4APBA

Crystal structure of mycobacterium tuberculosis fumarase (rv1098c) s318c in complex with fumarate
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
sequence length
460
structure length
460
Chain Sequence
NYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGCSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
molecule keywords FUMARATE HYDRATASE CLASS II
total genus 177
structure length 460
sequence length 460
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2012-03-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4apbA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4apbA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4apbA02
1FUQA 4ADLA 4ADMA 5D6BA 1B8FA 3UNVA 1TJ7A 2QGAB 3NZ4A 1GKJA 4V2QA 2PTQA 1EB4A 2O7EA 2O7BA 1AUWA 4APBA 1Q5NA 4C5UA 1U16A 1HY1A 1TJVA 1FUPA 1K7WA 1TJWA 3R6QA 4EFCA 4FLCA 2RJRA 4EEIA 4HGVA 2PFMA 4APAA 1KQ7A 1C3CA 5EYVA 3R6VA 1W27A 1U15A 1GKMA 1XWOA 2VD6A 4BABA 2NYNA 2O6YA 5EYTA 3CZOA 2E9FA 1T6PA 3C8TA 1DOFA 3KDYA 2X75A 1YISA 1GK2A 3E04A 3R6YA 1K62A 3QBPA 1C3UA 4C5RA 1YFEA 2RJSA 4CQ5A 3RRPA 3TV2A 2O78A 2OHYA 2HVGA 5HW2A 2YIIA 4NSLA 1FUOA 1Y2MA 1FURA 3BHGA 1TJUA 1I0AA 1DCNA 2NYFA 3GTDA 4BAAA 4MX2A 3KDZA 5F92A 2PTSA 2FUSA 1T6JA 4C5SA 2O7DA 4NLEA 3NO9A 1J3UA 1YFMA 1HY0A 1GK3A 3OCFA 4V2RA 2QVEA 3OCEA 1RE5A 4FFXA 3GZHA 5F91A 4C6GA 2PTRA 2O7FA 2J91A 1JSWA 3RD8A 1VDKA
chains in the Genus database with same CATH superfamily
2FENA 1XMDA 1IW7D 1FUQA 4ADLA 4ADMA 2D27A 5D6BA 1B8FA 3UNVA 1TJ7A 2QGAB 3NZ4A 1GKJA 4V2QA 2PTQA 1EB4A 2O7EA 3CRVA 2O7BA 1AUWA 4A15A 4APBA 1Q5NA 4C5UA 1U16A 3CI0K 1HY1A 1TJVA 5M0JA 1FUPA 1K7WA 1TJWA 3R6QA 4MWOA 4EFCA 4FLCA 2RJRA 4MUMA 4EEIA 1XLYA 4HGVA 2JAWA 2PFMA 4APAA 1XL8A 2VL7A 1KQ7A 4L6AA 1C3CA 4YIKA 3F4TA 5EYVA 3R6VA 1W27A 1U15A 1Z4LA 1GKMA 2RCNA 1XWOA 2VD6A 2FELA 4BABA 2NYNA 1XMCA 1MH9A 2O6YA 5EYTA 3CZOA 1Z4PX 2E9FA 2VSFA 2D28C 1T6PA 4IQJM 3C8TA 1DOFA 3KDYA 4YIHA 1Z4KA 2X75A 1YISA 2JAOA 1GK2A 4L6CA 3E04A 3R6YA 1K62A 3BWVA 1Z4MA 3QBPA 1C3UA 4C5RA 1YFEA 2RJSA 4CQ5A 3RRPA 4WNLA 3TV2A 2O78A 2OHYA 2HVGA 4NFLA 5HW2A 2YIIA 4NSLA 1FUOA 1Y2MA 1FURA 2JARA 3BHGA 1TJUA 4E88A 3U19A 1Z4IA 3F4RA 1I0AA 2I7DA 5M0IA 1DCNA 2NYFA 1U0LA 3GTDA 4BAAA 1Q92A 4MX2A 3KDZA 1Q91A 1T9HA 5F92A 2PTSA 2FUSA 1Z4JA 2JAUA 3U13A 1T6JA 1XL7A 4C5SA 2YV5A 2O7DA 3CRW1 4NLEA 3NO9A 1J3UA 1YFMA 1HY0A 1GK3A 3OCFA 4V2RA 2QVEA 3OCEA 1RE5A 4FFXA 3GZHA 5F91A 4L57A 4C6GA 3F4SA 1Z4QA 2PTRA 5H8WA 2O7FA 2J91A 1JSWA 3RD8A 1VDKA
chains in the Genus database with same CATH topology
1FUQA 4ADLA 4ADMA 5D6BA 1B8FA 3UNVA 1TJ7A 2QGAB 3NZ4A 1GKJA 4V2QA 2PTQA 1EB4A 2O7EA 2O7BA 1AUWA 4APBA 1Q5NA 4C5UA 1U16A 1HY1A 1TJVA 1FUPA 1K7WA 1TJWA 3R6QA 4EFCA 4FLCA 2RJRA 4EEIA 4HGVA 2PFMA 4APAA 1KQ7A 1C3CA 5EYVA 3R6VA 1W27A 1U15A 1GKMA 1XWOA 2VD6A 4BABA 2NYNA 2O6YA 5EYTA 3CZOA 2E9FA 1T6PA 3C8TA 1DOFA 3KDYA 2X75A 1YISA 1GK2A 3E04A 3R6YA 1K62A 3QBPA 1C3UA 4C5RA 1YFEA 2RJSA 4CQ5A 3RRPA 3TV2A 2O78A 2OHYA 2HVGA 5HW2A 2YIIA 4NSLA 1FUOA 1Y2MA 1FURA 3BHGA 1TJUA 1I0AA 1DCNA 2NYFA 3GTDA 4BAAA 4MX2A 3KDZA 5F92A 2PTSA 2FUSA 1T6JA 4C5SA 2O7DA 4NLEA 3NO9A 1J3UA 1YFMA 1HY0A 1GK3A 3OCFA 4V2RA 2QVEA 3OCEA 1RE5A 4FFXA 3GZHA 5F91A 4C6GA 2PTRA 2O7FA 2J91A 1JSWA 3RD8A 1VDKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FUQ A;  4ADL A;  4ADM A;  5D6B A;  1B8F A;  3UNV A;  1TJ7 A;  2QGA B;  3NZ4 A;  1GKJ A;  4V2Q A;  2PTQ A;  1EB4 A;  2O7E A;  2O7B A;  1AUW A;  4APB A;  1Q5N A;  4C5U A;  1U16 A;  1HY1 A;  1TJV A;  1FUP A;  1K7W A;  1TJW A;  3R6Q A;  4EFC A;  4FLC A;  2RJR A;  4EEI A;  4HGV A;  2PFM A;  4APA A;  1KQ7 A;  1C3C A;  5EYV A;  3R6V A;  1W27 A;  1U15 A;  1GKM A;  1XWO A;  2VD6 A;  4BAB A;  2NYN A;  2O6Y A;  5EYT A;  3CZO A;  2E9F A;  1T6P A;  3C8T A;  1DOF A;  3KDY A;  2X75 A;  1YIS A;  1GK2 A;  3E04 A;  3R6Y A;  1K62 A;  3QBP A;  1C3U A;  4C5R A;  1YFE A;  2RJS A;  4CQ5 A;  3RRP A;  3TV2 A;  2O78 A;  2OHY A;  2HVG A;  5HW2 A;  2YII A;  4NSL A;  1FUO A;  1Y2M A;  1FUR A;  3BHG A;  1TJU A;  1I0A A;  1DCN A;  2NYF A;  3GTD A;  4BAA A;  4MX2 A;  3KDZ A;  5F92 A;  2PTS A;  2FUS A;  1T6J A;  4C5S A;  2O7D A;  4NLE A;  3NO9 A;  1J3U A;  1YFM A;  1HY0 A;  1GK3 A;  3OCF A;  4V2R A;  2QVE A;  3OCE A;  1RE5 A;  4FFX A;  3GZH A;  5F91 A;  4C6G A;  2PTR A;  2O7F A;  2J91 A;  1JSW A;  3RD8 A;  1VDK A; 
#chains in the Genus database with same CATH topology
 2FEN A;  1XMD A;  1IW7 D;  1FUQ A;  4ADL A;  4ADM A;  2D27 A;  5D6B A;  1B8F A;  3UNV A;  1TJ7 A;  2QGA B;  3NZ4 A;  1GKJ A;  4V2Q A;  2PTQ A;  1EB4 A;  2O7E A;  3CRV A;  2O7B A;  1AUW A;  4A15 A;  4APB A;  1Q5N A;  4C5U A;  1U16 A;  3CI0 K;  1HY1 A;  1TJV A;  5M0J A;  1FUP A;  1K7W A;  1TJW A;  3R6Q A;  4MWO A;  4EFC A;  4FLC A;  2RJR A;  4MUM A;  4EEI A;  1XLY A;  4HGV A;  2JAW A;  2PFM A;  4APA A;  1XL8 A;  2VL7 A;  1KQ7 A;  4L6A A;  1C3C A;  4YIK A;  3F4T A;  5EYV A;  3R6V A;  1W27 A;  1U15 A;  1Z4L A;  1GKM A;  2RCN A;  1XWO A;  2VD6 A;  2FEL A;  4BAB A;  2NYN A;  1XMC A;  1MH9 A;  2O6Y A;  5EYT A;  3CZO A;  1Z4P X;  2E9F A;  2VSF A;  2D28 C;  1T6P A;  4IQJ M;  3C8T A;  1DOF A;  3KDY A;  4YIH A;  1Z4K A;  2X75 A;  1YIS A;  2JAO A;  1GK2 A;  4L6C A;  3E04 A;  3R6Y A;  1K62 A;  3BWV A;  1Z4M A;  3QBP A;  1C3U A;  4C5R A;  1YFE A;  2RJS A;  4CQ5 A;  3RRP A;  4WNL A;  3TV2 A;  2O78 A;  2OHY A;  2HVG A;  4NFL A;  5HW2 A;  2YII A;  4NSL A;  1FUO A;  1Y2M A;  1FUR A;  2JAR A;  3BHG A;  1TJU A;  4E88 A;  3U19 A;  1Z4I A;  3F4R A;  1I0A A;  2I7D A;  5M0I A;  1DCN A;  2NYF A;  1U0L A;  3GTD A;  4BAA A;  1Q92 A;  4MX2 A;  3KDZ A;  1Q91 A;  1T9H A;  5F92 A;  2PTS A;  2FUS A;  1Z4J A;  2JAU A;  3U13 A;  1T6J A;  1XL7 A;  4C5S A;  2YV5 A;  2O7D A;  3CRW 1;  4NLE A;  3NO9 A;  1J3U A;  1YFM A;  1HY0 A;  1GK3 A;  3OCF A;  4V2R A;  2QVE A;  3OCE A;  1RE5 A;  4FFX A;  3GZH A;  5F91 A;  4L57 A;  4C6G A;  3F4S A;  1Z4Q A;  2PTR A;  5H8W A;  2O7F A;  2J91 A;  1JSW A;  3RD8 A;  1VDK A; 
#chains in the Genus database with same CATH homology
 1FUQ A;  4ADL A;  4ADM A;  5D6B A;  1B8F A;  3UNV A;  1TJ7 A;  2QGA B;  3NZ4 A;  1GKJ A;  4V2Q A;  2PTQ A;  1EB4 A;  2O7E A;  2O7B A;  1AUW A;  4APB A;  1Q5N A;  4C5U A;  1U16 A;  1HY1 A;  1TJV A;  1FUP A;  1K7W A;  1TJW A;  3R6Q A;  4EFC A;  4FLC A;  2RJR A;  4EEI A;  4HGV A;  2PFM A;  4APA A;  1KQ7 A;  1C3C A;  5EYV A;  3R6V A;  1W27 A;  1U15 A;  1GKM A;  1XWO A;  2VD6 A;  4BAB A;  2NYN A;  2O6Y A;  5EYT A;  3CZO A;  2E9F A;  1T6P A;  3C8T A;  1DOF A;  3KDY A;  2X75 A;  1YIS A;  1GK2 A;  3E04 A;  3R6Y A;  1K62 A;  3QBP A;  1C3U A;  4C5R A;  1YFE A;  2RJS A;  4CQ5 A;  3RRP A;  3TV2 A;  2O78 A;  2OHY A;  2HVG A;  5HW2 A;  2YII A;  4NSL A;  1FUO A;  1Y2M A;  1FUR A;  3BHG A;  1TJU A;  1I0A A;  1DCN A;  2NYF A;  3GTD A;  4BAA A;  4MX2 A;  3KDZ A;  5F92 A;  2PTS A;  2FUS A;  1T6J A;  4C5S A;  2O7D A;  4NLE A;  3NO9 A;  1J3U A;  1YFM A;  1HY0 A;  1GK3 A;  3OCF A;  4V2R A;  2QVE A;  3OCE A;  1RE5 A;  4FFX A;  3GZH A;  5F91 A;  4C6G A;  2PTR A;  2O7F A;  2J91 A;  1JSW A;  3RD8 A;  1VDK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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