3CZOA

Crystal structure of double mutant phenylalanine ammonia-lyase from anabaena variabilis
Total Genus 189
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
189
sequence length
537
structure length
536
Chain Sequence
NVIIGNQKLTINDVARVARNGTLVSLTNNTDILQGIQASCDYINNAVESGEPIYGVTSGFGGMANVAISREQASELQTNLVWFLKTGAGNKLPLADVRAAMLLRANSHMRGASGIRLELIKRMEIFLNAGVTPYVYEFGSIGDLVPLSYITGSLIGLDPSFKVDFNGKEMDAPTALRQLNLSPLTLLPKEGLAMMNGTSVMTGIAANCVYDTQILTAIAMGVHALDIQALNGTNQSFHPFIHNSKPHPGQLWAADQMISLLANSQLVRDELDGKHDYRDHELIQDRYSLRCLPQYLGPIVDGISQIAKQIEIEINSVTDNPLIDVDNQASYHGGNFLGQYVGMGMDHLRYYIGLLAKHLDVQIALLASPEFSNGLPPSLLGNRERKVNMGLKGLQICGNSIMPLLTFYGNSIADRFPTHAEQFNQNINSQGYTSATLARRSVDIFQNYVAIALMFGVQAVDLRTYKKTGHYDARASLSPATERLYSAVRHVVGQKPTSDRPYIWNDNEQGLDEHIARISADIAAGGVIVQAVQDIL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Lyase
molecule keywords Histidine ammonia-lyase
publication title Structural and biochemical characterization of the therapeutic Anabaena variabilis phenylalanine ammonia lyase.
pubmed doi rcsb
source organism Anabaena variabilis
total genus 189
structure length 536
sequence length 537
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2008-04-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3czoA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3czoA02
1TJVA 5EYTA 2O6YA 2QGAB 2O7EA 1RE5A 2NYNA 2O7BA 3KDYA 2NYFA 1EB4A 1TJUA 4C5SA 1GKMA 4EFCA 3KDZA 4NLEA 3OCFA 1DOFA 1K62A 3R6YA 4CQ5A 2YIIA 3BHGA 5F91A 3RRPA 4V2RA 2RJSA 2PFMA 4BABA 3UNVA 4APAA 1FUQA 2X75A 2OHYA 3QBPA 3R6QA 1Y2MA 3RD8A 1YFEA 4APBA 5HW2A 1I0AA 2HVGA 1HY0A 3E04A 3R6VA 4BAAA 2O78A 2VD6A 1YFMA 1GK2A 1U16A 1TJ7A 1FUOA 2PTQA 1DCNA 1HY1A 4EEIA 4C5RA 2O7DA 2PTSA 2PTRA 3OCEA 1T6JA 1VDKA 1Q5NA 3NZ4A 1T6PA 5F92A 3CZOA 1KQ7A 1K7WA 3TV2A 2FUSA 4ADLA 1YISA 1W27A 1FURA 2J91A 4FLCA 4ADMA 1B8FA 2O7FA 1GKJA 1J3UA 4HGVA 2QVEA 1AUWA 1C3CA 1JSWA 4NSLA 3GZHA 1U15A 2RJRA 4MX2A 4C6GA 1TJWA 4C5UA 3NO9A 3GTDA 1GK3A 1XWOA 5EYVA 4FFXA 4V2QA 2E9FA 5D6BA 1FUPA 3C8TA 1C3UA
chains in the Genus database with same CATH superfamily
1TJVA 5EYTA 2O6YA 2QGAB 1XMCA 2O7EA 1RE5A 2FENA 2NYNA 2O7BA 3KDYA 2NYFA 1EB4A 1TJUA 1XL8A 4C5SA 1GKMA 4EFCA 3KDZA 4NLEA 3OCFA 1DOFA 1K62A 3R6YA 4CQ5A 2YIIA 3BHGA 5F91A 3RRPA 4V2RA 2RJSA 2PFMA 4BABA 3UNVA 4APAA 1FUQA 2VL7A 2X75A 2OHYA 3QBPA 3R6QA 1Y2MA 3RD8A 1YFEA 4A15A 4APBA 1XL7A 5HW2A 1I0AA 5H8WA 2VSFA 3CRW1 2HVGA 1HY0A 3E04A 3R6VA 4BAAA 3CRVA 2O78A 2VD6A 1YFMA 1GK2A 1U16A 1TJ7A 1FUOA 2PTQA 1DCNA 1HY1A 4EEIA 4C5RA 2O7DA 2PTSA 2PTRA 3OCEA 1T6JA 1VDKA 1Q5NA 3NZ4A 1T6PA 5F92A 3CZOA 5M0JA 1KQ7A 1XLYA 1K7WA 3TV2A 2FUSA 4ADLA 1YISA 1W27A 1FURA 2J91A 4FLCA 4ADMA 1B8FA 2O7FA 1GKJA 2FELA 5M0IA 1J3UA 4HGVA 2QVEA 1XMDA 1AUWA 1C3CA 1JSWA 4NSLA 3GZHA 1U15A 2RJRA 4MX2A 4C6GA 1TJWA 4C5UA 3NO9A 3GTDA 1GK3A 1XWOA 5EYVA 4FFXA 4V2QA 2E9FA 5D6BA 1FUPA 4WNLA 3C8TA 1C3UA
chains in the Genus database with same CATH topology
1TJVA 5EYTA 2O6YA 2QGAB 2O7EA 1RE5A 2NYNA 2O7BA 3KDYA 2NYFA 1EB4A 1TJUA 4C5SA 1GKMA 4EFCA 3KDZA 4NLEA 3OCFA 1DOFA 1K62A 3R6YA 4CQ5A 2YIIA 3BHGA 5F91A 3RRPA 4V2RA 2RJSA 2PFMA 4BABA 3UNVA 4APAA 1FUQA 2X75A 2OHYA 3QBPA 3R6QA 1Y2MA 3RD8A 1YFEA 4APBA 5HW2A 1I0AA 2HVGA 1HY0A 3E04A 3R6VA 4BAAA 2O78A 2VD6A 1YFMA 1GK2A 1U16A 1TJ7A 1FUOA 2PTQA 1DCNA 1HY1A 4EEIA 4C5RA 2O7DA 2PTSA 2PTRA 3OCEA 1T6JA 1VDKA 1Q5NA 3NZ4A 1T6PA 5F92A 3CZOA 1KQ7A 1K7WA 3TV2A 2FUSA 4ADLA 1YISA 1W27A 1FURA 2J91A 4FLCA 4ADMA 1B8FA 2O7FA 1GKJA 1J3UA 4HGVA 2QVEA 1AUWA 1C3CA 1JSWA 4NSLA 3GZHA 1U15A 2RJRA 4MX2A 4C6GA 1TJWA 4C5UA 3NO9A 3GTDA 1GK3A 1XWOA 5EYVA 4FFXA 4V2QA 2E9FA 5D6BA 1FUPA 3C8TA 1C3UA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TJV A;  5EYT A;  2O6Y A;  2QGA B;  2O7E A;  1RE5 A;  2NYN A;  2O7B A;  3KDY A;  2NYF A;  1EB4 A;  1TJU A;  4C5S A;  1GKM A;  4EFC A;  3KDZ A;  4NLE A;  3OCF A;  1DOF A;  1K62 A;  3R6Y A;  4CQ5 A;  2YII A;  3BHG A;  5F91 A;  3RRP A;  4V2R A;  2RJS A;  2PFM A;  4BAB A;  3UNV A;  4APA A;  1FUQ A;  2X75 A;  2OHY A;  3QBP A;  3R6Q A;  1Y2M A;  3RD8 A;  1YFE A;  4APB A;  5HW2 A;  1I0A A;  2HVG A;  1HY0 A;  3E04 A;  3R6V A;  4BAA A;  2O78 A;  2VD6 A;  1YFM A;  1GK2 A;  1U16 A;  1TJ7 A;  1FUO A;  2PTQ A;  1DCN A;  1HY1 A;  4EEI A;  4C5R A;  2O7D A;  2PTS A;  2PTR A;  3OCE A;  1T6J A;  1VDK A;  1Q5N A;  3NZ4 A;  1T6P A;  5F92 A;  3CZO A;  1KQ7 A;  1K7W A;  3TV2 A;  2FUS A;  4ADL A;  1YIS A;  1W27 A;  1FUR A;  2J91 A;  4FLC A;  4ADM A;  1B8F A;  2O7F A;  1GKJ A;  1J3U A;  4HGV A;  2QVE A;  1AUW A;  1C3C A;  1JSW A;  4NSL A;  3GZH A;  1U15 A;  2RJR A;  4MX2 A;  4C6G A;  1TJW A;  4C5U A;  3NO9 A;  3GTD A;  1GK3 A;  1XWO A;  5EYV A;  4FFX A;  4V2Q A;  2E9F A;  5D6B A;  1FUP A;  3C8T A;  1C3U A; 
#chains in the Genus database with same CATH topology
 1TJV A;  5EYT A;  2O6Y A;  2QGA B;  1XMC A;  2O7E A;  1RE5 A;  2FEN A;  2NYN A;  2O7B A;  3KDY A;  2NYF A;  1EB4 A;  1TJU A;  1XL8 A;  4C5S A;  1GKM A;  4EFC A;  3KDZ A;  4NLE A;  3OCF A;  1DOF A;  1K62 A;  3R6Y A;  4CQ5 A;  2YII A;  3BHG A;  5F91 A;  3RRP A;  4V2R A;  2RJS A;  2PFM A;  4BAB A;  3UNV A;  4APA A;  1FUQ A;  2VL7 A;  2X75 A;  2OHY A;  3QBP A;  3R6Q A;  1Y2M A;  3RD8 A;  1YFE A;  4A15 A;  4APB A;  1XL7 A;  5HW2 A;  1I0A A;  5H8W A;  2VSF A;  3CRW 1;  2HVG A;  1HY0 A;  3E04 A;  3R6V A;  4BAA A;  3CRV A;  2O78 A;  2VD6 A;  1YFM A;  1GK2 A;  1U16 A;  1TJ7 A;  1FUO A;  2PTQ A;  1DCN A;  1HY1 A;  4EEI A;  4C5R A;  2O7D A;  2PTS A;  2PTR A;  3OCE A;  1T6J A;  1VDK A;  1Q5N A;  3NZ4 A;  1T6P A;  5F92 A;  3CZO A;  5M0J A;  1KQ7 A;  1XLY A;  1K7W A;  3TV2 A;  2FUS A;  4ADL A;  1YIS A;  1W27 A;  1FUR A;  2J91 A;  4FLC A;  4ADM A;  1B8F A;  2O7F A;  1GKJ A;  2FEL A;  5M0I A;  1J3U A;  4HGV A;  2QVE A;  1XMD A;  1AUW A;  1C3C A;  1JSW A;  4NSL A;  3GZH A;  1U15 A;  2RJR A;  4MX2 A;  4C6G A;  1TJW A;  4C5U A;  3NO9 A;  3GTD A;  1GK3 A;  1XWO A;  5EYV A;  4FFX A;  4V2Q A;  2E9F A;  5D6B A;  1FUP A;  4WNL A;  3C8T A;  1C3U A; 
#chains in the Genus database with same CATH homology
 1TJV A;  5EYT A;  2O6Y A;  2QGA B;  2O7E A;  1RE5 A;  2NYN A;  2O7B A;  3KDY A;  2NYF A;  1EB4 A;  1TJU A;  4C5S A;  1GKM A;  4EFC A;  3KDZ A;  4NLE A;  3OCF A;  1DOF A;  1K62 A;  3R6Y A;  4CQ5 A;  2YII A;  3BHG A;  5F91 A;  3RRP A;  4V2R A;  2RJS A;  2PFM A;  4BAB A;  3UNV A;  4APA A;  1FUQ A;  2X75 A;  2OHY A;  3QBP A;  3R6Q A;  1Y2M A;  3RD8 A;  1YFE A;  4APB A;  5HW2 A;  1I0A A;  2HVG A;  1HY0 A;  3E04 A;  3R6V A;  4BAA A;  2O78 A;  2VD6 A;  1YFM A;  1GK2 A;  1U16 A;  1TJ7 A;  1FUO A;  2PTQ A;  1DCN A;  1HY1 A;  4EEI A;  4C5R A;  2O7D A;  2PTS A;  2PTR A;  3OCE A;  1T6J A;  1VDK A;  1Q5N A;  3NZ4 A;  1T6P A;  5F92 A;  3CZO A;  1KQ7 A;  1K7W A;  3TV2 A;  2FUS A;  4ADL A;  1YIS A;  1W27 A;  1FUR A;  2J91 A;  4FLC A;  4ADM A;  1B8F A;  2O7F A;  1GKJ A;  1J3U A;  4HGV A;  2QVE A;  1AUW A;  1C3C A;  1JSW A;  4NSL A;  3GZH A;  1U15 A;  2RJR A;  4MX2 A;  4C6G A;  1TJW A;  4C5U A;  3NO9 A;  3GTD A;  1GK3 A;  1XWO A;  5EYV A;  4FFX A;  4V2Q A;  2E9F A;  5D6B A;  1FUP A;  3C8T A;  1C3U A; 
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similar chains in the Genus database (?% sequence similarity)
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