4B2SA

Solution structure of ccp modules 11-12 of complement factor h
Total Genus 16
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
16
sequence length
127
structure length
127
Chain Sequence
EAEAAGVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLPVCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQLPQCVAI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Solution Structure of Ccp Modules 10-12 Illuminates Functional Architecture of the Complement Regulator, Factor H.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords COMPLEMENT FACTOR H
total genus 16
structure length 127
sequence length 127
ec nomenclature
pdb deposition date 2012-07-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4b2sA02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4b2sA01
1HFIA 2XRBA 1QUBA 2UWNA 3EJHA 3OEDC 4F4OC 2LOJA 2MCZA 3OP8A 2JGWA 4AYEA 1LY2A 1TPMA 1O9AA 2RL0A 4AYMA 1H04P 1G4FA 3KXVA 1GKGA 1VVDA 1GHQB 1Z92B 1Q3XA 1HFHA 4K12A 3O8EB 1E5GA 4LOTA 1MD8A 1OK3A 2A55A 4B2SA 1OJWA 3NFPI 2W81A 4IGDA 3CALA 1OK9A 2EC3A 3T5OA 2QY0A 2JRAA 1NWVA 4A5WB 4FXGG 1VVCA 4JHSA 1PPQA 4PZ5A 4LOSA 3ZRZA 3KZJA 3RJ3D 1ZJKA 2W80A 3GOVA 2XWJI 3OXUD 2KMSA 4KKDA 4MUCA 2BZMA 1H03P 2RLPA 2B5ID 3ERBA 1HCCA 1SS2A 3SW0X 1TPNA 5HZPB 2CG7A 4DJZA 1OJVA 3MQLA 5JPMG 2EHFA 3ZD2A 2XWBF 1ELVA 2RKYA 2CKUA 1CKLA 1E88A 4WJG2 3M7PA 1C1ZA 2YBYA 5HYTB 3ZD1A 1QGBA 1FBRA 2RLQA 2IZ3A 1G4GA 1SRZA 1OJYA 4B2RA 1OK1A 2G7IA 1MD7A 1OK2A 4J38B 4ONTD 1E8BA 4AYIA 2XQWC 5HYPA 4YNXA 1QO6A 2JGXA 4C16A 1H2QP 1GKNA 5FO8C 2V8EA 2RKZA 3IU3I 3L89M 2IZ4A 1UOTP 2CG6A 2KRIA 3GXEA 1TPGA 2WIIC 2YRAA 3R62A 1H2PP 4ZH1D 2XRDA 4AYDA 1U5MA 3INBC 5HYUB 2ERJA 3IX0A 1GPZA 4CSYA 3TVJA 2MCYA 2O39C 5I0QB
chains in the Genus database with same CATH superfamily
1HFIA 2XRBA 1QUBA 2UWNA 3EJHA 3OEDC 3K3TA 4F4OC 2LOJA 2MCZA 3OP8A 2JGWA 4AYEA 4PO7A 1LY2A 1TPMA 1O9AA 2RL0A 3WSXA 4AYMA 1H04P 4BWCA 1G4FA 3KXVA 1GKGA 1VVDA 1GHQB 1Z92B 1Q3XA 1HFHA 4K12A 3O8EB 1E5GA 4LOTA 1MD8A 2ZYCA 4N7EA 1OK3A 2A55A 4B2SA 1OJWA 3NFPI 2W81A 4APLA 4IGDA 3CALA 1OK9A 1RLHA 2EC3A 3T5OA 2QY0A 2JRAA 1NWVA 4A5WB 4FXGG 1VVCA 4JHSA 1PPQA 4PZ5A 4LOSA 3ZRZA 3KZJA 3RJ3D 1ZJKA 2W80A 3GOVA 2XWJI 3OXUD 2KMSA 4KKDA 4MUCA 2BZMA 1H03P 2RLPA 2B5ID 3F6KA 4MSLA 3ERBA 1HCCA 1SS2A 3SW0X 1TPNA 5HZPB 2CG7A 4DJZA 1OJVA 3MQLA 5JPMG 5DN5A 2EHFA 3ZD2A 2XWBF 1ELVA 2RKYA 2CKUA 1CKLA 4YIZA 5DN4A 1E88A 4WJG2 3M7PA 1C1ZA 2I2LA 2YBYA 3ZLEA 2Y8SA 2Y8TA 5HYTB 3ZD1A 1QGBA 1FBRA 3WSYA 2RLQA 2IZ3A 1G4GA 1SRZA 1OJYA 4B2RA 1OK1A 2G7IA 3NJAA 1MD7A 1OK2A 4J38B 4ONTD 1E8BA 4AYIA 2XQWC 3FGTA 5HYPA 4YNXA 2X2ZA 1QO6A 2JGXA 4C16A 1H2QP 1GKNA 2Y8RA 5FO8C 2V8EA 2RKZA 3IU3I 3L89M 2IZ4A 1UOTP 2CG6A 2KRIA 3GXEA 1TPGA 2WIIC 2YRAA 3R62A 3ZLDA 1H2PP 4ZH1D 2XRDA 4AYDA 1U5MA 3INBC 5HYUB 3VWOA 2ERJA 3IX0A 1GPZA 3FGRA 3TVJA 4CSYA 2MCYA 3CI0J 2O39C 5I0QB
chains in the Genus database with same CATH topology
1HFIA 2XRBA 1QUBA 2UWNA 3EJHA 3OEDC 4F4OC 2LOJA 2MCZA 3OP8A 2JGWA 4AYEA 1LY2A 1TPMA 1O9AA 2RL0A 4AYMA 1H04P 1G4FA 3KXVA 1GKGA 1VVDA 1GHQB 1Z92B 1Q3XA 1HFHA 4K12A 3O8EB 1E5GA 4LOTA 1MD8A 1OK3A 2A55A 4B2SA 1OJWA 3NFPI 2W81A 4IGDA 3CALA 1OK9A 2EC3A 3T5OA 2QY0A 2JRAA 1NWVA 4A5WB 4FXGG 1VVCA 4JHSA 1PPQA 4PZ5A 4LOSA 3ZRZA 3KZJA 3RJ3D 1ZJKA 2W80A 3GOVA 2XWJI 3OXUD 2KMSA 4KKDA 4MUCA 2BZMA 1H03P 2RLPA 2B5ID 3ERBA 1HCCA 1SS2A 3SW0X 1TPNA 5HZPB 2CG7A 4DJZA 1OJVA 3MQLA 5JPMG 2EHFA 3ZD2A 2XWBF 1ELVA 2RKYA 2CKUA 1CKLA 1E88A 4WJG2 3M7PA 1C1ZA 2YBYA 5HYTB 3ZD1A 1QGBA 1FBRA 2RLQA 2IZ3A 1G4GA 1SRZA 1OJYA 4B2RA 1OK1A 2G7IA 1MD7A 1OK2A 4J38B 4ONTD 1E8BA 4AYIA 2XQWC 5HYPA 4YNXA 1QO6A 2JGXA 4C16A 1H2QP 1GKNA 5FO8C 2V8EA 2RKZA 3IU3I 3L89M 2IZ4A 1UOTP 2CG6A 2KRIA 3GXEA 1TPGA 2WIIC 2YRAA 3R62A 1H2PP 4ZH1D 2XRDA 4AYDA 1U5MA 3INBC 5HYUB 2ERJA 3IX0A 1GPZA 4CSYA 3TVJA 2MCYA 2O39C 5I0QB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HFI A;  2XRB A;  1QUB A;  2UWN A;  3EJH A;  3OED C;  4F4O C;  2LOJ A;  2MCZ A;  3OP8 A;  2JGW A;  4AYE A;  1LY2 A;  1TPM A;  1O9A A;  2RL0 A;  4AYM A;  1H04 P;  1G4F A;  3KXV A;  1GKG A;  1VVD A;  1GHQ B;  1Z92 B;  1Q3X A;  1HFH A;  4K12 A;  3O8E B;  1E5G A;  4LOT A;  1MD8 A;  1OK3 A;  2A55 A;  4B2S A;  1OJW A;  3NFP I;  2W81 A;  4IGD A;  3CAL A;  1OK9 A;  2EC3 A;  3T5O A;  2QY0 A;  2JRA A;  1NWV A;  4A5W B;  4FXG G;  1VVC A;  4JHS A;  1PPQ A;  4PZ5 A;  4LOS A;  3ZRZ A;  3KZJ A;  3RJ3 D;  1ZJK A;  2W80 A;  3GOV A;  2XWJ I;  3OXU D;  2KMS A;  4KKD A;  4MUC A;  2BZM A;  1H03 P;  2RLP A;  2B5I D;  3ERB A;  1HCC A;  1SS2 A;  3SW0 X;  1TPN A;  5HZP B;  2CG7 A;  4DJZ A;  1OJV A;  3MQL A;  5JPM G;  2EHF A;  3ZD2 A;  2XWB F;  1ELV A;  2RKY A;  2CKU A;  1CKL A;  1E88 A;  4WJG 2;  3M7P A;  1C1Z A;  2YBY A;  5HYT B;  3ZD1 A;  1QGB A;  1FBR A;  2RLQ A;  2IZ3 A;  1G4G A;  1SRZ A;  1OJY A;  4B2R A;  1OK1 A;  2G7I A;  1MD7 A;  1OK2 A;  4J38 B;  4ONT D;  1E8B A;  4AYI A;  2XQW C;  5HYP A;  4YNX A;  1QO6 A;  2JGX A;  4C16 A;  1H2Q P;  1GKN A;  5FO8 C;  2V8E A;  2RKZ A;  3IU3 I;  3L89 M;  2IZ4 A;  1UOT P;  2CG6 A;  2KRI A;  3GXE A;  1TPG A;  2WII C;  2YRA A;  3R62 A;  1H2P P;  4ZH1 D;  2XRD A;  4AYD A;  1U5M A;  3INB C;  5HYU B;  2ERJ A;  3IX0 A;  1GPZ A;  4CSY A;  3TVJ A;  2MCY A;  2O39 C;  5I0Q B; 
#chains in the Genus database with same CATH topology
 1HFI A;  2XRB A;  1QUB A;  2UWN A;  3EJH A;  3OED C;  3K3T A;  4F4O C;  2LOJ A;  2MCZ A;  3OP8 A;  2JGW A;  4AYE A;  4PO7 A;  1LY2 A;  1TPM A;  1O9A A;  2RL0 A;  3WSX A;  4AYM A;  1H04 P;  4BWC A;  1G4F A;  3KXV A;  1GKG A;  1VVD A;  1GHQ B;  1Z92 B;  1Q3X A;  1HFH A;  4K12 A;  3O8E B;  1E5G A;  4LOT A;  1MD8 A;  2ZYC A;  4N7E A;  1OK3 A;  2A55 A;  4B2S A;  1OJW A;  3NFP I;  2W81 A;  4APL A;  4IGD A;  3CAL A;  1OK9 A;  1RLH A;  2EC3 A;  3T5O A;  2QY0 A;  2JRA A;  1NWV A;  4A5W B;  4FXG G;  1VVC A;  4JHS A;  1PPQ A;  4PZ5 A;  4LOS A;  3ZRZ A;  3KZJ A;  3RJ3 D;  1ZJK A;  2W80 A;  3GOV A;  2XWJ I;  3OXU D;  2KMS A;  4KKD A;  4MUC A;  2BZM A;  1H03 P;  2RLP A;  2B5I D;  3F6K A;  4MSL A;  3ERB A;  1HCC A;  1SS2 A;  3SW0 X;  1TPN A;  5HZP B;  2CG7 A;  4DJZ A;  1OJV A;  3MQL A;  5JPM G;  5DN5 A;  2EHF A;  3ZD2 A;  2XWB F;  1ELV A;  2RKY A;  2CKU A;  1CKL A;  4YIZ A;  5DN4 A;  1E88 A;  4WJG 2;  3M7P A;  1C1Z A;  2I2L A;  2YBY A;  3ZLE A;  2Y8S A;  2Y8T A;  5HYT B;  3ZD1 A;  1QGB A;  1FBR A;  3WSY A;  2RLQ A;  2IZ3 A;  1G4G A;  1SRZ A;  1OJY A;  4B2R A;  1OK1 A;  2G7I A;  3NJA A;  1MD7 A;  1OK2 A;  4J38 B;  4ONT D;  1E8B A;  4AYI A;  2XQW C;  3FGT A;  5HYP A;  4YNX A;  2X2Z A;  1QO6 A;  2JGX A;  4C16 A;  1H2Q P;  1GKN A;  2Y8R A;  5FO8 C;  2V8E A;  2RKZ A;  3IU3 I;  3L89 M;  2IZ4 A;  1UOT P;  2CG6 A;  2KRI A;  3GXE A;  1TPG A;  2WII C;  2YRA A;  3R62 A;  3ZLD A;  1H2P P;  4ZH1 D;  2XRD A;  4AYD A;  1U5M A;  3INB C;  5HYU B;  3VWO A;  2ERJ A;  3IX0 A;  1GPZ A;  3FGR A;  3TVJ A;  4CSY A;  2MCY A;  3CI0 J;  2O39 C;  5I0Q B; 
#chains in the Genus database with same CATH homology
 1HFI A;  2XRB A;  1QUB A;  2UWN A;  3EJH A;  3OED C;  4F4O C;  2LOJ A;  2MCZ A;  3OP8 A;  2JGW A;  4AYE A;  1LY2 A;  1TPM A;  1O9A A;  2RL0 A;  4AYM A;  1H04 P;  1G4F A;  3KXV A;  1GKG A;  1VVD A;  1GHQ B;  1Z92 B;  1Q3X A;  1HFH A;  4K12 A;  3O8E B;  1E5G A;  4LOT A;  1MD8 A;  1OK3 A;  2A55 A;  4B2S A;  1OJW A;  3NFP I;  2W81 A;  4IGD A;  3CAL A;  1OK9 A;  2EC3 A;  3T5O A;  2QY0 A;  2JRA A;  1NWV A;  4A5W B;  4FXG G;  1VVC A;  4JHS A;  1PPQ A;  4PZ5 A;  4LOS A;  3ZRZ A;  3KZJ A;  3RJ3 D;  1ZJK A;  2W80 A;  3GOV A;  2XWJ I;  3OXU D;  2KMS A;  4KKD A;  4MUC A;  2BZM A;  1H03 P;  2RLP A;  2B5I D;  3ERB A;  1HCC A;  1SS2 A;  3SW0 X;  1TPN A;  5HZP B;  2CG7 A;  4DJZ A;  1OJV A;  3MQL A;  5JPM G;  2EHF A;  3ZD2 A;  2XWB F;  1ELV A;  2RKY A;  2CKU A;  1CKL A;  1E88 A;  4WJG 2;  3M7P A;  1C1Z A;  2YBY A;  5HYT B;  3ZD1 A;  1QGB A;  1FBR A;  2RLQ A;  2IZ3 A;  1G4G A;  1SRZ A;  1OJY A;  4B2R A;  1OK1 A;  2G7I A;  1MD7 A;  1OK2 A;  4J38 B;  4ONT D;  1E8B A;  4AYI A;  2XQW C;  5HYP A;  4YNX A;  1QO6 A;  2JGX A;  4C16 A;  1H2Q P;  1GKN A;  5FO8 C;  2V8E A;  2RKZ A;  3IU3 I;  3L89 M;  2IZ4 A;  1UOT P;  2CG6 A;  2KRI A;  3GXE A;  1TPG A;  2WII C;  2YRA A;  3R62 A;  1H2P P;  4ZH1 D;  2XRD A;  4AYD A;  1U5M A;  3INB C;  5HYU B;  2ERJ A;  3IX0 A;  1GPZ A;  4CSY A;  3TVJ A;  2MCY A;  2O39 C;  5I0Q B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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