3KDYA

X-ray crystal structure of tyrosine aminomutase mutant construct
Total Genus 195
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
195
sequence length
527
structure length
526
Chain Sequence
VPVSVDGETLTVEAVRRVAEERATVDVPAESIAKAQKSREIFEGIAEQNIPIYGVTTGYGAMIYMQVDKSKEVELQTNLVRSHSAGVGPLFAEDEARAIVAARLNTLAKGHSAVRPIILERLAQYLNEGITPAIPEIGSLGDLAPLSHVASTLIGEGYVLRDGRPVETAQVLAERGIEPLELRFKEGLALINGTSGMTGLGSLVVGRALEQAQQAEIVTALLIEAVRGSTSPFLAEGHDIARPHEGQIDTAANMRALMRGSGLTVEHADLRRELQKDKEAGKDVQRSEIYLQKAYSLRAIPQVVGAVRDTLYHARHKLRIELNSANDNPLFFEGKEIFHGANFHGQPIAFAMDFVTIALTQLGVLAERQINRVLNRHLSYGLPEFLVSGDPGLHSGFAGAQYPATALVAENRTIGPASTQSVPSNGDNQDVVSMGLISARNARRVLSNNNKILAVEYLAAAQAVDISGRFDGLSPAAKATYEAVRRLVPTLGVDRYMADDIELVADALSRGEFLRAIARETDIQLR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lyase
molecule keywords Histidine ammonia-lyase
publication title Probing the active site of MIO-dependent aminomutases, key catalysts in the biosynthesis of beta-amino acids incorporated in secondary metabolites
pubmed doi rcsb
source organism Streptomyces globisporus
total genus 195
structure length 526
sequence length 527
chains with identical sequence B
ec nomenclature ec 4.3.1.23: Tyrosine ammonia-lyase.
pdb deposition date 2009-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3kdyA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3kdyA02
2X75A 1YFEA 1FUQA 2RJSA 1JSWA 1RE5A 4C6GA 4HGVA 1T6PA 2O7FA 2PTQA 3BHGA 3R6QA 5F92A 2OHYA 3NO9A 1YISA 3GTDA 4C5UA 1VDKA 3KDZA 1GKMA 1C3UA 1U15A 1DCNA 3CZOA 1YFMA 2PFMA 1FURA 2PTSA 2PTRA 4NLEA 1TJVA 1HY0A 5HW2A 2NYFA 4C5RA 1K62A 2YIIA 4V2QA 4CQ5A 1GKJA 4EFCA 4MX2A 3OCEA 4APAA 5EYTA 1Y2MA 3C8TA 3RD8A 1C3CA 3TV2A 4EEIA 4BAAA 1B8FA 1Q5NA 4FFXA 4C5SA 2O6YA 2J91A 2E9FA 1K7WA 1KQ7A 5F91A 1FUOA 1T6JA 3NZ4A 4NSLA 2VD6A 1DOFA 4FLCA 3R6YA 1FUPA 1TJWA 3R6VA 1U16A 4APBA 1W27A 2NYNA 3OCFA 1HY1A 2HVGA 2O7BA 1EB4A 1GK2A 1TJ7A 1J3UA 3UNVA 3RRPA 1I0AA 5EYVA 1XWOA 2QVEA 1AUWA 3GZHA 5D6BA 1TJUA 2O7EA 3KDYA 4ADMA 3E04A 1GK3A 4V2RA 2O7DA 3QBPA 4ADLA 4BABA 2RJRA 2FUSA 2O78A 2QGAB
chains in the Genus database with same CATH superfamily
2VL7A 3CRW1 2X75A 1YFEA 1FUQA 2RJSA 1JSWA 1RE5A 4C6GA 2VSFA 4HGVA 1T6PA 2O7FA 2PTQA 3BHGA 1XL8A 5H8WA 1XLYA 3R6QA 5F92A 2OHYA 3NO9A 1YISA 3GTDA 2FENA 4C5UA 1VDKA 5M0JA 1XMCA 3KDZA 1GKMA 1C3UA 1U15A 1DCNA 3CZOA 1YFMA 2PFMA 1FURA 4WNLA 2PTSA 2PTRA 4NLEA 1TJVA 1HY0A 5HW2A 2NYFA 4C5RA 1K62A 2YIIA 4V2QA 4CQ5A 1GKJA 2FELA 5M0IA 4EFCA 4MX2A 3OCEA 4APAA 5EYTA 1Y2MA 3C8TA 3RD8A 1C3CA 3TV2A 4EEIA 4A15A 4BAAA 1B8FA 1Q5NA 4FFXA 4C5SA 2O6YA 2E9FA 2J91A 1K7WA 1KQ7A 5F91A 1FUOA 3CRVA 1XMDA 1T6JA 3NZ4A 4NSLA 2VD6A 1DOFA 4FLCA 3R6YA 1FUPA 1TJWA 3R6VA 1U16A 4APBA 1W27A 2NYNA 3OCFA 1HY1A 2HVGA 2O7BA 1EB4A 1GK2A 1TJ7A 1J3UA 3UNVA 3RRPA 1I0AA 5EYVA 1XWOA 2QVEA 1AUWA 3GZHA 5D6BA 1TJUA 2O7EA 1XL7A 3KDYA 4ADMA 3E04A 1GK3A 4V2RA 2O7DA 3QBPA 4ADLA 4BABA 2RJRA 2FUSA 2O78A 2QGAB
chains in the Genus database with same CATH topology
2X75A 1YFEA 1FUQA 2RJSA 1JSWA 1RE5A 4C6GA 4HGVA 1T6PA 2O7FA 2PTQA 3BHGA 3R6QA 5F92A 2OHYA 3NO9A 1YISA 3GTDA 4C5UA 1VDKA 3KDZA 1GKMA 1C3UA 1U15A 1DCNA 3CZOA 1YFMA 2PFMA 1FURA 2PTSA 2PTRA 4NLEA 1TJVA 1HY0A 5HW2A 2NYFA 4C5RA 1K62A 2YIIA 4V2QA 4CQ5A 1GKJA 4EFCA 4MX2A 3OCEA 4APAA 5EYTA 1Y2MA 3C8TA 3RD8A 1C3CA 3TV2A 4EEIA 4BAAA 1B8FA 1Q5NA 4FFXA 4C5SA 2O6YA 2J91A 2E9FA 1K7WA 1KQ7A 5F91A 1FUOA 1T6JA 3NZ4A 4NSLA 2VD6A 1DOFA 4FLCA 3R6YA 1FUPA 1TJWA 3R6VA 1U16A 4APBA 1W27A 2NYNA 3OCFA 1HY1A 2HVGA 2O7BA 1EB4A 1GK2A 1TJ7A 1J3UA 3UNVA 3RRPA 1I0AA 5EYVA 1XWOA 2QVEA 1AUWA 3GZHA 5D6BA 1TJUA 2O7EA 3KDYA 4ADMA 3E04A 1GK3A 4V2RA 2O7DA 3QBPA 4ADLA 4BABA 2RJRA 2FUSA 2O78A 2QGAB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2X75 A;  1YFE A;  1FUQ A;  2RJS A;  1JSW A;  1RE5 A;  4C6G A;  4HGV A;  1T6P A;  2O7F A;  2PTQ A;  3BHG A;  3R6Q A;  5F92 A;  2OHY A;  3NO9 A;  1YIS A;  3GTD A;  4C5U A;  1VDK A;  3KDZ A;  1GKM A;  1C3U A;  1U15 A;  1DCN A;  3CZO A;  1YFM A;  2PFM A;  1FUR A;  2PTS A;  2PTR A;  4NLE A;  1TJV A;  1HY0 A;  5HW2 A;  2NYF A;  4C5R A;  1K62 A;  2YII A;  4V2Q A;  4CQ5 A;  1GKJ A;  4EFC A;  4MX2 A;  3OCE A;  4APA A;  5EYT A;  1Y2M A;  3C8T A;  3RD8 A;  1C3C A;  3TV2 A;  4EEI A;  4BAA A;  1B8F A;  1Q5N A;  4FFX A;  4C5S A;  2O6Y A;  2J91 A;  2E9F A;  1K7W A;  1KQ7 A;  5F91 A;  1FUO A;  1T6J A;  3NZ4 A;  4NSL A;  2VD6 A;  1DOF A;  4FLC A;  3R6Y A;  1FUP A;  1TJW A;  3R6V A;  1U16 A;  4APB A;  1W27 A;  2NYN A;  3OCF A;  1HY1 A;  2HVG A;  2O7B A;  1EB4 A;  1GK2 A;  1TJ7 A;  1J3U A;  3UNV A;  3RRP A;  1I0A A;  5EYV A;  1XWO A;  2QVE A;  1AUW A;  3GZH A;  5D6B A;  1TJU A;  2O7E A;  3KDY A;  4ADM A;  3E04 A;  1GK3 A;  4V2R A;  2O7D A;  3QBP A;  4ADL A;  4BAB A;  2RJR A;  2FUS A;  2O78 A;  2QGA B; 
#chains in the Genus database with same CATH topology
 2VL7 A;  3CRW 1;  2X75 A;  1YFE A;  1FUQ A;  2RJS A;  1JSW A;  1RE5 A;  4C6G A;  2VSF A;  4HGV A;  1T6P A;  2O7F A;  2PTQ A;  3BHG A;  1XL8 A;  5H8W A;  1XLY A;  3R6Q A;  5F92 A;  2OHY A;  3NO9 A;  1YIS A;  3GTD A;  2FEN A;  4C5U A;  1VDK A;  5M0J A;  1XMC A;  3KDZ A;  1GKM A;  1C3U A;  1U15 A;  1DCN A;  3CZO A;  1YFM A;  2PFM A;  1FUR A;  4WNL A;  2PTS A;  2PTR A;  4NLE A;  1TJV A;  1HY0 A;  5HW2 A;  2NYF A;  4C5R A;  1K62 A;  2YII A;  4V2Q A;  4CQ5 A;  1GKJ A;  2FEL A;  5M0I A;  4EFC A;  4MX2 A;  3OCE A;  4APA A;  5EYT A;  1Y2M A;  3C8T A;  3RD8 A;  1C3C A;  3TV2 A;  4EEI A;  4A15 A;  4BAA A;  1B8F A;  1Q5N A;  4FFX A;  4C5S A;  2O6Y A;  2E9F A;  2J91 A;  1K7W A;  1KQ7 A;  5F91 A;  1FUO A;  3CRV A;  1XMD A;  1T6J A;  3NZ4 A;  4NSL A;  2VD6 A;  1DOF A;  4FLC A;  3R6Y A;  1FUP A;  1TJW A;  3R6V A;  1U16 A;  4APB A;  1W27 A;  2NYN A;  3OCF A;  1HY1 A;  2HVG A;  2O7B A;  1EB4 A;  1GK2 A;  1TJ7 A;  1J3U A;  3UNV A;  3RRP A;  1I0A A;  5EYV A;  1XWO A;  2QVE A;  1AUW A;  3GZH A;  5D6B A;  1TJU A;  2O7E A;  1XL7 A;  3KDY A;  4ADM A;  3E04 A;  1GK3 A;  4V2R A;  2O7D A;  3QBP A;  4ADL A;  4BAB A;  2RJR A;  2FUS A;  2O78 A;  2QGA B; 
#chains in the Genus database with same CATH homology
 2X75 A;  1YFE A;  1FUQ A;  2RJS A;  1JSW A;  1RE5 A;  4C6G A;  4HGV A;  1T6P A;  2O7F A;  2PTQ A;  3BHG A;  3R6Q A;  5F92 A;  2OHY A;  3NO9 A;  1YIS A;  3GTD A;  4C5U A;  1VDK A;  3KDZ A;  1GKM A;  1C3U A;  1U15 A;  1DCN A;  3CZO A;  1YFM A;  2PFM A;  1FUR A;  2PTS A;  2PTR A;  4NLE A;  1TJV A;  1HY0 A;  5HW2 A;  2NYF A;  4C5R A;  1K62 A;  2YII A;  4V2Q A;  4CQ5 A;  1GKJ A;  4EFC A;  4MX2 A;  3OCE A;  4APA A;  5EYT A;  1Y2M A;  3C8T A;  3RD8 A;  1C3C A;  3TV2 A;  4EEI A;  4BAA A;  1B8F A;  1Q5N A;  4FFX A;  4C5S A;  2O6Y A;  2J91 A;  2E9F A;  1K7W A;  1KQ7 A;  5F91 A;  1FUO A;  1T6J A;  3NZ4 A;  4NSL A;  2VD6 A;  1DOF A;  4FLC A;  3R6Y A;  1FUP A;  1TJW A;  3R6V A;  1U16 A;  4APB A;  1W27 A;  2NYN A;  3OCF A;  1HY1 A;  2HVG A;  2O7B A;  1EB4 A;  1GK2 A;  1TJ7 A;  1J3U A;  3UNV A;  3RRP A;  1I0A A;  5EYV A;  1XWO A;  2QVE A;  1AUW A;  3GZH A;  5D6B A;  1TJU A;  2O7E A;  3KDY A;  4ADM A;  3E04 A;  1GK3 A;  4V2R A;  2O7D A;  3QBP A;  4ADL A;  4BAB A;  2RJR A;  2FUS A;  2O78 A;  2QGA B; 
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