2X75A

Staphylococcus aureus adenylosuccinate lyase
Total Genus 165
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
165
sequence length
430
structure length
427
Chain Sequence
IERYSREEMSNIWTDQNRYEAWLEVEILACEAWSELGHIPKADVQKIRQNAKVNVERAQEIEQETRHDVVAFTRQVSETLGEERKWVHYGLTSTDVVDTALSFVIKQANDIIEKDLERFIDVLAEKAKNYKYTLMMGRTHGVHAEPTTFGVKMALWYTEMQRNLQRFKQVREEIEVGKMSGAVGTFANIPPEIESYVCKHLGIGTAPVSTQTLQRDRHAYYIATLALIATSLEKFAVEIRNLQKTETREVEEAFAKGQKGSSAMPHKRNPIGSENITGISRVIRGYITTAYENVPLWHERDISHSSAERIMLPDVTIALDYALNRFTNIVDRLTVFEDNMRNNIDKTFGLIFSQRVLLALINKGMVREEAYDKVQPKAMISWETKTPFRELIEQDESITTKEELDECFDPKHHLNQVDTIFERAGLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of Staphylococcus Aureus Adenylosuccinate Lyase (Purb) and Assessment of its Potential as a Target for Structure-Based Inhibitor Discovery.
pubmed doi rcsb
source organism Staphylococcus aureus
molecule tags Lyase
molecule keywords ADENYLOSUCCINATE LYASE
total genus 165
structure length 427
sequence length 430
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 2010-02-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10397 ADSL_C Adenylosuccinate lyase C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 2x75A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2x75A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2x75A02
1U15A 4NLEA 4EFCA 1YISA 1C3CA 1FUPA 1W27A 2PTQA 3GZHA 3KDYA 4V2RA 1Y2MA 1FURA 2X75A 3OCFA 1DOFA 2O7DA 4MX2A 2RJRA 2O7BA 2RJSA 1FUOA 4CQ5A 4HGVA 4BABA 1K7WA 2VD6A 1J3UA 2FUSA 1EB4A 1TJUA 1K62A 3TV2A 3BHGA 1B8FA 1XWOA 1FUQA 2HVGA 1GK3A 2O78A 4NSLA 2OHYA 1RE5A 1AUWA 2PFMA 3OCEA 3R6YA 3KDZA 4C5SA 4C6GA 1GK2A 1T6PA 3R6QA 2YIIA 2O7EA 4EEIA 5D6BA 3NZ4A 4ADLA 1VDKA 3RRPA 4V2QA 5EYVA 2E9FA 1KQ7A 3C8TA 2J91A 1U16A 1GKMA 4BAAA 4ADMA 5F91A 1YFMA 1GKJA 1YFEA 4APAA 4C5UA 3R6VA 2QGAB 1TJWA 1TJVA 1Q5NA 1JSWA 3GTDA 1HY1A 1T6JA 1TJ7A 2PTRA 2O6YA 2NYFA 2QVEA 3RD8A 2O7FA 1I0AA 4APBA 4FLCA 1HY0A 3QBPA 4C5RA 3E04A 5F92A 1C3UA 3CZOA 5EYTA 1DCNA 2NYNA 2PTSA 4FFXA 5HW2A 3UNVA 3NO9A
chains in the Genus database with same CATH superfamily
2I7DA 1U15A 4NLEA 1Q92A 4EFCA 1YISA 1C3CA 1FUPA 1W27A 2PTQA 3BWVA 3GZHA 3KDYA 4V2RA 1Y2MA 4MUMA 1FURA 2X75A 3OCFA 2VL7A 1DOFA 2O7DA 4MX2A 2JARA 2RJRA 2VSFA 2O7BA 2RJSA 1XMDA 1FUOA 1Z4MA 4CQ5A 4HGVA 4L57A 4BABA 2JAOA 1K7WA 3F4SA 2VD6A 1J3UA 2FUSA 1XMCA 4YIKA 2D28C 1EB4A 1TJUA 4L6CA 4MWOA 1K62A 3TV2A 5H8WA 2D27A 3BHGA 3U19A 1XWOA 1B8FA 3CI0K 1IW7D 4L6AA 1FUQA 4NFLA 2HVGA 1GK3A 1Z4PX 2O78A 4NSLA 2RCNA 1RE5A 2OHYA 1AUWA 2PFMA 3OCEA 3R6YA 3KDZA 4C5SA 4C6GA 1Z4JA 1GK2A 1T6PA 1Z4LA 3R6QA 2YIIA 2O7EA 4EEIA 2FENA 5D6BA 3NZ4A 4ADLA 1VDKA 3RRPA 4V2QA 5EYVA 1MH9A 2E9FA 1KQ7A 3C8TA 1Z4IA 1Z4KA 4IQJM 1U16A 1GKMA 2J91A 4BAAA 4ADMA 5F91A 1YFMA 2JAUA 1GKJA 1YFEA 2FELA 4APAA 4C5UA 3R6VA 2QGAB 1TJWA 1Q91A 1TJVA 1Q5NA 1JSWA 3GTDA 1HY1A 1T6JA 3CRVA 3F4TA 1TJ7A 2PTRA 1U0LA 1XL8A 2O6YA 4WNLA 1XL7A 4A15A 2NYFA 2QVEA 3RD8A 2O7FA 1I0AA 4APBA 4FLCA 1HY0A 3QBPA 4C5RA 3E04A 5F92A 4YIHA 1XLYA 3F4RA 1C3UA 3CRW1 3CZOA 5EYTA 1DCNA 5M0JA 2NYNA 1T9HA 2JAWA 2PTSA 5M0IA 2YV5A 4FFXA 3U13A 5HW2A 3UNVA 3NO9A 1Z4QA 4E88A
chains in the Genus database with same CATH topology
1U15A 4NLEA 4EFCA 1YISA 1C3CA 1FUPA 1W27A 2PTQA 3GZHA 3KDYA 4V2RA 1Y2MA 1FURA 2X75A 3OCFA 1DOFA 2O7DA 4MX2A 2RJRA 2O7BA 2RJSA 1FUOA 4CQ5A 4HGVA 4BABA 1K7WA 2VD6A 1J3UA 2FUSA 1EB4A 1TJUA 1K62A 3TV2A 3BHGA 1B8FA 1XWOA 1FUQA 2HVGA 1GK3A 2O78A 4NSLA 2OHYA 1RE5A 1AUWA 2PFMA 3OCEA 3R6YA 3KDZA 4C5SA 4C6GA 1GK2A 1T6PA 3R6QA 2YIIA 2O7EA 4EEIA 5D6BA 3NZ4A 4ADLA 1VDKA 3RRPA 4V2QA 5EYVA 2E9FA 1KQ7A 3C8TA 2J91A 1U16A 1GKMA 4BAAA 4ADMA 5F91A 1YFMA 1GKJA 1YFEA 4APAA 4C5UA 3R6VA 2QGAB 1TJWA 1TJVA 1Q5NA 1JSWA 3GTDA 1HY1A 1T6JA 1TJ7A 2PTRA 2O6YA 2NYFA 2QVEA 3RD8A 2O7FA 1I0AA 4APBA 4FLCA 1HY0A 3QBPA 4C5RA 3E04A 5F92A 1C3UA 3CZOA 5EYTA 1DCNA 2NYNA 2PTSA 4FFXA 5HW2A 3UNVA 3NO9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1U15 A;  4NLE A;  4EFC A;  1YIS A;  1C3C A;  1FUP A;  1W27 A;  2PTQ A;  3GZH A;  3KDY A;  4V2R A;  1Y2M A;  1FUR A;  2X75 A;  3OCF A;  1DOF A;  2O7D A;  4MX2 A;  2RJR A;  2O7B A;  2RJS A;  1FUO A;  4CQ5 A;  4HGV A;  4BAB A;  1K7W A;  2VD6 A;  1J3U A;  2FUS A;  1EB4 A;  1TJU A;  1K62 A;  3TV2 A;  3BHG A;  1B8F A;  1XWO A;  1FUQ A;  2HVG A;  1GK3 A;  2O78 A;  4NSL A;  2OHY A;  1RE5 A;  1AUW A;  2PFM A;  3OCE A;  3R6Y A;  3KDZ A;  4C5S A;  4C6G A;  1GK2 A;  1T6P A;  3R6Q A;  2YII A;  2O7E A;  4EEI A;  5D6B A;  3NZ4 A;  4ADL A;  1VDK A;  3RRP A;  4V2Q A;  5EYV A;  2E9F A;  1KQ7 A;  3C8T A;  2J91 A;  1U16 A;  1GKM A;  4BAA A;  4ADM A;  5F91 A;  1YFM A;  1GKJ A;  1YFE A;  4APA A;  4C5U A;  3R6V A;  2QGA B;  1TJW A;  1TJV A;  1Q5N A;  1JSW A;  3GTD A;  1HY1 A;  1T6J A;  1TJ7 A;  2PTR A;  2O6Y A;  2NYF A;  2QVE A;  3RD8 A;  2O7F A;  1I0A A;  4APB A;  4FLC A;  1HY0 A;  3QBP A;  4C5R A;  3E04 A;  5F92 A;  1C3U A;  3CZO A;  5EYT A;  1DCN A;  2NYN A;  2PTS A;  4FFX A;  5HW2 A;  3UNV A;  3NO9 A; 
#chains in the Genus database with same CATH topology
 2I7D A;  1U15 A;  4NLE A;  1Q92 A;  4EFC A;  1YIS A;  1C3C A;  1FUP A;  1W27 A;  2PTQ A;  3BWV A;  3GZH A;  3KDY A;  4V2R A;  1Y2M A;  4MUM A;  1FUR A;  2X75 A;  3OCF A;  2VL7 A;  1DOF A;  2O7D A;  4MX2 A;  2JAR A;  2RJR A;  2VSF A;  2O7B A;  2RJS A;  1XMD A;  1FUO A;  1Z4M A;  4CQ5 A;  4HGV A;  4L57 A;  4BAB A;  2JAO A;  1K7W A;  3F4S A;  2VD6 A;  1J3U A;  2FUS A;  1XMC A;  4YIK A;  2D28 C;  1EB4 A;  1TJU A;  4L6C A;  4MWO A;  1K62 A;  3TV2 A;  5H8W A;  2D27 A;  3BHG A;  3U19 A;  1XWO A;  1B8F A;  3CI0 K;  1IW7 D;  4L6A A;  1FUQ A;  4NFL A;  2HVG A;  1GK3 A;  1Z4P X;  2O78 A;  4NSL A;  2RCN A;  1RE5 A;  2OHY A;  1AUW A;  2PFM A;  3OCE A;  3R6Y A;  3KDZ A;  4C5S A;  4C6G A;  1Z4J A;  1GK2 A;  1T6P A;  1Z4L A;  3R6Q A;  2YII A;  2O7E A;  4EEI A;  2FEN A;  5D6B A;  3NZ4 A;  4ADL A;  1VDK A;  3RRP A;  4V2Q A;  5EYV A;  1MH9 A;  2E9F A;  1KQ7 A;  3C8T A;  1Z4I A;  1Z4K A;  4IQJ M;  1U16 A;  1GKM A;  2J91 A;  4BAA A;  4ADM A;  5F91 A;  1YFM A;  2JAU A;  1GKJ A;  1YFE A;  2FEL A;  4APA A;  4C5U A;  3R6V A;  2QGA B;  1TJW A;  1Q91 A;  1TJV A;  1Q5N A;  1JSW A;  3GTD A;  1HY1 A;  1T6J A;  3CRV A;  3F4T A;  1TJ7 A;  2PTR A;  1U0L A;  1XL8 A;  2O6Y A;  4WNL A;  1XL7 A;  4A15 A;  2NYF A;  2QVE A;  3RD8 A;  2O7F A;  1I0A A;  4APB A;  4FLC A;  1HY0 A;  3QBP A;  4C5R A;  3E04 A;  5F92 A;  4YIH A;  1XLY A;  3F4R A;  1C3U A;  3CRW 1;  3CZO A;  5EYT A;  1DCN A;  5M0J A;  2NYN A;  1T9H A;  2JAW A;  2PTS A;  5M0I A;  2YV5 A;  4FFX A;  3U13 A;  5HW2 A;  3UNV A;  3NO9 A;  1Z4Q A;  4E88 A; 
#chains in the Genus database with same CATH homology
 1U15 A;  4NLE A;  4EFC A;  1YIS A;  1C3C A;  1FUP A;  1W27 A;  2PTQ A;  3GZH A;  3KDY A;  4V2R A;  1Y2M A;  1FUR A;  2X75 A;  3OCF A;  1DOF A;  2O7D A;  4MX2 A;  2RJR A;  2O7B A;  2RJS A;  1FUO A;  4CQ5 A;  4HGV A;  4BAB A;  1K7W A;  2VD6 A;  1J3U A;  2FUS A;  1EB4 A;  1TJU A;  1K62 A;  3TV2 A;  3BHG A;  1B8F A;  1XWO A;  1FUQ A;  2HVG A;  1GK3 A;  2O78 A;  4NSL A;  2OHY A;  1RE5 A;  1AUW A;  2PFM A;  3OCE A;  3R6Y A;  3KDZ A;  4C5S A;  4C6G A;  1GK2 A;  1T6P A;  3R6Q A;  2YII A;  2O7E A;  4EEI A;  5D6B A;  3NZ4 A;  4ADL A;  1VDK A;  3RRP A;  4V2Q A;  5EYV A;  2E9F A;  1KQ7 A;  3C8T A;  2J91 A;  1U16 A;  1GKM A;  4BAA A;  4ADM A;  5F91 A;  1YFM A;  1GKJ A;  1YFE A;  4APA A;  4C5U A;  3R6V A;  2QGA B;  1TJW A;  1TJV A;  1Q5N A;  1JSW A;  3GTD A;  1HY1 A;  1T6J A;  1TJ7 A;  2PTR A;  2O6Y A;  2NYF A;  2QVE A;  3RD8 A;  2O7F A;  1I0A A;  4APB A;  4FLC A;  1HY0 A;  3QBP A;  4C5R A;  3E04 A;  5F92 A;  1C3U A;  3CZO A;  5EYT A;  1DCN A;  2NYN A;  2PTS A;  4FFX A;  5HW2 A;  3UNV A;  3NO9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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