5F91A

Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator (n-(5-(azepan-1-ylsulfonyl)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide)
Total Genus 176
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
176
sequence length
459
structure length
447
Chain Sequence
NYRIEHEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lyase/lyase inhibitor
molecule keywords Fumarate hydratase class II
publication title Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
pubmed doi rcsb
source organism Mycobacterium tuberculosis (strain cdc 1551 / oshkosh)
total genus 176
structure length 447
sequence length 459
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2015-12-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 5f91A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 5f91A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 5f91A02
2NYFA 2PTQA 1DCNA 4HGVA 4C5SA 3R6QA 3OCEA 3CZOA 1W27A 2VD6A 2RJSA 3NO9A 1XWOA 1T6PA 2PFMA 1U16A 1Y2MA 4APBA 1K7WA 1TJUA 1FUOA 2O7EA 2J91A 4APAA 3E04A 3OCFA 4NSLA 4ADMA 1TJVA 2OHYA 2YIIA 5F91A 2QGAB 1JSWA 5HW2A 1HY1A 5EYTA 2HVGA 3GTDA 5D6BA 1C3UA 1FUPA 1EB4A 1GKMA 4CQ5A 1C3CA 3BHGA 1YISA 4FLCA 1K62A 2X75A 1AUWA 4BABA 1VDKA 5F92A 4ADLA 1FUQA 3KDZA 4V2RA 3RD8A 2O6YA 2QVEA 3R6VA 2O7BA 1YFMA 3KDYA 1YFEA 1T6JA 2O78A 1GKJA 1RE5A 3TV2A 2PTSA 2FUSA 3R6YA 4C6GA 2O7DA 2O7FA 3GZHA 4NLEA 4V2QA 1B8FA 2NYNA 4C5UA 1TJ7A 1J3UA 2RJRA 1U15A 4C5RA 1HY0A 3UNVA 1GK2A 5EYVA 3QBPA 3C8TA 4EEIA 4FFXA 1KQ7A 3RRPA 1Q5NA 1GK3A 1DOFA 1FURA 4EFCA 1I0AA 2E9FA 3NZ4A 4BAAA 2PTRA 4MX2A 1TJWA
chains in the Genus database with same CATH superfamily
2JAWA 2NYFA 2PTQA 1DCNA 4HGVA 4C5SA 1MH9A 3R6QA 3OCEA 3F4RA 3CZOA 4YIKA 4L57A 1W27A 2VD6A 3CRVA 2RJSA 3NO9A 1Q91A 1XWOA 4L6AA 1T6PA 2PFMA 1U16A 2D28C 1Y2MA 4APBA 1K7WA 1TJUA 1FUOA 1XLYA 2O7EA 2J91A 1Z4KA 3U19A 4APAA 3E04A 3OCFA 3U13A 1T9HA 4NSLA 2JAOA 4ADMA 2VL7A 1TJVA 2OHYA 2YIIA 5M0JA 5F91A 1Z4QA 4L6CA 2QGAB 1JSWA 2RCNA 5HW2A 1HY1A 5EYTA 2HVGA 3GTDA 5D6BA 2FELA 1C3UA 1Z4IA 1FUPA 4MUMA 1EB4A 1GKMA 4CQ5A 1Q92A 1C3CA 3BHGA 1YISA 3F4TA 1Z4MA 4FLCA 1K62A 2X75A 4YIHA 1AUWA 1Z4JA 2JAUA 2JARA 4BABA 1VDKA 5F92A 4ADLA 2YV5A 1FUQA 3KDZA 4V2RA 3RD8A 2O6YA 3CRW1 2QVEA 3R6VA 2O7BA 1YFMA 3KDYA 1YFEA 2FENA 1T6JA 1XL8A 2O78A 1GKJA 1RE5A 1IW7D 3TV2A 3BWVA 4MWOA 2PTSA 2FUSA 3R6YA 4WNLA 1Z4PX 4C6GA 4E88A 2O7DA 4IQJM 2O7FA 5M0IA 3GZHA 5H8WA 4NLEA 4V2QA 1B8FA 2NYNA 4C5UA 1XMDA 1TJ7A 1J3UA 1U0LA 4NFLA 1XMCA 1Z4LA 4A15A 2RJRA 3F4SA 1U15A 4C5RA 1HY0A 3UNVA 2D27A 1XL7A 3CI0K 1GK2A 2I7DA 5EYVA 3QBPA 3C8TA 4EEIA 4FFXA 1KQ7A 3RRPA 1Q5NA 1GK3A 1DOFA 1FURA 4EFCA 1I0AA 2E9FA 3NZ4A 4BAAA 2PTRA 2VSFA 4MX2A 1TJWA
chains in the Genus database with same CATH topology
2NYFA 2PTQA 1DCNA 4HGVA 4C5SA 3R6QA 3OCEA 3CZOA 1W27A 2VD6A 2RJSA 3NO9A 1XWOA 1T6PA 2PFMA 1U16A 1Y2MA 4APBA 1K7WA 1TJUA 1FUOA 2O7EA 2J91A 4APAA 3E04A 3OCFA 4NSLA 4ADMA 1TJVA 2OHYA 2YIIA 5F91A 2QGAB 1JSWA 5HW2A 1HY1A 5EYTA 2HVGA 3GTDA 5D6BA 1C3UA 1FUPA 1EB4A 1GKMA 4CQ5A 1C3CA 3BHGA 1YISA 4FLCA 1K62A 2X75A 1AUWA 4BABA 1VDKA 5F92A 4ADLA 1FUQA 3KDZA 4V2RA 3RD8A 2O6YA 2QVEA 3R6VA 2O7BA 1YFMA 3KDYA 1YFEA 1T6JA 2O78A 1GKJA 1RE5A 3TV2A 2PTSA 2FUSA 3R6YA 4C6GA 2O7DA 2O7FA 3GZHA 4NLEA 4V2QA 1B8FA 2NYNA 4C5UA 1TJ7A 1J3UA 2RJRA 1U15A 4C5RA 1HY0A 3UNVA 1GK2A 5EYVA 3QBPA 3C8TA 4EEIA 4FFXA 1KQ7A 3RRPA 1Q5NA 1GK3A 1DOFA 1FURA 4EFCA 1I0AA 2E9FA 3NZ4A 4BAAA 2PTRA 4MX2A 1TJWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NYF A;  2PTQ A;  1DCN A;  4HGV A;  4C5S A;  3R6Q A;  3OCE A;  3CZO A;  1W27 A;  2VD6 A;  2RJS A;  3NO9 A;  1XWO A;  1T6P A;  2PFM A;  1U16 A;  1Y2M A;  4APB A;  1K7W A;  1TJU A;  1FUO A;  2O7E A;  2J91 A;  4APA A;  3E04 A;  3OCF A;  4NSL A;  4ADM A;  1TJV A;  2OHY A;  2YII A;  5F91 A;  2QGA B;  1JSW A;  5HW2 A;  1HY1 A;  5EYT A;  2HVG A;  3GTD A;  5D6B A;  1C3U A;  1FUP A;  1EB4 A;  1GKM A;  4CQ5 A;  1C3C A;  3BHG A;  1YIS A;  4FLC A;  1K62 A;  2X75 A;  1AUW A;  4BAB A;  1VDK A;  5F92 A;  4ADL A;  1FUQ A;  3KDZ A;  4V2R A;  3RD8 A;  2O6Y A;  2QVE A;  3R6V A;  2O7B A;  1YFM A;  3KDY A;  1YFE A;  1T6J A;  2O78 A;  1GKJ A;  1RE5 A;  3TV2 A;  2PTS A;  2FUS A;  3R6Y A;  4C6G A;  2O7D A;  2O7F A;  3GZH A;  4NLE A;  4V2Q A;  1B8F A;  2NYN A;  4C5U A;  1TJ7 A;  1J3U A;  2RJR A;  1U15 A;  4C5R A;  1HY0 A;  3UNV A;  1GK2 A;  5EYV A;  3QBP A;  3C8T A;  4EEI A;  4FFX A;  1KQ7 A;  3RRP A;  1Q5N A;  1GK3 A;  1DOF A;  1FUR A;  4EFC A;  1I0A A;  2E9F A;  3NZ4 A;  4BAA A;  2PTR A;  4MX2 A;  1TJW A; 
#chains in the Genus database with same CATH topology
 2JAW A;  2NYF A;  2PTQ A;  1DCN A;  4HGV A;  4C5S A;  1MH9 A;  3R6Q A;  3OCE A;  3F4R A;  3CZO A;  4YIK A;  4L57 A;  1W27 A;  2VD6 A;  3CRV A;  2RJS A;  3NO9 A;  1Q91 A;  1XWO A;  4L6A A;  1T6P A;  2PFM A;  1U16 A;  2D28 C;  1Y2M A;  4APB A;  1K7W A;  1TJU A;  1FUO A;  1XLY A;  2O7E A;  2J91 A;  1Z4K A;  3U19 A;  4APA A;  3E04 A;  3OCF A;  3U13 A;  1T9H A;  4NSL A;  2JAO A;  4ADM A;  2VL7 A;  1TJV A;  2OHY A;  2YII A;  5M0J A;  5F91 A;  1Z4Q A;  4L6C A;  2QGA B;  1JSW A;  2RCN A;  5HW2 A;  1HY1 A;  5EYT A;  2HVG A;  3GTD A;  5D6B A;  2FEL A;  1C3U A;  1Z4I A;  1FUP A;  4MUM A;  1EB4 A;  1GKM A;  4CQ5 A;  1Q92 A;  1C3C A;  3BHG A;  1YIS A;  3F4T A;  1Z4M A;  4FLC A;  1K62 A;  2X75 A;  4YIH A;  1AUW A;  1Z4J A;  2JAU A;  2JAR A;  4BAB A;  1VDK A;  5F92 A;  4ADL A;  2YV5 A;  1FUQ A;  3KDZ A;  4V2R A;  3RD8 A;  2O6Y A;  3CRW 1;  2QVE A;  3R6V A;  2O7B A;  1YFM A;  3KDY A;  1YFE A;  2FEN A;  1T6J A;  1XL8 A;  2O78 A;  1GKJ A;  1RE5 A;  1IW7 D;  3TV2 A;  3BWV A;  4MWO A;  2PTS A;  2FUS A;  3R6Y A;  4WNL A;  1Z4P X;  4C6G A;  4E88 A;  2O7D A;  4IQJ M;  2O7F A;  5M0I A;  3GZH A;  5H8W A;  4NLE A;  4V2Q A;  1B8F A;  2NYN A;  4C5U A;  1XMD A;  1TJ7 A;  1J3U A;  1U0L A;  4NFL A;  1XMC A;  1Z4L A;  4A15 A;  2RJR A;  3F4S A;  1U15 A;  4C5R A;  1HY0 A;  3UNV A;  2D27 A;  1XL7 A;  3CI0 K;  1GK2 A;  2I7D A;  5EYV A;  3QBP A;  3C8T A;  4EEI A;  4FFX A;  1KQ7 A;  3RRP A;  1Q5N A;  1GK3 A;  1DOF A;  1FUR A;  4EFC A;  1I0A A;  2E9F A;  3NZ4 A;  4BAA A;  2PTR A;  2VSF A;  4MX2 A;  1TJW A; 
#chains in the Genus database with same CATH homology
 2NYF A;  2PTQ A;  1DCN A;  4HGV A;  4C5S A;  3R6Q A;  3OCE A;  3CZO A;  1W27 A;  2VD6 A;  2RJS A;  3NO9 A;  1XWO A;  1T6P A;  2PFM A;  1U16 A;  1Y2M A;  4APB A;  1K7W A;  1TJU A;  1FUO A;  2O7E A;  2J91 A;  4APA A;  3E04 A;  3OCF A;  4NSL A;  4ADM A;  1TJV A;  2OHY A;  2YII A;  5F91 A;  2QGA B;  1JSW A;  5HW2 A;  1HY1 A;  5EYT A;  2HVG A;  3GTD A;  5D6B A;  1C3U A;  1FUP A;  1EB4 A;  1GKM A;  4CQ5 A;  1C3C A;  3BHG A;  1YIS A;  4FLC A;  1K62 A;  2X75 A;  1AUW A;  4BAB A;  1VDK A;  5F92 A;  4ADL A;  1FUQ A;  3KDZ A;  4V2R A;  3RD8 A;  2O6Y A;  2QVE A;  3R6V A;  2O7B A;  1YFM A;  3KDY A;  1YFE A;  1T6J A;  2O78 A;  1GKJ A;  1RE5 A;  3TV2 A;  2PTS A;  2FUS A;  3R6Y A;  4C6G A;  2O7D A;  2O7F A;  3GZH A;  4NLE A;  4V2Q A;  1B8F A;  2NYN A;  4C5U A;  1TJ7 A;  1J3U A;  2RJR A;  1U15 A;  4C5R A;  1HY0 A;  3UNV A;  1GK2 A;  5EYV A;  3QBP A;  3C8T A;  4EEI A;  4FFX A;  1KQ7 A;  3RRP A;  1Q5N A;  1GK3 A;  1DOF A;  1FUR A;  4EFC A;  1I0A A;  2E9F A;  3NZ4 A;  4BAA A;  2PTR A;  4MX2 A;  1TJW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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