2G7IA

Structure of human complement factor h carboxyl terminal domains 19-20: a basis for atypical hemolytic uremic syndrome
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
124
structure length
124
Chain Sequence
GKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Complement factor H
total genus 22
structure length 124
sequence length 124
ec nomenclature
pdb deposition date 2006-02-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2g7iA01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2g7iA02
4PZ5A 1PPQA 1HFHA 4LOTA 3KZJA 1H2QP 2EHFA 2O39C 2RLQA 1G4GA 3OP8A 4WJG2 2XWJI 3NFPI 1OJWA 1ELVA 4AYIA 4FXGG 4IGDA 1QUBA 3IU3I 2V8EA 2A55A 1OK1A 5HZPB 2MCYA 2XQWC 1G4FA 3SW0X 3T5OA 1VVDA 2ERJA 1HFIA 2KMSA 2CG6A 1TPMA 1CKLA 4C16A 1Q3XA 3ZD2A 1E8BA 2RL0A 2W81A 4AYDA 1GPZA 1LY2A 2B5ID 4MUCA 2JGXA 1MD7A 3ZRZA 1GKNA 4AYMA 2RKZA 2W80A 1O9AA 2BZMA 1E88A 1NWVA 5HYTB 2WIIC 4B2SA 3ZD1A 4K12A 4AYEA 1E5GA 2XRBA 2XWBF 3L89M 1QO6A 1C1ZA 5I0QB 2IZ3A 3KXVA 2JRAA 2XRDA 2RLPA 1GHQB 1H2PP 1MD8A 1QGBA 2YBYA 3IX0A 4ZH1D 4A5WB 1H04P 3OXUD 1OJYA 4LOSA 1UOTP 5FO8C 1OK3A 1HCCA 4ONTD 1VVCA 4B2RA 4J38B 1ZJKA 2YRAA 3INBC 2KRIA 1FBRA 2RKYA 3O8EB 1SRZA 1OK2A 2QY0A 3TVJA 2G7IA 3ERBA 1Z92B 4JHSA 1OK9A 2CG7A 3EJHA 1SS2A 1TPNA 1U5MA 5HYUB 2EC3A 3GOVA 1OJVA 2CKUA 3OEDC 3GXEA 3M7PA 3RJ3D 2LOJA 2UWNA 1GKGA 4KKDA 2IZ4A 1TPGA 2MCZA 3MQLA 4F4OC 3R62A 5HYPA 2JGWA 4CSYA 4DJZA 4YNXA 5JPMG 3CALA 1H03P
chains in the Genus database with same CATH superfamily
4PZ5A 1PPQA 1HFHA 4LOTA 3ZLEA 3KZJA 1H2QP 2EHFA 2O39C 2RLQA 1G4GA 3OP8A 4WJG2 2XWJI 3NFPI 1OJWA 1ELVA 4AYIA 4FXGG 4IGDA 1QUBA 3IU3I 2V8EA 2A55A 1OK1A 5HZPB 2MCYA 2XQWC 1G4FA 3SW0X 3F6KA 3T5OA 1VVDA 2ERJA 1HFIA 2KMSA 2CG6A 1TPMA 2Y8SA 1CKLA 4C16A 1Q3XA 3ZD2A 1E8BA 4APLA 2RL0A 2W81A 4AYDA 1GPZA 3FGRA 1LY2A 2B5ID 4MUCA 2JGXA 1MD7A 4MSLA 5DN5A 3ZRZA 1GKNA 4AYMA 2RKZA 2W80A 1O9AA 2BZMA 2I2LA 4YIZA 1E88A 1NWVA 3CI0J 5HYTB 2WIIC 4B2SA 3ZD1A 1RLHA 4K12A 4AYEA 1E5GA 2XRBA 2XWBF 2X2ZA 2Y8TA 3L89M 1QO6A 1C1ZA 5I0QB 2IZ3A 3KXVA 2JRAA 2XRDA 2RLPA 1GHQB 1H2PP 1MD8A 1QGBA 2YBYA 3IX0A 4ZH1D 4A5WB 1H04P 3OXUD 1OJYA 4LOSA 1UOTP 5FO8C 1OK3A 1HCCA 4ONTD 1VVCA 4B2RA 4J38B 1ZJKA 2YRAA 3INBC 2KRIA 1FBRA 2RKYA 3O8EB 2ZYCA 1SRZA 1OK2A 3ZLDA 3VWOA 3NJAA 5DN4A 2QY0A 3TVJA 3K3TA 4PO7A 3WSXA 2G7IA 3ERBA 1Z92B 4JHSA 1OK9A 4N7EA 2CG7A 3EJHA 1SS2A 2Y8RA 1TPNA 1U5MA 4BWCA 2EC3A 3GOVA 5HYUB 1OJVA 2CKUA 3OEDC 3GXEA 3M7PA 3RJ3D 2LOJA 2UWNA 1GKGA 3WSYA 4KKDA 2IZ4A 1TPGA 2MCZA 3MQLA 4F4OC 3R62A 5HYPA 2JGWA 4CSYA 4DJZA 4YNXA 5JPMG 3FGTA 3CALA 1H03P
chains in the Genus database with same CATH topology
4PZ5A 1PPQA 1HFHA 4LOTA 3KZJA 1H2QP 2EHFA 2O39C 2RLQA 1G4GA 3OP8A 4WJG2 2XWJI 3NFPI 1OJWA 1ELVA 4AYIA 4FXGG 4IGDA 1QUBA 3IU3I 2V8EA 2A55A 1OK1A 5HZPB 2MCYA 2XQWC 1G4FA 3SW0X 3T5OA 1VVDA 2ERJA 1HFIA 2KMSA 2CG6A 1TPMA 1CKLA 4C16A 1Q3XA 3ZD2A 1E8BA 2RL0A 2W81A 4AYDA 1GPZA 1LY2A 2B5ID 4MUCA 2JGXA 1MD7A 3ZRZA 1GKNA 4AYMA 2RKZA 2W80A 1O9AA 2BZMA 1E88A 1NWVA 5HYTB 2WIIC 4B2SA 3ZD1A 4K12A 4AYEA 1E5GA 2XRBA 2XWBF 3L89M 1QO6A 1C1ZA 5I0QB 2IZ3A 3KXVA 2JRAA 2XRDA 2RLPA 1GHQB 1H2PP 1MD8A 1QGBA 2YBYA 3IX0A 4ZH1D 4A5WB 1H04P 3OXUD 1OJYA 4LOSA 1UOTP 5FO8C 1OK3A 1HCCA 4ONTD 1VVCA 4B2RA 4J38B 1ZJKA 2YRAA 3INBC 2KRIA 1FBRA 2RKYA 3O8EB 1SRZA 1OK2A 2QY0A 3TVJA 2G7IA 3ERBA 1Z92B 4JHSA 1OK9A 2CG7A 3EJHA 1SS2A 1TPNA 1U5MA 5HYUB 2EC3A 3GOVA 1OJVA 2CKUA 3OEDC 3GXEA 3M7PA 3RJ3D 2LOJA 2UWNA 1GKGA 4KKDA 2IZ4A 1TPGA 2MCZA 3MQLA 4F4OC 3R62A 5HYPA 2JGWA 4CSYA 4DJZA 4YNXA 5JPMG 3CALA 1H03P
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4PZ5 A;  1PPQ A;  1HFH A;  4LOT A;  3KZJ A;  1H2Q P;  2EHF A;  2O39 C;  2RLQ A;  1G4G A;  3OP8 A;  4WJG 2;  2XWJ I;  3NFP I;  1OJW A;  1ELV A;  4AYI A;  4FXG G;  4IGD A;  1QUB A;  3IU3 I;  2V8E A;  2A55 A;  1OK1 A;  5HZP B;  2MCY A;  2XQW C;  1G4F A;  3SW0 X;  3T5O A;  1VVD A;  2ERJ A;  1HFI A;  2KMS A;  2CG6 A;  1TPM A;  1CKL A;  4C16 A;  1Q3X A;  3ZD2 A;  1E8B A;  2RL0 A;  2W81 A;  4AYD A;  1GPZ A;  1LY2 A;  2B5I D;  4MUC A;  2JGX A;  1MD7 A;  3ZRZ A;  1GKN A;  4AYM A;  2RKZ A;  2W80 A;  1O9A A;  2BZM A;  1E88 A;  1NWV A;  5HYT B;  2WII C;  4B2S A;  3ZD1 A;  4K12 A;  4AYE A;  1E5G A;  2XRB A;  2XWB F;  3L89 M;  1QO6 A;  1C1Z A;  5I0Q B;  2IZ3 A;  3KXV A;  2JRA A;  2XRD A;  2RLP A;  1GHQ B;  1H2P P;  1MD8 A;  1QGB A;  2YBY A;  3IX0 A;  4ZH1 D;  4A5W B;  1H04 P;  3OXU D;  1OJY A;  4LOS A;  1UOT P;  5FO8 C;  1OK3 A;  1HCC A;  4ONT D;  1VVC A;  4B2R A;  4J38 B;  1ZJK A;  2YRA A;  3INB C;  2KRI A;  1FBR A;  2RKY A;  3O8E B;  1SRZ A;  1OK2 A;  2QY0 A;  3TVJ A;  2G7I A;  3ERB A;  1Z92 B;  4JHS A;  1OK9 A;  2CG7 A;  3EJH A;  1SS2 A;  1TPN A;  1U5M A;  5HYU B;  2EC3 A;  3GOV A;  1OJV A;  2CKU A;  3OED C;  3GXE A;  3M7P A;  3RJ3 D;  2LOJ A;  2UWN A;  1GKG A;  4KKD A;  2IZ4 A;  1TPG A;  2MCZ A;  3MQL A;  4F4O C;  3R62 A;  5HYP A;  2JGW A;  4CSY A;  4DJZ A;  4YNX A;  5JPM G;  3CAL A;  1H03 P; 
#chains in the Genus database with same CATH topology
 4PZ5 A;  1PPQ A;  1HFH A;  4LOT A;  3ZLE A;  3KZJ A;  1H2Q P;  2EHF A;  2O39 C;  2RLQ A;  1G4G A;  3OP8 A;  4WJG 2;  2XWJ I;  3NFP I;  1OJW A;  1ELV A;  4AYI A;  4FXG G;  4IGD A;  1QUB A;  3IU3 I;  2V8E A;  2A55 A;  1OK1 A;  5HZP B;  2MCY A;  2XQW C;  1G4F A;  3SW0 X;  3F6K A;  3T5O A;  1VVD A;  2ERJ A;  1HFI A;  2KMS A;  2CG6 A;  1TPM A;  2Y8S A;  1CKL A;  4C16 A;  1Q3X A;  3ZD2 A;  1E8B A;  4APL A;  2RL0 A;  2W81 A;  4AYD A;  1GPZ A;  3FGR A;  1LY2 A;  2B5I D;  4MUC A;  2JGX A;  1MD7 A;  4MSL A;  5DN5 A;  3ZRZ A;  1GKN A;  4AYM A;  2RKZ A;  2W80 A;  1O9A A;  2BZM A;  2I2L A;  4YIZ A;  1E88 A;  1NWV A;  3CI0 J;  5HYT B;  2WII C;  4B2S A;  3ZD1 A;  1RLH A;  4K12 A;  4AYE A;  1E5G A;  2XRB A;  2XWB F;  2X2Z A;  2Y8T A;  3L89 M;  1QO6 A;  1C1Z A;  5I0Q B;  2IZ3 A;  3KXV A;  2JRA A;  2XRD A;  2RLP A;  1GHQ B;  1H2P P;  1MD8 A;  1QGB A;  2YBY A;  3IX0 A;  4ZH1 D;  4A5W B;  1H04 P;  3OXU D;  1OJY A;  4LOS A;  1UOT P;  5FO8 C;  1OK3 A;  1HCC A;  4ONT D;  1VVC A;  4B2R A;  4J38 B;  1ZJK A;  2YRA A;  3INB C;  2KRI A;  1FBR A;  2RKY A;  3O8E B;  2ZYC A;  1SRZ A;  1OK2 A;  3ZLD A;  3VWO A;  3NJA A;  5DN4 A;  2QY0 A;  3TVJ A;  3K3T A;  4PO7 A;  3WSX A;  2G7I A;  3ERB A;  1Z92 B;  4JHS A;  1OK9 A;  4N7E A;  2CG7 A;  3EJH A;  1SS2 A;  2Y8R A;  1TPN A;  1U5M A;  4BWC A;  2EC3 A;  3GOV A;  5HYU B;  1OJV A;  2CKU A;  3OED C;  3GXE A;  3M7P A;  3RJ3 D;  2LOJ A;  2UWN A;  1GKG A;  3WSY A;  4KKD A;  2IZ4 A;  1TPG A;  2MCZ A;  3MQL A;  4F4O C;  3R62 A;  5HYP A;  2JGW A;  4CSY A;  4DJZ A;  4YNX A;  5JPM G;  3FGT A;  3CAL A;  1H03 P; 
#chains in the Genus database with same CATH homology
 4PZ5 A;  1PPQ A;  1HFH A;  4LOT A;  3KZJ A;  1H2Q P;  2EHF A;  2O39 C;  2RLQ A;  1G4G A;  3OP8 A;  4WJG 2;  2XWJ I;  3NFP I;  1OJW A;  1ELV A;  4AYI A;  4FXG G;  4IGD A;  1QUB A;  3IU3 I;  2V8E A;  2A55 A;  1OK1 A;  5HZP B;  2MCY A;  2XQW C;  1G4F A;  3SW0 X;  3T5O A;  1VVD A;  2ERJ A;  1HFI A;  2KMS A;  2CG6 A;  1TPM A;  1CKL A;  4C16 A;  1Q3X A;  3ZD2 A;  1E8B A;  2RL0 A;  2W81 A;  4AYD A;  1GPZ A;  1LY2 A;  2B5I D;  4MUC A;  2JGX A;  1MD7 A;  3ZRZ A;  1GKN A;  4AYM A;  2RKZ A;  2W80 A;  1O9A A;  2BZM A;  1E88 A;  1NWV A;  5HYT B;  2WII C;  4B2S A;  3ZD1 A;  4K12 A;  4AYE A;  1E5G A;  2XRB A;  2XWB F;  3L89 M;  1QO6 A;  1C1Z A;  5I0Q B;  2IZ3 A;  3KXV A;  2JRA A;  2XRD A;  2RLP A;  1GHQ B;  1H2P P;  1MD8 A;  1QGB A;  2YBY A;  3IX0 A;  4ZH1 D;  4A5W B;  1H04 P;  3OXU D;  1OJY A;  4LOS A;  1UOT P;  5FO8 C;  1OK3 A;  1HCC A;  4ONT D;  1VVC A;  4B2R A;  4J38 B;  1ZJK A;  2YRA A;  3INB C;  2KRI A;  1FBR A;  2RKY A;  3O8E B;  1SRZ A;  1OK2 A;  2QY0 A;  3TVJ A;  2G7I A;  3ERB A;  1Z92 B;  4JHS A;  1OK9 A;  2CG7 A;  3EJH A;  1SS2 A;  1TPN A;  1U5M A;  5HYU B;  2EC3 A;  3GOV A;  1OJV A;  2CKU A;  3OED C;  3GXE A;  3M7P A;  3RJ3 D;  2LOJ A;  2UWN A;  1GKG A;  4KKD A;  2IZ4 A;  1TPG A;  2MCZ A;  3MQL A;  4F4O C;  3R62 A;  5HYP A;  2JGW A;  4CSY A;  4DJZ A;  4YNX A;  5JPM G;  3CAL A;  1H03 P; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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