3KDZA

X-ray crystal structure of a tyrosine aminomutase mutant construct with bound ligand
Total Genus 198
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
198
sequence length
527
structure length
526
Chain Sequence
VPVSVDGETLTVEAVRRVAEERATVDVPAESIAKAQKSREIFEGIAEQNIPIFGVTTGYGEMIYMQVDKSKEVELQTNLVRSHSAGVGPLFAEDEARAIVAARLNTLAKGHSAVRPIILERLAQYLNEGITPAIPEIGSLGDLAPLSHVASTLIGEGYVLRDGRPVETAQVLAERGIEPLELRFKEGLALINGTSGMTGLGSLVVGRALEQAQQAEIVTALLIEAVRGSTSPFLAEGHDIARPHEGQIDTAANMRALMRGSGLTVEHADLRRELQKDKEAGKDVQRSEIYLQKAYSLRAIPQVVGAVRDTLYHARHKLRIELNSANDNPLFFEGKEIFHGANFHGQPIAFAMDFVTIALTQLGVLAERQINRVLNRHLSYGLPEFLVSGDPGLHSGFAGAQYPATALVAENRTIGPASTQSVPSNGDNQDVVSMGLISARNARRVLSNNNKILAVEYLAAAQAVDISGRFDGLSPAAKATYEAVRRLVPTLGVDRYMADDIELVADALSRGEFLRAIARETDIQLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histidine ammonia-lyase
publication title Probing the active site of MIO-dependent aminomutases, key catalysts in the biosynthesis of beta-amino acids incorporated in secondary metabolites
pubmed doi rcsb
source organism Streptomyces globisporus
molecule tags Lyase
total genus 198
structure length 526
sequence length 527
chains with identical sequence B
ec nomenclature ec 4.3.1.23: Tyrosine ammonia-lyase.
pdb deposition date 2009-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3kdzA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3kdzA02
1FUQA 4APBA 4EEIA 1U16A 3UNVA 2O6YA 1TJVA 1TJ7A 4V2RA 1Y2MA 3GZHA 1T6PA 2O7DA 1B8FA 4ADLA 2X75A 2VD6A 2PFMA 1J3UA 4C5UA 2PTSA 2O78A 1YFMA 1W27A 3BHGA 5EYVA 1RE5A 4HGVA 1GKMA 2QVEA 4C5RA 2RJRA 3QBPA 4MX2A 1K7WA 4FFXA 3RD8A 4CQ5A 3OCEA 5HW2A 4APAA 2FUSA 1Q5NA 2PTRA 1EB4A 2YIIA 4ADMA 4BAAA 2PTQA 3KDYA 3NO9A 1YISA 1FUPA 1GK2A 4BABA 1GKJA 1C3UA 5EYTA 1TJWA 4NSLA 2OHYA 1AUWA 4EFCA 2NYFA 2O7BA 2E9FA 5F92A 1HY1A 2RJSA 2J91A 3RRPA 1VDKA 1GK3A 1DOFA 3NZ4A 1DCNA 1XWOA 3R6VA 1C3CA 1YFEA 1KQ7A 1JSWA 4V2QA 2QGAB 5F91A 4FLCA 4NLEA 1T6JA 3GTDA 2O7EA 3R6QA 1K62A 3R6YA 3E04A 3OCFA 4C6GA 1FUOA 1U15A 1TJUA 1HY0A 4C5SA 3TV2A 5D6BA 1FURA 3KDZA 2NYNA 3C8TA 2HVGA 3CZOA 2O7FA 1I0AA
chains in the Genus database with same CATH superfamily
1FUQA 4APBA 4EEIA 1U16A 3UNVA 2O6YA 1TJVA 1TJ7A 4V2RA 1Y2MA 3GZHA 1T6PA 2O7DA 1B8FA 4ADLA 2X75A 2VD6A 1XMDA 2PFMA 1XLYA 1J3UA 4C5UA 2PTSA 2O78A 1YFMA 1W27A 3BHGA 5EYVA 1RE5A 4HGVA 1GKMA 2QVEA 4C5RA 2RJRA 3QBPA 4MX2A 1K7WA 4FFXA 3RD8A 3CRW1 1XL7A 4CQ5A 3OCEA 5HW2A 4APAA 2FUSA 1Q5NA 2PTRA 1EB4A 2YIIA 4ADMA 4BAAA 2PTQA 3KDYA 3NO9A 1YISA 1FUPA 1GK2A 4BABA 1GKJA 1C3UA 5EYTA 1TJWA 4NSLA 2OHYA 4WNLA 1AUWA 4EFCA 2NYFA 2O7BA 2E9FA 5F92A 1HY1A 2RJSA 2J91A 3RRPA 3CRVA 1VDKA 1GK3A 1DOFA 3NZ4A 4A15A 1DCNA 1XWOA 3R6VA 2FENA 1XMCA 1C3CA 1YFEA 1KQ7A 1JSWA 4V2QA 2QGAB 5F91A 4FLCA 4NLEA 1T6JA 3GTDA 2O7EA 3R6QA 1K62A 3R6YA 3E04A 3OCFA 4C6GA 1FUOA 1U15A 1TJUA 1HY0A 4C5SA 3TV2A 5D6BA 1FURA 3KDZA 2NYNA 2VSFA 5M0JA 2VL7A 5H8WA 3C8TA 2HVGA 3CZOA 2O7FA 1I0AA 1XL8A 5M0IA 2FELA
chains in the Genus database with same CATH topology
1FUQA 4APBA 4EEIA 1U16A 3UNVA 2O6YA 1TJVA 1TJ7A 4V2RA 1Y2MA 3GZHA 1T6PA 2O7DA 1B8FA 4ADLA 2X75A 2VD6A 2PFMA 1J3UA 4C5UA 2PTSA 2O78A 1YFMA 1W27A 3BHGA 5EYVA 1RE5A 4HGVA 1GKMA 2QVEA 4C5RA 2RJRA 3QBPA 4MX2A 1K7WA 4FFXA 3RD8A 4CQ5A 3OCEA 5HW2A 4APAA 2FUSA 1Q5NA 2PTRA 1EB4A 2YIIA 4ADMA 4BAAA 2PTQA 3KDYA 3NO9A 1YISA 1FUPA 1GK2A 4BABA 1GKJA 1C3UA 5EYTA 1TJWA 4NSLA 2OHYA 1AUWA 4EFCA 2NYFA 2O7BA 2E9FA 5F92A 1HY1A 2RJSA 2J91A 3RRPA 1VDKA 1GK3A 1DOFA 3NZ4A 1DCNA 1XWOA 3R6VA 1C3CA 1YFEA 1KQ7A 1JSWA 4V2QA 2QGAB 5F91A 4FLCA 4NLEA 1T6JA 3GTDA 2O7EA 3R6QA 1K62A 3R6YA 3E04A 3OCFA 4C6GA 1FUOA 1U15A 1TJUA 1HY0A 4C5SA 3TV2A 5D6BA 1FURA 3KDZA 2NYNA 3C8TA 2HVGA 3CZOA 2O7FA 1I0AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FUQ A;  4APB A;  4EEI A;  1U16 A;  3UNV A;  2O6Y A;  1TJV A;  1TJ7 A;  4V2R A;  1Y2M A;  3GZH A;  1T6P A;  2O7D A;  1B8F A;  4ADL A;  2X75 A;  2VD6 A;  2PFM A;  1J3U A;  4C5U A;  2PTS A;  2O78 A;  1YFM A;  1W27 A;  3BHG A;  5EYV A;  1RE5 A;  4HGV A;  1GKM A;  2QVE A;  4C5R A;  2RJR A;  3QBP A;  4MX2 A;  1K7W A;  4FFX A;  3RD8 A;  4CQ5 A;  3OCE A;  5HW2 A;  4APA A;  2FUS A;  1Q5N A;  2PTR A;  1EB4 A;  2YII A;  4ADM A;  4BAA A;  2PTQ A;  3KDY A;  3NO9 A;  1YIS A;  1FUP A;  1GK2 A;  4BAB A;  1GKJ A;  1C3U A;  5EYT A;  1TJW A;  4NSL A;  2OHY A;  1AUW A;  4EFC A;  2NYF A;  2O7B A;  2E9F A;  5F92 A;  1HY1 A;  2RJS A;  2J91 A;  3RRP A;  1VDK A;  1GK3 A;  1DOF A;  3NZ4 A;  1DCN A;  1XWO A;  3R6V A;  1C3C A;  1YFE A;  1KQ7 A;  1JSW A;  4V2Q A;  2QGA B;  5F91 A;  4FLC A;  4NLE A;  1T6J A;  3GTD A;  2O7E A;  3R6Q A;  1K62 A;  3R6Y A;  3E04 A;  3OCF A;  4C6G A;  1FUO A;  1U15 A;  1TJU A;  1HY0 A;  4C5S A;  3TV2 A;  5D6B A;  1FUR A;  3KDZ A;  2NYN A;  3C8T A;  2HVG A;  3CZO A;  2O7F A;  1I0A A; 
#chains in the Genus database with same CATH topology
 1FUQ A;  4APB A;  4EEI A;  1U16 A;  3UNV A;  2O6Y A;  1TJV A;  1TJ7 A;  4V2R A;  1Y2M A;  3GZH A;  1T6P A;  2O7D A;  1B8F A;  4ADL A;  2X75 A;  2VD6 A;  1XMD A;  2PFM A;  1XLY A;  1J3U A;  4C5U A;  2PTS A;  2O78 A;  1YFM A;  1W27 A;  3BHG A;  5EYV A;  1RE5 A;  4HGV A;  1GKM A;  2QVE A;  4C5R A;  2RJR A;  3QBP A;  4MX2 A;  1K7W A;  4FFX A;  3RD8 A;  3CRW 1;  1XL7 A;  4CQ5 A;  3OCE A;  5HW2 A;  4APA A;  2FUS A;  1Q5N A;  2PTR A;  1EB4 A;  2YII A;  4ADM A;  4BAA A;  2PTQ A;  3KDY A;  3NO9 A;  1YIS A;  1FUP A;  1GK2 A;  4BAB A;  1GKJ A;  1C3U A;  5EYT A;  1TJW A;  4NSL A;  2OHY A;  4WNL A;  1AUW A;  4EFC A;  2NYF A;  2O7B A;  2E9F A;  5F92 A;  1HY1 A;  2RJS A;  2J91 A;  3RRP A;  3CRV A;  1VDK A;  1GK3 A;  1DOF A;  3NZ4 A;  4A15 A;  1DCN A;  1XWO A;  3R6V A;  2FEN A;  1XMC A;  1C3C A;  1YFE A;  1KQ7 A;  1JSW A;  4V2Q A;  2QGA B;  5F91 A;  4FLC A;  4NLE A;  1T6J A;  3GTD A;  2O7E A;  3R6Q A;  1K62 A;  3R6Y A;  3E04 A;  3OCF A;  4C6G A;  1FUO A;  1U15 A;  1TJU A;  1HY0 A;  4C5S A;  3TV2 A;  5D6B A;  1FUR A;  3KDZ A;  2NYN A;  2VSF A;  5M0J A;  2VL7 A;  5H8W A;  3C8T A;  2HVG A;  3CZO A;  2O7F A;  1I0A A;  1XL8 A;  5M0I A;  2FEL A; 
#chains in the Genus database with same CATH homology
 1FUQ A;  4APB A;  4EEI A;  1U16 A;  3UNV A;  2O6Y A;  1TJV A;  1TJ7 A;  4V2R A;  1Y2M A;  3GZH A;  1T6P A;  2O7D A;  1B8F A;  4ADL A;  2X75 A;  2VD6 A;  2PFM A;  1J3U A;  4C5U A;  2PTS A;  2O78 A;  1YFM A;  1W27 A;  3BHG A;  5EYV A;  1RE5 A;  4HGV A;  1GKM A;  2QVE A;  4C5R A;  2RJR A;  3QBP A;  4MX2 A;  1K7W A;  4FFX A;  3RD8 A;  4CQ5 A;  3OCE A;  5HW2 A;  4APA A;  2FUS A;  1Q5N A;  2PTR A;  1EB4 A;  2YII A;  4ADM A;  4BAA A;  2PTQ A;  3KDY A;  3NO9 A;  1YIS A;  1FUP A;  1GK2 A;  4BAB A;  1GKJ A;  1C3U A;  5EYT A;  1TJW A;  4NSL A;  2OHY A;  1AUW A;  4EFC A;  2NYF A;  2O7B A;  2E9F A;  5F92 A;  1HY1 A;  2RJS A;  2J91 A;  3RRP A;  1VDK A;  1GK3 A;  1DOF A;  3NZ4 A;  1DCN A;  1XWO A;  3R6V A;  1C3C A;  1YFE A;  1KQ7 A;  1JSW A;  4V2Q A;  2QGA B;  5F91 A;  4FLC A;  4NLE A;  1T6J A;  3GTD A;  2O7E A;  3R6Q A;  1K62 A;  3R6Y A;  3E04 A;  3OCF A;  4C6G A;  1FUO A;  1U15 A;  1TJU A;  1HY0 A;  4C5S A;  3TV2 A;  5D6B A;  1FUR A;  3KDZ A;  2NYN A;  3C8T A;  2HVG A;  3CZO A;  2O7F A;  1I0A A; 
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