4MX2A

Crystal structure of adenylosuccinate lyase from leishmania donovani
Total Genus 170
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
170
sequence length
453
structure length
424
Chain Sequence
EISQDSPLYSLSPLDGRYKRDTTPLRAYFSEYALFKYRVQVEVLYFEALCKEVPAITQLRGVTDAQLGELRATTFENFAVDDAKIIKGIEAVTNHDIKAVEYYLKDKMSACGLEAEKEFIHFGLTSQDINNTSIPMLLRDALHHHYIPTLDQLIALLKSKLPEWDVPMLARTHGQPASPTNLAKEFMVWIERLEEQRTMLLSIPNTGKFGGATGNFNAHLCAYPGVNWLDFGELFLSKYLGLRRQRYTTQIEHYDNLAAICDACARLHTILMDLAKDVWQYISLGYFDQKVREVGVNPIDFENAEGNLGMSNAVLGFLSAKLPISRLQRDLTDSTVLRNLGVPLSHALIAFASLRRGIDKLLLNKDVIASDLEGNWAVVAEGIQTVLRREGVTEETVHRFVQQITEEVRQELLAITPFTYVGYT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of adenylosuccinate lyase from Leishmania donovani
rcsb
source organism Leishmania donovani
molecule tags Lyase
molecule keywords Adenylosuccinate lyase
total genus 170
structure length 424
sequence length 453
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature
pdb deposition date 2013-09-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF08328 ASL_C Adenylosuccinate lyase C-terminal
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4mx2A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4mx2A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4mx2A02
1DOFA 2O78A 4HGVA 4EFCA 2NYFA 1JSWA 3R6VA 1TJWA 3CZOA 4NLEA 1FUQA 3RD8A 4APAA 3TV2A 2PTRA 4ADMA 1T6JA 1GKMA 1DCNA 1I0AA 1HY1A 1FUOA 2PTSA 5F92A 1TJ7A 4C5RA 2RJRA 1B8FA 1Y2MA 2O7FA 3OCEA 4V2RA 4MX2A 3KDZA 3RRPA 2X75A 4APBA 5EYVA 2O7DA 3GTDA 1C3UA 1FUPA 1VDKA 1K62A 4C5SA 3E04A 1YISA 1KQ7A 3BHGA 2J91A 1YFEA 3NZ4A 1U16A 1K7WA 5F91A 4FFXA 2PTQA 4FLCA 5D6BA 2PFMA 4ADLA 4BABA 1FURA 3R6YA 4V2QA 2NYNA 4C5UA 1T6PA 1J3UA 3OCFA 3C8TA 3QBPA 1HY0A 1U15A 1TJVA 1W27A 2O6YA 1XWOA 1GK2A 4C6GA 2RJSA 1YFMA 2VD6A 2OHYA 1RE5A 1AUWA 2E9FA 3UNVA 3R6QA 2O7BA 2YIIA 4BAAA 3GZHA 3KDYA 2QGAB 4CQ5A 4EEIA 2O7EA 3NO9A 1TJUA 2FUSA 5HW2A 1C3CA 5EYTA 2QVEA 2HVGA 1Q5NA 4NSLA 1GK3A 1GKJA 1EB4A
chains in the Genus database with same CATH superfamily
1DOFA 5H8WA 2O78A 4HGVA 4EFCA 2NYFA 1JSWA 3R6VA 1TJWA 3CZOA 1Z4JA 4NLEA 5M0JA 1FUQA 3RD8A 1Z4QA 4APAA 4NFLA 3TV2A 1XL7A 2PTRA 4ADMA 1T6JA 1GKMA 2VSFA 4E88A 1Z4LA 1DCNA 1I0AA 1HY1A 2D28C 3U13A 1FUOA 2PTSA 5F92A 1TJ7A 4C5RA 1Z4KA 2RJRA 4A15A 2JARA 1B8FA 1Y2MA 2O7FA 1XL8A 5M0IA 3F4SA 3OCEA 2I7DA 4V2RA 4MX2A 3KDZA 3RRPA 2X75A 4APBA 5EYVA 2O7DA 3GTDA 1C3UA 1FUPA 1VDKA 1K62A 4C5SA 1IW7D 3E04A 1YISA 1KQ7A 3BHGA 2J91A 1YFEA 1Z4IA 3U19A 3NZ4A 1U16A 1K7WA 1Q92A 3BWVA 4MWOA 3CRVA 5F91A 4FFXA 2PTQA 4FLCA 2JAOA 5D6BA 3CI0K 2FELA 2PFMA 3CRW1 4IQJM 4ADLA 4BABA 1MH9A 1FURA 3R6YA 4L6CA 4V2QA 2NYNA 4C5UA 1T6PA 1J3UA 2RCNA 3OCFA 4L6AA 1Z4PX 4L57A 3C8TA 3QBPA 1HY0A 2D27A 2YV5A 1XMDA 1XLYA 1U15A 1TJVA 1W27A 2O6YA 1XWOA 4WNLA 1GK2A 4C6GA 1XMCA 3F4TA 2RJSA 4YIHA 1YFMA 1Q91A 2VD6A 2OHYA 1RE5A 1AUWA 2E9FA 2JAUA 4MUMA 3UNVA 4YIKA 3R6QA 2FENA 2O7BA 2YIIA 4BAAA 3GZHA 3KDYA 2QGAB 3F4RA 4CQ5A 1T9HA 1U0LA 4EEIA 2O7EA 2JAWA 3NO9A 1TJUA 2FUSA 5HW2A 1C3CA 2VL7A 5EYTA 2QVEA 2HVGA 1Z4MA 1Q5NA 4NSLA 1GK3A 1GKJA 1EB4A
chains in the Genus database with same CATH topology
1DOFA 2O78A 4HGVA 4EFCA 2NYFA 1JSWA 3R6VA 1TJWA 3CZOA 4NLEA 1FUQA 3RD8A 4APAA 3TV2A 2PTRA 4ADMA 1T6JA 1GKMA 1DCNA 1I0AA 1HY1A 1FUOA 2PTSA 5F92A 1TJ7A 4C5RA 2RJRA 1B8FA 1Y2MA 2O7FA 3OCEA 4V2RA 4MX2A 3KDZA 3RRPA 2X75A 4APBA 5EYVA 2O7DA 3GTDA 1C3UA 1FUPA 1VDKA 1K62A 4C5SA 3E04A 1YISA 1KQ7A 3BHGA 2J91A 1YFEA 3NZ4A 1U16A 1K7WA 5F91A 4FFXA 2PTQA 4FLCA 5D6BA 2PFMA 4ADLA 4BABA 1FURA 3R6YA 4V2QA 2NYNA 4C5UA 1T6PA 1J3UA 3OCFA 3C8TA 3QBPA 1HY0A 1U15A 1TJVA 1W27A 2O6YA 1XWOA 1GK2A 4C6GA 2RJSA 1YFMA 2VD6A 2OHYA 1RE5A 1AUWA 2E9FA 3UNVA 3R6QA 2O7BA 2YIIA 4BAAA 3GZHA 3KDYA 2QGAB 4CQ5A 4EEIA 2O7EA 3NO9A 1TJUA 2FUSA 5HW2A 1C3CA 5EYTA 2QVEA 2HVGA 1Q5NA 4NSLA 1GK3A 1GKJA 1EB4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DOF A;  2O78 A;  4HGV A;  4EFC A;  2NYF A;  1JSW A;  3R6V A;  1TJW A;  3CZO A;  4NLE A;  1FUQ A;  3RD8 A;  4APA A;  3TV2 A;  2PTR A;  4ADM A;  1T6J A;  1GKM A;  1DCN A;  1I0A A;  1HY1 A;  1FUO A;  2PTS A;  5F92 A;  1TJ7 A;  4C5R A;  2RJR A;  1B8F A;  1Y2M A;  2O7F A;  3OCE A;  4V2R A;  4MX2 A;  3KDZ A;  3RRP A;  2X75 A;  4APB A;  5EYV A;  2O7D A;  3GTD A;  1C3U A;  1FUP A;  1VDK A;  1K62 A;  4C5S A;  3E04 A;  1YIS A;  1KQ7 A;  3BHG A;  2J91 A;  1YFE A;  3NZ4 A;  1U16 A;  1K7W A;  5F91 A;  4FFX A;  2PTQ A;  4FLC A;  5D6B A;  2PFM A;  4ADL A;  4BAB A;  1FUR A;  3R6Y A;  4V2Q A;  2NYN A;  4C5U A;  1T6P A;  1J3U A;  3OCF A;  3C8T A;  3QBP A;  1HY0 A;  1U15 A;  1TJV A;  1W27 A;  2O6Y A;  1XWO A;  1GK2 A;  4C6G A;  2RJS A;  1YFM A;  2VD6 A;  2OHY A;  1RE5 A;  1AUW A;  2E9F A;  3UNV A;  3R6Q A;  2O7B A;  2YII A;  4BAA A;  3GZH A;  3KDY A;  2QGA B;  4CQ5 A;  4EEI A;  2O7E A;  3NO9 A;  1TJU A;  2FUS A;  5HW2 A;  1C3C A;  5EYT A;  2QVE A;  2HVG A;  1Q5N A;  4NSL A;  1GK3 A;  1GKJ A;  1EB4 A; 
#chains in the Genus database with same CATH topology
 1DOF A;  5H8W A;  2O78 A;  4HGV A;  4EFC A;  2NYF A;  1JSW A;  3R6V A;  1TJW A;  3CZO A;  1Z4J A;  4NLE A;  5M0J A;  1FUQ A;  3RD8 A;  1Z4Q A;  4APA A;  4NFL A;  3TV2 A;  1XL7 A;  2PTR A;  4ADM A;  1T6J A;  1GKM A;  2VSF A;  4E88 A;  1Z4L A;  1DCN A;  1I0A A;  1HY1 A;  2D28 C;  3U13 A;  1FUO A;  2PTS A;  5F92 A;  1TJ7 A;  4C5R A;  1Z4K A;  2RJR A;  4A15 A;  2JAR A;  1B8F A;  1Y2M A;  2O7F A;  1XL8 A;  5M0I A;  3F4S A;  3OCE A;  2I7D A;  4V2R A;  4MX2 A;  3KDZ A;  3RRP A;  2X75 A;  4APB A;  5EYV A;  2O7D A;  3GTD A;  1C3U A;  1FUP A;  1VDK A;  1K62 A;  4C5S A;  1IW7 D;  3E04 A;  1YIS A;  1KQ7 A;  3BHG A;  2J91 A;  1YFE A;  1Z4I A;  3U19 A;  3NZ4 A;  1U16 A;  1K7W A;  1Q92 A;  3BWV A;  4MWO A;  3CRV A;  5F91 A;  4FFX A;  2PTQ A;  4FLC A;  2JAO A;  5D6B A;  3CI0 K;  2FEL A;  2PFM A;  3CRW 1;  4IQJ M;  4ADL A;  4BAB A;  1MH9 A;  1FUR A;  3R6Y A;  4L6C A;  4V2Q A;  2NYN A;  4C5U A;  1T6P A;  1J3U A;  2RCN A;  3OCF A;  4L6A A;  1Z4P X;  4L57 A;  3C8T A;  3QBP A;  1HY0 A;  2D27 A;  2YV5 A;  1XMD A;  1XLY A;  1U15 A;  1TJV A;  1W27 A;  2O6Y A;  1XWO A;  4WNL A;  1GK2 A;  4C6G A;  1XMC A;  3F4T A;  2RJS A;  4YIH A;  1YFM A;  1Q91 A;  2VD6 A;  2OHY A;  1RE5 A;  1AUW A;  2E9F A;  2JAU A;  4MUM A;  3UNV A;  4YIK A;  3R6Q A;  2FEN A;  2O7B A;  2YII A;  4BAA A;  3GZH A;  3KDY A;  2QGA B;  3F4R A;  4CQ5 A;  1T9H A;  1U0L A;  4EEI A;  2O7E A;  2JAW A;  3NO9 A;  1TJU A;  2FUS A;  5HW2 A;  1C3C A;  2VL7 A;  5EYT A;  2QVE A;  2HVG A;  1Z4M A;  1Q5N A;  4NSL A;  1GK3 A;  1GKJ A;  1EB4 A; 
#chains in the Genus database with same CATH homology
 1DOF A;  2O78 A;  4HGV A;  4EFC A;  2NYF A;  1JSW A;  3R6V A;  1TJW A;  3CZO A;  4NLE A;  1FUQ A;  3RD8 A;  4APA A;  3TV2 A;  2PTR A;  4ADM A;  1T6J A;  1GKM A;  1DCN A;  1I0A A;  1HY1 A;  1FUO A;  2PTS A;  5F92 A;  1TJ7 A;  4C5R A;  2RJR A;  1B8F A;  1Y2M A;  2O7F A;  3OCE A;  4V2R A;  4MX2 A;  3KDZ A;  3RRP A;  2X75 A;  4APB A;  5EYV A;  2O7D A;  3GTD A;  1C3U A;  1FUP A;  1VDK A;  1K62 A;  4C5S A;  3E04 A;  1YIS A;  1KQ7 A;  3BHG A;  2J91 A;  1YFE A;  3NZ4 A;  1U16 A;  1K7W A;  5F91 A;  4FFX A;  2PTQ A;  4FLC A;  5D6B A;  2PFM A;  4ADL A;  4BAB A;  1FUR A;  3R6Y A;  4V2Q A;  2NYN A;  4C5U A;  1T6P A;  1J3U A;  3OCF A;  3C8T A;  3QBP A;  1HY0 A;  1U15 A;  1TJV A;  1W27 A;  2O6Y A;  1XWO A;  1GK2 A;  4C6G A;  2RJS A;  1YFM A;  2VD6 A;  2OHY A;  1RE5 A;  1AUW A;  2E9F A;  3UNV A;  3R6Q A;  2O7B A;  2YII A;  4BAA A;  3GZH A;  3KDY A;  2QGA B;  4CQ5 A;  4EEI A;  2O7E A;  3NO9 A;  1TJU A;  2FUS A;  5HW2 A;  1C3C A;  5EYT A;  2QVE A;  2HVG A;  1Q5N A;  4NSL A;  1GK3 A;  1GKJ A;  1EB4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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