4ADLA

Crystal structures of rv1098c in complex with malate
Total Genus 177
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
sequence length
459
structure length
459
Chain Sequence
NYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Lyase
molecule keywords FUMARATE HYDRATASE CLASS II
total genus 177
structure length 459
sequence length 459
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2011-12-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4adlA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4adlA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4adlA02
1YISA 1GK2A 2RJRA 2FUSA 5HW2A 2O7FA 4C5SA 4APAA 1YFMA 4EEIA 3CZOA 3R6YA 2E9FA 2PTRA 4HGVA 4NSLA 3C8TA 1TJVA 1K7WA 4APBA 1U15A 3E04A 3NO9A 1C3UA 2VD6A 1T6PA 2NYNA 1FUPA 1TJWA 1B8FA 2YIIA 1Q5NA 3TV2A 1HY1A 1TJ7A 3UNVA 1KQ7A 2QGAB 3GZHA 4MX2A 3RD8A 2HVGA 3OCFA 4ADMA 4C5UA 3R6QA 3QBPA 2O7EA 4V2QA 4BABA 4BAAA 1U16A 5EYVA 5F92A 1Y2MA 2PFMA 2PTSA 1DOFA 3R6VA 1EB4A 4CQ5A 3BHGA 3RRPA 1JSWA 2NYFA 1FUOA 1YFEA 4C6GA 2PTQA 4NLEA 1VDKA 2OHYA 2O6YA 5F91A 2O7BA 3KDYA 4FFXA 3GTDA 1AUWA 2X75A 1DCNA 2J91A 2QVEA 1GK3A 3KDZA 1J3UA 3OCEA 4FLCA 1C3CA 2O78A 1T6JA 1GKMA 3NZ4A 1W27A 1FURA 1FUQA 1I0AA 4V2RA 1RE5A 1TJUA 4C5RA 4ADLA 4EFCA 1GKJA 1K62A 2RJSA 1XWOA 2O7DA 1HY0A 5D6BA 5EYTA
chains in the Genus database with same CATH superfamily
1YISA 1GK2A 2RJRA 1Z4PX 2FUSA 5HW2A 2O7FA 4C5SA 1XL7A 3BWVA 4APAA 1YFMA 4EEIA 1MH9A 2RCNA 5M0IA 3CZOA 2FENA 2JAWA 3R6YA 2E9FA 2PTRA 4HGVA 4NSLA 3C8TA 1T9HA 1TJVA 1K7WA 4APBA 1U15A 3E04A 4A15A 2D28C 3NO9A 4MUMA 1C3UA 1U0LA 2VD6A 4WNLA 1T6PA 5H8WA 2NYNA 1FUPA 3F4RA 1TJWA 1B8FA 2YIIA 1Q5NA 3TV2A 1HY1A 1TJ7A 3UNVA 1KQ7A 2QGAB 3GZHA 4MX2A 3RD8A 2HVGA 3OCFA 4L6CA 4ADMA 4NFLA 4C5UA 3R6QA 2VL7A 3QBPA 2O7EA 4V2QA 4BABA 4BAAA 1U16A 3CI0K 5EYVA 5F92A 1Q92A 2PFMA 1Z4JA 2PTSA 1Y2MA 1XLYA 1DOFA 3R6VA 1EB4A 4CQ5A 3BHGA 3F4TA 3RRPA 2VSFA 1XMDA 2JARA 1JSWA 2NYFA 1FUOA 1YFEA 4YIKA 2D27A 4YIHA 4C6GA 2PTQA 1Z4IA 4NLEA 1VDKA 2OHYA 2O6YA 5F91A 2O7BA 4IQJM 3KDYA 4FFXA 2JAOA 3GTDA 1AUWA 2X75A 3F4SA 3U13A 1DCNA 1IW7D 2FELA 2J91A 2QVEA 1GK3A 1Z4LA 3KDZA 1J3UA 3OCEA 4MWOA 4FLCA 2YV5A 1Z4MA 1C3CA 2O78A 4L57A 1GKMA 1T6JA 3NZ4A 1XL8A 1Z4KA 1W27A 1FURA 1FUQA 1I0AA 4V2RA 2I7DA 1RE5A 3CRVA 1XMCA 1TJUA 4C5RA 4ADLA 4EFCA 1GKJA 1K62A 1Q91A 1Z4QA 2JAUA 2RJSA 3CRW1 4E88A 1XWOA 4L6AA 2O7DA 1HY0A 5D6BA 5M0JA 3U19A 5EYTA
chains in the Genus database with same CATH topology
1YISA 1GK2A 2RJRA 2FUSA 5HW2A 2O7FA 4C5SA 4APAA 1YFMA 4EEIA 3CZOA 3R6YA 2E9FA 2PTRA 4HGVA 4NSLA 3C8TA 1TJVA 1K7WA 4APBA 1U15A 3E04A 3NO9A 1C3UA 2VD6A 1T6PA 2NYNA 1FUPA 1TJWA 1B8FA 2YIIA 1Q5NA 3TV2A 1HY1A 1TJ7A 3UNVA 1KQ7A 2QGAB 3GZHA 4MX2A 3RD8A 2HVGA 3OCFA 4ADMA 4C5UA 3R6QA 3QBPA 2O7EA 4V2QA 4BABA 4BAAA 1U16A 5EYVA 5F92A 1Y2MA 2PFMA 2PTSA 1DOFA 3R6VA 1EB4A 4CQ5A 3BHGA 3RRPA 1JSWA 2NYFA 1FUOA 1YFEA 4C6GA 2PTQA 4NLEA 1VDKA 2OHYA 2O6YA 5F91A 2O7BA 3KDYA 4FFXA 3GTDA 1AUWA 2X75A 1DCNA 2J91A 2QVEA 1GK3A 3KDZA 1J3UA 3OCEA 4FLCA 1C3CA 2O78A 1T6JA 1GKMA 3NZ4A 1W27A 1FURA 1FUQA 1I0AA 4V2RA 1RE5A 1TJUA 4C5RA 4ADLA 4EFCA 1GKJA 1K62A 2RJSA 1XWOA 2O7DA 1HY0A 5D6BA 5EYTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YIS A;  1GK2 A;  2RJR A;  2FUS A;  5HW2 A;  2O7F A;  4C5S A;  4APA A;  1YFM A;  4EEI A;  3CZO A;  3R6Y A;  2E9F A;  2PTR A;  4HGV A;  4NSL A;  3C8T A;  1TJV A;  1K7W A;  4APB A;  1U15 A;  3E04 A;  3NO9 A;  1C3U A;  2VD6 A;  1T6P A;  2NYN A;  1FUP A;  1TJW A;  1B8F A;  2YII A;  1Q5N A;  3TV2 A;  1HY1 A;  1TJ7 A;  3UNV A;  1KQ7 A;  2QGA B;  3GZH A;  4MX2 A;  3RD8 A;  2HVG A;  3OCF A;  4ADM A;  4C5U A;  3R6Q A;  3QBP A;  2O7E A;  4V2Q A;  4BAB A;  4BAA A;  1U16 A;  5EYV A;  5F92 A;  1Y2M A;  2PFM A;  2PTS A;  1DOF A;  3R6V A;  1EB4 A;  4CQ5 A;  3BHG A;  3RRP A;  1JSW A;  2NYF A;  1FUO A;  1YFE A;  4C6G A;  2PTQ A;  4NLE A;  1VDK A;  2OHY A;  2O6Y A;  5F91 A;  2O7B A;  3KDY A;  4FFX A;  3GTD A;  1AUW A;  2X75 A;  1DCN A;  2J91 A;  2QVE A;  1GK3 A;  3KDZ A;  1J3U A;  3OCE A;  4FLC A;  1C3C A;  2O78 A;  1T6J A;  1GKM A;  3NZ4 A;  1W27 A;  1FUR A;  1FUQ A;  1I0A A;  4V2R A;  1RE5 A;  1TJU A;  4C5R A;  4ADL A;  4EFC A;  1GKJ A;  1K62 A;  2RJS A;  1XWO A;  2O7D A;  1HY0 A;  5D6B A;  5EYT A; 
#chains in the Genus database with same CATH topology
 1YIS A;  1GK2 A;  2RJR A;  1Z4P X;  2FUS A;  5HW2 A;  2O7F A;  4C5S A;  1XL7 A;  3BWV A;  4APA A;  1YFM A;  4EEI A;  1MH9 A;  2RCN A;  5M0I A;  3CZO A;  2FEN A;  2JAW A;  3R6Y A;  2E9F A;  2PTR A;  4HGV A;  4NSL A;  3C8T A;  1T9H A;  1TJV A;  1K7W A;  4APB A;  1U15 A;  3E04 A;  4A15 A;  2D28 C;  3NO9 A;  4MUM A;  1C3U A;  1U0L A;  2VD6 A;  4WNL A;  1T6P A;  5H8W A;  2NYN A;  1FUP A;  3F4R A;  1TJW A;  1B8F A;  2YII A;  1Q5N A;  3TV2 A;  1HY1 A;  1TJ7 A;  3UNV A;  1KQ7 A;  2QGA B;  3GZH A;  4MX2 A;  3RD8 A;  2HVG A;  3OCF A;  4L6C A;  4ADM A;  4NFL A;  4C5U A;  3R6Q A;  2VL7 A;  3QBP A;  2O7E A;  4V2Q A;  4BAB A;  4BAA A;  1U16 A;  3CI0 K;  5EYV A;  5F92 A;  1Q92 A;  2PFM A;  1Z4J A;  2PTS A;  1Y2M A;  1XLY A;  1DOF A;  3R6V A;  1EB4 A;  4CQ5 A;  3BHG A;  3F4T A;  3RRP A;  2VSF A;  1XMD A;  2JAR A;  1JSW A;  2NYF A;  1FUO A;  1YFE A;  4YIK A;  2D27 A;  4YIH A;  4C6G A;  2PTQ A;  1Z4I A;  4NLE A;  1VDK A;  2OHY A;  2O6Y A;  5F91 A;  2O7B A;  4IQJ M;  3KDY A;  4FFX A;  2JAO A;  3GTD A;  1AUW A;  2X75 A;  3F4S A;  3U13 A;  1DCN A;  1IW7 D;  2FEL A;  2J91 A;  2QVE A;  1GK3 A;  1Z4L A;  3KDZ A;  1J3U A;  3OCE A;  4MWO A;  4FLC A;  2YV5 A;  1Z4M A;  1C3C A;  2O78 A;  4L57 A;  1GKM A;  1T6J A;  3NZ4 A;  1XL8 A;  1Z4K A;  1W27 A;  1FUR A;  1FUQ A;  1I0A A;  4V2R A;  2I7D A;  1RE5 A;  3CRV A;  1XMC A;  1TJU A;  4C5R A;  4ADL A;  4EFC A;  1GKJ A;  1K62 A;  1Q91 A;  1Z4Q A;  2JAU A;  2RJS A;  3CRW 1;  4E88 A;  1XWO A;  4L6A A;  2O7D A;  1HY0 A;  5D6B A;  5M0J A;  3U19 A;  5EYT A; 
#chains in the Genus database with same CATH homology
 1YIS A;  1GK2 A;  2RJR A;  2FUS A;  5HW2 A;  2O7F A;  4C5S A;  4APA A;  1YFM A;  4EEI A;  3CZO A;  3R6Y A;  2E9F A;  2PTR A;  4HGV A;  4NSL A;  3C8T A;  1TJV A;  1K7W A;  4APB A;  1U15 A;  3E04 A;  3NO9 A;  1C3U A;  2VD6 A;  1T6P A;  2NYN A;  1FUP A;  1TJW A;  1B8F A;  2YII A;  1Q5N A;  3TV2 A;  1HY1 A;  1TJ7 A;  3UNV A;  1KQ7 A;  2QGA B;  3GZH A;  4MX2 A;  3RD8 A;  2HVG A;  3OCF A;  4ADM A;  4C5U A;  3R6Q A;  3QBP A;  2O7E A;  4V2Q A;  4BAB A;  4BAA A;  1U16 A;  5EYV A;  5F92 A;  1Y2M A;  2PFM A;  2PTS A;  1DOF A;  3R6V A;  1EB4 A;  4CQ5 A;  3BHG A;  3RRP A;  1JSW A;  2NYF A;  1FUO A;  1YFE A;  4C6G A;  2PTQ A;  4NLE A;  1VDK A;  2OHY A;  2O6Y A;  5F91 A;  2O7B A;  3KDY A;  4FFX A;  3GTD A;  1AUW A;  2X75 A;  1DCN A;  2J91 A;  2QVE A;  1GK3 A;  3KDZ A;  1J3U A;  3OCE A;  4FLC A;  1C3C A;  2O78 A;  1T6J A;  1GKM A;  3NZ4 A;  1W27 A;  1FUR A;  1FUQ A;  1I0A A;  4V2R A;  1RE5 A;  1TJU A;  4C5R A;  4ADL A;  4EFC A;  1GKJ A;  1K62 A;  2RJS A;  1XWO A;  2O7D A;  1HY0 A;  5D6B A;  5EYT A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...