The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
176
|
sequence length |
459
|
structure length |
447
|
Chain Sequence |
NYRIEHEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAE
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
pubmed doi rcsb |
| molecule keywords |
Fumarate hydratase class II
|
| molecule tags |
Lyase/lyase inhibitor
|
| source organism |
Mycobacterium tuberculosis (strain cdc 1551 / oshkosh)
|
| total genus |
176
|
| structure length |
447
|
| sequence length |
459
|
| chains with identical sequence |
B, C, D
|
| ec nomenclature |
ec
4.2.1.2: Fumarate hydratase. |
| pdb deposition date | 2015-12-09 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00206 | Lyase_1 | Lyase |
| A | PF10415 | FumaraseC_C | Fumarase C C-terminus |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Orthogonal Bundle | Ribonucleotide Reductase Protein R1; domain 1 | Fumarase/aspartase (C-terminal domain) | ||
| Mainly Alpha | Orthogonal Bundle | Fumarase C; Chain B, domain 1 | Fumarase/aspartase (N-terminal domain) | ||
| Mainly Alpha | Up-down Bundle | Fumarase C; Chain A, domain 2 | Fumarase/aspartase (Central domain) |
#chains in the Genus database with same CATH superfamily 1HY0 A; 1AUW A; 5EYV A; 4HGV A; 2NYF A; 4APA A; 2NYN A; 3CZO A; 3OCF A; 5EYT A; 3R6V A; 1K62 A; 3OCE A; 2E9F A; 2VD6 A; 4V2R A; 5F92 A; 3NO9 A; 1C3U A; 2HVG A; 4C5S A; 1U16 A; 1T6J A; 1EB4 A; 3R6Q A; 1K7W A; 2RJR A; 1YFE A; 3NZ4 A; 1DOF A; 2O6Y A; 1TJW A; 4APB A; 2O78 A; 1J3U A; 4BAA A; 1GK2 A; 2QVE A; 1JSW A; 2O7F A; 3UNV A; 4EEI A; 5HW2 A; 1W27 A; 3QBP A; 1B8F A; 2OHY A; 2PTQ A; 4NSL A; 1DCN A; 2O7E A; 1YFM A; 3C8T A; 1YIS A; 1TJU A; 2RJS A; 4FLC A; 5F91 A; 2QGA B; 3GZH A; 1FUP A; 2PFM A; 1XWO A; 4C5U A; 4MX2 A; 1HY1 A; 1FUR A; 1Q5N A; 3GTD A; 3TV2 A; 5D6B A; 4EFC A; 2O7D A; 1GK3 A; 1GKJ A; 1C3C A; 1VDK A; 3BHG A; 2X75 A; 2PTS A; 4BAB A; 4V2Q A; 4ADM A; 3R6Y A; 2FUS A; 3RD8 A; 1U15 A; 3RRP A; 2O7B A; 4C5R A; 4CQ5 A; 1GKM A; 4FFX A; 2YII A; 1I0A A; 1TJ7 A; 4C6G A; 1T6P A; 1Y2M A; 4ADL A; 2J91 A; 3KDZ A; 2PTR A; 3KDY A; 4NLE A; 1FUQ A; 1FUO A; 1KQ7 A; 3E04 A; 1TJV A; 1RE5 A; #chains in the Genus database with same CATH topology 2JAU A; 1HY0 A; 1U0L A; 1AUW A; 1XLY A; 5EYV A; 4HGV A; 2NYF A; 4NFL A; 5H8W A; 2D28 C; 4APA A; 2NYN A; 3CZO A; 3OCF A; 5EYT A; 3R6V A; 5M0I A; 1K62 A; 3OCE A; 3F4T A; 2E9F A; 2VD6 A; 4V2R A; 3U19 A; 5F92 A; 1Q91 A; 3NO9 A; 4L6A A; 1C3U A; 2HVG A; 4C5S A; 1U16 A; 1T6J A; 1EB4 A; 3R6Q A; 1K7W A; 2RJR A; 1YFE A; 3NZ4 A; 4YIK A; 1DOF A; 2O6Y A; 1TJW A; 4APB A; 2O78 A; 1J3U A; 1Q92 A; 4BAA A; 4A15 A; 1GK2 A; 2QVE A; 1T9H A; 1XMD A; 1JSW A; 2O7F A; 3UNV A; 4EEI A; 5M0J A; 5HW2 A; 1IW7 D; 3F4R A; 4L6C A; 1Z4L A; 1W27 A; 3QBP A; 1B8F A; 2OHY A; 2PTQ A; 4NSL A; 1DCN A; 2O7E A; 3U13 A; 1RE5 A; 4MWO A; 1Z4P X; 2I7D A; 1YFM A; 3C8T A; 1TJU A; 1YIS A; 2RJS A; 4FLC A; 5F91 A; 2JAO A; 2RCN A; 2QGA B; 3GZH A; 1FUP A; 2PFM A; 1XWO A; 4C5U A; 4MX2 A; 4MUM A; 3F4S A; 4L57 A; 1HY1 A; 1FUR A; 1Q5N A; 3GTD A; 3TV2 A; 5D6B A; 1XMC A; 2VL7 A; 1Z4J A; 1Z4Q A; 3CI0 K; 4EFC A; 2O7D A; 1GK3 A; 1GKJ A; 2JAR A; 1C3C A; 1VDK A; 3BHG A; 3CRV A; 2X75 A; 1Z4M A; 2VSF A; 2PTS A; 1XL8 A; 4BAB A; 4V2Q A; 4ADM A; 3R6Y A; 2FUS A; 1XL7 A; 3RD8 A; 1U15 A; 3RRP A; 2O7B A; 4WNL A; 3BWV A; 4C5R A; 4CQ5 A; 1GKM A; 2FEL A; 4FFX A; 2YII A; 1I0A A; 1TJ7 A; 4C6G A; 1T6P A; 1Y2M A; 1Z4I A; 2JAW A; 4ADL A; 2YV5 A; 2FEN A; 2J91 A; 3KDZ A; 2PTR A; 3KDY A; 2D27 A; 4NLE A; 1FUQ A; 4IQJ M; 1FUO A; 1KQ7 A; 3CRW 1; 3E04 A; 4YIH A; 4E88 A; 1TJV A; 1MH9 A; 1Z4K A; #chains in the Genus database with same CATH homology 1HY0 A; 1AUW A; 5EYV A; 4HGV A; 2NYF A; 4APA A; 2NYN A; 3CZO A; 3OCF A; 5EYT A; 3R6V A; 1K62 A; 3OCE A; 2E9F A; 2VD6 A; 4V2R A; 5F92 A; 3NO9 A; 1C3U A; 2HVG A; 4C5S A; 1U16 A; 1T6J A; 1EB4 A; 3R6Q A; 1K7W A; 2RJR A; 1YFE A; 3NZ4 A; 1DOF A; 2O6Y A; 1TJW A; 4APB A; 2O78 A; 1J3U A; 4BAA A; 1GK2 A; 2QVE A; 1JSW A; 2O7F A; 3UNV A; 4EEI A; 5HW2 A; 1W27 A; 3QBP A; 1B8F A; 2OHY A; 2PTQ A; 4NSL A; 1DCN A; 2O7E A; 1YFM A; 3C8T A; 1YIS A; 1TJU A; 2RJS A; 4FLC A; 5F91 A; 2QGA B; 3GZH A; 1FUP A; 2PFM A; 1XWO A; 4C5U A; 4MX2 A; 1HY1 A; 1FUR A; 1Q5N A; 3GTD A; 3TV2 A; 5D6B A; 4EFC A; 2O7D A; 1GK3 A; 1GKJ A; 1C3C A; 1VDK A; 3BHG A; 2X75 A; 2PTS A; 4BAB A; 4V2Q A; 4ADM A; 3R6Y A; 2FUS A; 3RD8 A; 1U15 A; 3RRP A; 2O7B A; 4C5R A; 4CQ5 A; 1GKM A; 4FFX A; 2YII A; 1I0A A; 1TJ7 A; 4C6G A; 1T6P A; 1Y2M A; 4ADL A; 2J91 A; 3KDZ A; 2PTR A; 3KDY A; 4NLE A; 1FUQ A; 1FUO A; 1KQ7 A; 3E04 A; 1TJV A; 1RE5 A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
