5D6BA

Human fumarase (wild type)
Total Genus 173
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
173
sequence length
462
structure length
462
Chain Sequence
SFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAIMKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Fumarate hydratase, mitochondrial
publication title Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of recombinant human fumarase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Lyase
total genus 173
structure length 462
sequence length 462
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2015-08-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 5d6bA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 5d6bA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 5d6bA02
1FUPA 4FLCA 2PFMA 4BAAA 1HY0A 1RE5A 2O7DA 4APBA 3NO9A 1GK3A 4C5RA 4EEIA 4HGVA 4C5UA 1GKJA 4MX2A 1FUOA 2PTQA 1W27A 2RJSA 3OCFA 4BABA 1AUWA 1J3UA 1DOFA 2J91A 3E04A 3R6VA 5F91A 1FURA 3RD8A 2O7BA 4NLEA 1DCNA 3C8TA 3TV2A 1TJWA 3R6QA 3OCEA 1XWOA 1TJ7A 2HVGA 5HW2A 1Q5NA 4ADMA 1YFMA 3RRPA 2PTRA 1B8FA 1FUQA 2NYFA 1VDKA 3CZOA 1EB4A 2VD6A 4EFCA 1C3CA 1T6JA 2YIIA 3KDZA 4NSLA 3KDYA 3GZHA 1KQ7A 2QGAB 1U16A 1I0AA 2O78A 4C5SA 2O6YA 4C6GA 2RJRA 1GK2A 3NZ4A 5EYTA 4ADLA 1GKMA 3GTDA 3UNVA 2O7FA 2E9FA 3QBPA 1C3UA 1U15A 4FFXA 3BHGA 4CQ5A 1HY1A 1T6PA 1Y2MA 1K62A 1TJUA 4V2RA 1YISA 4APAA 2NYNA 1JSWA 3R6YA 2QVEA 5EYVA 1K7WA 2X75A 5D6BA 2OHYA 1TJVA 4V2QA 2FUSA 5F92A 2O7EA 2PTSA 1YFEA
chains in the Genus database with same CATH superfamily
1Q92A 2D28C 1FUPA 4FLCA 2PFMA 4BAAA 1HY0A 1RE5A 2JAOA 2O7DA 4APBA 3NO9A 1GK3A 4C5RA 4EEIA 3U13A 4HGVA 4C5UA 1Z4JA 2D27A 4E88A 1GKJA 5M0JA 4MX2A 1FUOA 2PTQA 1W27A 2JAUA 2FENA 2RJSA 4L57A 3OCFA 5M0IA 4YIKA 4BABA 1AUWA 1J3UA 1DOFA 1XL8A 2J91A 3E04A 3R6VA 1IW7D 5F91A 1FURA 1Z4IA 3RD8A 2O7BA 4NLEA 3F4TA 3CRW1 1DCNA 1XMCA 2RCNA 4MWOA 2FELA 3C8TA 4MUMA 3F4RA 1Z4LA 3TV2A 1TJWA 3R6QA 3F4SA 3OCEA 1XWOA 3CI0K 1TJ7A 4L6CA 1MH9A 5H8WA 2HVGA 1Q91A 2YV5A 5HW2A 1Q5NA 4ADMA 1YFMA 4NFLA 3RRPA 2PTRA 3BWVA 1FUQA 1B8FA 2NYFA 1VDKA 3CZOA 1EB4A 2VD6A 4A15A 4EFCA 1C3CA 3CRVA 1T6JA 2YIIA 3KDZA 4NSLA 3KDYA 3GZHA 1KQ7A 1U0LA 2QGAB 1U16A 3U19A 1I0AA 2O78A 1XL7A 4C5SA 2O6YA 4C6GA 4WNLA 2RJRA 4L6AA 1GK2A 3NZ4A 5EYTA 2JAWA 4ADLA 1Z4KA 3GTDA 1GKMA 3UNVA 2JARA 1XMDA 2O7FA 2E9FA 3QBPA 1C3UA 1U15A 4FFXA 3BHGA 2VSFA 4CQ5A 1HY1A 2I7DA 1T6PA 1Y2MA 1K62A 1TJUA 4V2RA 1YISA 1T9HA 4APAA 2NYNA 4YIHA 1Z4QA 1JSWA 2VL7A 4IQJM 2QVEA 5EYVA 3R6YA 1K7WA 1Z4PX 2X75A 5D6BA 2OHYA 1XLYA 1Z4MA 1TJVA 4V2QA 2FUSA 5F92A 2O7EA 2PTSA 1YFEA
chains in the Genus database with same CATH topology
1FUPA 4FLCA 2PFMA 4BAAA 1HY0A 1RE5A 2O7DA 4APBA 3NO9A 1GK3A 4C5RA 4EEIA 4HGVA 4C5UA 1GKJA 4MX2A 1FUOA 2PTQA 1W27A 2RJSA 3OCFA 4BABA 1AUWA 1J3UA 1DOFA 2J91A 3E04A 3R6VA 5F91A 1FURA 3RD8A 2O7BA 4NLEA 1DCNA 3C8TA 3TV2A 1TJWA 3R6QA 3OCEA 1XWOA 1TJ7A 2HVGA 5HW2A 1Q5NA 4ADMA 1YFMA 3RRPA 2PTRA 1B8FA 1FUQA 2NYFA 1VDKA 3CZOA 1EB4A 2VD6A 4EFCA 1C3CA 1T6JA 2YIIA 3KDZA 4NSLA 3KDYA 3GZHA 1KQ7A 2QGAB 1U16A 1I0AA 2O78A 4C5SA 2O6YA 4C6GA 2RJRA 1GK2A 3NZ4A 5EYTA 4ADLA 1GKMA 3GTDA 3UNVA 2O7FA 2E9FA 3QBPA 1C3UA 1U15A 4FFXA 3BHGA 4CQ5A 1HY1A 1T6PA 1Y2MA 1K62A 1TJUA 4V2RA 1YISA 4APAA 2NYNA 1JSWA 3R6YA 2QVEA 5EYVA 1K7WA 2X75A 5D6BA 2OHYA 1TJVA 4V2QA 2FUSA 5F92A 2O7EA 2PTSA 1YFEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FUP A;  4FLC A;  2PFM A;  4BAA A;  1HY0 A;  1RE5 A;  2O7D A;  4APB A;  3NO9 A;  1GK3 A;  4C5R A;  4EEI A;  4HGV A;  4C5U A;  1GKJ A;  4MX2 A;  1FUO A;  2PTQ A;  1W27 A;  2RJS A;  3OCF A;  4BAB A;  1AUW A;  1J3U A;  1DOF A;  2J91 A;  3E04 A;  3R6V A;  5F91 A;  1FUR A;  3RD8 A;  2O7B A;  4NLE A;  1DCN A;  3C8T A;  3TV2 A;  1TJW A;  3R6Q A;  3OCE A;  1XWO A;  1TJ7 A;  2HVG A;  5HW2 A;  1Q5N A;  4ADM A;  1YFM A;  3RRP A;  2PTR A;  1B8F A;  1FUQ A;  2NYF A;  1VDK A;  3CZO A;  1EB4 A;  2VD6 A;  4EFC A;  1C3C A;  1T6J A;  2YII A;  3KDZ A;  4NSL A;  3KDY A;  3GZH A;  1KQ7 A;  2QGA B;  1U16 A;  1I0A A;  2O78 A;  4C5S A;  2O6Y A;  4C6G A;  2RJR A;  1GK2 A;  3NZ4 A;  5EYT A;  4ADL A;  1GKM A;  3GTD A;  3UNV A;  2O7F A;  2E9F A;  3QBP A;  1C3U A;  1U15 A;  4FFX A;  3BHG A;  4CQ5 A;  1HY1 A;  1T6P A;  1Y2M A;  1K62 A;  1TJU A;  4V2R A;  1YIS A;  4APA A;  2NYN A;  1JSW A;  3R6Y A;  2QVE A;  5EYV A;  1K7W A;  2X75 A;  5D6B A;  2OHY A;  1TJV A;  4V2Q A;  2FUS A;  5F92 A;  2O7E A;  2PTS A;  1YFE A; 
#chains in the Genus database with same CATH topology
 1Q92 A;  2D28 C;  1FUP A;  4FLC A;  2PFM A;  4BAA A;  1HY0 A;  1RE5 A;  2JAO A;  2O7D A;  4APB A;  3NO9 A;  1GK3 A;  4C5R A;  4EEI A;  3U13 A;  4HGV A;  4C5U A;  1Z4J A;  2D27 A;  4E88 A;  1GKJ A;  5M0J A;  4MX2 A;  1FUO A;  2PTQ A;  1W27 A;  2JAU A;  2FEN A;  2RJS A;  4L57 A;  3OCF A;  5M0I A;  4YIK A;  4BAB A;  1AUW A;  1J3U A;  1DOF A;  1XL8 A;  2J91 A;  3E04 A;  3R6V A;  1IW7 D;  5F91 A;  1FUR A;  1Z4I A;  3RD8 A;  2O7B A;  4NLE A;  3F4T A;  3CRW 1;  1DCN A;  1XMC A;  2RCN A;  4MWO A;  2FEL A;  3C8T A;  4MUM A;  3F4R A;  1Z4L A;  3TV2 A;  1TJW A;  3R6Q A;  3F4S A;  3OCE A;  1XWO A;  3CI0 K;  1TJ7 A;  4L6C A;  1MH9 A;  5H8W A;  2HVG A;  1Q91 A;  2YV5 A;  5HW2 A;  1Q5N A;  4ADM A;  1YFM A;  4NFL A;  3RRP A;  2PTR A;  3BWV A;  1FUQ A;  1B8F A;  2NYF A;  1VDK A;  3CZO A;  1EB4 A;  2VD6 A;  4A15 A;  4EFC A;  1C3C A;  3CRV A;  1T6J A;  2YII A;  3KDZ A;  4NSL A;  3KDY A;  3GZH A;  1KQ7 A;  1U0L A;  2QGA B;  1U16 A;  3U19 A;  1I0A A;  2O78 A;  1XL7 A;  4C5S A;  2O6Y A;  4C6G A;  4WNL A;  2RJR A;  4L6A A;  1GK2 A;  3NZ4 A;  5EYT A;  2JAW A;  4ADL A;  1Z4K A;  3GTD A;  1GKM A;  3UNV A;  2JAR A;  1XMD A;  2O7F A;  2E9F A;  3QBP A;  1C3U A;  1U15 A;  4FFX A;  3BHG A;  2VSF A;  4CQ5 A;  1HY1 A;  2I7D A;  1T6P A;  1Y2M A;  1K62 A;  1TJU A;  4V2R A;  1YIS A;  1T9H A;  4APA A;  2NYN A;  4YIH A;  1Z4Q A;  1JSW A;  2VL7 A;  4IQJ M;  2QVE A;  5EYV A;  3R6Y A;  1K7W A;  1Z4P X;  2X75 A;  5D6B A;  2OHY A;  1XLY A;  1Z4M A;  1TJV A;  4V2Q A;  2FUS A;  5F92 A;  2O7E A;  2PTS A;  1YFE A; 
#chains in the Genus database with same CATH homology
 1FUP A;  4FLC A;  2PFM A;  4BAA A;  1HY0 A;  1RE5 A;  2O7D A;  4APB A;  3NO9 A;  1GK3 A;  4C5R A;  4EEI A;  4HGV A;  4C5U A;  1GKJ A;  4MX2 A;  1FUO A;  2PTQ A;  1W27 A;  2RJS A;  3OCF A;  4BAB A;  1AUW A;  1J3U A;  1DOF A;  2J91 A;  3E04 A;  3R6V A;  5F91 A;  1FUR A;  3RD8 A;  2O7B A;  4NLE A;  1DCN A;  3C8T A;  3TV2 A;  1TJW A;  3R6Q A;  3OCE A;  1XWO A;  1TJ7 A;  2HVG A;  5HW2 A;  1Q5N A;  4ADM A;  1YFM A;  3RRP A;  2PTR A;  1B8F A;  1FUQ A;  2NYF A;  1VDK A;  3CZO A;  1EB4 A;  2VD6 A;  4EFC A;  1C3C A;  1T6J A;  2YII A;  3KDZ A;  4NSL A;  3KDY A;  3GZH A;  1KQ7 A;  2QGA B;  1U16 A;  1I0A A;  2O78 A;  4C5S A;  2O6Y A;  4C6G A;  2RJR A;  1GK2 A;  3NZ4 A;  5EYT A;  4ADL A;  1GKM A;  3GTD A;  3UNV A;  2O7F A;  2E9F A;  3QBP A;  1C3U A;  1U15 A;  4FFX A;  3BHG A;  4CQ5 A;  1HY1 A;  1T6P A;  1Y2M A;  1K62 A;  1TJU A;  4V2R A;  1YIS A;  4APA A;  2NYN A;  1JSW A;  3R6Y A;  2QVE A;  5EYV A;  1K7W A;  2X75 A;  5D6B A;  2OHY A;  1TJV A;  4V2Q A;  2FUS A;  5F92 A;  2O7E A;  2PTS A;  1YFE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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