4APBA

Crystal structure of mycobacterium tuberculosis fumarase (rv1098c) s318c in complex with fumarate
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
sequence length
460
structure length
460
Chain Sequence
b'NYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGCSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQ'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords FUMARATE HYDRATASE CLASS II
publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
total genus 177
structure length 460
sequence length 460
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2012-03-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4apbA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4apbA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4apbA02
1K7WA 2PTSA 2O7FA 1EB4A 2FUSA 3C8TA 1U16A 1B8FA 2O7EA 4C5UA 1GKMA 2E9FA 1DCNA 2PTQA 4FLCA 1T6JA 4C5SA 1XWOA 1GK2A 1FURA 5D6BA 1GK3A 4EFCA 1KQ7A 2RJRA 2YIIA 5EYTA 1Q5NA 4APAA 2O7BA 2J91A 1YISA 3R6VA 2NYFA 1FUQA 1YFMA 5F91A 4CQ5A 3UNVA 2HVGA 2QVEA 1I0AA 3RRPA 2X75A 4EEIA 3R6QA 3NO9A 1Y2MA 3CZOA 1TJWA 1JSWA 1YFEA 4BAAA 2RJSA 1TJVA 1DOFA 1FUPA 4NLEA 2VD6A 2OHYA 1W27A 3R6YA 2PFMA 1C3UA 5EYVA 1J3UA 1U15A 1HY0A 4BABA 4HGVA 4FFXA 3BHGA 1TJ7A 3RD8A 4MX2A 4C5RA 2O6YA 4V2QA 4APBA 1T6PA 4ADMA 3NZ4A 5F92A 2PTRA 4V2RA 1VDKA 1HY1A 4C6GA 3OCEA 3QBPA 3KDZA 3GTDA 1FUOA 1RE5A 3GZHA 3E04A 3TV2A 4ADLA 2QGAB 2NYNA 2O78A 1GKJA 1AUWA 3OCFA 1TJUA 1C3CA 1K62A 4NSLA 3KDYA 2O7DA 5HW2A
chains in the Genus database with same CATH superfamily
1K7WA 2PTSA 1XMDA 2O7FA 1EB4A 2FUSA 3C8TA 2YIIA 1T9HA 1U16A 1B8FA 4L57A 2O7EA 4C5UA 1GKMA 2E9FA 1DCNA 2PTQA 4FLCA 1T6JA 2JAOA 1Z4IA 4C5SA 2FENA 1XWOA 4YIKA 1GK2A 1FURA 2FELA 1Z4JA 5D6BA 1GK3A 3U13A 1KQ7A 4L6CA 4EFCA 1XMCA 1Q5NA 4APAA 2RCNA 2O7BA 5EYTA 2D27A 2J91A 1YISA 4L6AA 1IW7D 1XLYA 3U19A 3R6VA 2NYFA 1FUQA 1YFMA 5F91A 4CQ5A 3UNVA 2HVGA 2QVEA 1I0AA 3RRPA 5H8WA 2X75A 4EEIA 3R6QA 3NO9A 1Y2MA 3CZOA 1TJWA 1Q91A 1JSWA 1Z4KA 1YFEA 4BAAA 2RJSA 1TJVA 1Z4LA 1DOFA 1FUPA 4MUMA 4NLEA 2YV5A 3CRVA 2VD6A 4E88A 3F4TA 2OHYA 5M0JA 1Z4MA 4WNLA 1W27A 3R6YA 2PFMA 1U0LA 1C3UA 4A15A 5EYVA 1J3UA 1U15A 1HY0A 4BABA 2RJRA 5M0IA 4HGVA 4FFXA 2D28C 3F4RA 3BHGA 2VSFA 2I7DA 1TJ7A 3F4SA 2JAUA 3RD8A 1Z4QA 4MX2A 2O6YA 4V2QA 4C5RA 4MWOA 4APBA 1T6PA 4ADMA 3NZ4A 5F92A 2PTRA 4V2RA 1VDKA 1HY1A 1Z4PX 1MH9A 3OCEA 4C6GA 3CRW1 3QBPA 2JAWA 3BWVA 3KDZA 4NFLA 3GTDA 1FUOA 2JARA 1RE5A 3GZHA 2VL7A 3E04A 3TV2A 4ADLA 1XL7A 2QGAB 1XL8A 2NYNA 2O78A 1GKJA 1AUWA 3CI0K 3OCFA 1TJUA 1C3CA 1K62A 4NSLA 4IQJM 3KDYA 1Q92A 2O7DA 4YIHA 5HW2A
chains in the Genus database with same CATH topology
1K7WA 2PTSA 2O7FA 1EB4A 2FUSA 3C8TA 1U16A 1B8FA 2O7EA 4C5UA 1GKMA 2E9FA 1DCNA 2PTQA 4FLCA 1T6JA 4C5SA 1XWOA 1GK2A 1FURA 5D6BA 1GK3A 4EFCA 1KQ7A 2RJRA 2YIIA 5EYTA 1Q5NA 4APAA 2O7BA 2J91A 1YISA 3R6VA 2NYFA 1FUQA 1YFMA 5F91A 4CQ5A 3UNVA 2HVGA 2QVEA 1I0AA 3RRPA 2X75A 4EEIA 3R6QA 3NO9A 1Y2MA 3CZOA 1TJWA 1JSWA 1YFEA 4BAAA 2RJSA 1TJVA 1DOFA 1FUPA 4NLEA 2VD6A 2OHYA 1W27A 3R6YA 2PFMA 1C3UA 5EYVA 1J3UA 1U15A 1HY0A 4BABA 4HGVA 4FFXA 3BHGA 1TJ7A 3RD8A 4MX2A 4C5RA 2O6YA 4V2QA 4APBA 1T6PA 4ADMA 3NZ4A 5F92A 2PTRA 4V2RA 1VDKA 1HY1A 4C6GA 3OCEA 3QBPA 3KDZA 3GTDA 1FUOA 1RE5A 3GZHA 3E04A 3TV2A 4ADLA 2QGAB 2NYNA 2O78A 1GKJA 1AUWA 3OCFA 1TJUA 1C3CA 1K62A 4NSLA 3KDYA 2O7DA 5HW2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1K7W A;  2PTS A;  2O7F A;  1EB4 A;  2FUS A;  3C8T A;  1U16 A;  1B8F A;  2O7E A;  4C5U A;  1GKM A;  2E9F A;  1DCN A;  2PTQ A;  4FLC A;  1T6J A;  4C5S A;  1XWO A;  1GK2 A;  1FUR A;  5D6B A;  1GK3 A;  4EFC A;  1KQ7 A;  2RJR A;  2YII A;  5EYT A;  1Q5N A;  4APA A;  2O7B A;  2J91 A;  1YIS A;  3R6V A;  2NYF A;  1FUQ A;  1YFM A;  5F91 A;  4CQ5 A;  3UNV A;  2HVG A;  2QVE A;  1I0A A;  3RRP A;  2X75 A;  4EEI A;  3R6Q A;  3NO9 A;  1Y2M A;  3CZO A;  1TJW A;  1JSW A;  1YFE A;  4BAA A;  2RJS A;  1TJV A;  1DOF A;  1FUP A;  4NLE A;  2VD6 A;  2OHY A;  1W27 A;  3R6Y A;  2PFM A;  1C3U A;  5EYV A;  1J3U A;  1U15 A;  1HY0 A;  4BAB A;  4HGV A;  4FFX A;  3BHG A;  1TJ7 A;  3RD8 A;  4MX2 A;  4C5R A;  2O6Y A;  4V2Q A;  4APB A;  1T6P A;  4ADM A;  3NZ4 A;  5F92 A;  2PTR A;  4V2R A;  1VDK A;  1HY1 A;  4C6G A;  3OCE A;  3QBP A;  3KDZ A;  3GTD A;  1FUO A;  1RE5 A;  3GZH A;  3E04 A;  3TV2 A;  4ADL A;  2QGA B;  2NYN A;  2O78 A;  1GKJ A;  1AUW A;  3OCF A;  1TJU A;  1C3C A;  1K62 A;  4NSL A;  3KDY A;  2O7D A;  5HW2 A; 
#chains in the Genus database with same CATH topology
 1K7W A;  2PTS A;  1XMD A;  2O7F A;  1EB4 A;  2FUS A;  3C8T A;  2YII A;  1T9H A;  1U16 A;  1B8F A;  4L57 A;  2O7E A;  4C5U A;  1GKM A;  2E9F A;  1DCN A;  2PTQ A;  4FLC A;  1T6J A;  2JAO A;  1Z4I A;  4C5S A;  2FEN A;  1XWO A;  4YIK A;  1GK2 A;  1FUR A;  2FEL A;  1Z4J A;  5D6B A;  1GK3 A;  3U13 A;  1KQ7 A;  4L6C A;  4EFC A;  1XMC A;  1Q5N A;  4APA A;  2RCN A;  2O7B A;  5EYT A;  2D27 A;  2J91 A;  1YIS A;  4L6A A;  1IW7 D;  1XLY A;  3U19 A;  3R6V A;  2NYF A;  1FUQ A;  1YFM A;  5F91 A;  4CQ5 A;  3UNV A;  2HVG A;  2QVE A;  1I0A A;  3RRP A;  5H8W A;  2X75 A;  4EEI A;  3R6Q A;  3NO9 A;  1Y2M A;  3CZO A;  1TJW A;  1Q91 A;  1JSW A;  1Z4K A;  1YFE A;  4BAA A;  2RJS A;  1TJV A;  1Z4L A;  1DOF A;  1FUP A;  4MUM A;  4NLE A;  2YV5 A;  3CRV A;  2VD6 A;  4E88 A;  3F4T A;  2OHY A;  5M0J A;  1Z4M A;  4WNL A;  1W27 A;  3R6Y A;  2PFM A;  1U0L A;  1C3U A;  4A15 A;  5EYV A;  1J3U A;  1U15 A;  1HY0 A;  4BAB A;  2RJR A;  5M0I A;  4HGV A;  4FFX A;  2D28 C;  3F4R A;  3BHG A;  2VSF A;  2I7D A;  1TJ7 A;  3F4S A;  2JAU A;  3RD8 A;  1Z4Q A;  4MX2 A;  2O6Y A;  4V2Q A;  4C5R A;  4MWO A;  4APB A;  1T6P A;  4ADM A;  3NZ4 A;  5F92 A;  2PTR A;  4V2R A;  1VDK A;  1HY1 A;  1Z4P X;  1MH9 A;  3OCE A;  4C6G A;  3CRW 1;  3QBP A;  2JAW A;  3BWV A;  3KDZ A;  4NFL A;  3GTD A;  1FUO A;  2JAR A;  1RE5 A;  3GZH A;  2VL7 A;  3E04 A;  3TV2 A;  4ADL A;  1XL7 A;  2QGA B;  1XL8 A;  2NYN A;  2O78 A;  1GKJ A;  1AUW A;  3CI0 K;  3OCF A;  1TJU A;  1C3C A;  1K62 A;  4NSL A;  4IQJ M;  3KDY A;  1Q92 A;  2O7D A;  4YIH A;  5HW2 A; 
#chains in the Genus database with same CATH homology
 1K7W A;  2PTS A;  2O7F A;  1EB4 A;  2FUS A;  3C8T A;  1U16 A;  1B8F A;  2O7E A;  4C5U A;  1GKM A;  2E9F A;  1DCN A;  2PTQ A;  4FLC A;  1T6J A;  4C5S A;  1XWO A;  1GK2 A;  1FUR A;  5D6B A;  1GK3 A;  4EFC A;  1KQ7 A;  2RJR A;  2YII A;  5EYT A;  1Q5N A;  4APA A;  2O7B A;  2J91 A;  1YIS A;  3R6V A;  2NYF A;  1FUQ A;  1YFM A;  5F91 A;  4CQ5 A;  3UNV A;  2HVG A;  2QVE A;  1I0A A;  3RRP A;  2X75 A;  4EEI A;  3R6Q A;  3NO9 A;  1Y2M A;  3CZO A;  1TJW A;  1JSW A;  1YFE A;  4BAA A;  2RJS A;  1TJV A;  1DOF A;  1FUP A;  4NLE A;  2VD6 A;  2OHY A;  1W27 A;  3R6Y A;  2PFM A;  1C3U A;  5EYV A;  1J3U A;  1U15 A;  1HY0 A;  4BAB A;  4HGV A;  4FFX A;  3BHG A;  1TJ7 A;  3RD8 A;  4MX2 A;  4C5R A;  2O6Y A;  4V2Q A;  4APB A;  1T6P A;  4ADM A;  3NZ4 A;  5F92 A;  2PTR A;  4V2R A;  1VDK A;  1HY1 A;  4C6G A;  3OCE A;  3QBP A;  3KDZ A;  3GTD A;  1FUO A;  1RE5 A;  3GZH A;  3E04 A;  3TV2 A;  4ADL A;  2QGA B;  2NYN A;  2O78 A;  1GKJ A;  1AUW A;  3OCF A;  1TJU A;  1C3C A;  1K62 A;  4NSL A;  3KDY A;  2O7D A;  5HW2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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