5D6BA

Human fumarase (wild type)
Total Genus 173
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
173
sequence length
462
structure length
462
Chain Sequence
SFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAIMKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Fumarate hydratase, mitochondrial
publication title Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of recombinant human fumarase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Lyase
total genus 173
structure length 462
sequence length 462
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2015-08-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 5d6bA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 5d6bA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 5d6bA02
2O7EA 2YIIA 1C3CA 1YFMA 3NZ4A 1C3UA 4HGVA 2OHYA 1FUQA 2X75A 1GK3A 4C6GA 5F92A 1FUOA 1TJVA 3BHGA 4C5UA 1KQ7A 2PTRA 1TJUA 2O7BA 1TJ7A 3UNVA 2E9FA 1B8FA 4CQ5A 5D6BA 4BAAA 2NYFA 3C8TA 1HY1A 4EFCA 3NO9A 4NSLA 1GKJA 4MX2A 1J3UA 1DCNA 2VD6A 2O7FA 1FURA 2PTSA 3GZHA 4APAA 4V2QA 3GTDA 3TV2A 2PTQA 1YFEA 3R6VA 4V2RA 5EYVA 1Y2MA 1DOFA 1JSWA 2RJSA 5F91A 1GK2A 1W27A 2HVGA 1TJWA 1GKMA 1HY0A 4EEIA 4FLCA 3KDZA 1T6PA 1FUPA 1U16A 3QBPA 3E04A 2J91A 3OCFA 1K7WA 4FFXA 1VDKA 3KDYA 4APBA 2O6YA 3RRPA 3CZOA 4NLEA 3R6YA 2PFMA 4BABA 1K62A 1EB4A 2O78A 4C5SA 1YISA 1Q5NA 2QGAB 2RJRA 2FUSA 5HW2A 2O7DA 2QVEA 3OCEA 4C5RA 2NYNA 3R6QA 1T6JA 5EYTA 1U15A 4ADLA 1RE5A 1AUWA 1XWOA 3RD8A 4ADMA 1I0AA
chains in the Genus database with same CATH superfamily
2O7EA 5H8WA 1Z4JA 2YIIA 1C3CA 1YFMA 3CRVA 3NZ4A 1C3UA 4L6CA 4HGVA 4YIKA 2OHYA 1FUQA 3BWVA 2X75A 1Q91A 1GK3A 4C6GA 5F92A 1FUOA 1TJVA 2I7DA 3BHGA 4MUMA 4C5UA 1KQ7A 2PTRA 1TJUA 2O7BA 5M0IA 4IQJM 1TJ7A 2JAUA 3UNVA 2E9FA 1B8FA 4CQ5A 4A15A 1T9HA 5D6BA 4BAAA 2NYFA 3F4SA 1Q92A 3C8TA 1HY1A 3F4RA 4YIHA 1IW7D 1Z4QA 4EFCA 3NO9A 4NSLA 1GKJA 4MX2A 2VSFA 1J3UA 1DCNA 2VD6A 2O7FA 1FURA 2PTSA 3GZHA 4APAA 4V2QA 1XL8A 3GTDA 3CRW1 3TV2A 2PTQA 1YFEA 3R6VA 4V2RA 2RCNA 5EYVA 1Y2MA 1DOFA 1JSWA 2RJSA 5F91A 3F4TA 4E88A 1GK2A 1W27A 1Z4IA 1Z4MA 3U19A 2HVGA 1TJWA 2JARA 2FELA 1GKMA 1HY0A 4EEIA 4FLCA 3KDZA 1T6PA 2D27A 1FUPA 1XMCA 1U0LA 5M0JA 1U16A 3QBPA 3E04A 2J91A 3OCFA 1K7WA 3CI0K 2JAWA 4MWOA 4FFXA 3U13A 1VDKA 3KDYA 2VL7A 4APBA 1XL7A 2O6YA 3RRPA 3CZOA 4NLEA 1Z4KA 3R6YA 2PFMA 4BABA 1K62A 2YV5A 1EB4A 2O78A 4C5SA 1YISA 1Z4PX 1Q5NA 2D28C 2QGAB 4L57A 2RJRA 2FUSA 5HW2A 2O7DA 2QVEA 3OCEA 4C5RA 2NYNA 4NFLA 1XMDA 1XLYA 2JAOA 3R6QA 1T6JA 2FENA 5EYTA 1Z4LA 1MH9A 4WNLA 1U15A 4ADLA 1RE5A 1AUWA 1XWOA 4L6AA 3RD8A 4ADMA 1I0AA
chains in the Genus database with same CATH topology
2O7EA 2YIIA 1C3CA 1YFMA 3NZ4A 1C3UA 4HGVA 2OHYA 1FUQA 2X75A 1GK3A 4C6GA 5F92A 1FUOA 1TJVA 3BHGA 4C5UA 1KQ7A 2PTRA 1TJUA 2O7BA 1TJ7A 3UNVA 2E9FA 1B8FA 4CQ5A 5D6BA 4BAAA 2NYFA 3C8TA 1HY1A 4EFCA 3NO9A 4NSLA 1GKJA 4MX2A 1J3UA 1DCNA 2VD6A 2O7FA 1FURA 2PTSA 3GZHA 4APAA 4V2QA 3GTDA 3TV2A 2PTQA 1YFEA 3R6VA 4V2RA 5EYVA 1Y2MA 1DOFA 1JSWA 2RJSA 5F91A 1GK2A 1W27A 2HVGA 1TJWA 1GKMA 1HY0A 4EEIA 4FLCA 3KDZA 1T6PA 1FUPA 1U16A 3QBPA 3E04A 2J91A 3OCFA 1K7WA 4FFXA 1VDKA 3KDYA 4APBA 2O6YA 3RRPA 3CZOA 4NLEA 3R6YA 2PFMA 4BABA 1K62A 1EB4A 2O78A 4C5SA 1YISA 1Q5NA 2QGAB 2RJRA 2FUSA 5HW2A 2O7DA 2QVEA 3OCEA 4C5RA 2NYNA 3R6QA 1T6JA 5EYTA 1U15A 4ADLA 1RE5A 1AUWA 1XWOA 3RD8A 4ADMA 1I0AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2O7E A;  2YII A;  1C3C A;  1YFM A;  3NZ4 A;  1C3U A;  4HGV A;  2OHY A;  1FUQ A;  2X75 A;  1GK3 A;  4C6G A;  5F92 A;  1FUO A;  1TJV A;  3BHG A;  4C5U A;  1KQ7 A;  2PTR A;  1TJU A;  2O7B A;  1TJ7 A;  3UNV A;  2E9F A;  1B8F A;  4CQ5 A;  5D6B A;  4BAA A;  2NYF A;  3C8T A;  1HY1 A;  4EFC A;  3NO9 A;  4NSL A;  1GKJ A;  4MX2 A;  1J3U A;  1DCN A;  2VD6 A;  2O7F A;  1FUR A;  2PTS A;  3GZH A;  4APA A;  4V2Q A;  3GTD A;  3TV2 A;  2PTQ A;  1YFE A;  3R6V A;  4V2R A;  5EYV A;  1Y2M A;  1DOF A;  1JSW A;  2RJS A;  5F91 A;  1GK2 A;  1W27 A;  2HVG A;  1TJW A;  1GKM A;  1HY0 A;  4EEI A;  4FLC A;  3KDZ A;  1T6P A;  1FUP A;  1U16 A;  3QBP A;  3E04 A;  2J91 A;  3OCF A;  1K7W A;  4FFX A;  1VDK A;  3KDY A;  4APB A;  2O6Y A;  3RRP A;  3CZO A;  4NLE A;  3R6Y A;  2PFM A;  4BAB A;  1K62 A;  1EB4 A;  2O78 A;  4C5S A;  1YIS A;  1Q5N A;  2QGA B;  2RJR A;  2FUS A;  5HW2 A;  2O7D A;  2QVE A;  3OCE A;  4C5R A;  2NYN A;  3R6Q A;  1T6J A;  5EYT A;  1U15 A;  4ADL A;  1RE5 A;  1AUW A;  1XWO A;  3RD8 A;  4ADM A;  1I0A A; 
#chains in the Genus database with same CATH topology
 2O7E A;  5H8W A;  1Z4J A;  2YII A;  1C3C A;  1YFM A;  3CRV A;  3NZ4 A;  1C3U A;  4L6C A;  4HGV A;  4YIK A;  2OHY A;  1FUQ A;  3BWV A;  2X75 A;  1Q91 A;  1GK3 A;  4C6G A;  5F92 A;  1FUO A;  1TJV A;  2I7D A;  3BHG A;  4MUM A;  4C5U A;  1KQ7 A;  2PTR A;  1TJU A;  2O7B A;  5M0I A;  4IQJ M;  1TJ7 A;  2JAU A;  3UNV A;  2E9F A;  1B8F A;  4CQ5 A;  4A15 A;  1T9H A;  5D6B A;  4BAA A;  2NYF A;  3F4S A;  1Q92 A;  3C8T A;  1HY1 A;  3F4R A;  4YIH A;  1IW7 D;  1Z4Q A;  4EFC A;  3NO9 A;  4NSL A;  1GKJ A;  4MX2 A;  2VSF A;  1J3U A;  1DCN A;  2VD6 A;  2O7F A;  1FUR A;  2PTS A;  3GZH A;  4APA A;  4V2Q A;  1XL8 A;  3GTD A;  3CRW 1;  3TV2 A;  2PTQ A;  1YFE A;  3R6V A;  4V2R A;  2RCN A;  5EYV A;  1Y2M A;  1DOF A;  1JSW A;  2RJS A;  5F91 A;  3F4T A;  4E88 A;  1GK2 A;  1W27 A;  1Z4I A;  1Z4M A;  3U19 A;  2HVG A;  1TJW A;  2JAR A;  2FEL A;  1GKM A;  1HY0 A;  4EEI A;  4FLC A;  3KDZ A;  1T6P A;  2D27 A;  1FUP A;  1XMC A;  1U0L A;  5M0J A;  1U16 A;  3QBP A;  3E04 A;  2J91 A;  3OCF A;  1K7W A;  3CI0 K;  2JAW A;  4MWO A;  4FFX A;  3U13 A;  1VDK A;  3KDY A;  2VL7 A;  4APB A;  1XL7 A;  2O6Y A;  3RRP A;  3CZO A;  4NLE A;  1Z4K A;  3R6Y A;  2PFM A;  4BAB A;  1K62 A;  2YV5 A;  1EB4 A;  2O78 A;  4C5S A;  1YIS A;  1Z4P X;  1Q5N A;  2D28 C;  2QGA B;  4L57 A;  2RJR A;  2FUS A;  5HW2 A;  2O7D A;  2QVE A;  3OCE A;  4C5R A;  2NYN A;  4NFL A;  1XMD A;  1XLY A;  2JAO A;  3R6Q A;  1T6J A;  2FEN A;  5EYT A;  1Z4L A;  1MH9 A;  4WNL A;  1U15 A;  4ADL A;  1RE5 A;  1AUW A;  1XWO A;  4L6A A;  3RD8 A;  4ADM A;  1I0A A; 
#chains in the Genus database with same CATH homology
 2O7E A;  2YII A;  1C3C A;  1YFM A;  3NZ4 A;  1C3U A;  4HGV A;  2OHY A;  1FUQ A;  2X75 A;  1GK3 A;  4C6G A;  5F92 A;  1FUO A;  1TJV A;  3BHG A;  4C5U A;  1KQ7 A;  2PTR A;  1TJU A;  2O7B A;  1TJ7 A;  3UNV A;  2E9F A;  1B8F A;  4CQ5 A;  5D6B A;  4BAA A;  2NYF A;  3C8T A;  1HY1 A;  4EFC A;  3NO9 A;  4NSL A;  1GKJ A;  4MX2 A;  1J3U A;  1DCN A;  2VD6 A;  2O7F A;  1FUR A;  2PTS A;  3GZH A;  4APA A;  4V2Q A;  3GTD A;  3TV2 A;  2PTQ A;  1YFE A;  3R6V A;  4V2R A;  5EYV A;  1Y2M A;  1DOF A;  1JSW A;  2RJS A;  5F91 A;  1GK2 A;  1W27 A;  2HVG A;  1TJW A;  1GKM A;  1HY0 A;  4EEI A;  4FLC A;  3KDZ A;  1T6P A;  1FUP A;  1U16 A;  3QBP A;  3E04 A;  2J91 A;  3OCF A;  1K7W A;  4FFX A;  1VDK A;  3KDY A;  4APB A;  2O6Y A;  3RRP A;  3CZO A;  4NLE A;  3R6Y A;  2PFM A;  4BAB A;  1K62 A;  1EB4 A;  2O78 A;  4C5S A;  1YIS A;  1Q5N A;  2QGA B;  2RJR A;  2FUS A;  5HW2 A;  2O7D A;  2QVE A;  3OCE A;  4C5R A;  2NYN A;  3R6Q A;  1T6J A;  5EYT A;  1U15 A;  4ADL A;  1RE5 A;  1AUW A;  1XWO A;  3RD8 A;  4ADM A;  1I0A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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