2O7DA

Tyrosine ammonia-lyase from rhodobacter sphaeroides, complexed with caffeate
Total Genus 193
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
193
sequence length
515
structure length
514
Chain Sequence
PKPAVELDRHIDLDQAHAVASGGARIVLAPPARDRCRASEARLGAVIREARHVYGLTTGFGPLANRLISGENVRTLQANLVHHLASGVGPVLDWTTARAMVLARLVSIAQGASGASEGTIARLIDLLNSELAPAVPSRGTVGDLTPLAHMVLCLQGRGDFLDRDGTRLDGAEGLRRGRLQPLDLSHRDALALVNGTSAMTGIALVNAHACRHLGNWAVALTALLAECLRGRTEAWAAALSDLRPHPGQKDAAARLRARVDGSARVVRHVIAERRLDAGDIGTEPEAGQDAYSLRCAPQVLGAGFDTLAWHDRVLTIELNAVTDNPVFPPDGSVPALHGGNFMGQHVALTSDALATAVTVLAGLAERQIARLTDERLNRGLPPFLHRGPAGLNSGFMGAQVTATALLAEMRATGPASIHSISTNAANQDVVSLGTIAARLCREKIDRWAEILAILALCLAQAAELRCGSGLDGVSPAGKKLVQALREQFPPLETDRPLGQEIAALATHLLQQSPV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule keywords Putative histidine ammonia-lyase
publication title Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases.
pubmed doi rcsb
source organism Rhodobacter sphaeroides
molecule tags Lyase
total genus 193
structure length 514
sequence length 515
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 4.3.1.23: Tyrosine ammonia-lyase.
pdb deposition date 2006-12-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 2o7dA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 2o7dA02
2O7FA 4FLCA 1B8FA 1TJUA 1FURA 1RE5A 3BHGA 2X75A 4C5UA 4CQ5A 1AUWA 1GK3A 1EB4A 3R6VA 4BABA 1DOFA 1GKJA 4V2RA 5EYTA 2HVGA 3OCEA 4ADLA 3TV2A 1T6JA 3CZOA 3GZHA 3OCFA 2PTRA 2O78A 1Y2MA 3UNVA 1Q5NA 1TJVA 5EYVA 2E9FA 3RRPA 2PFMA 1C3CA 1XWOA 2YIIA 3E04A 1FUQA 1K62A 3KDYA 2NYNA 4ADMA 4BAAA 4NSLA 4EEIA 4C5RA 2J91A 1YISA 1KQ7A 1FUOA 4APBA 5F92A 1HY1A 5F91A 3GTDA 1K7WA 2PTSA 1DCNA 2RJRA 3QBPA 5D6BA 3C8TA 5HW2A 2QVEA 3NO9A 1C3UA 1I0AA 2QGAB 3RD8A 4APAA 2O7BA 2O7EA 1FUPA 3NZ4A 1U15A 2RJSA 2VD6A 2FUSA 2OHYA 4V2QA 1W27A 1GK2A 4EFCA 4NLEA 1T6PA 1TJWA 1U16A 1YFEA 4C5SA 4HGVA 1J3UA 1HY0A 2NYFA 2O6YA 1YFMA 3R6QA 4MX2A 1JSWA 4FFXA 2PTQA 3R6YA 1VDKA 1TJ7A 3KDZA 1GKMA 4C6GA 2O7DA
chains in the Genus database with same CATH superfamily
2O7FA 4FLCA 1B8FA 1TJUA 1FURA 1RE5A 3BHGA 2X75A 1XMCA 1XL7A 4C5UA 4CQ5A 5M0IA 1AUWA 1GK3A 1EB4A 4A15A 3R6VA 3CRVA 4BABA 1DOFA 1GKJA 4V2RA 5EYTA 2HVGA 3OCEA 4ADLA 2FELA 3TV2A 1T6JA 3CZOA 3GZHA 3OCFA 2PTRA 2O78A 1Y2MA 3UNVA 1XLYA 1Q5NA 1TJVA 2FENA 2E9FA 5EYVA 3RRPA 2VSFA 2PFMA 1C3CA 1XWOA 2YIIA 3E04A 1FUQA 1K62A 3KDYA 2NYNA 4ADMA 4BAAA 1XL8A 4NSLA 4EEIA 4C5RA 2J91A 4WNLA 1YISA 1KQ7A 1FUOA 4APBA 3CRW1 5F92A 1HY1A 1XMDA 5F91A 3GTDA 1K7WA 2PTSA 1DCNA 2RJRA 3QBPA 5D6BA 3C8TA 5HW2A 2QVEA 3NO9A 1C3UA 1I0AA 2QGAB 5M0JA 3RD8A 4APAA 2O7BA 2O7EA 1FUPA 3NZ4A 1U15A 5H8WA 2RJSA 2VD6A 2VL7A 2FUSA 2OHYA 4V2QA 1W27A 1GK2A 4EFCA 4NLEA 1T6PA 1TJWA 1U16A 1YFEA 4C5SA 4HGVA 1J3UA 1HY0A 2NYFA 2O6YA 1YFMA 3R6QA 4MX2A 1JSWA 4FFXA 2PTQA 3R6YA 1VDKA 1TJ7A 3KDZA 1GKMA 4C6GA 2O7DA
chains in the Genus database with same CATH topology
2O7FA 4FLCA 1B8FA 1TJUA 1FURA 1RE5A 3BHGA 2X75A 4C5UA 4CQ5A 1AUWA 1GK3A 1EB4A 3R6VA 4BABA 1DOFA 1GKJA 4V2RA 5EYTA 2HVGA 3OCEA 4ADLA 3TV2A 1T6JA 3CZOA 3GZHA 3OCFA 2PTRA 2O78A 1Y2MA 3UNVA 1Q5NA 1TJVA 5EYVA 2E9FA 3RRPA 2PFMA 1C3CA 1XWOA 2YIIA 3E04A 1FUQA 1K62A 3KDYA 2NYNA 4ADMA 4BAAA 4NSLA 4EEIA 4C5RA 2J91A 1YISA 1KQ7A 1FUOA 4APBA 5F92A 1HY1A 5F91A 3GTDA 1K7WA 2PTSA 1DCNA 2RJRA 3QBPA 5D6BA 3C8TA 5HW2A 2QVEA 3NO9A 1C3UA 1I0AA 2QGAB 3RD8A 4APAA 2O7BA 2O7EA 1FUPA 3NZ4A 1U15A 2RJSA 2VD6A 2FUSA 2OHYA 4V2QA 1W27A 1GK2A 4EFCA 4NLEA 1T6PA 1TJWA 1U16A 1YFEA 4C5SA 4HGVA 1J3UA 1HY0A 2NYFA 2O6YA 1YFMA 3R6QA 4MX2A 1JSWA 4FFXA 2PTQA 3R6YA 1VDKA 1TJ7A 3KDZA 1GKMA 4C6GA 2O7DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2O7F A;  4FLC A;  1B8F A;  1TJU A;  1FUR A;  1RE5 A;  3BHG A;  2X75 A;  4C5U A;  4CQ5 A;  1AUW A;  1GK3 A;  1EB4 A;  3R6V A;  4BAB A;  1DOF A;  1GKJ A;  4V2R A;  5EYT A;  2HVG A;  3OCE A;  4ADL A;  3TV2 A;  1T6J A;  3CZO A;  3GZH A;  3OCF A;  2PTR A;  2O78 A;  1Y2M A;  3UNV A;  1Q5N A;  1TJV A;  5EYV A;  2E9F A;  3RRP A;  2PFM A;  1C3C A;  1XWO A;  2YII A;  3E04 A;  1FUQ A;  1K62 A;  3KDY A;  2NYN A;  4ADM A;  4BAA A;  4NSL A;  4EEI A;  4C5R A;  2J91 A;  1YIS A;  1KQ7 A;  1FUO A;  4APB A;  5F92 A;  1HY1 A;  5F91 A;  3GTD A;  1K7W A;  2PTS A;  1DCN A;  2RJR A;  3QBP A;  5D6B A;  3C8T A;  5HW2 A;  2QVE A;  3NO9 A;  1C3U A;  1I0A A;  2QGA B;  3RD8 A;  4APA A;  2O7B A;  2O7E A;  1FUP A;  3NZ4 A;  1U15 A;  2RJS A;  2VD6 A;  2FUS A;  2OHY A;  4V2Q A;  1W27 A;  1GK2 A;  4EFC A;  4NLE A;  1T6P A;  1TJW A;  1U16 A;  1YFE A;  4C5S A;  4HGV A;  1J3U A;  1HY0 A;  2NYF A;  2O6Y A;  1YFM A;  3R6Q A;  4MX2 A;  1JSW A;  4FFX A;  2PTQ A;  3R6Y A;  1VDK A;  1TJ7 A;  3KDZ A;  1GKM A;  4C6G A;  2O7D A; 
#chains in the Genus database with same CATH topology
 2O7F A;  4FLC A;  1B8F A;  1TJU A;  1FUR A;  1RE5 A;  3BHG A;  2X75 A;  1XMC A;  1XL7 A;  4C5U A;  4CQ5 A;  5M0I A;  1AUW A;  1GK3 A;  1EB4 A;  4A15 A;  3R6V A;  3CRV A;  4BAB A;  1DOF A;  1GKJ A;  4V2R A;  5EYT A;  2HVG A;  3OCE A;  4ADL A;  2FEL A;  3TV2 A;  1T6J A;  3CZO A;  3GZH A;  3OCF A;  2PTR A;  2O78 A;  1Y2M A;  3UNV A;  1XLY A;  1Q5N A;  1TJV A;  2FEN A;  2E9F A;  5EYV A;  3RRP A;  2VSF A;  2PFM A;  1C3C A;  1XWO A;  2YII A;  3E04 A;  1FUQ A;  1K62 A;  3KDY A;  2NYN A;  4ADM A;  4BAA A;  1XL8 A;  4NSL A;  4EEI A;  4C5R A;  2J91 A;  4WNL A;  1YIS A;  1KQ7 A;  1FUO A;  4APB A;  3CRW 1;  5F92 A;  1HY1 A;  1XMD A;  5F91 A;  3GTD A;  1K7W A;  2PTS A;  1DCN A;  2RJR A;  3QBP A;  5D6B A;  3C8T A;  5HW2 A;  2QVE A;  3NO9 A;  1C3U A;  1I0A A;  2QGA B;  5M0J A;  3RD8 A;  4APA A;  2O7B A;  2O7E A;  1FUP A;  3NZ4 A;  1U15 A;  5H8W A;  2RJS A;  2VD6 A;  2VL7 A;  2FUS A;  2OHY A;  4V2Q A;  1W27 A;  1GK2 A;  4EFC A;  4NLE A;  1T6P A;  1TJW A;  1U16 A;  1YFE A;  4C5S A;  4HGV A;  1J3U A;  1HY0 A;  2NYF A;  2O6Y A;  1YFM A;  3R6Q A;  4MX2 A;  1JSW A;  4FFX A;  2PTQ A;  3R6Y A;  1VDK A;  1TJ7 A;  3KDZ A;  1GKM A;  4C6G A;  2O7D A; 
#chains in the Genus database with same CATH homology
 2O7F A;  4FLC A;  1B8F A;  1TJU A;  1FUR A;  1RE5 A;  3BHG A;  2X75 A;  4C5U A;  4CQ5 A;  1AUW A;  1GK3 A;  1EB4 A;  3R6V A;  4BAB A;  1DOF A;  1GKJ A;  4V2R A;  5EYT A;  2HVG A;  3OCE A;  4ADL A;  3TV2 A;  1T6J A;  3CZO A;  3GZH A;  3OCF A;  2PTR A;  2O78 A;  1Y2M A;  3UNV A;  1Q5N A;  1TJV A;  5EYV A;  2E9F A;  3RRP A;  2PFM A;  1C3C A;  1XWO A;  2YII A;  3E04 A;  1FUQ A;  1K62 A;  3KDY A;  2NYN A;  4ADM A;  4BAA A;  4NSL A;  4EEI A;  4C5R A;  2J91 A;  1YIS A;  1KQ7 A;  1FUO A;  4APB A;  5F92 A;  1HY1 A;  5F91 A;  3GTD A;  1K7W A;  2PTS A;  1DCN A;  2RJR A;  3QBP A;  5D6B A;  3C8T A;  5HW2 A;  2QVE A;  3NO9 A;  1C3U A;  1I0A A;  2QGA B;  3RD8 A;  4APA A;  2O7B A;  2O7E A;  1FUP A;  3NZ4 A;  1U15 A;  2RJS A;  2VD6 A;  2FUS A;  2OHY A;  4V2Q A;  1W27 A;  1GK2 A;  4EFC A;  4NLE A;  1T6P A;  1TJW A;  1U16 A;  1YFE A;  4C5S A;  4HGV A;  1J3U A;  1HY0 A;  2NYF A;  2O6Y A;  1YFM A;  3R6Q A;  4MX2 A;  1JSW A;  4FFX A;  2PTQ A;  3R6Y A;  1VDK A;  1TJ7 A;  3KDZ A;  1GKM A;  4C6G A;  2O7D A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...