4APBA

Crystal structure of mycobacterium tuberculosis fumarase (rv1098c) s318c in complex with fumarate
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
sequence length
460
structure length
460
Chain Sequence
NYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGCSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords FUMARATE HYDRATASE CLASS II
publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
total genus 177
structure length 460
sequence length 460
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2012-03-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4apbA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4apbA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4apbA02
1U16A 1J3UA 4HGVA 4ADMA 2VD6A 5HW2A 4APAA 2RJSA 3KDYA 4CQ5A 1I0AA 5F91A 1U15A 1K7WA 1FUOA 1TJVA 2NYFA 4C6GA 2YIIA 1YISA 1FUQA 4BAAA 1XWOA 4C5SA 2QGAB 3RD8A 2OHYA 2E9FA 1DCNA 4FLCA 2NYNA 1JSWA 1AUWA 3R6YA 1YFMA 5EYVA 2PFMA 4NSLA 2O7DA 3OCFA 4BABA 2PTQA 3E04A 4FFXA 1HY1A 1Y2MA 3TV2A 3R6QA 4V2RA 2O7BA 3CZOA 1Q5NA 1RE5A 1C3CA 2O7EA 1FURA 1GK2A 4EEIA 2O7FA 1KQ7A 2FUSA 4MX2A 2PTSA 4ADLA 2O6YA 3R6VA 1B8FA 2X75A 3NZ4A 3KDZA 5D6BA 1YFEA 3QBPA 3GTDA 3UNVA 1C3UA 4NLEA 1GKJA 2O78A 1GK3A 4V2QA 5EYTA 3RRPA 2QVEA 1TJ7A 3OCEA 4APBA 1VDKA 2PTRA 3NO9A 2HVGA 1T6JA 3BHGA 2J91A 1T6PA 3C8TA 4EFCA 1FUPA 1K62A 1DOFA 1W27A 1HY0A 1TJWA 2RJRA 3GZHA 4C5RA 5F92A 1TJUA 4C5UA 1EB4A 1GKMA
chains in the Genus database with same CATH superfamily
1U16A 1J3UA 4HGVA 4ADMA 1XMCA 2VD6A 5HW2A 4APAA 5H8WA 2RJSA 3KDYA 4CQ5A 1I0AA 5F91A 1U15A 2I7DA 1K7WA 4A15A 3F4RA 1Z4QA 1Z4LA 4L6CA 1FUOA 1TJVA 2NYFA 4C6GA 4MUMA 4YIKA 2YIIA 1YISA 1FUQA 4BAAA 1Z4PX 1XWOA 4C5SA 2QGAB 3RD8A 2OHYA 5M0IA 2E9FA 1IW7D 1DCNA 4FLCA 2NYNA 1JSWA 1Z4IA 3CRVA 3R6YA 1YFMA 5EYVA 2PFMA 4NSLA 4IQJM 2O7DA 2JAUA 3OCFA 4BABA 2PTQA 3E04A 3U19A 4FFXA 1HY1A 4L57A 4WNLA 1Y2MA 3TV2A 4NFLA 5M0JA 3R6QA 4V2RA 2O7BA 3CZOA 1Q5NA 2VSFA 1RE5A 1C3CA 3CI0K 2O7EA 2VL7A 1FURA 1GK2A 4EEIA 1XMDA 1GKMA 2O7FA 1Q91A 1KQ7A 2FUSA 4MX2A 2PTSA 3CRW1 4ADLA 2O6YA 3R6VA 1B8FA 2X75A 3NZ4A 1EB4A 5D6BA 3KDZA 1T9HA 1YFEA 3QBPA 3GTDA 3U13A 3UNVA 1MH9A 2JARA 1Z4MA 3BWVA 1C3UA 4NLEA 1GKJA 2O78A 3F4SA 1U0LA 1GK3A 4V2QA 5EYTA 3F4TA 3RRPA 2QVEA 1XL7A 1TJ7A 3OCEA 4APBA 1VDKA 2PTRA 2JAOA 2RCNA 1Z4KA 2HVGA 3NO9A 1T6JA 3BHGA 1Z4JA 1Q92A 2J91A 4L6AA 1T6PA 3C8TA 4EFCA 1FUPA 1K62A 2D27A 2YV5A 1DOFA 1XLYA 4YIHA 2FENA 2JAWA 1W27A 1HY0A 2FELA 4MWOA 1TJWA 2RJRA 3GZHA 4C5RA 1XL8A 5F92A 1TJUA 4C5UA 1AUWA 4E88A 2D28C
chains in the Genus database with same CATH topology
1U16A 1J3UA 4HGVA 4ADMA 2VD6A 5HW2A 4APAA 2RJSA 3KDYA 4CQ5A 1I0AA 5F91A 1U15A 1K7WA 1FUOA 1TJVA 2NYFA 4C6GA 2YIIA 1YISA 1FUQA 4BAAA 1XWOA 4C5SA 2QGAB 3RD8A 2OHYA 2E9FA 1DCNA 4FLCA 2NYNA 1JSWA 1AUWA 3R6YA 1YFMA 5EYVA 2PFMA 4NSLA 2O7DA 3OCFA 4BABA 2PTQA 3E04A 4FFXA 1HY1A 1Y2MA 3TV2A 3R6QA 4V2RA 2O7BA 3CZOA 1Q5NA 1RE5A 1C3CA 2O7EA 1FURA 1GK2A 4EEIA 2O7FA 1KQ7A 2FUSA 4MX2A 2PTSA 4ADLA 2O6YA 3R6VA 1B8FA 2X75A 3NZ4A 3KDZA 5D6BA 1YFEA 3QBPA 3GTDA 3UNVA 1C3UA 4NLEA 1GKJA 2O78A 1GK3A 4V2QA 5EYTA 3RRPA 2QVEA 1TJ7A 3OCEA 4APBA 1VDKA 2PTRA 3NO9A 2HVGA 1T6JA 3BHGA 2J91A 1T6PA 3C8TA 4EFCA 1FUPA 1K62A 1DOFA 1W27A 1HY0A 1TJWA 2RJRA 3GZHA 4C5RA 5F92A 1TJUA 4C5UA 1EB4A 1GKMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1U16 A;  1J3U A;  4HGV A;  4ADM A;  2VD6 A;  5HW2 A;  4APA A;  2RJS A;  3KDY A;  4CQ5 A;  1I0A A;  5F91 A;  1U15 A;  1K7W A;  1FUO A;  1TJV A;  2NYF A;  4C6G A;  2YII A;  1YIS A;  1FUQ A;  4BAA A;  1XWO A;  4C5S A;  2QGA B;  3RD8 A;  2OHY A;  2E9F A;  1DCN A;  4FLC A;  2NYN A;  1JSW A;  1AUW A;  3R6Y A;  1YFM A;  5EYV A;  2PFM A;  4NSL A;  2O7D A;  3OCF A;  4BAB A;  2PTQ A;  3E04 A;  4FFX A;  1HY1 A;  1Y2M A;  3TV2 A;  3R6Q A;  4V2R A;  2O7B A;  3CZO A;  1Q5N A;  1RE5 A;  1C3C A;  2O7E A;  1FUR A;  1GK2 A;  4EEI A;  2O7F A;  1KQ7 A;  2FUS A;  4MX2 A;  2PTS A;  4ADL A;  2O6Y A;  3R6V A;  1B8F A;  2X75 A;  3NZ4 A;  3KDZ A;  5D6B A;  1YFE A;  3QBP A;  3GTD A;  3UNV A;  1C3U A;  4NLE A;  1GKJ A;  2O78 A;  1GK3 A;  4V2Q A;  5EYT A;  3RRP A;  2QVE A;  1TJ7 A;  3OCE A;  4APB A;  1VDK A;  2PTR A;  3NO9 A;  2HVG A;  1T6J A;  3BHG A;  2J91 A;  1T6P A;  3C8T A;  4EFC A;  1FUP A;  1K62 A;  1DOF A;  1W27 A;  1HY0 A;  1TJW A;  2RJR A;  3GZH A;  4C5R A;  5F92 A;  1TJU A;  4C5U A;  1EB4 A;  1GKM A; 
#chains in the Genus database with same CATH topology
 1U16 A;  1J3U A;  4HGV A;  4ADM A;  1XMC A;  2VD6 A;  5HW2 A;  4APA A;  5H8W A;  2RJS A;  3KDY A;  4CQ5 A;  1I0A A;  5F91 A;  1U15 A;  2I7D A;  1K7W A;  4A15 A;  3F4R A;  1Z4Q A;  1Z4L A;  4L6C A;  1FUO A;  1TJV A;  2NYF A;  4C6G A;  4MUM A;  4YIK A;  2YII A;  1YIS A;  1FUQ A;  4BAA A;  1Z4P X;  1XWO A;  4C5S A;  2QGA B;  3RD8 A;  2OHY A;  5M0I A;  2E9F A;  1IW7 D;  1DCN A;  4FLC A;  2NYN A;  1JSW A;  1Z4I A;  3CRV A;  3R6Y A;  1YFM A;  5EYV A;  2PFM A;  4NSL A;  4IQJ M;  2O7D A;  2JAU A;  3OCF A;  4BAB A;  2PTQ A;  3E04 A;  3U19 A;  4FFX A;  1HY1 A;  4L57 A;  4WNL A;  1Y2M A;  3TV2 A;  4NFL A;  5M0J A;  3R6Q A;  4V2R A;  2O7B A;  3CZO A;  1Q5N A;  2VSF A;  1RE5 A;  1C3C A;  3CI0 K;  2O7E A;  2VL7 A;  1FUR A;  1GK2 A;  4EEI A;  1XMD A;  1GKM A;  2O7F A;  1Q91 A;  1KQ7 A;  2FUS A;  4MX2 A;  2PTS A;  3CRW 1;  4ADL A;  2O6Y A;  3R6V A;  1B8F A;  2X75 A;  3NZ4 A;  1EB4 A;  5D6B A;  3KDZ A;  1T9H A;  1YFE A;  3QBP A;  3GTD A;  3U13 A;  3UNV A;  1MH9 A;  2JAR A;  1Z4M A;  3BWV A;  1C3U A;  4NLE A;  1GKJ A;  2O78 A;  3F4S A;  1U0L A;  1GK3 A;  4V2Q A;  5EYT A;  3F4T A;  3RRP A;  2QVE A;  1XL7 A;  1TJ7 A;  3OCE A;  4APB A;  1VDK A;  2PTR A;  2JAO A;  2RCN A;  1Z4K A;  2HVG A;  3NO9 A;  1T6J A;  3BHG A;  1Z4J A;  1Q92 A;  2J91 A;  4L6A A;  1T6P A;  3C8T A;  4EFC A;  1FUP A;  1K62 A;  2D27 A;  2YV5 A;  1DOF A;  1XLY A;  4YIH A;  2FEN A;  2JAW A;  1W27 A;  1HY0 A;  2FEL A;  4MWO A;  1TJW A;  2RJR A;  3GZH A;  4C5R A;  1XL8 A;  5F92 A;  1TJU A;  4C5U A;  1AUW A;  4E88 A;  2D28 C; 
#chains in the Genus database with same CATH homology
 1U16 A;  1J3U A;  4HGV A;  4ADM A;  2VD6 A;  5HW2 A;  4APA A;  2RJS A;  3KDY A;  4CQ5 A;  1I0A A;  5F91 A;  1U15 A;  1K7W A;  1FUO A;  1TJV A;  2NYF A;  4C6G A;  2YII A;  1YIS A;  1FUQ A;  4BAA A;  1XWO A;  4C5S A;  2QGA B;  3RD8 A;  2OHY A;  2E9F A;  1DCN A;  4FLC A;  2NYN A;  1JSW A;  1AUW A;  3R6Y A;  1YFM A;  5EYV A;  2PFM A;  4NSL A;  2O7D A;  3OCF A;  4BAB A;  2PTQ A;  3E04 A;  4FFX A;  1HY1 A;  1Y2M A;  3TV2 A;  3R6Q A;  4V2R A;  2O7B A;  3CZO A;  1Q5N A;  1RE5 A;  1C3C A;  2O7E A;  1FUR A;  1GK2 A;  4EEI A;  2O7F A;  1KQ7 A;  2FUS A;  4MX2 A;  2PTS A;  4ADL A;  2O6Y A;  3R6V A;  1B8F A;  2X75 A;  3NZ4 A;  3KDZ A;  5D6B A;  1YFE A;  3QBP A;  3GTD A;  3UNV A;  1C3U A;  4NLE A;  1GKJ A;  2O78 A;  1GK3 A;  4V2Q A;  5EYT A;  3RRP A;  2QVE A;  1TJ7 A;  3OCE A;  4APB A;  1VDK A;  2PTR A;  3NO9 A;  2HVG A;  1T6J A;  3BHG A;  2J91 A;  1T6P A;  3C8T A;  4EFC A;  1FUP A;  1K62 A;  1DOF A;  1W27 A;  1HY0 A;  1TJW A;  2RJR A;  3GZH A;  4C5R A;  5F92 A;  1TJU A;  4C5U A;  1EB4 A;  1GKM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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