2RLPA

Nmr structure of ccp modules 1-2 of complement factor h
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
123
structure length
123
Chain Sequence
DCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords Complement factor H
total genus 22
structure length 123
sequence length 123
ec nomenclature
pdb deposition date 2007-07-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2rlpA02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 2rlpA01
2JRAA 2QY0A 5HZPB 1VVCA 1E88A 2XRDA 1Z92B 2XQWC 4FXGG 1E5GA 1PPQA 4LOTA 3CALA 3GXEA 4YNXA 2CKUA 3EJHA 3IU3I 1H2QP 2JGWA 1OJVA 4AYDA 3KXVA 1ZJKA 2YRAA 1U5MA 1CKLA 4F4OC 2RKZA 3L89M 1HCCA 4ONTD 4C16A 2KRIA 3GOVA 1TPGA 4J38B 3R62A 2IZ4A 2JGXA 2A55A 1TPMA 2W81A 3ZD1A 2UWNA 2CG7A 4A5WB 2B5ID 3T5OA 5FO8C 4WJG2 1MD7A 4B2RA 5JPMG 2O39C 3ERBA 1SRZA 2CG6A 2EC3A 2XWJI 4DJZA 2RLQA 1QGBA 4ZH1D 2G7IA 1GHQB 4LOSA 1LY2A 4B2SA 4KKDA 1OK3A 3NFPI 1TPNA 2WIIC 1HFHA 1GPZA 2LOJA 1FBRA 4AYMA 4CSYA 1QO6A 3M7PA 5HYUB 1C1ZA 1OK2A 1OK1A 3OP8A 5HYPA 4AYEA 3SW0X 4PZ5A 1OJWA 3MQLA 1Q3XA 3O8EB 3ZD2A 1UOTP 1HFIA 1O9AA 3OEDC 1H03P 2V8EA 1H04P 2EHFA 2XWBF 3KZJA 2KMSA 3ZRZA 2RLPA 4AYIA 1OJYA 5I0QB 1NWVA 2BZMA 1SS2A 1VVDA 1GKGA 2ERJA 5HYTB 2W80A 1ELVA 2YBYA 1MD8A 1H2PP 2RL0A 4IGDA 1E8BA 4MUCA 2XRBA 3IX0A 2MCYA 3OXUD 1QUBA 3TVJA 2RKYA 1G4GA 2IZ3A 2MCZA 1G4FA 4JHSA 4K12A 3RJ3D 1OK9A 1GKNA 3INBC
chains in the Genus database with same CATH superfamily
2JRAA 2QY0A 5HZPB 1VVCA 1E88A 2XRDA 1Z92B 2XQWC 4FXGG 1E5GA 1PPQA 4LOTA 3CALA 3GXEA 4YNXA 2CKUA 3EJHA 3IU3I 1H2QP 2JGWA 1OJVA 3VWOA 4AYDA 3KXVA 1ZJKA 2YRAA 1U5MA 4PO7A 1CKLA 3FGTA 4F4OC 2RKZA 2Y8RA 3L89M 3NJAA 3F6KA 1HCCA 4ONTD 4C16A 2KRIA 3GOVA 1TPGA 4J38B 4MSLA 3R62A 2IZ4A 2JGXA 2A55A 1TPMA 2W81A 3ZD1A 2UWNA 2CG7A 4A5WB 2B5ID 3T5OA 5FO8C 4YIZA 4WJG2 1MD7A 4B2RA 5JPMG 2O39C 3ERBA 1SRZA 2CG6A 2EC3A 2XWJI 4DJZA 2RLQA 1QGBA 2X2ZA 4ZH1D 2G7IA 1GHQB 4LOSA 1LY2A 4B2SA 4KKDA 1OK3A 3NFPI 1TPNA 2WIIC 5DN4A 1HFHA 1GPZA 2LOJA 1FBRA 4AYMA 4CSYA 1QO6A 3M7PA 5HYUB 2ZYCA 1C1ZA 1OK2A 1OK1A 3OP8A 4N7EA 5HYPA 4AYEA 3SW0X 4PZ5A 3WSYA 1OJWA 3MQLA 1Q3XA 3O8EB 3WSXA 3ZD2A 1UOTP 1HFIA 2Y8TA 1O9AA 3OEDC 1H03P 2V8EA 3ZLDA 1H04P 2EHFA 2XWBF 3KZJA 1RLHA 2KMSA 5DN5A 2RLPA 3ZRZA 1OJYA 4AYIA 5I0QB 1NWVA 2BZMA 1SS2A 1VVDA 4APLA 2ERJA 1GKGA 5HYTB 2W80A 1ELVA 2YBYA 1MD8A 3CI0J 1H2PP 2RL0A 4IGDA 1E8BA 4MUCA 2XRBA 3IX0A 3K3TA 2MCYA 3OXUD 1QUBA 3TVJA 2RKYA 1G4GA 4BWCA 2IZ3A 2I2LA 2MCZA 1G4FA 4JHSA 4K12A 3FGRA 2Y8SA 3ZLEA 3RJ3D 1OK9A 1GKNA 3INBC
chains in the Genus database with same CATH topology
2JRAA 2QY0A 5HZPB 1VVCA 1E88A 2XRDA 1Z92B 2XQWC 4FXGG 1E5GA 1PPQA 4LOTA 3CALA 3GXEA 4YNXA 2CKUA 3EJHA 3IU3I 1H2QP 2JGWA 1OJVA 4AYDA 3KXVA 1ZJKA 2YRAA 1U5MA 1CKLA 4F4OC 2RKZA 3L89M 1HCCA 4ONTD 4C16A 2KRIA 3GOVA 1TPGA 4J38B 3R62A 2IZ4A 2JGXA 2A55A 1TPMA 2W81A 3ZD1A 2UWNA 2CG7A 4A5WB 2B5ID 3T5OA 5FO8C 4WJG2 1MD7A 4B2RA 5JPMG 2O39C 3ERBA 1SRZA 2CG6A 2EC3A 2XWJI 4DJZA 2RLQA 1QGBA 4ZH1D 2G7IA 1GHQB 4LOSA 1LY2A 4B2SA 4KKDA 1OK3A 3NFPI 1TPNA 2WIIC 1HFHA 1GPZA 2LOJA 1FBRA 4AYMA 4CSYA 1QO6A 3M7PA 5HYUB 1C1ZA 1OK2A 1OK1A 3OP8A 5HYPA 4AYEA 3SW0X 4PZ5A 1OJWA 3MQLA 1Q3XA 3O8EB 3ZD2A 1UOTP 1HFIA 1O9AA 3OEDC 1H03P 2V8EA 1H04P 2EHFA 2XWBF 3KZJA 2KMSA 3ZRZA 2RLPA 4AYIA 1OJYA 5I0QB 1NWVA 2BZMA 1SS2A 1VVDA 1GKGA 2ERJA 5HYTB 2W80A 1ELVA 2YBYA 1MD8A 1H2PP 2RL0A 4IGDA 1E8BA 4MUCA 2XRBA 3IX0A 2MCYA 3OXUD 1QUBA 3TVJA 2RKYA 1G4GA 2IZ3A 2MCZA 1G4FA 4JHSA 4K12A 3RJ3D 1OK9A 1GKNA 3INBC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JRA A;  2QY0 A;  5HZP B;  1VVC A;  1E88 A;  2XRD A;  1Z92 B;  2XQW C;  4FXG G;  1E5G A;  1PPQ A;  4LOT A;  3CAL A;  3GXE A;  4YNX A;  2CKU A;  3EJH A;  3IU3 I;  1H2Q P;  2JGW A;  1OJV A;  4AYD A;  3KXV A;  1ZJK A;  2YRA A;  1U5M A;  1CKL A;  4F4O C;  2RKZ A;  3L89 M;  1HCC A;  4ONT D;  4C16 A;  2KRI A;  3GOV A;  1TPG A;  4J38 B;  3R62 A;  2IZ4 A;  2JGX A;  2A55 A;  1TPM A;  2W81 A;  3ZD1 A;  2UWN A;  2CG7 A;  4A5W B;  2B5I D;  3T5O A;  5FO8 C;  4WJG 2;  1MD7 A;  4B2R A;  5JPM G;  2O39 C;  3ERB A;  1SRZ A;  2CG6 A;  2EC3 A;  2XWJ I;  4DJZ A;  2RLQ A;  1QGB A;  4ZH1 D;  2G7I A;  1GHQ B;  4LOS A;  1LY2 A;  4B2S A;  4KKD A;  1OK3 A;  3NFP I;  1TPN A;  2WII C;  1HFH A;  1GPZ A;  2LOJ A;  1FBR A;  4AYM A;  4CSY A;  1QO6 A;  3M7P A;  5HYU B;  1C1Z A;  1OK2 A;  1OK1 A;  3OP8 A;  5HYP A;  4AYE A;  3SW0 X;  4PZ5 A;  1OJW A;  3MQL A;  1Q3X A;  3O8E B;  3ZD2 A;  1UOT P;  1HFI A;  1O9A A;  3OED C;  1H03 P;  2V8E A;  1H04 P;  2EHF A;  2XWB F;  3KZJ A;  2KMS A;  3ZRZ A;  2RLP A;  4AYI A;  1OJY A;  5I0Q B;  1NWV A;  2BZM A;  1SS2 A;  1VVD A;  1GKG A;  2ERJ A;  5HYT B;  2W80 A;  1ELV A;  2YBY A;  1MD8 A;  1H2P P;  2RL0 A;  4IGD A;  1E8B A;  4MUC A;  2XRB A;  3IX0 A;  2MCY A;  3OXU D;  1QUB A;  3TVJ A;  2RKY A;  1G4G A;  2IZ3 A;  2MCZ A;  1G4F A;  4JHS A;  4K12 A;  3RJ3 D;  1OK9 A;  1GKN A;  3INB C; 
#chains in the Genus database with same CATH topology
 2JRA A;  2QY0 A;  5HZP B;  1VVC A;  1E88 A;  2XRD A;  1Z92 B;  2XQW C;  4FXG G;  1E5G A;  1PPQ A;  4LOT A;  3CAL A;  3GXE A;  4YNX A;  2CKU A;  3EJH A;  3IU3 I;  1H2Q P;  2JGW A;  1OJV A;  3VWO A;  4AYD A;  3KXV A;  1ZJK A;  2YRA A;  1U5M A;  4PO7 A;  1CKL A;  3FGT A;  4F4O C;  2RKZ A;  2Y8R A;  3L89 M;  3NJA A;  3F6K A;  1HCC A;  4ONT D;  4C16 A;  2KRI A;  3GOV A;  1TPG A;  4J38 B;  4MSL A;  3R62 A;  2IZ4 A;  2JGX A;  2A55 A;  1TPM A;  2W81 A;  3ZD1 A;  2UWN A;  2CG7 A;  4A5W B;  2B5I D;  3T5O A;  5FO8 C;  4YIZ A;  4WJG 2;  1MD7 A;  4B2R A;  5JPM G;  2O39 C;  3ERB A;  1SRZ A;  2CG6 A;  2EC3 A;  2XWJ I;  4DJZ A;  2RLQ A;  1QGB A;  2X2Z A;  4ZH1 D;  2G7I A;  1GHQ B;  4LOS A;  1LY2 A;  4B2S A;  4KKD A;  1OK3 A;  3NFP I;  1TPN A;  2WII C;  5DN4 A;  1HFH A;  1GPZ A;  2LOJ A;  1FBR A;  4AYM A;  4CSY A;  1QO6 A;  3M7P A;  5HYU B;  2ZYC A;  1C1Z A;  1OK2 A;  1OK1 A;  3OP8 A;  4N7E A;  5HYP A;  4AYE A;  3SW0 X;  4PZ5 A;  3WSY A;  1OJW A;  3MQL A;  1Q3X A;  3O8E B;  3WSX A;  3ZD2 A;  1UOT P;  1HFI A;  2Y8T A;  1O9A A;  3OED C;  1H03 P;  2V8E A;  3ZLD A;  1H04 P;  2EHF A;  2XWB F;  3KZJ A;  1RLH A;  2KMS A;  5DN5 A;  2RLP A;  3ZRZ A;  1OJY A;  4AYI A;  5I0Q B;  1NWV A;  2BZM A;  1SS2 A;  1VVD A;  4APL A;  2ERJ A;  1GKG A;  5HYT B;  2W80 A;  1ELV A;  2YBY A;  1MD8 A;  3CI0 J;  1H2P P;  2RL0 A;  4IGD A;  1E8B A;  4MUC A;  2XRB A;  3IX0 A;  3K3T A;  2MCY A;  3OXU D;  1QUB A;  3TVJ A;  2RKY A;  1G4G A;  4BWC A;  2IZ3 A;  2I2L A;  2MCZ A;  1G4F A;  4JHS A;  4K12 A;  3FGR A;  2Y8S A;  3ZLE A;  3RJ3 D;  1OK9 A;  1GKN A;  3INB C; 
#chains in the Genus database with same CATH homology
 2JRA A;  2QY0 A;  5HZP B;  1VVC A;  1E88 A;  2XRD A;  1Z92 B;  2XQW C;  4FXG G;  1E5G A;  1PPQ A;  4LOT A;  3CAL A;  3GXE A;  4YNX A;  2CKU A;  3EJH A;  3IU3 I;  1H2Q P;  2JGW A;  1OJV A;  4AYD A;  3KXV A;  1ZJK A;  2YRA A;  1U5M A;  1CKL A;  4F4O C;  2RKZ A;  3L89 M;  1HCC A;  4ONT D;  4C16 A;  2KRI A;  3GOV A;  1TPG A;  4J38 B;  3R62 A;  2IZ4 A;  2JGX A;  2A55 A;  1TPM A;  2W81 A;  3ZD1 A;  2UWN A;  2CG7 A;  4A5W B;  2B5I D;  3T5O A;  5FO8 C;  4WJG 2;  1MD7 A;  4B2R A;  5JPM G;  2O39 C;  3ERB A;  1SRZ A;  2CG6 A;  2EC3 A;  2XWJ I;  4DJZ A;  2RLQ A;  1QGB A;  4ZH1 D;  2G7I A;  1GHQ B;  4LOS A;  1LY2 A;  4B2S A;  4KKD A;  1OK3 A;  3NFP I;  1TPN A;  2WII C;  1HFH A;  1GPZ A;  2LOJ A;  1FBR A;  4AYM A;  4CSY A;  1QO6 A;  3M7P A;  5HYU B;  1C1Z A;  1OK2 A;  1OK1 A;  3OP8 A;  5HYP A;  4AYE A;  3SW0 X;  4PZ5 A;  1OJW A;  3MQL A;  1Q3X A;  3O8E B;  3ZD2 A;  1UOT P;  1HFI A;  1O9A A;  3OED C;  1H03 P;  2V8E A;  1H04 P;  2EHF A;  2XWB F;  3KZJ A;  2KMS A;  3ZRZ A;  2RLP A;  4AYI A;  1OJY A;  5I0Q B;  1NWV A;  2BZM A;  1SS2 A;  1VVD A;  1GKG A;  2ERJ A;  5HYT B;  2W80 A;  1ELV A;  2YBY A;  1MD8 A;  1H2P P;  2RL0 A;  4IGD A;  1E8B A;  4MUC A;  2XRB A;  3IX0 A;  2MCY A;  3OXU D;  1QUB A;  3TVJ A;  2RKY A;  1G4G A;  2IZ3 A;  2MCZ A;  1G4F A;  4JHS A;  4K12 A;  3RJ3 D;  1OK9 A;  1GKN A;  3INB C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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