4APBA

Crystal structure of mycobacterium tuberculosis fumarase (rv1098c) s318c in complex with fumarate
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
sequence length
460
structure length
460
Chain Sequence
NYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGCSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
molecule keywords FUMARATE HYDRATASE CLASS II
total genus 177
structure length 460
sequence length 460
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2012-03-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4apbA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4apbA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4apbA02
5HW2A 1K62A 1B8FA 1GKJA 1XWOA 4C5SA 2PFMA 1KQ7A 4FLCA 2HVGA 1J3UA 5EYTA 2O6YA 3KDYA 2QGAB 2FUSA 1YFMA 1T6JA 2O7DA 4NSLA 3R6VA 1JSWA 4NLEA 2NYFA 2O7FA 4ADMA 2PTQA 1YISA 3BHGA 2QVEA 3E04A 1C3CA 1TJ7A 2O7EA 4C6GA 1FUOA 1TJUA 2YIIA 1FURA 1U16A 2RJSA 2RJRA 3CZOA 1GK3A 3UNVA 1FUQA 2VD6A 3GZHA 5EYVA 2O78A 4FFXA 3TV2A 1U15A 4V2QA 3OCEA 1DCNA 3R6YA 5F91A 3OCFA 4APAA 5F92A 2OHYA 3NO9A 2PTRA 2J91A 4MX2A 1FUPA 3C8TA 1TJVA 2PTSA 3R6QA 1GKMA 4CQ5A 3QBPA 2E9FA 2NYNA 1EB4A 3RRPA 4V2RA 1AUWA 1DOFA 1YFEA 4BAAA 2O7BA 1K7WA 4ADLA 3KDZA 1GK2A 3RD8A 1HY0A 1W27A 1RE5A 1Y2MA 1I0AA 4HGVA 4APBA 4C5UA 5D6BA 4BABA 1T6PA 4EEIA 4EFCA 1C3UA 1HY1A 3NZ4A 1VDKA 1TJWA 3GTDA 2X75A 1Q5NA 4C5RA
chains in the Genus database with same CATH superfamily
5HW2A 1K62A 1B8FA 1GKJA 1XMDA 1XWOA 3U19A 4C5SA 2PFMA 1KQ7A 4FLCA 2HVGA 1J3UA 2YV5A 3F4TA 5EYTA 2O6YA 3KDYA 4YIKA 4L6AA 2QGAB 2FUSA 1YFMA 1T6JA 2O7DA 1Z4KA 4NSLA 3R6VA 1JSWA 4NLEA 3U13A 1XL8A 2NYFA 2O7FA 4MWOA 2PTQA 2RCNA 4ADMA 1YISA 5M0JA 1Z4LA 3BHGA 2JAWA 2QVEA 3E04A 1C3CA 4NFLA 1TJ7A 2O7EA 4C6GA 2FENA 1FUOA 1IW7D 1TJUA 2JARA 4YIHA 4IQJM 1T9HA 1Q92A 5M0IA 2YIIA 1FURA 1U16A 2RJSA 2RJRA 3CZOA 1GK3A 4L57A 3UNVA 2D28C 1FUQA 2VD6A 3GZHA 5EYVA 4A15A 2VSFA 2JAOA 2O78A 3F4RA 4FFXA 1XL7A 3TV2A 1U15A 4V2QA 3OCEA 1DCNA 3R6YA 5F91A 3OCFA 4APAA 5F92A 1Z4MA 3NO9A 2PTRA 2OHYA 2J91A 4MX2A 1FUPA 2VL7A 3C8TA 1XLYA 3F4SA 1MH9A 1TJVA 2D27A 2PTSA 3R6QA 3CRVA 1GKMA 4CQ5A 3QBPA 2E9FA 2NYNA 4WNLA 1EB4A 3CRW1 3RRPA 4V2RA 4L6CA 1AUWA 2JAUA 1DOFA 1XMCA 1YFEA 4BAAA 2FELA 2O7BA 1K7WA 4ADLA 3KDZA 1GK2A 3RD8A 4MUMA 1HY0A 1W27A 1RE5A 1Y2MA 3BWVA 1I0AA 5H8WA 4HGVA 4APBA 3CI0K 5D6BA 4BABA 1T6PA 4C5UA 1Z4IA 4EEIA 4EFCA 1Q91A 1Z4JA 1C3UA 1HY1A 1U0LA 2I7DA 1Z4PX 3NZ4A 1Z4QA 1VDKA 1TJWA 3GTDA 4E88A 2X75A 1Q5NA 4C5RA
chains in the Genus database with same CATH topology
5HW2A 1K62A 1B8FA 1GKJA 1XWOA 4C5SA 2PFMA 1KQ7A 4FLCA 2HVGA 1J3UA 5EYTA 2O6YA 3KDYA 2QGAB 2FUSA 1YFMA 1T6JA 2O7DA 4NSLA 3R6VA 1JSWA 4NLEA 2NYFA 2O7FA 4ADMA 2PTQA 1YISA 3BHGA 2QVEA 3E04A 1C3CA 1TJ7A 2O7EA 4C6GA 1FUOA 1TJUA 2YIIA 1FURA 1U16A 2RJSA 2RJRA 3CZOA 1GK3A 3UNVA 1FUQA 2VD6A 3GZHA 5EYVA 2O78A 4FFXA 3TV2A 1U15A 4V2QA 3OCEA 1DCNA 3R6YA 5F91A 3OCFA 4APAA 5F92A 2OHYA 3NO9A 2PTRA 2J91A 4MX2A 1FUPA 3C8TA 1TJVA 2PTSA 3R6QA 1GKMA 4CQ5A 3QBPA 2E9FA 2NYNA 1EB4A 3RRPA 4V2RA 1AUWA 1DOFA 1YFEA 4BAAA 2O7BA 1K7WA 4ADLA 3KDZA 1GK2A 3RD8A 1HY0A 1W27A 1RE5A 1Y2MA 1I0AA 4HGVA 4APBA 4C5UA 5D6BA 4BABA 1T6PA 4EEIA 4EFCA 1C3UA 1HY1A 3NZ4A 1VDKA 1TJWA 3GTDA 2X75A 1Q5NA 4C5RA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HW2 A;  1K62 A;  1B8F A;  1GKJ A;  1XWO A;  4C5S A;  2PFM A;  1KQ7 A;  4FLC A;  2HVG A;  1J3U A;  5EYT A;  2O6Y A;  3KDY A;  2QGA B;  2FUS A;  1YFM A;  1T6J A;  2O7D A;  4NSL A;  3R6V A;  1JSW A;  4NLE A;  2NYF A;  2O7F A;  4ADM A;  2PTQ A;  1YIS A;  3BHG A;  2QVE A;  3E04 A;  1C3C A;  1TJ7 A;  2O7E A;  4C6G A;  1FUO A;  1TJU A;  2YII A;  1FUR A;  1U16 A;  2RJS A;  2RJR A;  3CZO A;  1GK3 A;  3UNV A;  1FUQ A;  2VD6 A;  3GZH A;  5EYV A;  2O78 A;  4FFX A;  3TV2 A;  1U15 A;  4V2Q A;  3OCE A;  1DCN A;  3R6Y A;  5F91 A;  3OCF A;  4APA A;  5F92 A;  2OHY A;  3NO9 A;  2PTR A;  2J91 A;  4MX2 A;  1FUP A;  3C8T A;  1TJV A;  2PTS A;  3R6Q A;  1GKM A;  4CQ5 A;  3QBP A;  2E9F A;  2NYN A;  1EB4 A;  3RRP A;  4V2R A;  1AUW A;  1DOF A;  1YFE A;  4BAA A;  2O7B A;  1K7W A;  4ADL A;  3KDZ A;  1GK2 A;  3RD8 A;  1HY0 A;  1W27 A;  1RE5 A;  1Y2M A;  1I0A A;  4HGV A;  4APB A;  4C5U A;  5D6B A;  4BAB A;  1T6P A;  4EEI A;  4EFC A;  1C3U A;  1HY1 A;  3NZ4 A;  1VDK A;  1TJW A;  3GTD A;  2X75 A;  1Q5N A;  4C5R A; 
#chains in the Genus database with same CATH topology
 5HW2 A;  1K62 A;  1B8F A;  1GKJ A;  1XMD A;  1XWO A;  3U19 A;  4C5S A;  2PFM A;  1KQ7 A;  4FLC A;  2HVG A;  1J3U A;  2YV5 A;  3F4T A;  5EYT A;  2O6Y A;  3KDY A;  4YIK A;  4L6A A;  2QGA B;  2FUS A;  1YFM A;  1T6J A;  2O7D A;  1Z4K A;  4NSL A;  3R6V A;  1JSW A;  4NLE A;  3U13 A;  1XL8 A;  2NYF A;  2O7F A;  4MWO A;  2PTQ A;  2RCN A;  4ADM A;  1YIS A;  5M0J A;  1Z4L A;  3BHG A;  2JAW A;  2QVE A;  3E04 A;  1C3C A;  4NFL A;  1TJ7 A;  2O7E A;  4C6G A;  2FEN A;  1FUO A;  1IW7 D;  1TJU A;  2JAR A;  4YIH A;  4IQJ M;  1T9H A;  1Q92 A;  5M0I A;  2YII A;  1FUR A;  1U16 A;  2RJS A;  2RJR A;  3CZO A;  1GK3 A;  4L57 A;  3UNV A;  2D28 C;  1FUQ A;  2VD6 A;  3GZH A;  5EYV A;  4A15 A;  2VSF A;  2JAO A;  2O78 A;  3F4R A;  4FFX A;  1XL7 A;  3TV2 A;  1U15 A;  4V2Q A;  3OCE A;  1DCN A;  3R6Y A;  5F91 A;  3OCF A;  4APA A;  5F92 A;  1Z4M A;  3NO9 A;  2PTR A;  2OHY A;  2J91 A;  4MX2 A;  1FUP A;  2VL7 A;  3C8T A;  1XLY A;  3F4S A;  1MH9 A;  1TJV A;  2D27 A;  2PTS A;  3R6Q A;  3CRV A;  1GKM A;  4CQ5 A;  3QBP A;  2E9F A;  2NYN A;  4WNL A;  1EB4 A;  3CRW 1;  3RRP A;  4V2R A;  4L6C A;  1AUW A;  2JAU A;  1DOF A;  1XMC A;  1YFE A;  4BAA A;  2FEL A;  2O7B A;  1K7W A;  4ADL A;  3KDZ A;  1GK2 A;  3RD8 A;  4MUM A;  1HY0 A;  1W27 A;  1RE5 A;  1Y2M A;  3BWV A;  1I0A A;  5H8W A;  4HGV A;  4APB A;  3CI0 K;  5D6B A;  4BAB A;  1T6P A;  4C5U A;  1Z4I A;  4EEI A;  4EFC A;  1Q91 A;  1Z4J A;  1C3U A;  1HY1 A;  1U0L A;  2I7D A;  1Z4P X;  3NZ4 A;  1Z4Q A;  1VDK A;  1TJW A;  3GTD A;  4E88 A;  2X75 A;  1Q5N A;  4C5R A; 
#chains in the Genus database with same CATH homology
 5HW2 A;  1K62 A;  1B8F A;  1GKJ A;  1XWO A;  4C5S A;  2PFM A;  1KQ7 A;  4FLC A;  2HVG A;  1J3U A;  5EYT A;  2O6Y A;  3KDY A;  2QGA B;  2FUS A;  1YFM A;  1T6J A;  2O7D A;  4NSL A;  3R6V A;  1JSW A;  4NLE A;  2NYF A;  2O7F A;  4ADM A;  2PTQ A;  1YIS A;  3BHG A;  2QVE A;  3E04 A;  1C3C A;  1TJ7 A;  2O7E A;  4C6G A;  1FUO A;  1TJU A;  2YII A;  1FUR A;  1U16 A;  2RJS A;  2RJR A;  3CZO A;  1GK3 A;  3UNV A;  1FUQ A;  2VD6 A;  3GZH A;  5EYV A;  2O78 A;  4FFX A;  3TV2 A;  1U15 A;  4V2Q A;  3OCE A;  1DCN A;  3R6Y A;  5F91 A;  3OCF A;  4APA A;  5F92 A;  2OHY A;  3NO9 A;  2PTR A;  2J91 A;  4MX2 A;  1FUP A;  3C8T A;  1TJV A;  2PTS A;  3R6Q A;  1GKM A;  4CQ5 A;  3QBP A;  2E9F A;  2NYN A;  1EB4 A;  3RRP A;  4V2R A;  1AUW A;  1DOF A;  1YFE A;  4BAA A;  2O7B A;  1K7W A;  4ADL A;  3KDZ A;  1GK2 A;  3RD8 A;  1HY0 A;  1W27 A;  1RE5 A;  1Y2M A;  1I0A A;  4HGV A;  4APB A;  4C5U A;  5D6B A;  4BAB A;  1T6P A;  4EEI A;  4EFC A;  1C3U A;  1HY1 A;  3NZ4 A;  1VDK A;  1TJW A;  3GTD A;  2X75 A;  1Q5N A;  4C5R A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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