3KDYA

X-ray crystal structure of tyrosine aminomutase mutant construct
Total Genus 195
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
195
sequence length
527
structure length
526
Chain Sequence
VPVSVDGETLTVEAVRRVAEERATVDVPAESIAKAQKSREIFEGIAEQNIPIYGVTTGYGAMIYMQVDKSKEVELQTNLVRSHSAGVGPLFAEDEARAIVAARLNTLAKGHSAVRPIILERLAQYLNEGITPAIPEIGSLGDLAPLSHVASTLIGEGYVLRDGRPVETAQVLAERGIEPLELRFKEGLALINGTSGMTGLGSLVVGRALEQAQQAEIVTALLIEAVRGSTSPFLAEGHDIARPHEGQIDTAANMRALMRGSGLTVEHADLRRELQKDKEAGKDVQRSEIYLQKAYSLRAIPQVVGAVRDTLYHARHKLRIELNSANDNPLFFEGKEIFHGANFHGQPIAFAMDFVTIALTQLGVLAERQINRVLNRHLSYGLPEFLVSGDPGLHSGFAGAQYPATALVAENRTIGPASTQSVPSNGDNQDVVSMGLISARNARRVLSNNNKILAVEYLAAAQAVDISGRFDGLSPAAKATYEAVRRLVPTLGVDRYMADDIELVADALSRGEFLRAIARETDIQLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Probing the active site of MIO-dependent aminomutases, key catalysts in the biosynthesis of beta-amino acids incorporated in secondary metabolites
pubmed doi rcsb
source organism Streptomyces globisporus
molecule tags Lyase
molecule keywords Histidine ammonia-lyase
total genus 195
structure length 526
sequence length 527
chains with identical sequence B
ec nomenclature ec 4.3.1.23: Tyrosine ammonia-lyase.
pdb deposition date 2009-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3kdyA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3kdyA02
1K62A 2PTRA 1TJVA 4BAAA 2PFMA 3R6VA 4V2RA 4C5SA 1GKJA 3OCFA 4ADLA 5F91A 2O7BA 2QVEA 1U16A 1EB4A 1YFEA 1FUQA 3E04A 1W27A 1YISA 1I0AA 1GK2A 2O7EA 3NO9A 1YFMA 1DCNA 3OCEA 4MX2A 4C5UA 1VDKA 1T6JA 1C3UA 2PTQA 3RRPA 2PTSA 2E9FA 1FUPA 3CZOA 1KQ7A 1B8FA 2J91A 1GKMA 1TJWA 4NSLA 3TV2A 4ADMA 4BABA 2RJRA 2QGAB 4V2QA 4C6GA 1C3CA 4NLEA 1TJ7A 3KDZA 2NYNA 1DOFA 4CQ5A 5D6BA 3R6YA 1Y2MA 4EEIA 4APBA 2O7FA 1RE5A 3UNVA 5EYVA 4HGVA 1Q5NA 1FURA 4EFCA 1T6PA 1GK3A 2NYFA 1J3UA 2O6YA 2O78A 3NZ4A 4FLCA 3R6QA 2FUSA 1AUWA 1JSWA 2YIIA 1HY0A 3GTDA 1K7WA 3BHGA 5HW2A 5F92A 1HY1A 3RD8A 3KDYA 1FUOA 2OHYA 4C5RA 1TJUA 3QBPA 1XWOA 2HVGA 5EYTA 2VD6A 3C8TA 2X75A 4APAA 3GZHA 2O7DA 2RJSA 1U15A 4FFXA
chains in the Genus database with same CATH superfamily
1K62A 2PTRA 1TJVA 1XL8A 4BAAA 4A15A 2PFMA 3R6VA 4V2RA 4C5SA 1GKJA 2VSFA 3OCFA 4ADLA 5F91A 5M0JA 2O7BA 2QVEA 1U16A 1EB4A 1YFEA 1FUQA 3E04A 1W27A 1YISA 2FENA 1I0AA 1GK2A 2O7EA 3NO9A 1YFMA 1DCNA 3OCEA 3CRW1 4MX2A 4C5UA 1VDKA 1T6JA 1C3UA 1XMDA 2PTQA 3RRPA 2PTSA 2E9FA 1FUPA 3CZOA 1KQ7A 1B8FA 2J91A 1GKMA 1TJWA 4NSLA 5H8WA 3TV2A 4ADMA 4BABA 2RJRA 3CRVA 2QGAB 4V2QA 5M0IA 4C6GA 1C3CA 4NLEA 1TJ7A 3KDZA 2NYNA 1DOFA 4CQ5A 1XMCA 5D6BA 3R6YA 1Y2MA 4EEIA 4APBA 2O7FA 1RE5A 3UNVA 5EYVA 4HGVA 1Q5NA 1FURA 4EFCA 1T6PA 1GK3A 2NYFA 1J3UA 2O6YA 2O78A 2VL7A 3NZ4A 4FLCA 3R6QA 2FUSA 1AUWA 4WNLA 1JSWA 2YIIA 1HY0A 3GTDA 1K7WA 3BHGA 5HW2A 2FELA 5F92A 1HY1A 3RD8A 3KDYA 1FUOA 2OHYA 4C5RA 1XLYA 1TJUA 3QBPA 1XL7A 1XWOA 2HVGA 5EYTA 2VD6A 3C8TA 2X75A 4APAA 3GZHA 2O7DA 2RJSA 1U15A 4FFXA
chains in the Genus database with same CATH topology
1K62A 2PTRA 1TJVA 4BAAA 2PFMA 3R6VA 4V2RA 4C5SA 1GKJA 3OCFA 4ADLA 5F91A 2O7BA 2QVEA 1U16A 1EB4A 1YFEA 1FUQA 3E04A 1W27A 1YISA 1I0AA 1GK2A 2O7EA 3NO9A 1YFMA 1DCNA 3OCEA 4MX2A 4C5UA 1VDKA 1T6JA 1C3UA 2PTQA 3RRPA 2PTSA 2E9FA 1FUPA 3CZOA 1KQ7A 1B8FA 2J91A 1GKMA 1TJWA 4NSLA 3TV2A 4ADMA 4BABA 2RJRA 2QGAB 4V2QA 4C6GA 1C3CA 4NLEA 1TJ7A 3KDZA 2NYNA 1DOFA 4CQ5A 5D6BA 3R6YA 1Y2MA 4EEIA 4APBA 2O7FA 1RE5A 3UNVA 5EYVA 4HGVA 1Q5NA 1FURA 4EFCA 1T6PA 1GK3A 2NYFA 1J3UA 2O6YA 2O78A 3NZ4A 4FLCA 3R6QA 2FUSA 1AUWA 1JSWA 2YIIA 1HY0A 3GTDA 1K7WA 3BHGA 5HW2A 5F92A 1HY1A 3RD8A 3KDYA 1FUOA 2OHYA 4C5RA 1TJUA 3QBPA 1XWOA 2HVGA 5EYTA 2VD6A 3C8TA 2X75A 4APAA 3GZHA 2O7DA 2RJSA 1U15A 4FFXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1K62 A;  2PTR A;  1TJV A;  4BAA A;  2PFM A;  3R6V A;  4V2R A;  4C5S A;  1GKJ A;  3OCF A;  4ADL A;  5F91 A;  2O7B A;  2QVE A;  1U16 A;  1EB4 A;  1YFE A;  1FUQ A;  3E04 A;  1W27 A;  1YIS A;  1I0A A;  1GK2 A;  2O7E A;  3NO9 A;  1YFM A;  1DCN A;  3OCE A;  4MX2 A;  4C5U A;  1VDK A;  1T6J A;  1C3U A;  2PTQ A;  3RRP A;  2PTS A;  2E9F A;  1FUP A;  3CZO A;  1KQ7 A;  1B8F A;  2J91 A;  1GKM A;  1TJW A;  4NSL A;  3TV2 A;  4ADM A;  4BAB A;  2RJR A;  2QGA B;  4V2Q A;  4C6G A;  1C3C A;  4NLE A;  1TJ7 A;  3KDZ A;  2NYN A;  1DOF A;  4CQ5 A;  5D6B A;  3R6Y A;  1Y2M A;  4EEI A;  4APB A;  2O7F A;  1RE5 A;  3UNV A;  5EYV A;  4HGV A;  1Q5N A;  1FUR A;  4EFC A;  1T6P A;  1GK3 A;  2NYF A;  1J3U A;  2O6Y A;  2O78 A;  3NZ4 A;  4FLC A;  3R6Q A;  2FUS A;  1AUW A;  1JSW A;  2YII A;  1HY0 A;  3GTD A;  1K7W A;  3BHG A;  5HW2 A;  5F92 A;  1HY1 A;  3RD8 A;  3KDY A;  1FUO A;  2OHY A;  4C5R A;  1TJU A;  3QBP A;  1XWO A;  2HVG A;  5EYT A;  2VD6 A;  3C8T A;  2X75 A;  4APA A;  3GZH A;  2O7D A;  2RJS A;  1U15 A;  4FFX A; 
#chains in the Genus database with same CATH topology
 1K62 A;  2PTR A;  1TJV A;  1XL8 A;  4BAA A;  4A15 A;  2PFM A;  3R6V A;  4V2R A;  4C5S A;  1GKJ A;  2VSF A;  3OCF A;  4ADL A;  5F91 A;  5M0J A;  2O7B A;  2QVE A;  1U16 A;  1EB4 A;  1YFE A;  1FUQ A;  3E04 A;  1W27 A;  1YIS A;  2FEN A;  1I0A A;  1GK2 A;  2O7E A;  3NO9 A;  1YFM A;  1DCN A;  3OCE A;  3CRW 1;  4MX2 A;  4C5U A;  1VDK A;  1T6J A;  1C3U A;  1XMD A;  2PTQ A;  3RRP A;  2PTS A;  2E9F A;  1FUP A;  3CZO A;  1KQ7 A;  1B8F A;  2J91 A;  1GKM A;  1TJW A;  4NSL A;  5H8W A;  3TV2 A;  4ADM A;  4BAB A;  2RJR A;  3CRV A;  2QGA B;  4V2Q A;  5M0I A;  4C6G A;  1C3C A;  4NLE A;  1TJ7 A;  3KDZ A;  2NYN A;  1DOF A;  4CQ5 A;  1XMC A;  5D6B A;  3R6Y A;  1Y2M A;  4EEI A;  4APB A;  2O7F A;  1RE5 A;  3UNV A;  5EYV A;  4HGV A;  1Q5N A;  1FUR A;  4EFC A;  1T6P A;  1GK3 A;  2NYF A;  1J3U A;  2O6Y A;  2O78 A;  2VL7 A;  3NZ4 A;  4FLC A;  3R6Q A;  2FUS A;  1AUW A;  4WNL A;  1JSW A;  2YII A;  1HY0 A;  3GTD A;  1K7W A;  3BHG A;  5HW2 A;  2FEL A;  5F92 A;  1HY1 A;  3RD8 A;  3KDY A;  1FUO A;  2OHY A;  4C5R A;  1XLY A;  1TJU A;  3QBP A;  1XL7 A;  1XWO A;  2HVG A;  5EYT A;  2VD6 A;  3C8T A;  2X75 A;  4APA A;  3GZH A;  2O7D A;  2RJS A;  1U15 A;  4FFX A; 
#chains in the Genus database with same CATH homology
 1K62 A;  2PTR A;  1TJV A;  4BAA A;  2PFM A;  3R6V A;  4V2R A;  4C5S A;  1GKJ A;  3OCF A;  4ADL A;  5F91 A;  2O7B A;  2QVE A;  1U16 A;  1EB4 A;  1YFE A;  1FUQ A;  3E04 A;  1W27 A;  1YIS A;  1I0A A;  1GK2 A;  2O7E A;  3NO9 A;  1YFM A;  1DCN A;  3OCE A;  4MX2 A;  4C5U A;  1VDK A;  1T6J A;  1C3U A;  2PTQ A;  3RRP A;  2PTS A;  2E9F A;  1FUP A;  3CZO A;  1KQ7 A;  1B8F A;  2J91 A;  1GKM A;  1TJW A;  4NSL A;  3TV2 A;  4ADM A;  4BAB A;  2RJR A;  2QGA B;  4V2Q A;  4C6G A;  1C3C A;  4NLE A;  1TJ7 A;  3KDZ A;  2NYN A;  1DOF A;  4CQ5 A;  5D6B A;  3R6Y A;  1Y2M A;  4EEI A;  4APB A;  2O7F A;  1RE5 A;  3UNV A;  5EYV A;  4HGV A;  1Q5N A;  1FUR A;  4EFC A;  1T6P A;  1GK3 A;  2NYF A;  1J3U A;  2O6Y A;  2O78 A;  3NZ4 A;  4FLC A;  3R6Q A;  2FUS A;  1AUW A;  1JSW A;  2YII A;  1HY0 A;  3GTD A;  1K7W A;  3BHG A;  5HW2 A;  5F92 A;  1HY1 A;  3RD8 A;  3KDY A;  1FUO A;  2OHY A;  4C5R A;  1TJU A;  3QBP A;  1XWO A;  2HVG A;  5EYT A;  2VD6 A;  3C8T A;  2X75 A;  4APA A;  3GZH A;  2O7D A;  2RJS A;  1U15 A;  4FFX A; 
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