2X75A

Staphylococcus aureus adenylosuccinate lyase
Total Genus 165
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
165
sequence length
430
structure length
427
Chain Sequence
IERYSREEMSNIWTDQNRYEAWLEVEILACEAWSELGHIPKADVQKIRQNAKVNVERAQEIEQETRHDVVAFTRQVSETLGEERKWVHYGLTSTDVVDTALSFVIKQANDIIEKDLERFIDVLAEKAKNYKYTLMMGRTHGVHAEPTTFGVKMALWYTEMQRNLQRFKQVREEIEVGKMSGAVGTFANIPPEIESYVCKHLGIGTAPVSTQTLQRDRHAYYIATLALIATSLEKFAVEIRNLQKTETREVEEAFAKGQKGSSAMPHKRNPIGSENITGISRVIRGYITTAYENVPLWHERDISHSSAERIMLPDVTIALDYALNRFTNIVDRLTVFEDNMRNNIDKTFGLIFSQRVLLALINKGMVREEAYDKVQPKAMISWETKTPFRELIEQDESITTKEELDECFDPKHHLNQVDTIFERAGLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords ADENYLOSUCCINATE LYASE
publication title Structure of Staphylococcus Aureus Adenylosuccinate Lyase (Purb) and Assessment of its Potential as a Target for Structure-Based Inhibitor Discovery.
pubmed doi rcsb
source organism Staphylococcus aureus
molecule tags Lyase
total genus 165
structure length 427
sequence length 430
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 2010-02-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10397 ADSL_C Adenylosuccinate lyase C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 2x75A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2x75A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2x75A02
1YISA 1GK2A 1GKJA 4EEIA 2QGAB 1C3CA 1FURA 3GTDA 3OCEA 2J91A 4APAA 1U15A 3E04A 2VD6A 1TJUA 4BAAA 2QVEA 4V2QA 1T6JA 2YIIA 1HY0A 1C3UA 3R6QA 2RJSA 3C8TA 4NSLA 2E9FA 1DCNA 2FUSA 1AUWA 3RD8A 1RE5A 1TJ7A 4NLEA 1FUQA 2O7DA 4C5SA 3TV2A 2RJRA 3R6YA 3KDZA 2O78A 3CZOA 1FUOA 3NZ4A 2PFMA 1XWOA 3UNVA 4APBA 1Q5NA 1B8FA 3KDYA 1GK3A 3BHGA 1EB4A 3GZHA 5EYTA 4C5RA 4BABA 2PTSA 1HY1A 3NO9A 3OCFA 1GKMA 2O7EA 1Y2MA 4EFCA 1W27A 4FLCA 4C6GA 2HVGA 2X75A 4C5UA 2NYFA 1FUPA 1TJWA 1VDKA 4ADMA 2NYNA 1DOFA 1K62A 1KQ7A 2PTRA 5F91A 2O7FA 5EYVA 1YFEA 4HGVA 5D6BA 3R6VA 4CQ5A 1I0AA 2PTQA 4FFXA 1J3UA 3RRPA 3QBPA 2O7BA 1K7WA 1JSWA 5F92A 2O6YA 4ADLA 4V2RA 1TJVA 1U16A 4MX2A 1YFMA 1T6PA 2OHYA 5HW2A
chains in the Genus database with same CATH superfamily
1YISA 1GK2A 1GKJA 4EEIA 2QGAB 2VL7A 1Z4KA 1C3CA 1FURA 3GTDA 3OCEA 2YV5A 2J91A 4APAA 4A15A 1U15A 3E04A 2VD6A 1TJUA 4BAAA 2FELA 3U13A 2QVEA 4V2QA 1T6JA 2YIIA 1HY0A 1C3UA 3CRVA 5M0IA 3R6QA 2RJSA 3C8TA 4NSLA 2E9FA 1DCNA 2FUSA 2RCNA 1AUWA 3RD8A 1RE5A 2FENA 1TJ7A 4NLEA 1FUQA 2O7DA 3F4TA 3F4SA 1Z4PX 4C5SA 3TV2A 4NFLA 2RJRA 1IW7D 3R6YA 3KDZA 3CI0K 2O78A 3CZOA 2JAWA 1FUOA 1Z4JA 3NZ4A 4IQJM 2PFMA 1XWOA 3UNVA 4APBA 1Q5NA 1XL7A 1B8FA 3KDYA 1T9HA 1GK3A 3BHGA 4MWOA 1XMDA 1Q91A 4YIKA 1EB4A 3GZHA 5EYTA 4C5RA 4BABA 2PTSA 1XMCA 1HY1A 1Q92A 3F4RA 3NO9A 3OCFA 3U19A 1GKMA 1Y2MA 2O7EA 4EFCA 2VSFA 2I7DA 5M0JA 1W27A 4E88A 4FLCA 1Z4LA 4C6GA 2HVGA 2X75A 4L6AA 4C5UA 2NYFA 4L57A 1FUPA 1TJWA 1U0LA 1VDKA 1XLYA 4ADMA 1Z4QA 2NYNA 1DOFA 1K62A 1KQ7A 4YIHA 4MUMA 2PTRA 5F91A 2O7FA 2D27A 1YFEA 5EYVA 4HGVA 5D6BA 3R6VA 4CQ5A 3BWVA 1I0AA 2JAOA 2PTQA 4L6CA 4FFXA 1J3UA 3RRPA 2JAUA 1Z4MA 3QBPA 3CRW1 2O7BA 4WNLA 1K7WA 1JSWA 5F92A 1MH9A 2O6YA 4ADLA 4V2RA 1Z4IA 1TJVA 1U16A 4MX2A 5H8WA 1YFMA 2D28C 1T6PA 2JARA 2OHYA 1XL8A 5HW2A
chains in the Genus database with same CATH topology
1YISA 1GK2A 1GKJA 4EEIA 2QGAB 1C3CA 1FURA 3GTDA 3OCEA 2J91A 4APAA 1U15A 3E04A 2VD6A 1TJUA 4BAAA 2QVEA 4V2QA 1T6JA 2YIIA 1HY0A 1C3UA 3R6QA 2RJSA 3C8TA 4NSLA 2E9FA 1DCNA 2FUSA 1AUWA 3RD8A 1RE5A 1TJ7A 4NLEA 1FUQA 2O7DA 4C5SA 3TV2A 2RJRA 3R6YA 3KDZA 2O78A 3CZOA 1FUOA 3NZ4A 2PFMA 1XWOA 3UNVA 4APBA 1Q5NA 1B8FA 3KDYA 1GK3A 3BHGA 1EB4A 3GZHA 5EYTA 4C5RA 4BABA 2PTSA 1HY1A 3NO9A 3OCFA 1GKMA 2O7EA 1Y2MA 4EFCA 1W27A 4FLCA 4C6GA 2HVGA 2X75A 4C5UA 2NYFA 1FUPA 1TJWA 1VDKA 4ADMA 2NYNA 1DOFA 1K62A 1KQ7A 2PTRA 5F91A 2O7FA 5EYVA 1YFEA 4HGVA 5D6BA 3R6VA 4CQ5A 1I0AA 2PTQA 4FFXA 1J3UA 3RRPA 3QBPA 2O7BA 1K7WA 1JSWA 5F92A 2O6YA 4ADLA 4V2RA 1TJVA 1U16A 4MX2A 1YFMA 1T6PA 2OHYA 5HW2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YIS A;  1GK2 A;  1GKJ A;  4EEI A;  2QGA B;  1C3C A;  1FUR A;  3GTD A;  3OCE A;  2J91 A;  4APA A;  1U15 A;  3E04 A;  2VD6 A;  1TJU A;  4BAA A;  2QVE A;  4V2Q A;  1T6J A;  2YII A;  1HY0 A;  1C3U A;  3R6Q A;  2RJS A;  3C8T A;  4NSL A;  2E9F A;  1DCN A;  2FUS A;  1AUW A;  3RD8 A;  1RE5 A;  1TJ7 A;  4NLE A;  1FUQ A;  2O7D A;  4C5S A;  3TV2 A;  2RJR A;  3R6Y A;  3KDZ A;  2O78 A;  3CZO A;  1FUO A;  3NZ4 A;  2PFM A;  1XWO A;  3UNV A;  4APB A;  1Q5N A;  1B8F A;  3KDY A;  1GK3 A;  3BHG A;  1EB4 A;  3GZH A;  5EYT A;  4C5R A;  4BAB A;  2PTS A;  1HY1 A;  3NO9 A;  3OCF A;  1GKM A;  2O7E A;  1Y2M A;  4EFC A;  1W27 A;  4FLC A;  4C6G A;  2HVG A;  2X75 A;  4C5U A;  2NYF A;  1FUP A;  1TJW A;  1VDK A;  4ADM A;  2NYN A;  1DOF A;  1K62 A;  1KQ7 A;  2PTR A;  5F91 A;  2O7F A;  5EYV A;  1YFE A;  4HGV A;  5D6B A;  3R6V A;  4CQ5 A;  1I0A A;  2PTQ A;  4FFX A;  1J3U A;  3RRP A;  3QBP A;  2O7B A;  1K7W A;  1JSW A;  5F92 A;  2O6Y A;  4ADL A;  4V2R A;  1TJV A;  1U16 A;  4MX2 A;  1YFM A;  1T6P A;  2OHY A;  5HW2 A; 
#chains in the Genus database with same CATH topology
 1YIS A;  1GK2 A;  1GKJ A;  4EEI A;  2QGA B;  2VL7 A;  1Z4K A;  1C3C A;  1FUR A;  3GTD A;  3OCE A;  2YV5 A;  2J91 A;  4APA A;  4A15 A;  1U15 A;  3E04 A;  2VD6 A;  1TJU A;  4BAA A;  2FEL A;  3U13 A;  2QVE A;  4V2Q A;  1T6J A;  2YII A;  1HY0 A;  1C3U A;  3CRV A;  5M0I A;  3R6Q A;  2RJS A;  3C8T A;  4NSL A;  2E9F A;  1DCN A;  2FUS A;  2RCN A;  1AUW A;  3RD8 A;  1RE5 A;  2FEN A;  1TJ7 A;  4NLE A;  1FUQ A;  2O7D A;  3F4T A;  3F4S A;  1Z4P X;  4C5S A;  3TV2 A;  4NFL A;  2RJR A;  1IW7 D;  3R6Y A;  3KDZ A;  3CI0 K;  2O78 A;  3CZO A;  2JAW A;  1FUO A;  1Z4J A;  3NZ4 A;  4IQJ M;  2PFM A;  1XWO A;  3UNV A;  4APB A;  1Q5N A;  1XL7 A;  1B8F A;  3KDY A;  1T9H A;  1GK3 A;  3BHG A;  4MWO A;  1XMD A;  1Q91 A;  4YIK A;  1EB4 A;  3GZH A;  5EYT A;  4C5R A;  4BAB A;  2PTS A;  1XMC A;  1HY1 A;  1Q92 A;  3F4R A;  3NO9 A;  3OCF A;  3U19 A;  1GKM A;  1Y2M A;  2O7E A;  4EFC A;  2VSF A;  2I7D A;  5M0J A;  1W27 A;  4E88 A;  4FLC A;  1Z4L A;  4C6G A;  2HVG A;  2X75 A;  4L6A A;  4C5U A;  2NYF A;  4L57 A;  1FUP A;  1TJW A;  1U0L A;  1VDK A;  1XLY A;  4ADM A;  1Z4Q A;  2NYN A;  1DOF A;  1K62 A;  1KQ7 A;  4YIH A;  4MUM A;  2PTR A;  5F91 A;  2O7F A;  2D27 A;  1YFE A;  5EYV A;  4HGV A;  5D6B A;  3R6V A;  4CQ5 A;  3BWV A;  1I0A A;  2JAO A;  2PTQ A;  4L6C A;  4FFX A;  1J3U A;  3RRP A;  2JAU A;  1Z4M A;  3QBP A;  3CRW 1;  2O7B A;  4WNL A;  1K7W A;  1JSW A;  5F92 A;  1MH9 A;  2O6Y A;  4ADL A;  4V2R A;  1Z4I A;  1TJV A;  1U16 A;  4MX2 A;  5H8W A;  1YFM A;  2D28 C;  1T6P A;  2JAR A;  2OHY A;  1XL8 A;  5HW2 A; 
#chains in the Genus database with same CATH homology
 1YIS A;  1GK2 A;  1GKJ A;  4EEI A;  2QGA B;  1C3C A;  1FUR A;  3GTD A;  3OCE A;  2J91 A;  4APA A;  1U15 A;  3E04 A;  2VD6 A;  1TJU A;  4BAA A;  2QVE A;  4V2Q A;  1T6J A;  2YII A;  1HY0 A;  1C3U A;  3R6Q A;  2RJS A;  3C8T A;  4NSL A;  2E9F A;  1DCN A;  2FUS A;  1AUW A;  3RD8 A;  1RE5 A;  1TJ7 A;  4NLE A;  1FUQ A;  2O7D A;  4C5S A;  3TV2 A;  2RJR A;  3R6Y A;  3KDZ A;  2O78 A;  3CZO A;  1FUO A;  3NZ4 A;  2PFM A;  1XWO A;  3UNV A;  4APB A;  1Q5N A;  1B8F A;  3KDY A;  1GK3 A;  3BHG A;  1EB4 A;  3GZH A;  5EYT A;  4C5R A;  4BAB A;  2PTS A;  1HY1 A;  3NO9 A;  3OCF A;  1GKM A;  2O7E A;  1Y2M A;  4EFC A;  1W27 A;  4FLC A;  4C6G A;  2HVG A;  2X75 A;  4C5U A;  2NYF A;  1FUP A;  1TJW A;  1VDK A;  4ADM A;  2NYN A;  1DOF A;  1K62 A;  1KQ7 A;  2PTR A;  5F91 A;  2O7F A;  5EYV A;  1YFE A;  4HGV A;  5D6B A;  3R6V A;  4CQ5 A;  1I0A A;  2PTQ A;  4FFX A;  1J3U A;  3RRP A;  3QBP A;  2O7B A;  1K7W A;  1JSW A;  5F92 A;  2O6Y A;  4ADL A;  4V2R A;  1TJV A;  1U16 A;  4MX2 A;  1YFM A;  1T6P A;  2OHY A;  5HW2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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