5F91A

Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator (n-(5-(azepan-1-ylsulfonyl)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide)
Total Genus 176
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
176
sequence length
459
structure length
447
Chain Sequence
NYRIEHEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Fumarate hydratase class II
publication title Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
pubmed doi rcsb
source organism Mycobacterium tuberculosis (strain cdc 1551 / oshkosh)
molecule tags Lyase/lyase inhibitor
total genus 176
structure length 447
sequence length 459
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2015-12-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 5f91A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 5f91A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 5f91A02
1VDKA 1TJVA 2O7DA 1FUOA 4APAA 1W27A 1YFEA 1RE5A 1GK2A 1DOFA 4CQ5A 2J91A 5EYTA 1C3UA 1FURA 2NYFA 2NYNA 3CZOA 2FUSA 4BAAA 1B8FA 5F92A 2O7FA 5F91A 3KDZA 3NO9A 2YIIA 4NSLA 4ADLA 3TV2A 1Y2MA 3R6YA 1KQ7A 3OCFA 1TJ7A 2O7BA 1C3CA 1T6JA 4BABA 1AUWA 1FUPA 2O78A 2E9FA 4APBA 3BHGA 4EFCA 2PFMA 3E04A 3GTDA 2O7EA 1HY0A 1FUQA 3RRPA 3C8TA 2RJRA 1EB4A 4FFXA 3KDYA 4V2QA 2PTRA 2PTQA 5HW2A 4C6GA 1HY1A 1DCNA 2RJSA 1TJUA 1GKJA 3R6VA 4C5RA 4HGVA 1TJWA 4FLCA 1U15A 2HVGA 1I0AA 3OCEA 4V2RA 3R6QA 1GKMA 1K62A 4NLEA 5EYVA 2O6YA 1GK3A 4C5SA 5D6BA 1K7WA 3UNVA 2X75A 3GZHA 1T6PA 1YISA 4EEIA 2PTSA 1XWOA 1J3UA 3QBPA 1YFMA 4ADMA 2OHYA 2VD6A 3RD8A 4C5UA 2QVEA 2QGAB 1Q5NA 4MX2A 3NZ4A 1JSWA 1U16A
chains in the Genus database with same CATH superfamily
3U19A 1VDKA 1TJVA 2O7DA 2D27A 1FUOA 4APAA 1Q92A 1W27A 1YFEA 1Z4QA 2VL7A 1RE5A 1GK2A 4L6CA 1DOFA 4CQ5A 2J91A 5EYTA 1C3UA 2FELA 1FURA 3CI0K 1IW7D 2NYFA 2NYNA 3CZOA 2FUSA 4BAAA 1B8FA 3CRW1 5F92A 2O7FA 5F91A 3KDZA 3NO9A 2YIIA 4NSLA 4ADLA 3TV2A 1XMDA 1Y2MA 3R6YA 1KQ7A 4A15A 3OCFA 1TJ7A 1XL8A 2O7BA 4YIKA 1C3CA 1T6JA 4E88A 4MWOA 2I7DA 3F4TA 4IQJM 4BABA 1Z4MA 1AUWA 1FUPA 2O78A 2E9FA 4APBA 3BHGA 4MUMA 4EFCA 2PFMA 2JAWA 1U0LA 3E04A 3GTDA 4NFLA 2O7EA 1HY0A 2JAUA 2FENA 1FUQA 3RRPA 3BWVA 3C8TA 2RJRA 1EB4A 1XLYA 4FFXA 3KDYA 1XMCA 4V2QA 2PTRA 2PTQA 5HW2A 4C6GA 1HY1A 1Q91A 4YIHA 1DCNA 2RJSA 3F4RA 1Z4IA 1TJUA 1GKJA 3R6VA 2RCNA 4HGVA 4C5RA 1Z4JA 1TJWA 4FLCA 1U15A 2HVGA 1I0AA 3OCEA 4V2RA 4WNLA 2JAOA 3R6QA 1GKMA 1Z4LA 1K62A 3U13A 4NLEA 5EYVA 2O6YA 1Z4PX 1GK3A 4L6AA 2VSFA 2D28C 1XL7A 5D6BA 4C5SA 1K7WA 3UNVA 2X75A 3GZHA 1T6PA 1YISA 1MH9A 3CRVA 5H8WA 4EEIA 2PTSA 1XWOA 5M0JA 1J3UA 3F4SA 3QBPA 1T9HA 5M0IA 1YFMA 4L57A 2YV5A 4ADMA 3RD8A 2OHYA 2VD6A 4C5UA 2QVEA 2QGAB 1Q5NA 4MX2A 2JARA 3NZ4A 1Z4KA 1JSWA 1U16A
chains in the Genus database with same CATH topology
1VDKA 1TJVA 2O7DA 1FUOA 4APAA 1W27A 1YFEA 1RE5A 1GK2A 1DOFA 4CQ5A 2J91A 5EYTA 1C3UA 1FURA 2NYFA 2NYNA 3CZOA 2FUSA 4BAAA 1B8FA 5F92A 2O7FA 5F91A 3KDZA 3NO9A 2YIIA 4NSLA 4ADLA 3TV2A 1Y2MA 3R6YA 1KQ7A 3OCFA 1TJ7A 2O7BA 1C3CA 1T6JA 4BABA 1AUWA 1FUPA 2O78A 2E9FA 4APBA 3BHGA 4EFCA 2PFMA 3E04A 3GTDA 2O7EA 1HY0A 1FUQA 3RRPA 3C8TA 2RJRA 1EB4A 4FFXA 3KDYA 4V2QA 2PTRA 2PTQA 5HW2A 4C6GA 1HY1A 1DCNA 2RJSA 1TJUA 1GKJA 3R6VA 4C5RA 4HGVA 1TJWA 4FLCA 1U15A 2HVGA 1I0AA 3OCEA 4V2RA 3R6QA 1GKMA 1K62A 4NLEA 5EYVA 2O6YA 1GK3A 4C5SA 5D6BA 1K7WA 3UNVA 2X75A 3GZHA 1T6PA 1YISA 4EEIA 2PTSA 1XWOA 1J3UA 3QBPA 1YFMA 4ADMA 2OHYA 2VD6A 3RD8A 4C5UA 2QVEA 2QGAB 1Q5NA 4MX2A 3NZ4A 1JSWA 1U16A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1VDK A;  1TJV A;  2O7D A;  1FUO A;  4APA A;  1W27 A;  1YFE A;  1RE5 A;  1GK2 A;  1DOF A;  4CQ5 A;  2J91 A;  5EYT A;  1C3U A;  1FUR A;  2NYF A;  2NYN A;  3CZO A;  2FUS A;  4BAA A;  1B8F A;  5F92 A;  2O7F A;  5F91 A;  3KDZ A;  3NO9 A;  2YII A;  4NSL A;  4ADL A;  3TV2 A;  1Y2M A;  3R6Y A;  1KQ7 A;  3OCF A;  1TJ7 A;  2O7B A;  1C3C A;  1T6J A;  4BAB A;  1AUW A;  1FUP A;  2O78 A;  2E9F A;  4APB A;  3BHG A;  4EFC A;  2PFM A;  3E04 A;  3GTD A;  2O7E A;  1HY0 A;  1FUQ A;  3RRP A;  3C8T A;  2RJR A;  1EB4 A;  4FFX A;  3KDY A;  4V2Q A;  2PTR A;  2PTQ A;  5HW2 A;  4C6G A;  1HY1 A;  1DCN A;  2RJS A;  1TJU A;  1GKJ A;  3R6V A;  4C5R A;  4HGV A;  1TJW A;  4FLC A;  1U15 A;  2HVG A;  1I0A A;  3OCE A;  4V2R A;  3R6Q A;  1GKM A;  1K62 A;  4NLE A;  5EYV A;  2O6Y A;  1GK3 A;  4C5S A;  5D6B A;  1K7W A;  3UNV A;  2X75 A;  3GZH A;  1T6P A;  1YIS A;  4EEI A;  2PTS A;  1XWO A;  1J3U A;  3QBP A;  1YFM A;  4ADM A;  2OHY A;  2VD6 A;  3RD8 A;  4C5U A;  2QVE A;  2QGA B;  1Q5N A;  4MX2 A;  3NZ4 A;  1JSW A;  1U16 A; 
#chains in the Genus database with same CATH topology
 3U19 A;  1VDK A;  1TJV A;  2O7D A;  2D27 A;  1FUO A;  4APA A;  1Q92 A;  1W27 A;  1YFE A;  1Z4Q A;  2VL7 A;  1RE5 A;  1GK2 A;  4L6C A;  1DOF A;  4CQ5 A;  2J91 A;  5EYT A;  1C3U A;  2FEL A;  1FUR A;  3CI0 K;  1IW7 D;  2NYF A;  2NYN A;  3CZO A;  2FUS A;  4BAA A;  1B8F A;  3CRW 1;  5F92 A;  2O7F A;  5F91 A;  3KDZ A;  3NO9 A;  2YII A;  4NSL A;  4ADL A;  3TV2 A;  1XMD A;  1Y2M A;  3R6Y A;  1KQ7 A;  4A15 A;  3OCF A;  1TJ7 A;  1XL8 A;  2O7B A;  4YIK A;  1C3C A;  1T6J A;  4E88 A;  4MWO A;  2I7D A;  3F4T A;  4IQJ M;  4BAB A;  1Z4M A;  1AUW A;  1FUP A;  2O78 A;  2E9F A;  4APB A;  3BHG A;  4MUM A;  4EFC A;  2PFM A;  2JAW A;  1U0L A;  3E04 A;  3GTD A;  4NFL A;  2O7E A;  1HY0 A;  2JAU A;  2FEN A;  1FUQ A;  3RRP A;  3BWV A;  3C8T A;  2RJR A;  1EB4 A;  1XLY A;  4FFX A;  3KDY A;  1XMC A;  4V2Q A;  2PTR A;  2PTQ A;  5HW2 A;  4C6G A;  1HY1 A;  1Q91 A;  4YIH A;  1DCN A;  2RJS A;  3F4R A;  1Z4I A;  1TJU A;  1GKJ A;  3R6V A;  2RCN A;  4HGV A;  4C5R A;  1Z4J A;  1TJW A;  4FLC A;  1U15 A;  2HVG A;  1I0A A;  3OCE A;  4V2R A;  4WNL A;  2JAO A;  3R6Q A;  1GKM A;  1Z4L A;  1K62 A;  3U13 A;  4NLE A;  5EYV A;  2O6Y A;  1Z4P X;  1GK3 A;  4L6A A;  2VSF A;  2D28 C;  1XL7 A;  5D6B A;  4C5S A;  1K7W A;  3UNV A;  2X75 A;  3GZH A;  1T6P A;  1YIS A;  1MH9 A;  3CRV A;  5H8W A;  4EEI A;  2PTS A;  1XWO A;  5M0J A;  1J3U A;  3F4S A;  3QBP A;  1T9H A;  5M0I A;  1YFM A;  4L57 A;  2YV5 A;  4ADM A;  3RD8 A;  2OHY A;  2VD6 A;  4C5U A;  2QVE A;  2QGA B;  1Q5N A;  4MX2 A;  2JAR A;  3NZ4 A;  1Z4K A;  1JSW A;  1U16 A; 
#chains in the Genus database with same CATH homology
 1VDK A;  1TJV A;  2O7D A;  1FUO A;  4APA A;  1W27 A;  1YFE A;  1RE5 A;  1GK2 A;  1DOF A;  4CQ5 A;  2J91 A;  5EYT A;  1C3U A;  1FUR A;  2NYF A;  2NYN A;  3CZO A;  2FUS A;  4BAA A;  1B8F A;  5F92 A;  2O7F A;  5F91 A;  3KDZ A;  3NO9 A;  2YII A;  4NSL A;  4ADL A;  3TV2 A;  1Y2M A;  3R6Y A;  1KQ7 A;  3OCF A;  1TJ7 A;  2O7B A;  1C3C A;  1T6J A;  4BAB A;  1AUW A;  1FUP A;  2O78 A;  2E9F A;  4APB A;  3BHG A;  4EFC A;  2PFM A;  3E04 A;  3GTD A;  2O7E A;  1HY0 A;  1FUQ A;  3RRP A;  3C8T A;  2RJR A;  1EB4 A;  4FFX A;  3KDY A;  4V2Q A;  2PTR A;  2PTQ A;  5HW2 A;  4C6G A;  1HY1 A;  1DCN A;  2RJS A;  1TJU A;  1GKJ A;  3R6V A;  4C5R A;  4HGV A;  1TJW A;  4FLC A;  1U15 A;  2HVG A;  1I0A A;  3OCE A;  4V2R A;  3R6Q A;  1GKM A;  1K62 A;  4NLE A;  5EYV A;  2O6Y A;  1GK3 A;  4C5S A;  5D6B A;  1K7W A;  3UNV A;  2X75 A;  3GZH A;  1T6P A;  1YIS A;  4EEI A;  2PTS A;  1XWO A;  1J3U A;  3QBP A;  1YFM A;  4ADM A;  2OHY A;  2VD6 A;  3RD8 A;  4C5U A;  2QVE A;  2QGA B;  1Q5N A;  4MX2 A;  3NZ4 A;  1JSW A;  1U16 A; 
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