1DOFA

The crystal structure of adenylosuccinate lyase from pyrobaculum aerophilum: insights into thermal stability and human pathology
Total Genus 153
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
153
sequence length
402
structure length
385
Chain Sequence
HVSPFDWRYGSEEIRRLFTNEAIINAYLEVERALVCALEELGVAERGCCEKVNKASVSADEVHDILSLVLLLEQKSGCRYVHYGATSNDIIDTAWALLIRRALAAVKEKARAVGDQLASMARKYKTLEMVGRTHGQWAEPITLGFKFANYYYELYIACRQLALAEEFIRAKIGGAVGTMASWGELGLEVRRRVAERLGLPHHVITTQVAPRESFAVLASALALMAAVFERLAVEIRELSRPEIGEVVEGGANPTASERIVSLARYVRALTHVAFENVALWHERDLTNSANERVWIPEALLALDEILTSALRVLKNVYIDEERITENLQKALPYILTEFHMNRMIKEGASRAEAYKKAKEVKALTFEYQKWPVERLIEDALSLKLC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lyase
molecule keywords ADENYLOSUCCINATE LYASE
publication title The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds.
pubmed doi rcsb
source organism Pyrobaculum aerophilum
total genus 153
structure length 385
sequence length 402
chains with identical sequence B, C, D
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 1999-12-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 1dofA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1dofA02
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1dofA01
1T6PA 2O6YA 1T6JA 3QBPA 4MX2A 1GK2A 2E9FA 1W27A 1YFEA 1J3UA 4NLEA 1FURA 1HY0A 3E04A 1C3UA 4V2RA 3GZHA 2NYFA 4EEIA 2PTSA 3C8TA 2PFMA 5F92A 2PTQA 2PTRA 1Y2MA 1GKMA 1YISA 1TJWA 3OCEA 5EYTA 1KQ7A 1YFMA 5D6BA 1B8FA 1FUPA 1RE5A 4HGVA 1I0AA 2O7FA 4C5UA 1EB4A 2YIIA 1GK3A 1C3CA 2X75A 3NO9A 2O78A 1K7WA 3TV2A 3NZ4A 1FUOA 3GTDA 3R6QA 1TJ7A 1VDKA 4NSLA 4APBA 2QVEA 2VD6A 1JSWA 4C5SA 4EFCA 5F91A 3RRPA 1U16A 1TJVA 4ADMA 2O7BA 4FLCA 1K62A 4FFXA 4APAA 4V2QA 2QGAB 2NYNA 5EYVA 1U15A 3BHGA 2RJSA 1FUQA 1AUWA 3KDZA 1Q5NA 4ADLA 2RJRA 3R6YA 1HY1A 2OHYA 1DOFA 1GKJA 4C6GA 1DCNA 1XWOA 3UNVA 1TJUA 4C5RA 5HW2A 4CQ5A 3OCFA 2HVGA 4BABA 2FUSA 3RD8A 3CZOA 2O7EA 2J91A 3R6VA 4BAAA 3KDYA 2O7DA
chains in the Genus database with same CATH superfamily
1T6PA 2O6YA 2RCNA 4L57A 1T6JA 1Z4MA 3QBPA 4MX2A 1GK2A 1Z4QA 2E9FA 2VL7A 1W27A 1YFEA 1J3UA 4NLEA 1FURA 1HY0A 3E04A 3CRVA 1C3UA 4V2RA 4L6AA 3GZHA 2NYFA 5M0JA 1XLYA 4EEIA 1Z4PX 2PTSA 2PFMA 3C8TA 5F92A 2PTQA 2PTRA 2YV5A 1Z4IA 1GKMA 1Y2MA 1YISA 1TJWA 3OCEA 5EYTA 1KQ7A 1YFMA 4A15A 5D6BA 4IQJM 1B8FA 1FUPA 3F4RA 1RE5A 3F4SA 4HGVA 1I0AA 2O7FA 4C5UA 1EB4A 2YIIA 1GK3A 1C3CA 2X75A 3NO9A 2O78A 3CRW1 1K7WA 4NFLA 2JARA 3TV2A 1Q91A 2JAOA 3NZ4A 1FUOA 2D28C 3GTDA 1Z4LA 2VSFA 3R6QA 1TJ7A 1VDKA 4NSLA 4APBA 2QVEA 1IW7D 1XMCA 4E88A 2VD6A 3U19A 1JSWA 4C5SA 1Z4JA 4MUMA 4EFCA 5F91A 4L6CA 3CI0K 3RRPA 1U16A 1TJVA 4ADMA 2O7BA 4FLCA 1K62A 4FFXA 4YIHA 4APAA 4V2QA 2QGAB 3BWVA 2NYNA 5EYVA 1U15A 5M0IA 1XL7A 3BHGA 1XMDA 2RJSA 1FUQA 2I7DA 2D27A 4MWOA 1AUWA 1MH9A 1Q92A 3KDZA 1Z4KA 2FENA 1Q5NA 4ADLA 2RJRA 3R6YA 1HY1A 2OHYA 1U0LA 1DOFA 1GKJA 4C6GA 1DCNA 4WNLA 1XWOA 3UNVA 1T9HA 1TJUA 4YIKA 5H8WA 4C5RA 1XL8A 5HW2A 3F4TA 3OCFA 4CQ5A 2HVGA 4BABA 2FUSA 3RD8A 3CZOA 2JAWA 2O7EA 2J91A 3R6VA 4BAAA 2FELA 3U13A 3KDYA 2JAUA 2O7DA
chains in the Genus database with same CATH topology
1T6PA 2O6YA 1T6JA 3QBPA 4MX2A 1GK2A 2E9FA 1W27A 1YFEA 1J3UA 4NLEA 1FURA 1HY0A 3E04A 1C3UA 4V2RA 3GZHA 2NYFA 4EEIA 2PTSA 3C8TA 2PFMA 5F92A 2PTQA 2PTRA 1Y2MA 1GKMA 1YISA 1TJWA 3OCEA 5EYTA 1KQ7A 1YFMA 5D6BA 1B8FA 1FUPA 1RE5A 4HGVA 1I0AA 2O7FA 4C5UA 1EB4A 2YIIA 1GK3A 1C3CA 2X75A 3NO9A 2O78A 1K7WA 3TV2A 3NZ4A 1FUOA 3GTDA 3R6QA 1TJ7A 1VDKA 4NSLA 4APBA 2QVEA 2VD6A 1JSWA 4C5SA 4EFCA 5F91A 3RRPA 1U16A 1TJVA 4ADMA 2O7BA 4FLCA 1K62A 4FFXA 4APAA 4V2QA 2QGAB 2NYNA 5EYVA 1U15A 3BHGA 2RJSA 1FUQA 1AUWA 3KDZA 1Q5NA 4ADLA 2RJRA 3R6YA 1HY1A 2OHYA 1DOFA 1GKJA 4C6GA 1DCNA 1XWOA 3UNVA 1TJUA 4C5RA 5HW2A 4CQ5A 3OCFA 2HVGA 4BABA 2FUSA 3RD8A 3CZOA 2O7EA 2J91A 3R6VA 4BAAA 3KDYA 2O7DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1T6P A;  2O6Y A;  1T6J A;  3QBP A;  4MX2 A;  1GK2 A;  2E9F A;  1W27 A;  1YFE A;  1J3U A;  4NLE A;  1FUR A;  1HY0 A;  3E04 A;  1C3U A;  4V2R A;  3GZH A;  2NYF A;  4EEI A;  2PTS A;  3C8T A;  2PFM A;  5F92 A;  2PTQ A;  2PTR A;  1Y2M A;  1GKM A;  1YIS A;  1TJW A;  3OCE A;  5EYT A;  1KQ7 A;  1YFM A;  5D6B A;  1B8F A;  1FUP A;  1RE5 A;  4HGV A;  1I0A A;  2O7F A;  4C5U A;  1EB4 A;  2YII A;  1GK3 A;  1C3C A;  2X75 A;  3NO9 A;  2O78 A;  1K7W A;  3TV2 A;  3NZ4 A;  1FUO A;  3GTD A;  3R6Q A;  1TJ7 A;  1VDK A;  4NSL A;  4APB A;  2QVE A;  2VD6 A;  1JSW A;  4C5S A;  4EFC A;  5F91 A;  3RRP A;  1U16 A;  1TJV A;  4ADM A;  2O7B A;  4FLC A;  1K62 A;  4FFX A;  4APA A;  4V2Q A;  2QGA B;  2NYN A;  5EYV A;  1U15 A;  3BHG A;  2RJS A;  1FUQ A;  1AUW A;  3KDZ A;  1Q5N A;  4ADL A;  2RJR A;  3R6Y A;  1HY1 A;  2OHY A;  1DOF A;  1GKJ A;  4C6G A;  1DCN A;  1XWO A;  3UNV A;  1TJU A;  4C5R A;  5HW2 A;  4CQ5 A;  3OCF A;  2HVG A;  4BAB A;  2FUS A;  3RD8 A;  3CZO A;  2O7E A;  2J91 A;  3R6V A;  4BAA A;  3KDY A;  2O7D A; 
#chains in the Genus database with same CATH topology
 1T6P A;  2O6Y A;  2RCN A;  4L57 A;  1T6J A;  1Z4M A;  3QBP A;  4MX2 A;  1GK2 A;  1Z4Q A;  2E9F A;  2VL7 A;  1W27 A;  1YFE A;  1J3U A;  4NLE A;  1FUR A;  1HY0 A;  3E04 A;  3CRV A;  1C3U A;  4V2R A;  4L6A A;  3GZH A;  2NYF A;  5M0J A;  1XLY A;  4EEI A;  1Z4P X;  2PTS A;  2PFM A;  3C8T A;  5F92 A;  2PTQ A;  2PTR A;  2YV5 A;  1Z4I A;  1GKM A;  1Y2M A;  1YIS A;  1TJW A;  3OCE A;  5EYT A;  1KQ7 A;  1YFM A;  4A15 A;  5D6B A;  4IQJ M;  1B8F A;  1FUP A;  3F4R A;  1RE5 A;  3F4S A;  4HGV A;  1I0A A;  2O7F A;  4C5U A;  1EB4 A;  2YII A;  1GK3 A;  1C3C A;  2X75 A;  3NO9 A;  2O78 A;  3CRW 1;  1K7W A;  4NFL A;  2JAR A;  3TV2 A;  1Q91 A;  2JAO A;  3NZ4 A;  1FUO A;  2D28 C;  3GTD A;  1Z4L A;  2VSF A;  3R6Q A;  1TJ7 A;  1VDK A;  4NSL A;  4APB A;  2QVE A;  1IW7 D;  1XMC A;  4E88 A;  2VD6 A;  3U19 A;  1JSW A;  4C5S A;  1Z4J A;  4MUM A;  4EFC A;  5F91 A;  4L6C A;  3CI0 K;  3RRP A;  1U16 A;  1TJV A;  4ADM A;  2O7B A;  4FLC A;  1K62 A;  4FFX A;  4YIH A;  4APA A;  4V2Q A;  2QGA B;  3BWV A;  2NYN A;  5EYV A;  1U15 A;  5M0I A;  1XL7 A;  3BHG A;  1XMD A;  2RJS A;  1FUQ A;  2I7D A;  2D27 A;  4MWO A;  1AUW A;  1MH9 A;  1Q92 A;  3KDZ A;  1Z4K A;  2FEN A;  1Q5N A;  4ADL A;  2RJR A;  3R6Y A;  1HY1 A;  2OHY A;  1U0L A;  1DOF A;  1GKJ A;  4C6G A;  1DCN A;  4WNL A;  1XWO A;  3UNV A;  1T9H A;  1TJU A;  4YIK A;  5H8W A;  4C5R A;  1XL8 A;  5HW2 A;  3F4T A;  3OCF A;  4CQ5 A;  2HVG A;  4BAB A;  2FUS A;  3RD8 A;  3CZO A;  2JAW A;  2O7E A;  2J91 A;  3R6V A;  4BAA A;  2FEL A;  3U13 A;  3KDY A;  2JAU A;  2O7D A; 
#chains in the Genus database with same CATH homology
 1T6P A;  2O6Y A;  1T6J A;  3QBP A;  4MX2 A;  1GK2 A;  2E9F A;  1W27 A;  1YFE A;  1J3U A;  4NLE A;  1FUR A;  1HY0 A;  3E04 A;  1C3U A;  4V2R A;  3GZH A;  2NYF A;  4EEI A;  2PTS A;  3C8T A;  2PFM A;  5F92 A;  2PTQ A;  2PTR A;  1Y2M A;  1GKM A;  1YIS A;  1TJW A;  3OCE A;  5EYT A;  1KQ7 A;  1YFM A;  5D6B A;  1B8F A;  1FUP A;  1RE5 A;  4HGV A;  1I0A A;  2O7F A;  4C5U A;  1EB4 A;  2YII A;  1GK3 A;  1C3C A;  2X75 A;  3NO9 A;  2O78 A;  1K7W A;  3TV2 A;  3NZ4 A;  1FUO A;  3GTD A;  3R6Q A;  1TJ7 A;  1VDK A;  4NSL A;  4APB A;  2QVE A;  2VD6 A;  1JSW A;  4C5S A;  4EFC A;  5F91 A;  3RRP A;  1U16 A;  1TJV A;  4ADM A;  2O7B A;  4FLC A;  1K62 A;  4FFX A;  4APA A;  4V2Q A;  2QGA B;  2NYN A;  5EYV A;  1U15 A;  3BHG A;  2RJS A;  1FUQ A;  1AUW A;  3KDZ A;  1Q5N A;  4ADL A;  2RJR A;  3R6Y A;  1HY1 A;  2OHY A;  1DOF A;  1GKJ A;  4C6G A;  1DCN A;  1XWO A;  3UNV A;  1TJU A;  4C5R A;  5HW2 A;  4CQ5 A;  3OCF A;  2HVG A;  4BAB A;  2FUS A;  3RD8 A;  3CZO A;  2O7E A;  2J91 A;  3R6V A;  4BAA A;  3KDY A;  2O7D A; 
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