1FUPA

Fumarase with bound pyromellitic acid
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
sequence length
455
structure length
455
Chain Sequence
RSEKDSMGAIDVPADKLWGAQTQRSLEHFRISTEKMPTSLIHALALTKRAAAKVNEDLGLLSEEKASAIRQAADEVLAGQHDDEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGVRGMERKVHPNDDVNKSQSSNDVFPTAMHVAALLALRKQLIPQLKTLTQTLNEKSRAFADIVKIGRTHLQDATPLTLGQEISGWVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYARRVADELAVITCAPFVTAPNKFEALATCDALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEISIPENEPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHNFLQSVRLLADGMESFNKHCAVGIEPNRERINQLLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAALALGYLSEAEFDSWVRPEQM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystallographic studies of the catalytic and a second site in fumarase C from Escherichia coli.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Lyase
molecule keywords FUMARASE C
total genus 177
structure length 455
sequence length 455
chains with identical sequence B
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 1996-08-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 1fupA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1fupA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1fupA02
3NO9A 1XWOA 3UNVA 2VD6A 2YIIA 1I0AA 4EEIA 4ADLA 1U15A 1EB4A 2NYFA 3RRPA 4APAA 2HVGA 1RE5A 1TJVA 4FFXA 5HW2A 1GKJA 2OHYA 3R6YA 3QBPA 1TJ7A 2NYNA 1KQ7A 4C5RA 2O7FA 4V2RA 1J3UA 3RD8A 1W27A 3BHGA 1U16A 4CQ5A 1T6PA 5F92A 1GK2A 3GTDA 3KDYA 1HY1A 3R6QA 4ADMA 4NSLA 2QGAB 2O78A 1FUPA 3GZHA 2RJRA 1K7WA 1Q5NA 1GKMA 1YFEA 3TV2A 3KDZA 2O7EA 1HY0A 2O7BA 5F91A 4BAAA 1FUOA 1GK3A 4APBA 1FURA 5EYTA 1T6JA 4C5UA 3R6VA 1TJUA 3OCFA 1C3UA 2PTQA 1C3CA 1DOFA 4EFCA 1YISA 1Y2MA 2PTRA 3OCEA 5EYVA 2RJSA 1B8FA 3C8TA 5D6BA 2X75A 1FUQA 4FLCA 4BABA 2PTSA 4C6GA 1TJWA 2FUSA 4NLEA 1K62A 1DCNA 1JSWA 1YFMA 2J91A 2PFMA 3NZ4A 2O7DA 1VDKA 4MX2A 4HGVA 2QVEA 3CZOA 4C5SA 2O6YA 4V2QA 1AUWA 2E9FA 3E04A
chains in the Genus database with same CATH superfamily
3NO9A 3F4TA 1XWOA 1U0LA 3UNVA 1Z4QA 2D27A 2VD6A 2YIIA 1I0AA 4EEIA 2FENA 4ADLA 1U15A 1EB4A 2NYFA 3RRPA 1XMDA 4APAA 2HVGA 1RE5A 1TJVA 4IQJM 1Z4PX 2FELA 1Z4MA 4FFXA 5HW2A 1GKJA 2OHYA 3R6YA 3QBPA 1TJ7A 2NYNA 2VSFA 4L6CA 1KQ7A 2JAOA 4C5RA 2O7FA 2JARA 4V2RA 1XLYA 4WNLA 1XMCA 1Z4IA 4MUMA 3F4RA 1IW7D 2JAUA 1J3UA 1Q92A 2RCNA 3RD8A 1MH9A 1W27A 3BHGA 4NFLA 1U16A 1Q91A 4CQ5A 1T9HA 3U19A 1T6PA 2D28C 5F92A 1Z4LA 1GK2A 3GTDA 3KDYA 4MWOA 1HY1A 3R6QA 4ADMA 4NSLA 2QGAB 1FUPA 3GZHA 2O78A 2RJRA 1K7WA 3BWVA 1Q5NA 1GKMA 3CI0K 4YIHA 1YFEA 3TV2A 1XL8A 3CRVA 1Z4JA 3KDZA 2O7EA 1HY0A 2VL7A 2O7BA 5F91A 4BAAA 1FUOA 1GK3A 4APBA 4E88A 4YIKA 1FURA 5EYTA 2YV5A 1T6JA 4C5UA 3R6VA 1TJUA 3OCFA 1C3UA 2PTQA 1C3CA 1DOFA 4EFCA 1YISA 1Y2MA 2PTRA 3CRW1 3U13A 3OCEA 5M0JA 5EYVA 5M0IA 1Z4KA 2RJSA 1B8FA 3C8TA 5D6BA 2X75A 4A15A 3F4SA 1FUQA 4FLCA 4BABA 2PTSA 4L57A 4L6AA 1TJWA 2FUSA 4NLEA 4C6GA 1K62A 5H8WA 1DCNA 1JSWA 1YFMA 2J91A 2PFMA 3NZ4A 2O7DA 1VDKA 4MX2A 1XL7A 4HGVA 2I7DA 2QVEA 2JAWA 3CZOA 4C5SA 2O6YA 4V2QA 1AUWA 2E9FA 3E04A
chains in the Genus database with same CATH topology
3NO9A 1XWOA 3UNVA 2VD6A 2YIIA 1I0AA 4EEIA 4ADLA 1U15A 1EB4A 2NYFA 3RRPA 4APAA 2HVGA 1RE5A 1TJVA 4FFXA 5HW2A 1GKJA 2OHYA 3R6YA 3QBPA 1TJ7A 2NYNA 1KQ7A 4C5RA 2O7FA 4V2RA 1J3UA 3RD8A 1W27A 3BHGA 1U16A 4CQ5A 1T6PA 5F92A 1GK2A 3GTDA 3KDYA 1HY1A 3R6QA 4ADMA 4NSLA 2QGAB 2O78A 1FUPA 3GZHA 2RJRA 1K7WA 1Q5NA 1GKMA 1YFEA 3TV2A 3KDZA 2O7EA 1HY0A 2O7BA 5F91A 4BAAA 1FUOA 1GK3A 4APBA 1FURA 5EYTA 1T6JA 4C5UA 3R6VA 1TJUA 3OCFA 1C3UA 2PTQA 1C3CA 1DOFA 4EFCA 1YISA 1Y2MA 2PTRA 3OCEA 5EYVA 2RJSA 1B8FA 3C8TA 5D6BA 2X75A 1FUQA 4FLCA 4BABA 2PTSA 4C6GA 1TJWA 2FUSA 4NLEA 1K62A 1DCNA 1JSWA 1YFMA 2J91A 2PFMA 3NZ4A 2O7DA 1VDKA 4MX2A 4HGVA 2QVEA 3CZOA 4C5SA 2O6YA 4V2QA 1AUWA 2E9FA 3E04A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NO9 A;  1XWO A;  3UNV A;  2VD6 A;  2YII A;  1I0A A;  4EEI A;  4ADL A;  1U15 A;  1EB4 A;  2NYF A;  3RRP A;  4APA A;  2HVG A;  1RE5 A;  1TJV A;  4FFX A;  5HW2 A;  1GKJ A;  2OHY A;  3R6Y A;  3QBP A;  1TJ7 A;  2NYN A;  1KQ7 A;  4C5R A;  2O7F A;  4V2R A;  1J3U A;  3RD8 A;  1W27 A;  3BHG A;  1U16 A;  4CQ5 A;  1T6P A;  5F92 A;  1GK2 A;  3GTD A;  3KDY A;  1HY1 A;  3R6Q A;  4ADM A;  4NSL A;  2QGA B;  2O78 A;  1FUP A;  3GZH A;  2RJR A;  1K7W A;  1Q5N A;  1GKM A;  1YFE A;  3TV2 A;  3KDZ A;  2O7E A;  1HY0 A;  2O7B A;  5F91 A;  4BAA A;  1FUO A;  1GK3 A;  4APB A;  1FUR A;  5EYT A;  1T6J A;  4C5U A;  3R6V A;  1TJU A;  3OCF A;  1C3U A;  2PTQ A;  1C3C A;  1DOF A;  4EFC A;  1YIS A;  1Y2M A;  2PTR A;  3OCE A;  5EYV A;  2RJS A;  1B8F A;  3C8T A;  5D6B A;  2X75 A;  1FUQ A;  4FLC A;  4BAB A;  2PTS A;  4C6G A;  1TJW A;  2FUS A;  4NLE A;  1K62 A;  1DCN A;  1JSW A;  1YFM A;  2J91 A;  2PFM A;  3NZ4 A;  2O7D A;  1VDK A;  4MX2 A;  4HGV A;  2QVE A;  3CZO A;  4C5S A;  2O6Y A;  4V2Q A;  1AUW A;  2E9F A;  3E04 A; 
#chains in the Genus database with same CATH topology
 3NO9 A;  3F4T A;  1XWO A;  1U0L A;  3UNV A;  1Z4Q A;  2D27 A;  2VD6 A;  2YII A;  1I0A A;  4EEI A;  2FEN A;  4ADL A;  1U15 A;  1EB4 A;  2NYF A;  3RRP A;  1XMD A;  4APA A;  2HVG A;  1RE5 A;  1TJV A;  4IQJ M;  1Z4P X;  2FEL A;  1Z4M A;  4FFX A;  5HW2 A;  1GKJ A;  2OHY A;  3R6Y A;  3QBP A;  1TJ7 A;  2NYN A;  2VSF A;  4L6C A;  1KQ7 A;  2JAO A;  4C5R A;  2O7F A;  2JAR A;  4V2R A;  1XLY A;  4WNL A;  1XMC A;  1Z4I A;  4MUM A;  3F4R A;  1IW7 D;  2JAU A;  1J3U A;  1Q92 A;  2RCN A;  3RD8 A;  1MH9 A;  1W27 A;  3BHG A;  4NFL A;  1U16 A;  1Q91 A;  4CQ5 A;  1T9H A;  3U19 A;  1T6P A;  2D28 C;  5F92 A;  1Z4L A;  1GK2 A;  3GTD A;  3KDY A;  4MWO A;  1HY1 A;  3R6Q A;  4ADM A;  4NSL A;  2QGA B;  1FUP A;  3GZH A;  2O78 A;  2RJR A;  1K7W A;  3BWV A;  1Q5N A;  1GKM A;  3CI0 K;  4YIH A;  1YFE A;  3TV2 A;  1XL8 A;  3CRV A;  1Z4J A;  3KDZ A;  2O7E A;  1HY0 A;  2VL7 A;  2O7B A;  5F91 A;  4BAA A;  1FUO A;  1GK3 A;  4APB A;  4E88 A;  4YIK A;  1FUR A;  5EYT A;  2YV5 A;  1T6J A;  4C5U A;  3R6V A;  1TJU A;  3OCF A;  1C3U A;  2PTQ A;  1C3C A;  1DOF A;  4EFC A;  1YIS A;  1Y2M A;  2PTR A;  3CRW 1;  3U13 A;  3OCE A;  5M0J A;  5EYV A;  5M0I A;  1Z4K A;  2RJS A;  1B8F A;  3C8T A;  5D6B A;  2X75 A;  4A15 A;  3F4S A;  1FUQ A;  4FLC A;  4BAB A;  2PTS A;  4L57 A;  4L6A A;  1TJW A;  2FUS A;  4NLE A;  4C6G A;  1K62 A;  5H8W A;  1DCN A;  1JSW A;  1YFM A;  2J91 A;  2PFM A;  3NZ4 A;  2O7D A;  1VDK A;  4MX2 A;  1XL7 A;  4HGV A;  2I7D A;  2QVE A;  2JAW A;  3CZO A;  4C5S A;  2O6Y A;  4V2Q A;  1AUW A;  2E9F A;  3E04 A; 
#chains in the Genus database with same CATH homology
 3NO9 A;  1XWO A;  3UNV A;  2VD6 A;  2YII A;  1I0A A;  4EEI A;  4ADL A;  1U15 A;  1EB4 A;  2NYF A;  3RRP A;  4APA A;  2HVG A;  1RE5 A;  1TJV A;  4FFX A;  5HW2 A;  1GKJ A;  2OHY A;  3R6Y A;  3QBP A;  1TJ7 A;  2NYN A;  1KQ7 A;  4C5R A;  2O7F A;  4V2R A;  1J3U A;  3RD8 A;  1W27 A;  3BHG A;  1U16 A;  4CQ5 A;  1T6P A;  5F92 A;  1GK2 A;  3GTD A;  3KDY A;  1HY1 A;  3R6Q A;  4ADM A;  4NSL A;  2QGA B;  2O78 A;  1FUP A;  3GZH A;  2RJR A;  1K7W A;  1Q5N A;  1GKM A;  1YFE A;  3TV2 A;  3KDZ A;  2O7E A;  1HY0 A;  2O7B A;  5F91 A;  4BAA A;  1FUO A;  1GK3 A;  4APB A;  1FUR A;  5EYT A;  1T6J A;  4C5U A;  3R6V A;  1TJU A;  3OCF A;  1C3U A;  2PTQ A;  1C3C A;  1DOF A;  4EFC A;  1YIS A;  1Y2M A;  2PTR A;  3OCE A;  5EYV A;  2RJS A;  1B8F A;  3C8T A;  5D6B A;  2X75 A;  1FUQ A;  4FLC A;  4BAB A;  2PTS A;  4C6G A;  1TJW A;  2FUS A;  4NLE A;  1K62 A;  1DCN A;  1JSW A;  1YFM A;  2J91 A;  2PFM A;  3NZ4 A;  2O7D A;  1VDK A;  4MX2 A;  4HGV A;  2QVE A;  3CZO A;  4C5S A;  2O6Y A;  4V2Q A;  1AUW A;  2E9F A;  3E04 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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