3CZOA

Crystal structure of double mutant phenylalanine ammonia-lyase from anabaena variabilis
Total Genus 189
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
189
sequence length
537
structure length
536
Chain Sequence
b'NVIIGNQKLTINDVARVARNGTLVSLTNNTDILQGIQASCDYINNAVESGEPIYGVTSGFGGMANVAISREQASELQTNLVWFLKTGAGNKLPLADVRAAMLLRANSHMRGASGIRLELIKRMEIFLNAGVTPYVYEFGSIGDLVPLSYITGSLIGLDPSFKVDFNGKEMDAPTALRQLNLSPLTLLPKEGLAMMNGTSVMTGIAANCVYDTQILTAIAMGVHALDIQALNGTNQSFHPFIHNSKPHPGQLWAADQMISLLANSQLVRDELDGKHDYRDHELIQDRYSLRCLPQYLGPIVDGISQIAKQIEIEINSVTDNPLIDVDNQASYHGGNFLGQYVGMGMDHLRYYIGLLAKHLDVQIALLASPEFSNGLPPSLLGNRERKVNMGLKGLQICGNSIMPLLTFYGNSIADRFPTHAEQFNQNINSQGYTSATLARRSVDIFQNYVAIALMFGVQAVDLRTYKKTGHYDARASLSPATERLYSAVRHVVGQKPTSDRPYIWNDNEQGLDEHIARISADIAAGGVIVQAVQDIL'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histidine ammonia-lyase
publication title Structural and biochemical characterization of the therapeutic Anabaena variabilis phenylalanine ammonia lyase.
pubmed doi rcsb
source organism Anabaena variabilis
molecule tags Lyase
total genus 189
structure length 536
sequence length 537
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2008-04-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3czoA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3czoA02
2PTSA 1Q5NA 3GZHA 3R6QA 5HW2A 1K62A 2O7BA 1U15A 1T6PA 1TJUA 3OCFA 4V2RA 5EYVA 2YIIA 1TJ7A 2PTRA 3GTDA 1T6JA 1HY1A 1Y2MA 1C3UA 1GKMA 2PFMA 1EB4A 2O6YA 2RJRA 2O7DA 2VD6A 1FURA 3CZOA 1YISA 2O7FA 4FFXA 2HVGA 1J3UA 4APBA 1FUPA 4C5RA 1GK3A 4NLEA 1YFEA 2O78A 2RJSA 1GK2A 3TV2A 3E04A 2NYFA 2X75A 1XWOA 1U16A 2QVEA 4HGVA 1C3CA 2PTQA 1VDKA 4EEIA 1FUOA 1W27A 1TJWA 3NZ4A 1K7WA 2E9FA 4C5UA 1RE5A 3OCEA 5F91A 4BAAA 4EFCA 3NO9A 3R6VA 1DCNA 2O7EA 1B8FA 4BABA 2J91A 3RRPA 1GKJA 2OHYA 4C6GA 1I0AA 4CQ5A 3C8TA 2NYNA 4C5SA 1HY0A 1KQ7A 4V2QA 2FUSA 4ADMA 1YFMA 1AUWA 4MX2A 4ADLA 2QGAB 3QBPA 4NSLA 5D6BA 3RD8A 3KDYA 3KDZA 1DOFA 3UNVA 1TJVA 5F92A 1JSWA 4APAA 1FUQA 3BHGA 4FLCA 5EYTA 3R6YA
chains in the Genus database with same CATH superfamily
1XMDA 1XLYA 2PTSA 1Q5NA 3GZHA 3R6QA 5HW2A 1K62A 2O7BA 1U15A 1T6PA 1TJUA 3OCFA 4V2RA 5EYVA 2YIIA 1TJ7A 2PTRA 3GTDA 1T6JA 1HY1A 1Y2MA 1C3UA 1GKMA 2PFMA 1EB4A 2O6YA 2RJRA 2VL7A 5H8WA 2O7DA 2VD6A 1FURA 3CZOA 1YISA 2O7FA 4FFXA 2HVGA 1J3UA 4APBA 1FUPA 4C5RA 1GK3A 4NLEA 1YFEA 2O78A 4WNLA 2RJSA 1GK2A 1XMCA 3E04A 3TV2A 2NYFA 5M0IA 2X75A 1XWOA 1XL7A 1U16A 2QVEA 4HGVA 1C3CA 2VSFA 2PTQA 1VDKA 4EEIA 1FUOA 1W27A 1TJWA 3NZ4A 2FENA 1K7WA 2E9FA 4C5UA 1RE5A 3CRVA 3OCEA 5F91A 4BAAA 4EFCA 3NO9A 3R6VA 4A15A 1DCNA 5M0JA 2O7EA 1B8FA 4BABA 2J91A 3RRPA 1GKJA 2OHYA 4C6GA 1I0AA 4CQ5A 3CRW1 3C8TA 2NYNA 4C5SA 1HY0A 1KQ7A 4V2QA 2FUSA 4ADMA 1XL8A 1YFMA 1AUWA 4MX2A 4ADLA 2QGAB 3QBPA 4NSLA 5D6BA 3RD8A 2FELA 3KDYA 3KDZA 1DOFA 3UNVA 1TJVA 5F92A 1JSWA 4APAA 1FUQA 3BHGA 4FLCA 5EYTA 3R6YA
chains in the Genus database with same CATH topology
2PTSA 1Q5NA 3GZHA 3R6QA 5HW2A 1K62A 2O7BA 1U15A 1T6PA 1TJUA 3OCFA 4V2RA 5EYVA 2YIIA 1TJ7A 2PTRA 3GTDA 1T6JA 1HY1A 1Y2MA 1C3UA 1GKMA 2PFMA 1EB4A 2O6YA 2RJRA 2O7DA 2VD6A 1FURA 3CZOA 1YISA 2O7FA 4FFXA 2HVGA 1J3UA 4APBA 1FUPA 4C5RA 1GK3A 4NLEA 1YFEA 2O78A 2RJSA 1GK2A 3TV2A 3E04A 2NYFA 2X75A 1XWOA 1U16A 2QVEA 4HGVA 1C3CA 2PTQA 1VDKA 4EEIA 1FUOA 1W27A 1TJWA 3NZ4A 1K7WA 2E9FA 4C5UA 1RE5A 3OCEA 5F91A 4BAAA 4EFCA 3NO9A 3R6VA 1DCNA 2O7EA 1B8FA 4BABA 2J91A 3RRPA 1GKJA 2OHYA 4C6GA 1I0AA 4CQ5A 3C8TA 2NYNA 4C5SA 1HY0A 1KQ7A 4V2QA 2FUSA 4ADMA 1YFMA 1AUWA 4MX2A 4ADLA 2QGAB 3QBPA 4NSLA 5D6BA 3RD8A 3KDYA 3KDZA 1DOFA 3UNVA 1TJVA 5F92A 1JSWA 4APAA 1FUQA 3BHGA 4FLCA 5EYTA 3R6YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PTS A;  1Q5N A;  3GZH A;  3R6Q A;  5HW2 A;  1K62 A;  2O7B A;  1U15 A;  1T6P A;  1TJU A;  3OCF A;  4V2R A;  5EYV A;  2YII A;  1TJ7 A;  2PTR A;  3GTD A;  1T6J A;  1HY1 A;  1Y2M A;  1C3U A;  1GKM A;  2PFM A;  1EB4 A;  2O6Y A;  2RJR A;  2O7D A;  2VD6 A;  1FUR A;  3CZO A;  1YIS A;  2O7F A;  4FFX A;  2HVG A;  1J3U A;  4APB A;  1FUP A;  4C5R A;  1GK3 A;  4NLE A;  1YFE A;  2O78 A;  2RJS A;  1GK2 A;  3TV2 A;  3E04 A;  2NYF A;  2X75 A;  1XWO A;  1U16 A;  2QVE A;  4HGV A;  1C3C A;  2PTQ A;  1VDK A;  4EEI A;  1FUO A;  1W27 A;  1TJW A;  3NZ4 A;  1K7W A;  2E9F A;  4C5U A;  1RE5 A;  3OCE A;  5F91 A;  4BAA A;  4EFC A;  3NO9 A;  3R6V A;  1DCN A;  2O7E A;  1B8F A;  4BAB A;  2J91 A;  3RRP A;  1GKJ A;  2OHY A;  4C6G A;  1I0A A;  4CQ5 A;  3C8T A;  2NYN A;  4C5S A;  1HY0 A;  1KQ7 A;  4V2Q A;  2FUS A;  4ADM A;  1YFM A;  1AUW A;  4MX2 A;  4ADL A;  2QGA B;  3QBP A;  4NSL A;  5D6B A;  3RD8 A;  3KDY A;  3KDZ A;  1DOF A;  3UNV A;  1TJV A;  5F92 A;  1JSW A;  4APA A;  1FUQ A;  3BHG A;  4FLC A;  5EYT A;  3R6Y A; 
#chains in the Genus database with same CATH topology
 1XMD A;  1XLY A;  2PTS A;  1Q5N A;  3GZH A;  3R6Q A;  5HW2 A;  1K62 A;  2O7B A;  1U15 A;  1T6P A;  1TJU A;  3OCF A;  4V2R A;  5EYV A;  2YII A;  1TJ7 A;  2PTR A;  3GTD A;  1T6J A;  1HY1 A;  1Y2M A;  1C3U A;  1GKM A;  2PFM A;  1EB4 A;  2O6Y A;  2RJR A;  2VL7 A;  5H8W A;  2O7D A;  2VD6 A;  1FUR A;  3CZO A;  1YIS A;  2O7F A;  4FFX A;  2HVG A;  1J3U A;  4APB A;  1FUP A;  4C5R A;  1GK3 A;  4NLE A;  1YFE A;  2O78 A;  4WNL A;  2RJS A;  1GK2 A;  1XMC A;  3E04 A;  3TV2 A;  2NYF A;  5M0I A;  2X75 A;  1XWO A;  1XL7 A;  1U16 A;  2QVE A;  4HGV A;  1C3C A;  2VSF A;  2PTQ A;  1VDK A;  4EEI A;  1FUO A;  1W27 A;  1TJW A;  3NZ4 A;  2FEN A;  1K7W A;  2E9F A;  4C5U A;  1RE5 A;  3CRV A;  3OCE A;  5F91 A;  4BAA A;  4EFC A;  3NO9 A;  3R6V A;  4A15 A;  1DCN A;  5M0J A;  2O7E A;  1B8F A;  4BAB A;  2J91 A;  3RRP A;  1GKJ A;  2OHY A;  4C6G A;  1I0A A;  4CQ5 A;  3CRW 1;  3C8T A;  2NYN A;  4C5S A;  1HY0 A;  1KQ7 A;  4V2Q A;  2FUS A;  4ADM A;  1XL8 A;  1YFM A;  1AUW A;  4MX2 A;  4ADL A;  2QGA B;  3QBP A;  4NSL A;  5D6B A;  3RD8 A;  2FEL A;  3KDY A;  3KDZ A;  1DOF A;  3UNV A;  1TJV A;  5F92 A;  1JSW A;  4APA A;  1FUQ A;  3BHG A;  4FLC A;  5EYT A;  3R6Y A; 
#chains in the Genus database with same CATH homology
 2PTS A;  1Q5N A;  3GZH A;  3R6Q A;  5HW2 A;  1K62 A;  2O7B A;  1U15 A;  1T6P A;  1TJU A;  3OCF A;  4V2R A;  5EYV A;  2YII A;  1TJ7 A;  2PTR A;  3GTD A;  1T6J A;  1HY1 A;  1Y2M A;  1C3U A;  1GKM A;  2PFM A;  1EB4 A;  2O6Y A;  2RJR A;  2O7D A;  2VD6 A;  1FUR A;  3CZO A;  1YIS A;  2O7F A;  4FFX A;  2HVG A;  1J3U A;  4APB A;  1FUP A;  4C5R A;  1GK3 A;  4NLE A;  1YFE A;  2O78 A;  2RJS A;  1GK2 A;  3TV2 A;  3E04 A;  2NYF A;  2X75 A;  1XWO A;  1U16 A;  2QVE A;  4HGV A;  1C3C A;  2PTQ A;  1VDK A;  4EEI A;  1FUO A;  1W27 A;  1TJW A;  3NZ4 A;  1K7W A;  2E9F A;  4C5U A;  1RE5 A;  3OCE A;  5F91 A;  4BAA A;  4EFC A;  3NO9 A;  3R6V A;  1DCN A;  2O7E A;  1B8F A;  4BAB A;  2J91 A;  3RRP A;  1GKJ A;  2OHY A;  4C6G A;  1I0A A;  4CQ5 A;  3C8T A;  2NYN A;  4C5S A;  1HY0 A;  1KQ7 A;  4V2Q A;  2FUS A;  4ADM A;  1YFM A;  1AUW A;  4MX2 A;  4ADL A;  2QGA B;  3QBP A;  4NSL A;  5D6B A;  3RD8 A;  3KDY A;  3KDZ A;  1DOF A;  3UNV A;  1TJV A;  5F92 A;  1JSW A;  4APA A;  1FUQ A;  3BHG A;  4FLC A;  5EYT A;  3R6Y A; 
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