1DOFA

The crystal structure of adenylosuccinate lyase from pyrobaculum aerophilum: insights into thermal stability and human pathology
Total Genus 153
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
153
sequence length
402
structure length
385
Chain Sequence
b'HVSPFDWRYGSEEIRRLFTNEAIINAYLEVERALVCALEELGVAERGCCEKVNKASVSADEVHDILSLVLLLEQKSGCRYVHYGATSNDIIDTAWALLIRRALAAVKEKARAVGDQLASMARKYKTLEMVGRTHGQWAEPITLGFKFANYYYELYIACRQLALAEEFIRAKIGGAVGTMASWGELGLEVRRRVAERLGLPHHVITTQVAPRESFAVLASALALMAAVFERLAVEIRELSRPEIGEVVEGGANPTASERIVSLARYVRALTHVAFENVALWHERDLTNSANERVWIPEALLALDEILTSALRVLKNVYIDEERITENLQKALPYILTEFHMNRMIKEGASRAEAYKKAKEVKALTFEYQKWPVERLIEDALSLKLC'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords ADENYLOSUCCINATE LYASE
publication title The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds.
pubmed doi rcsb
source organism Pyrobaculum aerophilum
molecule tags Lyase
total genus 153
structure length 385
sequence length 402
chains with identical sequence B, C, D
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 1999-12-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 1dofA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1dofA02
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1dofA01
2RJRA 1XWOA 2VD6A 2NYNA 1I0AA 1FURA 3RD8A 5F91A 3TV2A 1K62A 1DOFA 3GZHA 2PTRA 1HY1A 2X75A 1KQ7A 1JSWA 2QGAB 1Y2MA 1TJVA 4ADLA 1K7WA 1FUQA 3R6VA 1Q5NA 1AUWA 1GK2A 1YFEA 2YIIA 4FFXA 3BHGA 4BAAA 3R6QA 3KDZA 2PTSA 1GKJA 4C6GA 4APBA 2HVGA 2J91A 3E04A 1TJWA 4EEIA 1TJ7A 1FUOA 1EB4A 2OHYA 1GK3A 1HY0A 4V2QA 4APAA 1C3CA 1VDKA 5D6BA 3R6YA 2RJSA 4MX2A 3QBPA 2O78A 1T6PA 5EYVA 2NYFA 4C5UA 2O7DA 1B8FA 1U16A 2PTQA 4EFCA 3GTDA 5F92A 2O7EA 3CZOA 2PFMA 4C5RA 3RRPA 2FUSA 4FLCA 3OCEA 1U15A 4NLEA 1W27A 3NZ4A 4NSLA 1TJUA 3NO9A 2QVEA 3KDYA 1YFMA 1T6JA 4BABA 4C5SA 4CQ5A 1J3UA 1FUPA 2O6YA 3UNVA 1C3UA 5EYTA 4HGVA 2O7BA 3C8TA 3OCFA 1DCNA 1RE5A 2O7FA 4ADMA 1YISA 4V2RA 2E9FA 5HW2A 1GKMA
chains in the Genus database with same CATH superfamily
2RJRA 1XWOA 2VD6A 2FELA 2NYNA 1I0AA 1FURA 3RD8A 5F91A 3TV2A 4YIHA 3F4TA 1K62A 1Q92A 3CRVA 1DOFA 3GZHA 1MH9A 1HY1A 2PTRA 2X75A 1KQ7A 1JSWA 2QGAB 1Y2MA 1Z4LA 1TJVA 3BWVA 4ADLA 1K7WA 1XMCA 1FUQA 3R6VA 1Q5NA 2VL7A 2YV5A 1Z4JA 4MWOA 2D28C 1AUWA 1GK2A 4NFLA 1YFEA 1T9HA 4L57A 3F4RA 2YIIA 3F4SA 4FFXA 3BHGA 4BAAA 3R6QA 3KDZA 2PTSA 1GKJA 1XLYA 2JAOA 5M0IA 4C6GA 4APBA 2HVGA 2J91A 3E04A 3U19A 2JARA 1TJWA 4EEIA 1Z4KA 4IQJM 1TJ7A 1XMDA 1FUOA 1EB4A 4E88A 2OHYA 1GK3A 1HY0A 4V2QA 4APAA 1C3CA 1VDKA 5D6BA 3CI0K 3R6YA 2RJSA 4MX2A 3QBPA 5H8WA 2JAWA 2O78A 1T6PA 5EYVA 3U13A 2NYFA 4C5UA 2O7DA 1XL8A 1B8FA 1U16A 2PTQA 4EFCA 3GTDA 4MUMA 5F92A 3CRW1 4YIKA 2O7EA 2RCNA 3CZOA 2JAUA 2PFMA 4C5RA 3RRPA 2FUSA 4FLCA 3OCEA 1Z4IA 1U0LA 1U15A 1Z4QA 4NLEA 4L6CA 1W27A 3NZ4A 4NSLA 4WNLA 1TJUA 3NO9A 2QVEA 3KDYA 1YFMA 1T6JA 4BABA 1Z4PX 1Z4MA 4C5SA 1Q91A 4CQ5A 1J3UA 2VSFA 4L6AA 1FUPA 2I7DA 2O6YA 3UNVA 1XL7A 2D27A 4A15A 1IW7D 1C3UA 5EYTA 4HGVA 2O7BA 2FENA 3C8TA 3OCFA 1DCNA 1RE5A 2O7FA 4ADMA 1YISA 4V2RA 2E9FA 5HW2A 5M0JA 1GKMA
chains in the Genus database with same CATH topology
2RJRA 1XWOA 2VD6A 2NYNA 1I0AA 1FURA 3RD8A 5F91A 3TV2A 1K62A 1DOFA 3GZHA 2PTRA 1HY1A 2X75A 1KQ7A 1JSWA 2QGAB 1Y2MA 1TJVA 4ADLA 1K7WA 1FUQA 3R6VA 1Q5NA 1AUWA 1GK2A 1YFEA 2YIIA 4FFXA 3BHGA 4BAAA 3R6QA 3KDZA 2PTSA 1GKJA 4C6GA 4APBA 2HVGA 2J91A 3E04A 1TJWA 4EEIA 1TJ7A 1FUOA 1EB4A 2OHYA 1GK3A 1HY0A 4V2QA 4APAA 1C3CA 1VDKA 5D6BA 3R6YA 2RJSA 4MX2A 3QBPA 2O78A 1T6PA 5EYVA 2NYFA 4C5UA 2O7DA 1B8FA 1U16A 2PTQA 4EFCA 3GTDA 5F92A 2O7EA 3CZOA 2PFMA 4C5RA 3RRPA 2FUSA 4FLCA 3OCEA 1U15A 4NLEA 1W27A 3NZ4A 4NSLA 1TJUA 3NO9A 2QVEA 3KDYA 1YFMA 1T6JA 4BABA 4C5SA 4CQ5A 1J3UA 1FUPA 2O6YA 3UNVA 1C3UA 5EYTA 4HGVA 2O7BA 3C8TA 3OCFA 1DCNA 1RE5A 2O7FA 4ADMA 1YISA 4V2RA 2E9FA 5HW2A 1GKMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2RJR A;  1XWO A;  2VD6 A;  2NYN A;  1I0A A;  1FUR A;  3RD8 A;  5F91 A;  3TV2 A;  1K62 A;  1DOF A;  3GZH A;  2PTR A;  1HY1 A;  2X75 A;  1KQ7 A;  1JSW A;  2QGA B;  1Y2M A;  1TJV A;  4ADL A;  1K7W A;  1FUQ A;  3R6V A;  1Q5N A;  1AUW A;  1GK2 A;  1YFE A;  2YII A;  4FFX A;  3BHG A;  4BAA A;  3R6Q A;  3KDZ A;  2PTS A;  1GKJ A;  4C6G A;  4APB A;  2HVG A;  2J91 A;  3E04 A;  1TJW A;  4EEI A;  1TJ7 A;  1FUO A;  1EB4 A;  2OHY A;  1GK3 A;  1HY0 A;  4V2Q A;  4APA A;  1C3C A;  1VDK A;  5D6B A;  3R6Y A;  2RJS A;  4MX2 A;  3QBP A;  2O78 A;  1T6P A;  5EYV A;  2NYF A;  4C5U A;  2O7D A;  1B8F A;  1U16 A;  2PTQ A;  4EFC A;  3GTD A;  5F92 A;  2O7E A;  3CZO A;  2PFM A;  4C5R A;  3RRP A;  2FUS A;  4FLC A;  3OCE A;  1U15 A;  4NLE A;  1W27 A;  3NZ4 A;  4NSL A;  1TJU A;  3NO9 A;  2QVE A;  3KDY A;  1YFM A;  1T6J A;  4BAB A;  4C5S A;  4CQ5 A;  1J3U A;  1FUP A;  2O6Y A;  3UNV A;  1C3U A;  5EYT A;  4HGV A;  2O7B A;  3C8T A;  3OCF A;  1DCN A;  1RE5 A;  2O7F A;  4ADM A;  1YIS A;  4V2R A;  2E9F A;  5HW2 A;  1GKM A; 
#chains in the Genus database with same CATH topology
 2RJR A;  1XWO A;  2VD6 A;  2FEL A;  2NYN A;  1I0A A;  1FUR A;  3RD8 A;  5F91 A;  3TV2 A;  4YIH A;  3F4T A;  1K62 A;  1Q92 A;  3CRV A;  1DOF A;  3GZH A;  1MH9 A;  1HY1 A;  2PTR A;  2X75 A;  1KQ7 A;  1JSW A;  2QGA B;  1Y2M A;  1Z4L A;  1TJV A;  3BWV A;  4ADL A;  1K7W A;  1XMC A;  1FUQ A;  3R6V A;  1Q5N A;  2VL7 A;  2YV5 A;  1Z4J A;  4MWO A;  2D28 C;  1AUW A;  1GK2 A;  4NFL A;  1YFE A;  1T9H A;  4L57 A;  3F4R A;  2YII A;  3F4S A;  4FFX A;  3BHG A;  4BAA A;  3R6Q A;  3KDZ A;  2PTS A;  1GKJ A;  1XLY A;  2JAO A;  5M0I A;  4C6G A;  4APB A;  2HVG A;  2J91 A;  3E04 A;  3U19 A;  2JAR A;  1TJW A;  4EEI A;  1Z4K A;  4IQJ M;  1TJ7 A;  1XMD A;  1FUO A;  1EB4 A;  4E88 A;  2OHY A;  1GK3 A;  1HY0 A;  4V2Q A;  4APA A;  1C3C A;  1VDK A;  5D6B A;  3CI0 K;  3R6Y A;  2RJS A;  4MX2 A;  3QBP A;  5H8W A;  2JAW A;  2O78 A;  1T6P A;  5EYV A;  3U13 A;  2NYF A;  4C5U A;  2O7D A;  1XL8 A;  1B8F A;  1U16 A;  2PTQ A;  4EFC A;  3GTD A;  4MUM A;  5F92 A;  3CRW 1;  4YIK A;  2O7E A;  2RCN A;  3CZO A;  2JAU A;  2PFM A;  4C5R A;  3RRP A;  2FUS A;  4FLC A;  3OCE A;  1Z4I A;  1U0L A;  1U15 A;  1Z4Q A;  4NLE A;  4L6C A;  1W27 A;  3NZ4 A;  4NSL A;  4WNL A;  1TJU A;  3NO9 A;  2QVE A;  3KDY A;  1YFM A;  1T6J A;  4BAB A;  1Z4P X;  1Z4M A;  4C5S A;  1Q91 A;  4CQ5 A;  1J3U A;  2VSF A;  4L6A A;  1FUP A;  2I7D A;  2O6Y A;  3UNV A;  1XL7 A;  2D27 A;  4A15 A;  1IW7 D;  1C3U A;  5EYT A;  4HGV A;  2O7B A;  2FEN A;  3C8T A;  3OCF A;  1DCN A;  1RE5 A;  2O7F A;  4ADM A;  1YIS A;  4V2R A;  2E9F A;  5HW2 A;  5M0J A;  1GKM A; 
#chains in the Genus database with same CATH homology
 2RJR A;  1XWO A;  2VD6 A;  2NYN A;  1I0A A;  1FUR A;  3RD8 A;  5F91 A;  3TV2 A;  1K62 A;  1DOF A;  3GZH A;  2PTR A;  1HY1 A;  2X75 A;  1KQ7 A;  1JSW A;  2QGA B;  1Y2M A;  1TJV A;  4ADL A;  1K7W A;  1FUQ A;  3R6V A;  1Q5N A;  1AUW A;  1GK2 A;  1YFE A;  2YII A;  4FFX A;  3BHG A;  4BAA A;  3R6Q A;  3KDZ A;  2PTS A;  1GKJ A;  4C6G A;  4APB A;  2HVG A;  2J91 A;  3E04 A;  1TJW A;  4EEI A;  1TJ7 A;  1FUO A;  1EB4 A;  2OHY A;  1GK3 A;  1HY0 A;  4V2Q A;  4APA A;  1C3C A;  1VDK A;  5D6B A;  3R6Y A;  2RJS A;  4MX2 A;  3QBP A;  2O78 A;  1T6P A;  5EYV A;  2NYF A;  4C5U A;  2O7D A;  1B8F A;  1U16 A;  2PTQ A;  4EFC A;  3GTD A;  5F92 A;  2O7E A;  3CZO A;  2PFM A;  4C5R A;  3RRP A;  2FUS A;  4FLC A;  3OCE A;  1U15 A;  4NLE A;  1W27 A;  3NZ4 A;  4NSL A;  1TJU A;  3NO9 A;  2QVE A;  3KDY A;  1YFM A;  1T6J A;  4BAB A;  4C5S A;  4CQ5 A;  1J3U A;  1FUP A;  2O6Y A;  3UNV A;  1C3U A;  5EYT A;  4HGV A;  2O7B A;  3C8T A;  3OCF A;  1DCN A;  1RE5 A;  2O7F A;  4ADM A;  1YIS A;  4V2R A;  2E9F A;  5HW2 A;  1GKM A; 
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