1DOFA

The crystal structure of adenylosuccinate lyase from pyrobaculum aerophilum: insights into thermal stability and human pathology
Total Genus 153
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
153
sequence length
402
structure length
385
Chain Sequence
HVSPFDWRYGSEEIRRLFTNEAIINAYLEVERALVCALEELGVAERGCCEKVNKASVSADEVHDILSLVLLLEQKSGCRYVHYGATSNDIIDTAWALLIRRALAAVKEKARAVGDQLASMARKYKTLEMVGRTHGQWAEPITLGFKFANYYYELYIACRQLALAEEFIRAKIGGAVGTMASWGELGLEVRRRVAERLGLPHHVITTQVAPRESFAVLASALALMAAVFERLAVEIRELSRPEIGEVVEGGANPTASERIVSLARYVRALTHVAFENVALWHERDLTNSANERVWIPEALLALDEILTSALRVLKNVYIDEERITENLQKALPYILTEFHMNRMIKEGASRAEAYKKAKEVKALTFEYQKWPVERLIEDALSLKLC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords ADENYLOSUCCINATE LYASE
publication title The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds.
pubmed doi rcsb
source organism Pyrobaculum aerophilum
molecule tags Lyase
total genus 153
structure length 385
sequence length 402
chains with identical sequence B, C, D
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 1999-12-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 1dofA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1dofA02
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1dofA01
5F91A 1Q5NA 4ADLA 1K7WA 4V2QA 1TJUA 5EYTA 3NO9A 3KDYA 1JSWA 2J91A 1KQ7A 2HVGA 2PTQA 2O7BA 1HY0A 1EB4A 4NLEA 4NSLA 3CZOA 1TJWA 1GKJA 5HW2A 4C5UA 1RE5A 1TJVA 3RRPA 2PTSA 1GKMA 4HGVA 2YIIA 2PTRA 1B8FA 1GK2A 3TV2A 1Y2MA 4C6GA 3RD8A 4BABA 4APBA 3QBPA 4C5RA 2RJRA 4C5SA 4MX2A 1TJ7A 1FUQA 3OCFA 2O6YA 4EEIA 2QGAB 2O7EA 2FUSA 1I0AA 4V2RA 1YFEA 1GK3A 3OCEA 3GTDA 1J3UA 1U15A 4ADMA 4BAAA 2PFMA 5F92A 2RJSA 2O7FA 1T6JA 3KDZA 2NYNA 1DOFA 1YISA 1FUPA 3GZHA 2NYFA 2OHYA 4FLCA 1AUWA 1W27A 2E9FA 3BHGA 2QVEA 3R6VA 2O7DA 3UNVA 4FFXA 4EFCA 3C8TA 3R6YA 1FUOA 1YFMA 1HY1A 2O78A 3E04A 1XWOA 3R6QA 1C3UA 3NZ4A 5EYVA 1U16A 1C3CA 1VDKA 1DCNA 5D6BA 2X75A 4CQ5A 1FURA 1K62A 1T6PA 4APAA 2VD6A
chains in the Genus database with same CATH superfamily
1Z4KA 5F91A 1T9HA 1Q5NA 4ADLA 1XMDA 1K7WA 4V2QA 1TJUA 4A15A 5EYTA 3NO9A 3KDYA 1JSWA 4YIKA 2J91A 1KQ7A 2HVGA 2PTQA 2O7BA 1HY0A 1EB4A 4NLEA 4NSLA 1Z4PX 4IQJM 3CZOA 1XL8A 1TJWA 2FELA 1GKJA 5HW2A 4C5UA 1RE5A 1TJVA 3RRPA 2PTSA 1GKMA 1Z4LA 4HGVA 2YIIA 1Z4MA 2PTRA 1B8FA 2JAWA 1GK2A 3U13A 3TV2A 1Y2MA 3RD8A 4BABA 4C6GA 4APBA 3QBPA 4C5RA 1Z4IA 2RJRA 4C5SA 4MX2A 1TJ7A 1FUQA 3OCFA 1Z4JA 2O6YA 2I7DA 4EEIA 2QGAB 2O7EA 2FUSA 3CRVA 4L57A 1I0AA 4V2RA 3U19A 4E88A 1YFEA 1GK3A 1XL7A 1Z4QA 3OCEA 1XMCA 3GTDA 1J3UA 1U15A 4ADMA 4L6AA 4BAAA 3CRW1 2JARA 2PFMA 5F92A 4MUMA 2RJSA 2O7FA 1T6JA 3KDZA 2NYNA 1DOFA 3BWVA 1YISA 2JAOA 1FUPA 1Q92A 5M0IA 3GZHA 4YIHA 2D27A 2NYFA 2OHYA 4FLCA 1IW7D 1U0LA 1AUWA 3CI0K 4WNLA 1W27A 2VL7A 2E9FA 3BHGA 2QVEA 3R6VA 2O7DA 3UNVA 4FFXA 4EFCA 3C8TA 3R6YA 1FUOA 3F4TA 1YFMA 1HY1A 4MWOA 5H8WA 2O78A 4L6CA 2RCNA 2VSFA 3F4RA 3E04A 1XWOA 2FENA 3R6QA 1C3UA 3NZ4A 3F4SA 5EYVA 1U16A 2JAUA 1XLYA 1C3CA 1MH9A 1VDKA 1DCNA 5D6BA 2X75A 2D28C 5M0JA 4NFLA 4CQ5A 1FURA 1K62A 1T6PA 2YV5A 1Q91A 4APAA 2VD6A
chains in the Genus database with same CATH topology
5F91A 1Q5NA 4ADLA 1K7WA 4V2QA 1TJUA 5EYTA 3NO9A 3KDYA 1JSWA 2J91A 1KQ7A 2HVGA 2PTQA 2O7BA 1HY0A 1EB4A 4NLEA 4NSLA 3CZOA 1TJWA 1GKJA 5HW2A 4C5UA 1RE5A 1TJVA 3RRPA 2PTSA 1GKMA 4HGVA 2YIIA 2PTRA 1B8FA 1GK2A 3TV2A 1Y2MA 4C6GA 3RD8A 4BABA 4APBA 3QBPA 4C5RA 2RJRA 4C5SA 4MX2A 1TJ7A 1FUQA 3OCFA 2O6YA 4EEIA 2QGAB 2O7EA 2FUSA 1I0AA 4V2RA 1YFEA 1GK3A 3OCEA 3GTDA 1J3UA 1U15A 4ADMA 4BAAA 2PFMA 5F92A 2RJSA 2O7FA 1T6JA 3KDZA 2NYNA 1DOFA 1YISA 1FUPA 3GZHA 2NYFA 2OHYA 4FLCA 1AUWA 1W27A 2E9FA 3BHGA 2QVEA 3R6VA 2O7DA 3UNVA 4FFXA 4EFCA 3C8TA 3R6YA 1FUOA 1YFMA 1HY1A 2O78A 3E04A 1XWOA 3R6QA 1C3UA 3NZ4A 5EYVA 1U16A 1C3CA 1VDKA 1DCNA 5D6BA 2X75A 4CQ5A 1FURA 1K62A 1T6PA 4APAA 2VD6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5F91 A;  1Q5N A;  4ADL A;  1K7W A;  4V2Q A;  1TJU A;  5EYT A;  3NO9 A;  3KDY A;  1JSW A;  2J91 A;  1KQ7 A;  2HVG A;  2PTQ A;  2O7B A;  1HY0 A;  1EB4 A;  4NLE A;  4NSL A;  3CZO A;  1TJW A;  1GKJ A;  5HW2 A;  4C5U A;  1RE5 A;  1TJV A;  3RRP A;  2PTS A;  1GKM A;  4HGV A;  2YII A;  2PTR A;  1B8F A;  1GK2 A;  3TV2 A;  1Y2M A;  4C6G A;  3RD8 A;  4BAB A;  4APB A;  3QBP A;  4C5R A;  2RJR A;  4C5S A;  4MX2 A;  1TJ7 A;  1FUQ A;  3OCF A;  2O6Y A;  4EEI A;  2QGA B;  2O7E A;  2FUS A;  1I0A A;  4V2R A;  1YFE A;  1GK3 A;  3OCE A;  3GTD A;  1J3U A;  1U15 A;  4ADM A;  4BAA A;  2PFM A;  5F92 A;  2RJS A;  2O7F A;  1T6J A;  3KDZ A;  2NYN A;  1DOF A;  1YIS A;  1FUP A;  3GZH A;  2NYF A;  2OHY A;  4FLC A;  1AUW A;  1W27 A;  2E9F A;  3BHG A;  2QVE A;  3R6V A;  2O7D A;  3UNV A;  4FFX A;  4EFC A;  3C8T A;  3R6Y A;  1FUO A;  1YFM A;  1HY1 A;  2O78 A;  3E04 A;  1XWO A;  3R6Q A;  1C3U A;  3NZ4 A;  5EYV A;  1U16 A;  1C3C A;  1VDK A;  1DCN A;  5D6B A;  2X75 A;  4CQ5 A;  1FUR A;  1K62 A;  1T6P A;  4APA A;  2VD6 A; 
#chains in the Genus database with same CATH topology
 1Z4K A;  5F91 A;  1T9H A;  1Q5N A;  4ADL A;  1XMD A;  1K7W A;  4V2Q A;  1TJU A;  4A15 A;  5EYT A;  3NO9 A;  3KDY A;  1JSW A;  4YIK A;  2J91 A;  1KQ7 A;  2HVG A;  2PTQ A;  2O7B A;  1HY0 A;  1EB4 A;  4NLE A;  4NSL A;  1Z4P X;  4IQJ M;  3CZO A;  1XL8 A;  1TJW A;  2FEL A;  1GKJ A;  5HW2 A;  4C5U A;  1RE5 A;  1TJV A;  3RRP A;  2PTS A;  1GKM A;  1Z4L A;  4HGV A;  2YII A;  1Z4M A;  2PTR A;  1B8F A;  2JAW A;  1GK2 A;  3U13 A;  3TV2 A;  1Y2M A;  3RD8 A;  4BAB A;  4C6G A;  4APB A;  3QBP A;  4C5R A;  1Z4I A;  2RJR A;  4C5S A;  4MX2 A;  1TJ7 A;  1FUQ A;  3OCF A;  1Z4J A;  2O6Y A;  2I7D A;  4EEI A;  2QGA B;  2O7E A;  2FUS A;  3CRV A;  4L57 A;  1I0A A;  4V2R A;  3U19 A;  4E88 A;  1YFE A;  1GK3 A;  1XL7 A;  1Z4Q A;  3OCE A;  1XMC A;  3GTD A;  1J3U A;  1U15 A;  4ADM A;  4L6A A;  4BAA A;  3CRW 1;  2JAR A;  2PFM A;  5F92 A;  4MUM A;  2RJS A;  2O7F A;  1T6J A;  3KDZ A;  2NYN A;  1DOF A;  3BWV A;  1YIS A;  2JAO A;  1FUP A;  1Q92 A;  5M0I A;  3GZH A;  4YIH A;  2D27 A;  2NYF A;  2OHY A;  4FLC A;  1IW7 D;  1U0L A;  1AUW A;  3CI0 K;  4WNL A;  1W27 A;  2VL7 A;  2E9F A;  3BHG A;  2QVE A;  3R6V A;  2O7D A;  3UNV A;  4FFX A;  4EFC A;  3C8T A;  3R6Y A;  1FUO A;  3F4T A;  1YFM A;  1HY1 A;  4MWO A;  5H8W A;  2O78 A;  4L6C A;  2RCN A;  2VSF A;  3F4R A;  3E04 A;  1XWO A;  2FEN A;  3R6Q A;  1C3U A;  3NZ4 A;  3F4S A;  5EYV A;  1U16 A;  2JAU A;  1XLY A;  1C3C A;  1MH9 A;  1VDK A;  1DCN A;  5D6B A;  2X75 A;  2D28 C;  5M0J A;  4NFL A;  4CQ5 A;  1FUR A;  1K62 A;  1T6P A;  2YV5 A;  1Q91 A;  4APA A;  2VD6 A; 
#chains in the Genus database with same CATH homology
 5F91 A;  1Q5N A;  4ADL A;  1K7W A;  4V2Q A;  1TJU A;  5EYT A;  3NO9 A;  3KDY A;  1JSW A;  2J91 A;  1KQ7 A;  2HVG A;  2PTQ A;  2O7B A;  1HY0 A;  1EB4 A;  4NLE A;  4NSL A;  3CZO A;  1TJW A;  1GKJ A;  5HW2 A;  4C5U A;  1RE5 A;  1TJV A;  3RRP A;  2PTS A;  1GKM A;  4HGV A;  2YII A;  2PTR A;  1B8F A;  1GK2 A;  3TV2 A;  1Y2M A;  4C6G A;  3RD8 A;  4BAB A;  4APB A;  3QBP A;  4C5R A;  2RJR A;  4C5S A;  4MX2 A;  1TJ7 A;  1FUQ A;  3OCF A;  2O6Y A;  4EEI A;  2QGA B;  2O7E A;  2FUS A;  1I0A A;  4V2R A;  1YFE A;  1GK3 A;  3OCE A;  3GTD A;  1J3U A;  1U15 A;  4ADM A;  4BAA A;  2PFM A;  5F92 A;  2RJS A;  2O7F A;  1T6J A;  3KDZ A;  2NYN A;  1DOF A;  1YIS A;  1FUP A;  3GZH A;  2NYF A;  2OHY A;  4FLC A;  1AUW A;  1W27 A;  2E9F A;  3BHG A;  2QVE A;  3R6V A;  2O7D A;  3UNV A;  4FFX A;  4EFC A;  3C8T A;  3R6Y A;  1FUO A;  1YFM A;  1HY1 A;  2O78 A;  3E04 A;  1XWO A;  3R6Q A;  1C3U A;  3NZ4 A;  5EYV A;  1U16 A;  1C3C A;  1VDK A;  1DCN A;  5D6B A;  2X75 A;  4CQ5 A;  1FUR A;  1K62 A;  1T6P A;  4APA A;  2VD6 A; 
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