4ADLA

Crystal structures of rv1098c in complex with malate
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
sequence length
459
structure length
459
Chain Sequence
NYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords FUMARATE HYDRATASE CLASS II
publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Lyase
total genus 177
structure length 459
sequence length 459
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2011-12-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4adlA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4adlA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4adlA02
2FUSA 2O6YA 4NSLA 1Y2MA 1U16A 5EYTA 3GTDA 2O7DA 3BHGA 1FUQA 1TJWA 1TJ7A 2QGAB 5EYVA 5HW2A 2NYNA 4C6GA 2YIIA 3RRPA 1FURA 5F92A 1J3UA 3OCFA 4ADMA 2O7EA 1GKJA 1KQ7A 1RE5A 4CQ5A 4FFXA 1VDKA 3UNVA 3CZOA 2O7FA 4BABA 3NZ4A 4BAAA 2X75A 1YFEA 1K7WA 3RD8A 3GZHA 4APAA 1HY0A 3R6QA 2PTQA 3C8TA 4ADLA 3KDYA 1EB4A 3TV2A 1T6PA 1C3CA 4V2QA 2RJSA 4C5UA 1GK2A 1FUOA 5F91A 1HY1A 1GKMA 4C5SA 1B8FA 2OHYA 1Q5NA 1DOFA 1T6JA 3QBPA 5D6BA 2E9FA 4V2RA 1FUPA 3R6YA 1YISA 1I0AA 1XWOA 2HVGA 4MX2A 3KDZA 1JSWA 4APBA 2PFMA 1C3UA 4EEIA 2VD6A 1U15A 3NO9A 4FLCA 3OCEA 1K62A 4NLEA 4EFCA 2O78A 2PTSA 4C5RA 2RJRA 1W27A 2O7BA 2NYFA 1YFMA 4HGVA 2J91A 1GK3A 1TJUA 1AUWA 2PTRA 3E04A 3R6VA 1TJVA 2QVEA 1DCNA
chains in the Genus database with same CATH superfamily
2FUSA 2O6YA 1Z4JA 4NSLA 4MWOA 1Y2MA 1U16A 2JAUA 5EYTA 1U0LA 3GTDA 2O7DA 3BHGA 1FUQA 4NFLA 1XMCA 1TJWA 4L57A 1TJ7A 2QGAB 5EYVA 3U19A 2D27A 5HW2A 1Q92A 1XL7A 2NYNA 1XLYA 4C6GA 2YIIA 5M0JA 3RRPA 1FURA 5F92A 1XMDA 1J3UA 3OCFA 4ADMA 4E88A 3BWVA 4YIHA 2O7EA 1GKJA 1KQ7A 1RE5A 1XL8A 3F4TA 4FFXA 4CQ5A 3U13A 1VDKA 3UNVA 3CZOA 2O7FA 4BABA 1Z4MA 3NZ4A 4BAAA 2X75A 1T9HA 1YFEA 1K7WA 3RD8A 3GZHA 4APAA 1HY0A 3F4SA 3R6QA 2PTQA 3C8TA 4ADLA 3KDYA 1Z4QA 1EB4A 3TV2A 2D28C 1T6PA 1C3CA 4V2QA 2RJSA 4IQJM 4C5UA 1GK2A 1FUOA 4A15A 5H8WA 5F91A 1HY1A 1GKMA 4C5SA 2VSFA 1B8FA 2OHYA 1Q5NA 3CRVA 1DOFA 1T6JA 5M0IA 3F4RA 1IW7D 2FELA 3QBPA 5D6BA 2E9FA 4V2RA 1FUPA 3R6YA 2JARA 4MUMA 1YISA 1I0AA 1XWOA 1Z4KA 2HVGA 4MX2A 3KDZA 2YV5A 4L6CA 1Z4IA 1JSWA 4APBA 2PFMA 2I7DA 1MH9A 4WNLA 1C3UA 4EEIA 2VD6A 1U15A 3NO9A 1Z4LA 4FLCA 2JAWA 3OCEA 1K62A 4NLEA 4EFCA 2O78A 2PTSA 1Z4PX 3CRW1 2FENA 4C5RA 2RJRA 1W27A 2RCNA 2O7BA 2NYFA 1YFMA 4HGVA 2J91A 1GK3A 1Q91A 4L6AA 3CI0K 1TJUA 1AUWA 2PTRA 3E04A 4YIKA 3R6VA 1TJVA 2JAOA 2QVEA 2VL7A 1DCNA
chains in the Genus database with same CATH topology
2FUSA 2O6YA 4NSLA 1Y2MA 1U16A 5EYTA 3GTDA 2O7DA 3BHGA 1FUQA 1TJWA 1TJ7A 2QGAB 5EYVA 5HW2A 2NYNA 4C6GA 2YIIA 3RRPA 1FURA 5F92A 1J3UA 3OCFA 4ADMA 2O7EA 1GKJA 1KQ7A 1RE5A 4CQ5A 4FFXA 1VDKA 3UNVA 3CZOA 2O7FA 4BABA 3NZ4A 4BAAA 2X75A 1YFEA 1K7WA 3RD8A 3GZHA 4APAA 1HY0A 3R6QA 2PTQA 3C8TA 4ADLA 3KDYA 1EB4A 3TV2A 1T6PA 1C3CA 4V2QA 2RJSA 4C5UA 1GK2A 1FUOA 5F91A 1HY1A 1GKMA 4C5SA 1B8FA 2OHYA 1Q5NA 1DOFA 1T6JA 3QBPA 5D6BA 2E9FA 4V2RA 1FUPA 3R6YA 1YISA 1I0AA 1XWOA 2HVGA 4MX2A 3KDZA 1JSWA 4APBA 2PFMA 1C3UA 4EEIA 2VD6A 1U15A 3NO9A 4FLCA 3OCEA 1K62A 4NLEA 4EFCA 2O78A 2PTSA 4C5RA 2RJRA 1W27A 2O7BA 2NYFA 1YFMA 4HGVA 2J91A 1GK3A 1TJUA 1AUWA 2PTRA 3E04A 3R6VA 1TJVA 2QVEA 1DCNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FUS A;  2O6Y A;  4NSL A;  1Y2M A;  1U16 A;  5EYT A;  3GTD A;  2O7D A;  3BHG A;  1FUQ A;  1TJW A;  1TJ7 A;  2QGA B;  5EYV A;  5HW2 A;  2NYN A;  4C6G A;  2YII A;  3RRP A;  1FUR A;  5F92 A;  1J3U A;  3OCF A;  4ADM A;  2O7E A;  1GKJ A;  1KQ7 A;  1RE5 A;  4CQ5 A;  4FFX A;  1VDK A;  3UNV A;  3CZO A;  2O7F A;  4BAB A;  3NZ4 A;  4BAA A;  2X75 A;  1YFE A;  1K7W A;  3RD8 A;  3GZH A;  4APA A;  1HY0 A;  3R6Q A;  2PTQ A;  3C8T A;  4ADL A;  3KDY A;  1EB4 A;  3TV2 A;  1T6P A;  1C3C A;  4V2Q A;  2RJS A;  4C5U A;  1GK2 A;  1FUO A;  5F91 A;  1HY1 A;  1GKM A;  4C5S A;  1B8F A;  2OHY A;  1Q5N A;  1DOF A;  1T6J A;  3QBP A;  5D6B A;  2E9F A;  4V2R A;  1FUP A;  3R6Y A;  1YIS A;  1I0A A;  1XWO A;  2HVG A;  4MX2 A;  3KDZ A;  1JSW A;  4APB A;  2PFM A;  1C3U A;  4EEI A;  2VD6 A;  1U15 A;  3NO9 A;  4FLC A;  3OCE A;  1K62 A;  4NLE A;  4EFC A;  2O78 A;  2PTS A;  4C5R A;  2RJR A;  1W27 A;  2O7B A;  2NYF A;  1YFM A;  4HGV A;  2J91 A;  1GK3 A;  1TJU A;  1AUW A;  2PTR A;  3E04 A;  3R6V A;  1TJV A;  2QVE A;  1DCN A; 
#chains in the Genus database with same CATH topology
 2FUS A;  2O6Y A;  1Z4J A;  4NSL A;  4MWO A;  1Y2M A;  1U16 A;  2JAU A;  5EYT A;  1U0L A;  3GTD A;  2O7D A;  3BHG A;  1FUQ A;  4NFL A;  1XMC A;  1TJW A;  4L57 A;  1TJ7 A;  2QGA B;  5EYV A;  3U19 A;  2D27 A;  5HW2 A;  1Q92 A;  1XL7 A;  2NYN A;  1XLY A;  4C6G A;  2YII A;  5M0J A;  3RRP A;  1FUR A;  5F92 A;  1XMD A;  1J3U A;  3OCF A;  4ADM A;  4E88 A;  3BWV A;  4YIH A;  2O7E A;  1GKJ A;  1KQ7 A;  1RE5 A;  1XL8 A;  3F4T A;  4FFX A;  4CQ5 A;  3U13 A;  1VDK A;  3UNV A;  3CZO A;  2O7F A;  4BAB A;  1Z4M A;  3NZ4 A;  4BAA A;  2X75 A;  1T9H A;  1YFE A;  1K7W A;  3RD8 A;  3GZH A;  4APA A;  1HY0 A;  3F4S A;  3R6Q A;  2PTQ A;  3C8T A;  4ADL A;  3KDY A;  1Z4Q A;  1EB4 A;  3TV2 A;  2D28 C;  1T6P A;  1C3C A;  4V2Q A;  2RJS A;  4IQJ M;  4C5U A;  1GK2 A;  1FUO A;  4A15 A;  5H8W A;  5F91 A;  1HY1 A;  1GKM A;  4C5S A;  2VSF A;  1B8F A;  2OHY A;  1Q5N A;  3CRV A;  1DOF A;  1T6J A;  5M0I A;  3F4R A;  1IW7 D;  2FEL A;  3QBP A;  5D6B A;  2E9F A;  4V2R A;  1FUP A;  3R6Y A;  2JAR A;  4MUM A;  1YIS A;  1I0A A;  1XWO A;  1Z4K A;  2HVG A;  4MX2 A;  3KDZ A;  2YV5 A;  4L6C A;  1Z4I A;  1JSW A;  4APB A;  2PFM A;  2I7D A;  1MH9 A;  4WNL A;  1C3U A;  4EEI A;  2VD6 A;  1U15 A;  3NO9 A;  1Z4L A;  4FLC A;  2JAW A;  3OCE A;  1K62 A;  4NLE A;  4EFC A;  2O78 A;  2PTS A;  1Z4P X;  3CRW 1;  2FEN A;  4C5R A;  2RJR A;  1W27 A;  2RCN A;  2O7B A;  2NYF A;  1YFM A;  4HGV A;  2J91 A;  1GK3 A;  1Q91 A;  4L6A A;  3CI0 K;  1TJU A;  1AUW A;  2PTR A;  3E04 A;  4YIK A;  3R6V A;  1TJV A;  2JAO A;  2QVE A;  2VL7 A;  1DCN A; 
#chains in the Genus database with same CATH homology
 2FUS A;  2O6Y A;  4NSL A;  1Y2M A;  1U16 A;  5EYT A;  3GTD A;  2O7D A;  3BHG A;  1FUQ A;  1TJW A;  1TJ7 A;  2QGA B;  5EYV A;  5HW2 A;  2NYN A;  4C6G A;  2YII A;  3RRP A;  1FUR A;  5F92 A;  1J3U A;  3OCF A;  4ADM A;  2O7E A;  1GKJ A;  1KQ7 A;  1RE5 A;  4CQ5 A;  4FFX A;  1VDK A;  3UNV A;  3CZO A;  2O7F A;  4BAB A;  3NZ4 A;  4BAA A;  2X75 A;  1YFE A;  1K7W A;  3RD8 A;  3GZH A;  4APA A;  1HY0 A;  3R6Q A;  2PTQ A;  3C8T A;  4ADL A;  3KDY A;  1EB4 A;  3TV2 A;  1T6P A;  1C3C A;  4V2Q A;  2RJS A;  4C5U A;  1GK2 A;  1FUO A;  5F91 A;  1HY1 A;  1GKM A;  4C5S A;  1B8F A;  2OHY A;  1Q5N A;  1DOF A;  1T6J A;  3QBP A;  5D6B A;  2E9F A;  4V2R A;  1FUP A;  3R6Y A;  1YIS A;  1I0A A;  1XWO A;  2HVG A;  4MX2 A;  3KDZ A;  1JSW A;  4APB A;  2PFM A;  1C3U A;  4EEI A;  2VD6 A;  1U15 A;  3NO9 A;  4FLC A;  3OCE A;  1K62 A;  4NLE A;  4EFC A;  2O78 A;  2PTS A;  4C5R A;  2RJR A;  1W27 A;  2O7B A;  2NYF A;  1YFM A;  4HGV A;  2J91 A;  1GK3 A;  1TJU A;  1AUW A;  2PTR A;  3E04 A;  3R6V A;  1TJV A;  2QVE A;  1DCN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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