2X75A

Staphylococcus aureus adenylosuccinate lyase
Total Genus 165
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
165
sequence length
430
structure length
427
Chain Sequence
IERYSREEMSNIWTDQNRYEAWLEVEILACEAWSELGHIPKADVQKIRQNAKVNVERAQEIEQETRHDVVAFTRQVSETLGEERKWVHYGLTSTDVVDTALSFVIKQANDIIEKDLERFIDVLAEKAKNYKYTLMMGRTHGVHAEPTTFGVKMALWYTEMQRNLQRFKQVREEIEVGKMSGAVGTFANIPPEIESYVCKHLGIGTAPVSTQTLQRDRHAYYIATLALIATSLEKFAVEIRNLQKTETREVEEAFAKGQKGSSAMPHKRNPIGSENITGISRVIRGYITTAYENVPLWHERDISHSSAERIMLPDVTIALDYALNRFTNIVDRLTVFEDNMRNNIDKTFGLIFSQRVLLALINKGMVREEAYDKVQPKAMISWETKTPFRELIEQDESITTKEELDECFDPKHHLNQVDTIFERAGLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords ADENYLOSUCCINATE LYASE
publication title Structure of Staphylococcus Aureus Adenylosuccinate Lyase (Purb) and Assessment of its Potential as a Target for Structure-Based Inhibitor Discovery.
pubmed doi rcsb
source organism Staphylococcus aureus
molecule tags Lyase
total genus 165
structure length 427
sequence length 430
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 2010-02-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10397 ADSL_C Adenylosuccinate lyase C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 2x75A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2x75A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2x75A02
1FUQA 4FLCA 4HGVA 5D6BA 1TJVA 1VDKA 3KDZA 4V2RA 1TJWA 4ADMA 2NYNA 1RE5A 5F92A 1EB4A 2O7FA 2QVEA 2O7BA 5EYTA 1K62A 4APBA 1FUPA 2VD6A 3BHGA 1FUOA 3RRPA 1T6PA 3OCEA 4C5SA 1DCNA 1GKJA 2E9FA 2YIIA 1AUWA 1C3UA 4V2QA 3GTDA 3R6QA 2NYFA 1JSWA 4C5UA 3CZOA 4FFXA 1T6JA 2RJSA 1K7WA 1FURA 5HW2A 1U16A 2O6YA 1U15A 4EEIA 2O78A 4NSLA 1I0AA 1TJ7A 3RD8A 2QGAB 1HY1A 1HY0A 1YFEA 3OCFA 3C8TA 2OHYA 1XWOA 2HVGA 2PTQA 2X75A 3TV2A 4C6GA 1W27A 1YISA 1C3CA 2FUSA 1Y2MA 5F91A 1TJUA 2J91A 2PFMA 1GK2A 1GKMA 3NZ4A 1GK3A 3NO9A 1DOFA 1YFMA 4APAA 1J3UA 3KDYA 4BAAA 4CQ5A 2O7EA 4NLEA 3GZHA 4BABA 4ADLA 2RJRA 1Q5NA 1B8FA 3R6VA 2PTSA 2PTRA 3QBPA 4C5RA 1KQ7A 4MX2A 2O7DA 5EYVA 3UNVA 4EFCA 3R6YA 3E04A
chains in the Genus database with same CATH superfamily
1FUQA 4FLCA 4WNLA 3BWVA 4HGVA 5D6BA 1TJVA 1VDKA 3KDZA 4V2RA 3F4TA 4MUMA 4YIKA 1TJWA 4ADMA 2NYNA 1RE5A 5F92A 2JARA 1EB4A 1Z4KA 2O7FA 2QVEA 4A15A 2O7BA 4L6CA 2FENA 5EYTA 2YV5A 1K62A 4APBA 1T9HA 2D28C 1FUPA 1Z4JA 2VD6A 3BHGA 1FUOA 1XL8A 3RRPA 1T6PA 2VL7A 3OCEA 4C5SA 1DCNA 1GKJA 4IQJM 2E9FA 5H8WA 2YIIA 1AUWA 1C3UA 1XL7A 4V2QA 3GTDA 1U0LA 3R6QA 2NYFA 1JSWA 4NFLA 4C5UA 3CZOA 4FFXA 1T6JA 2RJSA 1K7WA 2I7DA 1FURA 5HW2A 1U16A 2O6YA 1U15A 4EEIA 2O78A 2JAWA 4NSLA 4E88A 1I0AA 1TJ7A 3RD8A 2QGAB 1HY1A 1HY0A 1YFEA 3OCFA 3C8TA 2OHYA 1XWOA 1XMCA 2HVGA 4L57A 2JAOA 2PTQA 2X75A 3TV2A 4C6GA 1W27A 1YISA 1C3CA 2FUSA 3F4RA 1Y2MA 5F91A 1TJUA 2J91A 2PFMA 2JAUA 1GK2A 1GKMA 1Q91A 3NZ4A 3U19A 3NO9A 1GK3A 1DOFA 1YFMA 4L6AA 1J3UA 4APAA 1MH9A 3KDYA 4BAAA 4CQ5A 2O7EA 4NLEA 3GZHA 4BABA 4ADLA 2RJRA 2RCNA 1Z4MA 3CI0K 3F4SA 1Q5NA 3R6VA 2D27A 1Z4LA 1B8FA 2PTSA 2PTRA 3QBPA 4YIHA 4C5RA 3CRW1 1KQ7A 1Q92A 1Z4QA 5M0IA 4MWOA 1Z4PX 3U13A 4MX2A 2O7DA 2FELA 5EYVA 1XLYA 1IW7D 2VSFA 1Z4IA 3CRVA 3UNVA 4EFCA 3R6YA 5M0JA 1XMDA 3E04A
chains in the Genus database with same CATH topology
1FUQA 4FLCA 4HGVA 5D6BA 1TJVA 1VDKA 3KDZA 4V2RA 1TJWA 4ADMA 2NYNA 1RE5A 5F92A 1EB4A 2O7FA 2QVEA 2O7BA 5EYTA 1K62A 4APBA 1FUPA 2VD6A 3BHGA 1FUOA 3RRPA 1T6PA 3OCEA 4C5SA 1DCNA 1GKJA 2E9FA 2YIIA 1AUWA 1C3UA 4V2QA 3GTDA 3R6QA 2NYFA 1JSWA 4C5UA 3CZOA 4FFXA 1T6JA 2RJSA 1K7WA 1FURA 5HW2A 1U16A 2O6YA 1U15A 4EEIA 2O78A 4NSLA 1I0AA 1TJ7A 3RD8A 2QGAB 1HY1A 1HY0A 1YFEA 3OCFA 3C8TA 2OHYA 1XWOA 2HVGA 2PTQA 2X75A 3TV2A 4C6GA 1W27A 1YISA 1C3CA 2FUSA 1Y2MA 5F91A 1TJUA 2J91A 2PFMA 1GK2A 1GKMA 3NZ4A 1GK3A 3NO9A 1DOFA 1YFMA 4APAA 1J3UA 3KDYA 4BAAA 4CQ5A 2O7EA 4NLEA 3GZHA 4BABA 4ADLA 2RJRA 1Q5NA 1B8FA 3R6VA 2PTSA 2PTRA 3QBPA 4C5RA 1KQ7A 4MX2A 2O7DA 5EYVA 3UNVA 4EFCA 3R6YA 3E04A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FUQ A;  4FLC A;  4HGV A;  5D6B A;  1TJV A;  1VDK A;  3KDZ A;  4V2R A;  1TJW A;  4ADM A;  2NYN A;  1RE5 A;  5F92 A;  1EB4 A;  2O7F A;  2QVE A;  2O7B A;  5EYT A;  1K62 A;  4APB A;  1FUP A;  2VD6 A;  3BHG A;  1FUO A;  3RRP A;  1T6P A;  3OCE A;  4C5S A;  1DCN A;  1GKJ A;  2E9F A;  2YII A;  1AUW A;  1C3U A;  4V2Q A;  3GTD A;  3R6Q A;  2NYF A;  1JSW A;  4C5U A;  3CZO A;  4FFX A;  1T6J A;  2RJS A;  1K7W A;  1FUR A;  5HW2 A;  1U16 A;  2O6Y A;  1U15 A;  4EEI A;  2O78 A;  4NSL A;  1I0A A;  1TJ7 A;  3RD8 A;  2QGA B;  1HY1 A;  1HY0 A;  1YFE A;  3OCF A;  3C8T A;  2OHY A;  1XWO A;  2HVG A;  2PTQ A;  2X75 A;  3TV2 A;  4C6G A;  1W27 A;  1YIS A;  1C3C A;  2FUS A;  1Y2M A;  5F91 A;  1TJU A;  2J91 A;  2PFM A;  1GK2 A;  1GKM A;  3NZ4 A;  1GK3 A;  3NO9 A;  1DOF A;  1YFM A;  4APA A;  1J3U A;  3KDY A;  4BAA A;  4CQ5 A;  2O7E A;  4NLE A;  3GZH A;  4BAB A;  4ADL A;  2RJR A;  1Q5N A;  1B8F A;  3R6V A;  2PTS A;  2PTR A;  3QBP A;  4C5R A;  1KQ7 A;  4MX2 A;  2O7D A;  5EYV A;  3UNV A;  4EFC A;  3R6Y A;  3E04 A; 
#chains in the Genus database with same CATH topology
 1FUQ A;  4FLC A;  4WNL A;  3BWV A;  4HGV A;  5D6B A;  1TJV A;  1VDK A;  3KDZ A;  4V2R A;  3F4T A;  4MUM A;  4YIK A;  1TJW A;  4ADM A;  2NYN A;  1RE5 A;  5F92 A;  2JAR A;  1EB4 A;  1Z4K A;  2O7F A;  2QVE A;  4A15 A;  2O7B A;  4L6C A;  2FEN A;  5EYT A;  2YV5 A;  1K62 A;  4APB A;  1T9H A;  2D28 C;  1FUP A;  1Z4J A;  2VD6 A;  3BHG A;  1FUO A;  1XL8 A;  3RRP A;  1T6P A;  2VL7 A;  3OCE A;  4C5S A;  1DCN A;  1GKJ A;  4IQJ M;  2E9F A;  5H8W A;  2YII A;  1AUW A;  1C3U A;  1XL7 A;  4V2Q A;  3GTD A;  1U0L A;  3R6Q A;  2NYF A;  1JSW A;  4NFL A;  4C5U A;  3CZO A;  4FFX A;  1T6J A;  2RJS A;  1K7W A;  2I7D A;  1FUR A;  5HW2 A;  1U16 A;  2O6Y A;  1U15 A;  4EEI A;  2O78 A;  2JAW A;  4NSL A;  4E88 A;  1I0A A;  1TJ7 A;  3RD8 A;  2QGA B;  1HY1 A;  1HY0 A;  1YFE A;  3OCF A;  3C8T A;  2OHY A;  1XWO A;  1XMC A;  2HVG A;  4L57 A;  2JAO A;  2PTQ A;  2X75 A;  3TV2 A;  4C6G A;  1W27 A;  1YIS A;  1C3C A;  2FUS A;  3F4R A;  1Y2M A;  5F91 A;  1TJU A;  2J91 A;  2PFM A;  2JAU A;  1GK2 A;  1GKM A;  1Q91 A;  3NZ4 A;  3U19 A;  3NO9 A;  1GK3 A;  1DOF A;  1YFM A;  4L6A A;  1J3U A;  4APA A;  1MH9 A;  3KDY A;  4BAA A;  4CQ5 A;  2O7E A;  4NLE A;  3GZH A;  4BAB A;  4ADL A;  2RJR A;  2RCN A;  1Z4M A;  3CI0 K;  3F4S A;  1Q5N A;  3R6V A;  2D27 A;  1Z4L A;  1B8F A;  2PTS A;  2PTR A;  3QBP A;  4YIH A;  4C5R A;  3CRW 1;  1KQ7 A;  1Q92 A;  1Z4Q A;  5M0I A;  4MWO A;  1Z4P X;  3U13 A;  4MX2 A;  2O7D A;  2FEL A;  5EYV A;  1XLY A;  1IW7 D;  2VSF A;  1Z4I A;  3CRV A;  3UNV A;  4EFC A;  3R6Y A;  5M0J A;  1XMD A;  3E04 A; 
#chains in the Genus database with same CATH homology
 1FUQ A;  4FLC A;  4HGV A;  5D6B A;  1TJV A;  1VDK A;  3KDZ A;  4V2R A;  1TJW A;  4ADM A;  2NYN A;  1RE5 A;  5F92 A;  1EB4 A;  2O7F A;  2QVE A;  2O7B A;  5EYT A;  1K62 A;  4APB A;  1FUP A;  2VD6 A;  3BHG A;  1FUO A;  3RRP A;  1T6P A;  3OCE A;  4C5S A;  1DCN A;  1GKJ A;  2E9F A;  2YII A;  1AUW A;  1C3U A;  4V2Q A;  3GTD A;  3R6Q A;  2NYF A;  1JSW A;  4C5U A;  3CZO A;  4FFX A;  1T6J A;  2RJS A;  1K7W A;  1FUR A;  5HW2 A;  1U16 A;  2O6Y A;  1U15 A;  4EEI A;  2O78 A;  4NSL A;  1I0A A;  1TJ7 A;  3RD8 A;  2QGA B;  1HY1 A;  1HY0 A;  1YFE A;  3OCF A;  3C8T A;  2OHY A;  1XWO A;  2HVG A;  2PTQ A;  2X75 A;  3TV2 A;  4C6G A;  1W27 A;  1YIS A;  1C3C A;  2FUS A;  1Y2M A;  5F91 A;  1TJU A;  2J91 A;  2PFM A;  1GK2 A;  1GKM A;  3NZ4 A;  1GK3 A;  3NO9 A;  1DOF A;  1YFM A;  4APA A;  1J3U A;  3KDY A;  4BAA A;  4CQ5 A;  2O7E A;  4NLE A;  3GZH A;  4BAB A;  4ADL A;  2RJR A;  1Q5N A;  1B8F A;  3R6V A;  2PTS A;  2PTR A;  3QBP A;  4C5R A;  1KQ7 A;  4MX2 A;  2O7D A;  5EYV A;  3UNV A;  4EFC A;  3R6Y A;  3E04 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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