2G7IA

Structure of human complement factor h carboxyl terminal domains 19-20: a basis for atypical hemolytic uremic syndrome
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
124
structure length
124
Chain Sequence
GKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Complement factor H
total genus 22
structure length 124
sequence length 124
ec nomenclature
pdb deposition date 2006-02-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2g7iA01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2g7iA02
4F4OC 1HCCA 2JGXA 1OK1A 1C1ZA 3MQLA 1HFIA 2XRBA 2UWNA 2RKZA 3OP8A 3ZRZA 2CKUA 1UOTP 3KZJA 3NFPI 3T5OA 1OJWA 3GXEA 2LOJA 3KXVA 5HZPB 2KMSA 2O39C 5FO8C 1MD7A 2EHFA 3M7PA 3L89M 3ZD1A 2QY0A 4PZ5A 3ZD2A 1TPGA 4K12A 2RKYA 1LY2A 4B2RA 3R62A 4ZH1D 4WJG2 1SRZA 2B5ID 2RLPA 3OXUD 1E88A 3CALA 1VVCA 4B2SA 2G7IA 1OJYA 3INBC 1O9AA 1Q3XA 1H2PP 2V8EA 2EC3A 1U5MA 2KRIA 1GKNA 1H04P 2IZ3A 4A5WB 4KKDA 5I0QB 4JHSA 2YBYA 1HFHA 2BZMA 3OEDC 2A55A 1OJVA 4CSYA 2YRAA 4MUCA 5HYUB 1CKLA 2MCYA 1PPQA 2W80A 3TVJA 4FXGG 4DJZA 2MCZA 2XWBF 4C16A 4IGDA 2RL0A 4J38B 1H03P 2W81A 3IU3I 3RJ3D 2CG6A 2CG7A 3O8EB 1G4GA 1OK2A 4YNXA 4AYIA 1SS2A 1QUBA 1TPMA 3EJHA 4ONTD 5JPMG 1MD8A 3IX0A 4LOTA 1FBRA 2XWJI 1GKGA 1E8BA 1OK3A 4AYDA 2XQWC 1G4FA 2XRDA 4AYEA 1QO6A 1TPNA 3GOVA 2WIIC 5HYPA 2RLQA 1E5GA 3ERBA 1QGBA 1GHQB 4AYMA 5HYTB 1H2QP 1ZJKA 1ELVA 3SW0X 1Z92B 2ERJA 2IZ4A 4LOSA 1GPZA 1NWVA 2JGWA 1OK9A 1VVDA 2JRAA
chains in the Genus database with same CATH superfamily
4F4OC 1HCCA 2JGXA 1OK1A 1C1ZA 3MQLA 1HFIA 2XRBA 2UWNA 2RKZA 3OP8A 3ZRZA 2CKUA 1UOTP 3KZJA 3NFPI 3T5OA 1OJWA 3GXEA 4MSLA 2LOJA 1RLHA 3KXVA 5HZPB 2KMSA 3CI0J 3FGTA 2O39C 3WSYA 5FO8C 1MD7A 2EHFA 3F6KA 3M7PA 3L89M 3ZD1A 2QY0A 4PZ5A 3ZD2A 1TPGA 4K12A 2RKYA 1LY2A 4B2RA 3R62A 4ZH1D 4WJG2 1SRZA 2B5ID 2RLPA 3OXUD 1E88A 3CALA 5DN4A 1VVCA 4B2SA 2G7IA 1OJYA 3INBC 1O9AA 1Q3XA 1H2PP 2V8EA 2EC3A 1U5MA 2KRIA 1GKNA 1H04P 5DN5A 2IZ3A 3VWOA 4A5WB 4KKDA 5I0QB 4JHSA 2YBYA 1HFHA 2BZMA 3OEDC 2A55A 1OJVA 2Y8SA 4CSYA 2YRAA 4MUCA 5HYUB 1CKLA 4BWCA 2MCYA 1PPQA 2W80A 3NJAA 4YIZA 3TVJA 3ZLDA 4FXGG 2I2LA 4PO7A 4DJZA 2MCZA 2XWBF 4C16A 4IGDA 4N7EA 2RL0A 3WSXA 2Y8RA 4J38B 1H03P 2W81A 3ZLEA 3IU3I 3RJ3D 2CG6A 2CG7A 3O8EB 1G4GA 1OK2A 4YNXA 4AYIA 1SS2A 4APLA 1QUBA 1TPMA 3EJHA 4ONTD 5JPMG 1MD8A 3IX0A 4LOTA 1FBRA 2XWJI 3K3TA 1GKGA 3FGRA 2Y8TA 1E8BA 1OK3A 4AYDA 2XQWC 1G4FA 2XRDA 4AYEA 1QO6A 1TPNA 3GOVA 2WIIC 5HYPA 2RLQA 1E5GA 3ERBA 1QGBA 1GHQB 4AYMA 5HYTB 1H2QP 1ZJKA 1ELVA 3SW0X 1Z92B 2ZYCA 2ERJA 2IZ4A 4LOSA 1GPZA 1NWVA 2JGWA 1OK9A 1VVDA 2X2ZA 2JRAA
chains in the Genus database with same CATH topology
4F4OC 1HCCA 2JGXA 1OK1A 1C1ZA 3MQLA 1HFIA 2XRBA 2UWNA 2RKZA 3OP8A 3ZRZA 2CKUA 1UOTP 3KZJA 3NFPI 3T5OA 1OJWA 3GXEA 2LOJA 3KXVA 5HZPB 2KMSA 2O39C 5FO8C 1MD7A 2EHFA 3M7PA 3L89M 3ZD1A 2QY0A 4PZ5A 3ZD2A 1TPGA 4K12A 2RKYA 1LY2A 4B2RA 3R62A 4ZH1D 4WJG2 1SRZA 2B5ID 2RLPA 3OXUD 1E88A 3CALA 1VVCA 4B2SA 2G7IA 1OJYA 3INBC 1O9AA 1Q3XA 1H2PP 2V8EA 2EC3A 1U5MA 2KRIA 1GKNA 1H04P 2IZ3A 4A5WB 4KKDA 5I0QB 4JHSA 2YBYA 1HFHA 2BZMA 3OEDC 2A55A 1OJVA 4CSYA 2YRAA 4MUCA 5HYUB 1CKLA 2MCYA 1PPQA 2W80A 3TVJA 4FXGG 4DJZA 2MCZA 2XWBF 4C16A 4IGDA 2RL0A 4J38B 1H03P 2W81A 3IU3I 3RJ3D 2CG6A 2CG7A 3O8EB 1G4GA 1OK2A 4YNXA 4AYIA 1SS2A 1QUBA 1TPMA 3EJHA 4ONTD 5JPMG 1MD8A 3IX0A 4LOTA 1FBRA 2XWJI 1GKGA 1E8BA 1OK3A 4AYDA 2XQWC 1G4FA 2XRDA 4AYEA 1QO6A 1TPNA 3GOVA 2WIIC 5HYPA 2RLQA 1E5GA 3ERBA 1QGBA 1GHQB 4AYMA 5HYTB 1H2QP 1ZJKA 1ELVA 3SW0X 1Z92B 2ERJA 2IZ4A 4LOSA 1GPZA 1NWVA 2JGWA 1OK9A 1VVDA 2JRAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4F4O C;  1HCC A;  2JGX A;  1OK1 A;  1C1Z A;  3MQL A;  1HFI A;  2XRB A;  2UWN A;  2RKZ A;  3OP8 A;  3ZRZ A;  2CKU A;  1UOT P;  3KZJ A;  3NFP I;  3T5O A;  1OJW A;  3GXE A;  2LOJ A;  3KXV A;  5HZP B;  2KMS A;  2O39 C;  5FO8 C;  1MD7 A;  2EHF A;  3M7P A;  3L89 M;  3ZD1 A;  2QY0 A;  4PZ5 A;  3ZD2 A;  1TPG A;  4K12 A;  2RKY A;  1LY2 A;  4B2R A;  3R62 A;  4ZH1 D;  4WJG 2;  1SRZ A;  2B5I D;  2RLP A;  3OXU D;  1E88 A;  3CAL A;  1VVC A;  4B2S A;  2G7I A;  1OJY A;  3INB C;  1O9A A;  1Q3X A;  1H2P P;  2V8E A;  2EC3 A;  1U5M A;  2KRI A;  1GKN A;  1H04 P;  2IZ3 A;  4A5W B;  4KKD A;  5I0Q B;  4JHS A;  2YBY A;  1HFH A;  2BZM A;  3OED C;  2A55 A;  1OJV A;  4CSY A;  2YRA A;  4MUC A;  5HYU B;  1CKL A;  2MCY A;  1PPQ A;  2W80 A;  3TVJ A;  4FXG G;  4DJZ A;  2MCZ A;  2XWB F;  4C16 A;  4IGD A;  2RL0 A;  4J38 B;  1H03 P;  2W81 A;  3IU3 I;  3RJ3 D;  2CG6 A;  2CG7 A;  3O8E B;  1G4G A;  1OK2 A;  4YNX A;  4AYI A;  1SS2 A;  1QUB A;  1TPM A;  3EJH A;  4ONT D;  5JPM G;  1MD8 A;  3IX0 A;  4LOT A;  1FBR A;  2XWJ I;  1GKG A;  1E8B A;  1OK3 A;  4AYD A;  2XQW C;  1G4F A;  2XRD A;  4AYE A;  1QO6 A;  1TPN A;  3GOV A;  2WII C;  5HYP A;  2RLQ A;  1E5G A;  3ERB A;  1QGB A;  1GHQ B;  4AYM A;  5HYT B;  1H2Q P;  1ZJK A;  1ELV A;  3SW0 X;  1Z92 B;  2ERJ A;  2IZ4 A;  4LOS A;  1GPZ A;  1NWV A;  2JGW A;  1OK9 A;  1VVD A;  2JRA A; 
#chains in the Genus database with same CATH topology
 4F4O C;  1HCC A;  2JGX A;  1OK1 A;  1C1Z A;  3MQL A;  1HFI A;  2XRB A;  2UWN A;  2RKZ A;  3OP8 A;  3ZRZ A;  2CKU A;  1UOT P;  3KZJ A;  3NFP I;  3T5O A;  1OJW A;  3GXE A;  4MSL A;  2LOJ A;  1RLH A;  3KXV A;  5HZP B;  2KMS A;  3CI0 J;  3FGT A;  2O39 C;  3WSY A;  5FO8 C;  1MD7 A;  2EHF A;  3F6K A;  3M7P A;  3L89 M;  3ZD1 A;  2QY0 A;  4PZ5 A;  3ZD2 A;  1TPG A;  4K12 A;  2RKY A;  1LY2 A;  4B2R A;  3R62 A;  4ZH1 D;  4WJG 2;  1SRZ A;  2B5I D;  2RLP A;  3OXU D;  1E88 A;  3CAL A;  5DN4 A;  1VVC A;  4B2S A;  2G7I A;  1OJY A;  3INB C;  1O9A A;  1Q3X A;  1H2P P;  2V8E A;  2EC3 A;  1U5M A;  2KRI A;  1GKN A;  1H04 P;  5DN5 A;  2IZ3 A;  3VWO A;  4A5W B;  4KKD A;  5I0Q B;  4JHS A;  2YBY A;  1HFH A;  2BZM A;  3OED C;  2A55 A;  1OJV A;  2Y8S A;  4CSY A;  2YRA A;  4MUC A;  5HYU B;  1CKL A;  4BWC A;  2MCY A;  1PPQ A;  2W80 A;  3NJA A;  4YIZ A;  3TVJ A;  3ZLD A;  4FXG G;  2I2L A;  4PO7 A;  4DJZ A;  2MCZ A;  2XWB F;  4C16 A;  4IGD A;  4N7E A;  2RL0 A;  3WSX A;  2Y8R A;  4J38 B;  1H03 P;  2W81 A;  3ZLE A;  3IU3 I;  3RJ3 D;  2CG6 A;  2CG7 A;  3O8E B;  1G4G A;  1OK2 A;  4YNX A;  4AYI A;  1SS2 A;  4APL A;  1QUB A;  1TPM A;  3EJH A;  4ONT D;  5JPM G;  1MD8 A;  3IX0 A;  4LOT A;  1FBR A;  2XWJ I;  3K3T A;  1GKG A;  3FGR A;  2Y8T A;  1E8B A;  1OK3 A;  4AYD A;  2XQW C;  1G4F A;  2XRD A;  4AYE A;  1QO6 A;  1TPN A;  3GOV A;  2WII C;  5HYP A;  2RLQ A;  1E5G A;  3ERB A;  1QGB A;  1GHQ B;  4AYM A;  5HYT B;  1H2Q P;  1ZJK A;  1ELV A;  3SW0 X;  1Z92 B;  2ZYC A;  2ERJ A;  2IZ4 A;  4LOS A;  1GPZ A;  1NWV A;  2JGW A;  1OK9 A;  1VVD A;  2X2Z A;  2JRA A; 
#chains in the Genus database with same CATH homology
 4F4O C;  1HCC A;  2JGX A;  1OK1 A;  1C1Z A;  3MQL A;  1HFI A;  2XRB A;  2UWN A;  2RKZ A;  3OP8 A;  3ZRZ A;  2CKU A;  1UOT P;  3KZJ A;  3NFP I;  3T5O A;  1OJW A;  3GXE A;  2LOJ A;  3KXV A;  5HZP B;  2KMS A;  2O39 C;  5FO8 C;  1MD7 A;  2EHF A;  3M7P A;  3L89 M;  3ZD1 A;  2QY0 A;  4PZ5 A;  3ZD2 A;  1TPG A;  4K12 A;  2RKY A;  1LY2 A;  4B2R A;  3R62 A;  4ZH1 D;  4WJG 2;  1SRZ A;  2B5I D;  2RLP A;  3OXU D;  1E88 A;  3CAL A;  1VVC A;  4B2S A;  2G7I A;  1OJY A;  3INB C;  1O9A A;  1Q3X A;  1H2P P;  2V8E A;  2EC3 A;  1U5M A;  2KRI A;  1GKN A;  1H04 P;  2IZ3 A;  4A5W B;  4KKD A;  5I0Q B;  4JHS A;  2YBY A;  1HFH A;  2BZM A;  3OED C;  2A55 A;  1OJV A;  4CSY A;  2YRA A;  4MUC A;  5HYU B;  1CKL A;  2MCY A;  1PPQ A;  2W80 A;  3TVJ A;  4FXG G;  4DJZ A;  2MCZ A;  2XWB F;  4C16 A;  4IGD A;  2RL0 A;  4J38 B;  1H03 P;  2W81 A;  3IU3 I;  3RJ3 D;  2CG6 A;  2CG7 A;  3O8E B;  1G4G A;  1OK2 A;  4YNX A;  4AYI A;  1SS2 A;  1QUB A;  1TPM A;  3EJH A;  4ONT D;  5JPM G;  1MD8 A;  3IX0 A;  4LOT A;  1FBR A;  2XWJ I;  1GKG A;  1E8B A;  1OK3 A;  4AYD A;  2XQW C;  1G4F A;  2XRD A;  4AYE A;  1QO6 A;  1TPN A;  3GOV A;  2WII C;  5HYP A;  2RLQ A;  1E5G A;  3ERB A;  1QGB A;  1GHQ B;  4AYM A;  5HYT B;  1H2Q P;  1ZJK A;  1ELV A;  3SW0 X;  1Z92 B;  2ERJ A;  2IZ4 A;  4LOS A;  1GPZ A;  1NWV A;  2JGW A;  1OK9 A;  1VVD A;  2JRA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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