3WSYA

Sorla vps10p domain in complex with its own propeptide fragment
Total Genus 144
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
144
sequence length
668
structure length
662
Chain Sequence
QPEPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFADAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHLLGSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQVFVCVSHSNNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMETNELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHSWLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGPPVPCPSTYRRTRGYRKISGDTCSGGDVEARLEGELVPCP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for amyloidogenic peptide recognition by sorLA
doi rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords Sortilin-related receptor
total genus 144
structure length 662
sequence length 668
ec nomenclature
pdb deposition date 2014-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF15901 Sortilin_C Sortilin, neurotensin receptor 3, C-terminal
A PF15902 Sortilin-Vps10 Sortilin, neurotensin receptor 3,
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.90 Mainly Beta Ribbon Complement Module; domain 1 Complement Module; domain 1 3wsyA03
3WSYA 3F6KA 4MSLA 4PO7A 3WSXA 4N7EA
chains in the Genus database with same CATH superfamily
2I2LA 2XQWC 3F6KA 1OJVA 2RLQA 4IGDA 2JRAA 1QGBA 4LOTA 1E88A 4B2RA 1E5GA 4JHSA 4WJG2 1G4FA 1G4GA 1H03P 5DN4A 1E8BA 1TPMA 2B5ID 4KKDA 3KZJA 1TPGA 2WIIC 1LY2A 1Q3XA 1UOTP 2YBYA 4LOSA 1NWVA 4PO7A 2BZMA 2Y8SA 4AYIA 1MD8A 2MCYA 3GXEA 1GKNA 1SRZA 3NFPI 2JGXA 2W81A 2KRIA 3ZD2A 4AYMA 3NJAA 4J38B 2CKUA 3FGTA 5JPMG 1GKGA 3IU3I 4ZH1D 4FXGG 1HCCA 5HZPB 3SW0X 2IZ3A 1O9AA 1VVDA 2Y8RA 4K12A 2XWJI 1TPNA 4C16A 2RKZA 2RLPA 1FBRA 1ELVA 1OK9A 3K3TA 3GOVA 4PZ5A 1Z92B 5DN5A 3TVJA 4A5WB 2KMSA 2MCZA 3RJ3D 2W80A 1H2QP 5FO8C 3OXUD 2ZYCA 3IX0A 2G7IA 3L89M 3OEDC 2YRAA 4AYEA 4B2SA 1RLHA 1H2PP 4N7EA 4MUCA 1MD7A 4CSYA 1PPQA 1CKLA 3CI0J 3FGRA 5HYTB 1GHQB 3M7PA 1C1ZA 1VVCA 2XRBA 3O8EB 5HYUB 3CALA 1U5MA 3ZD1A 2QY0A 2EC3A 4APLA 1OK1A 3WSXA 1H04P 1OK2A 1OJWA 4YNXA 1QUBA 3EJHA 4DJZA 2CG7A 2XRDA 3OP8A 4YIZA 2V8EA 3INBC 5I0QB 1OJYA 3VWOA 5HYPA 3T5OA 1HFHA 2RL0A 2X2ZA 3KXVA 3ZLEA 1ZJKA 4F4OC 3ERBA 3WSYA 2Y8TA 2A55A 1GPZA 2EHFA 2UWNA 2CG6A 2O39C 3MQLA 1HFIA 2ERJA 3R62A 3ZRZA 2LOJA 2RKYA 4ONTD 4BWCA 2XWBF 4AYDA 1QO6A 4MSLA 2JGWA 1SS2A 1OK3A 2IZ4A 3ZLDA
chains in the Genus database with same CATH topology
2I2LA 3F6KA 2X2ZA 3ZLEA 4N7EA 3NJAA 3WSYA 3FGTA 3FGRA 2Y8TA 2Y8RA 4APLA 3WSXA 4BWCA 4MSLA 4PO7A 4YIZA 2Y8SA 3ZLDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WSY A;  3F6K A;  4MSL A;  4PO7 A;  3WSX A;  4N7E A; 
#chains in the Genus database with same CATH topology
 2I2L A;  2XQW C;  3F6K A;  1OJV A;  2RLQ A;  4IGD A;  2JRA A;  1QGB A;  4LOT A;  1E88 A;  4B2R A;  1E5G A;  4JHS A;  4WJG 2;  1G4F A;  1G4G A;  1H03 P;  5DN4 A;  1E8B A;  1TPM A;  2B5I D;  4KKD A;  3KZJ A;  1TPG A;  2WII C;  1LY2 A;  1Q3X A;  1UOT P;  2YBY A;  4LOS A;  1NWV A;  4PO7 A;  2BZM A;  2Y8S A;  4AYI A;  1MD8 A;  2MCY A;  3GXE A;  1GKN A;  1SRZ A;  3NFP I;  2JGX A;  2W81 A;  2KRI A;  3ZD2 A;  4AYM A;  3NJA A;  4J38 B;  2CKU A;  3FGT A;  5JPM G;  1GKG A;  3IU3 I;  4ZH1 D;  4FXG G;  1HCC A;  5HZP B;  3SW0 X;  2IZ3 A;  1O9A A;  1VVD A;  2Y8R A;  4K12 A;  2XWJ I;  1TPN A;  4C16 A;  2RKZ A;  2RLP A;  1FBR A;  1ELV A;  1OK9 A;  3K3T A;  3GOV A;  4PZ5 A;  1Z92 B;  5DN5 A;  3TVJ A;  4A5W B;  2KMS A;  2MCZ A;  3RJ3 D;  2W80 A;  1H2Q P;  5FO8 C;  3OXU D;  2ZYC A;  3IX0 A;  2G7I A;  3L89 M;  3OED C;  2YRA A;  4AYE A;  4B2S A;  1RLH A;  1H2P P;  4N7E A;  4MUC A;  1MD7 A;  4CSY A;  1PPQ A;  1CKL A;  3CI0 J;  3FGR A;  5HYT B;  1GHQ B;  3M7P A;  1C1Z A;  1VVC A;  2XRB A;  3O8E B;  5HYU B;  3CAL A;  1U5M A;  3ZD1 A;  2QY0 A;  2EC3 A;  4APL A;  1OK1 A;  3WSX A;  1H04 P;  1OK2 A;  1OJW A;  4YNX A;  1QUB A;  3EJH A;  4DJZ A;  2CG7 A;  2XRD A;  3OP8 A;  4YIZ A;  2V8E A;  3INB C;  5I0Q B;  1OJY A;  3VWO A;  5HYP A;  3T5O A;  1HFH A;  2RL0 A;  2X2Z A;  3KXV A;  3ZLE A;  1ZJK A;  4F4O C;  3ERB A;  3WSY A;  2Y8T A;  2A55 A;  1GPZ A;  2EHF A;  2UWN A;  2CG6 A;  2O39 C;  3MQL A;  1HFI A;  2ERJ A;  3R62 A;  3ZRZ A;  2LOJ A;  2RKY A;  4ONT D;  4BWC A;  2XWB F;  4AYD A;  1QO6 A;  4MSL A;  2JGW A;  1SS2 A;  1OK3 A;  2IZ4 A;  3ZLD A; 
#chains in the Genus database with same CATH homology
 2I2L A;  3F6K A;  2X2Z A;  3ZLE A;  4N7E A;  3NJA A;  3WSY A;  3FGT A;  3FGR A;  2Y8T A;  2Y8R A;  4APL A;  3WSX A;  4BWC A;  4MSL A;  4PO7 A;  4YIZ A;  2Y8S A;  3ZLD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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