3KDZA

X-ray crystal structure of a tyrosine aminomutase mutant construct with bound ligand
Total Genus 198
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
198
sequence length
527
structure length
526
Chain Sequence
VPVSVDGETLTVEAVRRVAEERATVDVPAESIAKAQKSREIFEGIAEQNIPIFGVTTGYGEMIYMQVDKSKEVELQTNLVRSHSAGVGPLFAEDEARAIVAARLNTLAKGHSAVRPIILERLAQYLNEGITPAIPEIGSLGDLAPLSHVASTLIGEGYVLRDGRPVETAQVLAERGIEPLELRFKEGLALINGTSGMTGLGSLVVGRALEQAQQAEIVTALLIEAVRGSTSPFLAEGHDIARPHEGQIDTAANMRALMRGSGLTVEHADLRRELQKDKEAGKDVQRSEIYLQKAYSLRAIPQVVGAVRDTLYHARHKLRIELNSANDNPLFFEGKEIFHGANFHGQPIAFAMDFVTIALTQLGVLAERQINRVLNRHLSYGLPEFLVSGDPGLHSGFAGAQYPATALVAENRTIGPASTQSVPSNGDNQDVVSMGLISARNARRVLSNNNKILAVEYLAAAQAVDISGRFDGLSPAAKATYEAVRRLVPTLGVDRYMADDIELVADALSRGEFLRAIARETDIQLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Lyase
molecule keywords Histidine ammonia-lyase
publication title Probing the active site of MIO-dependent aminomutases, key catalysts in the biosynthesis of beta-amino acids incorporated in secondary metabolites
pubmed doi rcsb
source organism Streptomyces globisporus
total genus 198
structure length 526
sequence length 527
chains with identical sequence B
ec nomenclature ec 4.3.1.23: Tyrosine ammonia-lyase.
pdb deposition date 2009-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3kdzA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3kdzA02
1C3UA 2O78A 3GTDA 1U16A 2O7EA 2O7DA 2E9FA 3QBPA 1GKJA 1K62A 1VDKA 5F92A 2YIIA 1I0AA 1FURA 1DOFA 1TJUA 2VD6A 4EFCA 1FUPA 4MX2A 2PFMA 4C6GA 3NO9A 4HGVA 1EB4A 2QGAB 4C5SA 1GKMA 5EYTA 3R6YA 5D6BA 1FUQA 2OHYA 1HY0A 2PTRA 4FLCA 4C5RA 3R6QA 3TV2A 2QVEA 1TJVA 4V2QA 2HVGA 1HY1A 2RJRA 4EEIA 2PTQA 1RE5A 4BAAA 2NYNA 2X75A 4APBA 3KDZA 1T6PA 3KDYA 1DCNA 4V2RA 3C8TA 1JSWA 4APAA 4NLEA 1T6JA 1C3CA 4BABA 3OCEA 4NSLA 3NZ4A 1Y2MA 1J3UA 2O7FA 1YFMA 1FUOA 4C5UA 2FUSA 5EYVA 5HW2A 1YISA 1TJWA 1Q5NA 1B8FA 3E04A 1GK2A 4ADMA 3RRPA 1TJ7A 4FFXA 4CQ5A 3R6VA 1U15A 2J91A 2NYFA 2O6YA 1GK3A 1XWOA 1K7WA 2PTSA 2O7BA 3UNVA 1AUWA 1W27A 3CZOA 2RJSA 1KQ7A 5F91A 3BHGA 3OCFA 3RD8A 3GZHA 1YFEA 4ADLA
chains in the Genus database with same CATH superfamily
1XMCA 1C3UA 2O78A 3GTDA 2VL7A 1U16A 2O7EA 2O7DA 2E9FA 1XL7A 3QBPA 1GKJA 1K62A 1VDKA 5F92A 2YIIA 1I0AA 1FURA 1DOFA 1TJUA 2VD6A 4EFCA 1FUPA 4MX2A 2PFMA 4C6GA 5M0JA 3NO9A 4HGVA 1EB4A 2QGAB 2VSFA 4C5SA 1GKMA 5EYTA 3R6YA 5D6BA 1FUQA 2OHYA 1HY0A 2PTRA 3CRW1 4FLCA 4C5RA 3R6QA 3TV2A 2QVEA 1TJVA 4V2QA 2HVGA 1XLYA 1HY1A 2RJRA 4EEIA 2PTQA 1RE5A 4BAAA 2NYNA 2X75A 4APBA 3KDZA 1XMDA 4WNLA 1T6PA 3KDYA 1DCNA 4A15A 4V2RA 1XL8A 3C8TA 1JSWA 4APAA 4NLEA 1T6JA 1C3CA 4BABA 3OCEA 4NSLA 3NZ4A 1Y2MA 1J3UA 2O7FA 1YFMA 1FUOA 4C5UA 2FUSA 5EYVA 5HW2A 1YISA 1TJWA 5M0IA 1Q5NA 1B8FA 3E04A 1GK2A 3CRVA 3RRPA 4ADMA 1TJ7A 2FENA 4FFXA 4CQ5A 2FELA 3R6VA 1U15A 2J91A 2NYFA 2O6YA 1GK3A 1XWOA 1K7WA 2PTSA 2O7BA 3UNVA 1AUWA 1W27A 3CZOA 2RJSA 1KQ7A 5F91A 3BHGA 3OCFA 3RD8A 3GZHA 5H8WA 1YFEA 4ADLA
chains in the Genus database with same CATH topology
1C3UA 2O78A 3GTDA 1U16A 2O7EA 2O7DA 2E9FA 3QBPA 1GKJA 1K62A 1VDKA 5F92A 2YIIA 1I0AA 1FURA 1DOFA 1TJUA 2VD6A 4EFCA 1FUPA 4MX2A 2PFMA 4C6GA 3NO9A 4HGVA 1EB4A 2QGAB 4C5SA 1GKMA 5EYTA 3R6YA 5D6BA 1FUQA 2OHYA 1HY0A 2PTRA 4FLCA 4C5RA 3R6QA 3TV2A 2QVEA 1TJVA 4V2QA 2HVGA 1HY1A 2RJRA 4EEIA 2PTQA 1RE5A 4BAAA 2NYNA 2X75A 4APBA 3KDZA 1T6PA 3KDYA 1DCNA 4V2RA 3C8TA 1JSWA 4APAA 4NLEA 1T6JA 1C3CA 4BABA 3OCEA 4NSLA 3NZ4A 1Y2MA 1J3UA 2O7FA 1YFMA 1FUOA 4C5UA 2FUSA 5EYVA 5HW2A 1YISA 1TJWA 1Q5NA 1B8FA 3E04A 1GK2A 4ADMA 3RRPA 1TJ7A 4FFXA 4CQ5A 3R6VA 1U15A 2J91A 2NYFA 2O6YA 1GK3A 1XWOA 1K7WA 2PTSA 2O7BA 3UNVA 1AUWA 1W27A 3CZOA 2RJSA 1KQ7A 5F91A 3BHGA 3OCFA 3RD8A 3GZHA 1YFEA 4ADLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C3U A;  2O78 A;  3GTD A;  1U16 A;  2O7E A;  2O7D A;  2E9F A;  3QBP A;  1GKJ A;  1K62 A;  1VDK A;  5F92 A;  2YII A;  1I0A A;  1FUR A;  1DOF A;  1TJU A;  2VD6 A;  4EFC A;  1FUP A;  4MX2 A;  2PFM A;  4C6G A;  3NO9 A;  4HGV A;  1EB4 A;  2QGA B;  4C5S A;  1GKM A;  5EYT A;  3R6Y A;  5D6B A;  1FUQ A;  2OHY A;  1HY0 A;  2PTR A;  4FLC A;  4C5R A;  3R6Q A;  3TV2 A;  2QVE A;  1TJV A;  4V2Q A;  2HVG A;  1HY1 A;  2RJR A;  4EEI A;  2PTQ A;  1RE5 A;  4BAA A;  2NYN A;  2X75 A;  4APB A;  3KDZ A;  1T6P A;  3KDY A;  1DCN A;  4V2R A;  3C8T A;  1JSW A;  4APA A;  4NLE A;  1T6J A;  1C3C A;  4BAB A;  3OCE A;  4NSL A;  3NZ4 A;  1Y2M A;  1J3U A;  2O7F A;  1YFM A;  1FUO A;  4C5U A;  2FUS A;  5EYV A;  5HW2 A;  1YIS A;  1TJW A;  1Q5N A;  1B8F A;  3E04 A;  1GK2 A;  4ADM A;  3RRP A;  1TJ7 A;  4FFX A;  4CQ5 A;  3R6V A;  1U15 A;  2J91 A;  2NYF A;  2O6Y A;  1GK3 A;  1XWO A;  1K7W A;  2PTS A;  2O7B A;  3UNV A;  1AUW A;  1W27 A;  3CZO A;  2RJS A;  1KQ7 A;  5F91 A;  3BHG A;  3OCF A;  3RD8 A;  3GZH A;  1YFE A;  4ADL A; 
#chains in the Genus database with same CATH topology
 1XMC A;  1C3U A;  2O78 A;  3GTD A;  2VL7 A;  1U16 A;  2O7E A;  2O7D A;  2E9F A;  1XL7 A;  3QBP A;  1GKJ A;  1K62 A;  1VDK A;  5F92 A;  2YII A;  1I0A A;  1FUR A;  1DOF A;  1TJU A;  2VD6 A;  4EFC A;  1FUP A;  4MX2 A;  2PFM A;  4C6G A;  5M0J A;  3NO9 A;  4HGV A;  1EB4 A;  2QGA B;  2VSF A;  4C5S A;  1GKM A;  5EYT A;  3R6Y A;  5D6B A;  1FUQ A;  2OHY A;  1HY0 A;  2PTR A;  3CRW 1;  4FLC A;  4C5R A;  3R6Q A;  3TV2 A;  2QVE A;  1TJV A;  4V2Q A;  2HVG A;  1XLY A;  1HY1 A;  2RJR A;  4EEI A;  2PTQ A;  1RE5 A;  4BAA A;  2NYN A;  2X75 A;  4APB A;  3KDZ A;  1XMD A;  4WNL A;  1T6P A;  3KDY A;  1DCN A;  4A15 A;  4V2R A;  1XL8 A;  3C8T A;  1JSW A;  4APA A;  4NLE A;  1T6J A;  1C3C A;  4BAB A;  3OCE A;  4NSL A;  3NZ4 A;  1Y2M A;  1J3U A;  2O7F A;  1YFM A;  1FUO A;  4C5U A;  2FUS A;  5EYV A;  5HW2 A;  1YIS A;  1TJW A;  5M0I A;  1Q5N A;  1B8F A;  3E04 A;  1GK2 A;  3CRV A;  3RRP A;  4ADM A;  1TJ7 A;  2FEN A;  4FFX A;  4CQ5 A;  2FEL A;  3R6V A;  1U15 A;  2J91 A;  2NYF A;  2O6Y A;  1GK3 A;  1XWO A;  1K7W A;  2PTS A;  2O7B A;  3UNV A;  1AUW A;  1W27 A;  3CZO A;  2RJS A;  1KQ7 A;  5F91 A;  3BHG A;  3OCF A;  3RD8 A;  3GZH A;  5H8W A;  1YFE A;  4ADL A; 
#chains in the Genus database with same CATH homology
 1C3U A;  2O78 A;  3GTD A;  1U16 A;  2O7E A;  2O7D A;  2E9F A;  3QBP A;  1GKJ A;  1K62 A;  1VDK A;  5F92 A;  2YII A;  1I0A A;  1FUR A;  1DOF A;  1TJU A;  2VD6 A;  4EFC A;  1FUP A;  4MX2 A;  2PFM A;  4C6G A;  3NO9 A;  4HGV A;  1EB4 A;  2QGA B;  4C5S A;  1GKM A;  5EYT A;  3R6Y A;  5D6B A;  1FUQ A;  2OHY A;  1HY0 A;  2PTR A;  4FLC A;  4C5R A;  3R6Q A;  3TV2 A;  2QVE A;  1TJV A;  4V2Q A;  2HVG A;  1HY1 A;  2RJR A;  4EEI A;  2PTQ A;  1RE5 A;  4BAA A;  2NYN A;  2X75 A;  4APB A;  3KDZ A;  1T6P A;  3KDY A;  1DCN A;  4V2R A;  3C8T A;  1JSW A;  4APA A;  4NLE A;  1T6J A;  1C3C A;  4BAB A;  3OCE A;  4NSL A;  3NZ4 A;  1Y2M A;  1J3U A;  2O7F A;  1YFM A;  1FUO A;  4C5U A;  2FUS A;  5EYV A;  5HW2 A;  1YIS A;  1TJW A;  1Q5N A;  1B8F A;  3E04 A;  1GK2 A;  4ADM A;  3RRP A;  1TJ7 A;  4FFX A;  4CQ5 A;  3R6V A;  1U15 A;  2J91 A;  2NYF A;  2O6Y A;  1GK3 A;  1XWO A;  1K7W A;  2PTS A;  2O7B A;  3UNV A;  1AUW A;  1W27 A;  3CZO A;  2RJS A;  1KQ7 A;  5F91 A;  3BHG A;  3OCF A;  3RD8 A;  3GZH A;  1YFE A;  4ADL A; 
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