4APBA

Crystal structure of mycobacterium tuberculosis fumarase (rv1098c) s318c in complex with fumarate
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
sequence length
460
structure length
460
Chain Sequence
NYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGCSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords FUMARATE HYDRATASE CLASS II
publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
total genus 177
structure length 460
sequence length 460
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2012-03-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4apbA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4apbA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4apbA02
2QVEA 1C3UA 1EB4A 5HW2A 2OHYA 1U16A 1J3UA 4EEIA 1YISA 5D6BA 3GZHA 1Q5NA 3OCEA 2O78A 2E9FA 4EFCA 3OCFA 2NYFA 2YIIA 1TJUA 1T6PA 2X75A 4FLCA 4CQ5A 5EYTA 4C6GA 1C3CA 3BHGA 1GKMA 2PTQA 3TV2A 1TJWA 2RJRA 1T6JA 1GKJA 2QGAB 4NLEA 1YFEA 1GK3A 4C5SA 3E04A 3NO9A 4BABA 1FURA 1DCNA 5EYVA 5F91A 2O6YA 1DOFA 3R6QA 4V2RA 1VDKA 4V2QA 4HGVA 1FUOA 2FUSA 2O7FA 3UNVA 4C5RA 2PTRA 1KQ7A 1YFMA 2PTSA 3KDZA 3C8TA 1AUWA 2NYNA 2O7DA 4C5UA 1I0AA 1W27A 4ADMA 2PFMA 2O7BA 3GTDA 3KDYA 1K62A 1K7WA 2HVGA 4APBA 1FUQA 1HY0A 1B8FA 1GK2A 3CZOA 3R6YA 1FUPA 4MX2A 3QBPA 3R6VA 4FFXA 5F92A 4ADLA 1U15A 1XWOA 4BAAA 1RE5A 4NSLA 3RRPA 3NZ4A 1JSWA 1HY1A 2RJSA 4APAA 1Y2MA 3RD8A 1TJVA 2J91A 1TJ7A 2O7EA 2VD6A
chains in the Genus database with same CATH superfamily
5H8WA 2QVEA 2VSFA 1C3UA 1EB4A 4L6CA 5HW2A 2OHYA 1U16A 2O7EA 1J3UA 4EEIA 1YISA 1Z4KA 5D6BA 3GZHA 1Z4JA 1Q5NA 3OCEA 2O78A 2RCNA 5M0JA 2E9FA 4EFCA 4IQJM 3OCFA 1XL8A 2NYFA 4NFLA 2YIIA 1TJUA 1T6PA 2X75A 4FLCA 4CQ5A 5EYTA 4C6GA 1C3CA 3BHGA 1GKMA 2PTQA 2I7DA 3TV2A 1TJWA 4E88A 2D28C 1T6JA 2RJRA 1GKJA 2QGAB 4NLEA 1YFEA 2JAWA 1GK3A 1Q92A 4C5SA 3E04A 3NO9A 2YV5A 4BABA 1FURA 1DCNA 3U19A 1XMCA 3U13A 4MUMA 5EYVA 5F91A 2O6YA 3CRW1 1DOFA 4MWOA 3R6QA 4V2RA 1IW7D 1MH9A 1VDKA 4V2QA 1XMDA 4HGVA 1Z4MA 1FUOA 3CI0K 2FUSA 2O7FA 3UNVA 4C5RA 2PTRA 1KQ7A 1YFMA 2PTSA 4A15A 3KDZA 1Z4PX 3C8TA 1AUWA 2NYNA 2O7DA 4C5UA 2VL7A 1Z4LA 4YIKA 1T9HA 1I0AA 3CRVA 1W27A 2JAOA 2PFMA 4ADMA 2O7BA 3GTDA 3KDYA 1K62A 3F4TA 1K7WA 2HVGA 4APBA 2FENA 1U0LA 1Z4IA 1FUQA 1HY0A 1XLYA 1B8FA 1XL7A 1GK2A 3CZOA 3R6YA 4L57A 1FUPA 4MX2A 4YIHA 3QBPA 3R6VA 4FFXA 5F92A 1Q91A 2JARA 4ADLA 1U15A 1XWOA 4BAAA 1RE5A 3F4RA 4NSLA 3RRPA 2JAUA 3NZ4A 1JSWA 1HY1A 2RJSA 4WNLA 3F4SA 4L6AA 4APAA 1Y2MA 1Z4QA 2FELA 3BWVA 3RD8A 1TJVA 2J91A 5M0IA 1TJ7A 2D27A 2VD6A
chains in the Genus database with same CATH topology
2QVEA 1C3UA 1EB4A 5HW2A 2OHYA 1U16A 1J3UA 4EEIA 1YISA 5D6BA 3GZHA 1Q5NA 3OCEA 2O78A 2E9FA 4EFCA 3OCFA 2NYFA 2YIIA 1TJUA 1T6PA 2X75A 4FLCA 4CQ5A 5EYTA 4C6GA 1C3CA 3BHGA 1GKMA 2PTQA 3TV2A 1TJWA 2RJRA 1T6JA 1GKJA 2QGAB 4NLEA 1YFEA 1GK3A 4C5SA 3E04A 3NO9A 4BABA 1FURA 1DCNA 5EYVA 5F91A 2O6YA 1DOFA 3R6QA 4V2RA 1VDKA 4V2QA 4HGVA 1FUOA 2FUSA 2O7FA 3UNVA 4C5RA 2PTRA 1KQ7A 1YFMA 2PTSA 3KDZA 3C8TA 1AUWA 2NYNA 2O7DA 4C5UA 1I0AA 1W27A 4ADMA 2PFMA 2O7BA 3GTDA 3KDYA 1K62A 1K7WA 2HVGA 4APBA 1FUQA 1HY0A 1B8FA 1GK2A 3CZOA 3R6YA 1FUPA 4MX2A 3QBPA 3R6VA 4FFXA 5F92A 4ADLA 1U15A 1XWOA 4BAAA 1RE5A 4NSLA 3RRPA 3NZ4A 1JSWA 1HY1A 2RJSA 4APAA 1Y2MA 3RD8A 1TJVA 2J91A 1TJ7A 2O7EA 2VD6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2QVE A;  1C3U A;  1EB4 A;  5HW2 A;  2OHY A;  1U16 A;  1J3U A;  4EEI A;  1YIS A;  5D6B A;  3GZH A;  1Q5N A;  3OCE A;  2O78 A;  2E9F A;  4EFC A;  3OCF A;  2NYF A;  2YII A;  1TJU A;  1T6P A;  2X75 A;  4FLC A;  4CQ5 A;  5EYT A;  4C6G A;  1C3C A;  3BHG A;  1GKM A;  2PTQ A;  3TV2 A;  1TJW A;  2RJR A;  1T6J A;  1GKJ A;  2QGA B;  4NLE A;  1YFE A;  1GK3 A;  4C5S A;  3E04 A;  3NO9 A;  4BAB A;  1FUR A;  1DCN A;  5EYV A;  5F91 A;  2O6Y A;  1DOF A;  3R6Q A;  4V2R A;  1VDK A;  4V2Q A;  4HGV A;  1FUO A;  2FUS A;  2O7F A;  3UNV A;  4C5R A;  2PTR A;  1KQ7 A;  1YFM A;  2PTS A;  3KDZ A;  3C8T A;  1AUW A;  2NYN A;  2O7D A;  4C5U A;  1I0A A;  1W27 A;  4ADM A;  2PFM A;  2O7B A;  3GTD A;  3KDY A;  1K62 A;  1K7W A;  2HVG A;  4APB A;  1FUQ A;  1HY0 A;  1B8F A;  1GK2 A;  3CZO A;  3R6Y A;  1FUP A;  4MX2 A;  3QBP A;  3R6V A;  4FFX A;  5F92 A;  4ADL A;  1U15 A;  1XWO A;  4BAA A;  1RE5 A;  4NSL A;  3RRP A;  3NZ4 A;  1JSW A;  1HY1 A;  2RJS A;  4APA A;  1Y2M A;  3RD8 A;  1TJV A;  2J91 A;  1TJ7 A;  2O7E A;  2VD6 A; 
#chains in the Genus database with same CATH topology
 5H8W A;  2QVE A;  2VSF A;  1C3U A;  1EB4 A;  4L6C A;  5HW2 A;  2OHY A;  1U16 A;  2O7E A;  1J3U A;  4EEI A;  1YIS A;  1Z4K A;  5D6B A;  3GZH A;  1Z4J A;  1Q5N A;  3OCE A;  2O78 A;  2RCN A;  5M0J A;  2E9F A;  4EFC A;  4IQJ M;  3OCF A;  1XL8 A;  2NYF A;  4NFL A;  2YII A;  1TJU A;  1T6P A;  2X75 A;  4FLC A;  4CQ5 A;  5EYT A;  4C6G A;  1C3C A;  3BHG A;  1GKM A;  2PTQ A;  2I7D A;  3TV2 A;  1TJW A;  4E88 A;  2D28 C;  1T6J A;  2RJR A;  1GKJ A;  2QGA B;  4NLE A;  1YFE A;  2JAW A;  1GK3 A;  1Q92 A;  4C5S A;  3E04 A;  3NO9 A;  2YV5 A;  4BAB A;  1FUR A;  1DCN A;  3U19 A;  1XMC A;  3U13 A;  4MUM A;  5EYV A;  5F91 A;  2O6Y A;  3CRW 1;  1DOF A;  4MWO A;  3R6Q A;  4V2R A;  1IW7 D;  1MH9 A;  1VDK A;  4V2Q A;  1XMD A;  4HGV A;  1Z4M A;  1FUO A;  3CI0 K;  2FUS A;  2O7F A;  3UNV A;  4C5R A;  2PTR A;  1KQ7 A;  1YFM A;  2PTS A;  4A15 A;  3KDZ A;  1Z4P X;  3C8T A;  1AUW A;  2NYN A;  2O7D A;  4C5U A;  2VL7 A;  1Z4L A;  4YIK A;  1T9H A;  1I0A A;  3CRV A;  1W27 A;  2JAO A;  2PFM A;  4ADM A;  2O7B A;  3GTD A;  3KDY A;  1K62 A;  3F4T A;  1K7W A;  2HVG A;  4APB A;  2FEN A;  1U0L A;  1Z4I A;  1FUQ A;  1HY0 A;  1XLY A;  1B8F A;  1XL7 A;  1GK2 A;  3CZO A;  3R6Y A;  4L57 A;  1FUP A;  4MX2 A;  4YIH A;  3QBP A;  3R6V A;  4FFX A;  5F92 A;  1Q91 A;  2JAR A;  4ADL A;  1U15 A;  1XWO A;  4BAA A;  1RE5 A;  3F4R A;  4NSL A;  3RRP A;  2JAU A;  3NZ4 A;  1JSW A;  1HY1 A;  2RJS A;  4WNL A;  3F4S A;  4L6A A;  4APA A;  1Y2M A;  1Z4Q A;  2FEL A;  3BWV A;  3RD8 A;  1TJV A;  2J91 A;  5M0I A;  1TJ7 A;  2D27 A;  2VD6 A; 
#chains in the Genus database with same CATH homology
 2QVE A;  1C3U A;  1EB4 A;  5HW2 A;  2OHY A;  1U16 A;  1J3U A;  4EEI A;  1YIS A;  5D6B A;  3GZH A;  1Q5N A;  3OCE A;  2O78 A;  2E9F A;  4EFC A;  3OCF A;  2NYF A;  2YII A;  1TJU A;  1T6P A;  2X75 A;  4FLC A;  4CQ5 A;  5EYT A;  4C6G A;  1C3C A;  3BHG A;  1GKM A;  2PTQ A;  3TV2 A;  1TJW A;  2RJR A;  1T6J A;  1GKJ A;  2QGA B;  4NLE A;  1YFE A;  1GK3 A;  4C5S A;  3E04 A;  3NO9 A;  4BAB A;  1FUR A;  1DCN A;  5EYV A;  5F91 A;  2O6Y A;  1DOF A;  3R6Q A;  4V2R A;  1VDK A;  4V2Q A;  4HGV A;  1FUO A;  2FUS A;  2O7F A;  3UNV A;  4C5R A;  2PTR A;  1KQ7 A;  1YFM A;  2PTS A;  3KDZ A;  3C8T A;  1AUW A;  2NYN A;  2O7D A;  4C5U A;  1I0A A;  1W27 A;  4ADM A;  2PFM A;  2O7B A;  3GTD A;  3KDY A;  1K62 A;  1K7W A;  2HVG A;  4APB A;  1FUQ A;  1HY0 A;  1B8F A;  1GK2 A;  3CZO A;  3R6Y A;  1FUP A;  4MX2 A;  3QBP A;  3R6V A;  4FFX A;  5F92 A;  4ADL A;  1U15 A;  1XWO A;  4BAA A;  1RE5 A;  4NSL A;  3RRP A;  3NZ4 A;  1JSW A;  1HY1 A;  2RJS A;  4APA A;  1Y2M A;  3RD8 A;  1TJV A;  2J91 A;  1TJ7 A;  2O7E A;  2VD6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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