1DOFA

The crystal structure of adenylosuccinate lyase from pyrobaculum aerophilum: insights into thermal stability and human pathology
Total Genus 153
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
153
sequence length
402
structure length
385
Chain Sequence
HVSPFDWRYGSEEIRRLFTNEAIINAYLEVERALVCALEELGVAERGCCEKVNKASVSADEVHDILSLVLLLEQKSGCRYVHYGATSNDIIDTAWALLIRRALAAVKEKARAVGDQLASMARKYKTLEMVGRTHGQWAEPITLGFKFANYYYELYIACRQLALAEEFIRAKIGGAVGTMASWGELGLEVRRRVAERLGLPHHVITTQVAPRESFAVLASALALMAAVFERLAVEIRELSRPEIGEVVEGGANPTASERIVSLARYVRALTHVAFENVALWHERDLTNSANERVWIPEALLALDEILTSALRVLKNVYIDEERITENLQKALPYILTEFHMNRMIKEGASRAEAYKKAKEVKALTFEYQKWPVERLIEDALSLKLC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lyase
molecule keywords ADENYLOSUCCINATE LYASE
publication title The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds.
pubmed doi rcsb
source organism Pyrobaculum aerophilum
total genus 153
structure length 385
sequence length 402
chains with identical sequence B, C, D
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 1999-12-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 1dofA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1dofA02
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1dofA01
3GTDA 5F91A 3GZHA 3OCFA 4C5RA 1HY0A 1Q5NA 1RE5A 4CQ5A 1J3UA 1TJ7A 2E9FA 3TV2A 4EFCA 4V2QA 4C5UA 2HVGA 4EEIA 4C5SA 1HY1A 2RJRA 4ADMA 2O78A 3R6QA 3NO9A 3E04A 2OHYA 1FUPA 1EB4A 1C3CA 1FUOA 1XWOA 2NYNA 3CZOA 1VDKA 2O7DA 2O6YA 4FLCA 2O7FA 3UNVA 2RJSA 4APBA 1Y2MA 3R6VA 1FUQA 1U16A 1U15A 2YIIA 2QGAB 2NYFA 1KQ7A 1T6PA 3QBPA 5D6BA 4BAAA 1K7WA 3C8TA 1I0AA 1YISA 1DOFA 1TJVA 1DCNA 5F92A 2J91A 1YFEA 2QVEA 4BABA 1GKMA 5EYTA 1GK3A 2O7EA 2X75A 4ADLA 4FFXA 3RD8A 1JSWA 3NZ4A 1C3UA 4APAA 1GKJA 2PFMA 2PTQA 2PTRA 3RRPA 1TJUA 4NSLA 5HW2A 1B8FA 3BHGA 1GK2A 1AUWA 2PTSA 4MX2A 4NLEA 3OCEA 1K62A 5EYVA 4V2RA 1T6JA 2VD6A 1YFMA 2O7BA 2FUSA 3KDZA 1FURA 4HGVA 3KDYA 3R6YA 1TJWA 4C6GA 1W27A
chains in the Genus database with same CATH superfamily
1Z4MA 3BWVA 3GTDA 5F91A 2FELA 3GZHA 3OCFA 3CRW1 2VSFA 2FENA 3U13A 4C5RA 1HY0A 1Q5NA 3F4TA 1RE5A 4NFLA 4CQ5A 2RCNA 1J3UA 1TJ7A 2E9FA 3U19A 3TV2A 4EFCA 4V2QA 4C5UA 5H8WA 1Z4PX 4YIHA 2HVGA 1XMCA 5M0JA 4EEIA 4C5SA 2JAWA 1HY1A 2RJRA 4ADMA 2VL7A 1T9HA 2I7DA 2JAUA 2D28C 2O78A 3R6QA 3NO9A 3E04A 2OHYA 3F4RA 1FUPA 1EB4A 1C3CA 3CRVA 1FUOA 1XWOA 2NYNA 3CZOA 1VDKA 2O7DA 2O6YA 4FLCA 2O7FA 1Z4IA 3UNVA 2RJSA 4APBA 5M0IA 1XL8A 1Y2MA 3R6VA 1FUQA 1U16A 1U15A 2YIIA 2QGAB 2NYFA 1KQ7A 1T6PA 1Z4JA 4A15A 3QBPA 1MH9A 2JARA 5D6BA 1Z4KA 4BAAA 1Q91A 4L6CA 1K7WA 1XLYA 3C8TA 1I0AA 1YISA 1DOFA 1TJVA 4YIKA 1Z4LA 2D27A 1DCNA 5F92A 2J91A 2JAOA 1YFEA 2QVEA 4BABA 4L6AA 1Z4QA 1GKMA 5EYTA 4IQJM 1GK3A 2O7EA 2X75A 4ADLA 4FFXA 1XL7A 3RD8A 4WNLA 1JSWA 2YV5A 1C3UA 4APAA 3NZ4A 1GKJA 2PFMA 2PTQA 2PTRA 3RRPA 1TJUA 4NSLA 5HW2A 1B8FA 3CI0K 3BHGA 1GK2A 1IW7D 1AUWA 2PTSA 4MX2A 1U0LA 4NLEA 3OCEA 1K62A 5EYVA 4V2RA 1Q92A 1T6JA 4MWOA 4L57A 2VD6A 1YFMA 1XMDA 4E88A 2O7BA 2FUSA 3KDZA 1FURA 4MUMA 3F4SA 4HGVA 3KDYA 3R6YA 1TJWA 4C6GA 1W27A
chains in the Genus database with same CATH topology
3GTDA 5F91A 3GZHA 3OCFA 4C5RA 1HY0A 1Q5NA 1RE5A 4CQ5A 1J3UA 1TJ7A 2E9FA 3TV2A 4EFCA 4V2QA 4C5UA 2HVGA 4EEIA 4C5SA 1HY1A 2RJRA 4ADMA 2O78A 3R6QA 3NO9A 3E04A 2OHYA 1FUPA 1EB4A 1C3CA 1FUOA 1XWOA 2NYNA 3CZOA 1VDKA 2O7DA 2O6YA 4FLCA 2O7FA 3UNVA 2RJSA 4APBA 1Y2MA 3R6VA 1FUQA 1U16A 1U15A 2YIIA 2QGAB 2NYFA 1KQ7A 1T6PA 3QBPA 5D6BA 4BAAA 1K7WA 3C8TA 1I0AA 1YISA 1DOFA 1TJVA 1DCNA 5F92A 2J91A 1YFEA 2QVEA 4BABA 1GKMA 5EYTA 1GK3A 2O7EA 2X75A 4ADLA 4FFXA 3RD8A 1JSWA 3NZ4A 1C3UA 4APAA 1GKJA 2PFMA 2PTQA 2PTRA 3RRPA 1TJUA 4NSLA 5HW2A 1B8FA 3BHGA 1GK2A 1AUWA 2PTSA 4MX2A 4NLEA 3OCEA 1K62A 5EYVA 4V2RA 1T6JA 2VD6A 1YFMA 2O7BA 2FUSA 3KDZA 1FURA 4HGVA 3KDYA 3R6YA 1TJWA 4C6GA 1W27A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3GTD A;  5F91 A;  3GZH A;  3OCF A;  4C5R A;  1HY0 A;  1Q5N A;  1RE5 A;  4CQ5 A;  1J3U A;  1TJ7 A;  2E9F A;  3TV2 A;  4EFC A;  4V2Q A;  4C5U A;  2HVG A;  4EEI A;  4C5S A;  1HY1 A;  2RJR A;  4ADM A;  2O78 A;  3R6Q A;  3NO9 A;  3E04 A;  2OHY A;  1FUP A;  1EB4 A;  1C3C A;  1FUO A;  1XWO A;  2NYN A;  3CZO A;  1VDK A;  2O7D A;  2O6Y A;  4FLC A;  2O7F A;  3UNV A;  2RJS A;  4APB A;  1Y2M A;  3R6V A;  1FUQ A;  1U16 A;  1U15 A;  2YII A;  2QGA B;  2NYF A;  1KQ7 A;  1T6P A;  3QBP A;  5D6B A;  4BAA A;  1K7W A;  3C8T A;  1I0A A;  1YIS A;  1DOF A;  1TJV A;  1DCN A;  5F92 A;  2J91 A;  1YFE A;  2QVE A;  4BAB A;  1GKM A;  5EYT A;  1GK3 A;  2O7E A;  2X75 A;  4ADL A;  4FFX A;  3RD8 A;  1JSW A;  3NZ4 A;  1C3U A;  4APA A;  1GKJ A;  2PFM A;  2PTQ A;  2PTR A;  3RRP A;  1TJU A;  4NSL A;  5HW2 A;  1B8F A;  3BHG A;  1GK2 A;  1AUW A;  2PTS A;  4MX2 A;  4NLE A;  3OCE A;  1K62 A;  5EYV A;  4V2R A;  1T6J A;  2VD6 A;  1YFM A;  2O7B A;  2FUS A;  3KDZ A;  1FUR A;  4HGV A;  3KDY A;  3R6Y A;  1TJW A;  4C6G A;  1W27 A; 
#chains in the Genus database with same CATH topology
 1Z4M A;  3BWV A;  3GTD A;  5F91 A;  2FEL A;  3GZH A;  3OCF A;  3CRW 1;  2VSF A;  2FEN A;  3U13 A;  4C5R A;  1HY0 A;  1Q5N A;  3F4T A;  1RE5 A;  4NFL A;  4CQ5 A;  2RCN A;  1J3U A;  1TJ7 A;  2E9F A;  3U19 A;  3TV2 A;  4EFC A;  4V2Q A;  4C5U A;  5H8W A;  1Z4P X;  4YIH A;  2HVG A;  1XMC A;  5M0J A;  4EEI A;  4C5S A;  2JAW A;  1HY1 A;  2RJR A;  4ADM A;  2VL7 A;  1T9H A;  2I7D A;  2JAU A;  2D28 C;  2O78 A;  3R6Q A;  3NO9 A;  3E04 A;  2OHY A;  3F4R A;  1FUP A;  1EB4 A;  1C3C A;  3CRV A;  1FUO A;  1XWO A;  2NYN A;  3CZO A;  1VDK A;  2O7D A;  2O6Y A;  4FLC A;  2O7F A;  1Z4I A;  3UNV A;  2RJS A;  4APB A;  5M0I A;  1XL8 A;  1Y2M A;  3R6V A;  1FUQ A;  1U16 A;  1U15 A;  2YII A;  2QGA B;  2NYF A;  1KQ7 A;  1T6P A;  1Z4J A;  4A15 A;  3QBP A;  1MH9 A;  2JAR A;  5D6B A;  1Z4K A;  4BAA A;  1Q91 A;  4L6C A;  1K7W A;  1XLY A;  3C8T A;  1I0A A;  1YIS A;  1DOF A;  1TJV A;  4YIK A;  1Z4L A;  2D27 A;  1DCN A;  5F92 A;  2J91 A;  2JAO A;  1YFE A;  2QVE A;  4BAB A;  4L6A A;  1Z4Q A;  1GKM A;  5EYT A;  4IQJ M;  1GK3 A;  2O7E A;  2X75 A;  4ADL A;  4FFX A;  1XL7 A;  3RD8 A;  4WNL A;  1JSW A;  2YV5 A;  1C3U A;  4APA A;  3NZ4 A;  1GKJ A;  2PFM A;  2PTQ A;  2PTR A;  3RRP A;  1TJU A;  4NSL A;  5HW2 A;  1B8F A;  3CI0 K;  3BHG A;  1GK2 A;  1IW7 D;  1AUW A;  2PTS A;  4MX2 A;  1U0L A;  4NLE A;  3OCE A;  1K62 A;  5EYV A;  4V2R A;  1Q92 A;  1T6J A;  4MWO A;  4L57 A;  2VD6 A;  1YFM A;  1XMD A;  4E88 A;  2O7B A;  2FUS A;  3KDZ A;  1FUR A;  4MUM A;  3F4S A;  4HGV A;  3KDY A;  3R6Y A;  1TJW A;  4C6G A;  1W27 A; 
#chains in the Genus database with same CATH homology
 3GTD A;  5F91 A;  3GZH A;  3OCF A;  4C5R A;  1HY0 A;  1Q5N A;  1RE5 A;  4CQ5 A;  1J3U A;  1TJ7 A;  2E9F A;  3TV2 A;  4EFC A;  4V2Q A;  4C5U A;  2HVG A;  4EEI A;  4C5S A;  1HY1 A;  2RJR A;  4ADM A;  2O78 A;  3R6Q A;  3NO9 A;  3E04 A;  2OHY A;  1FUP A;  1EB4 A;  1C3C A;  1FUO A;  1XWO A;  2NYN A;  3CZO A;  1VDK A;  2O7D A;  2O6Y A;  4FLC A;  2O7F A;  3UNV A;  2RJS A;  4APB A;  1Y2M A;  3R6V A;  1FUQ A;  1U16 A;  1U15 A;  2YII A;  2QGA B;  2NYF A;  1KQ7 A;  1T6P A;  3QBP A;  5D6B A;  4BAA A;  1K7W A;  3C8T A;  1I0A A;  1YIS A;  1DOF A;  1TJV A;  1DCN A;  5F92 A;  2J91 A;  1YFE A;  2QVE A;  4BAB A;  1GKM A;  5EYT A;  1GK3 A;  2O7E A;  2X75 A;  4ADL A;  4FFX A;  3RD8 A;  1JSW A;  3NZ4 A;  1C3U A;  4APA A;  1GKJ A;  2PFM A;  2PTQ A;  2PTR A;  3RRP A;  1TJU A;  4NSL A;  5HW2 A;  1B8F A;  3BHG A;  1GK2 A;  1AUW A;  2PTS A;  4MX2 A;  4NLE A;  3OCE A;  1K62 A;  5EYV A;  4V2R A;  1T6J A;  2VD6 A;  1YFM A;  2O7B A;  2FUS A;  3KDZ A;  1FUR A;  4HGV A;  3KDY A;  3R6Y A;  1TJW A;  4C6G A;  1W27 A; 
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