2RJSA

Sgtam bound to substrate mimic
Total Genus 198
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
198
sequence length
526
structure length
525
Chain Sequence
PVSVDGETLTVEAVRRVAEERATVDVPAESIAKAQKSREIFEGIAEQNIPIYGVTTGYGEMIYMQVDKSKEVELQTNLVRSHSAGVGPLFAEDEARAIVAARLNTLAKGHSAVRPIILERLAQYLNEGITPAIPEIGSLGDLAPLSHVASTLIGEGYVLRDGRPVETAQVLAERGIEPLELRFKEGLALINGTSGMTGLGSLVVGRALEQAQQAEIVTALLIEAVRGSTSPFLAEGHDIARPHEGQIDTAANMRALMRGSGLTVEHADLRRELQKDKEAGKDVQRSEIYLQKAYSLRAIPQVVGAVRDTLYHARHKLRIELNSANDNPLFFEGKEIFHGANFHGQPIAFAMDFVTIALTQLGVLAERQINRVLNRHLSYGLPEFLVSGDPGLHSGFAGAQYPATALVAENRTIGPASTQSVPSNGDNQDVVSMGLISARNARRVLSNNNKILAVEYLAAAQAVDISGRFDGLSPAAKATYEAVRRLVPTLGVDRYMADDIELVADALSRGEFLRAIARETDIQLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Isomerase
molecule keywords Tyrosine aminomutase
publication title Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM.
pubmed doi rcsb
source organism Streptomyces globisporus
total genus 198
structure length 525
sequence length 526
chains with identical sequence B
ec nomenclature ec 4.3.1.23: Tyrosine ammonia-lyase.
pdb deposition date 2007-10-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2rjsA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2rjsA02
1TJ7A 2NYNA 1YISA 1K7WA 1C3CA 1C3UA 1YFEA 1TJVA 4EFCA 1FURA 2VD6A 1TJWA 2O6YA 3E04A 2PTSA 1HY0A 1RE5A 2O7BA 3CZOA 3KDZA 4MX2A 1FUQA 1K62A 5F91A 2PTQA 1DCNA 2QGAB 5HW2A 4HGVA 4V2QA 1DOFA 2O7FA 3C8TA 3RRPA 2PTRA 4C5UA 4C5RA 4BABA 1W27A 2O78A 1EB4A 1T6JA 1T6PA 2QVEA 5EYVA 3UNVA 2RJSA 4C6GA 1FUPA 1U16A 3R6QA 3GZHA 4EEIA 2J91A 3NO9A 2E9FA 4APAA 1GKMA 3OCFA 3R6VA 1B8FA 1GKJA 1VDKA 2YIIA 5F92A 1AUWA 4ADMA 2O7DA 4NSLA 1Y2MA 4C5SA 4FFXA 1FUOA 3KDYA 3BHGA 2X75A 1KQ7A 2O7EA 1I0AA 3TV2A 4FLCA 4V2RA 1YFMA 4BAAA 2OHYA 4NLEA 5D6BA 1GK2A 3NZ4A 4APBA 1JSWA 1TJUA 5EYTA 4ADLA 3GTDA 3RD8A 3R6YA 1GK3A 2RJRA 1U15A 3QBPA 2HVGA 1J3UA 2NYFA 2FUSA 1HY1A 2PFMA 1XWOA 1Q5NA 4CQ5A 3OCEA
chains in the Genus database with same CATH superfamily
1TJ7A 2NYNA 1YISA 1K7WA 1C3CA 2VL7A 1C3UA 1YFEA 1TJVA 4EFCA 1FURA 2VD6A 1TJWA 2O6YA 3E04A 2PTSA 1HY0A 1RE5A 2O7BA 3CZOA 3KDZA 4MX2A 1FUQA 1K62A 5F91A 2PTQA 2FELA 1DCNA 2QGAB 5HW2A 1XMDA 3CRVA 4HGVA 4V2QA 1DOFA 2O7FA 3C8TA 1XL8A 2VSFA 3RRPA 1XL7A 2PTRA 4C5UA 4C5RA 4BABA 1W27A 2O78A 1EB4A 1T6JA 1T6PA 2QVEA 5EYVA 3UNVA 2RJSA 4C6GA 1FUPA 1U16A 3R6QA 3GZHA 4A15A 4EEIA 2J91A 3NO9A 4WNLA 2E9FA 4APAA 1GKMA 5M0JA 3OCFA 5H8WA 3R6VA 1B8FA 1GKJA 1VDKA 2YIIA 5F92A 1AUWA 4ADMA 2O7DA 4NSLA 1Y2MA 4C5SA 4FFXA 1FUOA 3KDYA 3BHGA 2X75A 1KQ7A 2O7EA 1I0AA 3TV2A 4FLCA 4V2RA 1YFMA 4BAAA 2OHYA 4NLEA 5D6BA 1GK2A 2FENA 3NZ4A 4APBA 1JSWA 1TJUA 5EYTA 4ADLA 3CRW1 3GTDA 1XLYA 5M0IA 3RD8A 3R6YA 1GK3A 2RJRA 1U15A 3QBPA 2HVGA 1J3UA 2NYFA 1XMCA 2FUSA 1HY1A 2PFMA 1XWOA 1Q5NA 4CQ5A 3OCEA
chains in the Genus database with same CATH topology
1TJ7A 2NYNA 1YISA 1K7WA 1C3CA 1C3UA 1YFEA 1TJVA 4EFCA 1FURA 2VD6A 1TJWA 2O6YA 3E04A 2PTSA 1HY0A 1RE5A 2O7BA 3CZOA 3KDZA 4MX2A 1FUQA 1K62A 5F91A 2PTQA 1DCNA 2QGAB 5HW2A 4HGVA 4V2QA 1DOFA 2O7FA 3C8TA 3RRPA 2PTRA 4C5UA 4C5RA 4BABA 1W27A 2O78A 1EB4A 1T6JA 1T6PA 2QVEA 5EYVA 3UNVA 2RJSA 4C6GA 1FUPA 1U16A 3R6QA 3GZHA 4EEIA 2J91A 3NO9A 2E9FA 4APAA 1GKMA 3OCFA 3R6VA 1B8FA 1GKJA 1VDKA 2YIIA 5F92A 1AUWA 4ADMA 2O7DA 4NSLA 1Y2MA 4C5SA 4FFXA 1FUOA 3KDYA 3BHGA 2X75A 1KQ7A 2O7EA 1I0AA 3TV2A 4FLCA 4V2RA 1YFMA 4BAAA 2OHYA 4NLEA 5D6BA 1GK2A 3NZ4A 4APBA 1JSWA 1TJUA 5EYTA 4ADLA 3GTDA 3RD8A 3R6YA 1GK3A 2RJRA 1U15A 3QBPA 2HVGA 1J3UA 2NYFA 2FUSA 1HY1A 2PFMA 1XWOA 1Q5NA 4CQ5A 3OCEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TJ7 A;  2NYN A;  1YIS A;  1K7W A;  1C3C A;  1C3U A;  1YFE A;  1TJV A;  4EFC A;  1FUR A;  2VD6 A;  1TJW A;  2O6Y A;  3E04 A;  2PTS A;  1HY0 A;  1RE5 A;  2O7B A;  3CZO A;  3KDZ A;  4MX2 A;  1FUQ A;  1K62 A;  5F91 A;  2PTQ A;  1DCN A;  2QGA B;  5HW2 A;  4HGV A;  4V2Q A;  1DOF A;  2O7F A;  3C8T A;  3RRP A;  2PTR A;  4C5U A;  4C5R A;  4BAB A;  1W27 A;  2O78 A;  1EB4 A;  1T6J A;  1T6P A;  2QVE A;  5EYV A;  3UNV A;  2RJS A;  4C6G A;  1FUP A;  1U16 A;  3R6Q A;  3GZH A;  4EEI A;  2J91 A;  3NO9 A;  2E9F A;  4APA A;  1GKM A;  3OCF A;  3R6V A;  1B8F A;  1GKJ A;  1VDK A;  2YII A;  5F92 A;  1AUW A;  4ADM A;  2O7D A;  4NSL A;  1Y2M A;  4C5S A;  4FFX A;  1FUO A;  3KDY A;  3BHG A;  2X75 A;  1KQ7 A;  2O7E A;  1I0A A;  3TV2 A;  4FLC A;  4V2R A;  1YFM A;  4BAA A;  2OHY A;  4NLE A;  5D6B A;  1GK2 A;  3NZ4 A;  4APB A;  1JSW A;  1TJU A;  5EYT A;  4ADL A;  3GTD A;  3RD8 A;  3R6Y A;  1GK3 A;  2RJR A;  1U15 A;  3QBP A;  2HVG A;  1J3U A;  2NYF A;  2FUS A;  1HY1 A;  2PFM A;  1XWO A;  1Q5N A;  4CQ5 A;  3OCE A; 
#chains in the Genus database with same CATH topology
 1TJ7 A;  2NYN A;  1YIS A;  1K7W A;  1C3C A;  2VL7 A;  1C3U A;  1YFE A;  1TJV A;  4EFC A;  1FUR A;  2VD6 A;  1TJW A;  2O6Y A;  3E04 A;  2PTS A;  1HY0 A;  1RE5 A;  2O7B A;  3CZO A;  3KDZ A;  4MX2 A;  1FUQ A;  1K62 A;  5F91 A;  2PTQ A;  2FEL A;  1DCN A;  2QGA B;  5HW2 A;  1XMD A;  3CRV A;  4HGV A;  4V2Q A;  1DOF A;  2O7F A;  3C8T A;  1XL8 A;  2VSF A;  3RRP A;  1XL7 A;  2PTR A;  4C5U A;  4C5R A;  4BAB A;  1W27 A;  2O78 A;  1EB4 A;  1T6J A;  1T6P A;  2QVE A;  5EYV A;  3UNV A;  2RJS A;  4C6G A;  1FUP A;  1U16 A;  3R6Q A;  3GZH A;  4A15 A;  4EEI A;  2J91 A;  3NO9 A;  4WNL A;  2E9F A;  4APA A;  1GKM A;  5M0J A;  3OCF A;  5H8W A;  3R6V A;  1B8F A;  1GKJ A;  1VDK A;  2YII A;  5F92 A;  1AUW A;  4ADM A;  2O7D A;  4NSL A;  1Y2M A;  4C5S A;  4FFX A;  1FUO A;  3KDY A;  3BHG A;  2X75 A;  1KQ7 A;  2O7E A;  1I0A A;  3TV2 A;  4FLC A;  4V2R A;  1YFM A;  4BAA A;  2OHY A;  4NLE A;  5D6B A;  1GK2 A;  2FEN A;  3NZ4 A;  4APB A;  1JSW A;  1TJU A;  5EYT A;  4ADL A;  3CRW 1;  3GTD A;  1XLY A;  5M0I A;  3RD8 A;  3R6Y A;  1GK3 A;  2RJR A;  1U15 A;  3QBP A;  2HVG A;  1J3U A;  2NYF A;  1XMC A;  2FUS A;  1HY1 A;  2PFM A;  1XWO A;  1Q5N A;  4CQ5 A;  3OCE A; 
#chains in the Genus database with same CATH homology
 1TJ7 A;  2NYN A;  1YIS A;  1K7W A;  1C3C A;  1C3U A;  1YFE A;  1TJV A;  4EFC A;  1FUR A;  2VD6 A;  1TJW A;  2O6Y A;  3E04 A;  2PTS A;  1HY0 A;  1RE5 A;  2O7B A;  3CZO A;  3KDZ A;  4MX2 A;  1FUQ A;  1K62 A;  5F91 A;  2PTQ A;  1DCN A;  2QGA B;  5HW2 A;  4HGV A;  4V2Q A;  1DOF A;  2O7F A;  3C8T A;  3RRP A;  2PTR A;  4C5U A;  4C5R A;  4BAB A;  1W27 A;  2O78 A;  1EB4 A;  1T6J A;  1T6P A;  2QVE A;  5EYV A;  3UNV A;  2RJS A;  4C6G A;  1FUP A;  1U16 A;  3R6Q A;  3GZH A;  4EEI A;  2J91 A;  3NO9 A;  2E9F A;  4APA A;  1GKM A;  3OCF A;  3R6V A;  1B8F A;  1GKJ A;  1VDK A;  2YII A;  5F92 A;  1AUW A;  4ADM A;  2O7D A;  4NSL A;  1Y2M A;  4C5S A;  4FFX A;  1FUO A;  3KDY A;  3BHG A;  2X75 A;  1KQ7 A;  2O7E A;  1I0A A;  3TV2 A;  4FLC A;  4V2R A;  1YFM A;  4BAA A;  2OHY A;  4NLE A;  5D6B A;  1GK2 A;  3NZ4 A;  4APB A;  1JSW A;  1TJU A;  5EYT A;  4ADL A;  3GTD A;  3RD8 A;  3R6Y A;  1GK3 A;  2RJR A;  1U15 A;  3QBP A;  2HVG A;  1J3U A;  2NYF A;  2FUS A;  1HY1 A;  2PFM A;  1XWO A;  1Q5N A;  4CQ5 A;  3OCE A; 
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