4MX2A

Crystal structure of adenylosuccinate lyase from leishmania donovani
Total Genus 170
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
170
sequence length
453
structure length
424
Chain Sequence
EISQDSPLYSLSPLDGRYKRDTTPLRAYFSEYALFKYRVQVEVLYFEALCKEVPAITQLRGVTDAQLGELRATTFENFAVDDAKIIKGIEAVTNHDIKAVEYYLKDKMSACGLEAEKEFIHFGLTSQDINNTSIPMLLRDALHHHYIPTLDQLIALLKSKLPEWDVPMLARTHGQPASPTNLAKEFMVWIERLEEQRTMLLSIPNTGKFGGATGNFNAHLCAYPGVNWLDFGELFLSKYLGLRRQRYTTQIEHYDNLAAICDACARLHTILMDLAKDVWQYISLGYFDQKVREVGVNPIDFENAEGNLGMSNAVLGFLSAKLPISRLQRDLTDSTVLRNLGVPLSHALIAFASLRRGIDKLLLNKDVIASDLEGNWAVVAEGIQTVLRREGVTEETVHRFVQQITEEVRQELLAITPFTYVGYT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of adenylosuccinate lyase from Leishmania donovani
rcsb
source organism Leishmania donovani
molecule tags Lyase
molecule keywords Adenylosuccinate lyase
total genus 170
structure length 424
sequence length 453
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature
pdb deposition date 2013-09-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF08328 ASL_C Adenylosuccinate lyase C-terminal
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4mx2A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4mx2A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4mx2A02
1HY0A 4NSLA 4C6GA 4NLEA 4ADMA 1U16A 2O7DA 5EYVA 1TJVA 4MX2A 3QBPA 4V2QA 1VDKA 1C3UA 1B8FA 2PTQA 1RE5A 1Q5NA 1T6JA 3TV2A 2NYNA 1W27A 2O78A 1K7WA 1FURA 3NZ4A 4HGVA 2O7BA 2HVGA 3OCFA 2J91A 1JSWA 1TJUA 4V2RA 4BAAA 1XWOA 3BHGA 1DCNA 4C5UA 2NYFA 1J3UA 1TJ7A 3OCEA 4C5RA 3NO9A 1YFEA 2RJRA 3RD8A 4EEIA 1Y2MA 2YIIA 2OHYA 4EFCA 3R6QA 1GKMA 2VD6A 2PTRA 1AUWA 3UNVA 2O7EA 1YISA 1GK2A 4FLCA 1TJWA 2QGAB 2RJSA 4CQ5A 1K62A 4BABA 1DOFA 3R6YA 1GKJA 1U15A 3KDYA 3E04A 1YFMA 4C5SA 2QVEA 3KDZA 3GZHA 3C8TA 2O6YA 4FFXA 1KQ7A 5F91A 2FUSA 3R6VA 2O7FA 3RRPA 1EB4A 1FUOA 4APBA 3GTDA 1HY1A 5HW2A 3CZOA 2PFMA 4APAA 1I0AA 1T6PA 5EYTA 2X75A 5F92A 2E9FA 4ADLA 1GK3A 1FUQA 1C3CA 5D6BA 1FUPA 2PTSA
chains in the Genus database with same CATH superfamily
1HY0A 4NSLA 2VL7A 4C6GA 4NLEA 4ADMA 1U16A 1Z4KA 4L6CA 2JAWA 1IW7D 2O7DA 5EYVA 4MX2A 1TJVA 2YV5A 3QBPA 4V2QA 5M0IA 1VDKA 1C3UA 1B8FA 2PTQA 1RE5A 1Q5NA 1T6JA 3TV2A 2NYNA 1T9HA 1W27A 2O78A 1K7WA 1FURA 3NZ4A 4HGVA 2O7BA 2HVGA 4E88A 3OCFA 4WNLA 2JARA 2J91A 4NFLA 1JSWA 1TJUA 2VSFA 4V2RA 4BAAA 1XWOA 3BHGA 1XMCA 1DCNA 1MH9A 4C5UA 1Z4PX 3BWVA 3CRVA 2NYFA 1J3UA 1TJ7A 1U0LA 3OCEA 3U19A 2FENA 4C5RA 2D27A 3NO9A 1YFEA 3F4TA 2RJRA 3RD8A 3CRW1 4EEIA 1Y2MA 2YIIA 3CI0K 4YIKA 2JAOA 1XL8A 3R6QA 4EFCA 2OHYA 1XLYA 1GKMA 2VD6A 2PTRA 1AUWA 3UNVA 2O7EA 2FELA 1YISA 3F4SA 1GK2A 4FLCA 1TJWA 2QGAB 1Q92A 4YIHA 2RJSA 4CQ5A 1XMDA 1K62A 1XL7A 4BABA 1DOFA 5M0JA 1Z4IA 2D28C 3R6YA 1GKJA 1U15A 3KDYA 3E04A 3U13A 1YFMA 4L57A 4C5SA 2QVEA 3KDZA 3GZHA 3C8TA 3F4RA 2O6YA 4FFXA 1KQ7A 4MWOA 5F91A 2FUSA 1Z4JA 4MUMA 3R6VA 2O7FA 2RCNA 3RRPA 1EB4A 1Z4MA 1FUOA 4APBA 3GTDA 5H8WA 4L6AA 1Z4LA 1HY1A 5HW2A 2I7DA 3CZOA 1Z4QA 2PFMA 4A15A 4APAA 1I0AA 1T6PA 5EYTA 2X75A 5F92A 1Q91A 2E9FA 4ADLA 1GK3A 1FUQA 1C3CA 4IQJM 5D6BA 2JAUA 1FUPA 2PTSA
chains in the Genus database with same CATH topology
1HY0A 4NSLA 4C6GA 4NLEA 4ADMA 1U16A 2O7DA 5EYVA 1TJVA 4MX2A 3QBPA 4V2QA 1VDKA 1C3UA 1B8FA 2PTQA 1RE5A 1Q5NA 1T6JA 3TV2A 2NYNA 1W27A 2O78A 1K7WA 1FURA 3NZ4A 4HGVA 2O7BA 2HVGA 3OCFA 2J91A 1JSWA 1TJUA 4V2RA 4BAAA 1XWOA 3BHGA 1DCNA 4C5UA 2NYFA 1J3UA 1TJ7A 3OCEA 4C5RA 3NO9A 1YFEA 2RJRA 3RD8A 4EEIA 1Y2MA 2YIIA 2OHYA 4EFCA 3R6QA 1GKMA 2VD6A 2PTRA 1AUWA 3UNVA 2O7EA 1YISA 1GK2A 4FLCA 1TJWA 2QGAB 2RJSA 4CQ5A 1K62A 4BABA 1DOFA 3R6YA 1GKJA 1U15A 3KDYA 3E04A 1YFMA 4C5SA 2QVEA 3KDZA 3GZHA 3C8TA 2O6YA 4FFXA 1KQ7A 5F91A 2FUSA 3R6VA 2O7FA 3RRPA 1EB4A 1FUOA 4APBA 3GTDA 1HY1A 5HW2A 3CZOA 2PFMA 4APAA 1I0AA 1T6PA 5EYTA 2X75A 5F92A 2E9FA 4ADLA 1GK3A 1FUQA 1C3CA 5D6BA 1FUPA 2PTSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HY0 A;  4NSL A;  4C6G A;  4NLE A;  4ADM A;  1U16 A;  2O7D A;  5EYV A;  1TJV A;  4MX2 A;  3QBP A;  4V2Q A;  1VDK A;  1C3U A;  1B8F A;  2PTQ A;  1RE5 A;  1Q5N A;  1T6J A;  3TV2 A;  2NYN A;  1W27 A;  2O78 A;  1K7W A;  1FUR A;  3NZ4 A;  4HGV A;  2O7B A;  2HVG A;  3OCF A;  2J91 A;  1JSW A;  1TJU A;  4V2R A;  4BAA A;  1XWO A;  3BHG A;  1DCN A;  4C5U A;  2NYF A;  1J3U A;  1TJ7 A;  3OCE A;  4C5R A;  3NO9 A;  1YFE A;  2RJR A;  3RD8 A;  4EEI A;  1Y2M A;  2YII A;  2OHY A;  4EFC A;  3R6Q A;  1GKM A;  2VD6 A;  2PTR A;  1AUW A;  3UNV A;  2O7E A;  1YIS A;  1GK2 A;  4FLC A;  1TJW A;  2QGA B;  2RJS A;  4CQ5 A;  1K62 A;  4BAB A;  1DOF A;  3R6Y A;  1GKJ A;  1U15 A;  3KDY A;  3E04 A;  1YFM A;  4C5S A;  2QVE A;  3KDZ A;  3GZH A;  3C8T A;  2O6Y A;  4FFX A;  1KQ7 A;  5F91 A;  2FUS A;  3R6V A;  2O7F A;  3RRP A;  1EB4 A;  1FUO A;  4APB A;  3GTD A;  1HY1 A;  5HW2 A;  3CZO A;  2PFM A;  4APA A;  1I0A A;  1T6P A;  5EYT A;  2X75 A;  5F92 A;  2E9F A;  4ADL A;  1GK3 A;  1FUQ A;  1C3C A;  5D6B A;  1FUP A;  2PTS A; 
#chains in the Genus database with same CATH topology
 1HY0 A;  4NSL A;  2VL7 A;  4C6G A;  4NLE A;  4ADM A;  1U16 A;  1Z4K A;  4L6C A;  2JAW A;  1IW7 D;  2O7D A;  5EYV A;  4MX2 A;  1TJV A;  2YV5 A;  3QBP A;  4V2Q A;  5M0I A;  1VDK A;  1C3U A;  1B8F A;  2PTQ A;  1RE5 A;  1Q5N A;  1T6J A;  3TV2 A;  2NYN A;  1T9H A;  1W27 A;  2O78 A;  1K7W A;  1FUR A;  3NZ4 A;  4HGV A;  2O7B A;  2HVG A;  4E88 A;  3OCF A;  4WNL A;  2JAR A;  2J91 A;  4NFL A;  1JSW A;  1TJU A;  2VSF A;  4V2R A;  4BAA A;  1XWO A;  3BHG A;  1XMC A;  1DCN A;  1MH9 A;  4C5U A;  1Z4P X;  3BWV A;  3CRV A;  2NYF A;  1J3U A;  1TJ7 A;  1U0L A;  3OCE A;  3U19 A;  2FEN A;  4C5R A;  2D27 A;  3NO9 A;  1YFE A;  3F4T A;  2RJR A;  3RD8 A;  3CRW 1;  4EEI A;  1Y2M A;  2YII A;  3CI0 K;  4YIK A;  2JAO A;  1XL8 A;  3R6Q A;  4EFC A;  2OHY A;  1XLY A;  1GKM A;  2VD6 A;  2PTR A;  1AUW A;  3UNV A;  2O7E A;  2FEL A;  1YIS A;  3F4S A;  1GK2 A;  4FLC A;  1TJW A;  2QGA B;  1Q92 A;  4YIH A;  2RJS A;  4CQ5 A;  1XMD A;  1K62 A;  1XL7 A;  4BAB A;  1DOF A;  5M0J A;  1Z4I A;  2D28 C;  3R6Y A;  1GKJ A;  1U15 A;  3KDY A;  3E04 A;  3U13 A;  1YFM A;  4L57 A;  4C5S A;  2QVE A;  3KDZ A;  3GZH A;  3C8T A;  3F4R A;  2O6Y A;  4FFX A;  1KQ7 A;  4MWO A;  5F91 A;  2FUS A;  1Z4J A;  4MUM A;  3R6V A;  2O7F A;  2RCN A;  3RRP A;  1EB4 A;  1Z4M A;  1FUO A;  4APB A;  3GTD A;  5H8W A;  4L6A A;  1Z4L A;  1HY1 A;  5HW2 A;  2I7D A;  3CZO A;  1Z4Q A;  2PFM A;  4A15 A;  4APA A;  1I0A A;  1T6P A;  5EYT A;  2X75 A;  5F92 A;  1Q91 A;  2E9F A;  4ADL A;  1GK3 A;  1FUQ A;  1C3C A;  4IQJ M;  5D6B A;  2JAU A;  1FUP A;  2PTS A; 
#chains in the Genus database with same CATH homology
 1HY0 A;  4NSL A;  4C6G A;  4NLE A;  4ADM A;  1U16 A;  2O7D A;  5EYV A;  1TJV A;  4MX2 A;  3QBP A;  4V2Q A;  1VDK A;  1C3U A;  1B8F A;  2PTQ A;  1RE5 A;  1Q5N A;  1T6J A;  3TV2 A;  2NYN A;  1W27 A;  2O78 A;  1K7W A;  1FUR A;  3NZ4 A;  4HGV A;  2O7B A;  2HVG A;  3OCF A;  2J91 A;  1JSW A;  1TJU A;  4V2R A;  4BAA A;  1XWO A;  3BHG A;  1DCN A;  4C5U A;  2NYF A;  1J3U A;  1TJ7 A;  3OCE A;  4C5R A;  3NO9 A;  1YFE A;  2RJR A;  3RD8 A;  4EEI A;  1Y2M A;  2YII A;  2OHY A;  4EFC A;  3R6Q A;  1GKM A;  2VD6 A;  2PTR A;  1AUW A;  3UNV A;  2O7E A;  1YIS A;  1GK2 A;  4FLC A;  1TJW A;  2QGA B;  2RJS A;  4CQ5 A;  1K62 A;  4BAB A;  1DOF A;  3R6Y A;  1GKJ A;  1U15 A;  3KDY A;  3E04 A;  1YFM A;  4C5S A;  2QVE A;  3KDZ A;  3GZH A;  3C8T A;  2O6Y A;  4FFX A;  1KQ7 A;  5F91 A;  2FUS A;  3R6V A;  2O7F A;  3RRP A;  1EB4 A;  1FUO A;  4APB A;  3GTD A;  1HY1 A;  5HW2 A;  3CZO A;  2PFM A;  4APA A;  1I0A A;  1T6P A;  5EYT A;  2X75 A;  5F92 A;  2E9F A;  4ADL A;  1GK3 A;  1FUQ A;  1C3C A;  5D6B A;  1FUP A;  2PTS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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