4ADLA

Crystal structures of rv1098c in complex with malate
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
sequence length
459
structure length
459
Chain Sequence
NYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Lyase
molecule keywords FUMARATE HYDRATASE CLASS II
total genus 177
structure length 459
sequence length 459
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2011-12-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4adlA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4adlA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4adlA02
3R6VA 2HVGA 4ADMA 1XWOA 3R6QA 1FURA 2YIIA 2PFMA 2NYNA 3RRPA 1YFEA 4EFCA 1GK3A 1TJWA 3GZHA 2RJRA 4BABA 1AUWA 1T6PA 1FUPA 3QBPA 5F91A 1EB4A 4V2RA 3BHGA 1RE5A 2FUSA 1GKMA 3OCFA 1J3UA 3OCEA 1HY1A 4FFXA 1K62A 5EYTA 1K7WA 2O78A 3GTDA 1W27A 3TV2A 4CQ5A 2VD6A 1TJ7A 1FUOA 4V2QA 1VDKA 4HGVA 4C5RA 1TJVA 2O6YA 2QGAB 3RD8A 5EYVA 3E04A 2J91A 2QVEA 3KDZA 4ADLA 1DCNA 2O7FA 4NLEA 2X75A 5HW2A 1Y2MA 1YFMA 4C5UA 2O7DA 1FUQA 1Q5NA 4BAAA 4C6GA 2O7EA 2PTQA 1U15A 2E9FA 3C8TA 1I0AA 1GK2A 2NYFA 1C3CA 4FLCA 4MX2A 3UNVA 3CZOA 1B8FA 1YISA 1DOFA 2O7BA 4C5SA 4APAA 5F92A 2RJSA 1HY0A 1U16A 5D6BA 1TJUA 1T6JA 3NO9A 2PTSA 1C3UA 3NZ4A 4APBA 1GKJA 1JSWA 1KQ7A 3KDYA 3R6YA 2PTRA 2OHYA 4EEIA 4NSLA
chains in the Genus database with same CATH superfamily
3R6VA 1Z4MA 2HVGA 4ADMA 1Z4LA 1XWOA 3R6QA 1FURA 2JAUA 2JAWA 2YIIA 2PFMA 2D27A 2NYNA 1Q92A 4MWOA 3RRPA 1YFEA 4EFCA 1GK3A 1TJWA 3GZHA 3U19A 2RJRA 1XL7A 1IW7D 4BABA 1AUWA 1T6PA 1FUPA 3BWVA 3QBPA 4L6CA 5F91A 1EB4A 4V2RA 3BHGA 3CRVA 1RE5A 2FUSA 1Z4JA 1T9HA 1Z4KA 4E88A 1GKMA 3OCFA 3CRW1 1J3UA 4YIKA 1XMCA 1XLYA 5M0JA 3OCEA 1HY1A 4FFXA 5H8WA 1K62A 5EYTA 1K7WA 2O78A 2FELA 3GTDA 1W27A 3TV2A 4CQ5A 2VD6A 2VL7A 1TJ7A 3F4SA 4IQJM 1FUOA 4V2QA 1VDKA 4HGVA 1Q91A 4C5RA 1TJVA 1XMDA 2O6YA 2QGAB 3RD8A 2YV5A 5EYVA 3U13A 5M0IA 3E04A 2J91A 2QVEA 1XL8A 3KDZA 4ADLA 1DCNA 2JARA 2O7FA 4NLEA 2X75A 5HW2A 1Y2MA 1YFMA 4C5UA 2O7DA 4WNLA 1FUQA 1Q5NA 4BAAA 4C6GA 4L6AA 2PTQA 1U15A 1Z4IA 2E9FA 3C8TA 2O7EA 4MUMA 1MH9A 3CI0K 1I0AA 2D28C 1GK2A 2VSFA 3F4RA 2NYFA 1C3CA 4L57A 4MX2A 4FLCA 3UNVA 4YIHA 3CZOA 4A15A 1B8FA 2FENA 2JAOA 1YISA 1DOFA 2O7BA 4C5SA 4APAA 5F92A 2RJSA 1HY0A 1U16A 5D6BA 1TJUA 1T6JA 3NO9A 2RCNA 1Z4QA 2PTSA 1Z4PX 1C3UA 3NZ4A 4APBA 1U0LA 1GKJA 4NFLA 1JSWA 1KQ7A 3KDYA 3R6YA 2PTRA 2OHYA 2I7DA 3F4TA 4EEIA 4NSLA
chains in the Genus database with same CATH topology
3R6VA 2HVGA 4ADMA 1XWOA 3R6QA 1FURA 2YIIA 2PFMA 2NYNA 3RRPA 1YFEA 4EFCA 1GK3A 1TJWA 3GZHA 2RJRA 4BABA 1AUWA 1T6PA 1FUPA 3QBPA 5F91A 1EB4A 4V2RA 3BHGA 1RE5A 2FUSA 1GKMA 3OCFA 1J3UA 3OCEA 1HY1A 4FFXA 1K62A 5EYTA 1K7WA 2O78A 3GTDA 1W27A 3TV2A 4CQ5A 2VD6A 1TJ7A 1FUOA 4V2QA 1VDKA 4HGVA 4C5RA 1TJVA 2O6YA 2QGAB 3RD8A 5EYVA 3E04A 2J91A 2QVEA 3KDZA 4ADLA 1DCNA 2O7FA 4NLEA 2X75A 5HW2A 1Y2MA 1YFMA 4C5UA 2O7DA 1FUQA 1Q5NA 4BAAA 4C6GA 2O7EA 2PTQA 1U15A 2E9FA 3C8TA 1I0AA 1GK2A 2NYFA 1C3CA 4FLCA 4MX2A 3UNVA 3CZOA 1B8FA 1YISA 1DOFA 2O7BA 4C5SA 4APAA 5F92A 2RJSA 1HY0A 1U16A 5D6BA 1TJUA 1T6JA 3NO9A 2PTSA 1C3UA 3NZ4A 4APBA 1GKJA 1JSWA 1KQ7A 3KDYA 3R6YA 2PTRA 2OHYA 4EEIA 4NSLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3R6V A;  2HVG A;  4ADM A;  1XWO A;  3R6Q A;  1FUR A;  2YII A;  2PFM A;  2NYN A;  3RRP A;  1YFE A;  4EFC A;  1GK3 A;  1TJW A;  3GZH A;  2RJR A;  4BAB A;  1AUW A;  1T6P A;  1FUP A;  3QBP A;  5F91 A;  1EB4 A;  4V2R A;  3BHG A;  1RE5 A;  2FUS A;  1GKM A;  3OCF A;  1J3U A;  3OCE A;  1HY1 A;  4FFX A;  1K62 A;  5EYT A;  1K7W A;  2O78 A;  3GTD A;  1W27 A;  3TV2 A;  4CQ5 A;  2VD6 A;  1TJ7 A;  1FUO A;  4V2Q A;  1VDK A;  4HGV A;  4C5R A;  1TJV A;  2O6Y A;  2QGA B;  3RD8 A;  5EYV A;  3E04 A;  2J91 A;  2QVE A;  3KDZ A;  4ADL A;  1DCN A;  2O7F A;  4NLE A;  2X75 A;  5HW2 A;  1Y2M A;  1YFM A;  4C5U A;  2O7D A;  1FUQ A;  1Q5N A;  4BAA A;  4C6G A;  2O7E A;  2PTQ A;  1U15 A;  2E9F A;  3C8T A;  1I0A A;  1GK2 A;  2NYF A;  1C3C A;  4FLC A;  4MX2 A;  3UNV A;  3CZO A;  1B8F A;  1YIS A;  1DOF A;  2O7B A;  4C5S A;  4APA A;  5F92 A;  2RJS A;  1HY0 A;  1U16 A;  5D6B A;  1TJU A;  1T6J A;  3NO9 A;  2PTS A;  1C3U A;  3NZ4 A;  4APB A;  1GKJ A;  1JSW A;  1KQ7 A;  3KDY A;  3R6Y A;  2PTR A;  2OHY A;  4EEI A;  4NSL A; 
#chains in the Genus database with same CATH topology
 3R6V A;  1Z4M A;  2HVG A;  4ADM A;  1Z4L A;  1XWO A;  3R6Q A;  1FUR A;  2JAU A;  2JAW A;  2YII A;  2PFM A;  2D27 A;  2NYN A;  1Q92 A;  4MWO A;  3RRP A;  1YFE A;  4EFC A;  1GK3 A;  1TJW A;  3GZH A;  3U19 A;  2RJR A;  1XL7 A;  1IW7 D;  4BAB A;  1AUW A;  1T6P A;  1FUP A;  3BWV A;  3QBP A;  4L6C A;  5F91 A;  1EB4 A;  4V2R A;  3BHG A;  3CRV A;  1RE5 A;  2FUS A;  1Z4J A;  1T9H A;  1Z4K A;  4E88 A;  1GKM A;  3OCF A;  3CRW 1;  1J3U A;  4YIK A;  1XMC A;  1XLY A;  5M0J A;  3OCE A;  1HY1 A;  4FFX A;  5H8W A;  1K62 A;  5EYT A;  1K7W A;  2O78 A;  2FEL A;  3GTD A;  1W27 A;  3TV2 A;  4CQ5 A;  2VD6 A;  2VL7 A;  1TJ7 A;  3F4S A;  4IQJ M;  1FUO A;  4V2Q A;  1VDK A;  4HGV A;  1Q91 A;  4C5R A;  1TJV A;  1XMD A;  2O6Y A;  2QGA B;  3RD8 A;  2YV5 A;  5EYV A;  3U13 A;  5M0I A;  3E04 A;  2J91 A;  2QVE A;  1XL8 A;  3KDZ A;  4ADL A;  1DCN A;  2JAR A;  2O7F A;  4NLE A;  2X75 A;  5HW2 A;  1Y2M A;  1YFM A;  4C5U A;  2O7D A;  4WNL A;  1FUQ A;  1Q5N A;  4BAA A;  4C6G A;  4L6A A;  2PTQ A;  1U15 A;  1Z4I A;  2E9F A;  3C8T A;  2O7E A;  4MUM A;  1MH9 A;  3CI0 K;  1I0A A;  2D28 C;  1GK2 A;  2VSF A;  3F4R A;  2NYF A;  1C3C A;  4L57 A;  4MX2 A;  4FLC A;  3UNV A;  4YIH A;  3CZO A;  4A15 A;  1B8F A;  2FEN A;  2JAO A;  1YIS A;  1DOF A;  2O7B A;  4C5S A;  4APA A;  5F92 A;  2RJS A;  1HY0 A;  1U16 A;  5D6B A;  1TJU A;  1T6J A;  3NO9 A;  2RCN A;  1Z4Q A;  2PTS A;  1Z4P X;  1C3U A;  3NZ4 A;  4APB A;  1U0L A;  1GKJ A;  4NFL A;  1JSW A;  1KQ7 A;  3KDY A;  3R6Y A;  2PTR A;  2OHY A;  2I7D A;  3F4T A;  4EEI A;  4NSL A; 
#chains in the Genus database with same CATH homology
 3R6V A;  2HVG A;  4ADM A;  1XWO A;  3R6Q A;  1FUR A;  2YII A;  2PFM A;  2NYN A;  3RRP A;  1YFE A;  4EFC A;  1GK3 A;  1TJW A;  3GZH A;  2RJR A;  4BAB A;  1AUW A;  1T6P A;  1FUP A;  3QBP A;  5F91 A;  1EB4 A;  4V2R A;  3BHG A;  1RE5 A;  2FUS A;  1GKM A;  3OCF A;  1J3U A;  3OCE A;  1HY1 A;  4FFX A;  1K62 A;  5EYT A;  1K7W A;  2O78 A;  3GTD A;  1W27 A;  3TV2 A;  4CQ5 A;  2VD6 A;  1TJ7 A;  1FUO A;  4V2Q A;  1VDK A;  4HGV A;  4C5R A;  1TJV A;  2O6Y A;  2QGA B;  3RD8 A;  5EYV A;  3E04 A;  2J91 A;  2QVE A;  3KDZ A;  4ADL A;  1DCN A;  2O7F A;  4NLE A;  2X75 A;  5HW2 A;  1Y2M A;  1YFM A;  4C5U A;  2O7D A;  1FUQ A;  1Q5N A;  4BAA A;  4C6G A;  2O7E A;  2PTQ A;  1U15 A;  2E9F A;  3C8T A;  1I0A A;  1GK2 A;  2NYF A;  1C3C A;  4FLC A;  4MX2 A;  3UNV A;  3CZO A;  1B8F A;  1YIS A;  1DOF A;  2O7B A;  4C5S A;  4APA A;  5F92 A;  2RJS A;  1HY0 A;  1U16 A;  5D6B A;  1TJU A;  1T6J A;  3NO9 A;  2PTS A;  1C3U A;  3NZ4 A;  4APB A;  1GKJ A;  1JSW A;  1KQ7 A;  3KDY A;  3R6Y A;  2PTR A;  2OHY A;  4EEI A;  4NSL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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