EB4A 1YISA 1HY0A 3CZOA 1FUPA 2YIIA 1Y2MA 3R6VA 4BAAA 4APBA 1C3UA 4NSLA 3QBPA 2QVEA 2PTRA 4HGVA 4V2QA 1C3CA 4C5SA 2NYNA 2FUSA 2J91A 1RE5A 2O7FA 1GK2A 2OHYA 4CQ5A 1FUQA 1TJVA 4C5RA 4APAA 4MX2A 3OCFA 5F91A 1U16A 4NLEA 3OCEA 2QGAB 3KDZA 1Q5NA 1GKMA 4EFCA
chains in the Genus database with same CATH superfamily
2O7DA 1JSWA 3CRVA 1I0AA 1GK3A 3UNVA 1Z4QA 3NZ4A 2D27A 1B8FA 3CI0K 2PFMA 5D6BA 3U19A 1Z4KA 2RCNA 1KQ7A 4WNLA 3BHGA 2NYFA 5EYTA 2RJRA 2FENA 4ADMA 1VDKA 1Z4IA 3BWVA 4L6AA 2E9FA 4MUMA 1XL8A 5M0IA 2JAUA 3NO9A 1XL7A 3F4RA 1U15A 4L57A 4C5UA 1TJ7A 1K62A 3RRPA 2HVGA 2O6YA 1J3UA 3CRW1 3F4TA 4BABA 4IQJM 4FLCA 3F4SA 2JAWA 3GZHA 1TJWA 5HW2A 2O78A 1Q92A 1Z4MA 3U13A 3GTDA 1FURA 2D28C 1U0LA 3TV2A 4FFXA 3C8TA 1Z4JA 5H8WA 1TJUA 1XWOA 3R6QA 1AUWA 1GKJA 4ADLA 4V2RA 5EYVA 2PTSA 1DCNA 4L6CA 1W27A 1XMDA 1K7WA 1YFMA 5F92A 1XMCA 1IW7D 2RJSA 1T6JA 1FUOA 1HY1A 2O7BA 3KDYA 4EEIA 1YFEA 1DOFA 4YIKA 3RD8A 1T6PA 4C6GA 2JARA 1T9HA 3E04A 2X75A 2O7EA 2VD6A 3R6YA 2PTQA 1EB4A 4E88A 4YIHA 2VSFA 1YISA 1HY0A 3CZOA 1FUPA 2YIIA 1Y2MA 4A15A 3R6VA 4BAAA 1C3UA 4APBA 4NSLA 3QBPA 2QVEA 2PTRA 2I7DA 4HGVA 4V2QA 1C3CA 4C5SA 1Z4PX 2NYNA 2FUSA 2VL7A 1MH9A 2J91A 1RE5A 4MWOA 4NFLA 1GK2A 2O7FA 2OHYA 2YV5A 4CQ5A 1Q91A 1FUQA 1TJVA 4C5RA 4APAA 1Z4LA 4MX2A 3OCFA 5M0JA 5F91A 1U16A 2JAOA 4NLEA 3OCEA 2FELA 2QGAB 3KDZA 1Q5NA 1XLYA 1GKMA 4EFCA
chains in the Genus database with same CATH topology
2O7DA 1JSWA 3CRVA 1I0AA 1GK3A 3UNVA 3NZ4A 1B8FA 2PFMA 5D6BA 1KQ7A 3BHGA 2NYFA 5EYTA 2RJRA 4ADMA 1VDKA 2E9FA 1XL8A 3NO9A 1XL7A 1U15A 4C5UA 1TJ7A 1K62A 3RRPA 2HVGA 2O6YA 1J3UA 3CRW1 4BABA 4FLCA 3GZHA 1TJWA 5HW2A 2O78A 1FURA 3GTDA 3TV2A 4FFXA 3C8TA 5H8WA 1TJUA 1XWOA 3R6QA 1AUWA 1GKJA 4ADLA 4V2RA 5EYVA 2PTSA 1DCNA 1W27A 1XMDA 1K7WA 1YFMA 5F92A 1XMCA 2RJSA 1T6JA 1FUOA 1HY1A 2O7BA 3KDYA 4EEIA 1YFEA 1DOFA 1T6PA 3RD8A 4C6GA 3E04A 2X75A 2O7EA 2VD6A 3R6YA 2PTQA 1EB4A 2VSFA 1YISA 1HY0A 3CZOA 1FUPA 2YIIA 1Y2MA 4A15A 3R6VA 4BAAA 4APBA 1C3UA 4NSLA 3QBPA 2QVEA 2PTRA 4HGVA 4V2QA 1C3CA 4C5SA 2NYNA 2FUSA 2VL7A 2J91A 1RE5A 2O7FA 1GK2A 2OHYA 4CQ5A 1FUQA 1TJVA 4C5RA 4APAA 4MX2A 3OCFA 5F91A 1U16A 4NLEA 3OCEA 2QGAB 3KDZA 1Q5NA 1GKMA 4EFCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2O7D A;  1JSW A;  1I0A A;  1GK3 A;  3UNV A;  3NZ4 A;  1B8F A;  2PFM A;  5D6B A;  1KQ7 A;  3BHG A;  2NYF A;  5EYT A;  2RJR A;  4ADM A;  1VDK A;  2E9F A;  3NO9 A;  1U15 A;  4C5U A;  1TJ7 A;  1K62 A;  3RRP A;  2HVG A;  2O6Y A;  1J3U A;  4BAB A;  4FLC A;  3GZH A;  1TJW A;  5HW2 A;  2O78 A;  1FUR A;  3GTD A;  3TV2 A;  4FFX A;  3C8T A;  1TJU A;  1XWO A;  3R6Q A;  1AUW A;  1GKJ A;  4ADL A;  4V2R A;  5EYV A;  2PTS A;  1DCN A;  1W27 A;  1K7W A;  1YFM A;  5F92 A;  2RJS A;  1T6J A;  1FUO A;  1HY1 A;  2O7B A;  3KDY A;  4EEI A;  1YFE A;  1DOF A;  1T6P A;  3RD8 A;  4C6G A;  2O7E A;  3E04 A;  2X75 A;  2VD6 A;  3R6Y A;  2PTQ A;  1EB4 A;  1YIS A;  1HY0 A;  3CZO A;  1FUP A;  2YII A;  1Y2M A;  3R6V A;  4BAA A;  4APB A;  1C3U A;  4NSL A;  3QBP A;  2QVE A;  2PTR A;  4HGV A;  4V2Q A;  1C3C A;  4C5S A;  2NYN A;  2FUS A;  2J91 A;  1RE5 A;  2O7F A;  1GK2 A;  2OHY A;  4CQ5 A;  1FUQ A;  1TJV A;  4C5R A;  4APA A;  4MX2 A;  3OCF A;  5F91 A;  1U16 A;  4NLE A;  3OCE A;  2QGA B;  3KDZ A;  1Q5N A;  1GKM A;  4EFC A; 
#chains in the Genus database with same CATH topology
 2O7D A;  1JSW A;  3CRV A;  1I0A A;  1GK3 A;  3UNV A;  1Z4Q A;  3NZ4 A;  2D27 A;  1B8F A;  3CI0 K;  2PFM A;  5D6B A;  3U19 A;  1Z4K A;  2RCN A;  1KQ7 A;  4WNL A;  3BHG A;  2NYF A;  5EYT A;  2RJR A;  2FEN A;  4ADM A;  1VDK A;  1Z4I A;  3BWV A;  4L6A A;  2E9F A;  4MUM A;  1XL8 A;  5M0I A;  2JAU A;  3NO9 A;  1XL7 A;  3F4R A;  1U15 A;  4L57 A;  4C5U A;  1TJ7 A;  1K62 A;  3RRP A;  2HVG A;  2O6Y A;  1J3U A;  3CRW 1;  3F4T A;  4BAB A;  4IQJ M;  4FLC A;  3F4S A;  2JAW A;  3GZH A;  1TJW A;  5HW2 A;  2O78 A;  1Q92 A;  1Z4M A;  3U13 A;  3GTD A;  1FUR A;  2D28 C;  1U0L A;  3TV2 A;  4FFX A;  3C8T A;  1Z4J A;  5H8W A;  1TJU A;  1XWO A;  3R6Q A;  1AUW A;  1GKJ A;  4ADL A;  4V2R A;  5EYV A;  2PTS A;  1DCN A;  4L6C A;  1W27 A;  1XMD A;  1K7W A;  1YFM A;  5F92 A;  1XMC A;  1IW7 D;  2RJS A;  1T6J A;  1FUO A;  1HY1 A;  2O7B A;  3KDY A;  4EEI A;  1YFE A;  1DOF A;  4YIK A;  3RD8 A;  1T6P A;  4C6G A;  2JAR A;  1T9H A;  3E04 A;  2X75 A;  2O7E A;  2VD6 A;  3R6Y A;  2PTQ A;  1EB4 A;  4E88 A;  4YIH A;  2VSF A;  1YIS A;  1HY0 A;  3CZO A;  1FUP A;  2YII A;  1Y2M A;  4A15 A;  3R6V A;  4BAA A;  1C3U A;  4APB A;  4NSL A;  3QBP A;  2QVE A;  2PTR A;  2I7D A;  4HGV A;  4V2Q A;  1C3C A;  4C5S A;  1Z4P X;  2NYN A;  2FUS A;  2VL7 A;  1MH9 A;  2J91 A;  1RE5 A;  4MWO A;  4NFL A;  1GK2 A;  2O7F A;  2OHY A;  2YV5 A;  4CQ5 A;  1Q91 A;  1FUQ A;  1TJV A;  4C5R A;  4APA A;  1Z4L A;  4MX2 A;  3OCF A;  5M0J A;  5F91 A;  1U16 A;  2JAO A;  4NLE A;  3OCE A;  2FEL A;  2QGA B;  3KDZ A;  1Q5N A;  1XLY A;  1GKM A;  4EFC A; 
#chains in the Genus database with same CATH homology
 2O7D A;  1JSW A;  3CRV A;  1I0A A;  1GK3 A;  3UNV A;  3NZ4 A;  1B8F A;  2PFM A;  5D6B A;  1KQ7 A;  3BHG A;  2NYF A;  5EYT A;  2RJR A;  4ADM A;  1VDK A;  2E9F A;  1XL8 A;  3NO9 A;  1XL7 A;  1U15 A;  4C5U A;  1TJ7 A;  1K62 A;  3RRP A;  2HVG A;  2O6Y A;  1J3U A;  3CRW 1;  4BAB A;  4FLC A;  3GZH A;  1TJW A;  5HW2 A;  2O78 A;  1FUR A;  3GTD A;  3TV2 A;  4FFX A;  3C8T A;  5H8W A;  1TJU A;  1XWO A;  3R6Q A;  1AUW A;  1GKJ A;  4ADL A;  4V2R A;  5EYV A;  2PTS A;  1DCN A;  1W27 A;  1XMD A;  1K7W A;  1YFM A;  5F92 A;  1XMC A;  2RJS A;  1T6J A;  1FUO A;  1HY1 A;  2O7B A;  3KDY A;  4EEI A;  1YFE A;  1DOF A;  1T6P A;  3RD8 A;  4C6G A;  3E04 A;  2X75 A;  2O7E A;  2VD6 A;  3R6Y A;  2PTQ A;  1EB4 A;  2VSF A;  1YIS A;  1HY0 A;  3CZO A;  1FUP A;  2YII A;  1Y2M A;  4A15 A;  3R6V A;  4BAA A;  4APB A;  1C3U A;  4NSL A;  3QBP A;  2QVE A;  2PTR A;  4HGV A;  4V2Q A;  1C3C A;  4C5S A;  2NYN A;  2FUS A;  2VL7 A;  2J91 A;  1RE5 A;  2O7F A;  1GK2 A;  2OHY A;  4CQ5 A;  1FUQ A;  1TJV A;  4C5R A;  4APA A;  4MX2 A;  3OCF A;  5F91 A;  1U16 A;  4NLE A;  3OCE A;  2QGA B;  3KDZ A;  1Q5N A;  1GKM A;  4EFC A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...