5D6BA

Human fumarase (wild type)
Total Genus 173
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
173
sequence length
462
structure length
462
Chain Sequence
SFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAIMKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of recombinant human fumarase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Lyase
molecule keywords Fumarate hydratase, mitochondrial
total genus 173
structure length 462
sequence length 462
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2015-08-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 5d6bA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 5d6bA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 5d6bA02
3R6YA 1FUQA 1I0AA 3E04A 1C3UA 2PTRA 2RJRA 3GTDA 4APAA 1Y2MA 1JSWA 1YFEA 4NLEA 3RD8A 1B8FA 3NZ4A 3R6VA 1HY1A 1TJWA 4EEIA 1DCNA 4APBA 4BAAA 2O7FA 2OHYA 2O7EA 1T6PA 1TJ7A 3R6QA 2PFMA 1Q5NA 1U15A 1VDKA 2VD6A 1W27A 2E9FA 1AUWA 3GZHA 3QBPA 4HGVA 1DOFA 5F91A 4V2RA 2O7BA 1HY0A 2O78A 3CZOA 4NSLA 3BHGA 4CQ5A 1YFMA 4C5UA 1FUOA 2NYNA 4C6GA 2HVGA 3TV2A 1KQ7A 3OCFA 4FLCA 2X75A 2YIIA 5EYVA 1XWOA 2O7DA 2PTSA 1TJUA 4BABA 5HW2A 1K7WA 1GK2A 5D6BA 1EB4A 1FURA 3RRPA 3OCEA 1GKMA 2PTQA 1GK3A 1T6JA 4FFXA 2QVEA 3UNVA 1GKJA 3KDYA 1FUPA 1RE5A 1J3UA 2NYFA 4C5RA 5F92A 4V2QA 4ADLA 2J91A 2QGAB 3KDZA 2FUSA 4C5SA 1TJVA 2O6YA 5EYTA 1YISA 2RJSA 3C8TA 1K62A 1U16A 4EFCA 1C3CA 4ADMA 4MX2A 3NO9A
chains in the Genus database with same CATH superfamily
3R6YA 1FUQA 1I0AA 3E04A 1C3UA 2PTRA 1XL7A 2RJRA 3GTDA 4APAA 1MH9A 1JSWA 1Y2MA 1YFEA 4NLEA 3RD8A 1B8FA 3NZ4A 2I7DA 3R6VA 1HY1A 5M0JA 1TJWA 4L6CA 4EEIA 1DCNA 4APBA 4BAAA 1Z4MA 3U13A 2O7FA 1Q91A 2FENA 2OHYA 2O7EA 1T6PA 1TJ7A 3R6QA 2PFMA 1Q5NA 1U15A 1VDKA 2VD6A 1W27A 5M0IA 2E9FA 1AUWA 3GZHA 3QBPA 4HGVA 1DOFA 1U0LA 5F91A 4YIKA 4V2RA 2O7BA 1HY0A 2YV5A 2O78A 3U19A 3CZOA 4NSLA 3BHGA 1Z4KA 3CI0K 1Z4LA 4CQ5A 1YFMA 4E88A 1FUOA 2NYNA 1Z4JA 4C6GA 4C5UA 2HVGA 3TV2A 1KQ7A 3OCFA 4FLCA 2X75A 2FELA 2D28C 4A15A 1Z4IA 2YIIA 5EYVA 2JAOA 1XWOA 2O7DA 2PTSA 2JARA 1TJUA 4BABA 2JAUA 1K7WA 5HW2A 5D6BA 1GK2A 3CRW1 2VSFA 1EB4A 4MUMA 1XMDA 1FURA 3RRPA 3OCEA 3F4SA 1Z4QA 2PTQA 4L6AA 1GK3A 1GKMA 1IW7D 4MWOA 1T6JA 4FFXA 3BWVA 2QVEA 3UNVA 1GKJA 1Q92A 3KDYA 1FUPA 2RCNA 1RE5A 1J3UA 2NYFA 4C5RA 5H8WA 5F92A 4V2QA 1XLYA 4ADLA 2J91A 2QGAB 3KDZA 4NFLA 4YIHA 2FUSA 3F4TA 4C5SA 1TJVA 1Z4PX 2O6YA 1XL8A 4WNLA 5EYTA 1YISA 2RJSA 2JAWA 2VL7A 4L57A 3C8TA 1K62A 1XMCA 3F4RA 1U16A 4EFCA 1T9HA 3CRVA 1C3CA 2D27A 4ADMA 4IQJM 4MX2A 3NO9A
chains in the Genus database with same CATH topology
3R6YA 1FUQA 1I0AA 3E04A 1C3UA 2PTRA 2RJRA 3GTDA 4APAA 1Y2MA 1JSWA 1YFEA 4NLEA 3RD8A 1B8FA 3NZ4A 3R6VA 1HY1A 1TJWA 4EEIA 1DCNA 4APBA 4BAAA 2O7FA 2OHYA 2O7EA 1T6PA 1TJ7A 3R6QA 2PFMA 1Q5NA 1U15A 1VDKA 2VD6A 1W27A 2E9FA 1AUWA 3GZHA 3QBPA 4HGVA 1DOFA 5F91A 4V2RA 2O7BA 1HY0A 2O78A 3CZOA 4NSLA 3BHGA 4CQ5A 1YFMA 4C5UA 1FUOA 2NYNA 4C6GA 2HVGA 3TV2A 1KQ7A 3OCFA 4FLCA 2X75A 2YIIA 5EYVA 1XWOA 2O7DA 2PTSA 1TJUA 4BABA 5HW2A 1K7WA 1GK2A 5D6BA 1EB4A 1FURA 3RRPA 3OCEA 1GKMA 2PTQA 1GK3A 1T6JA 4FFXA 2QVEA 3UNVA 1GKJA 3KDYA 1FUPA 1RE5A 1J3UA 2NYFA 4C5RA 5F92A 4V2QA 4ADLA 2J91A 2QGAB 3KDZA 2FUSA 4C5SA 1TJVA 2O6YA 5EYTA 1YISA 2RJSA 3C8TA 1K62A 1U16A 4EFCA 1C3CA 4ADMA 4MX2A 3NO9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3R6Y A;  1FUQ A;  1I0A A;  3E04 A;  1C3U A;  2PTR A;  2RJR A;  3GTD A;  4APA A;  1Y2M A;  1JSW A;  1YFE A;  4NLE A;  3RD8 A;  1B8F A;  3NZ4 A;  3R6V A;  1HY1 A;  1TJW A;  4EEI A;  1DCN A;  4APB A;  4BAA A;  2O7F A;  2OHY A;  2O7E A;  1T6P A;  1TJ7 A;  3R6Q A;  2PFM A;  1Q5N A;  1U15 A;  1VDK A;  2VD6 A;  1W27 A;  2E9F A;  1AUW A;  3GZH A;  3QBP A;  4HGV A;  1DOF A;  5F91 A;  4V2R A;  2O7B A;  1HY0 A;  2O78 A;  3CZO A;  4NSL A;  3BHG A;  4CQ5 A;  1YFM A;  4C5U A;  1FUO A;  2NYN A;  4C6G A;  2HVG A;  3TV2 A;  1KQ7 A;  3OCF A;  4FLC A;  2X75 A;  2YII A;  5EYV A;  1XWO A;  2O7D A;  2PTS A;  1TJU A;  4BAB A;  5HW2 A;  1K7W A;  1GK2 A;  5D6B A;  1EB4 A;  1FUR A;  3RRP A;  3OCE A;  1GKM A;  2PTQ A;  1GK3 A;  1T6J A;  4FFX A;  2QVE A;  3UNV A;  1GKJ A;  3KDY A;  1FUP A;  1RE5 A;  1J3U A;  2NYF A;  4C5R A;  5F92 A;  4V2Q A;  4ADL A;  2J91 A;  2QGA B;  3KDZ A;  2FUS A;  4C5S A;  1TJV A;  2O6Y A;  5EYT A;  1YIS A;  2RJS A;  3C8T A;  1K62 A;  1U16 A;  4EFC A;  1C3C A;  4ADM A;  4MX2 A;  3NO9 A; 
#chains in the Genus database with same CATH topology
 3R6Y A;  1FUQ A;  1I0A A;  3E04 A;  1C3U A;  2PTR A;  1XL7 A;  2RJR A;  3GTD A;  4APA A;  1MH9 A;  1JSW A;  1Y2M A;  1YFE A;  4NLE A;  3RD8 A;  1B8F A;  3NZ4 A;  2I7D A;  3R6V A;  1HY1 A;  5M0J A;  1TJW A;  4L6C A;  4EEI A;  1DCN A;  4APB A;  4BAA A;  1Z4M A;  3U13 A;  2O7F A;  1Q91 A;  2FEN A;  2OHY A;  2O7E A;  1T6P A;  1TJ7 A;  3R6Q A;  2PFM A;  1Q5N A;  1U15 A;  1VDK A;  2VD6 A;  1W27 A;  5M0I A;  2E9F A;  1AUW A;  3GZH A;  3QBP A;  4HGV A;  1DOF A;  1U0L A;  5F91 A;  4YIK A;  4V2R A;  2O7B A;  1HY0 A;  2YV5 A;  2O78 A;  3U19 A;  3CZO A;  4NSL A;  3BHG A;  1Z4K A;  3CI0 K;  1Z4L A;  4CQ5 A;  1YFM A;  4E88 A;  1FUO A;  2NYN A;  1Z4J A;  4C6G A;  4C5U A;  2HVG A;  3TV2 A;  1KQ7 A;  3OCF A;  4FLC A;  2X75 A;  2FEL A;  2D28 C;  4A15 A;  1Z4I A;  2YII A;  5EYV A;  2JAO A;  1XWO A;  2O7D A;  2PTS A;  2JAR A;  1TJU A;  4BAB A;  2JAU A;  1K7W A;  5HW2 A;  5D6B A;  1GK2 A;  3CRW 1;  2VSF A;  1EB4 A;  4MUM A;  1XMD A;  1FUR A;  3RRP A;  3OCE A;  3F4S A;  1Z4Q A;  2PTQ A;  4L6A A;  1GK3 A;  1GKM A;  1IW7 D;  4MWO A;  1T6J A;  4FFX A;  3BWV A;  2QVE A;  3UNV A;  1GKJ A;  1Q92 A;  3KDY A;  1FUP A;  2RCN A;  1RE5 A;  1J3U A;  2NYF A;  4C5R A;  5H8W A;  5F92 A;  4V2Q A;  1XLY A;  4ADL A;  2J91 A;  2QGA B;  3KDZ A;  4NFL A;  4YIH A;  2FUS A;  3F4T A;  4C5S A;  1TJV A;  1Z4P X;  2O6Y A;  1XL8 A;  4WNL A;  5EYT A;  1YIS A;  2RJS A;  2JAW A;  2VL7 A;  4L57 A;  3C8T A;  1K62 A;  1XMC A;  3F4R A;  1U16 A;  4EFC A;  1T9H A;  3CRV A;  1C3C A;  2D27 A;  4ADM A;  4IQJ M;  4MX2 A;  3NO9 A; 
#chains in the Genus database with same CATH homology
 3R6Y A;  1FUQ A;  1I0A A;  3E04 A;  1C3U A;  2PTR A;  2RJR A;  3GTD A;  4APA A;  1Y2M A;  1JSW A;  1YFE A;  4NLE A;  3RD8 A;  1B8F A;  3NZ4 A;  3R6V A;  1HY1 A;  1TJW A;  4EEI A;  1DCN A;  4APB A;  4BAA A;  2O7F A;  2OHY A;  2O7E A;  1T6P A;  1TJ7 A;  3R6Q A;  2PFM A;  1Q5N A;  1U15 A;  1VDK A;  2VD6 A;  1W27 A;  2E9F A;  1AUW A;  3GZH A;  3QBP A;  4HGV A;  1DOF A;  5F91 A;  4V2R A;  2O7B A;  1HY0 A;  2O78 A;  3CZO A;  4NSL A;  3BHG A;  4CQ5 A;  1YFM A;  4C5U A;  1FUO A;  2NYN A;  4C6G A;  2HVG A;  3TV2 A;  1KQ7 A;  3OCF A;  4FLC A;  2X75 A;  2YII A;  5EYV A;  1XWO A;  2O7D A;  2PTS A;  1TJU A;  4BAB A;  5HW2 A;  1K7W A;  1GK2 A;  5D6B A;  1EB4 A;  1FUR A;  3RRP A;  3OCE A;  1GKM A;  2PTQ A;  1GK3 A;  1T6J A;  4FFX A;  2QVE A;  3UNV A;  1GKJ A;  3KDY A;  1FUP A;  1RE5 A;  1J3U A;  2NYF A;  4C5R A;  5F92 A;  4V2Q A;  4ADL A;  2J91 A;  2QGA B;  3KDZ A;  2FUS A;  4C5S A;  1TJV A;  2O6Y A;  5EYT A;  1YIS A;  2RJS A;  3C8T A;  1K62 A;  1U16 A;  4EFC A;  1C3C A;  4ADM A;  4MX2 A;  3NO9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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