1DOFA

The crystal structure of adenylosuccinate lyase from pyrobaculum aerophilum: insights into thermal stability and human pathology
Total Genus 153
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
153
sequence length
402
structure length
385
Chain Sequence
HVSPFDWRYGSEEIRRLFTNEAIINAYLEVERALVCALEELGVAERGCCEKVNKASVSADEVHDILSLVLLLEQKSGCRYVHYGATSNDIIDTAWALLIRRALAAVKEKARAVGDQLASMARKYKTLEMVGRTHGQWAEPITLGFKFANYYYELYIACRQLALAEEFIRAKIGGAVGTMASWGELGLEVRRRVAERLGLPHHVITTQVAPRESFAVLASALALMAAVFERLAVEIRELSRPEIGEVVEGGANPTASERIVSLARYVRALTHVAFENVALWHERDLTNSANERVWIPEALLALDEILTSALRVLKNVYIDEERITENLQKALPYILTEFHMNRMIKEGASRAEAYKKAKEVKALTFEYQKWPVERLIEDALSLKLC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds.
pubmed doi rcsb
source organism Pyrobaculum aerophilum
molecule tags Lyase
molecule keywords ADENYLOSUCCINATE LYASE
total genus 153
structure length 385
sequence length 402
chains with identical sequence B, C, D
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 1999-12-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 1dofA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1dofA02
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1dofA01
2O7BA 1GK3A 2YIIA 4NSLA 1GK2A 3KDZA 3GTDA 1XWOA 5D6BA 2VD6A 2X75A 4HGVA 3KDYA 2OHYA 1TJWA 4CQ5A 3RD8A 3C8TA 3OCFA 4V2RA 5F92A 2NYNA 4V2QA 1B8FA 1FUOA 1AUWA 2QVEA 3NO9A 2RJSA 4NLEA 2HVGA 4FFXA 1Q5NA 3BHGA 2PTSA 3UNVA 4ADLA 4FLCA 1RE5A 3GZHA 4EEIA 5EYTA 1YFEA 2O78A 1TJVA 1VDKA 1FUQA 3CZOA 1KQ7A 2RJRA 1I0AA 1T6PA 1GKJA 1W27A 1EB4A 2FUSA 2E9FA 1Y2MA 1U16A 4APAA 1JSWA 1J3UA 2O7FA 5F91A 3TV2A 1U15A 3R6QA 1FURA 2PTQA 1TJUA 4C5RA 4ADMA 3RRPA 3E04A 5HW2A 4APBA 1YISA 1T6JA 1FUPA 4EFCA 1GKMA 1TJ7A 3OCEA 2O7EA 3NZ4A 4MX2A 1DCNA 2O6YA 4C5UA 2J91A 3R6YA 1YFMA 5EYVA 4BABA 1DOFA 2PFMA 1HY1A 4C5SA 2QGAB 1C3UA 1K62A 2NYFA 1C3CA 3QBPA 4C6GA 4BAAA 2PTRA 1K7WA 2O7DA 1HY0A 3R6VA
chains in the Genus database with same CATH superfamily
2O7BA 1XL7A 5M0JA 1GK3A 2YIIA 4NSLA 1GK2A 2FENA 3KDZA 3GTDA 1XWOA 5D6BA 4E88A 2D27A 2VD6A 2X75A 1IW7D 4HGVA 5H8WA 2JAWA 3KDYA 2OHYA 1TJWA 4CQ5A 1Z4KA 3RD8A 3C8TA 4L6CA 3OCFA 4V2RA 5F92A 2NYNA 4MUMA 4V2QA 1T9HA 3U13A 1Q91A 1B8FA 1FUOA 4YIHA 1AUWA 1Q92A 2QVEA 3NO9A 2RJSA 4NLEA 2HVGA 2VSFA 4FFXA 1Q5NA 2JARA 2I7DA 3BHGA 2PTSA 4WNLA 3UNVA 4ADLA 3CRVA 4NFLA 4FLCA 1RE5A 1Z4IA 3GZHA 4EEIA 5EYTA 1YFEA 1Z4MA 2O78A 1TJVA 3U19A 4L6AA 3F4SA 1VDKA 2JAOA 1XL8A 1FUQA 3CZOA 1KQ7A 2RJRA 1I0AA 1T6PA 4IQJM 2JAUA 1GKJA 2D28C 1W27A 1Z4PX 1EB4A 2FUSA 2E9FA 1Y2MA 1U16A 4APAA 2FELA 4YIKA 1JSWA 3BWVA 1XMDA 1J3UA 2O7FA 5F91A 3TV2A 3F4RA 1U15A 3CI0K 3R6QA 1Z4QA 1FURA 2PTQA 1TJUA 4C5RA 4A15A 4ADMA 2YV5A 1MH9A 3RRPA 3E04A 5HW2A 4APBA 3F4TA 4MWOA 1YISA 1T6JA 2RCNA 1FUPA 4EFCA 5M0IA 1GKMA 1TJ7A 3OCEA 2O7EA 3NZ4A 4MX2A 1DCNA 2O6YA 4C5UA 1Z4JA 1Z4LA 3CRW1 2J91A 3R6YA 1YFMA 5EYVA 4BABA 1DOFA 2PFMA 1HY1A 4C5SA 2QGAB 1C3UA 1K62A 2NYFA 1C3CA 1XLYA 1U0LA 3QBPA 1XMCA 4C6GA 4BAAA 4L57A 2VL7A 2PTRA 1K7WA 2O7DA 1HY0A 3R6VA
chains in the Genus database with same CATH topology
2O7BA 1GK3A 2YIIA 4NSLA 1GK2A 3KDZA 3GTDA 1XWOA 5D6BA 2VD6A 2X75A 4HGVA 3KDYA 2OHYA 1TJWA 4CQ5A 3RD8A 3C8TA 3OCFA 4V2RA 5F92A 2NYNA 4V2QA 1B8FA 1FUOA 1AUWA 2QVEA 3NO9A 2RJSA 4NLEA 2HVGA 4FFXA 1Q5NA 3BHGA 2PTSA 3UNVA 4ADLA 4FLCA 1RE5A 3GZHA 4EEIA 5EYTA 1YFEA 2O78A 1TJVA 1VDKA 1FUQA 3CZOA 1KQ7A 2RJRA 1I0AA 1T6PA 1GKJA 1W27A 1EB4A 2FUSA 2E9FA 1Y2MA 1U16A 4APAA 1JSWA 1J3UA 2O7FA 5F91A 3TV2A 1U15A 3R6QA 1FURA 2PTQA 1TJUA 4C5RA 4ADMA 3RRPA 3E04A 5HW2A 4APBA 1YISA 1T6JA 1FUPA 4EFCA 1GKMA 1TJ7A 3OCEA 2O7EA 3NZ4A 4MX2A 1DCNA 2O6YA 4C5UA 2J91A 3R6YA 1YFMA 5EYVA 4BABA 1DOFA 2PFMA 1HY1A 4C5SA 2QGAB 1C3UA 1K62A 2NYFA 1C3CA 3QBPA 4C6GA 4BAAA 2PTRA 1K7WA 2O7DA 1HY0A 3R6VA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2O7B A;  1GK3 A;  2YII A;  4NSL A;  1GK2 A;  3KDZ A;  3GTD A;  1XWO A;  5D6B A;  2VD6 A;  2X75 A;  4HGV A;  3KDY A;  2OHY A;  1TJW A;  4CQ5 A;  3RD8 A;  3C8T A;  3OCF A;  4V2R A;  5F92 A;  2NYN A;  4V2Q A;  1B8F A;  1FUO A;  1AUW A;  2QVE A;  3NO9 A;  2RJS A;  4NLE A;  2HVG A;  4FFX A;  1Q5N A;  3BHG A;  2PTS A;  3UNV A;  4ADL A;  4FLC A;  1RE5 A;  3GZH A;  4EEI A;  5EYT A;  1YFE A;  2O78 A;  1TJV A;  1VDK A;  1FUQ A;  3CZO A;  1KQ7 A;  2RJR A;  1I0A A;  1T6P A;  1GKJ A;  1W27 A;  1EB4 A;  2FUS A;  2E9F A;  1Y2M A;  1U16 A;  4APA A;  1JSW A;  1J3U A;  2O7F A;  5F91 A;  3TV2 A;  1U15 A;  3R6Q A;  1FUR A;  2PTQ A;  1TJU A;  4C5R A;  4ADM A;  3RRP A;  3E04 A;  5HW2 A;  4APB A;  1YIS A;  1T6J A;  1FUP A;  4EFC A;  1GKM A;  1TJ7 A;  3OCE A;  2O7E A;  3NZ4 A;  4MX2 A;  1DCN A;  2O6Y A;  4C5U A;  2J91 A;  3R6Y A;  1YFM A;  5EYV A;  4BAB A;  1DOF A;  2PFM A;  1HY1 A;  4C5S A;  2QGA B;  1C3U A;  1K62 A;  2NYF A;  1C3C A;  3QBP A;  4C6G A;  4BAA A;  2PTR A;  1K7W A;  2O7D A;  1HY0 A;  3R6V A; 
#chains in the Genus database with same CATH topology
 2O7B A;  1XL7 A;  5M0J A;  1GK3 A;  2YII A;  4NSL A;  1GK2 A;  2FEN A;  3KDZ A;  3GTD A;  1XWO A;  5D6B A;  4E88 A;  2D27 A;  2VD6 A;  2X75 A;  1IW7 D;  4HGV A;  5H8W A;  2JAW A;  3KDY A;  2OHY A;  1TJW A;  4CQ5 A;  1Z4K A;  3RD8 A;  3C8T A;  4L6C A;  3OCF A;  4V2R A;  5F92 A;  2NYN A;  4MUM A;  4V2Q A;  1T9H A;  3U13 A;  1Q91 A;  1B8F A;  1FUO A;  4YIH A;  1AUW A;  1Q92 A;  2QVE A;  3NO9 A;  2RJS A;  4NLE A;  2HVG A;  2VSF A;  4FFX A;  1Q5N A;  2JAR A;  2I7D A;  3BHG A;  2PTS A;  4WNL A;  3UNV A;  4ADL A;  3CRV A;  4NFL A;  4FLC A;  1RE5 A;  1Z4I A;  3GZH A;  4EEI A;  5EYT A;  1YFE A;  1Z4M A;  2O78 A;  1TJV A;  3U19 A;  4L6A A;  3F4S A;  1VDK A;  2JAO A;  1XL8 A;  1FUQ A;  3CZO A;  1KQ7 A;  2RJR A;  1I0A A;  1T6P A;  4IQJ M;  2JAU A;  1GKJ A;  2D28 C;  1W27 A;  1Z4P X;  1EB4 A;  2FUS A;  2E9F A;  1Y2M A;  1U16 A;  4APA A;  2FEL A;  4YIK A;  1JSW A;  3BWV A;  1XMD A;  1J3U A;  2O7F A;  5F91 A;  3TV2 A;  3F4R A;  1U15 A;  3CI0 K;  3R6Q A;  1Z4Q A;  1FUR A;  2PTQ A;  1TJU A;  4C5R A;  4A15 A;  4ADM A;  2YV5 A;  1MH9 A;  3RRP A;  3E04 A;  5HW2 A;  4APB A;  3F4T A;  4MWO A;  1YIS A;  1T6J A;  2RCN A;  1FUP A;  4EFC A;  5M0I A;  1GKM A;  1TJ7 A;  3OCE A;  2O7E A;  3NZ4 A;  4MX2 A;  1DCN A;  2O6Y A;  4C5U A;  1Z4J A;  1Z4L A;  3CRW 1;  2J91 A;  3R6Y A;  1YFM A;  5EYV A;  4BAB A;  1DOF A;  2PFM A;  1HY1 A;  4C5S A;  2QGA B;  1C3U A;  1K62 A;  2NYF A;  1C3C A;  1XLY A;  1U0L A;  3QBP A;  1XMC A;  4C6G A;  4BAA A;  4L57 A;  2VL7 A;  2PTR A;  1K7W A;  2O7D A;  1HY0 A;  3R6V A; 
#chains in the Genus database with same CATH homology
 2O7B A;  1GK3 A;  2YII A;  4NSL A;  1GK2 A;  3KDZ A;  3GTD A;  1XWO A;  5D6B A;  2VD6 A;  2X75 A;  4HGV A;  3KDY A;  2OHY A;  1TJW A;  4CQ5 A;  3RD8 A;  3C8T A;  3OCF A;  4V2R A;  5F92 A;  2NYN A;  4V2Q A;  1B8F A;  1FUO A;  1AUW A;  2QVE A;  3NO9 A;  2RJS A;  4NLE A;  2HVG A;  4FFX A;  1Q5N A;  3BHG A;  2PTS A;  3UNV A;  4ADL A;  4FLC A;  1RE5 A;  3GZH A;  4EEI A;  5EYT A;  1YFE A;  2O78 A;  1TJV A;  1VDK A;  1FUQ A;  3CZO A;  1KQ7 A;  2RJR A;  1I0A A;  1T6P A;  1GKJ A;  1W27 A;  1EB4 A;  2FUS A;  2E9F A;  1Y2M A;  1U16 A;  4APA A;  1JSW A;  1J3U A;  2O7F A;  5F91 A;  3TV2 A;  1U15 A;  3R6Q A;  1FUR A;  2PTQ A;  1TJU A;  4C5R A;  4ADM A;  3RRP A;  3E04 A;  5HW2 A;  4APB A;  1YIS A;  1T6J A;  1FUP A;  4EFC A;  1GKM A;  1TJ7 A;  3OCE A;  2O7E A;  3NZ4 A;  4MX2 A;  1DCN A;  2O6Y A;  4C5U A;  2J91 A;  3R6Y A;  1YFM A;  5EYV A;  4BAB A;  1DOF A;  2PFM A;  1HY1 A;  4C5S A;  2QGA B;  1C3U A;  1K62 A;  2NYF A;  1C3C A;  3QBP A;  4C6G A;  4BAA A;  2PTR A;  1K7W A;  2O7D A;  1HY0 A;  3R6V A; 
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