4ADLA

Crystal structures of rv1098c in complex with malate
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
sequence length
459
structure length
459
Chain Sequence
NYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lyase
molecule keywords FUMARATE HYDRATASE CLASS II
publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
total genus 177
structure length 459
sequence length 459
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2011-12-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4adlA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4adlA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4adlA02
2RJRA 1FUPA 1Q5NA 2NYNA 1U16A 3RRPA 1GK3A 4MX2A 5HW2A 2O78A 1I0AA 1TJ7A 3QBPA 1TJWA 2NYFA 4FFXA 2O7BA 3BHGA 3GZHA 2FUSA 2VD6A 3KDZA 5D6BA 2YIIA 4C5RA 3E04A 1HY1A 4V2QA 1TJUA 1FUQA 4C5SA 3R6QA 2QVEA 2PTSA 1Y2MA 3UNVA 4APAA 1TJVA 4BABA 1J3UA 4ADMA 3C8TA 1GKJA 2J91A 3NO9A 1HY0A 1AUWA 1YFMA 1FURA 2O7FA 1DCNA 1C3UA 2PTQA 1KQ7A 4C6GA 1K62A 1VDKA 2QGAB 2O7EA 1JSWA 1T6JA 2HVGA 4ADLA 1K7WA 4BAAA 5F91A 3TV2A 3RD8A 2X75A 3R6YA 4CQ5A 2PFMA 3OCFA 1U15A 5F92A 3GTDA 4V2RA 4FLCA 2RJSA 5EYVA 1RE5A 1T6PA 3R6VA 3NZ4A 1YISA 1GKMA 1DOFA 1XWOA 1W27A 3KDYA 1YFEA 2OHYA 3CZOA 1B8FA 1C3CA 1GK2A 4EEIA 4NLEA 3OCEA 2PTRA 2E9FA 4C5UA 4APBA 1FUOA 4EFCA 4NSLA 5EYTA 1EB4A 2O6YA 2O7DA 4HGVA
chains in the Genus database with same CATH superfamily
2I7DA 4WNLA 4MWOA 1FUPA 1Q5NA 1Z4LA 2NYNA 2JARA 1U16A 2RJRA 3RRPA 1GK3A 1IW7D 4MX2A 5HW2A 1XLYA 2O78A 1I0AA 1TJ7A 3QBPA 1TJWA 2NYFA 4L6AA 4FFXA 2O7BA 3BHGA 3GZHA 2FELA 3F4TA 2FUSA 3F4SA 1Z4KA 2VD6A 3KDZA 5D6BA 5M0IA 2YIIA 2VL7A 4C5RA 3E04A 1HY1A 4V2QA 1TJUA 1FUQA 4L57A 3R6QA 4C5SA 1XL8A 2QVEA 3CRVA 4NFLA 2PTSA 1Y2MA 3UNVA 4APAA 1TJVA 4BABA 1J3UA 2FENA 4E88A 2D27A 4A15A 4ADMA 3C8TA 1GKJA 2J91A 1T9HA 1Q92A 3NO9A 1HY0A 1AUWA 1YFMA 1FURA 2O7FA 1DCNA 1C3UA 2PTQA 4IQJM 3CRW1 1KQ7A 3U13A 4C6GA 1K62A 1VDKA 2QGAB 3U19A 2O7EA 1MH9A 1JSWA 1T6JA 2HVGA 4ADLA 1K7WA 1Z4MA 4BAAA 5F91A 1XMCA 2JAOA 3TV2A 3RD8A 2X75A 2YV5A 3R6YA 4CQ5A 4YIHA 1XMDA 2JAUA 2RCNA 1Z4QA 2PFMA 3F4RA 3OCFA 1U15A 5F92A 1Q91A 3GTDA 3CI0K 4V2RA 4FLCA 2RJSA 5EYVA 1RE5A 1T6PA 3R6VA 3NZ4A 1GKMA 1YISA 1DOFA 1XWOA 1W27A 3KDYA 1Z4IA 1YFEA 2D28C 1XL7A 2OHYA 3CZOA 1B8FA 1C3CA 1GK2A 2VSFA 4MUMA 4EEIA 4NLEA 3OCEA 2PTRA 2E9FA 4C5UA 4APBA 1FUOA 4EFCA 4L6CA 3BWVA 1Z4JA 4YIKA 5H8WA 2JAWA 4NSLA 5EYTA 1Z4PX 1EB4A 2O6YA 5M0JA 1U0LA 2O7DA 4HGVA
chains in the Genus database with same CATH topology
2RJRA 1FUPA 1Q5NA 2NYNA 1U16A 3RRPA 1GK3A 4MX2A 5HW2A 2O78A 1I0AA 1TJ7A 3QBPA 1TJWA 2NYFA 4FFXA 2O7BA 3BHGA 3GZHA 2FUSA 2VD6A 3KDZA 5D6BA 2YIIA 4C5RA 3E04A 1HY1A 4V2QA 1TJUA 1FUQA 4C5SA 3R6QA 2QVEA 2PTSA 1Y2MA 3UNVA 4APAA 1TJVA 4BABA 1J3UA 4ADMA 3C8TA 1GKJA 2J91A 3NO9A 1HY0A 1AUWA 1YFMA 1FURA 2O7FA 1DCNA 1C3UA 2PTQA 1KQ7A 4C6GA 1K62A 1VDKA 2QGAB 2O7EA 1JSWA 1T6JA 2HVGA 4ADLA 1K7WA 4BAAA 5F91A 3TV2A 3RD8A 2X75A 3R6YA 4CQ5A 2PFMA 3OCFA 1U15A 5F92A 3GTDA 4V2RA 4FLCA 2RJSA 5EYVA 1RE5A 1T6PA 3R6VA 3NZ4A 1YISA 1GKMA 1DOFA 1XWOA 1W27A 3KDYA 1YFEA 2OHYA 3CZOA 1B8FA 1C3CA 1GK2A 4EEIA 4NLEA 3OCEA 2PTRA 2E9FA 4C5UA 4APBA 1FUOA 4EFCA 4NSLA 5EYTA 1EB4A 2O6YA 2O7DA 4HGVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2RJR A;  1FUP A;  1Q5N A;  2NYN A;  1U16 A;  3RRP A;  1GK3 A;  4MX2 A;  5HW2 A;  2O78 A;  1I0A A;  1TJ7 A;  3QBP A;  1TJW A;  2NYF A;  4FFX A;  2O7B A;  3BHG A;  3GZH A;  2FUS A;  2VD6 A;  3KDZ A;  5D6B A;  2YII A;  4C5R A;  3E04 A;  1HY1 A;  4V2Q A;  1TJU A;  1FUQ A;  4C5S A;  3R6Q A;  2QVE A;  2PTS A;  1Y2M A;  3UNV A;  4APA A;  1TJV A;  4BAB A;  1J3U A;  4ADM A;  3C8T A;  1GKJ A;  2J91 A;  3NO9 A;  1HY0 A;  1AUW A;  1YFM A;  1FUR A;  2O7F A;  1DCN A;  1C3U A;  2PTQ A;  1KQ7 A;  4C6G A;  1K62 A;  1VDK A;  2QGA B;  2O7E A;  1JSW A;  1T6J A;  2HVG A;  4ADL A;  1K7W A;  4BAA A;  5F91 A;  3TV2 A;  3RD8 A;  2X75 A;  3R6Y A;  4CQ5 A;  2PFM A;  3OCF A;  1U15 A;  5F92 A;  3GTD A;  4V2R A;  4FLC A;  2RJS A;  5EYV A;  1RE5 A;  1T6P A;  3R6V A;  3NZ4 A;  1YIS A;  1GKM A;  1DOF A;  1XWO A;  1W27 A;  3KDY A;  1YFE A;  2OHY A;  3CZO A;  1B8F A;  1C3C A;  1GK2 A;  4EEI A;  4NLE A;  3OCE A;  2PTR A;  2E9F A;  4C5U A;  4APB A;  1FUO A;  4EFC A;  4NSL A;  5EYT A;  1EB4 A;  2O6Y A;  2O7D A;  4HGV A; 
#chains in the Genus database with same CATH topology
 2I7D A;  4WNL A;  4MWO A;  1FUP A;  1Q5N A;  1Z4L A;  2NYN A;  2JAR A;  1U16 A;  2RJR A;  3RRP A;  1GK3 A;  1IW7 D;  4MX2 A;  5HW2 A;  1XLY A;  2O78 A;  1I0A A;  1TJ7 A;  3QBP A;  1TJW A;  2NYF A;  4L6A A;  4FFX A;  2O7B A;  3BHG A;  3GZH A;  2FEL A;  3F4T A;  2FUS A;  3F4S A;  1Z4K A;  2VD6 A;  3KDZ A;  5D6B A;  5M0I A;  2YII A;  2VL7 A;  4C5R A;  3E04 A;  1HY1 A;  4V2Q A;  1TJU A;  1FUQ A;  4L57 A;  3R6Q A;  4C5S A;  1XL8 A;  2QVE A;  3CRV A;  4NFL A;  2PTS A;  1Y2M A;  3UNV A;  4APA A;  1TJV A;  4BAB A;  1J3U A;  2FEN A;  4E88 A;  2D27 A;  4A15 A;  4ADM A;  3C8T A;  1GKJ A;  2J91 A;  1T9H A;  1Q92 A;  3NO9 A;  1HY0 A;  1AUW A;  1YFM A;  1FUR A;  2O7F A;  1DCN A;  1C3U A;  2PTQ A;  4IQJ M;  3CRW 1;  1KQ7 A;  3U13 A;  4C6G A;  1K62 A;  1VDK A;  2QGA B;  3U19 A;  2O7E A;  1MH9 A;  1JSW A;  1T6J A;  2HVG A;  4ADL A;  1K7W A;  1Z4M A;  4BAA A;  5F91 A;  1XMC A;  2JAO A;  3TV2 A;  3RD8 A;  2X75 A;  2YV5 A;  3R6Y A;  4CQ5 A;  4YIH A;  1XMD A;  2JAU A;  2RCN A;  1Z4Q A;  2PFM A;  3F4R A;  3OCF A;  1U15 A;  5F92 A;  1Q91 A;  3GTD A;  3CI0 K;  4V2R A;  4FLC A;  2RJS A;  5EYV A;  1RE5 A;  1T6P A;  3R6V A;  3NZ4 A;  1GKM A;  1YIS A;  1DOF A;  1XWO A;  1W27 A;  3KDY A;  1Z4I A;  1YFE A;  2D28 C;  1XL7 A;  2OHY A;  3CZO A;  1B8F A;  1C3C A;  1GK2 A;  2VSF A;  4MUM A;  4EEI A;  4NLE A;  3OCE A;  2PTR A;  2E9F A;  4C5U A;  4APB A;  1FUO A;  4EFC A;  4L6C A;  3BWV A;  1Z4J A;  4YIK A;  5H8W A;  2JAW A;  4NSL A;  5EYT A;  1Z4P X;  1EB4 A;  2O6Y A;  5M0J A;  1U0L A;  2O7D A;  4HGV A; 
#chains in the Genus database with same CATH homology
 2RJR A;  1FUP A;  1Q5N A;  2NYN A;  1U16 A;  3RRP A;  1GK3 A;  4MX2 A;  5HW2 A;  2O78 A;  1I0A A;  1TJ7 A;  3QBP A;  1TJW A;  2NYF A;  4FFX A;  2O7B A;  3BHG A;  3GZH A;  2FUS A;  2VD6 A;  3KDZ A;  5D6B A;  2YII A;  4C5R A;  3E04 A;  1HY1 A;  4V2Q A;  1TJU A;  1FUQ A;  4C5S A;  3R6Q A;  2QVE A;  2PTS A;  1Y2M A;  3UNV A;  4APA A;  1TJV A;  4BAB A;  1J3U A;  4ADM A;  3C8T A;  1GKJ A;  2J91 A;  3NO9 A;  1HY0 A;  1AUW A;  1YFM A;  1FUR A;  2O7F A;  1DCN A;  1C3U A;  2PTQ A;  1KQ7 A;  4C6G A;  1K62 A;  1VDK A;  2QGA B;  2O7E A;  1JSW A;  1T6J A;  2HVG A;  4ADL A;  1K7W A;  4BAA A;  5F91 A;  3TV2 A;  3RD8 A;  2X75 A;  3R6Y A;  4CQ5 A;  2PFM A;  3OCF A;  1U15 A;  5F92 A;  3GTD A;  4V2R A;  4FLC A;  2RJS A;  5EYV A;  1RE5 A;  1T6P A;  3R6V A;  3NZ4 A;  1YIS A;  1GKM A;  1DOF A;  1XWO A;  1W27 A;  3KDY A;  1YFE A;  2OHY A;  3CZO A;  1B8F A;  1C3C A;  1GK2 A;  4EEI A;  4NLE A;  3OCE A;  2PTR A;  2E9F A;  4C5U A;  4APB A;  1FUO A;  4EFC A;  4NSL A;  5EYT A;  1EB4 A;  2O6Y A;  2O7D A;  4HGV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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