1FUPA

Fumarase with bound pyromellitic acid
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
sequence length
455
structure length
455
Chain Sequence
RSEKDSMGAIDVPADKLWGAQTQRSLEHFRISTEKMPTSLIHALALTKRAAAKVNEDLGLLSEEKASAIRQAADEVLAGQHDDEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGVRGMERKVHPNDDVNKSQSSNDVFPTAMHVAALLALRKQLIPQLKTLTQTLNEKSRAFADIVKIGRTHLQDATPLTLGQEISGWVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYARRVADELAVITCAPFVTAPNKFEALATCDALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEISIPENEPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHNFLQSVRLLADGMESFNKHCAVGIEPNRERINQLLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAALALGYLSEAEFDSWVRPEQM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords FUMARASE C
publication title Crystallographic studies of the catalytic and a second site in fumarase C from Escherichia coli.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Lyase
total genus 177
structure length 455
sequence length 455
chains with identical sequence B
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 1996-08-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 1fupA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1fupA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1fupA02
3RRPA 1J3UA 3KDZA 1AUWA 3TV2A 3E04A 1C3CA 1YISA 3CZOA 4CQ5A 5EYTA 4C5SA 2PFMA 5F91A 3C8TA 2PTRA 3GTDA 3OCFA 2FUSA 2PTQA 5F92A 1TJWA 4C5RA 4C5UA 2O7BA 2NYFA 4NSLA 1GK3A 1TJ7A 1K62A 2QGAB 3R6VA 3NO9A 2RJSA 4NLEA 4V2RA 1DCNA 1C3UA 2PTSA 5EYVA 1K7WA 1HY1A 1RE5A 1TJVA 3UNVA 2RJRA 2J91A 1U15A 3NZ4A 1YFEA 4APBA 4APAA 2O6YA 1XWOA 4C6GA 2O7EA 3RD8A 1EB4A 1T6PA 1U16A 1VDKA 1TJUA 1HY0A 1W27A 2VD6A 4FFXA 2NYNA 1GKJA 1FUPA 3GZHA 4BAAA 5D6BA 4FLCA 1GKMA 4ADMA 4HGVA 4EFCA 3OCEA 1B8FA 3BHGA 1Y2MA 4ADLA 1YFMA 1KQ7A 4EEIA 1FUQA 2O7DA 3KDYA 4MX2A 4V2QA 2QVEA 4BABA 2YIIA 3R6QA 1Q5NA 3R6YA 5HW2A 1FURA 2OHYA 2E9FA 3QBPA 2X75A 1DOFA 1FUOA 1GK2A 1JSWA 1I0AA 1T6JA 2O78A 2HVGA 2O7FA
chains in the Genus database with same CATH superfamily
3RRPA 2RCNA 1J3UA 4L6CA 3KDZA 1AUWA 1MH9A 1Q92A 3TV2A 3E04A 1C3CA 3U19A 1YISA 3CZOA 4L57A 5M0JA 1IW7D 4CQ5A 5EYTA 4C5SA 2PFMA 5F91A 3C8TA 1XLYA 1Z4JA 2PTRA 3GTDA 3OCFA 2FUSA 2PTQA 5F92A 1TJWA 4IQJM 4C5RA 2FELA 4C5UA 2JAOA 2D27A 2NYFA 2O7BA 1Z4KA 4NSLA 1GK3A 1TJ7A 5M0IA 1K62A 4L6AA 2QGAB 3R6VA 3CI0K 3NO9A 2RJSA 4WNLA 4NLEA 4V2RA 1DCNA 1C3UA 2PTSA 5EYVA 1K7WA 1HY1A 1RE5A 1TJVA 3UNVA 2RJRA 2J91A 1U15A 3NZ4A 4MWOA 1YFEA 3CRVA 4YIKA 4APBA 2JARA 3U13A 4APAA 2O6YA 1XWOA 4C6GA 1T9HA 2O7EA 3RD8A 2YV5A 1EB4A 2VSFA 1T6PA 1U16A 1VDKA 1TJUA 1HY0A 1Z4QA 1W27A 1XMCA 2NYNA 4YIHA 2VD6A 4FFXA 1GKJA 1FUPA 3GZHA 4BAAA 5D6BA 2JAUA 1Z4PX 3CRW1 4MUMA 4FLCA 1GKMA 3F4RA 4ADMA 4HGVA 1XMDA 4EFCA 2VL7A 3OCEA 1B8FA 3BHGA 1Y2MA 1XL8A 1Z4IA 4ADLA 1XL7A 4NFLA 1YFMA 1KQ7A 4E88A 4EEIA 5H8WA 1FUQA 2O7DA 3F4SA 3KDYA 1Z4MA 1U0LA 4MX2A 4V2QA 2FENA 3BWVA 2QVEA 4BABA 2YIIA 3R6QA 4A15A 2JAWA 1Q5NA 3F4TA 3R6YA 2I7DA 5HW2A 1FURA 2OHYA 2E9FA 3QBPA 2X75A 2D28C 1DOFA 1FUOA 1Q91A 1JSWA 1I0AA 1Z4LA 1GK2A 2HVGA 1T6JA 2O78A 2O7FA
chains in the Genus database with same CATH topology
3RRPA 1J3UA 3KDZA 1AUWA 3TV2A 3E04A 1C3CA 1YISA 3CZOA 4CQ5A 5EYTA 4C5SA 2PFMA 5F91A 3C8TA 2PTRA 3GTDA 3OCFA 2FUSA 2PTQA 5F92A 1TJWA 4C5RA 4C5UA 2O7BA 2NYFA 4NSLA 1GK3A 1TJ7A 1K62A 2QGAB 3R6VA 3NO9A 2RJSA 4NLEA 4V2RA 1DCNA 1C3UA 2PTSA 5EYVA 1K7WA 1HY1A 1RE5A 1TJVA 3UNVA 2RJRA 2J91A 1U15A 3NZ4A 1YFEA 4APBA 4APAA 2O6YA 1XWOA 4C6GA 2O7EA 3RD8A 1EB4A 1T6PA 1U16A 1VDKA 1TJUA 1HY0A 1W27A 2VD6A 4FFXA 2NYNA 1GKJA 1FUPA 3GZHA 4BAAA 5D6BA 4FLCA 1GKMA 4ADMA 4HGVA 4EFCA 3OCEA 1B8FA 3BHGA 1Y2MA 4ADLA 1YFMA 1KQ7A 4EEIA 1FUQA 2O7DA 3KDYA 4MX2A 4V2QA 2QVEA 4BABA 2YIIA 3R6QA 1Q5NA 3R6YA 5HW2A 1FURA 2OHYA 2E9FA 3QBPA 2X75A 1DOFA 1FUOA 1GK2A 1JSWA 1I0AA 1T6JA 2O78A 2HVGA 2O7FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3RRP A;  1J3U A;  3KDZ A;  1AUW A;  3TV2 A;  3E04 A;  1C3C A;  1YIS A;  3CZO A;  4CQ5 A;  5EYT A;  4C5S A;  2PFM A;  5F91 A;  3C8T A;  2PTR A;  3GTD A;  3OCF A;  2FUS A;  2PTQ A;  5F92 A;  1TJW A;  4C5R A;  4C5U A;  2O7B A;  2NYF A;  4NSL A;  1GK3 A;  1TJ7 A;  1K62 A;  2QGA B;  3R6V A;  3NO9 A;  2RJS A;  4NLE A;  4V2R A;  1DCN A;  1C3U A;  2PTS A;  5EYV A;  1K7W A;  1HY1 A;  1RE5 A;  1TJV A;  3UNV A;  2RJR A;  2J91 A;  1U15 A;  3NZ4 A;  1YFE A;  4APB A;  4APA A;  2O6Y A;  1XWO A;  4C6G A;  2O7E A;  3RD8 A;  1EB4 A;  1T6P A;  1U16 A;  1VDK A;  1TJU A;  1HY0 A;  1W27 A;  2VD6 A;  4FFX A;  2NYN A;  1GKJ A;  1FUP A;  3GZH A;  4BAA A;  5D6B A;  4FLC A;  1GKM A;  4ADM A;  4HGV A;  4EFC A;  3OCE A;  1B8F A;  3BHG A;  1Y2M A;  4ADL A;  1YFM A;  1KQ7 A;  4EEI A;  1FUQ A;  2O7D A;  3KDY A;  4MX2 A;  4V2Q A;  2QVE A;  4BAB A;  2YII A;  3R6Q A;  1Q5N A;  3R6Y A;  5HW2 A;  1FUR A;  2OHY A;  2E9F A;  3QBP A;  2X75 A;  1DOF A;  1FUO A;  1GK2 A;  1JSW A;  1I0A A;  1T6J A;  2O78 A;  2HVG A;  2O7F A; 
#chains in the Genus database with same CATH topology
 3RRP A;  2RCN A;  1J3U A;  4L6C A;  3KDZ A;  1AUW A;  1MH9 A;  1Q92 A;  3TV2 A;  3E04 A;  1C3C A;  3U19 A;  1YIS A;  3CZO A;  4L57 A;  5M0J A;  1IW7 D;  4CQ5 A;  5EYT A;  4C5S A;  2PFM A;  5F91 A;  3C8T A;  1XLY A;  1Z4J A;  2PTR A;  3GTD A;  3OCF A;  2FUS A;  2PTQ A;  5F92 A;  1TJW A;  4IQJ M;  4C5R A;  2FEL A;  4C5U A;  2JAO A;  2D27 A;  2NYF A;  2O7B A;  1Z4K A;  4NSL A;  1GK3 A;  1TJ7 A;  5M0I A;  1K62 A;  4L6A A;  2QGA B;  3R6V A;  3CI0 K;  3NO9 A;  2RJS A;  4WNL A;  4NLE A;  4V2R A;  1DCN A;  1C3U A;  2PTS A;  5EYV A;  1K7W A;  1HY1 A;  1RE5 A;  1TJV A;  3UNV A;  2RJR A;  2J91 A;  1U15 A;  3NZ4 A;  4MWO A;  1YFE A;  3CRV A;  4YIK A;  4APB A;  2JAR A;  3U13 A;  4APA A;  2O6Y A;  1XWO A;  4C6G A;  1T9H A;  2O7E A;  3RD8 A;  2YV5 A;  1EB4 A;  2VSF A;  1T6P A;  1U16 A;  1VDK A;  1TJU A;  1HY0 A;  1Z4Q A;  1W27 A;  1XMC A;  2NYN A;  4YIH A;  2VD6 A;  4FFX A;  1GKJ A;  1FUP A;  3GZH A;  4BAA A;  5D6B A;  2JAU A;  1Z4P X;  3CRW 1;  4MUM A;  4FLC A;  1GKM A;  3F4R A;  4ADM A;  4HGV A;  1XMD A;  4EFC A;  2VL7 A;  3OCE A;  1B8F A;  3BHG A;  1Y2M A;  1XL8 A;  1Z4I A;  4ADL A;  1XL7 A;  4NFL A;  1YFM A;  1KQ7 A;  4E88 A;  4EEI A;  5H8W A;  1FUQ A;  2O7D A;  3F4S A;  3KDY A;  1Z4M A;  1U0L A;  4MX2 A;  4V2Q A;  2FEN A;  3BWV A;  2QVE A;  4BAB A;  2YII A;  3R6Q A;  4A15 A;  2JAW A;  1Q5N A;  3F4T A;  3R6Y A;  2I7D A;  5HW2 A;  1FUR A;  2OHY A;  2E9F A;  3QBP A;  2X75 A;  2D28 C;  1DOF A;  1FUO A;  1Q91 A;  1JSW A;  1I0A A;  1Z4L A;  1GK2 A;  2HVG A;  1T6J A;  2O78 A;  2O7F A; 
#chains in the Genus database with same CATH homology
 3RRP A;  1J3U A;  3KDZ A;  1AUW A;  3TV2 A;  3E04 A;  1C3C A;  1YIS A;  3CZO A;  4CQ5 A;  5EYT A;  4C5S A;  2PFM A;  5F91 A;  3C8T A;  2PTR A;  3GTD A;  3OCF A;  2FUS A;  2PTQ A;  5F92 A;  1TJW A;  4C5R A;  4C5U A;  2O7B A;  2NYF A;  4NSL A;  1GK3 A;  1TJ7 A;  1K62 A;  2QGA B;  3R6V A;  3NO9 A;  2RJS A;  4NLE A;  4V2R A;  1DCN A;  1C3U A;  2PTS A;  5EYV A;  1K7W A;  1HY1 A;  1RE5 A;  1TJV A;  3UNV A;  2RJR A;  2J91 A;  1U15 A;  3NZ4 A;  1YFE A;  4APB A;  4APA A;  2O6Y A;  1XWO A;  4C6G A;  2O7E A;  3RD8 A;  1EB4 A;  1T6P A;  1U16 A;  1VDK A;  1TJU A;  1HY0 A;  1W27 A;  2VD6 A;  4FFX A;  2NYN A;  1GKJ A;  1FUP A;  3GZH A;  4BAA A;  5D6B A;  4FLC A;  1GKM A;  4ADM A;  4HGV A;  4EFC A;  3OCE A;  1B8F A;  3BHG A;  1Y2M A;  4ADL A;  1YFM A;  1KQ7 A;  4EEI A;  1FUQ A;  2O7D A;  3KDY A;  4MX2 A;  4V2Q A;  2QVE A;  4BAB A;  2YII A;  3R6Q A;  1Q5N A;  3R6Y A;  5HW2 A;  1FUR A;  2OHY A;  2E9F A;  3QBP A;  2X75 A;  1DOF A;  1FUO A;  1GK2 A;  1JSW A;  1I0A A;  1T6J A;  2O78 A;  2HVG A;  2O7F A; 
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similar chains in the pdb database (?% sequence similarity)

 
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