5D6BA

Human fumarase (wild type)
Total Genus 173
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
173
sequence length
462
structure length
462
Chain Sequence
SFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAIMKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lyase
source organism Homo sapiens
publication title Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of recombinant human fumarase.
pubmed doi rcsb
molecule keywords Fumarate hydratase, mitochondrial
total genus 173
structure length 462
sequence length 462
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2015-08-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 5d6bA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 5d6bA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 5d6bA02
2O78A 2VD6A 3RD8A 2O6YA 3NZ4A 2FUSA 5F91A 5EYVA 1KQ7A 1TJWA 3BHGA 4C5UA 4C5SA 3UNVA 2O7FA 2RJRA 3OCEA 3OCFA 1GKMA 2X75A 1J3UA 3R6YA 3KDYA 1U15A 1YISA 2QVEA 2J91A 1TJ7A 5F92A 4ADLA 4C6GA 1FUQA 4C5RA 3GTDA 1C3UA 1FUPA 2RJSA 1DCNA 4BABA 4APBA 1RE5A 1HY1A 1JSWA 1K62A 2E9FA 3TV2A 3KDZA 1U16A 4EFCA 4FLCA 1XWOA 4APAA 4ADMA 2OHYA 1YFMA 1FURA 1YFEA 1T6JA 1GKJA 1GK3A 2PTQA 1EB4A 2O7DA 1B8FA 1GK2A 4NLEA 3RRPA 3GZHA 4NSLA 3E04A 2PFMA 2NYNA 1K7WA 3CZOA 2NYFA 3C8TA 4V2RA 1Q5NA 4EEIA 1I0AA 3QBPA 1AUWA 2PTRA 3R6VA 5EYTA 4FFXA 1Y2MA 4BAAA 2YIIA 4CQ5A 3NO9A 1VDKA 4V2QA 1TJVA 5D6BA 1HY0A 2QGAB 1TJUA 1W27A 1T6PA 1DOFA 1FUOA 4HGVA 4MX2A 2O7BA 2O7EA 2HVGA 2PTSA 5HW2A 3R6QA 1C3CA
chains in the Genus database with same CATH superfamily
2O78A 2VD6A 3RD8A 4E88A 2O6YA 4L57A 3NZ4A 5H8WA 2FUSA 5F91A 5EYVA 2VL7A 1KQ7A 1TJWA 3BHGA 2D27A 4C5UA 1Z4KA 4C5SA 3UNVA 2O7FA 2RJRA 3OCEA 3OCFA 3CI0K 1GKMA 1XMDA 2X75A 1J3UA 3R6YA 2JARA 4YIKA 3KDYA 1U15A 1Z4LA 1YISA 2QVEA 1Z4MA 2J91A 1TJ7A 2JAWA 5F92A 2FENA 4ADLA 3U19A 4C6GA 1XMCA 1FUQA 2JAOA 4C5RA 3CRW1 3GTDA 1C3UA 2YV5A 1FUPA 2RJSA 1DCNA 4BABA 4APBA 2JAUA 1T9HA 1RE5A 1HY1A 1JSWA 1K62A 2E9FA 3TV2A 3KDZA 1U16A 3F4TA 4IQJM 4EFCA 4FLCA 1XWOA 1Z4JA 4APAA 4ADMA 1Q92A 2OHYA 1YFMA 4NFLA 4L6AA 1FURA 4WNLA 1MH9A 1YFEA 3BWVA 2FELA 1T6JA 1GKJA 3U13A 1GK3A 2PTQA 1EB4A 2O7DA 1B8FA 1GK2A 4NLEA 3RRPA 3GZHA 1XLYA 4NSLA 3E04A 4A15A 2PFMA 2NYNA 1K7WA 3CZOA 1XL8A 2NYFA 3C8TA 5M0JA 4V2RA 1Q5NA 4EEIA 1I0AA 3QBPA 1AUWA 2PTRA 3R6VA 3CRVA 5EYTA 4L6CA 4MUMA 4FFXA 1Y2MA 1Q91A 2I7DA 4MWOA 4BAAA 2YIIA 1Z4PX 2D28C 4CQ5A 3NO9A 1VDKA 1XL7A 3F4SA 1U0LA 1Z4IA 1IW7D 4V2QA 4YIHA 1TJVA 5D6BA 1HY0A 2QGAB 1TJUA 5M0IA 1W27A 1T6PA 1DOFA 1Z4QA 1FUOA 2VSFA 4HGVA 4MX2A 2O7BA 2O7EA 3F4RA 2HVGA 2RCNA 2PTSA 5HW2A 3R6QA 1C3CA
chains in the Genus database with same CATH topology
2O78A 2VD6A 3RD8A 2O6YA 3NZ4A 2FUSA 5F91A 5EYVA 1KQ7A 1TJWA 3BHGA 4C5UA 4C5SA 3UNVA 2O7FA 2RJRA 3OCEA 3OCFA 1GKMA 2X75A 1J3UA 3R6YA 3KDYA 1U15A 1YISA 2QVEA 2J91A 1TJ7A 5F92A 4ADLA 4C6GA 1FUQA 4C5RA 3GTDA 1C3UA 1FUPA 2RJSA 1DCNA 4BABA 4APBA 1RE5A 1HY1A 1JSWA 1K62A 2E9FA 3TV2A 3KDZA 1U16A 4EFCA 4FLCA 1XWOA 4APAA 4ADMA 2OHYA 1YFMA 1FURA 1YFEA 1T6JA 1GKJA 1GK3A 2PTQA 1EB4A 2O7DA 1B8FA 1GK2A 4NLEA 3RRPA 3GZHA 4NSLA 3E04A 2PFMA 2NYNA 1K7WA 3CZOA 2NYFA 3C8TA 4V2RA 1Q5NA 4EEIA 1I0AA 3QBPA 1AUWA 2PTRA 3R6VA 5EYTA 4FFXA 1Y2MA 4BAAA 2YIIA 4CQ5A 3NO9A 1VDKA 4V2QA 1TJVA 5D6BA 1HY0A 2QGAB 1TJUA 1W27A 1T6PA 1DOFA 1FUOA 4HGVA 4MX2A 2O7BA 2O7EA 2HVGA 2PTSA 5HW2A 3R6QA 1C3CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2O78 A;  2VD6 A;  3RD8 A;  2O6Y A;  3NZ4 A;  2FUS A;  5F91 A;  5EYV A;  1KQ7 A;  1TJW A;  3BHG A;  4C5U A;  4C5S A;  3UNV A;  2O7F A;  2RJR A;  3OCE A;  3OCF A;  1GKM A;  2X75 A;  1J3U A;  3R6Y A;  3KDY A;  1U15 A;  1YIS A;  2QVE A;  2J91 A;  1TJ7 A;  5F92 A;  4ADL A;  4C6G A;  1FUQ A;  4C5R A;  3GTD A;  1C3U A;  1FUP A;  2RJS A;  1DCN A;  4BAB A;  4APB A;  1RE5 A;  1HY1 A;  1JSW A;  1K62 A;  2E9F A;  3TV2 A;  3KDZ A;  1U16 A;  4EFC A;  4FLC A;  1XWO A;  4APA A;  4ADM A;  2OHY A;  1YFM A;  1FUR A;  1YFE A;  1T6J A;  1GKJ A;  1GK3 A;  2PTQ A;  1EB4 A;  2O7D A;  1B8F A;  1GK2 A;  4NLE A;  3RRP A;  3GZH A;  4NSL A;  3E04 A;  2PFM A;  2NYN A;  1K7W A;  3CZO A;  2NYF A;  3C8T A;  4V2R A;  1Q5N A;  4EEI A;  1I0A A;  3QBP A;  1AUW A;  2PTR A;  3R6V A;  5EYT A;  4FFX A;  1Y2M A;  4BAA A;  2YII A;  4CQ5 A;  3NO9 A;  1VDK A;  4V2Q A;  1TJV A;  5D6B A;  1HY0 A;  2QGA B;  1TJU A;  1W27 A;  1T6P A;  1DOF A;  1FUO A;  4HGV A;  4MX2 A;  2O7B A;  2O7E A;  2HVG A;  2PTS A;  5HW2 A;  3R6Q A;  1C3C A; 
#chains in the Genus database with same CATH topology
 2O78 A;  2VD6 A;  3RD8 A;  4E88 A;  2O6Y A;  4L57 A;  3NZ4 A;  5H8W A;  2FUS A;  5F91 A;  5EYV A;  2VL7 A;  1KQ7 A;  1TJW A;  3BHG A;  2D27 A;  4C5U A;  1Z4K A;  4C5S A;  3UNV A;  2O7F A;  2RJR A;  3OCE A;  3OCF A;  3CI0 K;  1GKM A;  1XMD A;  2X75 A;  1J3U A;  3R6Y A;  2JAR A;  4YIK A;  3KDY A;  1U15 A;  1Z4L A;  1YIS A;  2QVE A;  1Z4M A;  2J91 A;  1TJ7 A;  2JAW A;  5F92 A;  2FEN A;  4ADL A;  3U19 A;  4C6G A;  1XMC A;  1FUQ A;  2JAO A;  4C5R A;  3CRW 1;  3GTD A;  1C3U A;  2YV5 A;  1FUP A;  2RJS A;  1DCN A;  4BAB A;  4APB A;  2JAU A;  1T9H A;  1RE5 A;  1HY1 A;  1JSW A;  1K62 A;  2E9F A;  3TV2 A;  3KDZ A;  1U16 A;  3F4T A;  4IQJ M;  4EFC A;  4FLC A;  1XWO A;  1Z4J A;  4APA A;  4ADM A;  1Q92 A;  2OHY A;  1YFM A;  4NFL A;  4L6A A;  1FUR A;  4WNL A;  1MH9 A;  1YFE A;  3BWV A;  2FEL A;  1T6J A;  1GKJ A;  3U13 A;  1GK3 A;  2PTQ A;  1EB4 A;  2O7D A;  1B8F A;  1GK2 A;  4NLE A;  3RRP A;  3GZH A;  1XLY A;  4NSL A;  3E04 A;  4A15 A;  2PFM A;  2NYN A;  1K7W A;  3CZO A;  1XL8 A;  2NYF A;  3C8T A;  5M0J A;  4V2R A;  1Q5N A;  4EEI A;  1I0A A;  3QBP A;  1AUW A;  2PTR A;  3R6V A;  3CRV A;  5EYT A;  4L6C A;  4MUM A;  4FFX A;  1Y2M A;  1Q91 A;  2I7D A;  4MWO A;  4BAA A;  2YII A;  1Z4P X;  2D28 C;  4CQ5 A;  3NO9 A;  1VDK A;  1XL7 A;  3F4S A;  1U0L A;  1Z4I A;  1IW7 D;  4V2Q A;  4YIH A;  1TJV A;  5D6B A;  1HY0 A;  2QGA B;  1TJU A;  5M0I A;  1W27 A;  1T6P A;  1DOF A;  1Z4Q A;  1FUO A;  2VSF A;  4HGV A;  4MX2 A;  2O7B A;  2O7E A;  3F4R A;  2HVG A;  2RCN A;  2PTS A;  5HW2 A;  3R6Q A;  1C3C A; 
#chains in the Genus database with same CATH homology
 2O78 A;  2VD6 A;  3RD8 A;  2O6Y A;  3NZ4 A;  2FUS A;  5F91 A;  5EYV A;  1KQ7 A;  1TJW A;  3BHG A;  4C5U A;  4C5S A;  3UNV A;  2O7F A;  2RJR A;  3OCE A;  3OCF A;  1GKM A;  2X75 A;  1J3U A;  3R6Y A;  3KDY A;  1U15 A;  1YIS A;  2QVE A;  2J91 A;  1TJ7 A;  5F92 A;  4ADL A;  4C6G A;  1FUQ A;  4C5R A;  3GTD A;  1C3U A;  1FUP A;  2RJS A;  1DCN A;  4BAB A;  4APB A;  1RE5 A;  1HY1 A;  1JSW A;  1K62 A;  2E9F A;  3TV2 A;  3KDZ A;  1U16 A;  4EFC A;  4FLC A;  1XWO A;  4APA A;  4ADM A;  2OHY A;  1YFM A;  1FUR A;  1YFE A;  1T6J A;  1GKJ A;  1GK3 A;  2PTQ A;  1EB4 A;  2O7D A;  1B8F A;  1GK2 A;  4NLE A;  3RRP A;  3GZH A;  4NSL A;  3E04 A;  2PFM A;  2NYN A;  1K7W A;  3CZO A;  2NYF A;  3C8T A;  4V2R A;  1Q5N A;  4EEI A;  1I0A A;  3QBP A;  1AUW A;  2PTR A;  3R6V A;  5EYT A;  4FFX A;  1Y2M A;  4BAA A;  2YII A;  4CQ5 A;  3NO9 A;  1VDK A;  4V2Q A;  1TJV A;  5D6B A;  1HY0 A;  2QGA B;  1TJU A;  1W27 A;  1T6P A;  1DOF A;  1FUO A;  4HGV A;  4MX2 A;  2O7B A;  2O7E A;  2HVG A;  2PTS A;  5HW2 A;  3R6Q A;  1C3C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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