4ADLA

Crystal structures of rv1098c in complex with malate
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
sequence length
459
structure length
459
Chain Sequence
NYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords FUMARATE HYDRATASE CLASS II
publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Lyase
total genus 177
structure length 459
sequence length 459
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2011-12-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4adlA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4adlA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4adlA02
1T6JA 4NLEA 1HY1A 2PTSA 1GKJA 2PTRA 1FUPA 2QVEA 1U15A 1AUWA 3GTDA 2FUSA 1K7WA 1VDKA 5F91A 2J91A 2VD6A 4C5RA 5D6BA 1RE5A 3R6VA 4HGVA 3OCEA 3UNVA 3RRPA 4V2RA 4C5UA 1HY0A 1T6PA 4C5SA 5F92A 1J3UA 2E9FA 3C8TA 1DCNA 1XWOA 2O7FA 5EYVA 1B8FA 1Y2MA 1GK2A 2X75A 4EFCA 1TJVA 2O7BA 3KDZA 1JSWA 4C6GA 2RJSA 2OHYA 1U16A 2PFMA 1KQ7A 3OCFA 3NO9A 2O78A 2O7DA 1I0AA 2RJRA 2NYNA 1GKMA 4EEIA 1FUOA 1C3UA 1C3CA 5EYTA 4FLCA 1TJ7A 1YISA 3BHGA 2PTQA 3QBPA 4CQ5A 2NYFA 3GZHA 4NSLA 2O6YA 1Q5NA 2YIIA 4V2QA 3TV2A 5HW2A 1GK3A 1DOFA 1K62A 1FURA 1EB4A 4APBA 1YFMA 1TJUA 2QGAB 4MX2A 3R6YA 2HVGA 1W27A 4APAA 1YFEA 4ADLA 4BABA 3RD8A 1TJWA 3NZ4A 3CZOA 1FUQA 4FFXA 3KDYA 4ADMA 3R6QA 3E04A 2O7EA 4BAAA
chains in the Genus database with same CATH superfamily
3F4RA 1T6JA 1T9HA 4NLEA 1HY1A 2PTSA 1GKJA 2PTRA 1FUPA 2QVEA 1U15A 1AUWA 3GTDA 3CRVA 2FUSA 2VL7A 1K7WA 1VDKA 1Z4PX 5F91A 2JAUA 2J91A 2VD6A 1XMDA 4C5RA 5D6BA 1RE5A 3R6VA 4HGVA 3OCEA 3UNVA 3RRPA 4V2RA 4C5UA 1HY0A 2D28C 1T6PA 4C5SA 5F92A 1J3UA 2E9FA 3C8TA 1DCNA 1XWOA 2O7FA 5EYVA 1B8FA 1Y2MA 1Z4QA 1GK2A 1Z4MA 2RCNA 2X75A 4EFCA 1TJVA 3F4SA 1Q92A 4YIHA 2O7BA 3KDZA 1XLYA 1JSWA 4C6GA 2RJSA 3U13A 2OHYA 2FELA 1XL7A 1U16A 2PFMA 1XMCA 2FENA 3F4TA 1KQ7A 2VSFA 3OCFA 3NO9A 1Z4IA 2O78A 2O7DA 2JAOA 1IW7D 1I0AA 2RJRA 2NYNA 1GKMA 4EEIA 4IQJM 4L6AA 1FUOA 3CRW1 1C3UA 1C3CA 2D27A 5EYTA 4FLCA 1TJ7A 3BWVA 2JARA 3BHGA 1YISA 5H8WA 2PTQA 1Z4KA 1XL8A 3QBPA 3U19A 4CQ5A 2NYFA 3GZHA 4NFLA 4NSLA 4A15A 2O6YA 5M0JA 1Q5NA 2YIIA 4V2QA 3TV2A 5HW2A 1GK3A 1DOFA 3CI0K 1K62A 4L57A 1FURA 1EB4A 4L6CA 4APBA 1YFMA 1TJUA 2QGAB 4MX2A 4YIKA 3R6YA 4WNLA 4E88A 4MWOA 2HVGA 1W27A 2JAWA 4APAA 2YV5A 1YFEA 4ADLA 4BABA 2I7DA 4MUMA 1TJWA 3RD8A 1Z4LA 3NZ4A 3CZOA 1MH9A 1FUQA 4FFXA 3KDYA 4ADMA 1Q91A 3R6QA 3E04A 1U0LA 2O7EA 4BAAA 5M0IA 1Z4JA
chains in the Genus database with same CATH topology
1T6JA 4NLEA 1HY1A 2PTSA 1GKJA 2PTRA 1FUPA 2QVEA 1U15A 1AUWA 3GTDA 2FUSA 1K7WA 1VDKA 5F91A 2J91A 2VD6A 4C5RA 5D6BA 1RE5A 3R6VA 4HGVA 3OCEA 3UNVA 3RRPA 4V2RA 4C5UA 1HY0A 1T6PA 4C5SA 5F92A 1J3UA 2E9FA 3C8TA 1DCNA 1XWOA 2O7FA 5EYVA 1B8FA 1Y2MA 1GK2A 2X75A 4EFCA 1TJVA 2O7BA 3KDZA 1JSWA 4C6GA 2RJSA 2OHYA 1U16A 2PFMA 1KQ7A 3OCFA 3NO9A 2O78A 2O7DA 1I0AA 2RJRA 2NYNA 1GKMA 4EEIA 1FUOA 1C3UA 1C3CA 5EYTA 4FLCA 1TJ7A 1YISA 3BHGA 2PTQA 3QBPA 4CQ5A 2NYFA 3GZHA 4NSLA 2O6YA 1Q5NA 2YIIA 4V2QA 3TV2A 5HW2A 1GK3A 1DOFA 1K62A 1FURA 1EB4A 4APBA 1YFMA 1TJUA 2QGAB 4MX2A 3R6YA 2HVGA 1W27A 4APAA 1YFEA 4ADLA 4BABA 3RD8A 1TJWA 3NZ4A 3CZOA 1FUQA 4FFXA 3KDYA 4ADMA 3R6QA 3E04A 2O7EA 4BAAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1T6J A;  4NLE A;  1HY1 A;  2PTS A;  1GKJ A;  2PTR A;  1FUP A;  2QVE A;  1U15 A;  1AUW A;  3GTD A;  2FUS A;  1K7W A;  1VDK A;  5F91 A;  2J91 A;  2VD6 A;  4C5R A;  5D6B A;  1RE5 A;  3R6V A;  4HGV A;  3OCE A;  3UNV A;  3RRP A;  4V2R A;  4C5U A;  1HY0 A;  1T6P A;  4C5S A;  5F92 A;  1J3U A;  2E9F A;  3C8T A;  1DCN A;  1XWO A;  2O7F A;  5EYV A;  1B8F A;  1Y2M A;  1GK2 A;  2X75 A;  4EFC A;  1TJV A;  2O7B A;  3KDZ A;  1JSW A;  4C6G A;  2RJS A;  2OHY A;  1U16 A;  2PFM A;  1KQ7 A;  3OCF A;  3NO9 A;  2O78 A;  2O7D A;  1I0A A;  2RJR A;  2NYN A;  1GKM A;  4EEI A;  1FUO A;  1C3U A;  1C3C A;  5EYT A;  4FLC A;  1TJ7 A;  1YIS A;  3BHG A;  2PTQ A;  3QBP A;  4CQ5 A;  2NYF A;  3GZH A;  4NSL A;  2O6Y A;  1Q5N A;  2YII A;  4V2Q A;  3TV2 A;  5HW2 A;  1GK3 A;  1DOF A;  1K62 A;  1FUR A;  1EB4 A;  4APB A;  1YFM A;  1TJU A;  2QGA B;  4MX2 A;  3R6Y A;  2HVG A;  1W27 A;  4APA A;  1YFE A;  4ADL A;  4BAB A;  3RD8 A;  1TJW A;  3NZ4 A;  3CZO A;  1FUQ A;  4FFX A;  3KDY A;  4ADM A;  3R6Q A;  3E04 A;  2O7E A;  4BAA A; 
#chains in the Genus database with same CATH topology
 3F4R A;  1T6J A;  1T9H A;  4NLE A;  1HY1 A;  2PTS A;  1GKJ A;  2PTR A;  1FUP A;  2QVE A;  1U15 A;  1AUW A;  3GTD A;  3CRV A;  2FUS A;  2VL7 A;  1K7W A;  1VDK A;  1Z4P X;  5F91 A;  2JAU A;  2J91 A;  2VD6 A;  1XMD A;  4C5R A;  5D6B A;  1RE5 A;  3R6V A;  4HGV A;  3OCE A;  3UNV A;  3RRP A;  4V2R A;  4C5U A;  1HY0 A;  2D28 C;  1T6P A;  4C5S A;  5F92 A;  1J3U A;  2E9F A;  3C8T A;  1DCN A;  1XWO A;  2O7F A;  5EYV A;  1B8F A;  1Y2M A;  1Z4Q A;  1GK2 A;  1Z4M A;  2RCN A;  2X75 A;  4EFC A;  1TJV A;  3F4S A;  1Q92 A;  4YIH A;  2O7B A;  3KDZ A;  1XLY A;  1JSW A;  4C6G A;  2RJS A;  3U13 A;  2OHY A;  2FEL A;  1XL7 A;  1U16 A;  2PFM A;  1XMC A;  2FEN A;  3F4T A;  1KQ7 A;  2VSF A;  3OCF A;  3NO9 A;  1Z4I A;  2O78 A;  2O7D A;  2JAO A;  1IW7 D;  1I0A A;  2RJR A;  2NYN A;  1GKM A;  4EEI A;  4IQJ M;  4L6A A;  1FUO A;  3CRW 1;  1C3U A;  1C3C A;  2D27 A;  5EYT A;  4FLC A;  1TJ7 A;  3BWV A;  2JAR A;  3BHG A;  1YIS A;  5H8W A;  2PTQ A;  1Z4K A;  1XL8 A;  3QBP A;  3U19 A;  4CQ5 A;  2NYF A;  3GZH A;  4NFL A;  4NSL A;  4A15 A;  2O6Y A;  5M0J A;  1Q5N A;  2YII A;  4V2Q A;  3TV2 A;  5HW2 A;  1GK3 A;  1DOF A;  3CI0 K;  1K62 A;  4L57 A;  1FUR A;  1EB4 A;  4L6C A;  4APB A;  1YFM A;  1TJU A;  2QGA B;  4MX2 A;  4YIK A;  3R6Y A;  4WNL A;  4E88 A;  4MWO A;  2HVG A;  1W27 A;  2JAW A;  4APA A;  2YV5 A;  1YFE A;  4ADL A;  4BAB A;  2I7D A;  4MUM A;  1TJW A;  3RD8 A;  1Z4L A;  3NZ4 A;  3CZO A;  1MH9 A;  1FUQ A;  4FFX A;  3KDY A;  4ADM A;  1Q91 A;  3R6Q A;  3E04 A;  1U0L A;  2O7E A;  4BAA A;  5M0I A;  1Z4J A; 
#chains in the Genus database with same CATH homology
 1T6J A;  4NLE A;  1HY1 A;  2PTS A;  1GKJ A;  2PTR A;  1FUP A;  2QVE A;  1U15 A;  1AUW A;  3GTD A;  2FUS A;  1K7W A;  1VDK A;  5F91 A;  2J91 A;  2VD6 A;  4C5R A;  5D6B A;  1RE5 A;  3R6V A;  4HGV A;  3OCE A;  3UNV A;  3RRP A;  4V2R A;  4C5U A;  1HY0 A;  1T6P A;  4C5S A;  5F92 A;  1J3U A;  2E9F A;  3C8T A;  1DCN A;  1XWO A;  2O7F A;  5EYV A;  1B8F A;  1Y2M A;  1GK2 A;  2X75 A;  4EFC A;  1TJV A;  2O7B A;  3KDZ A;  1JSW A;  4C6G A;  2RJS A;  2OHY A;  1U16 A;  2PFM A;  1KQ7 A;  3OCF A;  3NO9 A;  2O78 A;  2O7D A;  1I0A A;  2RJR A;  2NYN A;  1GKM A;  4EEI A;  1FUO A;  1C3U A;  1C3C A;  5EYT A;  4FLC A;  1TJ7 A;  1YIS A;  3BHG A;  2PTQ A;  3QBP A;  4CQ5 A;  2NYF A;  3GZH A;  4NSL A;  2O6Y A;  1Q5N A;  2YII A;  4V2Q A;  3TV2 A;  5HW2 A;  1GK3 A;  1DOF A;  1K62 A;  1FUR A;  1EB4 A;  4APB A;  1YFM A;  1TJU A;  2QGA B;  4MX2 A;  3R6Y A;  2HVG A;  1W27 A;  4APA A;  1YFE A;  4ADL A;  4BAB A;  3RD8 A;  1TJW A;  3NZ4 A;  3CZO A;  1FUQ A;  4FFX A;  3KDY A;  4ADM A;  3R6Q A;  3E04 A;  2O7E A;  4BAA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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