4NLEA

Crystal structure of apo adenylosuccinate lyase from mycobacterium smegmatis
Total Genus 171
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
171
sequence length
468
structure length
464
Chain Sequence
TIPNVLANRYASDEMVAIWSPEAKIIAERRLWLAVLRAQAELGVAVPDGVVEDYERVLENVDLESIAARERVRHDVKARIEEFNAHEHVHKGMTSRDLTENVEQLQIRQSLELVFSHGVAVVARLAERAVVYRDLVMAGRSHNVAAQATTLGKRFASAAEETLVALTRLRELIDRYPLRGVKGPMGTAQDMLDLFGGDVGKLADLERRVAEFLGFTEVFTSVGQVYPRSLDHDVLSALVQFGAGPSSMAHTIRLMAGHELVTEGFAPGQVGSSAMPHKMNTRSCERVNGLQVVLRGYASMAAELAGAQWNEGDVFCSVVRRVALPDAFFAIDGQTETFLTVLDEFGAYPAVIQRELDRYLPFLATTRILMAAVRAGVGREAAHEVIKEHAVAVALAMREQGREPDLIDRLAGDPRLPLDKVALEAALEDKQAFTGAAGDQVDGVVAAVGELVSRYPEAAKYTSG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lyase
molecule keywords Adenylosuccinate lyase
publication title Structural and kinetic studies on Adenylosuccinate Lyase from Mycobacterium smegmatis and Mycobacterium tuberculosis provide new insights on the catalytic residues of the enzyme
pubmed doi rcsb
source organism Mycobacterium smegmatis
total genus 171
structure length 464
sequence length 468
chains with identical sequence B
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 2013-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10397 ADSL_C Adenylosuccinate lyase C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4nleA03
1.10.275.60 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase C; Chain B, domain 1 4nleA02
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4nleA01
3BHGA 2NYNA 3R6YA 1FUOA 1GKJA 1Q5NA 2QVEA 4BABA 3GZHA 2OHYA 4V2RA 1FUPA 5EYTA 1HY1A 4NLEA 4ADLA 2X75A 1GK2A 4BAAA 3R6QA 2O7DA 1J3UA 4CQ5A 1T6PA 3TV2A 3KDYA 4C6GA 1K7WA 1YISA 3UNVA 2E9FA 3NZ4A 1RE5A 2FUSA 1FURA 4NSLA 3NO9A 4EEIA 1YFMA 3C8TA 2HVGA 2PTQA 2O7FA 1T6JA 3KDZA 2PTRA 4C5UA 2O7EA 4FLCA 5HW2A 1C3CA 5D6BA 4HGVA 3OCEA 4V2QA 1JSWA 2VD6A 1K62A 1TJWA 2RJSA 3RRPA 3QBPA 3E04A 4MX2A 2YIIA 1TJUA 4C5RA 2NYFA 3GTDA 4APBA 1U16A 2O78A 1C3UA 1XWOA 1YFEA 1AUWA 3RD8A 2PFMA 1TJVA 3R6VA 5F92A 1VDKA 5EYVA 2O6YA 1W27A 2RJRA 4EFCA 4C5SA 2QGAB 2PTSA 1GK3A 3CZOA 5F91A 1HY0A 4ADMA 2O7BA 4FFXA 1U15A 1EB4A 1GKMA 4APAA 3OCFA 1TJ7A 1DCNA 1DOFA 1FUQA 1B8FA 2J91A 1KQ7A 1I0AA 1Y2MA
chains in the Genus database with same CATH superfamily
3BHGA 1Z4IA 2D27A 2NYNA 3R6YA 4WNLA 1FUOA 1GKJA 1Q5NA 2QVEA 2D28C 3GZHA 2OHYA 4V2RA 1FUPA 5EYTA 4BABA 2JAOA 1HY1A 4NLEA 4ADLA 1Q92A 1Z4KA 2X75A 1GK2A 4BAAA 3R6QA 1Z4LA 1Z4JA 2O7DA 4L6CA 1J3UA 1XLYA 4CQ5A 1T6PA 2VL7A 3TV2A 3KDYA 4C6GA 1K7WA 1XMDA 1YISA 3UNVA 2YV5A 2E9FA 3NZ4A 2FELA 1RE5A 2FUSA 1FURA 4NSLA 1XL7A 3NO9A 4EEIA 1YFMA 3C8TA 2HVGA 2PTQA 2O7FA 1T6JA 4YIHA 3KDZA 1Z4QA 2PTRA 4MUMA 4C5UA 3CRVA 2O7EA 2FENA 4FLCA 4MWOA 5HW2A 1C3CA 1Z4PX 5D6BA 4NFLA 3CRW1 4HGVA 3OCEA 2JAUA 4V2QA 1JSWA 2VSFA 2VD6A 1K62A 1TJWA 2RJSA 1U0LA 4E88A 3RRPA 3QBPA 3E04A 4IQJM 1XMCA 4MX2A 2YIIA 1TJUA 4C5RA 2NYFA 3GTDA 4APBA 3CI0K 1U16A 5M0JA 2O78A 1C3UA 1XWOA 1YFEA 1AUWA 2RCNA 3RD8A 2PFMA 2JARA 1TJVA 3R6VA 5F92A 3U19A 4YIKA 1XL8A 1VDKA 1Q91A 1MH9A 5EYVA 1IW7D 2O6YA 1W27A 2RJRA 2I7DA 4EFCA 4C5SA 3U13A 2QGAB 2PTSA 3F4RA 1GK3A 3CZOA 1Z4MA 5F91A 5M0IA 1HY0A 4ADMA 2O7BA 4FFXA 4L57A 1U15A 3BWVA 3F4SA 1EB4A 1T9HA 1GKMA 4APAA 3OCFA 1TJ7A 1DCNA 1DOFA 1FUQA 1B8FA 2J91A 4L6AA 1KQ7A 2JAWA 1I0AA 1Y2MA 4A15A 3F4TA 5H8WA
chains in the Genus database with same CATH topology
3BHGA 2NYNA 3R6YA 1FUOA 1GKJA 1Q5NA 2QVEA 4BABA 3GZHA 2OHYA 4V2RA 1FUPA 5EYTA 1HY1A 4NLEA 4ADLA 2X75A 1GK2A 4BAAA 3R6QA 2O7DA 1J3UA 4CQ5A 2VL7A 1T6PA 3TV2A 3KDYA 4C6GA 1K7WA 1XMDA 1YISA 3UNVA 2E9FA 3NZ4A 1RE5A 2FUSA 1FURA 4NSLA 1XL7A 3NO9A 4EEIA 1YFMA 3C8TA 2HVGA 2PTQA 2O7FA 1T6JA 3KDZA 2PTRA 4C5UA 3CRVA 2O7EA 4FLCA 5HW2A 1C3CA 5D6BA 3CRW1 4HGVA 3OCEA 4V2QA 1JSWA 2VSFA 2VD6A 1K62A 1TJWA 2RJSA 3RRPA 3QBPA 3E04A 1XMCA 4MX2A 2YIIA 1TJUA 4C5RA 2NYFA 3GTDA 4APBA 1U16A 2O78A 1C3UA 1XWOA 1YFEA 1AUWA 3RD8A 2PFMA 1TJVA 3R6VA 5F92A 1XL8A 1VDKA 5EYVA 2O6YA 1W27A 2RJRA 4EFCA 4C5SA 2QGAB 2PTSA 1GK3A 3CZOA 5F91A 1HY0A 4ADMA 2O7BA 4FFXA 1U15A 1EB4A 1GKMA 4APAA 3OCFA 1TJ7A 1DCNA 1DOFA 1FUQA 1B8FA 2J91A 1KQ7A 1I0AA 1Y2MA 4A15A 5H8WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BHG A;  2NYN A;  3R6Y A;  1FUO A;  1GKJ A;  1Q5N A;  2QVE A;  4BAB A;  3GZH A;  2OHY A;  4V2R A;  1FUP A;  5EYT A;  1HY1 A;  4NLE A;  4ADL A;  2X75 A;  1GK2 A;  4BAA A;  3R6Q A;  2O7D A;  1J3U A;  4CQ5 A;  1T6P A;  3TV2 A;  3KDY A;  4C6G A;  1K7W A;  1YIS A;  3UNV A;  2E9F A;  3NZ4 A;  1RE5 A;  2FUS A;  1FUR A;  4NSL A;  3NO9 A;  4EEI A;  1YFM A;  3C8T A;  2HVG A;  2PTQ A;  2O7F A;  1T6J A;  3KDZ A;  2PTR A;  4C5U A;  2O7E A;  4FLC A;  5HW2 A;  1C3C A;  5D6B A;  4HGV A;  3OCE A;  4V2Q A;  1JSW A;  2VD6 A;  1K62 A;  1TJW A;  2RJS A;  3RRP A;  3QBP A;  3E04 A;  4MX2 A;  2YII A;  1TJU A;  4C5R A;  2NYF A;  3GTD A;  4APB A;  1U16 A;  2O78 A;  1C3U A;  1XWO A;  1YFE A;  1AUW A;  3RD8 A;  2PFM A;  1TJV A;  3R6V A;  5F92 A;  1VDK A;  5EYV A;  2O6Y A;  1W27 A;  2RJR A;  4EFC A;  4C5S A;  2QGA B;  2PTS A;  1GK3 A;  3CZO A;  5F91 A;  1HY0 A;  4ADM A;  2O7B A;  4FFX A;  1U15 A;  1EB4 A;  1GKM A;  4APA A;  3OCF A;  1TJ7 A;  1DCN A;  1DOF A;  1FUQ A;  1B8F A;  2J91 A;  1KQ7 A;  1I0A A;  1Y2M A; 
#chains in the Genus database with same CATH topology
 3BHG A;  1Z4I A;  2D27 A;  2NYN A;  3R6Y A;  4WNL A;  1FUO A;  1GKJ A;  1Q5N A;  2QVE A;  2D28 C;  3GZH A;  2OHY A;  4V2R A;  1FUP A;  5EYT A;  4BAB A;  2JAO A;  1HY1 A;  4NLE A;  4ADL A;  1Q92 A;  1Z4K A;  2X75 A;  1GK2 A;  4BAA A;  3R6Q A;  1Z4L A;  1Z4J A;  2O7D A;  4L6C A;  1J3U A;  1XLY A;  4CQ5 A;  1T6P A;  2VL7 A;  3TV2 A;  3KDY A;  4C6G A;  1K7W A;  1XMD A;  1YIS A;  3UNV A;  2YV5 A;  2E9F A;  3NZ4 A;  2FEL A;  1RE5 A;  2FUS A;  1FUR A;  4NSL A;  1XL7 A;  3NO9 A;  4EEI A;  1YFM A;  3C8T A;  2HVG A;  2PTQ A;  2O7F A;  1T6J A;  4YIH A;  3KDZ A;  1Z4Q A;  2PTR A;  4MUM A;  4C5U A;  3CRV A;  2O7E A;  2FEN A;  4FLC A;  4MWO A;  5HW2 A;  1C3C A;  1Z4P X;  5D6B A;  4NFL A;  3CRW 1;  4HGV A;  3OCE A;  2JAU A;  4V2Q A;  1JSW A;  2VSF A;  2VD6 A;  1K62 A;  1TJW A;  2RJS A;  1U0L A;  4E88 A;  3RRP A;  3QBP A;  3E04 A;  4IQJ M;  1XMC A;  4MX2 A;  2YII A;  1TJU A;  4C5R A;  2NYF A;  3GTD A;  4APB A;  3CI0 K;  1U16 A;  5M0J A;  2O78 A;  1C3U A;  1XWO A;  1YFE A;  1AUW A;  2RCN A;  3RD8 A;  2PFM A;  2JAR A;  1TJV A;  3R6V A;  5F92 A;  3U19 A;  4YIK A;  1XL8 A;  1VDK A;  1Q91 A;  1MH9 A;  5EYV A;  1IW7 D;  2O6Y A;  1W27 A;  2RJR A;  2I7D A;  4EFC A;  4C5S A;  3U13 A;  2QGA B;  2PTS A;  3F4R A;  1GK3 A;  3CZO A;  1Z4M A;  5F91 A;  5M0I A;  1HY0 A;  4ADM A;  2O7B A;  4FFX A;  4L57 A;  1U15 A;  3BWV A;  3F4S A;  1EB4 A;  1T9H A;  1GKM A;  4APA A;  3OCF A;  1TJ7 A;  1DCN A;  1DOF A;  1FUQ A;  1B8F A;  2J91 A;  4L6A A;  1KQ7 A;  2JAW A;  1I0A A;  1Y2M A;  4A15 A;  3F4T A;  5H8W A; 
#chains in the Genus database with same CATH homology
 3BHG A;  2NYN A;  3R6Y A;  1FUO A;  1GKJ A;  1Q5N A;  2QVE A;  4BAB A;  3GZH A;  2OHY A;  4V2R A;  1FUP A;  5EYT A;  1HY1 A;  4NLE A;  4ADL A;  2X75 A;  1GK2 A;  4BAA A;  3R6Q A;  2O7D A;  1J3U A;  4CQ5 A;  2VL7 A;  1T6P A;  3TV2 A;  3KDY A;  4C6G A;  1K7W A;  1XMD A;  1YIS A;  3UNV A;  2E9F A;  3NZ4 A;  1RE5 A;  2FUS A;  1FUR A;  4NSL A;  1XL7 A;  3NO9 A;  4EEI A;  1YFM A;  3C8T A;  2HVG A;  2PTQ A;  2O7F A;  1T6J A;  3KDZ A;  2PTR A;  4C5U A;  3CRV A;  2O7E A;  4FLC A;  5HW2 A;  1C3C A;  5D6B A;  3CRW 1;  4HGV A;  3OCE A;  4V2Q A;  1JSW A;  2VSF A;  2VD6 A;  1K62 A;  1TJW A;  2RJS A;  3RRP A;  3QBP A;  3E04 A;  1XMC A;  4MX2 A;  2YII A;  1TJU A;  4C5R A;  2NYF A;  3GTD A;  4APB A;  1U16 A;  2O78 A;  1C3U A;  1XWO A;  1YFE A;  1AUW A;  3RD8 A;  2PFM A;  1TJV A;  3R6V A;  5F92 A;  1XL8 A;  1VDK A;  5EYV A;  2O6Y A;  1W27 A;  2RJR A;  4EFC A;  4C5S A;  2QGA B;  2PTS A;  1GK3 A;  3CZO A;  5F91 A;  1HY0 A;  4ADM A;  2O7B A;  4FFX A;  1U15 A;  1EB4 A;  1GKM A;  4APA A;  3OCF A;  1TJ7 A;  1DCN A;  1DOF A;  1FUQ A;  1B8F A;  2J91 A;  1KQ7 A;  1I0A A;  1Y2M A;  4A15 A;  5H8W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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