3KDYA

X-ray crystal structure of tyrosine aminomutase mutant construct
Total Genus 195
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
195
sequence length
527
structure length
526
Chain Sequence
VPVSVDGETLTVEAVRRVAEERATVDVPAESIAKAQKSREIFEGIAEQNIPIYGVTTGYGAMIYMQVDKSKEVELQTNLVRSHSAGVGPLFAEDEARAIVAARLNTLAKGHSAVRPIILERLAQYLNEGITPAIPEIGSLGDLAPLSHVASTLIGEGYVLRDGRPVETAQVLAERGIEPLELRFKEGLALINGTSGMTGLGSLVVGRALEQAQQAEIVTALLIEAVRGSTSPFLAEGHDIARPHEGQIDTAANMRALMRGSGLTVEHADLRRELQKDKEAGKDVQRSEIYLQKAYSLRAIPQVVGAVRDTLYHARHKLRIELNSANDNPLFFEGKEIFHGANFHGQPIAFAMDFVTIALTQLGVLAERQINRVLNRHLSYGLPEFLVSGDPGLHSGFAGAQYPATALVAENRTIGPASTQSVPSNGDNQDVVSMGLISARNARRVLSNNNKILAVEYLAAAQAVDISGRFDGLSPAAKATYEAVRRLVPTLGVDRYMADDIELVADALSRGEFLRAIARETDIQLR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule keywords Histidine ammonia-lyase
publication title Probing the active site of MIO-dependent aminomutases, key catalysts in the biosynthesis of beta-amino acids incorporated in secondary metabolites
pubmed doi rcsb
source organism Streptomyces globisporus
molecule tags Lyase
total genus 195
structure length 526
sequence length 527
chains with identical sequence B
ec nomenclature ec 4.3.1.23: Tyrosine ammonia-lyase.
pdb deposition date 2009-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3kdyA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3kdyA02
5D6BA 2O78A 2FUSA 2QGAB 2O7FA 3OCFA 5HW2A 3R6YA 4V2QA 5F92A 1T6JA 1J3UA 2PTRA 4C6GA 4C5UA 3RD8A 1VDKA 4EFCA 2J91A 3R6QA 2O7DA 3KDZA 4BABA 1YFMA 1K62A 2HVGA 2RJRA 1T6PA 3BHGA 2OHYA 4HGVA 3NO9A 1TJUA 2YIIA 1K7WA 1YFEA 3NZ4A 4ADMA 1HY0A 1U16A 4FLCA 2QVEA 1EB4A 2O6YA 3KDYA 4C5SA 1DOFA 1GK2A 1I0AA 2O7BA 3E04A 5EYVA 5F91A 1TJWA 2VD6A 1TJ7A 1FURA 1DCNA 1Q5NA 1YISA 5EYTA 1KQ7A 1GKJA 1TJVA 1RE5A 2X75A 1XWOA 3UNVA 1GKMA 4MX2A 3GTDA 4APAA 3C8TA 1FUOA 4APBA 1JSWA 1B8FA 1C3UA 1Y2MA 1FUQA 4V2RA 3TV2A 1W27A 4ADLA 3CZOA 3GZHA 1FUPA 1GK3A 2PTSA 4CQ5A 2NYFA 4NLEA 2E9FA 1HY1A 2O7EA 2PTQA 4EEIA 1C3CA 3RRPA 4FFXA 4BAAA 4C5RA 3QBPA 1AUWA 2RJSA 1U15A 3OCEA 3R6VA 2NYNA 2PFMA 4NSLA
chains in the Genus database with same CATH superfamily
5D6BA 2FENA 2O78A 2FUSA 2QGAB 2O7FA 3OCFA 5HW2A 3R6YA 5M0JA 4V2QA 5F92A 1T6JA 1J3UA 2PTRA 4C6GA 4C5UA 3RD8A 1VDKA 4EFCA 4A15A 2J91A 3R6QA 2O7DA 3KDZA 4BABA 1YFMA 1K62A 2HVGA 2RJRA 1T6PA 3BHGA 2OHYA 4HGVA 3NO9A 1XMDA 3CRW1 1TJUA 2YIIA 1K7WA 1YFEA 3NZ4A 4ADMA 1HY0A 1U16A 4FLCA 2QVEA 1EB4A 2O6YA 5M0IA 3KDYA 4C5SA 1DOFA 1GK2A 1I0AA 2O7BA 3E04A 5EYVA 2VSFA 5F91A 1TJWA 2VD6A 1TJ7A 4WNLA 1FURA 1XL7A 1DCNA 1Q5NA 1YISA 5EYTA 1KQ7A 1GKJA 1TJVA 1RE5A 2X75A 1XWOA 3UNVA 1GKMA 4MX2A 3GTDA 5H8WA 4APAA 3C8TA 1FUOA 2FELA 4APBA 1JSWA 1B8FA 1C3UA 1Y2MA 1FUQA 4V2RA 3TV2A 1W27A 4ADLA 1XMCA 3CZOA 3GZHA 1FUPA 1GK3A 2PTSA 4CQ5A 2NYFA 4NLEA 2E9FA 1HY1A 2O7EA 2PTQA 4EEIA 1C3CA 2VL7A 3RRPA 4FFXA 4BAAA 4C5RA 3QBPA 3CRVA 1XL8A 1AUWA 1XLYA 2RJSA 1U15A 3OCEA 3R6VA 2NYNA 2PFMA 4NSLA
chains in the Genus database with same CATH topology
5D6BA 2O78A 2FUSA 2QGAB 2O7FA 3OCFA 5HW2A 3R6YA 4V2QA 5F92A 1T6JA 1J3UA 2PTRA 4C6GA 4C5UA 3RD8A 1VDKA 4EFCA 2J91A 3R6QA 2O7DA 3KDZA 4BABA 1YFMA 1K62A 2HVGA 2RJRA 1T6PA 3BHGA 2OHYA 4HGVA 3NO9A 1TJUA 2YIIA 1K7WA 1YFEA 3NZ4A 4ADMA 1HY0A 1U16A 4FLCA 2QVEA 1EB4A 2O6YA 3KDYA 4C5SA 1DOFA 1GK2A 1I0AA 2O7BA 3E04A 5EYVA 5F91A 1TJWA 2VD6A 1TJ7A 1FURA 1DCNA 1Q5NA 1YISA 5EYTA 1KQ7A 1GKJA 1TJVA 1RE5A 2X75A 1XWOA 3UNVA 1GKMA 4MX2A 3GTDA 4APAA 3C8TA 1FUOA 4APBA 1JSWA 1B8FA 1C3UA 1Y2MA 1FUQA 4V2RA 3TV2A 1W27A 4ADLA 3CZOA 3GZHA 1FUPA 1GK3A 2PTSA 4CQ5A 2NYFA 4NLEA 2E9FA 1HY1A 2O7EA 2PTQA 4EEIA 1C3CA 3RRPA 4FFXA 4BAAA 4C5RA 3QBPA 1AUWA 2RJSA 1U15A 3OCEA 3R6VA 2NYNA 2PFMA 4NSLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5D6B A;  2O78 A;  2FUS A;  2QGA B;  2O7F A;  3OCF A;  5HW2 A;  3R6Y A;  4V2Q A;  5F92 A;  1T6J A;  1J3U A;  2PTR A;  4C6G A;  4C5U A;  3RD8 A;  1VDK A;  4EFC A;  2J91 A;  3R6Q A;  2O7D A;  3KDZ A;  4BAB A;  1YFM A;  1K62 A;  2HVG A;  2RJR A;  1T6P A;  3BHG A;  2OHY A;  4HGV A;  3NO9 A;  1TJU A;  2YII A;  1K7W A;  1YFE A;  3NZ4 A;  4ADM A;  1HY0 A;  1U16 A;  4FLC A;  2QVE A;  1EB4 A;  2O6Y A;  3KDY A;  4C5S A;  1DOF A;  1GK2 A;  1I0A A;  2O7B A;  3E04 A;  5EYV A;  5F91 A;  1TJW A;  2VD6 A;  1TJ7 A;  1FUR A;  1DCN A;  1Q5N A;  1YIS A;  5EYT A;  1KQ7 A;  1GKJ A;  1TJV A;  1RE5 A;  2X75 A;  1XWO A;  3UNV A;  1GKM A;  4MX2 A;  3GTD A;  4APA A;  3C8T A;  1FUO A;  4APB A;  1JSW A;  1B8F A;  1C3U A;  1Y2M A;  1FUQ A;  4V2R A;  3TV2 A;  1W27 A;  4ADL A;  3CZO A;  3GZH A;  1FUP A;  1GK3 A;  2PTS A;  4CQ5 A;  2NYF A;  4NLE A;  2E9F A;  1HY1 A;  2O7E A;  2PTQ A;  4EEI A;  1C3C A;  3RRP A;  4FFX A;  4BAA A;  4C5R A;  3QBP A;  1AUW A;  2RJS A;  1U15 A;  3OCE A;  3R6V A;  2NYN A;  2PFM A;  4NSL A; 
#chains in the Genus database with same CATH topology
 5D6B A;  2FEN A;  2O78 A;  2FUS A;  2QGA B;  2O7F A;  3OCF A;  5HW2 A;  3R6Y A;  5M0J A;  4V2Q A;  5F92 A;  1T6J A;  1J3U A;  2PTR A;  4C6G A;  4C5U A;  3RD8 A;  1VDK A;  4EFC A;  4A15 A;  2J91 A;  3R6Q A;  2O7D A;  3KDZ A;  4BAB A;  1YFM A;  1K62 A;  2HVG A;  2RJR A;  1T6P A;  3BHG A;  2OHY A;  4HGV A;  3NO9 A;  1XMD A;  3CRW 1;  1TJU A;  2YII A;  1K7W A;  1YFE A;  3NZ4 A;  4ADM A;  1HY0 A;  1U16 A;  4FLC A;  2QVE A;  1EB4 A;  2O6Y A;  5M0I A;  3KDY A;  4C5S A;  1DOF A;  1GK2 A;  1I0A A;  2O7B A;  3E04 A;  5EYV A;  2VSF A;  5F91 A;  1TJW A;  2VD6 A;  1TJ7 A;  4WNL A;  1FUR A;  1XL7 A;  1DCN A;  1Q5N A;  1YIS A;  5EYT A;  1KQ7 A;  1GKJ A;  1TJV A;  1RE5 A;  2X75 A;  1XWO A;  3UNV A;  1GKM A;  4MX2 A;  3GTD A;  5H8W A;  4APA A;  3C8T A;  1FUO A;  2FEL A;  4APB A;  1JSW A;  1B8F A;  1C3U A;  1Y2M A;  1FUQ A;  4V2R A;  3TV2 A;  1W27 A;  4ADL A;  1XMC A;  3CZO A;  3GZH A;  1FUP A;  1GK3 A;  2PTS A;  4CQ5 A;  2NYF A;  4NLE A;  2E9F A;  1HY1 A;  2O7E A;  2PTQ A;  4EEI A;  1C3C A;  2VL7 A;  3RRP A;  4FFX A;  4BAA A;  4C5R A;  3QBP A;  3CRV A;  1XL8 A;  1AUW A;  1XLY A;  2RJS A;  1U15 A;  3OCE A;  3R6V A;  2NYN A;  2PFM A;  4NSL A; 
#chains in the Genus database with same CATH homology
 5D6B A;  2O78 A;  2FUS A;  2QGA B;  2O7F A;  3OCF A;  5HW2 A;  3R6Y A;  4V2Q A;  5F92 A;  1T6J A;  1J3U A;  2PTR A;  4C6G A;  4C5U A;  3RD8 A;  1VDK A;  4EFC A;  2J91 A;  3R6Q A;  2O7D A;  3KDZ A;  4BAB A;  1YFM A;  1K62 A;  2HVG A;  2RJR A;  1T6P A;  3BHG A;  2OHY A;  4HGV A;  3NO9 A;  1TJU A;  2YII A;  1K7W A;  1YFE A;  3NZ4 A;  4ADM A;  1HY0 A;  1U16 A;  4FLC A;  2QVE A;  1EB4 A;  2O6Y A;  3KDY A;  4C5S A;  1DOF A;  1GK2 A;  1I0A A;  2O7B A;  3E04 A;  5EYV A;  5F91 A;  1TJW A;  2VD6 A;  1TJ7 A;  1FUR A;  1DCN A;  1Q5N A;  1YIS A;  5EYT A;  1KQ7 A;  1GKJ A;  1TJV A;  1RE5 A;  2X75 A;  1XWO A;  3UNV A;  1GKM A;  4MX2 A;  3GTD A;  4APA A;  3C8T A;  1FUO A;  4APB A;  1JSW A;  1B8F A;  1C3U A;  1Y2M A;  1FUQ A;  4V2R A;  3TV2 A;  1W27 A;  4ADL A;  3CZO A;  3GZH A;  1FUP A;  1GK3 A;  2PTS A;  4CQ5 A;  2NYF A;  4NLE A;  2E9F A;  1HY1 A;  2O7E A;  2PTQ A;  4EEI A;  1C3C A;  3RRP A;  4FFX A;  4BAA A;  4C5R A;  3QBP A;  1AUW A;  2RJS A;  1U15 A;  3OCE A;  3R6V A;  2NYN A;  2PFM A;  4NSL A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...